The University of Queensland

Whole transcriptome profiling of placental pathobiology in SARS‐CoV‐2 pregnancies identifies placental dysfunction signatures

Stylianou, Nataly, Sebina, Ismail, Matigian, Nicholas, Monkman, James, Doehler, Hadeel, Röhl, Joan, Allenby, Mark, Nam, Andy, Pan, Liuliu, Rockstroh, Anja, Sadeghirad, Habib, Chung, Kimberly, Sobanski, Thais, O'Byrne, Ken, Almeida, Ana Clara Simoes Florido, Rebutini, Patricia Zadorosnei, Machado‐Souza, Cleber, Stonoga, Emanuele Therezinha Schueda, Warkiani, Majid E, Salomon, Carlos, Short, Kirsty, McClements, Lana, de Noronha, Lucia, Huang, Ruby, Belz, Gabrielle T, Souza‐Fonseca‐Guimaraes, Fernando, Clifton, Vicki and Kulasinghe, Arutha (2024). Whole transcriptome profiling of placental pathobiology in SARS‐CoV‐2 pregnancies identifies placental dysfunction signatures. Clinical & Translational Immunology, 13 (2) e1488, e1488. doi: 10.1002/cti2.1488

Research funding for newborn health and stillbirths, 2011–20: a systematic analysis of levels and trends

Agravat, Priyesh, Loucaides, Eva M, Kumar, Meghan Bruce, Howells, Anna, García, Alexandra Molina, Sebina, Ismail, Balanza, Núria, Fitchett, Elizabeth J A and Lawn, Joy E (2023). Research funding for newborn health and stillbirths, 2011–20: a systematic analysis of levels and trends. The Lancet Global Health, 11 (11), e1794-e1804. doi: 10.1016/s2214-109x(23)00379-0

IL-33-induced neutrophilic inflammation and NETosis underlie rhinovirus-triggered exacerbations of asthma

Curren, Bodie, Ahmed, Tufael, Howard, Daniel R, Ashik Ullah, Md., Sebina, Ismail, Rashid, Ridwan B, Al Amin Sikder, Md., Namubiru, Patricia, Bissell, Alec, Ngo, Sylvia, Jackson, David J, Toussaint, Marie, Edwards, Michael R., Johnston, Sebastian L, McSorley, Henry J. and Phipps, Simon (2023). IL-33-induced neutrophilic inflammation and NETosis underlie rhinovirus-triggered exacerbations of asthma. Mucosal Immunology, 16 (5), 671-684. doi: 10.1016/j.mucimm.2023.07.002

Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection

Sikder, Md. Al Amin, Rashid, Ridwan B., Ahmed, Tufael, Sebina, Ismail, Howard, Daniel R., Ullah, Md. Ashik, Rahman, Muhammed Mahfuzur, Lynch, Jason P., Curren, Bodie, Werder, Rhiannon B., Simpson, Jennifer, Bissell, Alec, Morrison, Mark, Walpole, Carina, Radford, Kristen J., Kumar, Vinod, Woodruff, Trent M., Ying, Tan Hui, Ali, Ayesha, Kaiko, Gerard E., Upham, John W., Hoelzle, Robert D., Cuív, Páraic Ó., Holt, Patrick G., Dennis, Paul G. and Phipps, Simon (2023). Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection. Immunity, 56 (5), 1098-1114.e10. doi: 10.1016/j.immuni.2023.03.002

IFN-λ diminishes the severity of viral bronchiolitis in neonatal mice by limiting NADPH oxidase–induced PAD4-independent NETosis

Sebina, Ismail, Rashid, Ridwan B., Sikder, Md. Al Amin, Rahman, Muhammed Mahfuzur, Ahmed, Tufael, Radford-Smith, Daniel E., Kotenko, Sergei V., Hill, Geoffrey R., Bald, Tobias and Phipps, Simon (2022). IFN-λ diminishes the severity of viral bronchiolitis in neonatal mice by limiting NADPH oxidase–induced PAD4-independent NETosis. The Journal of Immunology, 208 (12), 2806-2816. doi: 10.4049/jimmunol.2100876

Synergism and antagonism of bacterial-viral coinfection in the upper respiratory tract

Manna, Sam, McAuley, Julie, Jacobson, Jonathan, Nguyen, Cattram D., Ullah, Md Ashik, Sebina, Ismail, Williamson, Victoria, Mulholland, E. Kim, Wijburg, Odilia, Phipps, Simon and Satzke, Catherine (2022). Synergism and antagonism of bacterial-viral coinfection in the upper respiratory tract. mSphere, 7 (1) e00984-21. doi: 10.1128/msphere.00984-21

Targeting the P2Y13 receptor suppresses IL-33 and HMGB1 release and ameliorates experimental asthma

Werder, Rhiannon B., Ullah, Md Ashik, Rahman, Muhammed Mahfuzur, Simpson, Jennifer, Lynch, Jason P., Collinson, Natasha, Rittchen, Sonja, Rashid, Ridwan B., Sikder, Md Al Amin, Handoko, Herlina Y., Curren, Bodie F., Sebina, Ismail, Hartel, Gunter, Bissell, Alec, Ngo, Sylvia, Yarlagadda, Tejasri, Hasnain, Sumaira Z., Lu, Wenying, Sohal, Sukhwinder S., Martin, Megan, Bowler, Simon, Burr, Lucy D., Martinez, Laurent O., Robaye, Bernard, Spann, Kirsten, Ferreira, Manuel A. R. and Phipps, Simon (2022). Targeting the P2Y13 receptor suppresses IL-33 and HMGB1 release and ameliorates experimental asthma. American Journal of Respiratory and Critical Care Medicine, 205 (3), 300-312. doi: 10.1164/rccm.202009-3686oc

Mycobacterium tuberculosis infection is associated with increased B cell responses to unrelated pathogens

Kimuda, Simon G., Andia-Biraro, Irene, Sebina, Ismail, Egesa, Moses, Nalwoga, Angela, Smith, Steven G., Bagaya, Bernard S., Levin, Jonathan, Elliott, Alison M., Raynes, John G. and Cose, Stephen (2020). Mycobacterium tuberculosis infection is associated with increased B cell responses to unrelated pathogens. Scientific Reports, 10 (1) 14324, 14324. doi: 10.1038/s41598-020-71044-4

The contribution of neutrophils to the pathogenesis of RSV bronchiolitis

Sebina, Ismail and Phipps, Simon (2020). The contribution of neutrophils to the pathogenesis of RSV bronchiolitis. Viruses, 12 (8) 808, 808. doi: 10.3390/v12080808

Long-lived regulatory T cells generated during severe bronchiolitis in infancy influence later progression to asthma

Lynch, Jason P., Werder, Rhiannon B., Curren, Bodie F., Sikder, Md. Al Amin, Ullah, Ashik, Sebina, Ismail, Rashid, Ridwan B., Zhang, Vivian, Upham, John W., Hill, Geoff R., Steptoe, Raymond J. and Phipps, Simon (2020). Long-lived regulatory T cells generated during severe bronchiolitis in infancy influence later progression to asthma. Mucosal Immunology, 13 (4), 652-664. doi: 10.1038/s41385-020-0268-8

PAG1 limits allergen-induced type 2 inflammation in the murine lung

Ullah, Md Ashik, Vicente, Cristina T., Collinson, Natasha, Curren, Bodie, Sikder, Md Al Amin, Sebina, Ismail, Simpson, Jennifer, Varelias, Antiopi, Lindquist, Jonathan A., Ferreira, Manuel A. R. and Phipps, Simon (2020). PAG1 limits allergen-induced type 2 inflammation in the murine lung. Allergy, 75 (2) all.13991, 336-345. doi: 10.1111/all.13991

Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells

Akter, Jasmin, Khoury, David S., Aogo, Rosemary, Lansink, Lianne I. M., SheelaNair, Arya, Thomas, Bryce S., Laohamonthonkul, Pawat, Pernold, Clara P. S., Dixon, Matthew W. A., Soon, Megan S. F., Fogg, Lily G., Engel, Jessica A., Elliott, Trish, Sebina, Ismail, James, Kylie R., Cromer, Deborah, Davenport, Miles P. and Haque, Ashraful (2019). Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells. PLoS Pathogens, 15 (2) e1007599, e1007599. doi: 10.1371/journal.ppat.1007599

Determinants of gammaherpesvirus shedding in saliva among Ugandan children and their mothers

Newton, Robert, Labo, Nazzarena, Wakeham, Katie, Marshall, Vickie, Roshan, Romin, Nalwoga, Angela, Sebina, Ismail, Muhangi, Lawrence, Webb, Emily L., Miley, Wendell, Rochford, Rosemary, Elliott, Alison M. and Whitby, Denise (2018). Determinants of gammaherpesvirus shedding in saliva among Ugandan children and their mothers. Journal of Infectious Diseases, 218 (6), 892-900. doi: 10.1093/infdis/jiy262

Effects of type I interferons in malaria

Sebina, Ismail and Haque, Ashraful (2018). Effects of type I interferons in malaria. Immunology, 155 (2), 176-185. doi: 10.1111/imm.12971

Humoral immune responses to infection: common mechanisms and unique strategies to combat pathogen immune evasion tactics

Sebina, Ismail and Pepper, Marion (2018). Humoral immune responses to infection: common mechanisms and unique strategies to combat pathogen immune evasion tactics. Current Opinion in Immunology, 51, 46-54. doi: 10.1016/j.coi.2018.02.001

IFN regulatory factor 3 balances Th1 and T follicular helper immunity during nonlethal blood-stage Plasmodium infection

James, Kylie R., Soon, Megan S. F., Sebina, Ismail, Fernandez-Ruiz, Daniel, Davey, Gayle, Liligeto, Urijah N., Nair, Arya Sheela, Fogg, Lily G., Edwards, Chelsea L., Best, Shannon E., Lansink, Lianne I. M., Schroder, Kate, Wilson, Jane A. C., Austin, Rebecca, Suhrbier, Andreas, Lane, Steven W., Hill, Geoffrey R., Engwerda, Christian R., Heath, William R. and Haque, Ashraful (2018). IFN regulatory factor 3 balances Th1 and T follicular helper immunity during nonlethal blood-stage Plasmodium infection. Journal of Immunology, 200 (4), 1443-1456. doi: 10.4049/jimmunol.1700782

Characterising the effect of antimalarial drugs on the maturation and clearance of murine blood-stage Plasmodium parasites in vivo

Khoury, David S., Cromer, Deborah, Elliott, Trish, Soon, Megan S. F., Thomas, Bryce S., James, Kylie R., Best, Shannon E., Aogo, Rosemary A., Engel, Jessica A., Gartlan, Kate H., Akter, Jasmin, Sebina, Ismail, Haque, Ashraful and Davenport, Miles P. (2017). Characterising the effect of antimalarial drugs on the maturation and clearance of murine blood-stage Plasmodium parasites in vivo. International Journal for Parasitology, 47 (14), 913-922. doi: 10.1016/j.ijpara.2017.05.009

IL-6 promotes CD4(+) T-cell and B-cell activation during Plasmodium infection

Sebina, I., Fogg, L. G., James, K. R., Soon, M. S. F., Akter, J., Thomas, B. S., Hill, G. R., Engwerda, C. R. and Haque, A. (2017). IL-6 promotes CD4(+) T-cell and B-cell activation during Plasmodium infection. Parasite Immunology, 39 (10) e12455, e12455. doi: 10.1111/pim.12455

Host-mediated impairment of parasite maturation during blood-stage Plasmodium infection

Khoury, David S., Cromer, Deborah, Akter, Jasmin, Sebina, Ismail, Elliott, Trish, Thomas, Bryce S., Soon, Megan S. F., James, Kylie R., Best, Shannon E., Haque, Ashraful and Davenport, Miles P. (2017). Host-mediated impairment of parasite maturation during blood-stage Plasmodium infection. Proceedings of the National Academy of Sciences of the United States of America, 114 (29), 7701-7706. doi: 10.1073/pnas.1618939114

Single-cell RNA-seq and computational analysis using temporal mixture modeling resolves TH1/TFHfate bifurcation in malaria

Lönnberg, Tapio, Svensson, Valentine, James, Kylie R., Fernandez-Ruiz, Daniel, Sebina, Ismail, Montandon, Ruddy, Soon, Megan S. F., Fogg, Lily G., Nair, Arya Sheela, Liligeto, Urijah N., Stubbington, Michael J. T., Ly, Lam-Ha, Bagger, Frederik Otzen, Zwiessele, Max, Lawrence, Neil D., Souza-Fonseca-Guimaraes, Fernando, Bunn, Patrick T., Engwerda, Christian R., Heath, William R., Billker, Oliver, Stegle, Oliver, Haque, Ashraful and Teichmann, Sarah A. (2017). Single-cell RNA-seq and computational analysis using temporal mixture modeling resolves TH1/TFHfate bifurcation in malaria. Science Immunology, 2 (9) eaal2192, eaal2192. doi: 10.1126/sciimmunol.aal2192

IFNAR1-signalling obstructs ICOS-mediated humoral immunity during non-lethal blood-stage Plasmodium infection

Sebina, Ismail, James, Kylie R., Soon, Megan S. F., Fogg, Lily G., Best, Shannon E., Labastida Rivera, Fabian de, Montes de Oca, Marcela, Amante, Fiona H., Thomas, Bryce S., Beattie, Lynette, Souza-Fonseca-Guimaraes, Fernando, Smyth, Mark J., Hertzog, Paul J., Hill, Geoffrey R., Hutloff, Andreas, Engwerda, Christian R. and Haque, Ashraful (2016). IFNAR1-signalling obstructs ICOS-mediated humoral immunity during non-lethal blood-stage Plasmodium infection. PLoS Pathogens, 12 (11) e1005999, e1005999. doi: 10.1371/journal.ppat.1005999

Reduced erythrocyte susceptibility and increased host clearance of young parasites slows Plasmodium growth in a murine model of severe malaria

Khoury, David S., Cromer, Deborah, Best, Shannon E., James, Kylie R., Sebina, Ismail, Haque, Ashraful and Davenport, Miles P. (2015). Reduced erythrocyte susceptibility and increased host clearance of young parasites slows Plasmodium growth in a murine model of severe malaria. Scientific Reports, 5 (9412) 9412. doi: 10.1038/srep09412

Coinfection with blood-stage plasmodium promotes systemic type I interferon production during pneumovirus infection but impairs inflammation and viral control in the lung

Edwards, Chelsea L., Zhang, Vivian, Werder, Rhiannon B., Best, Shannon E., Sebina, Ismail, James, Kylie R., Faleiro, Rebecca J., Rivera, Fabian de Labastida, Amante, Fiona H., Engwerda, Christian R., Phipps, Simon and Haque, Ashraful (2015). Coinfection with blood-stage plasmodium promotes systemic type I interferon production during pneumovirus infection but impairs inflammation and viral control in the lung. Clinical and Vaccine Immunology, 22 (5), 477-483. doi: 10.1128/CVI.00051-15

Spatiotemporal requirements for IRF7 in mediating type I IFN-dependent susceptibility to blood-stage Plasmodium infection

Edwards, Chelsea L., Best, Shannon E., Gun, Sin Yee, Claser, Carla, James, Kylie R., de Oca, Marcela M., Sebina, Ismail, Rivera, Fabian de Labastida, Amante, Fiona H., Hertzog, Paul J., Engwerda, Christian R., Renia, Laurent and Haque, Ashraful (2015). Spatiotemporal requirements for IRF7 in mediating type I IFN-dependent susceptibility to blood-stage Plasmodium infection. European Journal of Immunology, 45 (1), 130-141. doi: 10.1002/eji.201444824

Circulating B-lymphocytes as potential biomarkers of tuberculosis infection activity

Sebina, Ismail, Biraro, Irene A., Dockrell, Hazel M., Elliott, Alison M. and Cose, Stephen (2014). Circulating B-lymphocytes as potential biomarkers of tuberculosis infection activity. PLoS One, 9 (9) e106796, e106796. doi: 10.1371/journal.pone.0106796

Type I IFN signaling in CD8-DCs impairs Th1-dependent malaria immunity

Haque, Ashraful, Best, Shannon E., De Oca, Marcela Montes, James, Kylie R., Ammerdorffer, Anne, Edwards, Chelsea L., De Labastida Rivera, Fabian, Amante, Fiona H., Bunn, Patrick T., Sheel, Meru, Sebina, Ismail, Koyama, Motoko, Varelias, Antiopi, Hertzog, Paul J., Kalinke, Ulrich, Gun, Sin Yee, Renia, Laurent, Ruedl, Christiane, MacDonald, Kelli P.A., Hill, Geoffrey R. and Engwerda, Christian R. (2014). Type I IFN signaling in CD8-DCs impairs Th1-dependent malaria immunity. Journal of Clinical Investigation, 124 (6), 2483-2496. doi: 10.1172/JCI70698

Long-lived memory B-cell responses following BCG vaccination

Sebina, Ismail, Cliff, Jacqueline M., Smith, Steven G., Nogaro, Sarah, Webb, Emily L., Riley, Eleanor M., Dockrell, Hazel M., Elliott, Alison M., Hafalla, Julius C. R. and Cose, Stephen (2012). Long-lived memory B-cell responses following BCG vaccination. PLoS One, 7 (12), e51381. doi: 10.1371/journal.pone.0051381

Determining Mycobacterium tuberculosis infection among BCG-immunised Ugandan children by T-SPOT.TB and tuberculin skin testing

Nkurunungi, Gyaviira, Lutangira, Jimreeves E., Lule, Swaib A., Akurut, Hellen, Kizindo, Robert, Fitchett, Joseph R., Kizito, Dennison, Sebina, Ismail, Muhangi, Lawrence, Webb, Emily L., Cose, Stephen and Elliott, Alison M. (2012). Determining Mycobacterium tuberculosis infection among BCG-immunised Ugandan children by T-SPOT.TB and tuberculin skin testing. PLoS One, 7 (10) e47340, e47340. doi: 10.1371/journal.pone.0047340

Parasite infection is associated with Kaposi's sarcoma associated herpesvirus (KSHV) in Ugandan women

Wakeham, Katie, Webb, Emily L., Sebina, Ismail, Muhangi, Lawrence, Miley, Wendell, Johnson, W. Thomas, Ndibazza, Juliet, Elliott, Alison M., Whitby, Denise and Newton, Robert (2011). Parasite infection is associated with Kaposi's sarcoma associated herpesvirus (KSHV) in Ugandan women. Infectious Agents and Cancer, 6 (1) 15, 15. doi: 10.1186/1750-9378-6-15

888 Research funding for newborn health and stillbirths: systematic analyses of levels and trends (2011–2020) with implications for impact

Agravat, Priyesh, Loucaides, Eva M, Kumar, Meghan, Howells, Anna, García, Alexandra Molina, Sebina, Ismail, Balanza, Nuria, Fitchett, Elizabeth JA and Lawn, Joy (2023). 888 Research funding for newborn health and stillbirths: systematic analyses of levels and trends (2011–2020) with implications for impact. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health. doi: 10.1136/archdischild-2023-rcpch.497

Risk factors for seropositivity to Kaposi sarcoma-associated herpesvirus among children in Uganda

Wakeham, Katie, Webb, Emily L., Sebina, Ismail, Nalwoga, Angela, Muhangi, Lawrence, Miley, Wendell, Johnston, W. Thomas, Ndibazza, Juliet, Whitby, Denise, Newton, Robert and Elliott, Alison M. (2013). Risk factors for seropositivity to Kaposi sarcoma-associated herpesvirus among children in Uganda. 14th International Workshop on Kaposi's Sarcoma Herpesvirus (KSHV) and Related Agents, Helsinki, Finland, August 2011. Philadelphia, PA, United States: Lippincott Williams & Wilkins. doi: 10.1097/QAI.0b013e31828a7056

Immunological mechanisms controlling blood-stage parasites in mouse models of malaria

Sebina, Ismail (2017). Immunological mechanisms controlling blood-stage parasites in mouse models of malaria. PhD Thesis, School of Medicine, The University of Queensland. doi: 10.14264/uql.2017.482