Rebecca completed her PhD at the Illawarra Health and Medical Research Institute at the University of Wollongong in June 2018. Her PhD research investigated the role of the heat shock response and inflammation in neurodegenerative diseases with a focus on motor neuron disease (MND). During her PhD, Rebecca undertook an Endeavour Research Fellowship to conduct research at the Institute of Neurology, University College London under the supervision of Prof Linda Greensmith. She has since been recruited to the Neurodegeneration Pathobiology Lab at the Queensland Brain Institute by Dr Adam Walker as a Postdoctoral Research Fellow. Rebecca is a motivated and passionate MND researcher whose main objective is to find new therapeutics to treat or cure people living with MND.
Journal Article: A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration
San Gil, Rebecca, Pascovici, Dana, Venturato, Juliana, Brown-Wright, Heledd, Mehta, Prachi, Madrid San Martin, Lidia, Wu, Jemma, Luan, Wei, Chui, Yi Kit, Bademosi, Adekunle T., Swaminathan, Shilpa, Naidoo, Serey, Berning, Britt A., Wright, Amanda L., Keating, Sean S., Curtis, Maurice A., Faull, Richard L. M., Lee, John D., Ngo, Shyuan T., Lee, Albert, Morsch, Marco, Chung, Roger S., Scotter, Emma, Lisowski, Leszek, Mirzaei, Mehdi and Walker, Adam K. (2024). A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration. Nature Communications, 15 (1) 1508, 1508. doi: 10.1038/s41467-024-45646-9
Journal Article: UndERACting ion channels in neurodegeneration
Jacobs, Matisse T., San Gil, Rebecca and Walker, Adam K. (2023). UndERACting ion channels in neurodegeneration. Trends in Neurosciences, 47 (2), 87-89. doi: 10.1016/j.tins.2023.11.002
Journal Article: Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD
Luan, Wei, Wright, Amanda L., Brown-Wright, Heledd, Le, Sheng, San Gil, Rebecca, Madrid San Martin, Lidia, Ling, Karen, Jafar-Nejad, Paymaan, Rigo, Frank and Walker, Adam K. (2023). Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD. Molecular Psychiatry, 28 (6), 2445-2461. doi: 10.1038/s41380-023-02036-9
Oligodendrocytes and TDP-43 pathology in MND
(2024–2027) Cure for MND Foundation - Discovery Research Grants
Synaptic mechanisms of non-motor dysfunction in MND
(2024–2025) Motor Neurone Disease Research Institute of Australia Inc Innovator Grant
Defining the involvement of ubiquilin-2 in MND
(2021–2022) Motor Neurone Disease Research Institute of Australia Inc
The Role of NFI Genes in Maintaining Astrocyte Differentiation
Doctor Philosophy
TDP-43 and the autophagy-lysosome proteostasis system in the pathogenesis and treatment of ALS/FTD
Doctor Philosophy
San Gil, Rebecca, Pascovici, Dana, Venturato, Juliana, Brown-Wright, Heledd, Mehta, Prachi, Madrid San Martin, Lidia, Wu, Jemma, Luan, Wei, Chui, Yi Kit, Bademosi, Adekunle T., Swaminathan, Shilpa, Naidoo, Serey, Berning, Britt A., Wright, Amanda L., Keating, Sean S., Curtis, Maurice A., Faull, Richard L. M., Lee, John D., Ngo, Shyuan T., Lee, Albert, Morsch, Marco, Chung, Roger S., Scotter, Emma, Lisowski, Leszek, Mirzaei, Mehdi and Walker, Adam K. (2024). A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration. Nature Communications, 15 (1) 1508, 1508. doi: 10.1038/s41467-024-45646-9
UndERACting ion channels in neurodegeneration
Jacobs, Matisse T., San Gil, Rebecca and Walker, Adam K. (2023). UndERACting ion channels in neurodegeneration. Trends in Neurosciences, 47 (2), 87-89. doi: 10.1016/j.tins.2023.11.002
Luan, Wei, Wright, Amanda L., Brown-Wright, Heledd, Le, Sheng, San Gil, Rebecca, Madrid San Martin, Lidia, Ling, Karen, Jafar-Nejad, Paymaan, Rigo, Frank and Walker, Adam K. (2023). Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD. Molecular Psychiatry, 28 (6), 2445-2461. doi: 10.1038/s41380-023-02036-9
Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43
Keating, Sean S., Bademosi, Adekunle T., San Gil, Rebecca and Walker, Adam K. (2023). Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43. Cellular and Molecular Life Sciences, 80 (4) 95, 1-23. doi: 10.1007/s00018-023-04739-2
TDP-43 pathology: from noxious assembly to therapeutic removal
Keating, Sean S., San Gil, Rebecca, Swanson, Molly E.V., Scotter, Emma L. and Walker, Adam K. (2022). TDP-43 pathology: from noxious assembly to therapeutic removal. Progress in Neurobiology, 211 102229, 102229. doi: 10.1016/j.pneurobio.2022.102229
Wright, Amanda L., Della Gatta, Paul A., Le, Sheng, Berning, Britt A., Mehta, Prachi, Jacobs, Kelly R., Gul, Hossai, San Gil, Rebecca, Hedl, Thomas J., Riddell, Winonah R., Watson, Owen, Keating, Sean S., Venturato, Juliana, Chung, Roger S., Atkin, Julie D., Lee, Albert, Shi, Bingyang, Blizzard, Catherine A., Morsch, Marco and Walker, Adam K. (2021). Riluzole does not ameliorate disease caused by cytoplasmic TDP‐43 in a mouse model of amyotrophic lateral sclerosis. European Journal of Neuroscience, 54 (6) ejn.15422, 6237-6255. doi: 10.1111/ejn.15422
San Gil, Rebecca, Clarke, Benjamin E., Ecroyd, Heath, Kalmar, Bernadett and Greensmith, Linda (2021). Regional differences in heat shock protein 25 expression in brain and spinal cord astrocytes of wild-type and SOD1 G93A mice. Cells, 10 (5) 1257, 1-18. doi: 10.3390/cells10051257
First person - Rebecca San Gil
San Gil, Rebecca (2020). First person - Rebecca San Gil. Journal of Cell Science, 133 (15) jcs251918, 1-2. doi: 10.1242/jcs.251918
Gil, R. San, Cox, D., McAlary, L., Berg, T., Walker, A. K., Yerbury, J. J., Ooi, L. and Ecroyd, H. (2020). Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells. Journal of Cell Science, 133 (15), 1-15. doi: 10.1242/jcs.243709
Proteomics approaches for biomarker and drug target discovery in ALS and FTD
Hedl, Thomas J., San Gil, Rebecca, Cheng, Flora, Rayner, Stephanie L., Davidson, Jennilee M., De Luca, Alana, Villalva, Maria D., Ecroyd, Heath, Walker, Adam K. and Lee, Albert (2019). Proteomics approaches for biomarker and drug target discovery in ALS and FTD. Frontiers in Neuroscience, 13 (JUN) 548, 548. doi: 10.3389/fnins.2019.00548
Regional differences in the inflammatory and heat shock response in glia: implications for ALS
Clarke, Benjamin E., Gil, Rebecca San, Yip, Jing, Kalmar, Bernadett and Greensmith, Linda (2019). Regional differences in the inflammatory and heat shock response in glia: implications for ALS. Cell Stress and Chaperones, 24 (5), 857-870. doi: 10.1007/s12192-019-01005-y
The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity
Cox, Dezerae, Whiten, Daniel R., Brown, James W. P., Horrocks, Mathew H., San Gil, Rebecca, Dobson, Christopher M., Klenerman, David, van Oijen, Antoine M. and Ecroyd, Heath (2018). The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity. Journal of Biological Chemistry, 293 (12), 4486-4497. doi: 10.1074/jbc.m117.813865
The heat shock response in neurons and astroglia and its role in neurodegenerative diseases
San Gil, Rebecca, Ooi, Lezanne, Yerbury, Justin J. and Ecroyd, Heath (2017). The heat shock response in neurons and astroglia and its role in neurodegenerative diseases. Molecular Neurodegeneration, 12 (1) 65. doi: 10.1186/s13024-017-0208-6
Using bicistronic constructs to evaluate the chaperone activities of heat shock proteins in cells
San Gil, Rebecca, Berg, Tracey and Ecroyd, Heath (2017). Using bicistronic constructs to evaluate the chaperone activities of heat shock proteins in cells. Scientific Reports, 7 (1) 2387. doi: 10.1038/s41598-017-02459-9
Rapid flow cytometric measurement of protein inclusions and nuclear trafficking
Whiten, D. R., San Gil, R., McAlary, L., Yerbury, J. J., Ecroyd, H. and Wilson, M. R. (2016). Rapid flow cytometric measurement of protein inclusions and nuclear trafficking. Scientific Reports, 6 (1) 31138. doi: 10.1038/srep31138
Oligodendrocytes and TDP-43 pathology in MND
(2024–2027) Cure for MND Foundation - Discovery Research Grants
Synaptic mechanisms of non-motor dysfunction in MND
(2024–2025) Motor Neurone Disease Research Institute of Australia Inc Innovator Grant
Defining the involvement of ubiquilin-2 in MND
(2021–2022) Motor Neurone Disease Research Institute of Australia Inc
Genome-wide CRISPR screen to reveal regulators of TDP-43 aggregation and toxicity in MND
(2020–2023) Cure for MND Foundation - Post Doctoral Research Fellowships
(2019–2020) Brain Foundation Research Gift
The Role of NFI Genes in Maintaining Astrocyte Differentiation
Doctor Philosophy — Associate Advisor
Other advisors:
TDP-43 and the autophagy-lysosome proteostasis system in the pathogenesis and treatment of ALS/FTD
Doctor Philosophy — Associate Advisor
Other advisors: