Dr Patrick Harris

Amplify Fellow

UQ Centre for Clinical Research
Faculty of Medicine
p.harris@uq.edu.au
+61 7 334 65476

Overview

Dr Patrick Harris is an Infectious Disease Physician, Medical Microbiologist and NHMRC Early Career Fellow at The University of Queensland Centre for Clinical Research (UQCCR).

Dr. Harris obtained a BSc in Psychology and Anthropology from Durham University, prior to acquiring his medical degree from University College London Medical School. Following postgraduate training in the UK, he worked as a clinical lecturer at the College of Medicine in Malawi, before completing specialist training in infectious diseases and microbiology in Australia. For his final year of training he was a Senior Visiting Fellow in Infectious Disease at the National University Hospital in Singapore. He completed his PhD in 2018 under the supervision of Prof. David Paterson, with a focus on multi-drug resistant Gram-negative bacteria.

Research Interests

  • Clinical trials
    Assessing the clinical impact of novel antibiotic treatment strategies for bloodstream infections
  • Antibiotic resistance
    Resistance in gram-negative pathogens such as E. coli, Klebsiella and Enterobacter
  • Clinical application of genomics
    Use of whole genome sequencing in clinical microbiology

Research Impacts

He has published more than 150 peer-reviewed articles, many as first or senior author, including JAMA, the Lancet, Lancet Infectious Diseases and Clinical Infectious Diseases. He was a lead investigator for the MERINO trial: an international multicentre study to compare carbapenem-sparing treatment options for ESBL and AmpC-producing species. This has been the first large RCT to specifically address this question, using a protocol developed and endorsed by the Australasian Society for Infectious Diseases Clinical Research Network (ASID-CRN). https://clinicaltrials.gov/ct2/show/NCT02176122. This was followed by the MERINO-2 trial: a randomised controlled trial of meropenem versus piperacillin-tazobactam for treatment of bloodstream infections due to AmpC-producing Enterobacter, Citrobacter, Serratia, Providencia and Morganella: https://clinicaltrials.gov/ct2/show/NCT02437045. His other main research interest includes the application of whole genome sequencing to clinical microbiology. He was the clinical lead for the Queensland Genomics Clinical Demonstration Project: Whole genome sequencing to track, treat and prevent nosocomial infections. This project has successfuly integrated a genomics workflow within Queensland health, to support outbreak response and surveillance of hospital acqured multi-drug resistant infections: Hospital acquired infections – Queensland Genomics

Qualifications

  • Doctor of Philosophy, The University of Queensland
  • Bachelor of Medicine and Surgery and Medical Science, University of London

Publications

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Grants

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Supervision

View all Supervision

Publications

Book Chapter

  • Bennett, Harrison Y., Harris, Patrick N., Holmes, Michael, Grummet, Jeremy and Roberts, Matthew (2018). Prostate biopsy related infection – risk factors, prevention strategies and management approaches. Urogenital infections and inflammations. (pp. 1-30) edited by T.E. Bjerklund Johansen, F. M.E. Wagenlehner, Y.-H. Cho, T. Matsumoto, J. N. Krieger, D. Shoskes and K. Naber. Berlin, Germany: GMS Publishing House. doi: 10.5680/lhuii000040

  • Peleg, A. Y. and Harris, P. (2017). Meropenem / Meropenem-vaborbactam. Kucers' the Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic and Antiviral Drugs. (pp. 697-722) edited by Lindsay Grayson. Boca Raton, FL United States: Taylor & Francis. doi: 10.1201/9781315152110

Journal Article

Conference Publication

Other Outputs

Grants (Administered at UQ)

PhD and MPhil Supervision

Current Supervision

  • Doctor Philosophy — Principal Advisor

    Other advisors:

  • Doctor Philosophy — Principal Advisor

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

    Other advisors:

  • Doctor Philosophy — Associate Advisor

  • Doctor Philosophy — Associate Advisor

Completed Supervision