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Connectomes arising: linking structure and function in neocortical wiring. (2024–2027)

Abstract:
The cerebral cortex underpins human cognition, yet precisely how it becomes connected is unknown due to a lack of live developmental assays. We overcome this using prematurely born marsupials, which allow to study cortical development from embryo-like stages with unprecedented resolution. Here, we will study how neural activity arise as first connections are formed, and link functional and structural networks across development in vivo. Experimental manipulations of activity and computational models will unravel the different rules required for precise cortical wiring. Benefits include new methods to study the formation of complex circuits, and refining electrical, molecular and neuroanatomical signatures of early mammalian brain formation.
Grant type:
ARC Discovery Projects
Researchers:
Funded by:
Australian Research Council