Dr Ivar Noordstra

Research Fellow

Institute for Molecular Bioscience

Overview

Qualifications

  • Doctor of Philosophy, Utrecht University

Publications

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Supervision

View all Supervision

Publications

Book Chapter

Journal Article

  • Campàs, Otger, Noordstra, Ivar and Yap, Alpha S. (2023). Adherens junctions as molecular regulators of emergent tissue mechanics. Nature Reviews Molecular Cell Biology. doi: 10.1038/s41580-023-00688-7

  • Schimmel, Lilian and Noordstra, Ivar (2023). Epithelial cell spreading assay on E-cadherin-coated glass or PDMS substrates for microscopy-based analysis of cadherin adhesions. STAR Protocols, 4 (4) 102626, 102626. doi: 10.1016/j.xpro.2023.102626

  • Noordstra, Ivar, Hermoso, Mario Díez, Schimmel, Lilian, Bonfim-Melo, Alexis, Currin-Ross, Denni, Duong, Cao Nguyen, Kalappurakkal, Joseph Mathew, Morris, Richard G., Vestweber, Dietmar, Mayor, Satyajit, Gordon, Emma, Roca-Cusachs, Pere and Yap, Alpha S. (2023). An E-cadherin-actin clutch translates the mechanical force of cortical flow for cell-cell contact to inhibit epithelial cell locomotion. Developmental Cell, 58 (18), 1748-1763.e6. doi: 10.1016/j.devcel.2023.06.011

  • Noordstra, Ivar, Morris, Richard G. and Yap, Alpha S. (2023). Cadherins and the cortex: A matter of time?. Current Opinion in Cell Biology, 80 102154, 102154. doi: 10.1016/j.ceb.2023.102154

  • Noordstra, Ivar, van den Berg, Cyntha M., Boot, Fransje W J, Katrukha, Eugene A., Yu, Ka Lou, Tas, Roderick P., Portegies, Sybren, Viergever, Bastiaan J., de Graaff, Esther, Hoogenraad, Casper C., de Koning, Eelco J P, Carlotti, Françoise, Kapitein, Lukas C. and Akhmanova, Anna (2022). Organization and dynamics of the cortical complexes controlling insulin secretion in β-cells. Journal of cell science, 135 (3) jcs259430. doi: 10.1242/jcs.259430

  • Bonfim-Melo, Alexis, Noordstra, Ivar, Gupta, Shafali, Chan, Amy H., Jones, Mathew J.K., Schroder, Kate and Yap, Alpha S. (2022). Rapid lamellipodial responses by neighbor cells drive epithelial sealing in response to pyroptotic cell death. Cell Reports, 38 (5) 110316, 110316. doi: 10.1016/j.celrep.2022.110316

  • Duszyc, Kinga, Noordstra, Ivar, Yap, Alpha S and Gomez, Guillermo A (2021). Live imaging of apoptotic extrusion and quantification of apical extrusion in epithelial cells. Bio-protocol, 11 (22) e4232, e4232. doi: 10.21769/BioProtoc.4232

  • Arts, Janine J. G., Mahlandt, Eike K., Grönloh, Max, Schimmel, Lilian, Noordstra, Ivar, Gordon, Emma, van Steen, Abraham C.I., Tol, Simon, Walzog, Barbara, van Rijssel, Jos, Nolte, Martijn A., Postma, Marten, Khuon, Satya, Heddleston, John M., Wait, Eric, Chew, Teng Leong, Winter, Mark, Montanez, Eloi, Goedhart, Joachim and van Buul, Jaap D. (2021). Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration. eLife, 10 e66074. doi: 10.7554/elife.66074

  • Gupta, Shafali, Duszyc, Kinga, Verma, Suzie, Budnar, Srikanth, Liang, Xuan, Gomez, Guillermo A., Marcq, Philippe, Noordstra, Ivar and Yap, Alpha S. (2021). Enhanced RhoA signaling stabilizes E-cadherin in migrating epithelial monolayers. Journal of Cell Science, 134 (17) jcs258767, 1-13. doi: 10.1242/jcs.258767

  • Noordstra, Ivar and Yap, Alpha S. (2021). For whom the cell tolls. Developmental Cell, 56 (11), 1555-1557. doi: 10.1016/j.devcel.2021.05.013

  • Teo, Jessica L., Gomez, Guillermo A., Weeratunga, Saroja, Davies, Elizabeth M., Noordstra, Ivar, Budnar, Srikanth, Katsuno-Kambe, Hiroko, McGrath, Meagan J., Verma, Suzie, Tomatis, Vanesa, Acharya, Bipul R., Balasubramaniam, Lakshmi, Templin, Rachel M., McMahon, Kerrie-Ann, Lee, Yoke Seng, Ju, Robert J., Stebhens, Samantha J., Ladoux, Benoit, Mitchell, Christina A., Collins, Brett M., Parton, Robert G. and Yap, Alpha S. (2020). Caveolae control contractile tension for epithelia to eliminate tumor cells. Developmental Cell, 54 (1), 75-91.e7. doi: 10.1016/j.devcel.2020.05.002

  • Gerlach, Jan P., Jordens, Ingrid, Tauriello, Daniele V. F., Land-Kuper, Ineke van 't, Bugter, Jeroen M., Noordstra, Ivar, van der Kooij, Johanneke, Low, Teck Y., Pimentel-Muiños, Felipe X., Xanthakis, Despina, Fenderico, Nicola, Rabouille, Catherine, Heck, Albert J. R., Egan, David A. and Maurice, Madelon M. (2018). TMEM59 potentiates Wnt signaling by promoting signalosome formation. Proceedings of the National Academy of Sciences of the United States of America, 115 (17), E3996-E4005. doi: 10.1073/pnas.1721321115

  • Akhmanova, Anna and Noordstra, Ivar (2017). Linking cortical microtubule attachment and exocytosis. F1000Research, 6 469, 469. doi: 10.12688/f1000research.10729.1

  • Bouchet, Benjamin P., Noordstra, Ivar, van Amersfoort, Miranda, Katrukha, Eugene A., Ammon, York-Christoph, ter Hoeve, Natalie D., Hodgson, Louis, Dogterom, Marileen, Derksen, Patrick W. B. and Akhmanova, Anna (2016). Mesenchymal cell invasion requires cooperative regulation of persistent microtubule growth by SLAIN2 and CLASP1. Developmental Cell, 39 (6), 708-723. doi: 10.1016/j.devcel.2016.11.009

  • Wu, Jingchao, de Heus, Cecilia, Liu, Qingyang, Bouchet, Benjamin P., Noordstra, Ivar, Jiang, Kai, Hua, Shasha, Martin, Maud, Yang, Chao, Grigoriev, Ilya, Katrukha, Eugene A., Altelaar, A. F. Maarten, Hoogenraad, Casper C., Qi, Robert Z., Klumperman, Judith and Akhmanova, Anna (2016). Molecular pathway of microtubule organization at the golgi apparatus. Developmental Cell, 39 (1), 44-60. doi: 10.1016/j.devcel.2016.08.009

  • Noordstra, Ivar, Liu, Qingyang, Nijenhuis, Wilco, Hua, Shasha, Jiang, Kai, Baars, Matthijs, Remmelzwaal, Sanne, Martin, Maud, Kapitein, Lukas C. and Akhmanova, Anna (2016). Control of apico-basal epithelial polarity by the microtubule minus-end-binding protein CAMSAP3 and spectraplakin ACF7. Journal of Cell Science, 129 (22), 4278-4288. doi: 10.1242/jcs.194878

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

    Other advisors:

Completed Supervision