The University of Queensland

CaMKII mediates sexually dimorphic synaptic transmission at neuromuscular junctions in C. elegans

Zeng, Wan-Xin, Liu, Haowen, Hao, Yue, Qian, Kang-Ying, Tian, Fu-Min, Li, Lei, Yu, Bin, Zeng, Xian-Ting, Gao, Shangbang, Hu, Zhitao and Tong, Xia-Jing (2023). CaMKII mediates sexually dimorphic synaptic transmission at neuromuscular junctions in C. elegans. Journal of Cell Biology, 222 (11) e202301117. doi: 10.1083/jcb.202301117

UNC-43/CaMKII-triggered anterograde signals recruit GABAARs to mediate inhibitory synaptic transmission and plasticity at C. elegans NMJs

Hao, Yue, Liu, Haowen, Zeng, Xian-Ting, Wang, Ya, Zeng, Wan-Xin, Qian, Kang-Ying, Li, Lei, Chi, Ming-Xuan, Gao, Shangbang, Hu, Zhitao and Tong, Xia-Jing (2023). UNC-43/CaMKII-triggered anterograde signals recruit GABAARs to mediate inhibitory synaptic transmission and plasticity at C. elegans NMJs. Nature Communications, 14 (1) 1436, 1-15. doi: 10.1038/s41467-023-37137-0

The C2 and PH domains of CAPS constitute an effective PI(4,5)P2-binding unit essential for Ca2+-regulated exocytosis

Zhang, Li, Li, Lei, Wei, Ziqing, Zhou, Hao, Liu, Haowen, Wang, Shen, Ren, Yijing, Dai, Tiankai, Wang, Jiafan, Hu, Zhitao and Ma, Cong (2023). The C2 and PH domains of CAPS constitute an effective PI(4,5)P2-binding unit essential for Ca2+-regulated exocytosis. Structure, 31 (4), 424-434.e6. doi: 10.1016/j.str.2023.02.004

CASK and FARP localize two classes of post-synaptic ACh receptors thereby promoting cholinergic transmission

Li, Lei, Liu, Haowen, Qian, Kang-Ying, Nurrish, Stephen, Zeng, Xian-Ting, Zeng, Wan-Xin, Wang, Jiafan, Kaplan, Joshua M., Tong, Xia-Jing and Hu, Zhitao (2022). CASK and FARP localize two classes of post-synaptic ACh receptors thereby promoting cholinergic transmission. PLoS Genetics, 18 (10) e1010211, e1010211. doi: 10.1371/journal.pgen.1010211

Protocols for electrophysiological recordings and electron microscopy at C. elegans neuromuscular junction

Liu, Haowen, Li, Lei, Krout, Mia, Sheoran, Seema, Zhao, Qihong, Chen, Jingyi, Liu, Huisheng, Richmond, Janet E. and Hu, Zhitao (2021). Protocols for electrophysiological recordings and electron microscopy at C. elegans neuromuscular junction. STAR Protocols, 2 (3) 100749, 1-21. doi: 10.1016/j.xpro.2021.100749

The M domain in UNC-13 regulates the probability of neurotransmitter release

Liu, Haowen, Li, Lei, Sheoran, Seema, Yu, Yi, Richmond, Janet E., Xia, Jingyao, Tang, Jing, Liu, Jie and Hu, Zhitao (2021). The M domain in UNC-13 regulates the probability of neurotransmitter release. Cell Reports, 34 (10) 108828. doi: 10.1016/j.celrep.2021.108828

A unique C2 domain at the C terminus of Munc13 promotes synaptic vesicle priming

Padmanarayana, Murugesh, Liu, Haowen, Michelassi, Francesco, Li, Lei, Betensky, Daniel, Dominguez, Matthew J., Sutton, R. Bryan, Hu, Zhitao and Dittman, Jeremy S. (2021). A unique C2 domain at the C terminus of Munc13 promotes synaptic vesicle priming. Proceedings of the National Academy of Sciences, 118 (11) e2016276118, e2016276118. doi: 10.1073/pnas.2016276118

Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner

Qian, Kang-Ying, Zeng, Wan-Xin, Hao, Yue, Zeng, Xian-Ting, Liu, Haowen, Li, Lei, Chen, Lili, Tian, Fu-min, Chang, Cindy, Hall, Qi, Song, Chun-Xue, Gao, Shangbang, Hu, Zhi-Tao, Kaplan, Joshua M., Li, Qian and Tong, Xia-Jing (2021). Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner. eLife, 10 e67170, 1-29. doi: 10.7554/eLife.67170

A novel dual Ca2+ sensor system regulates Ca2+-dependent neurotransmitter release

Li, Lei, Liu, Haowen, Krout, Mia, Richmond, Janet E., Wang, Yu, Bai, Jihong, Weeratunga, Saroja, Collins, Brett M., Ventimiglia, Donovan, Yu, Yi, Xia, Jingyao, Tang, Jing, Liu, Jie and Hu, Zhitao (2021). A novel dual Ca2+ sensor system regulates Ca2+-dependent neurotransmitter release. Journal of Cell Biology, 220 (4) e202008121, 1-24. doi: 10.1083/jcb.202008121

A hyperactive form of unc-13 enhances Ca2+ sensitivity and synaptic vesicle release probability in C. elegans

Li, Lei, Liu, Haowen, Hall, Qi, Wang, Wei, Yu, Yi, Kaplan, Joshua M. and Hu, Zhitao (2019). A hyperactive form of unc-13 enhances Ca2+ sensitivity and synaptic vesicle release probability in C. elegans. Cell Reports, 28 (11), 2979-2995.e4. doi: 10.1016/j.celrep.2019.08.018

mir-234 controls neuropeptide release at the Caenorhabditis elegans neuromuscular junction

Snieckute, Goda, Baltaci, Oguzhan, Liu, Haowen, Li, Lei, Hu, Zhitao and Pocock, Roger (2019). mir-234 controls neuropeptide release at the Caenorhabditis elegans neuromuscular junction. Molecular and Cellular Neuroscience, 98, 70-81. doi: 10.1016/j.mcn.2019.06.001

Heterodimerization of UNC-13/RIM regulates synaptic vesicle release probability but not priming in C. elegans

Liu, Haowen, Li, Lei, Nedelcu, Daniel, Hall, Qi, Zhou, Lijun, Wang, Wei, Yu, Yi, Kaplan, Joshua M. and Hu, Zhitao (2019). Heterodimerization of UNC-13/RIM regulates synaptic vesicle release probability but not priming in C. elegans. eLife, 8 e40585. doi: 10.7554/eLife.40585

The Claudin-like protein HPO-30 is required to maintain LAChRs at the C. elegans neuromuscular junction

Sharma, Pallavi, Li, Lei, Liu, Haowen, Tikiyani, Vina, Hu, Zhitao and Babu, Kavita (2018). The Claudin-like protein HPO-30 is required to maintain LAChRs at the C. elegans neuromuscular junction. The Journal of Neuroscience, 38 (32), 7072-7087. doi: 10.1523/JNEUROSCI.3487-17.2018

SNT-1 functions as the Ca2+ sensor for tonic and evoked neurotransmitter release in Caenorhabditis Elegans

Li, Lei, Liu, Haowen, Wang, Wei, Chandra, Mintu, Collins, Brett M. and Hu, Zhitao (2018). SNT-1 functions as the Ca2+ sensor for tonic and evoked neurotransmitter release in Caenorhabditis Elegans. The Journal of Neuroscience, 38 (23), 5313-5324. doi: 10.1523/JNEUROSCI.3097-17.2018

Spontaneous vesicle fusion is differentially regulated at cholinergic and GABAergic synapses

Liu, Haowen, Li, Lei, Wang, Wei, Gong, Jihong, Yang, Xiaofei and Hu, Zhitao (2018). Spontaneous vesicle fusion is differentially regulated at cholinergic and GABAergic synapses. Cell reports, 22 (9), 2334-2345. doi: 10.1016/j.celrep.2018.02.023

Wnt secretion is regulated by the tetraspan protein HIC-1 through its interaction with Neurabin/NAB-1

Tikiyani, Vina, Li, Lei, Sharma, Pallavi, Liu, Haowen, Hu, Zhitao and Babu, Kavita (2018). Wnt secretion is regulated by the tetraspan protein HIC-1 through its interaction with Neurabin/NAB-1. Cell Reports, 25 (7), 1856-1871.e6. doi: 10.1016/j.celrep.2018.10.053

A C1-C2 module in Munc13 inhibits calcium-dependent neurotransmitter release

Michelassi, Francesco, Liu, Haowen , Hu, Zhitao and Dittman, Jeremy S. (2017). A C1-C2 module in Munc13 inhibits calcium-dependent neurotransmitter release. Neuron, 95 (3), 577-590. doi: 10.1016/j.neuron.2017.07.015

Retrograde synaptic inhibition is mediated by α-neurexin binding to the α2δ subunits of n-type calcium channels

Tong, Xia-Jing, Lopez-Soto, Eduardo Javier, Li, Lei, Liu, Haowen, Nedelcu, Daniel, Lipscombe, Diane, Hu, Zhitao and Kaplan, Joshua M. (2017). Retrograde synaptic inhibition is mediated by α-neurexin binding to the α2δ subunits of n-type calcium channels. Neuron, 95 (2), 326-+. doi: 10.1016/j.neuron.2017.06.018

A C1-C2 Module in MUNC13 Inhibits Calcium-Dependent Neurotransmitter Release

Dittman, Jeremy, Michelassi, Francesco, Liu, Haowen and Hu, Zhitao (2017). A C1-C2 Module in MUNC13 Inhibits Calcium-Dependent Neurotransmitter Release. 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, United States, Feb 15-19, 2014. St. Louis, MO, United States: Cell Press. doi: 10.1016/j.bpj.2016.11.2145