Dr Julie Davies

Honorary Research Fellow

Mater Research Institute-UQ
Faculty of Medicine

Overview

Publications

  • Mann, Zoya, Lim, Fayth, Verma, Suzie, Nanavati, Bageshri N., Davies, Julie M., Begun, Jakob, Hardeman, Edna C., Gunning, Peter W., Subramanyam, Deepa, Yap, Alpha S. and Duszyc, Kinga (2023). Pre-existing tissue mechanical hypertension at adherens junctions disrupts apoptotic extrusion in epithelia. Molecular Biology of the Cell, 35 (1), br3. doi: 10.1091/mbc.e23-08-0337

  • McGuckin, Michael A., Davies, Julie M., Felgner, Pascal, Wong, Kuan Yau, Giri, Rabina, He, Yaowu, Moniruzzaman, Md., Kryza, Thomas, Sajiir, Haressh, Hooper, John D., Florin, Timothy H., Begun, Jakob, Oussalah, Abderrahim, Hasnain, Sumaira Z., Hensel, Michael and Sheng, Yong H. (2023). MUC13 cell surface mucin limits Salmonella Typhimurium infection by protecting the mucosal epithelial barrier. Cellular and Molecular Gastroenterology and Hepatology, 16 (6), 985-1009. doi: 10.1016/j.jcmgh.2023.08.011

  • Alabbas, Saleh Y., Giri, Rabina, Oancea, Iulia, Davies, Julie, Schreibner, Veronika, Florin, Timothy H. and Begun, Jakob (2023). Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liver. Journal of Gastroenterology and Hepatology, 38 (4), 609-618. doi: 10.1111/jgh.16102

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Grants

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Publications

Book Chapter

  • Dheer, Rishu, Davies, Julie M. and Abreu, Maria T. (2015). Inflammation and colorectal cancer. Intestinal tumorigenesis: mechanisms of development & progression. (pp. 211-256) edited by Vincent W. Yang and Agnieszka B. Bialkowska. Cham, Switzerland: Springer. doi: 10.1007/978-3-319-19986-3_8

Journal Article

Conference Publication

  • Sheng, Yong H., Giri, Rabina, Davies, Julie, Schreiber, Veronika, Alabbas, Saleh Y., He, Yaowu, Wu, Andy, Hooper, John, Oancea, Iulia, Kijanka, Gregor, Hasnain, Sumaira Z., McGuckin, Michael, Florin, Timothy H. and Begun, Jakob (2020). Thioguanine inhibits colorectal tumorigenesis via β-catenin signalling in intestinal epithelial cells independently of immunosuppression or autophagy. DDW 2020, Online, 2-5 May 2020. Philadelphia, PA United States: Elsevier . doi: 10.1016/s0016-5085(20)30856-8

  • Morata, Cynthia, Picon-Ruiz, Manuel, Davies, Julie, Qureshi, Rehana, Burgueno, Juan F., Abreu, Maria T. and Slingerland, Joyce (2018). Dual role of TLR4 in colorectal tumorigenesis in obesitymediated inflammation in vivo. In: , , (S-649-S-649). . doi:10.1016/s0016-5085(18)32311-4

  • Davies, Julie, Diaz, Sophia, Quintero, Maria A., Czul, Frank, Santaolalla, Rebeca, Dheer, Rishu, Burgueno, Juan F., Guevara, Patricia L., Opiela, Shannon J., Deshpande, Amar, Kerman, David H., Damas, Oriana M., Sundrud, Mark and Abreu, Maria T. (2017). Characterization of Immune Phenotypes as Predictive Biomarkers for Response to Vedolizumab. Digestive Disease Week (DDW) 2017, Chicago, IL United States, 6-9 May 2017. PHILADELPHIA: Elsevier. doi: 10.1016/s0016-5085(17)32170-4

  • Phillips, Matthew C., Dheer, Rishu, Santaolalla, Rebeca, Davies, Julie, Burgueno, Juan F., Lang, Jessica K., Toborek, Michal and Abreu, Maria T. (2017). Genotoxic Effects of PCB 153 Cause NF-KB Dependent Increases in Intestinal Permeability and Intestinal Inflammation via the ATM/NEMO Pathway. Digestive Disease Week (DDW) 2017, Chicago, IL United States, 6-9 May 2017. PHILADELPHIA: Elsevier. doi: 10.1016/s0016-5085(17)33272-9

  • Burgueno, Juan F., Fernández, Irina, Diaz, Sophia, Phillips, Matthew C., Santander, Ana M., Davies, Julie, Santaolalla, Rebeca, Dheer, Rishu and Abreu, Maria T. (2017). TLR4-Driven Tumorigenesis is Associated with an Expansion of Intestinal Stem Cells. Digestive Disease Week (DDW) 2017, Chicago, IL United States, 6-9 May 2017. PHILADELPHIA: Elsevier BV. doi: 10.1016/s0016-5085(17)30440-7

  • Dheer, Rishu, Davies, Julie, Quintero, Maria A., Santaolalla, Rebeca, Deshpande, Amar, Kerman, David and Abreu, Maria T. (2016). Analysis of the microbiome and metabolic pathways reveal differences between mucosa and lamina propria surfaces in IBD patients. DDW 2016 Digestive Disease Week, San Diego, CA United States, 21-24 May 2016. Philadelphia, PA United States: Elsevier. doi: 10.1016/s0016-5085(16)32009-1

  • Diaz, Sophia, Davies, Julie, Santaolalla, Rebeca, Dheer, Rishu, Quintero, Maria A., Deshpande, Amar, Kerman, David, Damas, Oriana M., Sundrud, Mark and Abreu, Maria T. (2016). A Translational Study Characterizing the T-cell Signatures of IBD Patients Responding to Vedolizumab, an α4β7 Integrin Blocker. Digestive Disease Week (DDW) 2016, San Diego, CA United States, 21 - 24 May 2016. PHILADELPHIA: Elsevier. doi: 10.1016/s0016-5085(16)30291-8

  • Diaz, Sophia, Davies, Julie, Santaolalla, Rebeca, Dheer, Rishu, Lang, Jessica, Phillips, Matthew and Abreu, Maria (2016). Characterization of Primary Colonic Stem Cells in a Murine Model of Colitis-Associated Cancer. Advances in Inflammatory Bowel Diseases Crohn's and Colitis Foundation's National Clinical and Research Conference, Orlando, FL, United States, 10-12 December 2015. Philadelphia, PA, United States: Lippincott Williams & Wilkins. doi: 10.1097/01.mib.0000480299.71348.c9

  • Phillips, Matthew C., Dheer, Rishu, Davies, Julie, Santaolalla, Rebeca, Lang, Jessica K. and Abreu, Maria T. (2016). Inflammatory Effects of Polychlorinated Biphenyls: Effects on Intestinal Epithelial Cells and Gut Microbiome. Digestive Disease Week (DDW) 2016, San Diego, CA United States, 21 - 24 May 2016. PHILADELPHIA: Elsevier. doi: 10.1016/s0016-5085(16)31321-x

  • Phillips, Matthew, Dheer, Rishu, Santaolalla, Rebeca, Davies, Julie, Lang, Jessica and Abreu, Maria (2016). Inflammatory Effects of Polychlorinated Biphenyls: Effects on the Intestinal Epithelial Cells and Gut Microbiome. Advances in Inflammatory Bowel Diseases Crohn's and Colitis Foundation's National Clinical and Research Conference, Orlando, FL, United States, 10-12 December 2015. Philadelphia, PA, United States: Lippincott Williams & Wilkins. doi: 10.1097/01.mib.0000480286.31409.ba

  • Dheer, Rishu, Davies, Julie, Quintero, Maria Alejandra, Santaolalla, Rebeca, Deshpande, Amar, Kerman, David, McCauley, Jacob and Abreu, Maria (2016). Mucosal Microbiota that Breach the Intestinal Epithelial Barrier-A Step Towards Identifying Potential Pathogens in IBD. Advances in Inflammatory Bowel Diseases Crohn's and Colitis Foundation's National Clinical and Research Conference, Orlando, FL, United States, 10-12 December 2015. Philadelphia, PA, United States: Lippincott Williams & Wilkins. doi: 10.1097/01.mib.0000480312.66811.0f

  • Lang, Jessica, Santaolalla, Rebeca, Dheer, Rishu, Davies, Julie, Phillips, Matthew, Grant, Jeff, Zaias, Julia and Abreu, Maria (2016). The Effects of Environmental Enrichment, Social Housing and Gender on Intestinal Tumorigenesis in a Murine Model of Colon Cancer. Advances in Inflammatory Bowel Diseases Crohn's and Colitis Foundation's National Clinical and Research Conference, Orlando, FL, United States, 10-12 December 2015. Philadelphia, PA, United States: Lippincott Williams & Wilkins. doi: 10.1097/01.mib.0000480277.60118.38

  • Winkler, Ingrid G., Barbier, Valerie, Ward, Micheal, Tallack, Michael, Lowe, Jessica, Davies, Julie, Erbani, Johanna, Magnani, John L. and Levesque, Jean-Pierre (2016). Vascular E-Selectin Protects Leukemia Cells from Chemotherapy By Directly Activating Pro-Survival NF-Kb Signalling - Therapeutic Blockade of E-Selectin Dampens NF-Kb Activation. 58th Annual Meeting and Exposition of the American Society of Hematology (ASH), San Diego, CA, United States, 3-6 December 2016. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood.v128.22.2823.2823

  • Winkler, Ingrid G., Barbier, Valerie, Radford, Kristen J., Davies, Julie M., Levesque, Jean-Pierre, Smith, Theodore A. G., Fogler, William E. and Magnani, John L. (2015). Mobilization of CD8(+) Central Memory T-Cells with Enhanced Reconstitution Potential in Mice By a Combination of G-CSF and GMI-1271-Mediated E-Selectin Blockade. 57th Annual Meeting of the American Society of Hematology, Orlando, FL United States, 5-8 December 2015. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood.V126.23.512.512

  • Davies, Julie M., Santaolalla, Rebeca, von Furstenberg, Richard J., Henning, Susan J. and Abreu, Maria T. (2015). Viral products elicit different phenotypes from small intestine and colonic crypt cultures. In: , , (S-723-S-723). . doi:10.1016/s0016-5085(15)32465-3

  • Santaolalla, Rebeca, Davies, Julie, Dheer, Rishu, Lang, Jessica and Abreu, Maria (2014). Interleukin-1 receptor-associated kinases are key in TLR4-mediated activation of B-catenin. 2014 Advances in Inflammatory Bowel Diseases Crohn's and Colitis Foundation's National Clinical and Research Conference, Orlando, FL, United States, 4-6 December 2014. New York, United States: Oxford University Press . doi: 10.1097/01.mib.0000456893.54364.1a

  • Dheer, Rishu, Davies, Julie, Santaolalla, Rebeca, Lang, Jessica and Abreu, Maria (2014). Intestinal epithelium specific TLR4 over-expression causes transmissible colitis via microbial dysbiosis. In: 2014 Advances in Inflammatory Bowel Diseases Crohn's and Colitis Foundation's National Clinical and Research Conference, Orlando, FL, United States, (S15-S15). 4-6 December 2014. doi:10.1097/01.mib.0000456684.04031.60

  • Davies, Julie M., Dheer, Rishu, Hua, Hong-Uyen, Martinez, Mitchell, Bhattacharya, Sanjoy K. and Abreu, Maria T. (2014). Stool Phospholipids and the Microbiota: Using Mass Spectrometry and Microbial Profiling to Generate Disease-Specific Signatures. Digestive Disease Week (DDW) 2014, Chicago, IL United States, May 2014. Elsevier. doi: 10.1016/s0016-5085(14)60498-4

  • Davies, Julie M., Santaolalla, Rebeca and Abreu, Maria T. (2014). TLR Signaling Alters Growth and Differentiation of Colonoids: Evidence for Innate Immune Signaling in Stem Cell Biology. Digestive Disease Week (DDW) 2014, Chicago, IL United States, May 2014. PHILADELPHIA: Elsevier. doi: 10.1016/s0016-5085(14)61867-9

  • Dheer, Rishu, Davies, Julie M., Santaolalla, Rebeca, Fukata, Masayuki, Lang, Jessica K. and Abreu, Maria T. (2014). TLR4 Overexpression in the Intestinal Epithelium Disturbs Microbial Segregation and Intestinal Homeostasis. Digestive Disease Week (DDW) 2014, Chicago, IL United States, May 2014. PHILADELPHIA: Elsevier. doi: 10.1016/s0016-5085(14)63042-0

  • Davies, Julie, Hua, Hong-Uyen, Martinez, Mitchell, Dheer, Rishu, Bhattacharya, Sanjoy and Abreu, Maria (2013). Lipid signatures in stool: the effect of colitis-associated tumorigenesis and a high fat diet on phospholipid profiles. In: 2013 Advances in Inflammatory Bowel Diseases Crohn's and Colitis Foundation's National Clinical and Research Conference, Hollywood, FL, United States, (S107-S108). 12-14 December 2013. doi:10.1097/01.mib.0000439005.92435.38

  • Davies, Julie M., Santaolalla, Rebeca, Dheer, Rishu, Lang, Jessica K. and Abreu, Maria T. (2013). Obesity Induces Colonic and Mesenteric Fat Inflammation and Promotes Tumorigenesis in a Model of Murine Colon Cancer. Digestive Disease Week (DDW) 2013, Orlando, FL United States, 2013. Elsevier. doi: 10.1016/s0016-5085(13)60455-2

  • Dheer, Rishu, Santaolalla, Rebeca, Davies, Julie, Pastorini, Cristhine, Fukata, Masayuki and Abreu, Maria (2013). TLR4 regulates intestinal bacterial populations and stem cell dynamics. In: 2013 Advances in Inflammatory Bowel Diseases Crohn's and Colitis Foundation's National Clinical and Research Conference, Hollywood, FL, United States, (S121-S121). 12-14 December 2013. doi:10.1097/01.mib.0000439036.26090.96

  • Santaolalla, Rebeca, Davies, Julie, Dheer, Rishu, Lang, Jessica and Abreu, Maria (2013). TLR4 signaling in the intestinal epithelium is associated with the expression of S100A8 in colitis-associated cancer. Advances in Inflammatory Bowel Diseases Crohn's and Colitis Foundation's National Clinical and Research Conference, Hollywood, FL, United States, 12-14 December 2013. New York, United States: Oxford University Press . doi: 10.1097/01.mib.0000439021.67779.f5

  • Santaolalla, Rebeca, Davies, Julie M., Ruiz, Jose, Espana, Cecilia, Fukata, Masayuki and Abreu, Maria T. (2012). 175 TLR4 Activates LGR5 Expression in the Colon: A Link Between Cancer Stem Cells and Innate Immune Signals. Digestive Disease Week (DDW) 2012, San Diego, CA United States, 19 - 22 May 2012. PHILADELPHIA: Elsevier. doi: 10.1016/s0016-5085(12)60164-4

  • Dheer, Rishu, Davies, Julie, Strobel, Sebastian, Santaolalla, Rebeca, Espana, Cecilia and Abreu, Maria (2012). Distinct Inflammatory Pathways Induce Altered Intracellular Bacterial Community in Murine Colonic Lamina Propria Macrophages. Crohn's-and-Colitis-Foundation's-National-Clinical-and-Research Conference on Advances in Inflammatory Bowel Diseases, Hollywood, FL, United States, 13-15 December 2012. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1097/00054725-201212001-00297

  • Ambrose, Monica, Moloney, Gerard, Heuston, Sinead, Rahman, Arman, Davies, Julie M., Murphy, Carola, Hurley, Grainne, Quinlan, Aoife, Karras, Jim, Hessel, Edith M., Prinjha, Rab, Lee, Kevin, Hyland, Niall P., Shanahan, Fergus, Hammarstrom, Marie-Louise, Melgar, Silvia and Nally, Kenneth (2012). MiR-375 is a Key Regulator of Intestinal Homeostasis in Response to Inflammatory Stress. Digestive Disease Week (DDW) 2012, San Diego, CA United States, 19 - 22 May 2012. Elsevier. doi: 10.1016/s0016-5085(12)61305-5

  • Santaolalla, Rebeca, Ruiz, Jose, Davies, Julie, Sussman, Daniel, Pastorini, Cristhine, Espana, Cecilia, Burlingame, Oname, Bejarano, Pablo, Rassaei, Negar, Ko, Jeffrey, Dirisina, Ramanarao, Barrett, Terrence, Shang, Limin, Lira, Sergio, Fukata, Masayuki and Abreu, Maria (2012). TLR4 Activates the B-Catenin Pathway to Cause Intestinal Neoplasia. Crohn's-and-Colitis-Foundation's-National-Clinical-and-Research Conference on Advances in Inflammatory Bowel Diseases, Hollywood, FL, United States, 13-15 December 2012. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1097/00054725-201212001-00032

  • Santaolalla, Rebeca, Ruiz, Jose, Davies, Julie, Sussman, Daniel, Pastorini, Cristhine, Espana, Cecilia, Burlingame, Oname, Bejarano, Pablo, Rassaei, Negar, Ko, Jeffrey, Dirisina, Ramanarao, Barrett, Terrence, Shang, Limin, Lira, Sergio, Fukata, Masayuki and Abreu, Maria (2012). TLR4 Activates the B-Catenin Pathway to Cause Intestinal Neoplasia. Crohn's-and-Colitis-Foundation's-National-Clinical-and-Research Conference on Advances in Inflammatory Bowel Diseases, Hollywood, FL, United States , 13-15 December 2012. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1097/00054725-201212001-00280

  • Davies, Julie, Santaolalla, Rebeca and Abreu, Maria (2012). TLR4 Signaling Alters Intestinal Epithelial Cell Differentiation and the Stem Cell Niche. Crohn's-and-Colitis-Foundation's-National-Clinical-and-Research Conference on Advances in Inflammatory Bowel Diseases, Hollywood, FL, United States, 13-15 December 2012. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1097/00054725-201212001-00255

  • Davies, Julie, Santaolalla, Rebeca and Abreu, Maria (2012). TLR4 Signaling Alters Intestinal Epithelial Cell Differentiation and the Stem Cell Niche. Crohn's-and-Colitis-Foundation's-National-Clinical-and-Research Conference on Advances in Inflammatory Bowel Diseases, Hollywood, FL, United States, 13-15 December 2012. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1097/00054725-201212001-00029

  • Santaolalla, R., Ruiz, J., Fukata, M., España, C., Davies, J. M., Pastorini, C., Sussman, D. A., Ko, J., Dirisina, R., Barrett, T. A. and Abreu, M. T. (2012). TLR4 signaling activates the Wnt pathway in a mouse model of colitis-associated neoplasia. 7th Congress of ECCO, Barcelona, Spain , 16-18 February 2012. Oxford, United Kingdom: Oxford University Press . doi: 10.1016/s1873-9946(12)60014-2

  • Davies, Julie M., MacSharry, John and Shanahan, Fergus (2010). Functionally Distinct LPS Responses in Peyer's Patch and Spleen Dendritic Cells are Underpinned by Differential TLR Regulation. Digestive Disease Week (DDW) 2010, New Orleans, United States, 1-5 May 2010. PHILADELPHIA: Elsevier. doi: 10.1016/s0016-5085(10)61235-8

  • Davies, Julie M., Sheil, Barbara and Shanahan, Fergus (2009). Enteric Bacterial Signalling Overrides Cytokine Signalling and Modifies Dendritic Cell Differentiation. In: Digestive Disease Week (DDW) 2009, Chicago, IL, United States, (A-706-A-707). 30 May-4 June 2009. doi:10.1016/s0016-5085(09)63258-3

Grants (Administered at UQ)