The University of Queensland

An E-cadherin-actin clutch translates the mechanical force of cortical flow for cell-cell contact to inhibit epithelial cell locomotion

Noordstra, Ivar, Hermoso, Mario Díez, Schimmel, Lilian, Bonfim-Melo, Alexis, Currin-Ross, Denni, Duong, Cao Nguyen, Kalappurakkal, Joseph Mathew, Morris, Richard G., Vestweber, Dietmar, Mayor, Satyajit, Gordon, Emma, Roca-Cusachs, Pere and Yap, Alpha S. (2023). An E-cadherin-actin clutch translates the mechanical force of cortical flow for cell-cell contact to inhibit epithelial cell locomotion. Developmental Cell, 58 (18), 1748-1763.e6. doi: 10.1016/j.devcel.2023.06.011

Successful invasion of Trypanosoma cruzi trypomastigotes is dependent on host cell actin cytoskeleton

Bonifácio, Bruno Souza, Bonfim‐Melo, Alexis, Mortara, Renato Arruda and Ferreira, Éden Ramalho (2022). Successful invasion of Trypanosoma cruzi trypomastigotes is dependent on host cell actin cytoskeleton. Journal of Eukaryotic Microbiology, 69 (3) e12903, e12903. doi: 10.1111/jeu.12903

Rapid lamellipodial responses by neighbor cells drive epithelial sealing in response to pyroptotic cell death

Bonfim-Melo, Alexis, Noordstra, Ivar, Gupta, Shafali, Chan, Amy H., Jones, Mathew J.K., Schroder, Kate and Yap, Alpha S. (2022). Rapid lamellipodial responses by neighbor cells drive epithelial sealing in response to pyroptotic cell death. Cell Reports, 38 (5) 110316, 110316. doi: 10.1016/j.celrep.2022.110316

Regulating life after death: how mechanical communication mediates the epithelial response to apoptosis

Bonfim-Melo, Alexis, Duszyc, Kinga, Gomez, Guillermo A. and Yap, Alpha S. (2022). Regulating life after death: how mechanical communication mediates the epithelial response to apoptosis. The European Physical Journal E, 45 (1) 9, 9. doi: 10.1140/epje/s10189-022-00163-9

Trypanosoma cruzi extracellular amastigotes engage Rac1 and Cdc42 to invade RAW macrophages

Medina, Camila Macedo, Ferreira, Éden Ramalho, Bonifácio, Bruno Souza, Mortara, Renato Arruda and Bonfim-Melo, Alexis (2021). Trypanosoma cruzi extracellular amastigotes engage Rac1 and Cdc42 to invade RAW macrophages. Microbes and Infection, 23 (8) 104837, 104837. doi: 10.1016/j.micinf.2021.104837

Parasite-mediated remodeling of the host microfilament cytoskeleton enables rapid egress of Trypanosoma cruzi following membrane rupture

Ferreira, Eden R., Bonfim-Melo, Alexis, Burleigh, Barbara A., Costales, Jaime A., Tyler, Kevin M. and Mortara, Renato A. (2021). Parasite-mediated remodeling of the host microfilament cytoskeleton enables rapid egress of Trypanosoma cruzi following membrane rupture. mBio, 12 (3) e00988-21. doi: 10.1128/mbio.00988-21

Genomic properties and temporal analysis of the interaction of an invasive Escherichia albertii with epithelial cells

Romão, Fabiano T., Martins, Fernando H., Hernandes, Rodrigo T., Ooka, Tadasuke, Santos, Fernanda F., Yamamoto, Denise, Bonfim-Melo, Alexis, Jones, Nina, Hayashi, Tetsuya, Elias, Waldir P., Sperandio, Vanessa and Gomes, Tânia A. T. (2020). Genomic properties and temporal analysis of the interaction of an invasive Escherichia albertii with epithelial cells. Frontiers in Cellular and Infection Microbiology, 10 571088, 1-14. doi: 10.3389/fcimb.2020.571088

Trypanosoma cruzi extracellular amastigotes selectively trigger the PI3K/Akt and Erk pathways during HeLa cell invasion

Ferreira, Bianca Lima, Ferreira, Éden Ramalho, Bonfim-Melo, Alexis, Mortara, Renato Arruda and Bahia, Diana (2019). Trypanosoma cruzi extracellular amastigotes selectively trigger the PI3K/Akt and Erk pathways during HeLa cell invasion. Microbes and Infection, 21 (10), 485-489. doi: 10.1016/j.micinf.2019.06.003

Host cell protein LAMP‐2 is the receptor for Trypanosoma cruzi surface molecule gp82 that mediates invasion

Rodrigues, João Paulo Ferreira, Souza Onofre, Thiago, Barbosa, Bruno Couto, Ferreira, Éden Ramalho, Bonfim‐Melo, Alexis and Yoshida, Nobuko (2019). Host cell protein LAMP‐2 is the receptor for Trypanosoma cruzi surface molecule gp82 that mediates invasion. Cellular Microbiology, 21 (5) e13003, e13003. doi: 10.1111/cmi.13003

Amastigote synapse: the tricks of Trypanosoma cruzi extracellular amastigotes

Bonfim-Melo, Alexis, Ferreira, Eden R., Florentino, Pilar T.V. and Mortara, Renato A. (2018). Amastigote synapse: the tricks of Trypanosoma cruzi extracellular amastigotes. Frontiers in Microbiology, 9 (JUN) 1341. doi: 10.3389/fmicb.2018.01341

Rac1/WAVE2 and Cdc42/N-WASP participation in actin-dependent host cell invasion by extracellular amastigotes of Trypanosoma cruzi

Bonfim-Melo, Alexis, Ferreira, Éden R. and Mortara, Renato A. (2018). Rac1/WAVE2 and Cdc42/N-WASP participation in actin-dependent host cell invasion by extracellular amastigotes of Trypanosoma cruzi. Frontiers in Microbiology, 9 (FEB) 360, 360. doi: 10.3389/fmicb.2018.00360

ERM proteins play distinct roles in cell invasion by extracellular amastigotes of Trypanosoma cruzi

Ferreira, Éden R., Bonfim-Melo, Alexis, Cordero, Esteban M. and Mortara, Renato A. (2017). ERM proteins play distinct roles in cell invasion by extracellular amastigotes of Trypanosoma cruzi. Frontiers in Microbiology, 8 (NOV) 2230, 2230. doi: 10.3389/fmicb.2017.02230

Candida albicans: the ability to invade epithelial cells and survive under oxidative stress is unlinked to hyphal length

Maza, Paloma K., Bonfim-Melo, Alexis, Padovan, Ana C.B., Mortara, Renato A., Orikaza, Cristina M., Ramos, Lilian M. Damas, Moura, Tauany R., Soriani, Frederico M., Almeida, Ricardo S., Suzuki, Erika and Bahia, Diana (2017). Candida albicans: the ability to invade epithelial cells and survive under oxidative stress is unlinked to hyphal length. Frontiers in Microbiology, 8 (JUL) 1235, 1235. doi: 10.3389/fmicb.2017.01235

Genetic relatedness and virulence properties of enteropathogenic Escherichia coli strains of serotype O119: H6 expressing localized adherence or localized and aggregative adherence-like patterns on HeLa cells

Garcia, Bruna G., Ooka, Tadasuke, Gotoh, Yasuhiro, Vieira, Mônica A.M., Yamamoto, Denise, Ogura, Yoshitoshi, Girão, Dennys M., Sampaio, Suely C.F., Melo, Alexis Bonfim, Irino, Kinue, Hayashi, Tetsuya and Gomes, Tânia A.T. (2016). Genetic relatedness and virulence properties of enteropathogenic Escherichia coli strains of serotype O119: H6 expressing localized adherence or localized and aggregative adherence-like patterns on HeLa cells. International Journal of Medical Microbiology, 306 (3), 152-164. doi: 10.1016/j.ijmm.2016.02.008

Unique behavior of Trypanosoma cruzi mevalonate kinase: a conserved glycosomal enzyme involved in host cell invasion and signaling

Ferreira, Éden Ramalho, Horjales, Eduardo, Bonfim-Melo, Alexis, Cortez, Cristian, Da Silva, Claudio Vieira, De Groote, Michel, Sobreira, Tiago José Paschoal, Cruz, Mário Costa, Lima, Fabio Mitsuo, Cordero, Esteban Mauricio, Yoshida, Nobuko, Da Silveira, José Franco, Mortara, Renato Arruda and Bahia, Diana (2016). Unique behavior of Trypanosoma cruzi mevalonate kinase: a conserved glycosomal enzyme involved in host cell invasion and signaling. Scientific Reports, 6 (1) 24610. doi: 10.1038/srep24610

Trypanosoma cruzi extracellular amastigotes trigger the protein kinase D1-cortactin-actin pathway during cell invasion

Bonfim-Melo, Alexis, Zanetti, Bianca Ferrarini, Ferreira, Éden Ramalho, Vandoninck, Sandy, Han, Sang Won, Van Lint, Johan, Mortara, Renato Arruda and Bahia, Diana (2015). Trypanosoma cruzi extracellular amastigotes trigger the protein kinase D1-cortactin-actin pathway during cell invasion. Cellular Microbiology, 17 (12), 1797-1810. doi: 10.1111/cmi.12472

An historical perspective on how advances in microscopic imaging contributed to understanding the Leishmania Spp. and Trypanosoma cruzi host-parasite relationship

Florentino, P. T.V., Real, F., Bonfim-Melo, A., Orikaza, C. M., Ferreira, E. R., Pessoa, C. C., Lima, B. R., Sasso, G. R.S. and Mortara, R. A. (2014). An historical perspective on how advances in microscopic imaging contributed to understanding the Leishmania Spp. and Trypanosoma cruzi host-parasite relationship. BioMed Research International, 2014 565291, 1-16. doi: 10.1155/2014/565291

Trypanosoma cruzi extracellular amastigotes and host cell signaling: more pieces to the puzzle

Ferreira, Éden R., Bonfim-Melo, Alexis, Mortara, Renato A. and Bahia, Diana (2012). Trypanosoma cruzi extracellular amastigotes and host cell signaling: more pieces to the puzzle. Frontiers in Immunology, 3 (NOV) Article 363. doi: 10.3389/fimmu.2012.00363

Proteins of Leishmania (Viannia) shawi confer protection associated with Th1 immune response and memory generation

Passero, Luiz Felipe D, Carvalho, Ana Kely, Bordon, Maria Lac, Bonfim-Melo, Alexis, Carvalho, Karina, Kallás, Esper G, Santos, Bianca Ba, Toyama, Marcos H, Paes-Leme, Adriana, Corbett, Carlos Ep and Laurenti, Márcia D (2012). Proteins of Leishmania (Viannia) shawi confer protection associated with Th1 immune response and memory generation. Parasites and Vectors, 5 (1) 64. doi: 10.1186/1756-3305-5-64

Leishmania (Viannia) shawi purified antigens confer protection against murine cutaneous leishmaniasis

Passero, Luiz Felipe Domingues, Carvalho, Ana Kely, Bordon, Maria Luiza A. C., Bonfim-Melo, Alexis, Toyama, Marcos Hikari, Corbett, Carlos Eduardo Pereira and Laurenti, Márcia Dalastra (2012). Leishmania (Viannia) shawi purified antigens confer protection against murine cutaneous leishmaniasis. Inflammation Research, 61 (3), 255-263. doi: 10.1007/s00011-011-0407-5

Evaluation of anti-inflammatory activity of derivatives from aerial parts of Baccharis uncinella

Zalewski, Cynthia A., Passero, Luiz Felipe D., Melo, Alexis S. R. B., Corbett, Carlos Eduardo P., Laurenti, Mãrcia D., Toyama, Marcos H., Toyama, Daniela O., Romoff, Paulete, Fávero, Oriana A. and Lago, João Henrique G. (2011). Evaluation of anti-inflammatory activity of derivatives from aerial parts of Baccharis uncinella. Pharmaceutical Biology, 49 (6), 602-607. doi: 10.3109/13880209.2010.537828

Anti-leishmanial effects of purified compounds from aerial parts of Baccharis uncinella C. DC. (Asteraceae)

Passero, Luiz Felipe D., Bonfim-Melo, Alexis, Corbett, Carlos Eduardo P., Laurenti, Márcia D., Toyama, Marcos H., De Toyama, Daniela O., Romoff, Paulete, Fávero, Oriana A., Dos Grecco, Simone S., Zalewsky, Cynthia A. and Lago, João Henrique G. (2011). Anti-leishmanial effects of purified compounds from aerial parts of Baccharis uncinella C. DC. (Asteraceae). Parasitology Research, 108 (3), 529-536. doi: 10.1007/s00436-010-2091-8