The University of Queensland

Local activation of focal adhesion kinase orchestrates the positioning of presynaptic scaffold proteins and Ca2+ signalling to control glucose-dependent insulin secretion

Jevon, Dillon, Deng, Kylie, Hallahan, Nicole, Kumar, Krish, Tong, Jason, Gan, Wan Jun, Tran, Clara, Bilek, Marcela and Thorn, Peter (2022). Local activation of focal adhesion kinase orchestrates the positioning of presynaptic scaffold proteins and Ca2+ signalling to control glucose-dependent insulin secretion. eLife, 11 e76262, 1-25. doi: 10.7554/elife.76262

Mechanochemical control of symmetry breaking in the Caenorhabditis elegans zygote

Gan, Wan Jun and Motegi, Fumio (2021). Mechanochemical control of symmetry breaking in the Caenorhabditis elegans zygote. Frontiers in Cell and Developmental Biology, 8 619869, 1-11. doi: 10.3389/fcell.2020.619869

Structural and functional polarisation of human pancreatic beta cells in islets from organ donors with and without type 2 diabetes

Cottle, Louise, Gan, Wan Jun, Gilroy, Ian, Samra, Jaswinder S., Gill, Anthony J., Loudovaris, Thomas, Thomas, Helen E., Hawthorne, Wayne J., Kebede, Melkam A. and Thorn, Peter (2021). Structural and functional polarisation of human pancreatic beta cells in islets from organ donors with and without type 2 diabetes. Diabetologia, 64 (3), 618-629. doi: 10.1007/s00125-020-05345-8

HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling

Loh, Zhixuan, Simpson, Jennifer, Ullah, Ashik, Zhang, Vivian, Gan, Wan J., Lynch, Jason P., Werder, Rhiannon B., Sikder, Al Amin, Lane, Katie, Sim, Choon Boon, Porrello, Enzo, Mazzone, Stuart B., Sly, Peter D., Steptoe, Raymond J., Spann, Kirsten M., Sukkar, Maria B., Upham, John W. and Phipps, Simon (2020). HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling. PLoS Pathogens, 16 (7) e1008651, 1-21. doi: 10.1371/journal.ppat.1008651

ABCA12 regulates insulin secretion from β‐cells

Ursino, Gloria M., Fu, Ying, Cottle, Denny L., Mukhamedova, Nigora, Jones, Lynelle K., Low, Hann, Tham, Ming Shen, Gan, Wan Jun, Mellett, Natalie A., Das, Partha P., Weir, Jacquelyn M., Ditiatkovski, Michael, Fynch, Stacey, Thorn, Peter, Thomas, Helen E., Meikle, Peter J., Parkington, Helena C., Smyth, Ian M. and Sviridov, Dmitri (2020). ABCA12 regulates insulin secretion from β‐cells. EMBO reports, 21 (3), 1-19. doi: 10.15252/embr.201948692

Local integrin activation in pancreatic β cells targets insulin secretion to the vasculature

Gan, Wan Jun, Do, Oanh Hoang, Cottle, Louise, Ma, Wei, Kosobrodova, Elena, Cooper-White, Justin, Bilek, Marcela and Thorn, Peter (2018). Local integrin activation in pancreatic β cells targets insulin secretion to the vasculature. Cell Reports, 24 (11), 2819-2826.e3. doi: 10.1016/j.celrep.2018.08.035

Improved multiprotein microcontact printing on plasma immersion ion implanted polystyrene

Kosobrodova, E., Gan, W. J., Kondyurin, A., Thorn, P. and Bilek, M M M (2018). Improved multiprotein microcontact printing on plasma immersion ion implanted polystyrene. ACS Applied Materials and Interfaces, 10 (1), 227-237. doi: 10.1021/acsami.7b15545

RAGE deficiency predisposes mice to virus-induced paucigranulocytic asthma

Arikkatt, Jaisy, Ullah, Md Ashik, Short, Kirsty Renfree, Zhang, Vivian, Gan, Wan Jun, Loh, Zhixuan, Werder, Rhiannon B., Simpson, Jennifer, Sly, Peter D., Mazzone, Stuart B., Spann, Kirsten M., Ferreira, Manuel A R., Upham, John W., Sukkar, Maria B. and Phipps, Simon (2017). RAGE deficiency predisposes mice to virus-induced paucigranulocytic asthma. eLife, 6 e21199. doi: 10.7554/eLife.21199

Cell polarity defines three distinct domains in pancreatic beta cells

Gan, Wan J., Zavortink, Michael, Ludick, Christine, Templin, Rachel, Webb, Robyn, Webb, Richard, Ma, Wei, Poronnik, Philip, Parton, Robert G., Gaisano, Herbert Y., Shewan, Annette M. and Thorn, Peter (2016). Cell polarity defines three distinct domains in pancreatic beta cells. Journal of Cell Science, 130 (1), 1-9. doi: 10.1242/jcs.185116

Insulin secretion from beta cells in intact mouse islets is targeted towards the vasculature

Low, Jiun T., Zavortink, Michael, Mitchell, Justin M., Gan, Wan J., Do, Oanh Hoang, Schwiening, Christof J., Gaisano, Herbert Y. and Thorn, Peter (2014). Insulin secretion from beta cells in intact mouse islets is targeted towards the vasculature. Diabetologia, 57 (8), 1655-1663. doi: 10.1007/s00125-014-3252-6

Receptor for advanced glycation end products and its ligand high-mobility group box-1 mediate allergic airway sensitization and airway inflammation

Ullah, Md Ashik, Loh, Zhixuan, Gan, Wan Jun, Zhang, Vivian, Yang, Huan, Li, Jian Hua, Yamamoto, Yasuhiko, Schmidt, Ann Marie, Armour, Carol L., Hughes, J. Margaret, Phipps, Simon and Sukkar, Maria B. (2014). Receptor for advanced glycation end products and its ligand high-mobility group box-1 mediate allergic airway sensitization and airway inflammation. Journal of Allergy and Clinical Immunology, 134 (2), 440-450.e3. doi: 10.1016/j.jaci.2013.12.1035

RAGE: a new frontier in chronic airways disease

Sukkar, Maria B., Ullah, Md Ashik, Gan, Wan Jun, Wark, Peter A.B., Chung, Kian Fan, Hughes, Margaret J., Armour, Carol L. and Phipps, Simon (2012). RAGE: a new frontier in chronic airways disease. British Journal of Pharmacology, 167 (6), 1161-1176. doi: 10.1111/j.1476-5381.2012.01984.x

Hmgb1-Rage Axis Mediates House Dust Mite Induced Allergic Sensitization and Airway Inflammation

Ullah, M. A., Loh, Z., Gan, W. J., Zhang, V., Lynch, J., Eacharath, J., Hughes, J. M., Armour, C. L., Phipps, S. and Sukkar, M. B. (2013). Hmgb1-Rage Axis Mediates House Dust Mite Induced Allergic Sensitization and Airway Inflammation. 2013 Annual Scientific Meetings of The Thoracic Society of Australia and New Zealand and the Australian and New Zealand Society of Respiratory Science, Darwin, NT Australia, 22 - 27 March 2013. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.12045

The activation of the receptor for advanced glycation end products (RAGE) contributes to the induction of Hdm-specific T(h)2 responses

Ullah, MD Ashik, Gan, Wan J., Loh, Zhixuan, Zhang, Vivian, Hughes, J. Margaret, Armour, Carol L., Phipps, Simon and Sukkar, Maria B. (2012). The activation of the receptor for advanced glycation end products (RAGE) contributes to the induction of Hdm-specific T(h)2 responses. Thoracic Society of Australia & New Zealand and the Australian & New Zealand Society of Respiratory Science 2012 Annual Scientific Meetings, Canberra, ACT, Australia, 30 March - 4 April 2012. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1843.2012.02142.x