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Associate Professor Rodrigo Suarez

Associate Professor

School of Biomedical Sciences
Faculty of Medicine
r.suarez@uq.edu.au
+61 7 334 66342

Overview

I am a biologist interested in the general question of how changes in developmental processes can lead to evolutionary variation and origin of complex traits (such as neural circuits). I study development and evolution of the brain of mammals. My doctoral thesis studied brain regions involved in olfactory and pheromonal communication in mammals. I discovered several events of parallel co-variation of sensory pathways in distantly related species sharing similar ecological niches, as cases of ontogenetic and phylogenetic plasticity. Currently, I study development and evolution of neocortical circuits by following two main lines of research: one aims to determine how early neuronal activity emerges during development and help shape brain connections, and the other one aims to understand what developmental processes led to evolutionary innovations in the mammalian brain. My research combines molecular development (electroporation, CRISPR), transcriptomics, sensory manipulations, neuroanatomy mapping (MRI, stereotaxic tracer injections, confocal and image analysis), optogenetics, and in vivo calcium imaging (multiphoton and widefield) in rodent pups and marsupial joeys.

Research Interests

  • Comparative vertebrate neuroanatomy
  • Brain development
  • Sensory neuroscience
  • Neuroethology
  • Evolutionary developmental biology
  • Olfaction and pheromones
  • Mammal zoology
  • Neocortical development and function

Qualifications

  • Doctoral Diploma of Biomedical Science, Universidad de Chile

Publications

View all Publications

Grants

View all Grants

Supervision

View all Supervision

Available Projects

  • Role of early neuronal activity on the formation of neocortical circuits

    How does the brain acquire its connectivity pattern during development? What developmental features have been key to the generation of evolutionary diversity of brain architecture in mammals and other vertebrates? By studying comparative development of the cerebral cortex in selected species we aim to gain insights not only on the natural history of the human brain, but also on neurodevelopmental diseases that affect neocortical circuits such as autism and schizophrenia.

    This project aims at elucidating the main roles of early sensory and spontaneous activity in the formation of neocortical layers, areas and circuits. By combining molecular, electrical and developmental manipulations in developing mammalian embryos and pups, this project will study how early events affect the precise formation of cortical features required for normal cognitive development. Highly motivated students with strengths in developmental neurobiology, neurophysiology, animal behaviour, signal analysis and/or computational sciences are encouraged to apply.

  • Multiple projects in comparative and developmental neuroscience

    How does the brain acquire its connectivity pattern during development? What developmental features have been key to the generation of evolutionary diversity of brain architecture in mammals and other vertebrates? By studying comparative development of the cerebral cortex in selected species we aim to gain insights not only on the natural history of the human brain, but also on neurodevelopmental diseases that affect neocortical circuits such as autism and schizophrenia.

    Highly motivated students with a strong scientific formation and original ideas on the evolution and development of the nervous system are particularly encouraged to apply for a RHD student scholarship.

  • Evolution and development of brain wiring genes in marsupials and placentals.

    How does the brain acquire its connectivity pattern during development? What developmental features have been key to the generation of evolutionary diversity of brain architecture in mammals and other vertebrates? By studying comparative development of the cerebral cortex in selected species we aim to gain insights not only on the natural history of the human brain, but also on neurodevelopmental diseases that affect neocortical circuits such as autism and schizophrenia.

    This project aims at elucidating the molecular evolution of genes involved in mammalian brain development. By comparing transcriptomic, cellular and developmental differences between mice and marsupials this project will shed light on the evolution of the largest tract in the brain: the corpus callosum. Highly motivated students with strengths in genetics, bioinformatics, molecular biology, developmental neurobiology, physiology and/or brain anatomy are encouraged to apply.

View all Available Projects

Publications

Book Chapter

Journal Article

Conference Publication

  • Astroglial-mediated remodeling of the interhemispheric midline is exclusive to eutherian mammals and underlies the formation of the corpus callosum

    Gobius, I., Morcom, L., Suarez, R., Bunt, J., Sherr, E. and Richards, L. (2015). Astroglial-mediated remodeling of the interhemispheric midline is exclusive to eutherian mammals and underlies the formation of the corpus callosum. 12th European Meeting on Glial Cell Function in Health and Disease, Bilbao, Spain, 15-18 July 2015. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/glia.22870

  • Astroglial-mediated remodeling of the interhemispheric midline underlies the formation of the corpus callosum in eutherian mammals

    Gobius, I., Morcom, L., Suarez, R., Bunt, J., Sherr, E. H. and Richards, L. J. (2015). Astroglial-mediated remodeling of the interhemispheric midline underlies the formation of the corpus callosum in eutherian mammals. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13188

  • Developmental scenarios for the evolutionary origin of the corpus callosum

    Suarez, R., Paolino, A., Kozulin, P., Morcom, L., Fenlon, L. and Richards, L. (2015). Developmental scenarios for the evolutionary origin of the corpus callosum. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13188

  • The organisation, development and connectivity of two callosal projections arising from the mouse somatosensory cortex

    Fenlon, L., Suarez, R. and Richards, L. (2015). The organisation, development and connectivity of two callosal projections arising from the mouse somatosensory cortex. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13188

Other Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • The evolution and development of axon guidance systems in the cerebral cortex of mammals.

    Doctor Philosophy — Principal Advisor

    Other advisors:

  • Investigating the evolutionary history of early processes of neocortical development

    Doctor Philosophy — Principal Advisor

    Other advisors:

  • The anatomy and functional dynamics of aberrant brain connectivity

    Doctor Philosophy — Associate Advisor

    Other advisors:

  • Timing of gene expression in the evolution of mammalian brain traits

    Doctor Philosophy — Associate Advisor

    Other advisors:

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • Role of early neuronal activity on the formation of neocortical circuits

    How does the brain acquire its connectivity pattern during development? What developmental features have been key to the generation of evolutionary diversity of brain architecture in mammals and other vertebrates? By studying comparative development of the cerebral cortex in selected species we aim to gain insights not only on the natural history of the human brain, but also on neurodevelopmental diseases that affect neocortical circuits such as autism and schizophrenia.

    This project aims at elucidating the main roles of early sensory and spontaneous activity in the formation of neocortical layers, areas and circuits. By combining molecular, electrical and developmental manipulations in developing mammalian embryos and pups, this project will study how early events affect the precise formation of cortical features required for normal cognitive development. Highly motivated students with strengths in developmental neurobiology, neurophysiology, animal behaviour, signal analysis and/or computational sciences are encouraged to apply.

  • Multiple projects in comparative and developmental neuroscience

    How does the brain acquire its connectivity pattern during development? What developmental features have been key to the generation of evolutionary diversity of brain architecture in mammals and other vertebrates? By studying comparative development of the cerebral cortex in selected species we aim to gain insights not only on the natural history of the human brain, but also on neurodevelopmental diseases that affect neocortical circuits such as autism and schizophrenia.

    Highly motivated students with a strong scientific formation and original ideas on the evolution and development of the nervous system are particularly encouraged to apply for a RHD student scholarship.

  • Evolution and development of brain wiring genes in marsupials and placentals.

    How does the brain acquire its connectivity pattern during development? What developmental features have been key to the generation of evolutionary diversity of brain architecture in mammals and other vertebrates? By studying comparative development of the cerebral cortex in selected species we aim to gain insights not only on the natural history of the human brain, but also on neurodevelopmental diseases that affect neocortical circuits such as autism and schizophrenia.

    This project aims at elucidating the molecular evolution of genes involved in mammalian brain development. By comparing transcriptomic, cellular and developmental differences between mice and marsupials this project will shed light on the evolution of the largest tract in the brain: the corpus callosum. Highly motivated students with strengths in genetics, bioinformatics, molecular biology, developmental neurobiology, physiology and/or brain anatomy are encouraged to apply.

This staff member is a UQ Expert for media in the following fields:

trancriptome, connectome, genetics, neuroanatomy, zoology, neural stem cells, neurodevelopmental disease, autism, schizophrenia, in vivo microscopy, magnetic resonance imaging, animal models, optogenetics, gene therapy, brain recovery, Brain evolution, Corpus callosum, cerebral cortex, mammals, smell, olfaction, pheromones, sexual behaviour in animals, brain development, brain wiring, critical period, environmental enrichment, learning, nature versus nurture debate, evolution, evolutionary theory, larmarckism, artificial life, living systems, autopoiesis, experience, brain plasticity, epigenetics, sensory systems, perception, animal behaviour, social behaviour, ethology, neuroethology, teaching, animal ethics, animal research, anatomy, brain anatomy, human brain, philosophy of science, philosophy of biology, neocortex, axon guidance, neuronal programming

They are happy to lend their expertise to your articles or broadcasts and share their research discoveries and insights with the community via media channels.

For additional assistance with story ideas, general advice and information or help with seeking further experts, please email the UQ Media Team or telephone (07) 3365 1120.

Links

ResearcherID: J-1529-2014

ORCID: 0000-0001-5153-5652

Scopus ID: 8426672200

Personal Profile: Link

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