The University of Queensland

Advancing Gene Fusion Detection Towards Personalized Cancer Nanodiagnostics

Koo, Kevin M. (2019). Advancing Gene Fusion Detection Towards Personalized Cancer Nanodiagnostics. Cham, Switzerland: Springer. doi: 10.1007/978-3-030-31000-4

Simultaneous BRAFV600E protein and DNA aberration detection in circulating melanoma cells using an integrated multimolecular sensor

Wuethrich, Alain, Dey, Shuvashis, Koo, Kevin M, Sina, Abu A. I. and Trau, Matt (2021). Simultaneous BRAFV600E protein and DNA aberration detection in circulating melanoma cells using an integrated multimolecular sensor. Melanoma. (pp. 265-276) New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-1205-7_20

Interfacial biosensing: direct biosensing of biomolecules at the bare metal interface

Ibn Sina, A. A., Koo, K. M., Ahmed, M., Carrascosa, L. G. and Trau, M. (2018). Interfacial biosensing: direct biosensing of biomolecules at the bare metal interface. Encyclopedia of interfacial chemistry: surface science and electrochemistry. (pp. 269-277) Amsterdam: Elsevier. doi: 10.1016/b978-0-12-409547-2.14188-5

Nanoarchitectonics of point-of-care diagnostics for sweat biomarkers analysis

Lin, Xuan, Vasanth, Arya, Ashok, Aditya, Phan, Hoang-Phuong, Koo, Kevin M., Amin, Mohammed A., Kaneti, Yusuf Valentino, Salomon, Carlos, Hossain, Md Shahriar A., Yamauchi, Yusuke and Masud, Mostafa Kamal (2024). Nanoarchitectonics of point-of-care diagnostics for sweat biomarkers analysis. Nano Materials Science. doi: 10.1016/j.nanoms.2024.01.010

Cancer‐on‐Chip and Integrative Tumor Microenvironment Sensor Technologies for Progressing Precision Radiotherapy

Dey, Shuvashis, Kinoshita, Masaki, Puttick, Simon, Rose, Stephen, Trau, Matt, Roberts, Matthew J. and Koo, Kevin M. (2024). Cancer‐on‐Chip and Integrative Tumor Microenvironment Sensor Technologies for Progressing Precision Radiotherapy. Advanced Sensor Research. doi: 10.1002/adsr.202300193

Design and analytical evaluation of a rapid plasma screening assay for circulating human papillomavirus DNA via thermostable enzyme chemistries

Jaradi, Binny, Das, Tulika and Koo, Kevin M. (2023). Design and analytical evaluation of a rapid plasma screening assay for circulating human papillomavirus DNA via thermostable enzyme chemistries. Analytical Chemistry, 95 (29), 11172-11180. doi: 10.1021/acs.analchem.3c02528

Multifunctional hybrid nanozymes for magnetic enrichment and bioelectrocatalytic sensing of circulating tumor RNA during minimal residual disease monitoring

Koo, Kevin M. (2023). Multifunctional hybrid nanozymes for magnetic enrichment and bioelectrocatalytic sensing of circulating tumor RNA during minimal residual disease monitoring. Catalysts, 13 (1) 178, 1-10. doi: 10.3390/catal13010178

Nanophotonic immunoarray with electrochemically roughened surfaces for handheld detection of secreted PD-L1 to predict immuno-oncology efficacy

Dey, Shuvashis, Koo, Kevin M., Ahmed, Emtiaz and Trau, Matt (2023). Nanophotonic immunoarray with electrochemically roughened surfaces for handheld detection of secreted PD-L1 to predict immuno-oncology efficacy. Lab on a Chip, 23 (15), 3443-3452. doi: 10.1039/d3lc00523b

Exquisitely platinum-sensitive triple-negative breast cancer, time for BRCA methylation testing?

Tan, Tira J., Fink, J. Lynn, Tay, Timothy K., Jaradi, Binny, Stone, Nathan, Waring, Paul, Koo, Kevin M., Tan, Puay Hoon, Tan, Daniel S. and Dent, Rebecca A. (2022). Exquisitely platinum-sensitive triple-negative breast cancer, time for BRCA methylation testing?. JCO Precision Oncology, 6 (6) e2200309, e2200309. doi: 10.1200/po.22.00309

Tetraplex immunophenotyping of cell surface proteomes via synthesized plasmonic nanotags and portable raman spectroscopy

Wang, Jing, Koo, Kevin M. and Trau, Matt (2022). Tetraplex immunophenotyping of cell surface proteomes via synthesized plasmonic nanotags and portable raman spectroscopy. Analytical Chemistry, 94 (43), 14906-14916. doi: 10.1021/acs.analchem.2c02262

Harnessing gene fusion-derived neoantigens for ‘cold’ breast and prostate tumor immunotherapy

Velaga, Ravi, Koo, Kevin M. and Mainwaring, Paul N. (2022). Harnessing gene fusion-derived neoantigens for ‘cold’ breast and prostate tumor immunotherapy. Immunotherapy, 14 (14), 1165-1179. doi: 10.2217/imt-2022-0081

Molecular locker probe enrichment of gene fusion variants from matched patient liquid biopsy specimens for magneto-bioelectrocatalytic nanosensing

Koo, Kevin M. and Trau, Matt (2022). Molecular locker probe enrichment of gene fusion variants from matched patient liquid biopsy specimens for magneto-bioelectrocatalytic nanosensing. Nanoscale, 14 (11), 4225-4233. doi: 10.1039/d1nr07845c

Progressing antimicrobial resistance sensing technologies across human, animal, and environmental health domains

Fitzpatrick, Kira J., Rohlf, Hayden J., Sutherland, Tara D., Koo, Kevin M., Beckett, Sam, Okelo, Walter O., Keyburn, Anthony L., Morgan, Branwen S., Drigo, Barbara, Trau, Matt, Donner, Erica, Djordjevic, Steven P. and De Barro, Paul J. (2021). Progressing antimicrobial resistance sensing technologies across human, animal, and environmental health domains. ACS Sensors, 6 (12) acssensors.1c01973, 4283-4296. doi: 10.1021/acssensors.1c01973

Bioengineered Polymer Nanobeads for Isolation and Electrochemical Detection of Cancer Biomarkers

Soda, Narshone, Gonzaga, Zennia Jean, Chen, Shuxiong, Koo, Kevin M., Nguyen, Nam-Trung, Shiddiky, Muhammad J. A. and Rehm, Bernd H. A. (2021). Bioengineered Polymer Nanobeads for Isolation and Electrochemical Detection of Cancer Biomarkers. ACS applied materials & interfaces, 13 (27) acsami.1c05355, 31418-31430. doi: 10.1021/acsami.1c05355

Separation of distinct exosome subpopulations: isolation and characterization approaches and their associated challenges

Singh, Karishma, Nalabotala, Ruchika, Koo, Kevin M., Bose, Sudeep, Nayak, Ranu and Shiddiky, Muhammad J. A. (2021). Separation of distinct exosome subpopulations: isolation and characterization approaches and their associated challenges. Analyst, 146 (12), 3731-3749. doi: 10.1039/d1an00024a

Magnetic nanomaterial–based electrochemical biosensors for the detection of diverse circulating cancer biomarkers

Koo, Kevin M., Soda, Narshone and Shiddiky, Muhammad J.A. (2021). Magnetic nanomaterial–based electrochemical biosensors for the detection of diverse circulating cancer biomarkers. Current Opinion in Electrochemistry, 25 100645, 100645. doi: 10.1016/j.coelec.2020.100645

Nucleic acid hybridization-based noise suppression for ultraselective multiplexed amplification of mutant variants

Zeng, Yi, Koo, Kevin M., Shen, Ai-Guo, Hu, Ji-Ming and Trau, Matt (2021). Nucleic acid hybridization-based noise suppression for ultraselective multiplexed amplification of mutant variants. Small, 17 (2) 2006370, e2006370. doi: 10.1002/smll.202006370

Direct enhanced detection of multiple circulating tumor dna variants in unprocessed plasma by magnetic-assisted bioelectrocatalytic cycling

Koo, Kevin M. and Trau, Matt (2020). Direct enhanced detection of multiple circulating tumor dna variants in unprocessed plasma by magnetic-assisted bioelectrocatalytic cycling. ACS Sensors, 5 (10), 3217-3225. doi: 10.1021/acssensors.0c01512

Multiomics: The Growing Impact of Micro/Nanomaterial‐Based Systems in Precision Oncology: Translating “Multiomics” Technologies (Adv. Funct. Mater. 37/2020)

Li, Junrong, Wuethrich, Alain, Dey, Shuvashi, Lane, Rebecca E., Sina, Abu A. I., Wang, Jing, Wang, Yuling, Puttick, Simon, Koo, Kevin M. and Trau, Matt (2020). Multiomics: The Growing Impact of Micro/Nanomaterial‐Based Systems in Precision Oncology: Translating “Multiomics” Technologies (Adv. Funct. Mater. 37/2020). Advanced Functional Materials, 30 (37) 2070248. doi: 10.1002/adfm.202070248

Surface-enhanced Raman spectroscopy for cancer immunotherapy applications: opportunities, challenges, and current progress in nanomaterial strategies

Dey, Shuvashis, Trau, Matt and Koo, Kevin M. (2020). Surface-enhanced Raman spectroscopy for cancer immunotherapy applications: opportunities, challenges, and current progress in nanomaterial strategies. Nanomaterials, 10 (6) 1145, 1-15. doi: 10.3390/nano10061145

The role of circulating tumor DNA testing in breast cancer liquid biopsies: getting ready for prime time

Koo, Kevin M. and Mainwaring, Paul N. (2020). The role of circulating tumor DNA testing in breast cancer liquid biopsies: getting ready for prime time. Breast Cancer Management, 9 (1), BMT34. doi: 10.2217/bmt-2020-0003

The growing impact of micro/nanomaterial-based systems in precision oncology: translating “multiomics” technologies

Li, Junrong, Wuethrich, Alain, Dey, Shuvashi, Lane, Rebecca E., Sina, Abu A. I., Wang, Jing, Wang, Yuling, Puttick, Simon, Koo, Kevin M. and Trau, Matt (2020). The growing impact of micro/nanomaterial-based systems in precision oncology: translating “multiomics” technologies. Advanced Functional Materials, 30 (37) 1909306, 1909306. doi: 10.1002/adfm.201909306

Native MicroRNA targets trigger self‐assembly of nanozyme‐patterned hollowed nanocuboids with optimal interparticle gaps for plasmonic‐activated cancer detection

Li, Junrong, Koo, Kevin M., Wang, Yuling and Trau, Matt (2019). Native MicroRNA targets trigger self‐assembly of nanozyme‐patterned hollowed nanocuboids with optimal interparticle gaps for plasmonic‐activated cancer detection. Small, 15 (50) 1904689, 1904689. doi: 10.1002/smll.201904689

Engineering state-of-the-art plasmonic nanomaterials for SERS-based clinical liquid biopsy applications

Wang, Jing, Koo, Kevin M., Wang, Yuling and Trau, Matt (2019). Engineering state-of-the-art plasmonic nanomaterials for SERS-based clinical liquid biopsy applications. Advanced Science, 6 (23) 1900730, 1900730. doi: 10.1002/advs.201900730

Watching SERS glow for multiplex biomolecular analysis in the clinic: A review

Zeng, Yi, Koo, Kevin M., Trau, Matt, Shen, Ai-Guo and Hu, Ji-Ming (2019). Watching SERS glow for multiplex biomolecular analysis in the clinic: A review. Applied Materials Today, 15, 431-444. doi: 10.1016/j.apmt.2019.03.005

Merging new-age biomarkers and nanodiagnostics for precision prostate cancer management

Koo, Kevin M., Mainwaring, Paul N., Tomlins, Scott A. and Trau, Matt (2019). Merging new-age biomarkers and nanodiagnostics for precision prostate cancer management. Nature Reviews Urology, 16 (5), 302-317. doi: 10.1038/s41585-019-0178-2

Phosphoprotein biosensors for monitoring pathological protein structural changes

Ahmed, Mostak, Koo, Kevin M., Mainwaring, Paul N., Carrascosa, Laura G. and Trau, Matt (2019). Phosphoprotein biosensors for monitoring pathological protein structural changes. Trends in Biotechnology, 38 (5), 519-531. doi: 10.1016/j.tibtech.2019.11.006

An integrated multi-molecular sensor for simultaneous BRAFV600E protein and DNA single point mutation detection in circulating tumour cells

Dey, Shuvashis, Koo, Kevin, Wang, Zhaoran, Sina, Abu Ali Ibn, Wuethrich, Alain and Trau, Matt (2018). An integrated multi-molecular sensor for simultaneous BRAFV600E protein and DNA single point mutation detection in circulating tumour cells. Lab on a Chip, 19 (5), 738-748. doi: 10.1039/c8lc00991k

A sample-to-targeted gene analysis biochip for nanofluidic manipulation of solid-phase circulating tumor nucleic acid amplification in liquid biopsies

Koo, Kevin M., Dey, Shuvashis and Trau, Matt (2018). A sample-to-targeted gene analysis biochip for nanofluidic manipulation of solid-phase circulating tumor nucleic acid amplification in liquid biopsies. ACS Sensors, 3 (12) acssensors.8b01011, 2597-2603. doi: 10.1021/acssensors.8b01011

"Mix-to-go" silver colloidal strategy for prostate cancer molecular profiling and risk prediction

Wang, Jing, Koo, Kevin M., Wang, Yuling and Trau, Matt (2018). "Mix-to-go" silver colloidal strategy for prostate cancer molecular profiling and risk prediction. Analytical Chemistry, 90 (21), 12698-12705. doi: 10.1021/acs.analchem.8b02959

Design and clinical verification of surface-enhanced Raman spectroscopy diagnostic technology for individual cancer risk prediction

Koo, Kevin M., Wang, Jing, Richards, Renée S., Farrell, Aine, Yaxley, John W., Samaratunga, Hema, Teloken, Patrick E., Roberts, Matthew J., Coughlin, Geoffrey D., Lavin, Martin F., Mainwaring, Paul N., Wang, Yuling, Gardiner, Robert A. and Trau, Matt (2018). Design and clinical verification of surface-enhanced Raman spectroscopy diagnostic technology for individual cancer risk prediction. ACS Nano, 12 (8), 8362-8371. doi: 10.1021/acsnano.8b03698

Amplification-free multi-RNA-type profiling for cancer risk stratification via alternating current electrohydrodynamic nanomixing

Koo, Kevin M., Dey, Shuvashis and Trau, Matt (2018). Amplification-free multi-RNA-type profiling for cancer risk stratification via alternating current electrohydrodynamic nanomixing. Small, 14 (17) 1704025, e1704025. doi: 10.1002/smll.201704025

Adjustable fluidic nanomixing: amplification-free multi-RNA-type profiling for cancer risk stratification via alternating current electrohydrodynamic nanomixing (Small 17/2018)

Koo, Kevin M., Dey, Shuvashis and Trau, Matt (2018). Adjustable fluidic nanomixing: amplification-free multi-RNA-type profiling for cancer risk stratification via alternating current electrohydrodynamic nanomixing (Small 17/2018). Small, 14 (17) 1870075. doi: 10.1002/smll.201870075

Enabling miniaturised personalised diagnostics: from lab-on-a-chip to lab-in-a-drop

Koo, Kevin M., Wee, Eugene J. H., Wang, Yuling and Trau, Matt (2017). Enabling miniaturised personalised diagnostics: from lab-on-a-chip to lab-in-a-drop. Lab On a Chip, 17 (19), 3200-3220. doi: 10.1039/c7lc00587c

DNA-directed assembly of copper nanoblocks with inbuilt fluorescent and electrochemical properties: Application in simultaneous amplification-free analysis of multiple RNA species

Koo, Kevin M. , Carrascosa, Laura G. and Trau, Matt (2017). DNA-directed assembly of copper nanoblocks with inbuilt fluorescent and electrochemical properties: Application in simultaneous amplification-free analysis of multiple RNA species. Nano Research, 11 (2), 1-13. doi: 10.1007/s12274-017-1706-0

High-speed biosensing strategy for non-invasive profiling of multiple cancer fusion genes in urine

Koo, Kevin M., Wee, Eugene J. H. and Trau, Matt (2017). High-speed biosensing strategy for non-invasive profiling of multiple cancer fusion genes in urine. Biosensors and Bioelectronics, 89 (2), 715-720. doi: 10.1016/j.bios.2016.11.024

A nanoplasmonic label-free surface-enhanced Raman scattering strategy for non-invasive cancer genetic subtyping in patient samples

Wang, Jing, Koo, Kevin M., Wee, Eugene J. H., Wang, Yuling and Trau, Matt (2017). A nanoplasmonic label-free surface-enhanced Raman scattering strategy for non-invasive cancer genetic subtyping in patient samples. Nanoscale, 9 (10), 3496-3503. doi: 10.1039/c6nr09928a

Rapid and sensitive fusion gene detection in prostate cancer urinary specimens by label-free surface-enhanced raman scattering

Koo, Kevin M., McNamara, Benjamin, Wee, Eugene J. H., Wang, Yuling and Trau, Matt (2016). Rapid and sensitive fusion gene detection in prostate cancer urinary specimens by label-free surface-enhanced raman scattering. Journal of Biomedical Nanotechnology, 12 (9), 1798-1805. doi: 10.1166/jbn.2016.2294

A simple, rapid, low-cost technique for naked-eye detection of urine-isolated TMPRSS2:ERG gene fusion RNA

Koo, Kevin M., Wee, Eugene J. H., Mainwaring, Paul N. and Trau, Matt (2016). A simple, rapid, low-cost technique for naked-eye detection of urine-isolated TMPRSS2:ERG gene fusion RNA. Scientific reports, 6 (1) 30722, 30722. doi: 10.1038/srep30722

Amplification-free detection of gene fusions in prostate cancer urinary samples using mRNA-gold affinity interactions

Koo, Kevin M., Carrascosa, Laura G., Shiddiky, Muhammad J. A. and Trau, Matt (2016). Amplification-free detection of gene fusions in prostate cancer urinary samples using mRNA-gold affinity interactions. Analytical Chemistry, 88 (13), 6781-6788. doi: 10.1021/acs.analchem.6b01182

Colorimetric TMPRSS2-ERG gene fusion detection in prostate cancer urinary samples via recombinase polymerase amplification

Koo, Kevin, Wee, Eugene and Trau, Matt (2016). Colorimetric TMPRSS2-ERG gene fusion detection in prostate cancer urinary samples via recombinase polymerase amplification. Theranostics, 6 (9), 1415-1424. doi: 10.7150/thno.15250

Poly(A) extensions of miRNAs for amplification-free electrochemical detection on screen-printed gold electrodes

Koo, Kevin M., Carrascosa, Laura G., Shiddiky, Muhammad J. A. and Trau, Matt (2016). Poly(A) extensions of miRNAs for amplification-free electrochemical detection on screen-printed gold electrodes. Analytical Chemistry, 88 (4), 2000-2005. doi: 10.1021/acs.analchem.5b04795

Toward precision medicine: a cancer molecular subtyping nano-trategy for RNA biomarkers in tumor and urine

Koo, Kevin M., Wee, Eugene J. H., Mainwaring, Paul N., Wang, Yuling and Trau, Matt (2016). Toward precision medicine: a cancer molecular subtyping nano-trategy for RNA biomarkers in tumor and urine. Small, 12 (45), 6233-6242. doi: 10.1002/smll.201602161

DNA-bare gold affinity interactions: mechanism and applications in biosensing

Koo, Kevin M., Sina, Abu A. I., Carrascosa, Laura G., Shiddiky, Muhammad J. A. and Trau, Matt (2015). DNA-bare gold affinity interactions: mechanism and applications in biosensing. Analytical Methods, 7 (17), 1-13. doi: 10.1039/c5ay01479d

Towards rapid and cost-effective point-of-care detection of TMPRSS2:ERG fusion transcripts in urine via a novel methodology

Wee, Eugene J.H., Koo, Kevin M, Mainwaring, Paul N. and Trau, Mattias (2015). Towards rapid and cost-effective point-of-care detection of TMPRSS2:ERG fusion transcripts in urine via a novel methodology. Journal of Clinical Oncology, 33 (15_suppl), 11063-11063. doi: 10.1200/jco.2015.33.15_suppl.11063

eMethylsorb: rapid quantification of DNA methylation in cancer cells on screen-printed gold electrodes

Koo, Kevin M., Sina, Abu Ali Ibn, Carrascosa, Laura G., Shiddiky, Muhammad J. A. and Trau, Matt (2014). eMethylsorb: rapid quantification of DNA methylation in cancer cells on screen-printed gold electrodes. Analyst, 139 (23), 6178-6184. doi: 10.1039/c4an01641f

Microdevices for detecting locus-specific DNA methylation at CpG resolution

Koo, Kevin M., Wee, Eugene, Rauf, Sakandar, Shiddiky, Muhammad J. A. and Trau, Matt (2014). Microdevices for detecting locus-specific DNA methylation at CpG resolution. Biosensors and Bioelectronics, 56, 278-285. doi: 10.1016/j.bios.2014.01.029

mu-eLCR: a microfabricated device for electrochemical detection of DNA base changes in breast cancer cell lines

Wee, Eugene J. H., Rauf, Sakandar, Koo, Kevin, Shiddiky, Muhammad J. A. and Trau, Matt (2013). mu-eLCR: a microfabricated device for electrochemical detection of DNA base changes in breast cancer cell lines. Lab on a Chip, 13 (22), 4385-4391-4385-4391. doi: 10.1039/C3LC50528F

Liquid biopsy in cancer—getting down to the nano level. Can nano-diagnostics lead to comprehensive, accurate, and affordable biomarkers to improve advanced breast (ABC) care?

Mainwaring, Paul N., Grewal, Yadveer S., Koo, Kevin M., Anderson, Will and Korbie, Darren J. (2019). Liquid biopsy in cancer—getting down to the nano level. Can nano-diagnostics lead to comprehensive, accurate, and affordable biomarkers to improve advanced breast (ABC) care?. Advanced Breast Cancer Fifth International Consensus Conference (ABC5), Lisbon, Portugal, 14 - 16 November, 2019. London, United Kingdom: Churchill Livingstone. doi: 10.1016/s0960-9776(19)30638-1

Design and clinical validation of surface enhanced Raman spectroscopy nanodiagnostic technology for urinary prostate cancer risk prediction

Gardiner, F., Koo, K., Wang, J., Richards, R., Farrell, A., Yaxley, J., Samaratunga, H., Teloken, P., Roberts, M., Coughlin, G., Lavin, M., Mainwaring, P., Wang, Y., Gardiner, R. and Trau, M. (2019). Design and clinical validation of surface enhanced Raman spectroscopy nanodiagnostic technology for urinary prostate cancer risk prediction. Annual Scientific Meeting of the Urological Society of Australia and New-Zealand, Brisbane, Australia, 13-16 April 2019 . Chichester, West Sussex, United Kingdom: Wiley-Blackwell.

Towards precision medicine: A cancer molecular subtyping nano-strategy for RNA biomarkers in tumor and urine

Koo, K., Wee, E., Mainwaring, P., Wang, Y. and Trau, M. (2016). Towards precision medicine: A cancer molecular subtyping nano-strategy for RNA biomarkers in tumor and urine. 28th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Munich Germany, November 29 - December 2 2016. United Kingdom: Pergamon. doi: 10.1016/S0959-8049(16)32680-6

Towards rapid and cost-effective point-of-care detection of TMPRSS2:ERG fusion transcripts in urine via a novel methodology

Wee, Eugene J. H., Koo, Kevin M., Mainwaring, Paul N. and Trau, Mattias (2015). Towards rapid and cost-effective point-of-care detection of TMPRSS2:ERG fusion transcripts in urine via a novel methodology. Annual Meeting of the American Society of Clinical Oncology (ASCO), Chicago, IL United States, 29 May-02 June 2015. Alexandria, VA United States: American Society of Clinical Oncology.

Advancing Gene Fusion Detection towards Personalized Cancer Nanodiagnostics

Koo, Maisheng (2018). Advancing Gene Fusion Detection towards Personalized Cancer Nanodiagnostics. PhD Thesis, The Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland. doi: 10.14264/uql.2018.716