Niu, Xueming, Zhang, Zhen, Zhou, Quan, Wuethrich, Alain, Lobb, Richard and Trau, Matt (2024). Analysis of secreted small extracellular vesicles from activated human microglial cell lines reveals distinct pro‐ and anti‐inflammatory proteomic profiles. PROTEOMICS, e2300094. doi: 10.1002/pmic.202300094
Journal Article: A mesoporous gold biosensor to investigate immune checkpoint protein heterogeneity in single lung cancer cells
Ahmed, Emtiaz, Masud, Mostafa Kamal, Komatineni, Prathyusha, Dey, Shuvashis, Lobb, Richard, Hossain, Md Shahriar A., Möller, Andreas, Yamauchi, Yusuke, Sina, Abu Ali Ibn and Trau, Matt (2024). A mesoporous gold biosensor to investigate immune checkpoint protein heterogeneity in single lung cancer cells. Biosensors and Bioelectronics, 249 115984, 115984. doi: 10.1016/j.bios.2023.115984
Journal Article: Tracking the EMT-like phenotype switching during targeted therapy in melanoma by analyzing extracellular vesicle phenotypes
Zhou, Quan, Wang, Jing, Zhang, Zhen, Wuethrich, Alain, Lobb, Richard J. and Trau, Matt (2023). Tracking the EMT-like phenotype switching during targeted therapy in melanoma by analyzing extracellular vesicle phenotypes. Biosensors and Bioelectronics, 244 115819, 115819. doi: 10.1016/j.bios.2023.115819
nanoIMPAC: Monitoring immune toxicities and tumour immune evasion in lung cancer
(2022–2025) Cancer Australia
(2021–2024) University of Newcastle
Engineering therapeutic cells for pan-cancer diagnosis and eradication
(2019–2022) CSIRO Synthetic Biology Fellowship
The investigation of microglial activation in brain cancer and brain metastasis by an integrated nano-sensor
Doctor Philosophy
Digital Nanotechnologies to track molecular aberrations in cancer
Doctor Philosophy
Utilising extracellular vesicles for the diagnosis of lung cancer.
Doctor Philosophy
Size exclusion chromatography: a simple and reliable method for exosome purification
Lobb, Richard and Moller, Andreas (2017). Size exclusion chromatography: a simple and reliable method for exosome purification. In Winston Patrick Kuo and Shidong Jia (Ed.), Extracellular vesicles: methods and protocols (pp. 105-110) New York, NY, United States: Humana Press. doi:10.1007/978-1-4939-7253-1_9
Niu, Xueming, Zhang, Zhen, Zhou, Quan, Wuethrich, Alain, Lobb, Richard and Trau, Matt (2024). Analysis of secreted small extracellular vesicles from activated human microglial cell lines reveals distinct pro‐ and anti‐inflammatory proteomic profiles. PROTEOMICS, e2300094. doi: 10.1002/pmic.202300094
Ahmed, Emtiaz, Masud, Mostafa Kamal, Komatineni, Prathyusha, Dey, Shuvashis, Lobb, Richard, Hossain, Md Shahriar A., Möller, Andreas, Yamauchi, Yusuke, Sina, Abu Ali Ibn and Trau, Matt (2024). A mesoporous gold biosensor to investigate immune checkpoint protein heterogeneity in single lung cancer cells. Biosensors and Bioelectronics, 249 115984, 115984. doi: 10.1016/j.bios.2023.115984
Zhou, Quan, Wang, Jing, Zhang, Zhen, Wuethrich, Alain, Lobb, Richard J. and Trau, Matt (2023). Tracking the EMT-like phenotype switching during targeted therapy in melanoma by analyzing extracellular vesicle phenotypes. Biosensors and Bioelectronics, 244 115819, 115819. doi: 10.1016/j.bios.2023.115819
Ahmed, Emtiaz, Shanmugasundaram, Karthik Balaji, Li, Junrong, Behren, Andreas, Lobb, Richard, Möller, Andreas, Wuethrich, Alain, Dey, Shuvashis, Sina, Abu Ali Ibn and Trau, Matt (2023). A microfluidic liquid biopsy platform to monitor protein biomarker heterogeneity in single circulating therapy‐resistance cancer cell. Advanced Sensor Research, 2 (12). doi: 10.1002/adsr.202300059
Li, Junrong, Howard, Christopher B., Dey, Shuvashis, Lowry, Kym, Whiley, David M., Puttick, Simon, Rose, Stephen, Lobb, Richard J., Wuethrich, Alain, Edwardraja, Selvakumar and Trau, Matt (2023). A universal reagent for detection of emerging diseases using bioengineered multifunctional yeast nanofragments. Nature Nanotechnology, 18 (10), 1222-1229. doi: 10.1038/s41565-023-01415-1
Lobb, Richard J., Visan, Kekoolani S., Wu, Li-Ying, Norris, Emma L., Hastie, Marcus L., Everitt, Sarah, Yang, Ian A., Bowman, Rayleen V., Siva, Shankar, Larsen, Jill E., Gorman, Jeffrey J., MacManus, Michael, Leimgruber, Antoine, Fong, Kwun M. and Möller, Andreas (2023). An epithelial-to-mesenchymal transition induced extracellular vesicle prognostic signature in non-small cell lung cancer. Communications biology, 6 (1) 68, 68. doi: 10.1038/s42003-022-04350-4
Li, Junrong, Sina, Abu A. I., Antaw, Fiach, Fielding, David, Möller, Andreas, Lobb, Richard, Wuethrich, Alain and Trau, Matt (2023). Digital decoding of single extracellular vesicle phenotype differentiates early malignant and benign lung lesions. Advanced Science, 10 (1) 2204207, e2204207. doi: 10.1002/advs.202204207
Visan, Kekoolani S., Lobb, Richard J., Ham, Sunyoung, Lima, Luize G., Palma, Carlos, Edna, Chai Pei Zhi, Wu, Li-Ying, Gowda, Harsha, Datta, Keshava K., Hartel, Gunter, Salomon, Carlos and Möller, Andreas (2022). Comparative analysis of tangential flow filtration and ultracentrifugation, both combined with subsequent size exclusion chromatography, for the isolation of small extracellular vesicles. Journal of Extracellular Vesicles, 11 (9) 12266, 12266. doi: 10.1002/jev2.12266
Blood-derived extracellular vesicle-associated miR-3182 detects non-small cell lung cancer patients
Visan, Kekoolani S., Lobb, Richard J., Wen, Shu Wen, Bedo, Justin, Lima, Luize G., Krumeich, Sophie, Palma, Carlos, Ferguson, Kaltin, Green, Ben, Niland, Colleen, Cloonan, Nicole, Simpson, Peter T., McCart Reed, Amy E., Everitt, Sarah J., MacManus, Michael P., Hartel, Gunter, Salomon, Carlos, Lakhani, Sunil R., Fielding, David and Möller, Andreas (2022). Blood-derived extracellular vesicle-associated miR-3182 detects non-small cell lung cancer patients. Cancers, 14 (1) 257, 257. doi: 10.3390/cancers14010257
Farokhinejad, Fahimeh, Lane, Rebecca E., Lobb, Richard J., Edwardraja, Selvakumar, Wuethrich, Alain, Howard, Christopher B. and Trau, Matt (2021). Generation of nanoyeast single-chain variable fragments as high-avidity biomaterials for dengue virus detection. ACS Biomaterials Science and Engineering, 7 (12) acsbiomaterials.1c01001, 5850-5860. doi: 10.1021/acsbiomaterials.1c01001
Li, Junrong, Wuethrich, Alain, Edwardraja, Selvakumar, Lobb, Richard J., Puttick, Simon, Rose, Stephen, Howard, Christopher B. and Trau, Matt (2021). Amplification-free SARS-CoV-2 detection using nanoyeast-scFv and ultrasensitive plasmonic nanobox-integrated nanomixing microassay. Analytical Chemistry, 93 (29) acs.analchem.1c01657, 10251-10260. doi: 10.1021/acs.analchem.1c01657
Wang, Jing, Wuethrich, Alain, Lobb, Richard J., Antaw, Fiach, Sina, Abu Ali Ibn, Lane, Rebecca E., Zhou, Quan, Zieschank, Chloe, Bell, Caroline, Bonazzi, Vanessa F., Aoude, Lauren G., Everitt, Sarah, Yeo, Belinda, Barbour, Andrew P., Möller, Andreas and Trau, Matt (2021). Characterizing the heterogeneity of small extracellular vesicle populations in multiple cancer types via an ultrasensitive chip. ACS Sensors, 6 (9) acssensors.1c00358, 3182-3194. doi: 10.1021/acssensors.1c00358
Lima, Luize G., Ham, Sunyoung, Shin, Hyunku, Chai, Edna P. Z., Lek, Erica S. H., Lobb, Richard J., Müller, Alexandra F., Mathivanan, Suresh, Yeo, Belinda, Choi, Yeonho, Parker, Belinda S. and Möller, Andreas (2021). Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution. Nature Communications, 12 (1) 3543, 1-12. doi: 10.1038/s41467-021-23946-8
The evolving translational potential of small extracellular vesicles in cancer
Möller, Andreas and Lobb, Richard J. (2020). The evolving translational potential of small extracellular vesicles in cancer. Nature Reviews Cancer, 20 (12), 697-709. doi: 10.1038/s41568-020-00299-w
The role of exosomes in the promotion of epithelial-to-mesenchymal transition and metastasis
Visan, Kekoolani S., Lobb, Richard J. and Moller, Andreas (2020). The role of exosomes in the promotion of epithelial-to-mesenchymal transition and metastasis. Frontiers in Bioscience - Landmark, 25 (6) 4846, 1022-1057. doi: 10.2741/4846
Breast cancer-derived exosomes reflect the cell-of-origin phenotype
Wen, Shu Wen, Lima, Luize G., Lobb, Richard J., Norris, Emma L., Hastie, Marcus L., Krumeich, Sophie and Möller, Andreas (2019). Breast cancer-derived exosomes reflect the cell-of-origin phenotype. Proteomics, 19 (8) 1800180, 1800180. doi: 10.1002/pmic.201800180
Wiegmans, Adrian P., Saunus, Jodi M., Ham, Sunyoung, Lobb, Richard J., Kutasovic, Jamie R., Dalley, Andrew J., Miranda, Mariska, Atkinson, Caroline, Foliaki, Simote T., Ferguson, Kaltin, Niland, Colleen, Johnstone, Cameron N., Lewis, Victoria, Collins, Steven, Lakhani, Sunil R., Al-Ejeh, Fares and Möller, Andreas (2019). Secreted cellular prion protein binds doxorubicin and correlates with anthracycline resistance in breast cancer. JCI Insight, 5 (6). doi: 10.1172/jci.insight.124092
Lobb, Richard J., Jacobson, Gregory M., Cursons, Ray T. and Jameson, Michael B. (2018). The interaction of selenium with chemotherapy and radiation on normal and malignant human mononuclear blood cells. International Journal of Molecular Sciences, 19 (10) 3167. doi: 10.3390/ijms19103167
Breast cancer-derived exosomes alter macrophage polarization via gp130/STAT3 signaling
Ham, Sunyoung, Lima, Luize G., Chai, Edna Pei Zhi, Muller, Alexandra, Lobb, Richard J., Krumeich, Sophie, Wen, Shu Wen, Wiegmans, Adrian P. and Moeller, Andreas (2018). Breast cancer-derived exosomes alter macrophage polarization via gp130/STAT3 signaling. Frontiers in Immunology, 9 (MAY) 871, 871. doi: 10.3389/fimmu.2018.00871
Lobb, Richard J., Hastie, Marcus L., Norris, Emma L., van Amerongen, Rosa, Gorman, Jeffrey J. and Möller, Andreas (2017). Oncogenic transformation of lung cells results in distinct exosome protein profile similar to the cell of origin. Proteomics, 17 (23-24) 1600432, 1-10. doi: 10.1002/pmic.201600432
Exosomes derived from mesenchymal non-small cell lung cancer cells promote chemoresistance
Lobb, Richard J., van Amerongen, Rosa, Wiegmans, Adrian, Ham, Sunyoung, Larsen, Jill E. and Moller, Andreas (2017). Exosomes derived from mesenchymal non-small cell lung cancer cells promote chemoresistance. International Journal of Cancer, 141 (3), 614-620. doi: 10.1002/ijc.30752
An electrochemical method for the detection of disease-apecific exosomes
Yadav, Sharda, Boriachek, Kseniia, Islam, Md Nazmul, Lobb, Richard, Moller, Andreas, Hill, Michelle M., Hossain, Md Shahriar Al, Nguyen, Nam-Trung and Shiddiky, Muhammad J. A. (2017). An electrochemical method for the detection of disease-apecific exosomes. ChemElectroChem, 4 (4), 967-971. doi: 10.1002/celc.201600391
Wang, Xiangju, Wilkinson, Ray, Kildey, Katrina, Potriquet, Jeremy, Mulvenna, Jason, Lobb, Richard J., Moller, Andreas, Cloonan, Nicole, Mukhopadhyay, Pamela, Kassianos, Andrew J. and Healy, Helen (2017). Unique molecular profile of exosomes derived from primary human proximal tubular epithelial cells under diseased conditions. Journal of Extracellular Vesicles, 6 (1) 1314073, 1314073-1314073. doi: 10.1080/20013078.2017.1314073
Exosomes: key mediators of metastasis and pre-metastatic niche formation
Lobb, Richard J., Lima, Luize G. and Moller, Andreas (2017). Exosomes: key mediators of metastasis and pre-metastatic niche formation. Seminars in Cell and Developmental Biology, 67, 3-10. doi: 10.1016/j.semcdb.2017.01.004
The biodistribution and immune suppressive effects of breast cancer-derived exosomes
Wen, Shu Wen, Sceneay, Jaclyn, Lima, Luize Goncalves, Wong, Christina S. F., Becker, Melanie, Krumeich, Sophie, Lobb, Richard J., Castillo, Vanessa, Wong, Ke Ni, Ellis, Sarah, Parker, Belinda S. and Moller, Andreas (2016). The biodistribution and immune suppressive effects of breast cancer-derived exosomes. Cancer Research, 76 (23), 6816-6827. doi: 10.1158/0008-5472.CAN-16-0868
Siva, Shankar, Lobachevsky, Pavel, MacManus, Michael P., Kron, Tomas, Möller, Andreas, Lobb, Richard J., Ventura, Jessica, Best, Nickala, Smith, Jai, Ball, David and Martin, Olga A. (2016). Radiotherapy for non-small cell lung cancer induces DNA damage response in both irradiated and out-of-field normal tissues. Clinical Cancer Research, 22 (19), 4817-4826. doi: 10.1158/1078-0432.CCR-16-0138
Optimized exosome isolation protocol for cell culture supernatant and human plasma
Lobb, Richard J., Becker, Melanie, Wen, Shu Wen, Wong, Christina S. F., Wiegmans, Adrian P., Leimgruber, Antione and Moller, Andreas (2015). Optimized exosome isolation protocol for cell culture supernatant and human plasma. Journal of Extracellular Vesicles, 4 (1) 27031, 27031. doi: 10.3402/jev.v4.27031
Exosomes in cancer metastasis: Novel targets for diagnosis and therapy?
Wen, Shu Wen, Lobb, Richard and Moller, Andreas (2014). Exosomes in cancer metastasis: Novel targets for diagnosis and therapy?. Cancer Forum, 38 (2), 116-120.
Purification and Analysis of Exosomes Derived From Primary Human Proximal Epithelial Cells (Ptec)
Wang, X., Kassianos, A. J., Potriquet, J., Lobb, R., Wilkinson, R. and Healy, H. (2015). Purification and Analysis of Exosomes Derived From Primary Human Proximal Epithelial Cells (Ptec). 51st Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Canberra, Australia, 7-9 September 2015. HOBOKEN: WILEY-BLACKWELL.
Lobb, Richard John (2018). Exosomes in the disease progression of non-small cell lung cancer (NSCLC) patients. Exosomes as biomarkers in NSCLC. PhD Thesis, School of Medicine, The University of Queensland. doi: 10.14264/uql.2018.236
nanoIMPAC: Monitoring immune toxicities and tumour immune evasion in lung cancer
(2022–2025) Cancer Australia
(2021–2024) University of Newcastle
Engineering therapeutic cells for pan-cancer diagnosis and eradication
(2019–2022) CSIRO Synthetic Biology Fellowship
The investigation of microglial activation in brain cancer and brain metastasis by an integrated nano-sensor
Doctor Philosophy — Principal Advisor
Other advisors:
Digital Nanotechnologies to track molecular aberrations in cancer
Doctor Philosophy — Associate Advisor
Other advisors:
Utilising extracellular vesicles for the diagnosis of lung cancer.
Doctor Philosophy — Associate Advisor
Other advisors:
Monitoring molecular heterogeneity in extracellular vesicles and understanding cellular communications during treatment procedure
Doctor Philosophy — Associate Advisor
Other advisors: