The University of Queensland

Computational design of α‐conotoxins to target specific nicotinic acetylcholine receptor subtypes

Wu, Xiaosa, Hone, Arik J, Huang, Yen-Hua, Clark, Richard J, McIntosh, J Michael, Kaas, Quentin and Craik, David J (2023). Computational design of α‐conotoxins to target specific nicotinic acetylcholine receptor subtypes. Chemistry – A European Journal, 30 (7) e202302909, e202302909. doi: 10.1002/chem.202302909

Mutations within the selectivity filter reveal that Kv1 channels have distinct propensities to slow inactivate

Wu, Xiaosa, Gupta, Kanchan and Swartz, Kenton J. (2022). Mutations within the selectivity filter reveal that Kv1 channels have distinct propensities to slow inactivate. Journal of General Physiology, 154 (11). doi: 10.1085/jgp.202213222

ɑO-Conotoxin GeXIVA isomers modulate N-type calcium (CaV2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABAB receptor activation

Yousuf, Arsalan, Wu, Xiaosa, Bony, Anuja R., Sadeghi, Mahsa, Huang, Yen-Hua, Craik, David J. and Adams, David J. (2022). ɑO-Conotoxin GeXIVA isomers modulate N-type calcium (CaV2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABAB receptor activation. Journal of Neurochemistry, 160 (2), 154-171. doi: 10.1111/jnc.15535

Interactions of globular and ribbon [γ4E]GID with α4β2 neuronal nicotinic acetylcholine receptor

Wu, Xiaosa, Craik, David J. and Kaas, Quentin (2021). Interactions of globular and ribbon [γ4E]GID with α4β2 neuronal nicotinic acetylcholine receptor. Marine Drugs, 19 (9) 482. doi: 10.3390/md19090482

Periplasmic expression of 4/7 alpha-conotoxin TxIA analogs in E. coli favors ribbon isomer formation suggestion of a binding mode at the α7 nAChR

El Hamdaoui, Yamina, Wu, Xiaosa, Clark, Richard J., Giribaldi, Julien, Anangi, Raveendra, Craik, David J., King, Glenn F., Dutertre, Sebastien, Kaas, Quentin, Herzig, Volker and Nicke, Annette (2019). Periplasmic expression of 4/7 alpha-conotoxin TxIA analogs in E. coli favors ribbon isomer formation suggestion of a binding mode at the α7 nAChR. Frontiers in Pharmacology, 10 (MAY) 577, 577. doi: 10.3389/fphar.2019.00577

Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB

Wu, Xiaosa, Tae, Han-Shen, Huang, Yen-Hua, Adams, David J., Craik, David J. and Kaas, Quentin (2018). Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB. Biochemical Pharmacology, 155, 288-297. doi: 10.1016/j.bcp.2018.07.007

Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer

Wu, Xiaosa, Huang, Yen-Hua, Kaas, Quentin, Harvey, Peta J., Wang, Conan K., Tae, Han-Shen, Adams, David J. and Craik, David J. (2017). Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer. Journal of Biological Chemistry, 292 (41), 17101-17112. doi: 10.1074/jbc.M117.808386

Cyclisation of disulfide-rich conotoxins in drug design applications

Wu, Xiaosa, Huang, Yen-Hua, Kaas, Quentin and Craik, David J. (2016). Cyclisation of disulfide-rich conotoxins in drug design applications. European Journal of Organic Chemistry, 2016 (21), 3462-3472. doi: 10.1002/ejoc.201600402

Front Cover: Cyclisation of Disulfide-Rich Conotoxins in Drug Design Applications (Eur. J. Org. Chem. 21/2016)

Wu, Xiaosa, Huang, Yen-Hua, Kaas, Quentin and Craik, David J. (2016). Front Cover: Cyclisation of Disulfide-Rich Conotoxins in Drug Design Applications (Eur. J. Org. Chem. 21/2016). European Journal of Organic Chemistry, 2016 (21), 3457-3457. doi: 10.1002/ejoc.201670211

Influence of disulfide connectivity on structure and bioactivity of alpha-conotoxin TxIA

Wu, Yong, Wu, Xiaosa, Yu, Jinpeng, Zhu, Xiaopeng, Zhangsun, Dongting and Luo, Sulan (2014). Influence of disulfide connectivity on structure and bioactivity of alpha-conotoxin TxIA. Molecules, 19 (1), 966-979. doi: 10.3390/molecules19010966

Optimal cleavage and oxidative folding of alpha-conotoxin TxIB as a therapeutic candidate pPeptide

Wu, Xiaosa, Wu, Yong, Zhu, Furong, Yang, Qiuyuan, Wu, Qianqian, Zhangsun, Dongting and Luo, Sulan (2013). Optimal cleavage and oxidative folding of alpha-conotoxin TxIB as a therapeutic candidate pPeptide. Marine Drugs, 11 (9), 3537-3553. doi: 10.3390/md11093537

Expression and secretion of functional recombinant mu O-conotoxin MrVIB-His-tag in Escherichia coli

Gao, Bingmiao, Zhangsun, Dongting, Hu, Yuanyan, Wu, Yong, Sheng, Lizi, Fang, Licong, Wu, Xiaosa, Yu, Jinpeng and Luo, Sulan (2013). Expression and secretion of functional recombinant mu O-conotoxin MrVIB-His-tag in Escherichia coli. Toxicon, 72, 81-89. doi: 10.1016/j.toxicon.2013.06.012

Engineering the ribbon isomer of α-conotoxins in the drug design application

Wu, Xiaosa (2019). Engineering the ribbon isomer of α-conotoxins in the drug design application. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi: 10.14264/uql.2019.537