The University of Queensland

Animal models used for investigating pathophysiology of preeclampsia and identifying therapeutic targets

George, Eric M., Bakrania, Bhavisha A., Granger, Joey P. and Conrad, Kirk P. (2022). Animal models used for investigating pathophysiology of preeclampsia and identifying therapeutic targets. Chesley’s hypertensive disorders in pregnancy. (pp. 435-447) Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-12-818417-2.00015-4

Editorial: Adverse outcomes of preeclampsia: from mother to baby, pregnancy to postpartum

Bakrania, Bhavisha A., Spradley, Frank T. and McClements, Lana (2024). Editorial: Adverse outcomes of preeclampsia: from mother to baby, pregnancy to postpartum. Frontiers in Physiology, 15. doi: 10.3389/fphys.2024.1394120

Expression of TRPM6 and TRPM7 in the preterm piglet heart

Forbes, Elizabeth M., Bakrania, Bhavisha A., Steane, Sarah E., Moritz, Karen M., Lingwood, Barbara E. and Eiby, Yvonne A. (2022). Expression of TRPM6 and TRPM7 in the preterm piglet heart. Frontiers in Pediatrics, 10 891722, 1-11. doi: 10.3389/fped.2022.891722

Sustained elevated circulating activin a impairs global longitudinal strain in pregnant rats: a potential mechanism for preeclampsia-related cardiac dysfunction

Bakrania, Bhavisha A., Palei, Ana C., Bhattarai, Umesh, Chen, Yingjie, Granger, Joey P. and Shahul, Sajid (2022). Sustained elevated circulating activin a impairs global longitudinal strain in pregnant rats: a potential mechanism for preeclampsia-related cardiac dysfunction. Cells, 11 (4) 742, 742. doi: 10.3390/cells11040742

Soluble guanylate cyclase stimulation in late gestation does not mitigate asymmetric IUGR or cardiovascular risk induced by placental ischemia in the rat

Coats, Laura E., Bakrania, Bhavisha A., Bamrick-Fernandez, Daniel R., Ariatti, Allison M., Rawls, Adam Z., Ojeda, Norma B. and Alexander, Barbara T. (2021). Soluble guanylate cyclase stimulation in late gestation does not mitigate asymmetric IUGR or cardiovascular risk induced by placental ischemia in the rat. American Journal of Physiology: Heart and Circulatory Physiology, 320 (5) ajpheart.00033.2021, H1923-H1934. doi: 10.1152/ajpheart.00033.2021

Animal models of preeclampsia: investigating pathophysiology and therapeutic targets

Bakrania, Bhavisha A., George, Eric M. and Granger, Joey P. (2021). Animal models of preeclampsia: investigating pathophysiology and therapeutic targets. American Journal of Obstetrics and Gynecology, 226 (2), S973-S987. doi: 10.1016/j.ajog.2020.10.025

Luteolin-induced vasorelaxation in uterine arteries from normal pregnant rats

Yang, Weiwei, Li, Qinghua, Duncan, Jeremy W., Bakrania, Bhavisha A., Bradshaw, Jessica L., Granger, Joey P., Rana, Sarosh and Spradley, Frank T. (2021). Luteolin-induced vasorelaxation in uterine arteries from normal pregnant rats. Pregnancy Hypertension, 23, 11-17. doi: 10.1016/j.preghy.2020.10.008

Long-term postpartum cardiac function and its association with preeclampsia

deMartelly, Victoria A, Dreixler, John, Tung, Avery, Mueller, Ariel, Heimberger, Sarah, Fazal, Abid A., Naseem, Heba, Lang, Roberto, Kruse, Eric, Yamat, Megan, Granger, Joey P., Bakrania, Bhavisha A., Rodriguez-Kovacs, Javier, Rana, Sarosh and Shahul, Sajid (2021). Long-term postpartum cardiac function and its association with preeclampsia. Journal of the American Heart Association, 10 (5) e018526, 1-9. doi: 10.1161/jaha.120.018526

Stimulation of soluble guanylate cyclase diminishes intrauterine growth restriction in a rat model of placental ischemia

Coats, Laura E., Bamrick-Fernandez, Daniel R., Ariatti, Allison M., Bakrania, Bhavisha A., Rawls, Adam Z., Ojeda, Norma B. and Alexander, Barbara T. (2021). Stimulation of soluble guanylate cyclase diminishes intrauterine growth restriction in a rat model of placental ischemia. AJP: Regulatory, Integrative and Comparative Physiology, 320 (2), R149-R161. doi: 10.1152/ajpregu.00234.2020

Preeclampsia: Linking Placental Ischemia with Maternal Endothelial and Vascular Dysfunction

Bakrania, Bhavisha A., Spradley, Frank T., Drummond, Heather A., LaMarca, Babbette, Ryan, Michael J. and Granger, Joey P. (2020). Preeclampsia: Linking Placental Ischemia with Maternal Endothelial and Vascular Dysfunction. Comprehensive Physiology, 11 (1), 1315-1349. doi: 10.1002/cphy.c200008

Antepartum aspirin administration reduces activin A and cardiac global longitudinal strain in preeclamptic women

Naseem, Heba, Dreixler, John, Mueller, Ariel, Tung, Avery, Dhir, Rohin, Chibber, Rachna, Fazal, Abid, Granger, Joey P., Bakrania, Bhavisha A., deMartelly, Victoria, Rana, Sarosh and Shahul, Sajid (2020). Antepartum aspirin administration reduces activin A and cardiac global longitudinal strain in preeclamptic women. Journal of the American Heart Association, 9 (12) e015997. doi: 10.1161/jaha.119.015997

The Reduced Uterine Perfusion Pressure (RUPP) rat model of preeclampsia exhibits impaired systolic function and global longitudinal strain during pregnancy

Bakrania, Bhavisha A., Hall, Michael E., Shahul, Sajid and Granger, Joey P. (2019). The Reduced Uterine Perfusion Pressure (RUPP) rat model of preeclampsia exhibits impaired systolic function and global longitudinal strain during pregnancy. Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health, 18, 169-172. doi: 10.1016/j.preghy.2019.10.001

Prenatal Sildenafil Therapy Improves Cardiovascular Function in Fetal Growth Restricted Offspring of Dahl Salt-Sensitive Rats

Terstappen, Fieke, Spradley, Frank T., Bakrania, Bhavisha A., Clarke, Sinead M., Joles, Jaap A., Paauw, Nina D., Garrett, Michael R., Lely, A. Titia and Sasser, Jennifer M. (2019). Prenatal Sildenafil Therapy Improves Cardiovascular Function in Fetal Growth Restricted Offspring of Dahl Salt-Sensitive Rats. Hypertension, 73 (5), 1120-1127. doi: 10.1161/hypertensionaha.118.12454

The Endothelin System: A Critical Player in the Pathophysiology of Preeclampsia

Granger, Joey P., Spradley, Frank T. and Bakrania, Bhavisha A. (2018). The Endothelin System: A Critical Player in the Pathophysiology of Preeclampsia. Current Hypertension Reports, 20 (4) 32. doi: 10.1007/s11906-018-0828-4

Bilirubin acts as a multi-potent guardian of cardiovascular integrity: more than just a radical idea

Bulmer, Andrew Cameron, Bakrania, Bhavisha A., Du Toit, Eugene Francois, Boon, Ai-Ching, Clark, Paul J., Powell, Lawrie W., Wagner, Karl-Heinz and Headrick, John P. (2018). Bilirubin acts as a multi-potent guardian of cardiovascular integrity: more than just a radical idea. American Journal of Physiology. Heart and Circulatory Physiology , 315 (3) ajpheart.00417.2017, H429-H447. doi: 10.1152/ajpheart.00417.2017

Heme oxygenase-1 is a potent inhibitor of placental ischemia-mediated endothelin-1 production in cultured human glomerular endothelial cells

Bakrania, Bhavisha A., Spradley, Frank T., Satchell, Simon C., Stec, David E., Rimoldi, John M., Gadepalli, Rama S. V. and Granger, Joey P. (2018). Heme oxygenase-1 is a potent inhibitor of placental ischemia-mediated endothelin-1 production in cultured human glomerular endothelial cells. American Journal of Physiology: Regulatory Integrative and Comparative Physiology, 314 (3), R427-R432. doi: 10.1152/ajpregu.00370.2017

Chronically elevated bilirubin protects from cardiac reperfusion injury in the male Gunn rat

Bakrania, B., Du Toit, E. F., Ashton, K. J., Wagner, K-H., Headrick, J. P. and Bulmer, A. C. (2017). Chronically elevated bilirubin protects from cardiac reperfusion injury in the male Gunn rat. Acta Physiologica, 220 (4), 461-470. doi: 10.1111/apha.12858

Exposure to placental ischemia impairs postpartum maternal renal and cardiac function in rats

Paauw, Nina D., Joles, Jaap A., Spradley, Frank T., Bakrania, Bhavisha, Zsengeller, Zsuzsanna K., Franx, Arie, Verhaar, Marianne C., Granger, Joey P. and Lely, A. Titia (2017). Exposure to placental ischemia impairs postpartum maternal renal and cardiac function in rats. American Journal of Physiology: Regulatory Integrative and Comparative Physiology, 312 (5), R664-R670. doi: 10.1152/ajpregu.00510.2016

The Endothelin Type A Receptor as a Potential Therapeutic Target in Preeclampsia

Bakrania, Bhavisha, Duncan, Jeremy, Warrington, Junie P. and Granger, Joey P. (2017). The Endothelin Type A Receptor as a Potential Therapeutic Target in Preeclampsia. International Journal of Molecular Sciences, 18 (3) 522, 522. doi: 10.3390/ijms18030522

Methods for the Determination of Rates of Glucose and Fatty Acid Oxidation in the Isolated Working Rat Heart

Bakrania, Bhavisha, Granger, Joey P. and Harmancey, Romain (2016). Methods for the Determination of Rates of Glucose and Fatty Acid Oxidation in the Isolated Working Rat Heart. Journal of Visualized Experiments, 2016 (115) e54497. doi: 10.3791/54497

Pre- or post-ischemic bilirubin ditaurate treatment reduces oxidative tissue damage and improves cardiac function

Bakrania, Bhavisha, Du Toit, Eugene F., Wagner, Karl-Heinz, Headrick, John P. and Bulmer, Andrew C. (2016). Pre- or post-ischemic bilirubin ditaurate treatment reduces oxidative tissue damage and improves cardiac function. International Journal of Cardiology, 202, 27-33. doi: 10.1016/j.ijcard.2015.08.192

Hyperbilirubinemia modulates myocardial function, aortic ejection, and ischemic stress resistance in the Gunn rat

Bakrania, Bhavisha, Du Toit, Eugene F., Ashton, Kevin J., Kiessling, Can J., Wagner, Karl-Heinz, Headrick, John P. and Bulmer, Andrew C. (2014). Hyperbilirubinemia modulates myocardial function, aortic ejection, and ischemic stress resistance in the Gunn rat. American Journal of Physiology: Heart and Circulatory Physiology, 307 (8), H1142-H1149. doi: 10.1152/ajpheart.00001.2014

Endogenous tetrapyrroles influence leukocyte responses to lipopolysaccharide in human blood: pre-clinical evidence demonstrating the anti-inflammatory potential of biliverdin

Bisht, Kavita, Tampe, Jens, Shing, Cecilia, Bakrania, Bhavisha, Winearls, James, Fraser, John, Wagner, Karl-Heinz and Bulmer, Andrew C. (2014). Endogenous tetrapyrroles influence leukocyte responses to lipopolysaccharide in human blood: pre-clinical evidence demonstrating the anti-inflammatory potential of biliverdin. Journal of Clinical and Cellular Immunology, 5 (3), 1000218. doi: 10.4172/2155-9899.1000218

Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome

Boon, Ai-Ching, Hawkins, Clare L., Bisht, Kavita, Coombes, Jeff S., Bakrania, Bhavisha, Wagner, Karl-Heinz and Bulmer, Andrew C. (2012). Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome. Free Radical Biology and Medicine, 52 (10), 2120-2127. doi: 10.1016/j.freeradbiomed.2012.03.002

Treatment with the flavonoid, luteolin, attenuates the development of placental ischemia-induced hypertension in pregnant rats

Spradley, Frank, Bakrania, Bhavisha, Eddy, Adrian, Granger, Joey and Rana, Sarosh (2023). Treatment with the flavonoid, luteolin, attenuates the development of placental ischemia-induced hypertension in pregnant rats. American Physiology Summit 2023, Long Beach, CA United States, 20–23 April 2023. Rockville, MD United States: American Physiological Society. doi: 10.1152/physiol.2023.38.s1.5733831

Aspirin Treatment Improves Excess Activin A Associated Cardiac Dysfunction In Pregnancy

Bakrania, Bhavisha A., Palei, Ana, Shahul, Sajid, Hall, Michael and Granger, Joey P. (2022). Aspirin Treatment Improves Excess Activin A Associated Cardiac Dysfunction In Pregnancy. Experimental Biology Meeting EB 2022, Philadelphia, PA United States, 2-5 April 2022. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1096/fasebj.2022.36.S1.R3288

Abstract 013: soluble guanylate cyclase activators improve vascular function and attenuate placental ischemia-induced hypertension

Bakrania, Bhavisha A., Spradley, Frank T., Travis, Adam B., Sandner, Peter and Granger, Joey P. (2018). Abstract 013: soluble guanylate cyclase activators improve vascular function and attenuate placental ischemia-induced hypertension. American Heart Association's Joint Hypertension 2018 Scientific Sessions, Unknown, Unknown. Philadelphia, PA USA: Lippincott Williams & Wilkins. doi: 10.1161/hyp.72.suppl_1.013

Soluble Guanylate Cyclase Activators Improve Vascular Function and Attenuate Placental Ischemia-Induced Hypertension

Bakrania, Bhavisha A., Spradley, Frank T., Travis, Adam B., Sandner, Peter and Granger, Joey P. (2018). Soluble Guanylate Cyclase Activators Improve Vascular Function and Attenuate Placental Ischemia-Induced Hypertension. American Heart Association's Joint Hypertension 2018 Scientific Sessions, Chicago, IL United States, 6-9 September 2018. Philadelphia, PA United States: Lippincott Williams & Wilkins. doi: 10.1161/hyp.72.suppl_1.013

79 Renal and cardiac disturbances 8 weeks after exposure to placental ischemia in rat dams

Paauw, Nina, Joles, Jaap, Spradley, Frank, Bakrania, Bhavisha, Franx, Arie, Verhaar, Marianne, Granger, Joey and Lely, Titia (2016). 79 Renal and cardiac disturbances 8 weeks after exposure to placental ischemia in rat dams. Congress of the International Society for the Study of Hypertension in Pregnancy, Sao Paolo, Brazil, 2016. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.preghy.2016.08.080

Endogenously elevated and exogenously administered bilirubin protects from myocardial ischaemia/reperfusion injury in the rat

Bakrania, B., Du Toit, E., Headrick, J. and Bulmer, A. (2012). Endogenously elevated and exogenously administered bilirubin protects from myocardial ischaemia/reperfusion injury in the rat. Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meeting, Brisbane, QLD Australia, 16-19 August 2012. Chatswood, NSW Australia: Elsevier Australia. doi: 10.1016/j.hlc.2012.05.202

Measuring blood volume in preterm piglets

Morwood, Holly, Bakrania, Bhavisha A., Wright, Ian M. R., Eiby, Yvonne A. and Lingwood, Barbara E. (2022). Measuring blood volume in preterm piglets. The University of Queensland. (Dataset) doi: 10.48610/65b722d

Cardiac TRPM6 and 7 piglets

Forbes, Elizabeth, Bakrania, Bhavisha, Steans, Sarah, Moritz, Karen, Lingwood, Barbara and Eiby, Yvonne (2022). Cardiac TRPM6 and 7 piglets. The University of Queensland. (Dataset) doi: 10.48610/0dac82b