Dr Johannes Zuegg

Senior Research Fellow

Institute for Molecular Bioscience
j.zuegg@imb.uq.edu.au
+61 7 334 62994

Overview

Qualifications

  • Doctor of Philosophy of Chemistry and Biochemistry, Technische Universität Graz

Publications

  • van Niekerk, Annick, Joseph, M. Cassiem, Kavanagh, Angela, Dinh, Hue, Swarts, Andrew J., Mapolie, Selwyn F., Zuegg, Johannes, Cain, Amy K., Elliott, Alysha G., Blaskovich, Mark A. T. and Frei, Angelo (2023). The antimicrobial properties of Pd(II)‐ and Ru(II)‐pyta complexes. ChemBioChem, 24 (19) e202300247, e202300247. doi: 10.1002/cbic.202300247

  • Overman, Jeroen, Fontaine, Frank, Moustaqil, Mehdi, Mittal, Deepak, Sierecki, Emma, Sacilotto, Natalia, Zuegg, Johannes, Robertson, Avril AB, Holmes, Kelly, Salim, Angela A, Mamidyala, Sreeman, Butler, Mark S, Robinson, Ashley S, Lesieur, Emmanuelle, Johnston, Wayne, Alexandrov, Kirill, Black, Brian L, Hogan, Benjamin M, De Val, Sarah, Capon, Robert J, Carroll, Jason S, Bailey, Timothy L, Koopman, Peter, Jauch, Ralf, Cooper, Matthew A, Gambin, Yann and Francois, Mathias (2023). Correction: Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. eLife, 12 ARTN e90408. doi: 10.7554/elife.90408

  • Frei, Angelo, Verderosa, Anthony D., Elliott, Alysha G., Zuegg, Johannes and Blaskovich, Mark A. T. (2023). Metals to combat antimicrobial resistance. Nature Reviews Chemistry, 7 (3), 1-23. doi: 10.1038/s41570-023-00463-4

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Supervision

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Publications

Journal Article

  • van Niekerk, Annick, Joseph, M. Cassiem, Kavanagh, Angela, Dinh, Hue, Swarts, Andrew J., Mapolie, Selwyn F., Zuegg, Johannes, Cain, Amy K., Elliott, Alysha G., Blaskovich, Mark A. T. and Frei, Angelo (2023). The antimicrobial properties of Pd(II)‐ and Ru(II)‐pyta complexes. ChemBioChem, 24 (19) e202300247, e202300247. doi: 10.1002/cbic.202300247

  • Overman, Jeroen, Fontaine, Frank, Moustaqil, Mehdi, Mittal, Deepak, Sierecki, Emma, Sacilotto, Natalia, Zuegg, Johannes, Robertson, Avril AB, Holmes, Kelly, Salim, Angela A, Mamidyala, Sreeman, Butler, Mark S, Robinson, Ashley S, Lesieur, Emmanuelle, Johnston, Wayne, Alexandrov, Kirill, Black, Brian L, Hogan, Benjamin M, De Val, Sarah, Capon, Robert J, Carroll, Jason S, Bailey, Timothy L, Koopman, Peter, Jauch, Ralf, Cooper, Matthew A, Gambin, Yann and Francois, Mathias (2023). Correction: Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. eLife, 12 ARTN e90408. doi: 10.7554/elife.90408

  • Frei, Angelo, Verderosa, Anthony D., Elliott, Alysha G., Zuegg, Johannes and Blaskovich, Mark A. T. (2023). Metals to combat antimicrobial resistance. Nature Reviews Chemistry, 7 (3), 1-23. doi: 10.1038/s41570-023-00463-4

  • Hart, Christopher J. S., Riches, Andrew G., Tiash, Snigdha, Clapper, Erin, Ramu, Soumya, Zuegg, Johannes, Ryan, John H. and Skinner-Adams, Tina S. (2022). A subset screen of the Compounds Australia Scaffold Library identifies 7-acylaminodibenzoxazepinones as potent and selective hits for anti-Giardia drug discovery. Biomedicines, 10 (12) 3182, 1-14. doi: 10.3390/biomedicines10123182

  • Frei, Angelo, Elliott, Alysha G., Kan, Alex, Dinh, Hue, Bräse, Stefan, Bruce, Alice E., Bruce, Mitchell R., Chen, Feng, Humaidy, Dhirgam, Jung, Nicole, King, A. Paden, Lye, Peter G., Maliszewska, Hanna K., Mansour, Ahmed M., Matiadis, Dimitris, Muñoz, María Paz, Pai, Tsung-Yu, Pokhrel, Shyam, Sadler, Peter J., Sagnou, Marina, Taylor, Michelle, Wilson, Justin J., Woods, Dean, Zuegg, Johannes, Meyer, Wieland, Cain, Amy K., Cooper, Matthew A. and Blaskovich, Mark A. T. (2022). Metal complexes as antifungals? From a crowd-sourced compound library to the first in vivo experiments. JACS Au, 2 (10), 2277-2294. doi: 10.1021/jacsau.2c00308

  • Blaskovich, Mark A.T., Hansford, Karl A., Butler, Mark S., Ramu, Soumya, Kavanagh, Angela M., Jarrad, Angie M., Prasetyoputri, Anggia, Pitt, Miranda E., Huang, Johnny X., Lindahl, Fredrik, Ziora, Zyta M., Bradford, Tanya, Muldoon, Craig, Rajaratnam, Premraj, Pelingon, Ruby, Edwards, David J., Zhang, Bing, Amado, Maite, Elliott, Alysha G., Zuegg, Johannes, Coin, Lachlan, Woischnig, Anne-Kathrin, Khanna, Nina, Breidenstein, Elena, Stincone, Anna, Mason, Clive, Khan, Nawaz, Cho, Hye-Kyung, Karau, Melissa J. ... Cooper, Matthew A. (2022). A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections. Science Translational Medicine, 14 (662) abj2381. doi: 10.1126/scitranslmed.abj238

  • Blaskovich, Mark A.T., Hansford, Karl A., Butler, Mark S., Ramu, Soumya, Kavanagh, Angela M., Jarrad, Angie M., Prasetyoputri, Anggia, Pitt, Miranda E., Huang, Johnny X., Lindahl, Fredrik, Ziora, Zyta M., Bradford, Tanya, Muldoon, Craig, Rajaratnam, Premraj, Pelingon, Ruby, Edwards, David J., Zhang, Bing, Amado, Maite, Elliott, Alysha G., Zuegg, Johannes, Coin, Lachlan, Woischnig, Anne-Kathrin, Khanna, Nina, Breidenstein, Elena, Stincone, Anna, Mason, Clive, Khan, Nawaz, Cho, Hye-Kyung, Karau, Melissa J. ... Cooper, Matthew A. (2022). A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections. Science Translational Medicine, 14 (662) abj2381, 1-16. doi: 10.1126/scitranslmed.abj2381

  • Medina-Franco, José L., López-López, Edgar, Andrade, Emma, Ruiz-Azuara, Lena, Frei, Angelo, Guan, Davy, Zuegg, Johannes and Blaskovich, Mark A.T. (2022). Bridging informatics and medicinal inorganic chemistry: toward a database of metallodrugs and metallodrug candidates. Drug Discovery Today, 27 (5), 1420-1430. doi: 10.1016/j.drudis.2022.02.021

  • Baker, Jennifer R., Cossar, Peter J., Blaskovich, Mark A. T., Elliott, Alysha G., Zuegg, Johannes, Cooper, Matthew A., Lewis, Peter J. and McCluskey, Adam (2022). Amino alcohols as potential antibiotic and antifungal leads. Molecules, 27 (7) 2050. doi: 10.3390/molecules27072050

  • De Oliveira, David M. P., Forde, Brian M., Phan, Minh-Duy, Steiner, Bernhard, Zhang, Bing, Zuegg, Johannes, El-deeb, Ibrahim M., Li, Gen, Keller, Nadia, Brouwer, Stephan, Harbison-Price, Nichaela, Cork, Amanda J., Bauer, Michelle J., Alquethamy, Saleh F., Beatson, Scott A., Roberts, Jason A., Paterson, David L., McEwan, Alastair G., Blaskovich, Mark A. T., Schembri, Mark A., McDevitt, Christopher A., von Itzstein, Mark and Walker, Mark J. (2022). Rescuing Tetracycline Class Antibiotics for the Treatment of Multidrug-Resistant Acinetobacter baumannii Pulmonary Infection. mBio, 13 (1) e03517, e0351721. doi: 10.1128/mbio.03517-21

  • König, Gerhard, Sokkar, Pandian, Pryk, Niclas, Heinrich, Sascha, Möller, David, Cimicata, Giuseppe, Matzov, Donna, Dietze, Pascal, Thiel, Walter, Bashan, Anat, Elisabeth Bandow, Julia, Zuegg, Johannes, Yonath, Ada, Schulz, Frank and Sanchez-Garcia, Elsa (2021). Rational prioritization strategy allows the design of macrolide derivatives that overcome antibiotic resistance. Proceedings of the National Academy of Sciences of the United States of America, 118 (46) e2113632118. doi: 10.1073/pnas.2113632118

  • Demchenko, Sergii, Lesyk, Roman, Yadlovskyi, Oleh, Zuegg, Johannes, Elliott, Alysha G., Drapak, Iryna, Fedchenkova, Yuliia, Suvorova, Zinaida and Demchenko, Anatolii (2021). Synthesis, antibacterial and antifungal activity of new 3-Aryl-5H-pyrrolo[1,2-a]imidazole and 5H-Imidazo[1,2-a]azepine quaternary salts. Molecules, 26 (14) 4253, 1-13. doi: 10.3390/molecules26144253

  • Semenov, Victor V., Raihstat, Mikhail M., Konyushkin, Leonid D., Semenov, Roman V., Blaskovich, Mark A. T., Zuegg, Johannes, Elliott, Alysha G., Hansford, Karl A. and Cooper, Matthew A. (2021). Antimicrobial screening of a historical collection of over 140 000 small molecules. Mendeleev Communications, 31 (4), 484-487. doi: 10.1016/j.mencom.2021.07.015

  • Frei, Angelo, King, A. Paden, Lowe, Gabrielle J., Cain, Amy K., Short, Francesca L., Dinh, Hue, Elliott, Alysha G., Zuegg, Johannes, Wilson, Justin J. and Blaskovich, Mark A. T. (2021). Cover feature: nontoxic cobalt(III) schiff base complexes with broad‐spectrum antifungal activity (Chem. Eur. J. 6/2021). Chemistry – A European Journal, 27 (6), 1861-1861. doi: 10.1002/chem.202004912

  • Frei, Angelo, King, A. Paden, Lowe, Gabrielle J., Cain, Amy K., Short, Francesca L., Dinh, Hue, Elliott, Alysha G., Zuegg, Johannes, Wilson, Justin J. and Blaskovich, Mark A. T. (2021). Nontoxic cobalt(III) schiff base complexes with broad‐spectrum antifungal activity. Chemistry – A European Journal, 27 (6), 2021-2029. doi: 10.1002/chem.202003545

  • Blaskovich, Mark A. T., Kavanagh, Angela M., Elliott, Alysha G., Zhang, Bing, Ramu, Soumya, Amado, Maite, Lowe, Gabrielle J., Hinton, Alexandra O., Pham, Do Minh Thu, Zuegg, Johannes, Beare, Neil, Quach, Diana, Sharp, Marc D., Pogliano, Joe, Rogers, Ashleigh P., Lyras, Dena, Tan, Lendl, West, Nicholas P., Crawford, David W., Peterson, Marnie L., Callahan, Matthew and Thurn, Michael (2021). The antimicrobial potential of cannabidiol. Communications Biology, 4 (1) 7, 1-18. doi: 10.1038/s42003-020-01530-y

  • Frei, Angelo, Ramu, Soumya, Lowe, Gabrielle J., Dinh, Hue, Semenec, Lucie, Elliott, Alysha G., Zuegg, Johannes, Deckers, Anke, Jung, Nicole, Bräse, Stefan, Cain, Amy K. and Blaskovich, Mark A. T. (2021). Platinum cyclooctadiene complexes with activity against gram-positive bacteria. ChemMedChem, 16 (20) cmdc.202100157, 1-8. doi: 10.1002/cmdc.202100157

  • Fuller, Amelia A., Dounay, Amy B., Schirch, Douglas, Rivera, Daniel G., Hansford, Karl A., Elliott, Alysha G., Zuegg, Johannes, Cooper, Matthew A., Blaskovich, Mark A. T., Hitchens, Jacob R., Burris-Hiday, Sarah, Tenorio, Kristiana, Mendez, Yanira, Samaritoni, J. Geno, O’Donnell, Martin J. and Scott, William L. (2020). Multi-institution research and education collaboration identifies new antimicrobial compounds. ACS Chemical Biology, 15 (12), 3187-3196. doi: 10.1021/acschembio.0c00732

  • Pamarthi, Rambabu, Kumar, Ram, Sankara, Chennikkayala Siva, Lowe, Gabrielle J., Zuegg, Johannes, Singh, Sudheer Kumar and Ganesh, Madhu (2020). α-Iodonitroalkenes as potential antifungal and antitubercular agents. ChemistrySelect, 5 (39), 12272-12277. doi: 10.1002/slct.202003251

  • Demchenko, Sergii, Lesyk, Roman, Zuegg, Johannes, Elliott, Alysha G., Fedchenkova, Yuliia, Suvorova, Zinaida and Demchenko, Anatolii (2020). Synthesis, antibacterial and antifungal activity of new 3-biphenyl-3H-Imidazo[1,2-a]azepin-1-ium bromides. European Journal of Medicinal Chemistry, 201 112477, 112477. doi: 10.1016/j.ejmech.2020.112477

  • Elliott, Alysha G., Huang, Johnny X., Neve, Søren, Zuegg, Johannes, Edwards, Ingrid A., Cain, Amy K., Boinett, Christine J., Barquist, Lars, Lundberg, Carina Vingsbo, Steen, Jason, Butler, Mark S., Mobli, Mehdi, Porter, Kaela M., Blaskovich, Mark A. T., Lociuro, Sergio, Strandh, Magnus and Cooper, Matthew A. (2020). An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria. Nature Communications, 11 (1) 3184, 3184. doi: 10.1038/s41467-020-16950-x

  • Zuegg, Johannes, Hansford, Karl A., Elliott, Alysha G., Cooper, Matthew A. and Blaskovich, Mark A. T. (2020). How to stimulate and facilitate early stage antibiotic discovery. ACS Infectious Diseases, 6 (6), 1302-1304. doi: 10.1021/acsinfecdis.0c00163

  • Frei, Angelo, Zuegg, Johannes, Elliott, Alysha G., Baker, Murray, Braese, Stefan, Brown, Christopher, Chen, Feng, Dowson, Christopher G., Dujardin, Gilles, Jung, Nicole, King, A. Paden, Mansour, Ahmed M., Massi, Massimiliano, Moat, John, Mohamed, Heba A., Renfrew, Anna K., Rutledge, Peter J., Sadler, Peter J., Todd, Matthew H., Willans, Charlotte E., Wilson, Justin J., Cooper, Matthew A. and Blaskovich, Mark A. T. (2020). Correction: Metal complexes as a promising source for new antibiotics (vol 11, pg 2627, 2020). Chemical Science, 11 (17), 4531-4531. doi: 10.1039/d0sc90075c

  • Rineh, Ardeshir, Soren, Odel, McEwan, Timothy, Ravikumar, Vikashini, Poh, Wee Han, Azamifar, Fereshteh, Naimi-Jamal, M. Reza, Cheung, Chen-Yi, Elliott, Alysha G., Zuegg, Johannes, Blaskovich, Mark A. T., Cooper, Matthew A., Dolange, Victoria, Christodoulides, Myron, Cook, Gregory M., Rice, Scott A., Faust, Saul N., Webb, Jeremy S. and Kelso, Michael J. (2020). Discovery of cephalosporin-3′-diazeniumdiolates that show dual antibacterial and antibiofilm effects against Pseudomonas aeruginosa clinical cystic fibrosis isolates and efficacy in a murine respiratory infection model. ACS Infectious Diseases, 6 (6) acsinfecdis.0c00070, 1460-1479. doi: 10.1021/acsinfecdis.0c00070

  • Frei, Angelo, Zuegg, Johannes, Elliott, Alysha G., Baker, Murray V., Braese, Stefan, Brown, Christopher, Chen, Feng, Dowson, Christopher Gerard, Dujardin, Gilles, Jung, Nicole, King, A. Paden, Mansour, Ahmed Moustafa, Massi, Massimiliano, Moat, John, Mohamed, Heba A., Renfrew, Anna, Rutledge, Peter, Sadler, Peter J., Todd, Matthew Houghton, Willans, Charlotte E., Wilson, Justin Jeff, Cooper, Matthew Allister and Blaskovich, Mark (2020). Metal complexes as a promising source for new antibiotics. Chemical Science, 11 (10), 2627-2639. doi: 10.1039/c9sc06460e

  • Nazir, Yasir, Saeed, Aamer, Rafiq, Muhammad, Afzal, Samina, Ali, Anser, Latif, Muhammad, Zuegg, Johannes, Hussein, Waleed M., Fercher, Christian, Barnard, Ross T., Cooper, Matthew A., Blaskovich, Mark A.T., Ashraf, Zaman and Ziora, Zyta M. (2020). Hydroxyl substituted benzoic acid/cinnamic acid derivatives: tyrosinase inhibitory kinetics, anti-melanogenic activity and molecular docking studies. Bioorganic and Medicinal Chemistry Letters, 30 (1) 126722, 1-5. doi: 10.1016/j.bmcl.2019.126722

  • Overman, Jeroen, Fontaine, Frank, Wylie-Sears, Jill, Moustaqil, Mehdi, Huang, Lan, Meurer, Marie, Chiang, Ivy Kim, Lesieur, Emmanuelle, Patel, Jatin, Zuegg, Johannes, Pasquier, Eddy, Sierecki, Emma, Gambin, Yann, Hamdan, Mohamed, Khosrotehrani, Kiarash, Andelfinger, Gregor, Bischoff, Joyce and Francois, Mathias (2019). R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma. eLife, 8 e43026. doi: 10.7554/elife.43026

  • Rao, Madhuri P., Gunaga, Shubha S., Zuegg, Johannes, Pamarthi, Rambabu and Ganesh, Madhu (2019). Highly regio- and diastereoselective [3 + 2]-cycloadditions involving indolediones and α,β-disubstituted nitroethylenes. Organic and Biomolecular Chemistry, 17 (42), 9390-9402. doi: 10.1039/c9ob01429b

  • Fontaine, Frank R., Goodall, Stephen, Prokop, Jeremy W., Howard, Christopher B., Moustaqil, Mehdi, Kumble, Sumukh, Rasicci, Daniel T., Osborne, Geoffrey W., Gambin, Yann, Sierecki, Emma, Jones, Martina L., Zuegg, Johannes, Mahler, Stephen and Francois, Mathias (2018). Functional domain analysis of SOX18 transcription factor using a single-chain variable fragment-based approach. mAbs, 10 (4), 1-11. doi: 10.1080/19420862.2018.1451288

  • Blaskovich, Mark A T, Hansford, Karl A., Gong, Yujing, Butler, Mark S., Muldoon, Craig, Huang, Johnny X., Ramu, Soumya, Silva, Alberto B., Cheng, Mu, Kavanagh, Angela M., Ziora, Zyta, Premraj, Rajaratnam, Lindahl, Fredrik, Bradford, Tanya A., Lee, June C., Karoli, Tomislav, Pelingon, Ruby, Edwards, David J., Amado, Maite, Elliott, Alysha G, Phetsang, Wanida, Daud, Noor Huda, Deecke, Johan E, Sidjabat, Hanna E, Ramaologa, Sefetogi, Zuegg, Johannes, Betley, Jason R, Beevers, Andrew P G, Smith, Richard A G ... Cooper, Matthew A. (2018). Protein-inspired antibiotics active against vancomycin- and daptomycin-resistant bacteria. Nature Communications, 9 (1) 02123, 22. doi: 10.1038/s41467-017-02123-w

  • Scott, Fraser J., Nichol, Ryan J. O., Khalaf, Abedawn I., Giordani, Federica, Gillingwater, Kirsten, Ramu, Soumya, Elliott, Alysha, Zuegg, Johannes, Duffy, Paula, Rosslee, Michael-Jon, Hlaka, Lerato, Kumar, Santosh, Ozturk, Mumin, Brombacher, Frank, Barrett, Michael, Guler, Reto and Suckling, Colin J. (2017). An evaluation of Minor Groove Binders as anti-fungal and anti-mycobacterial therapeutics. European Journal of Medicinal Chemistry, 136, 561-572. doi: 10.1016/j.ejmech.2017.05.039

  • Desselle, Mathilde R., Neale, Ruth, Hansford, Karl A., Zuegg, Johannes, Elliott, Alysha G., Cooper, Matthew A. and Blaskovich, Mark A. T. (2017). Institutional profile: Community for Open Antimicrobial Drug Discovery - crowdsourcing new antibiotics and antifungals. Future Science OA, 3 (2) FSO171, FSO171. doi: 10.4155/fsoa-2016-0093

  • Fontaine, Frank, Overman, Jeroen, Moustaqil, Mehdi, Mamidyala, Sreeman, Salim, Angela, Narasimhan, Kamesh, Prokoph, Nina, Robertson, Avril A. B., Lua, Linda, Alexandrov, Kirill, Koopman, Peter, Capon, Robert J., Sierecki, Emma, Gambin, Yann, Jauch, Ralf, Cooper, Matthew A., Zuegg, Johannes and Francois, Mathias (2017). Small-molecule inhibitors of the SOX18 transcription factor. Chemistry Chemical Biology, 24 (3), 346-359. doi: 10.1016/j.chembiol.2017.01.003

  • Overman, Jeroen, Fontaine, Frank, Moustaqil, Mehdi, Mittal, Deepak, Sierecki, Emma, Sacilotto, Natalia, Zuegg, Johannes, Robertson, Avril A. B., Holmes, Kelly, Salim, Angela A., Mamidyala, Sreeman, Butler, Mark S., Robinson, Ashley S., Lesieur, Emmanuelle, Johnston, Wayne, Alexandrov, Kirill, Black, Brian L., Hogan, Benjamin M., De Val, Sarah, Capon, Robert J., Carroll, Jason S., Bailey, Timothy L., Koopman, Peter, Jauch, Ralf, Smyth, Mark J., Cooper, Matthew A., Gambin, Yann and Francois, Mathias (2017). Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. eLife, 6 e21221. doi: 10.7554/eLife.21221

  • Edwards, Ingrid A., Elliott, Alysha G., Kavanagh, Angela M., Zuegg, Johannes, Blaskovich, Mark A. T. and Cooper, Matthew A. (2016). Contribution of amphipathicity and hydrophobicity to the antimicrobial activity and cytotoxicity of β‑hairpin peptides. ACS Infectious Diseases, 2 (6), 442-450. doi: 10.1021/acsinfecdis.6b00045

  • Mesleh, Michael F., Rajaratnam, Premraj, Conrad, Mary, Chandrasekaran, Vasu, Liu, Christopher M., Pandya, Bhaumik A., Hwang, You Seok, Rye, Peter T., Muldoon, Craig, Becker, Bernd, Zuegg, Johannes, Meutermans, Wim and Moy, Terence I. (2016). Targeting bacterial cell wall peptidoglycan synthesis by inhibition of glycosyltransferase activity. Chemical Biology and Drug Design, 87 (2), 190-199. doi: 10.1111/cbdd.12662

  • Jarrad, Angie M., Karoli, Tomislav, Anjan, Debnath, Tay, Chin Yen, Huang, Johnny X., Kaeslin, Geraldine, Elliott, Alysha G., Miyamoto, Yukiko, Ramu, Soumya, Kavanagh, Angela M., Zuegg, Johannes, Eckmann, Lars, Blaskovich, Mark A. and Cooper, Matthew A. (2015). Metronidazole-triazole conjugates: activity against Clostridium difficile and parasites. European Journal of Medicinal Chemistry, 101 7946, 96-102. doi: 10.1016/j.ejmech.2015.06.019

  • Zuegg, Johannes, Muldoon, Craig, Adamson, George, McKeveney, Declan, Le Thanh, Giang, Premraj, Rajaratnam, Becker, Bernd, Cheng, Mu, Elliott, Alysha G., Huang, Johnny X., Butler, Mark S., Bajaj, Megha, Seifert, Joachim, Singh, Latika, Galley, Nicola F., Roper, David I., Lloyd, Adrian J., Dowson, Christopher G., Cheng, Ting-Jen, Cheng, Wei-Chieh, Demon, Dieter, Meyer, Evelyne, Meutermans, Wim and Cooper, Matthew A. (2015). Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity. Nature Communications, 6 (1) 7719, 1-11. doi: 10.1038/ncomms8719

  • Blaskovich, Mark A. T., Zuegg, Johannes, Elliott, Alysha G. and Cooper, Matthew (2015). Helping chemists discover new antibiotics. ACS Infectious Diseases, 1 (7), 285-287. doi: 10.1021/acsinfecdis.5b00044

  • Bajaj, Megha, Mamidyala, Sreeman K., Zuegg, Johannes, Begg, Stephanie L., Ween, Miranda P., Luo, Zhenyao, Huang, Johnny Xiao, McEwan, Alastair G., Kobe, Bostjan, Paton, James C., McDevitt, Christopher A. and Cooper, Matthew A. (2015). Discovery of novel pneumococcal surface antigen A (PsaA) inhibitors using a fragment-based drug design approach. ACS Chemical Biology, 10 (6), 1511-1520. doi: 10.1021/cb501032x

  • Zuegg, Johannes (2015). Neue Strukturen für Antibiotika gesucht. Nachrichten aus der Chemie, 63 (11), 1101-1103. doi: 10.1002/nadc.201590371

  • Phetsang, Wanida, Blaskovich, Mark A. T., Butler, Mark S., Huang, Johnny Xiao, Zuegg, Johannes, Mamidyala, Sreeman K., Ramu, Soumya, Kavanagh, Angela M. and Cooper, Matthew A. (2014). An azido-oxazolidinone antibiotic for live bacterial cell imaging and generation of antibiotic variants. Bioorganic and Medicinal Chemistry, 22 (16), 4490-4498. doi: 10.1016/j.bmc.2014.05.054

  • Couñago, Rafael M., Ween, Miranda P., Begg, Stephanie L., Bajaj, Megha, Zuegg, Johannes, O'Mara, Megan L., Cooper, Matthew A., McEwan, Alastair G., Paton, James C., Kobe, Bostjan and McDevitt, Christopher A. (2014). Imperfect coordination chemistry facilitates metal ion release in the Psa permease. Nature Chemical Biology, 10 (1), 35-41. doi: 10.1038/nCHeMBIO.1382

  • Jia, ZhiGuang, O'Mara, Megan L., Zuegg, Johannes, Cooper, Matthew A. and Mark, Alan E. (2013). Vancomycin: ligand recognition, dimerization and super-complex formation. FEBS Journal, 280 (5), 1294-1307. doi: 10.1111/febs.12121

  • Jia, Z. G., O'Mara, M. L., Zuegg, J., Matthew Cooper and Mark, Alan (2013). Erratum: The effect of environment on the recognition and binding of vancomycin to native and resistant forms of lipid II (Biophysical Journal (2011) 101 (2684-2692)). Biophysical Journal, 104 (2), 516-516. doi: 10.1016/j.bpj.2012.12.031

  • Novoa, Alexandre, Van Dorpe, Sylvia, Wynendaele, Evelien, Spetea, Mariana, Bracke, Nathalie, Stalmans, Sofie, Betti, Cecilia, Chung, Nga N., Lemieux, Carole, Zuegg, Johannes, Cooper, Matthew A., Tourwe, Dirk, De Spiegeleer, Bart, Schiller, Peter W. and Ballet, Steven (2012). Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: effect on opioid activity and biodistribution. Journal of Medicinal Chemistry, 55 (22), 9549-9561. doi: 10.1021/jm3008079

  • Karoli, Tomislav, Becker, Bernd, Zuegg, Johannes, Moellmann, Ute, Ramu, Soumya, Huang, Johnny X. and Cooper, Matthew A. (2012). Identification of antitubercular benzothiazinone compounds by ligand-based design. Journal of Medicinal Chemistry, 55 (17), 7940-7944. doi: 10.1021/jm3008882

  • Zuegg, Johannes and Cooper, Matthew A. (2012). Drug-likeness and increased hydrophobicity of commercially available compound libraries for drug screening. Current Topics in Medicinal Chemistry, 12 (14), 1500-1513. doi: 10.2174/156802612802652466

  • Karoli, Tomislav, Mamidyala, Sreeman K., Zuegg, Johannes, Fry, Scott R., Tee, Ernest H. L., Bradford, Tanya A., Madala, Praveen K., Huang, Johnny X., Ramu, Soumya, Butler, Mark S. and Cooper, Matthew A. (2012). Structure aided design of chimeric antibiotics. Bioorganic & Medicinal Chemistry Letters, 22 (7), 2428-2433. doi: 10.1016/j.bmcl.2012.02.019

  • Jia, ZhiGuang, O'Mara, Megan L., Zuegg, Johannes, Cooper, Matthew A. and Mark, Alan E. (2011). The effect of environment on the recognition and binding of vancomycin to native and resistant forms of lipid II. Biophysical Journal, 101 (11), 2684-2692. doi: 10.1016/j.bpj.2011.10.047

  • Abbenante, Giovanni, Becker, Bernd, Blanc, Sebastien, Clark, Chris, Condie, Glenn, Fraser, Graeme, Grathwohl, Matthias, Halliday, Judy, Henderson, Senka, Lam, Ann, Liu, Ligong, Mann, Maretta, Muldoon, Craig, Pearson, Andrew, Premraj, Rajaratnam, Ramsdale, Tracie, Rossetti, Tony, Schafer, Karl, Le Thanh, Giang, Tometzki, Gerald, Vari, Frank, Verquin, Geraldine, Waanders, Jennifer, West, Michael, Wimmer, Norbert, Yau, Annika, Zuegg, Johannes and Meutermans, Wim (2010). Biological diversity from a structurally diverse library: Systematically scanning conformational space using a pyranose scaffold. Journal of Medicinal Chemistry, 53 (15), 5576-5586. doi: 10.1021/jm1002777

  • Thanh, Giang Le, Abbenante, Giovanni, Adamson, George, Becker, Bernd, Clark, Chris, Condie, Glenn, Falzun, Tania, Grathwohl, Matthias, Gupta, Praveer, Hanson, Michael, Huynh, Ngoc, Katavic, Peter, Kuipers, Krystle, Lam, Ann, Liu, Ligong, Mann, Maretta, Mason, Jeff, McKeveney, Declan, Muldoon, Craig, Pearson, Andrew, Rajaratnam, Premraj, Ryan, Sarah, Tometzki, Gerry, Verquin, Geraldine, Waanders, Jennifer, West, Michael, Wilcox, Neil, Wimmer, Norbert, Yau, Annika ... Meutermans, Wim (2010). A versatile synthetic approach toward diversity libraries using monosaccharide scaffolds. Journal of Organic Chemistry, 75 (1), 197-203. doi: 10.1021/jo9021919

  • Zuegg, Johannes and Meutermans, Wim (2007). Crystal structures of the PBP2 glycosyltransferase domain: For antibacterial drug design new opportunities. Chemmedchem, 2 (10), 1403-1404. doi: 10.1002/cmdc.200700114

  • Pham T.D. and Zuegg J. (2004). A probabilistic measure for alignment-free sequence comparison. Bioinformatics, 20 (18), 3455-3461. doi: 10.1093/bioinformatics/bth426

  • Zuegg, J, Bliznyuk, AA and Gready, JE (2003). Comparison of electrostatic potential around proteins calculated from Amber and AM1 charges: application to mutants of prion protein. Molecular Physics, 101 (15), 2437-2450. doi: 10.1080/00268970310001592737

  • Le, GT, Abbenante, G, Becker, B, Grathwohl, M, Halliday, J, Tometzki, G, Zuegg, J and Meutermans, W (2003). Molecular diversity through sugar scaffolds. Drug Discovery Today, 8 (15), 701-709. doi: 10.1016/S1359-6446(03)02751-X

  • Zuegg, J., Webb, D. C., Foster, P. S. and Casarotto, M. G. (2001). Structural model of human IL-13 defines the spatial interactions with the IL-13Rα/IL-4Rα receptor. Immunology and Cell Biology, 79 (4), 332-339. doi: 10.1046/j.1440-1711.2001.01035.x

  • Hulett M.D., Hornby J.R., Ohms S.J., Zuegg J., Freeman C., Gready J.E. and Parish C.R. (2000). Identification of active-site residues of the pro-metastatic endoglycosidase heparanase. Biochemistry, 39 (51), 15659-15667. doi: 10.1021/bi002080p

  • Zuegg, J and Gready, JE (2000). Molecular dynamics simulation of human prion protein including both N-linked oligosaccharides and the GPI anchor. Glycobiology, 10 (10), 959-974. doi: 10.1093/glycob/10.10.959

  • Zuegg J. and Gready J.E. (1999). Molecular dynamics simulations of human prion protein: Importance of correct treatment of electrostatic interactions. Biochemistry, 38 (42), 13862-13876. doi: 10.1021/bi991469d

  • Zuegg, J, Gruber, K, Gugganig, M, Wagner, UG and Kratky, C (1999). Three-dimensional structures of enzyme-substrate complexes of the hydroxynitrile lyase from Hevea brasiliensis. Protein Science, 8 (10), 1990-2000. doi: 10.1110/ps.8.10.1990

  • Weber H.K., Zuegg J., Faber K. and Pleiss J. (1997). Molecular reasons for lipase-sensitivity against acetaldehyde. Journal of Molecular Catalysis - B Enzymatic, 3 (1-4), 131-138. doi: 10.1016/S1381-1177(96)00045-8

  • Zuegg J., Honig H., Schrag J.D. and Cygler M. (1997). Selectivity of lipases: Conformational analysis of suggested intermediates in ester hydrolysis of chiral primary and secondary alcohols. Journal of Molecular Catalysis - B Enzymatic, 3 (1-4), 83-98. doi: 10.1016/S1381-1177(96)00060-4

  • Petersen, EI, Zuegg, J, Ribbons, DW and Schwab, H (1996). Molecular cloning and homology modeling of protocatechuate 3,4-dioxygenase from Pseudomonas marginata. Microbiological Research, 151 (4), 359-370. doi: 10.1016/S0944-5013(96)80004-8

  • Faber, K, Griengl, H, Honig, H and Zuegg, J (1994). On the Prediction of the Enantioselectivity of Candida-Rugosa Lipase by Comparative Molecular-Field Analysis. Biocatalysis, 9 (1-4), 227-239. doi: 10.3109/10242429408992122

  • Martl, MG, Zuegg, J and Hummel, K (1991). Improved Computer-Simulation of Metathesis Reactions. Journal of Molecular Catalysis, 65 (1-2), 127-138. doi: 10.1016/0304-5102(91)85089-K

Conference Publication

Other Outputs

  • Francois, Mathias, Zuegg, Johannes, Overman, Jeroen, Mamidyala, Sreeman Kumar, Salim, Angela Aguslyarti, Fontaine, Frank Roger, Cooper, Matthew Allister, Capon, Robert John and Robertson, Avril Alexis Barbara (2017). Inhibitors of SOX 18 protein activity for treating angiogenesis- and/or lymphangiogenesis. WO2018112545.

  • Tometzki, Gerald B., Meutermans, Wim, Becker, Bernd, Zuegg, Johannes, Premraj, Rajaratnam, Muldoon, Craig, Mckeveney, Declan and Condie, Glenn (2008). Selective Inhibitors. US 20080009418.

  • Meutermans, Wim, Mckeveney, Declan, Zuegg, Johannes, Premraj, Rajaratnam, Muldoon, Craig and Le Thanh, Giang (2007). Monosaccharide compounds as antibacterial agents and their preparation and use in the treatment of diseases.

  • Becker, Bernd, Condie, Glenn, Christopher, McKeveney, Declan, Meutermans, Wim, Muldoon, Craig, Premraj, Rajaratnam and Zuegg, Johannes (2006). Selective inhibitors. WO/2006/037159; PCT/AU2005/001510.

  • Becker, Bernd, Condie, Glenn, Halliday, Judy, McKeveney, Declan, Meutermans, Wim, Muldoon, Craig, Premraj, Rajaratnam, Ramsdale, Tracie Elizabeth, Tometzki, Gerald and Zuegg, Johannes (2005). Biologically active compounds with with anti-angiogenic properties. WO/2005/097142; PCT/AU2005/000506.

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

    Other advisors:

Completed Supervision