Senior Research Fellow
Room 7048, Level 7, Pharmacy Australia Centre of Excellence Phone:+61 7 334-61898; Fax: +61 7 334-61999 Email: a.hewavitharana@pharmacy.uq.edu.au
Amitha obtained her B.Sc. from the University of Colombo (Sri Lanka), M.Sc. from the university of Victoria (B.C., Canada) and PhD in analytical chemistry from the University of Alberta (Canada). Following that, she held brief research positions at the Massey University (New Zealand) and NZ Leather Research Institute. She then held a research scientist position at the NZ Dairy Research Institute (NZDRI, currently Fonterra Research) for 4 years before moving to Australia in 1997.
In Australia, she commenced her career as a lecturer in analytical chemistry at the University of Western Sydney, and then at Queensland University of Technology (QUT) until 2001. Following that, she held research positions in CSIRO (food science) and in QHSS (investigative chemistry) before joining the school of pharmacy in 2004.
Journal Article: Using a global diversity panel of Cannabis sativa L. to develop a near InfraRed-based chemometric application for cannabinoid quantification
Gloerfelt-Tarp, Francine, Hewavitharana, Amitha K., Mieog, Jos, Palmer, William M., Fraser, Felicity, Ansari, Omid and Kretzschmar, Tobias (2023). Using a global diversity panel of Cannabis sativa L. to develop a near InfraRed-based chemometric application for cannabinoid quantification. Scientific Reports, 13 (1) 2253, 1-14. doi: 10.1038/s41598-023-29148-0
Journal Article: A one-step grafting methodology can adjust stem morphology and increase THCA yield in medicinal cannabis
Purdy, Sarah Jane, Hewavitharana, Amitha K., Halimi, Razlin Azman, Magner, Nelson Joel, Peterswald, Tyson James, Trebilco, Amy, Kretzschmar, Tobias and Hailstones, Deborah (2022). A one-step grafting methodology can adjust stem morphology and increase THCA yield in medicinal cannabis. Agronomy, 12 (4) 852. doi: 10.3390/agronomy12040852
Journal Article: Simultaneous quantification of 17 cannabinoids in cannabis inflorescence by liquid chromatography-mass spectrometry
Hewavitharana, Amitha K., Gloerfelt-Tarp, Francine, Nolan, Matthew, Barkla, Bronwyn J., Purdy, Sarah and Kretzschmar, Tobias (2022). Simultaneous quantification of 17 cannabinoids in cannabis inflorescence by liquid chromatography-mass spectrometry. Separations, 9 (4) 85. doi: 10.3390/separations9040085
Developing a method for measuring thiopurine drug and metabolites
(2018) Research Donation Generic
(2010) UQ Major Equipment and Infrastructure
Investigation of Selective Anti-Proliferative and Immunomodulatory Properties of Carica Papaya
(2017) Doctor Philosophy
Development of an assay for total vitamin D content in milk and application to study the effect of pasteurisation in breastmilk
(2016) Doctor Philosophy
Investigation of bioactive compounds with anti-cancer potential in Carica papaya leaves
(2016) Doctor Philosophy
Cholecalciferol: Properties and Determination
Hewavitharana, A. K. and Gomes, F. P. (2015). Cholecalciferol: Properties and Determination. Encyclopedia of Food and Health. (pp. 42-46) Oxford, United Kingdom: Elsevier . doi: 10.1016/B978-0-12-384947-2.00148-3
Gloerfelt-Tarp, Francine, Hewavitharana, Amitha K., Mieog, Jos, Palmer, William M., Fraser, Felicity, Ansari, Omid and Kretzschmar, Tobias (2023). Using a global diversity panel of Cannabis sativa L. to develop a near InfraRed-based chemometric application for cannabinoid quantification. Scientific Reports, 13 (1) 2253, 1-14. doi: 10.1038/s41598-023-29148-0
Purdy, Sarah Jane, Hewavitharana, Amitha K., Halimi, Razlin Azman, Magner, Nelson Joel, Peterswald, Tyson James, Trebilco, Amy, Kretzschmar, Tobias and Hailstones, Deborah (2022). A one-step grafting methodology can adjust stem morphology and increase THCA yield in medicinal cannabis. Agronomy, 12 (4) 852. doi: 10.3390/agronomy12040852
Hewavitharana, Amitha K., Gloerfelt-Tarp, Francine, Nolan, Matthew, Barkla, Bronwyn J., Purdy, Sarah and Kretzschmar, Tobias (2022). Simultaneous quantification of 17 cannabinoids in cannabis inflorescence by liquid chromatography-mass spectrometry. Separations, 9 (4) 85. doi: 10.3390/separations9040085
Hewavitharana, Amitha K., Shaw, P. Nicholas, Smyth, H. D.C., Samaranayake, L. P. and Bandara, H. M.H.N. (2021). The importance of complete overlapping of analyte and internal standard peaks in eliminating matrix effects with liquid chromatography–mass spectrometry (Lc–ms). LC-GC North America, 39 (7), 335-338.
Zou, Zhengzheng, Bauland, Julien, Hewavitharana, Amitha K., Al-Shehri, Saad S., Duley, John A., Cowley, David M., Koorts, Pieter, Shaw, Paul N. and Bansal, Nidhi (2021). A sensitive, high-throughput fluorescent method for the determination of lactoperoxidase activities in milk and comparison in human, bovine, goat and camel milk. Food Chemistry, 339 128090, 128090. doi: 10.1016/j.foodchem.2020.128090
Zou, Zhengzheng, Bouchereau-De Pury, Claire, Hewavitharana, Amitha K., Al-Shehri, Saad S., Duley, John A., Cowley, David M., Koorts, Pieter, Shaw, Paul N. and Bansal, Nidhi (2021). A sensitive and high-throughput fluorescent method for determination of oxidase activities in human, bovine, goat and camel milk. Food Chemistry, 336 127689, 127689. doi: 10.1016/j.foodchem.2020.127689
A novel, quorum sensor-infused liposomal drug delivery system suppresses Candida albicans biofilms
Bandara, H. M.H.N., Hewavitharana, A. K., Shaw, P. N., Smyth, H. D.C. and Samaranayake, L. P. (2020). A novel, quorum sensor-infused liposomal drug delivery system suppresses Candida albicans biofilms. International Journal of Pharmaceutics, 578 119096, 119096. doi: 10.1016/j.ijpharm.2020.119096
Pandey, Saurabh, Walpole, Carina, Shaw, Paul N., Cabot, Peter J., Hewavitharana, Amitha K. and Batra, Jyotsna (2018). Bio-Guided Fractionation of Papaya Leaf Juice for Delineating the Components Responsible for the Selective Anti-proliferative Effects on Prostate Cancer Cells. Frontiers in Pharmacology, 9 (NOV) 1319, 1319. doi: 10.3389/fphar.2018.01319
Hewavitharana, Amitha K., Narayan, Vicrant and Duley, John A. (2018). Separation of highly charged compounds using competing ions with hydrophilic interaction liquid chromatography - application to assay of cellular nucleotides. Journal of Chromatography A, 1567, 233-238. doi: 10.1016/j.chroma.2018.07.006
Hewavitharana, Amitha K., Abu Kassim, Nur Sofiah and Shaw, Paul Nicholas (2018). Standard addition with internal standardisation as an alternative to using stable isotope labelled internal standards to correct for matrix effects-Comparison and validation using liquid chromatography-tandem mass spectrometric assay of vitamin D. Journal of Chromatography A, 1553, 101-107. doi: 10.1016/j.chroma.2018.04.026
Abu Kassim, Nur Sofiah, Shaw, Paul Nicholas and Hewavitharana, Amitha K. (2017). Simultaneous determination of 12 vitamin D compounds in human serum using online sample preparation and liquid chromatography-tandem mass spectrometry. Journal of Chromatography A, 1533, 57-65. doi: 10.1016/j.chroma.2017.12.012
Selective anti-proliferative activities of Carica papaya leaf juice extracts against prostate cancer
Pandey, Saurabh, Walpole, Carina, Cabot, Peter J., Shaw, Paul N., Batra, Jyotsna and Hewavitharana, Amitha K. (2017). Selective anti-proliferative activities of Carica papaya leaf juice extracts against prostate cancer. Biomedicine & Pharmacotherapy, 89, 515-523. doi: 10.1016/j.biopha.2017.02.050
Morgan, M., Heffernan, A., Benhabib, F., Wagner, S., Hewavitharana, A. K., Shaw, P. N. and Cabot, P. J. (2017). The efficacy of Dynorphin fragments at the κ, μ and δ opioid receptor in transfected HEK cells and in an animal model of unilateral peripheral inflammation. Peptides, 89, 9-16. doi: 10.1016/j.peptides.2016.12.019
Bose, Utpal, Ortori, Catharine A., Sarmad, Sarir , Barrett, David A., Hewavitharana, Amitha K. , Hodson, Mark P., Fuerst, John A. and Shaw, P. Nicholas (2017). Production of N-acyl homoserine lactones by the sponge-associated marine actinobacteria Salinispora arenicola and Salinispora pacifica. FEMS Microbiology Letters, 364 (2) fnx002. doi: 10.1093/femsle/fnx002
To investigate the effect of the pasteurisation process on trace elements in donor breast milk
Taufek, Nor Mohd, Cartwright, David, Hewavitharana, Amitha, Koorts, Pieter, McConachy, Helen, Shaw, Nick, Whitfield, Karen and Davies, Mark (2016). To investigate the effect of the pasteurisation process on trace elements in donor breast milk. e ADC, 101 (9), A13-A14. doi: 10.1136/archdischild-2016-311535.27
Anti-inflammatory and immunomodulatory properties of Carica papaya
Pandey, Saurabh, Cabot, Peter J., Shaw, P. Nicholas and Hewavitharana, Amitha K. (2016). Anti-inflammatory and immunomodulatory properties of Carica papaya. Journal of Immunotoxicology, 13 (4), 590-602. doi: 10.3109/1547691X.2016.1149528
The effect of pasteurization on trace elements in donor breast milk
Mohd-Taufek, N., Cartwright, D., Davies, M., Hewavitharana, A. K., Koorts, P., McConachy, H., Shaw, P. N., Sumner, R. and Whitfield, K. (2016). The effect of pasteurization on trace elements in donor breast milk. Journal of Perinatology, 36 (10), 897-900. doi: 10.1038/jp.2016.88
Simultaneous quantitative analysis of nine vitamin D compounds in human blood using LC-MS/MS
Abu Kassim, Nur Sofiah, Gomes, Fabio P., Shaw, Paul Nicholas and Hewavitharana, Amitha K. (2016). Simultaneous quantitative analysis of nine vitamin D compounds in human blood using LC-MS/MS. Bioanalysis, 8 (5), 397-411. doi: 10.4155/bio.15.260
Nguyen, Thao T., Parat, Marie-Odile, Shaw, Paul N., Hewavitharana, Amitha K. and Hodson, Mark P. (2016). Traditional aboriginal preparation alters the chemical profile of carica papaya leaves and impacts on cytotoxicity towards human squamous cell carcinoma. PLoS ONE, 11 (2) e0147956, e0147956. doi: 10.1371/journal.pone.0147956
Effect of pasteurisation on the concentrations of vitamin D compounds in donor breastmilk
Gomes, Fabio P., Shaw, P. Nicholas, Whitfield, Karen, Koorts, Pieter, McConachy, Helen and Hewavitharana, Amitha K. (2016). Effect of pasteurisation on the concentrations of vitamin D compounds in donor breastmilk. International Journal of Food Sciences and Nutrition, 67 (1), 16-19. doi: 10.3109/09637486.2015.1126566
Gomes, Fabio P., Shaw, P. Nicholas and Hewavitharana, Amitha K. (2016). Determination of four sulfated vitamin D compounds in human biological fluids by liquid chromatography-tandem mass spectrometry. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 1009-1010, 80-86. doi: 10.1016/j.jchromb.2015.12.014
The simultaneous analysis of eight essential trace elements in human milk by ICP-MS
Mohd-Taufek, Nor, Cartwright, David, Davies, Mark, Hewavitharana, Amitha K., Koorts, Pieter, Shaw, Paul N., Sumner, Ronald, Lee, Eugene and Whitfield, Karen (2016). The simultaneous analysis of eight essential trace elements in human milk by ICP-MS. Food Analytical Methods, 9 (7), 1-8. doi: 10.1007/s12161-015-0396-z
Nguyen, Thao T., Parat, Marie-Odile, Hodson, Mark P., Pan, Jenny, Shaw, Paul N. and Hewavitharana, Amitha K. (2016). Chemical characterization and in vitro cytotoxicity on squamous cell carcinoma cells of Carica papaya leaf extracts. Toxins, 8 (1), 7.1-7.11. doi: 10.3390/toxins8010007
Al-Shehri, Saad S., Knox, Christine L., Liley, Helen G., Cowley, David M., Wright, John R., Henman, Michael G., Hewavitharana, Amitha K., Charles, Bruce G., Shaw, Paul N., Sweeney, Emma L. and Duley, John A. (2015). Breastmilk-saliva interactions boost innate immunity by regulating the oral microbiome in early infancy. PLoS One, 10 (9) e0135047, e0135047.1-e0135047.19. doi: 10.1371/journal.pone.0135047
Bose, Utpal, Hewavitharana, Amitha K., Ng, Yi Kai, Shaw, Paul Nicholas, Fuerst, John A. and Hodson, Mark P. (2015). LC-MS-Based Metabolomics Study of Marine Bacterial Secondary Metabolite and Antibiotic Production in Salinispora arenicola.. Marine Drugs, 13 (1), 249-266. doi: 10.3390/md13010249
Review of procedures used for the extraction of anti-cancer compounds from tropical plants
Pandey, Saurabh, Shaw, Paul N. and Hewavitharana, Amitha K. (2015). Review of procedures used for the extraction of anti-cancer compounds from tropical plants. Anti-Cancer Agents in Medicinal Chemistry, 15 (3), 314-326. doi: 10.2174/1871520614666141114202104
Gomes, Fabio P., Shaw, P. Nicholas, Whitfield, Karen and Hewavitharana, Amitha K. (2015). Simultaneous quantitative analysis of eight vitamin D analogues in milk using liquid chromatographyetandem mass spectrometry. Analytica Chimica Acta, 891 234099, 211-220. doi: 10.1016/j.aca.2015.08.017
Effects of salinity on antibiotic production in sponge-derived Salinispora actinobacteria
Ng, Y. K., Hodson, M. P., Hewavitharana, A. K., Bose, U., Shaw, P. N. and Fuerst, J. A. (2014). Effects of salinity on antibiotic production in sponge-derived Salinispora actinobacteria. Journal of Applied Microbiology, 117 (1), 109-125. doi: 10.1111/jam.12507
Bose, Utpal, Hewavitharana, Amitha K., Vidgen, Miranda E., Ng, Yi Kai, Shaw, Nicholas, Fuerst, John A. and Hodson, Mark P. (2014). Discovering the recondite secondary metabolome spectrum of Salinispora species: a study of inter-species diversity. PLoS One, 9 (3) e91488, e91488.1-e91488.10. doi: 10.1371/journal.pone.0091488
Bacterial production of the fungus-derived cholesterol-lowering agent mevinolin
Bose, Utpal, Hodson, Mark P., Shaw, P. Nicholas, Fuerst, John A. and Hewavitharana, Amitha K. (2014). Bacterial production of the fungus-derived cholesterol-lowering agent mevinolin. Biomedical Chromatography, 28 (9), 1163-1166. doi: 10.1002/bmc.3138
Beta-Endorphin 1-31 Biotransformation and cAMP Modulation in Inflammation
Asvadi, Naghmeh Hajarol, Morgan, Michael, Herath, Herath M., Hewavitharana, Amitha K., Shaw, P. Nicholas and Cabot, Peter J. (2014). Beta-Endorphin 1-31 Biotransformation and cAMP Modulation in Inflammation. PLoS One, 9 (3) e90380, e90380.1-e90380.11. doi: 10.1371/journal.pone.0090380
Biotransformation of beta-endorphin and possible therapeutic implications
Asvadi, Naghmeh H., Morgan, Michael, Hewavitharana, Amitha K., Shaw, P. Nicholas and Cabot, Peter J. (2014). Biotransformation of beta-endorphin and possible therapeutic implications. Frontiers in Pharmacology, 5 (Article 18) Article 18, 18. doi: 10.3389/fphar.2014.00018
Hewavitharana, Amitha K., Darch, Katherine M. and Shaw, P. Nicholas (2014). Hydrophilic interaction liquid chromatography-tandem mass spectrometric determination of creatinine in human urine. Analytical Letters, 47 (4), 689-696. doi: 10.1080/00032719.2013.848363
Strategies for the detection and elimination of matrix effects in quantitative LC-MS analysis
Hewavitharana, Amitha K., Tan, Swee K. and Shaw, P. Nicholas (2014). Strategies for the detection and elimination of matrix effects in quantitative LC-MS analysis. LCGC North America, 32 (1), 54-64.
Bose, Utpal, Hodson, Mark P., Shaw, P. Nicholas, Fuerst, John A. and Hewavitharana, Amitha K. (2014). Two peptides, Cycloaspeptide A and Nazumamide A from a sponge associated marine Actinobacterium Salinispora sp. Natural Product Communications, 9 (4), 545-546. doi: 10.1177/1934578x1400900431
Inaccuracies in the quantification of peptides - A case study using beta-endorphin assay
Herath, H. M. D. R., Kim, R-R., Cabot, P. J., Shaw, P. N. and Hewavitharana, A. K. (2013). Inaccuracies in the quantification of peptides - A case study using beta-endorphin assay. LCGC Europe, 26 (8), 435-437.
Hewavitharana, Amitha K., Tan, Zhi W., Shimada, Ryo, Shaw, Paul N. and Flanagan, Bernadine M. (2013). Between fruit variability of the bioactive compounds, β-carotene and mangiferin, in mango (Mangifera indica). Nutrition and Dietetics, 70 (2), 158-163. doi: 10.1111/1747-0080.12009
Hewavitharana, Amitha (2013). Current status of Vitamin D assays: are they reliable and sufficiently informative for clinical studies?. Bioanalysis, 5 (11), 1325-1327. doi: 10.4155/BIO.13.88
Anticancer activity of Carica papaya: a review
Nguyen, Thao T. T., Shaw, Paul N., Parat, Marie-Odile and Hewavitharana, Amitha K. (2013). Anticancer activity of Carica papaya: a review. Molecular Nutrition and Food Research, 57 (1), 153-164. doi: 10.1002/mnfr.201200388
Ng, Yi Kai, Hewavitharana, Amitha K., Webb, Richard, Shaw, P. Nicholas and Fuerst, John A. (2013). Developmental cycle and pharmaceutically relevant compounds of Salinospora actinbacteria isolated from Great Barrier Reef marine sponges. Applied Microbiology and Biotechnology, 97 (7), 3097-3108. doi: 10.1007/s00253-012-4479-0
Inaccuracies in the quantification of peptides - a case study using beta-endorphin assay
Herath, H. M. D. R., Kim, R. -R., Cabot, P. J., Shaw, P. N. and Hewavitharana, A. K. (2013). Inaccuracies in the quantification of peptides - a case study using beta-endorphin assay. LCGC North America, 31 (1), 58-61.
Recent trends in the determination of vitamin D
Gomes, Fabio P., Shaw, P. Nicholas, Whitfield, Karen, Koorts, Pieter and Hewavitharana, Amitha K. (2013). Recent trends in the determination of vitamin D. Bioanalysis, 5 (24), 3063-3078. doi: 10.4155/bio.13.283
Soliman, Laiel C., Hui, Yu, Hewavitharana, Amitha K. and Chen, David D. Y. (2012). Monitoring potential prostate cancer biomarkers in urine by capillary electrophoresis-tandem mass spectrometry. Journal of Chromatography A, 1267 (7), 162-169. doi: 10.1016/j.chroma.2012.07.021
Morgan, M., Herath, H. M. D. R., Cabot, P. J., Shaw, P. N. and Hewavitharana, A. K. (2012). Dynorphin A 1–17 biotransformation in inflamed tissue, serum and trypsin solution analysed by liquid chromatography–tandem mass spectrometry. Analytical and Bioanalytical Chemistry, 404 (10), 3111-3121. doi: 10.1007/s00216-012-6406-8
Dilanthi, H. M. D. R., Cabot, P. J., Shaw, P. N. and Hewavitharana, A. K. (2012). Study of beta endorphin metabolism in inflamed tissue, serum and trypsin solution by liquid chromatography-tandem mass spectrometric analysis. Analytical and Bioanalytical Chemistry, 402 (6), 2089-2100. doi: 10.1007/s00216-011-5686-8
Hewavitharana, Amitha K. (2011). Matrix matching in liquid chromatography-mass spectrometry with stable isotope labelled internal standards - Is it necessary?. Journal of Chromatography A, 1218 (2), 359-361. doi: 10.1016/j.chroma.2010.11.047
Wilkinson, Ashley, Flanagan, Bernadine M., Pierson, Jean-Thomas, Hewavitharana, Amitha, Dietzgen, Ralf G., Shaw, Paul N., Roberts-Thomson, Sarah J., Monteith, Gregory R. and Gidley, Mike (2011). Bioactivity of mango flesh and peel extracts on peroxisome proliferator-activated receptor gamma [PPARgamma] activation and MCF-7 cell proliferation: Fraction and fruit variability. Journal of Food Science, 76 (1), 11-18. doi: 10.1111/j.1750-3841.2010.01899.x
Hewavitharana, A. K., Herath, H. M. D. R., Shaw, P. N., Cabot, P. N. and Kebarle, P. (2010). Effect of solvent and electrospray mass spectrometer parameters on the charge state distribution of peptides - a case study using liquid chromatography/mass spectrometry method development for beta-endorphin assay. Rapid Communications in Mass Spectrometry, 24 (24), 3510-3514. doi: 10.1002/rcm.4806
Izumi, Hiroshi, Gauthier, Marie E.A., Degnan, Bernard M., Ng, Yi Kai, Hewavitharana, Amitha K., Shaw, P. Nicholas and Fuerst, John A. (2010). Diversity of Mycobacterium species from marine sponges and their sensitivity to antagonism by sponge-derived rifamycin-synthesizing actinobacteria in genus Salinispora. FEMS Microbiology Letters, 313 (1), 33-40. doi: 10.1111/j.1574-6968.2010.02118.x
Hewavitharana, Amitha (2010). Re: Florian Jentzmik, Carsten Stephan, Kurt Miller, et al. Sarcosine in Urine After Digital Rectal Examination Fails as a Marker in Prostate Cancer Detection and Identification of Aggressive Tumours. Eur Urol 2010;58:12-8. European Eurology, 58 (4), E39-E40. doi: 10.1016/j.eururo.2010.07.031
Herath, H. M. D. R., Shaw, Paul N., Cabot, Peter and Hewavitharana, Amitha (2010). Effect of ionization suppression by trace impurities in mobile phase water on the accuracy of quantification by high-performance liquid chromatography/mass spectrometry. Rapid Communications in Mass Spectrometry, 24 (11), 1502-1506. doi: 10.1002/rcm.4549
Mango extracts and the mango component mangiferin promote endothelial cell migration
Daud, Noor Huda, Aung, Cho Sanda, Hewavitharana, Amitha K., Wilkinson, Ashley S., Pierson, Jean-Thomas, Roberts-Thomson, Sarah J., Shaw, P. Nicholas, Monteith, Gregory R., Gidley, Michael J. and Parat, Marie-Odile (2010). Mango extracts and the mango component mangiferin promote endothelial cell migration. Journal of Agricultural and Food Chemistry, 58 (8), 5181-5186. doi: 10.1021/jf100249s
Mutalik, S., Hewavitharana, A., Shaw, P. N., Anissimov, Y. G., Roberts, M. S. and Parekh, H. S. (2009). Development and validation of a reversed-phase high-performance liquid chromatographic method for quantification of peptide dendrimers in human skin permeation experiments. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 877 (29), 3556-3562. doi: 10.1016/j.jchromb.2009.08.039
Internal standard - friend or foe?
Hewavitharana, Amitha (2009). Internal standard - friend or foe?. Critical Reviews in Analytical Chemistry, 39 (4), 272-275. doi: 10.1080/10408340903001201
Hewavitharana, A., Shaw, P. N., Ng, Y. K. and Fuerst, J. A. (2009). Simple screening method for staurosporine in bacterial cultures using liquid chromatography-tandem mass spectrometry. Journal of Bioanalysis & Biomedicine, 1 (1), 1-4. doi: 10.4172/1948-593X.1000001
Hewavitharana, A., Lee, S., Dawson, P. A., Markovich, D. and Shaw, P. N. (2008). Development of an HPLC-MS/MS method for the selective determination of paracetamol metabolites in mouse urine. Analytical Biochemistry, 374 (1), 106-111. doi: 10.1016/j.ab.2007.11.011
Bruce, H. L., Hewavitharana, A. K. and Hunter, R. A. (2008). Creatinine and pseudouridine in plasma and urine from Braham-cross steers fed a low, medium or high plane of nutrition. Livestock Science, 119 (1-3), 95-101. doi: 10.1016/j.livsci.2008.03.006
Screening of rifamycin producing marine sponge bacteria by LC-MS-MS
Hewavitharana, A. K., Shaw, P. N., Kim, T. K. and Fuerst, J. A. (2007). Screening of rifamycin producing marine sponge bacteria by LC-MS-MS. Journal of Chromatography B-analytical Technologies In The Biomedical And Life Sciences, 852 (1-2), 362-366. doi: 10.1016/j.jchromb.2007.01.042
Pham, H. L., Ross, B. P., McGeary, R. P., Shaw, P. N., Hewavitharana, A. K. and Davies, N. M. (2006). Saponins from Quillaja saponaria Molina: Isolation, Characterization and Ability to Form Immuno Stimulatory Complexes (ISCOMs). Current Drug Delivery, 3 (4), 389-397. doi: 10.2174/156720106778559092
Lee, S., Dawson, P. A., Hewavitharana, A. K., Shaw, P. N. and Markovich, D. (2006). Disruption of NaS1 sulfate transport function in mice leads to enhanced acetaminophen-induced hepatotoxicity. Hepatology, 43 (6), 1241-1247. doi: 10.1002/hep.21207
Kim, T. K., Hewavitharana, A. K., Shaw, P. N. and Fuerst, J. A. (2006). Discovery of a new source of rifamycin antibiotics in marine sponge actinobacteria by phylogenetic prediction. Applied And Environmental Microbiology, 72 (3), 2118-2125. doi: 10.1128/AEM.72.3.2118-2125.2006
Hewavitharana, A. K., Hyde, C., Thomas, R. and Shaw, P. N. (2006). Shortcomings of protein removal prior to high performance liquid chromatographic analysis - A case study using method development for BAY 11-7082. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 834 (1-2), 93-97. doi: 10.1016/j.jchromb.2006.02.037
Hewavitharana, AK and Shaw, PN (2005). Enhancing the ratio of molecular ions to non-covalent compounds in the electrospray interface of LC-MS in quantitative analysis. Analytical And Bioanalytical Chemistry, 382 (4), 1055-1059. doi: 10.1007/s00216-005-3236-y
Quantitative GG-MS analysis of Delta(9)-tetrahydrocannabinol in fiber hemp varieties
Hewavitharana, A.K., Golding, G., Tempany, G., King, G. and Holling, N. (2005). Quantitative GG-MS analysis of Delta(9)-tetrahydrocannabinol in fiber hemp varieties. Journal of Analytical Toxicology, 29 (4), 258-261. doi: 10.1093/jat/29.4.258
Lanari, MC, Hewavitharana, AK, Becu, C and de Jong, S (2004). Effect of dietary tocopherols and tocotrienols on the antioxidant status and lipid stability of chicken. Meat Science, 68 (2), 155-162. doi: 10.1016/j.meatsci.2003.12.004
Hewavitharana, A. K., Lanari, M. C. and Becu, C. (2004). Simultaneous determination of Vitamin E homologs in chicken meat by liquid chromatography with fluorescence detection. Journal of Chromatography A, 1025 (2), 313-317. doi: 10.1016/j.chroma.2003.10.052
Hewavitharana, AK (2003). Simple solutions to problems encountered in quantitative analysis of tocopherols and tocotrienols using silica columns. Analytical Biochemistry, 313 (2), 342-344. doi: 10.1016/S0003-2697(02)00589-4
Hewavitharana, AK and Bruce, HL (2003). Simultaneous determination of creatinine and pseudouridine concentrations in bovine plasma by reversed-phase liquid chromatography with photodiode array detection. Journal of Chromatography B-analytical Technologies In The Biomedical And Life Sciences, 784 (2), 275-281. doi: 10.1016/S1570-0232(02)00799-7
Hewavitharana, A. K. and Bruce, H. L. (2003). Simultaneous liquid chromatographic determination of creatinine and pseudouridine in bovine urine and the effect of sample pH on the analysis. Journal of Agricultural And Food Chemistry, 51 (17), 4861-4865. doi: 10.1021/jf030095z
Hewavitharana, A. K. and Van Brakel, A. S. (1998). A rapid saponification procedure for the simultaneous HPLC determination of the natural levels of vitamins A, E and beta-carotene in milk. Milchwissenschaft-Milk Science International, 53 (1), 11-15.
Chromatographic problems related to mobile phase degassing and fluorescence detection
van Brakel, A. S., Matheson, A. R. and Hewavitharana, A. K. (1997). Chromatographic problems related to mobile phase degassing and fluorescence detection. Journal of Chromatographic Science, 35 (11), 545-548. doi: 10.1093/chromsci/35.11.545
Fourier transform infrared spectrometric method for the rapid determination of casein in raw milk
Hewavitharana, A. K. and van Brakel, B. (1997). Fourier transform infrared spectrometric method for the rapid determination of casein in raw milk. Analyst, 122 (7), 701-704. doi: 10.1039/a700953d
Lysinoalanine determination in sodium caseinate using the LKB Alpha Plus Amino Acid Analyser
Wilkinson, J. and Hewavitharana, A. K. (1997). Lysinoalanine determination in sodium caseinate using the LKB Alpha Plus Amino Acid Analyser. Milchwissenschaft-Milk Science International, 52 (8), 423-427.
Hewavitharana, A. K. (1996). Method for the extraction of riboflavin for high-performance liquid chromatography and application to casein. Analyst, 121 (11), 1671-1676. doi: 10.1039/an9962101671
Hewavitharana, A. K., van Brakel, A. S. and Harnett, M. (1996). Simultaneous liquid chromatographic determination of vitamins A, E and beta-carotene in common dairy foods. International Dairy Journal, 6 (6), 613-624. doi: 10.1016/0958-6946(95)00057-7
Hewavitharana, A. K. (1993). A Fast and Efficient Hplc Method for the Separation of Chromium Complexes in Chrome Tanning Solutions. Journal of the Society of Leather Technologists and Chemists, 77 (5), 143-146.
Hewavitharana, A. K. and Kratochvil, B. (1993). An Ion-Exchange Atomic-Absorption Method for the Measurement of Ionized Calcium and Magnesium At Micromolar Concentrations. Canadian Journal of Chemistry-Revue Canadienne De Chimie, 71 (1), 17-20. doi: 10.1139/v93-002
Hewavitharana, A. K., Mutucumarana, V. and Kratochvil, B. (1991). An Ion-Exchange Atomic-Absorption Method for the Determination of Ionized Calcium At Millimolar Levels. Canadian Journal of Chemistry-Revue Canadienne De Chimie, 69 (12), 1976-1979. doi: 10.1139/v91-284
Kirk, A. D. and Hewavitharana, A. K. (1988). Reversed-Phase Chromatographic-Separation of Highly Charged Inorganic Cations and Anions Using Ion Interaction Reagents and Competing Ions. Analytical Chemistry, 60 (8), 797-801. doi: 10.1021/ac00159a013
Effect of pasteurisation on the concentrations of vitamin D compounds in donor breast milk
Gomes, Fabio, Shaw, Nick, Whitfield, Karen, Koorts, Pieter, McConachy, Helen and Hewavitharana, Amitha (2016). Effect of pasteurisation on the concentrations of vitamin D compounds in donor breast milk. Neonatal and Paediatric Pharmacists Group (NPPG) 21st Annual Conference, London, United Kingdom, 6–8 November 2015. London, United Kingdom: BMJ Group. doi: 10.1136/archdischild-2016-311535.26
Pandey, Saurabh, Walpole, Carina, Cabot, Peter J., Shaw, Paul N., Batra, Jyotsna and Hewavitharana, Amitha K. (2016). Medium polarity fraction of papaya leaf juice has selective antiproliferative effects on prostate cancer cells. 17th Asia-Pacific Prostate Cancer Conference, Melbourne, Australia, Aug 31-Sep 03, 2016. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/bju.13567
Carica papaya leaf juice extracts have selective anti-proliferative responses in prostatic disease
Walpole, Carina, Pandey, Saurabh, Cabot, Peter J., Shaw, Paul N., Batra, Jyotsna and Hewavitharana, Amitha K. (2015). Carica papaya leaf juice extracts have selective anti-proliferative responses in prostatic disease. 2nd Prostate Cancer World Congress (PCWC), Cairns, QLD Australia, 17-21 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/bju.13198
Investigation of compounds with cytotoxic activity in Carica papaya leaves
Nguyen, Thao, Parat, Marie-Odile, Hodson, Mark P., Shaw, P. Nicholas and Hewavitharana, Amitha K. (2014). Investigation of compounds with cytotoxic activity in Carica papaya leaves. ICDDT 2014: 6th International Conference on Drug Discovery and Therapy, Dubai, United Arab Emirates, February 2014. Saif Zone, Sharjah, UAE:
Asvadi, Naghmeh Hajarol, Morgan, Michael, Hewavitharana, Amitha, Shaw, P. Nicholas and Cabot, Peter J. (2013). Biotransformation within inflamed tissue of beta-endorphin 1-31 and three major N-terminal fragments; beta-endorphin 1-17, beta-endorphin 1-13, and beta-endorphin 1-11. HPLC 2013: 40th International Symposium on High Performance Liquid Phase Separations and Related Techniques, Hobart, TAS, Australia, 18-21 November, 2013. Royal Australian Chemical Institute (raci).
Bose, Utpal, Hodson, Mark, Vidgen, M., Shaw, N., Fuerst, J. and Hewavitharana, A. (2013). Chemical diversity of marine bacteria Salinispora arenicola and "Salinispora pacifica" associated with the host sponges Dercitus xanthus and Cinahyrella australiensis. The 9th International Sponge Conference, Fremantle, WA, Australia, 2013.
Bose, Utpal, Hodson, Mark P., Shaw, P. Nicholas, Fuerst, John A. and Hewavitharana, Amitha K. (2013). Discovering the hidden secondary metabolome of Salinispora arenicola: a study of intra-specific diversity. ICEC 2013: International Chemical Ecology Conference, Melbourne, VIC, Australia, 19-23 August, 2013.
Bose, Utpal, Hodson, Mark P., Shaw, P. Nicholas, Fuerst, John A. and Hewavitharana, Amitha K. (2013). Intraspecific variability in secondary metabolites of the Great Barrier Reef sponge-associated marine bacteria "Salinispora pacifica". IMBC 2013: 10th International Marine Biotechnology Conference, South Bank, QLD, Australia, 11-15 November, 2013.
Bose, U., Hewavitharana, A. K., Vidgen, M. E., Shaw, P. N., Fuerst, J. A. and Hodson, M. P. (2013). Liquid chromatography-mass spectrometry metabolomic profiling to explore inter-species diversity in the genus Salinispora. FEMS 2013: 5th Congress of European Microbiologists, Leipzig, Germany, 21-25 July, 2013.
Patterns of chemical diversity on sponge associated marine bacteria
Bose, Utpal, Hodson, Mark P., Vidgen, Miranda E., Shaw, P. Nicholas, Fuerst, John A. and Hewavitharana, Amitha K. (2013). Patterns of chemical diversity on sponge associated marine bacteria. 9th Annual Conference of the Metabolomics Society, Glasgow, Scotland, U.K., 1-4 July, 2013.
The biotransformation of beta-endorphin in the rat brain after a single sedating dose of ethanol
Morgan, Michael, Holgate, Jan, Hewavitharana, Amitha K., Shaw, Nick, Cabot, Peter and Bartlett, Selena E. (2013). The biotransformation of beta-endorphin in the rat brain after a single sedating dose of ethanol. Australasian Professional Society on Alcohol and other Drugs Conference, Brisbane, QLD, Australia, 24-27 November 2013. Chichester, West Sussex, United Kingdom: Wiley-Blackwell. doi: 10.1111/dar.12077
Hewavitharana, Amitha K. (2012). Dependence of secondary metabolite profiles of Salinispora species on their geographical distribution. 16th International Congress (PHYTOPHARM 2012), St Petersburg, Russia, 9-11 July 2012.
Bose, Utpal, Vidgen, Miranda, Shaw, Nick, Fuerst, John A. and Hewavitharana, Amitha (2011). Application of HPLC_QTOF-MS/MS to assess the chemical diversity of the marine actinobacterial genus Salinispora. Australian Pharmaceutical Science Association Conference, Adelaide, Australia, 2011.
Ng,Yi Kai, Hewavitharana, Amitha, Shaw, Paul N., Webb, Richard, Hooper, John and Fuerst, John A. (2011). Developmental cycle and antibiotic production of Salinispora arenicola isolated from Great Barrier Reef Marine sponges. Society for General Microbiology Autumn Conference 2011, York, United Kingdom, 5-7 September 2011.
Bala, Neeraj, Aitken, Elizabeth A.B., Hewavitharana, Amitha, Ross, Benjamin and Steadman, Kathryn (2011). Identification of antimicrobial compounds in the crude extracts of the Australian macrofungi, Hohenbuehelia sp. and Ramaria sp., through bioassay-guided fractionation. Australian Pharmaceutical Science Association Conference, Adelaide, Australia, 11-14 December 2011.
Herath, Dilanthi, Hewavitharana, Amitha K., Cabot, Peter J. and Shaw, P. Nicholas (2011). Identification of enzyme-sensitive cleavage sites of beta endorphin (beta- END) using serum and inflamed tissue. American Peptide Symposium (22nd, 2011), San Diego, CA, U.S.A., 25-30 June 2011. Hoboken, NJ, U.S.A.: John Wiley & Sons. doi: 10.1002/bip.21670
Salinispora, Planctomycetes and their implications for sponge microbiology
Fuerst, John A., Hewavitharana, Amitha, Hooper, John, Izumi, Hiroshi, Ng, Yi Kai, Sagulenko, Evgeny, Shaw, Paul N., Schirra, Horst and Vidgen, Miranda (2011). Salinispora, Planctomycetes and their implications for sponge microbiology. 1st International sponge microbiology conference, Germany, 2011.
Mutalik, Srinivas, Parekh, Harendra S., Hewavitharana, Amitha K., Shaw, P. Nick, Anissimov, Yuri G. and Roberts, Michael S. (2008). Development and validation of RP-HPLC method for quantification of peptide dendrimers in skin permeation experiments. Australian Pharmaceutical Science Association Conference 2008, Canberra, ACT Australia, 6-9 December 2008.
Hewavitharana, A, Shaw, P N, Kim, T. K. and Fuerst, J A (2006). Assessment of the presence of Rifamycin antibiotics in marine sponge bacterium Salinispora using LC-MS-MS. INTERACT 2006: Air, Water and Earth: INTERACT in Perth, Perth, Australia, 24-28 September 2006. Canning Bridge, Australia: Promaco Conventions.
Identification and quantitation of intact beta-endorphin by LC-MS-MS
Cabot, P. J., Hewavitharana, A., Pham, U. and Shaw, P. N. (2006). Identification and quantitation of intact beta-endorphin by LC-MS-MS. BPC Science: British Pharmaceutical Conference, Manchester UK / Manchester International Convention Centre, 4-6 September 2006. West Sussex, U.K.: John Wiley & Sons. doi: 10.1211/002235706778251393
Increased acetaminophen hepatotoxicity in the NaS1 and Sat1 sulfate transporter null mice
Lee, S, Dawson, P A, Hewavitharana, A, Shaw, P N and Markovich, D (2006). Increased acetaminophen hepatotoxicity in the NaS1 and Sat1 sulfate transporter null mice. ComBio2006, Brisbane / Brisbane Convention Centre, 24-28 September 2006. Brisbane: Australian Physiological Society.
Nutritional bioactives in tropical fruit
Wilkinson, A, Hewavitharana, A, Flanagan, B M, Dietzgen, R G, Monteith, G R, Shaw, P N, Roberts-Thomson, S J and Gidley, M (2006). Nutritional bioactives in tropical fruit. The 3rd Australian Health & Medical Research Congress, Melbourne Convention Centre, Melbourne, Australia, 26 November-1 December, 2006. Melbourne, Vic, Australia: National Health and Medical Research Council.
Profiling acetaminophen metabolites in mouse urine by LC-MS-MS
Shaw, P N, Hewavitharana, A, Lee, S, Dawson, P A and Markovich, D (2006). Profiling acetaminophen metabolites in mouse urine by LC-MS-MS. British Pharmaceutical Conference, Manchester UK / Mancester International Convention Centre, 4-6 September 2006. Belfast, Northern Ireland: Pharmaceutical Press.
Profiling acetaminophen metabolites in mouse urine by LC-MS-MS
Shaw, P. N., Hewavitharana, A. K., Lee, S., Dawson, P. and Markovich, D. (2006). Profiling acetaminophen metabolites in mouse urine by LC-MS-MS. The British Pharmaceutical Conference, Manchester, England, 4-6 September 2006. West Sussex, England, U.K.: John Wiley & Sons Ltd.. doi: 10.1211/002235706778251375
Sutherland, A., Hewavitharana, A., Flanagan, B. M., Monteith, G. R., Shaw, N., Roberts-Thomson, S. J. and Gidley, M. (2005). Development and application of a liposome delivery method to enhance the bioavailability of antioxidants and evaluate cytotoxicity in colon and breast cancer in vitro models. 29th Annual Scientific Meeting of Nutrition Society of Australia, Melbourne, Vic, Australia, 30 November-3 December, 2005. Clayton, Vic., Australia: Blackwell Science Asia.
Effect of drug-protein interactions on drug assay
Hewavitharana, A., Shaw, N., Hyde, C. and Thomas, R. (2005). Effect of drug-protein interactions on drug assay. Joint Meeting of ASCEPT and APSA, Melbourne, Australia, 4-7 December 2005. Australia: Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists.
Hewavitharana, A. and Shaw, N. (2005). Manipulation of the population of non-covalently bound species formed in the electrospray interface of LC-MS. Australian & New Zealand Society for Mass Spectrometry - 20th Conference, Adelaide, Australia, 30 Jan. - 3 Feb. 2005. Australia:
A Feasibility Study of Fingerprinting Alcoholic Spirits Using SPME-GC-MS
Hewavitharana, A. K., Christensen, E., Golding, G. and Scheelings, P. (2004). A Feasibility Study of Fingerprinting Alcoholic Spirits Using SPME-GC-MS. Interact 2004, Gold Coast, Queensland, Australia, 4-8 July 2004.
Analysis of chicken meat for the influence of diet on tocopherol and tocotrienol compositions
Hewavitharana, A. K., Lanari, M.C. and Becu, C. U. (2003). Analysis of chicken meat for the influence of diet on tocopherol and tocotrienol compositions. 49th International Congress of Meat Science and Technology, Sao Paulo, Brazil, 31st August - 5th September 2003. Sao Paulo, Brazil: ICoMST.
Developing a method for measuring thiopurine drug and metabolites
(2018) Research Donation Generic
(2010) UQ Major Equipment and Infrastructure
Note for students: Dr Amitha Hewavitharana is not currently available to take on new students.
Investigation of Selective Anti-Proliferative and Immunomodulatory Properties of Carica Papaya
(2017) Doctor Philosophy — Principal Advisor
Other advisors:
Development of an assay for total vitamin D content in milk and application to study the effect of pasteurisation in breastmilk
(2016) Doctor Philosophy — Principal Advisor
Other advisors:
Investigation of bioactive compounds with anti-cancer potential in Carica papaya leaves
(2016) Doctor Philosophy — Principal Advisor
Other advisors:
(2014) Doctor Philosophy — Principal Advisor
Other advisors:
A study of the activity and efficacy of beta endorphin fragments in inflamed tissue
(2013) Doctor Philosophy — Principal Advisor
Other advisors:
Development of an assay for vitamin D in biological samples
(2018) Doctor Philosophy — Associate Advisor
Other advisors:
Essential Trace Element Analysis of Human Breast Milk
(2017) Doctor Philosophy — Associate Advisor
Other advisors:
Beta-Endorphin Biotransformation and Modulation of Inflammatory Signals
(2015) Doctor Philosophy — Associate Advisor
Other advisors:
(2013) Doctor Philosophy — Associate Advisor
Other advisors:
Genetic and chemical diversity of the actinobacterial genus Salinispora isolated from Great Barrier Reef sponges.
(2012) Doctor Philosophy — Associate Advisor
Other advisors:
(2010) Doctor Philosophy — Associate Advisor
Other advisors: