The University of Queensland

Muscle fibre mitochondrial [Ca²⁺] dynamics during Ca²⁺ waves in <i>RYR1</i> gain‐of‐function mouse

Gaglianone, Rhayanna B. and Launikonis, Bradley S. (2024). Muscle fibre mitochondrial [Ca2+] dynamics during Ca2+ waves in RYR1 gain‐of‐function mouse. Acta Physiologica, 240 (3) e14098, e14098. doi: 10.1111/apha.14098

Ryanodine receptor activity and store‐operated Ca ²⁺ entry: critical regulators of Ca ²⁺ content and function in skeletal muscle

Pearce, Luke, Meizoso‐Huesca, Aldo, Seng, Crystal, Lamboley, Cedric R., Singh, Daniel P. and Launikonis, Bradley S. (2023). Ryanodine receptor activity and store‐operated Ca 2+ entry: critical regulators of Ca 2+ content and function in skeletal muscle. The Journal of Physiology, 601 (19), 4183-4202. doi: 10.1113/jp279512

A bivalent remipede toxin promotes calcium release via ryanodine receptor activation

Maxwell, Michael J., Thekkedam, Chris, Lamboley, Cedric, Chin, Yanni K.-Y., Crawford, Theo, Smith, Jennifer J., Liu, Junyu, Jia, Xinying, Vetter, Irina, Laver, Derek R., Launikonis, Bradley S., Dulhunty, Angela, Undheim, Eivind A. B. and Mobli, Mehdi (2023). A bivalent remipede toxin promotes calcium release via ryanodine receptor activation. Nature Communications, 14 (1) 1036, 1-13. doi: 10.1038/s41467-023-36579-w

Evolutionary isolation of ryanodine receptor isoform 1 for muscle-based thermogenesis in mammals

Singh, Daniel P., Pearce, Luke, Choi, Rocky H., Meizoso-Huesca, Aldo, Wette, Stefan G., Scott, John W., Lamboley, Cedric R., Murphy, Robyn M. and Launikonis, Bradley S. (2023). Evolutionary isolation of ryanodine receptor isoform 1 for muscle-based thermogenesis in mammals. Proceedings of the National Academy of Sciences, 120 (4) e2117503120, 1-12. doi: 10.1073/pnas.2117503120

Tiny changes in cytoplasmic [Ca²⁺] cause large changes in mitochondrial Ca²⁺: what are the triggers and functional implications?

Seng, Crystal, Pearce, Luke, Meizoso-Huesca, Aldo, Singh, Daniel P., Murphy, Robyn M., Lamboley, Cedric and Launikonis, Bradley S. (2022). Tiny changes in cytoplasmic [Ca2+] cause large changes in mitochondrial Ca2+: what are the triggers and functional implications?. American Journal of Physiology-Cell Physiology, 323 (4), C1285-C1289. doi: 10.1152/ajpcell.00092.2022

Erratum: Correction: A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers (The Journal of general physiology (2022) 154 9 PII: e20211299404062022c)

Barclay, Christopher J. and Launikonis, Bradley S. (2022). Erratum: Correction: A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers (The Journal of general physiology (2022) 154 9 PII: e20211299404062022c). The Journal of general physiology, 154 (9). doi: 10.1085/jgp.20211299404062022c

A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers

Barclay, Christopher J. and Launikonis, Bradley S. (2022). A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers. Journal of General Physiology, 154 (9) e202112994. doi: 10.1085/jgp.202112994

Ca2+ leak through ryanodine receptor 1 regulates thermogenesis in resting skeletal muscle

Meizoso-Huesca, Aldo, Pearce, Luke, Barclay, Christopher J. and Launikonis, Bradley S. (2022). Ca2+ leak through ryanodine receptor 1 regulates thermogenesis in resting skeletal muscle. Proceedings of the National Academy of Sciences, 119 (4) e2119203119, 1-8. doi: 10.1073/pnas.2119203119

Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening

Zhang, Jingyan, Singh, Daniel P., Ko, Christopher Y., Nikolaienko, Roman, Wong King Yuen, Siobhan M., Schwarz, Jacob A., Treinen, Levy M., Tung, Ching-Chieh, Rožman, Kaja, Svensson, Bengt, Aldrich, Courtney C., Zima, Aleksey V., Thomas, David D., Bers, Donald M., Launikonis, Bradley S., Van Petegem, Filip and Cornea, Razvan L. (2022). Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening. Journal of Biological Chemistry, 298 (1) 101412, 101412. doi: 10.1016/j.jbc.2021.101412

Ryanodine receptor leak triggers fiber Ca2+ redistribution to preserve force and elevate basal metabolism in skeletal muscle

Lamboley, Cedric R., Pearce, Luke, Seng, Crystal, Meizoso-Huesca, Aldo, Singh, Daniel P., Frankish, Barnaby P., Kaura, Vikas, Lo, Harriet P., Ferguson, Charles, Allen, Paul D., Hopkins, Philip M., Parton, Robert G., Murphy, Robyn M., van der Poel, Chris, Barclay, Christopher J. and Launikonis, Bradley S. (2021). Ryanodine receptor leak triggers fiber Ca2+ redistribution to preserve force and elevate basal metabolism in skeletal muscle. Science Advances, 7 (44) eabi7166, 1-15. doi: 10.1126/sciadv.abi7166

The Orai1 inhibitor BTP2 has multiple effects on Ca2+ handling in skeletal muscle

Meizoso-Huesca, Aldo and Launikonis, Bradley S. (2021). The Orai1 inhibitor BTP2 has multiple effects on Ca2+ handling in skeletal muscle. Journal of General Physiology, 153 (1) e202012747, 1-12. doi: 10.1085/jgp.202012747

Phasic store-operated Ca2+ entry during excitation-contraction coupling in skeletal muscle fibers from exercised mice

Lilliu, Elena, Hilber, Karlheinz, Launikonis, Bradley S. and Koenig, Xaver (2020). Phasic store-operated Ca2+ entry during excitation-contraction coupling in skeletal muscle fibers from exercised mice. Frontiers in Physiology, 11 597647, 1-11. doi: 10.3389/fphys.2020.597647

A chloride channel blocker prevents the suppression by inorganic phosphate of the cytosolic calcium signals that control muscle contraction

Ferreira, Juan J., Pequera, Germán, Launikonis, Bradley S., Ríos, Eduardo and Brum, Gustavo (2020). A chloride channel blocker prevents the suppression by inorganic phosphate of the cytosolic calcium signals that control muscle contraction. The Journal of Physiology, 599 (1) JP279917, 157-170. doi: 10.1113/jp279917

Multi-species transcriptomics reveals evolutionary diversity in the mechanisms regulating shrimp tail muscle excitation-contraction coupling

Huerlimann, Roger, Maes, Gregory E., Maxwell, Michael J., Mobli, Mehdi, Launikonis, Bradley S., Jerry, Dean R. and Wade, Nicholas M. (2020). Multi-species transcriptomics reveals evolutionary diversity in the mechanisms regulating shrimp tail muscle excitation-contraction coupling. Gene, 752 144765, 144765. doi: 10.1016/j.gene.2020.144765

RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays

Rebbeck, Robyn T., Singh, Daniel P., Janicek, Kevyn A., Bers, Donald M., Thomas, David D., Launikonis, Bradley S. and Cornea, Razvan L. (2020). RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays. Scientific Reports, 10 (1) 1791, 1791. doi: 10.1038/s41598-020-58461-1

A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions

Azimi, Iman, Stevenson, Ralph J., Zhang, Xuexin, Meizoso-Huesca, Aldo, Xin, Ping, Johnson, Martin, Flanagan, Jack U., Chalmers, Silke B., Yoast, Ryan E., Kapure, Jeevak S., Ross, Benjamin P., Vetter, Irina, Ashton, Mark R., Launikonis, Bradley S., Denny, William A., Trebak, Mohamed and Monteith, Gregory R. (2020). A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions. ACS Pharmacology and Translational Science, 3 (1) acsptsci.9b00081, 135-147. doi: 10.1021/acsptsci.9b00081

Components of activation heat in skeletal muscle

Barclay, C. J. and Launikonis, B. S. (2019). Components of activation heat in skeletal muscle. Journal of Muscle Research and Cell Motility, 42 (1), 1-16. doi: 10.1007/s10974-019-09547-5

Mechanistic insights into store-operated Ca 2+ entry during excitation-contraction coupling in skeletal muscle

Koenig, Xaver, Choi, Rocky H., Schicker, Klaus, Singh, Daniel P., Hilber, Karlheinz and Launikonis, Bradley S. (2019). Mechanistic insights into store-operated Ca 2+ entry during excitation-contraction coupling in skeletal muscle. Biochimica et Biophysica Acta, 1866 (7), 1239-1248. doi: 10.1016/j.bbamcr.2019.02.014

Junctional membrane Ca dynamics in human muscle fibers are altered by malignant hyperthermia causative RyR mutation

Cully, Tanya R., Choi, Rocky H., Bjorksten, Andrew R., Stephenson, D. George, Murphy, Robyn M. and Launikonis, Bradley S. (2018). Junctional membrane Ca dynamics in human muscle fibers are altered by malignant hyperthermia causative RyR mutation. Proceedings of the National Academy of Sciences of the United States of America, 115 (32), 201800490-8220. doi: 10.1073/pnas.1800490115

Store-operated Ca2+ entry is activated by every action potential in skeletal muscle

Koenig, Xaver, Choi, Rocky H. and Launikonis, Bradley S. (2018). Store-operated Ca2+ entry is activated by every action potential in skeletal muscle. Communications Biology, 1 (1) 31, 31. doi: 10.1038/s42003-018-0033-7

NHE- and diffusion-dependent proton fluxes across the tubular system membranes of fast-twitch muscle fibers of the rat

Launikonis, Bradley S., Cully, Tanya R., Csernoch, Laszlo and Stephenson, D. George (2018). NHE- and diffusion-dependent proton fluxes across the tubular system membranes of fast-twitch muscle fibers of the rat. The Journal of General Physiology, 150 (1), 95-110. doi: 10.1085/jgp.201711891

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

Mills, Richard J., Titmarsh, Drew M., Koenig, Xaver, Parker, Benjamin L., Ryall, James G., Quaife-Ryan, Gregory A., Voges, Holly K., Hodson, Mark P., Ferguson, Charles, Drowley, Lauren, Plowright, Alleyn T., Needham, Elise J., Wang, Qing-Dong, Gregorevic, Paul, Xin, Mei, Thomas, Walter G., Parton, Robert G., Nielsen, Lars K., Launikonis, Bradley S., James, David E., Elliott, David A., Porrello, Enzo R. and Hudson, James E. (2017). Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest. Proceedings of the National Academy of Sciences of the United States of America, 114 (40), E8372-E8381. doi: 10.1073/pnas.1707316114

Dantrolene requires Mg2+ to arrest malignant hyperthermia

Choi, Rocky H., Koenig, Xaver and Launikonis, Bradley S. (2017). Dantrolene requires Mg2+ to arrest malignant hyperthermia. Proceedings of the National Academy of Sciences of the United States of America, 114 (18), 4811-4815. doi: 10.1073/pnas.1619835114

Doublet stimulation increases Ca2+ binding to troponin C to ensure rapid force development in skeletal muscle

Bakker, Anthony J., Cully, Tanya R., Wingate, Catherine D., Barclay, Christopher J. and Launikonis, Bradley S. (2017). Doublet stimulation increases Ca2+ binding to troponin C to ensure rapid force development in skeletal muscle. Journal of General Physiology, 149 (3), 323-334. doi: 10.1085/jgp.201611727

Human skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise

Cully, Tanya R., Murphy, Robyn M., Roberts, Llion, Raastad, Truls, Fassett, Robert G., Coombes, Jeff S., Jayasinghe, Isuru D. and Launikonis, Bradley S. (2017). Human skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise. Nature Communications, 8 (1) 14266, 14266.1-14266.10. doi: 10.1038/ncomms14266

A quantitative description of tubular system Ca2+ handling in fast- and slow-twitch muscle fibres

Cully, Tanya R., Edwards, Joshua N., Murphy, Robyn M. and Launikonis, Bradley S. (2016). A quantitative description of tubular system Ca2+ handling in fast- and slow-twitch muscle fibres. Journal of Physiology, 594 (11), 2795-2810. doi: 10.1113/JP271658

Leaky ryanodine receptors delay the activation of store overload-induced Ca2+ release, a mechanism underlying malignant hyperthermia-like events in dystrophic muscle

Cully, Tanya R. and Launikonis, Bradley S. (2016). Leaky ryanodine receptors delay the activation of store overload-induced Ca2+ release, a mechanism underlying malignant hyperthermia-like events in dystrophic muscle. American Journal of Physiology: Cell Physiology, 310 (8), C673-C680. doi: 10.1152/ajpcell.00366.2015

Additional in-series compliance reduces muscle force summation and alters the time course of force relaxation during fixed-end contractions

Mayfield, Dean L., Launikonis, Bradley S., Cresswell, Andrew G. and Lichtwark, Glen A. (2016). Additional in-series compliance reduces muscle force summation and alters the time course of force relaxation during fixed-end contractions. Journal of Experimental Biology, 219 (22), 3587-3596. doi: 10.1242/jeb.143123

Activation and propagation of Ca2+ release from inside the sarcoplasmic reticulum network of mammalian skeletal muscle

Cully, Tanya R., Edwards, Joshua N. and Launikonis, Bradley S. (2014). Activation and propagation of Ca2+ release from inside the sarcoplasmic reticulum network of mammalian skeletal muscle. Journal of Physiology, 592 (17), 3727-3746. doi: 10.1113/jphysiol.2014.274274

Observation of the molecular organization of calcium release sites in fast- and slowtwitch skeletal muscle with nanoscale imaging

Jayasinghe, Isuru D., Munro, Michelle, Baddeley, David, Launikonis, Bradley S. and Soeller, Christian (2014). Observation of the molecular organization of calcium release sites in fast- and slowtwitch skeletal muscle with nanoscale imaging. Journal of the Royal Society Interface, 11 (99) 0570, 20140570. doi: 10.1098/rsif.2014.0570

Evidence that collaboration between HIF-1alpha and Notch-1 promotes neuronal cell death in ischemic stroke

Cheng, Yi-Lin, Park, Jong-Sung, Manzanero, Silvia, Choi, Yuri, Baik, Sang-Ha, Okun, Eitan, Gelderblom, Mathias, Fann, David Yang-Wei, Magnus, Tim, Launikonis, Bradley S., Mattson, Mark P., Sobey, Christopher G., Jo, Dong-Gyu and Arumugam, Thiruma V. (2014). Evidence that collaboration between HIF-1alpha and Notch-1 promotes neuronal cell death in ischemic stroke. Neurobiology of Disease, 62, 286-295. doi: 10.1016/j.nbd.2013.10.009

Three-dimensional reconstruction and analysis of the tubular system of vertebrate skeletal muscle

Jayasinghe, Isuru D. and Launikonis, Bradley S. (2013). Three-dimensional reconstruction and analysis of the tubular system of vertebrate skeletal muscle. Journal of Cell Science, 126 (17), 4048-4058. doi: 10.1242/jcs.131565

Examination of the subsarcolemmal tubular system of mammalian skeletal muscle fibers

Jayasinghe, Isuru D., Lo, Harriet P., Morgan, Garry P., Baddeley, David, Parton, Robert G., Soeller, Christian and Launikonis, Bradley S. (2013). Examination of the subsarcolemmal tubular system of mammalian skeletal muscle fibers. Biophysical Journal, 104 (11), L19-L21. doi: 10.1016/j.bpj.2013.04.029

Store-operated Ca2+ entry is not required for store refilling in skeletal muscle

Cully, Tanya R. and Launikonis, Bradley S. (2013). Store-operated Ca2+ entry is not required for store refilling in skeletal muscle. Clinical and Experimental Pharmacology and Physiology, 40 (5), 338-344. doi: 10.1111/1440-1681.12078

Evidence that the EphA2 receptor exacerbates ischemic brain injury

Thundyil, John, Manzanero, Silvia, Pavlovski, Dale, Cully, Tanya R., Lok, Ker-Zhing, Widiapradja, Alexander, Chunduri, Prasad, Jo, Dong-Gyu, Naruse, Chie, Asano, Masahide, Launikonis, Bradley S., Sobey, Christopher G., Coulthard, Mark G. and Arumugam, Thiruma V. (2013). Evidence that the EphA2 receptor exacerbates ischemic brain injury. PLoS One, 8 (1) e53528, e53528.1-e53528.8. doi: 10.1371/journal.pone.0053528

Growth hormone secretagogues preserve the electrophysiological properties of mouse cardiomyocytes isolated from in Vitro ischemia/reperfusion heart

Ma, Yi, Zhang, Lin, Launikonis, Bradley S. and Chen, Chen (2012). Growth hormone secretagogues preserve the electrophysiological properties of mouse cardiomyocytes isolated from in Vitro ischemia/reperfusion heart. Endocrinology, 153 (11), 5480-5490. doi: 10.1210/en.2012-1404

Changes in plasma membrane Ca-ATPase and stromal interacting molecule 1 expression levels for Ca2+ signaling in dystrophic mdx mouse muscle.

Cully, Tanya R., Edwards, Joshua N., Friedrich, Oliver, Stephenson, D. George, Murphy, Robyn M. and Launikonis, Bradley S. (2012). Changes in plasma membrane Ca-ATPase and stromal interacting molecule 1 expression levels for Ca2+ signaling in dystrophic mdx mouse muscle.. American Journal of Physiology - Cell Physiology, 303 (5), C567-C576. doi: 10.1152/ajpcell.00144.2012

Growth hormone secretagogues protect mouse cardiomyocytes from in vitro ischemia/reperfusion injury through regulation of intracellular calcium

Ma, Yi, Zhang, Lin, Edwards, Joshua N., Launikonis, Breadley S. and Chen, Chen (2012). Growth hormone secretagogues protect mouse cardiomyocytes from in vitro ischemia/reperfusion injury through regulation of intracellular calcium. PLoS One, 7 (4) e35265, e35265.1-e35265.9. doi: 10.1371/journal.pone.0035265

Longitudinal and transversal propagation of excitation along the tubular system of rat fast-twitch muscle fibres studied by high speed confocal microscopy

Edwards, Joshua N., Cully, Tanya R., Shannon, Thomas R., Stephenson, D. George and Launikonis, Bradley S. (2012). Longitudinal and transversal propagation of excitation along the tubular system of rat fast-twitch muscle fibres studied by high speed confocal microscopy. Journal of Physiology, 590 (3), 475-491. doi: 10.1113/jphysiol.2011.221796

Store-operated calcium entry remains fully functional in aged mouse skeletal muscle despite a decline in STIM1 protein expression

Edwards, Joshua N., Blackmore, Daniel G., Gilbert, Daniel F., Murphy, Robyn M. and Launikonis, Bradley S. (2011). Store-operated calcium entry remains fully functional in aged mouse skeletal muscle despite a decline in STIM1 protein expression. Aging Cell, 10 (4), 675-685. doi: 10.1111/j.1474-9726.2011.00706.x

Toward the roles of store-operated Ca(2+) entry in skeletal muscle

Launikonis, Bradley S., Murphy, Robyn M. and Edwards, Joshua N. (2010). Toward the roles of store-operated Ca(2+) entry in skeletal muscle. Pflugers Archiv - European Journal of Physiology, 460 (5), 813-823. doi: 10.1007/s00424-010-0856-7

Upregulation of store-operated Ca2+ entry in dystrophic mdx mouse muscle

Edwards, Joshua N., Friedrich, Oliver, Cully, Tanya R., von Wegner, Frederic, Murphy, Robyn M. and Launikonis, Bradley S. (2010). Upregulation of store-operated Ca2+ entry in dystrophic mdx mouse muscle. American Journal of Physiology: Cell Physiology, 299 (1), C42-C50. doi: 10.1152/ajpcell.00524.2009

Ultra-rapid activation and deactivation of store-operated Ca2+ entry in skeletal muscle

Edwards, Joshua N., Murphy, Robyn M., Cully, Tanya R., von Wegner, Frederic, Friedrich, Oliver and Launikonis, Bradley S. (2010). Ultra-rapid activation and deactivation of store-operated Ca2+ entry in skeletal muscle. Cell Calcium, 47 (5), 458-467. doi: 10.1016/j.ceca.2010.04.001

Rapid Ca2+ flux through the transverse tubular membrane, activated by individual action potentials in mammalian skeletal muscle

Launikonis, Bradley S., Stephenson, D. George and Friedrich, Oliver (2009). Rapid Ca2+ flux through the transverse tubular membrane, activated by individual action potentials in mammalian skeletal muscle. Journal of Physiology, 587 (10), 2299-2312. doi: 10.1113/jphysiol.2009.168682

Inhibitory control Over Ca2+ Sparks via Mechanosensitive Channels Is Disrupted in Dystrophin Deficient Muscle but Restored by Mini-Dystrophin Expression

Teichmann, M D H, Wegner, F, Fink, R H A, Chamberlain, J S, Launikonis, B S, Martinac, B and Friedrich, O (2008). Inhibitory control Over Ca2+ Sparks via Mechanosensitive Channels Is Disrupted in Dystrophin Deficient Muscle but Restored by Mini-Dystrophin Expression. PLoS One, 3 (11) e3644, 1-16. doi: 10.1371/journal.pone.0003644

The accessibility and interconnectivity of the tubular system network in toad skeletal muscle

Edwards, Joshua N. and Launikonis, Bradley S. (2008). The accessibility and interconnectivity of the tubular system network in toad skeletal muscle. The Jounal of Physiology, 586 (21), 5077-5089. doi: 10.1113/jphysiol.2008.155127

Calcium-dependent inactivation terminates calcium release in skeletal muscle of amphibians

Rios, E., Zhou, J., Brum, G., Launikonis, B. S. and Stern, M. D. (2008). Calcium-dependent inactivation terminates calcium release in skeletal muscle of amphibians. Journal of General Physiology, 131 (4), 335-348. doi: 10.1085/jgp.200709870

An action potential (AP)-activated Ca2+ current in the tubular system of mammalian skeletal muscle.

Launikonis, B, Stephenson, DG and Rios, E (2007). An action potential (AP)-activated Ca2+ current in the tubular system of mammalian skeletal muscle.. Biophysical Journal, 79A-79A.

Dynamic regulation of the large exocytotic fusion pore in pancreatic acinar cells

Larina, O., Bhat, P., Pickett, J. A., Launikonis, B. S., Shah, A., Kruger, W. A., Edwardson, J. M. and Thorn, P. (2007). Dynamic regulation of the large exocytotic fusion pore in pancreatic acinar cells. Molecular Biology of The Cell, 18 (9), 3502-3511. doi: 10.1091/mbc.E07-01-0024

Store-operated Ca2+ entry during intracellular Ca2+ release in mammalian skeletal muscle

Launikonis, BS and Rios, E (2007). Store-operated Ca2+ entry during intracellular Ca2+ release in mammalian skeletal muscle. Journal of Physiology-london, 583 (1), 81-97. doi: 10.1113/jphysiol.2007.135046

The changes in Ca2+ sparks associated with measured modifications of intra-store Ca2+ concentration in skeletal muscle

Launikonis, Bradley S., Zhou, Jingsong, Santiago, Demetrio, Brum, Gustavo and Rios, Eduardo (2006). The changes in Ca2+ sparks associated with measured modifications of intra-store Ca2+ concentration in skeletal muscle. Journal of General Physiology, 128 (1), 45-54. doi: 10.1085/jgp.200609545

Erratum: A probable role of dihydropyridine receptors in repression of Ca2+ sparks demonstrated in cultured mammalian muscle (American Journal of Physiology - Cell Physiology (539-553) DOI: 10.1152/ajpcell.00592. 2004)

Zhou, J., Yi, J., Royer, L., Launikonis, B. S., González, A., García, J. and Ríos, E. (2006). Erratum: A probable role of dihydropyridine receptors in repression of Ca2+ sparks demonstrated in cultured mammalian muscle (American Journal of Physiology - Cell Physiology (539-553) DOI: 10.1152/ajpcell.00592. 2004). American Journal of Physiology - Cell Physiology, 290 (5) doi: 10.1152/ajpcell.00054.2006

The elusive role of store depletion in the control of intracellular calcium release

Rios, E., Launikonis, B. S., Royer, L., Brum, G. and Zhou, J (2006). The elusive role of store depletion in the control of intracellular calcium release. Journal of Muscle Research And Cell Motility, 27 (5-7), 337-350. doi: 10.1007/s10974-006-9082-5

A probable role of dihydropyridine receptors in repression of Ca2+ sparks demonstrated in cultured mammalian muscle

Zhou, Jingsong, Yi, Jianxun, Royer, Leandro, Launikonis, Bradley S., Gonzalez, Adom, Garcia, Jesus and Rios, Eduardo (2006). A probable role of dihydropyridine receptors in repression of Ca2+ sparks demonstrated in cultured mammalian muscle. American Journal of Physiology - Cell Physiology, 290 (2), C539-C553. doi: 10.1152/ajpcell.00592.2004

Depletion "skraps" and dynamic buffering inside the cellular calcium store

Launikonis, B. S., Zhou, J. S., Royer, L., Shannon, T. R., Brum, G. and Rios, E. (2006). Depletion "skraps" and dynamic buffering inside the cellular calcium store. Proceedings of The National Academy of Sciences of The United States of America, 103 (8), 2982-2987. doi: 10.1073/pnas.0511252103

Concerted vs. sequential. Two activation patterns of vast arrays of intracellular Ca2+ channels in muscle

Zhou, Jin Song, Brum, Gustavo, Gonzalez, Adom, Launikonis, Bradley S., Stern, Michael D. and Rios, Eduardo (2005). Concerted vs. sequential. Two activation patterns of vast arrays of intracellular Ca2+ channels in muscle. Journal of General Physiology, 126 (4), 301-309. doi: 10.1085/jgp.200509353

Confocal imaging of [Ca2+] in cellular organelles by SEER, shifted excitation and emission ratioing of fluorescence

Launikonis, Bradley S., Zhou, Jing Song, Royer, Leandro, Shannon, Thomas R., Brum, Gustavo and Rios, Eduardo (2005). Confocal imaging of [Ca2+] in cellular organelles by SEER, shifted excitation and emission ratioing of fluorescence. Journal of Physiology, 567 (2), 523-543. doi: 10.1113/jphysiol.2005.087973

Regulation of Ca2+ sparks by Ca2+ and Mg2+ in mammalian and amphibian muscle. An RyR isoform-specific role in excitation-contraction coupling?

Zhou, Jingsong, Launikonis, Bradley S., Rios, Eduardo and Brum, Gustavo (2004). Regulation of Ca2+ sparks by Ca2+ and Mg2+ in mammalian and amphibian muscle. An RyR isoform-specific role in excitation-contraction coupling?. Journal of General Physiology, 124 (4), 409-428. doi: 10.1085/jgp.200409105

Osmotic properties of the sealed tubular system of toad and rat skeletal muscle

Launikonis, B. S. and Stephenson, D. G. (2004). Osmotic properties of the sealed tubular system of toad and rat skeletal muscle. Journal of General Physiology, 123 (3), 231-247. doi: 10.1085/jgp.200308946

Ca2+ sparks and embers of mammalian muscle. Properties of the sources

Zhou, Jin Song, Brum, Gustavo, Gonzalez, Adom, Launikonis, Bradley S., Stern, Michael D. and Rios, Eduardo (2003). Ca2+ sparks and embers of mammalian muscle. Properties of the sources. Journal of General Physiology, 122 (1), 95-114. doi: 10.1085/jgp.200308796

Identification of the coupling between skeletal muscle store-operated Ca2+ entry and the inositol trisphosphate receptor

Launikonis, Bradley S., Barnes, Melissa and Stephenson, D. George (2003). Identification of the coupling between skeletal muscle store-operated Ca2+ entry and the inositol trisphosphate receptor. Proceedings of The National Academy of Sciences of The United States of America, 100 (5), 2941-2944. doi: 10.1073/pnas.0536227100

Properties of the vertebrate skeletal muscle tubular system as a sealed compartment

Launikonis, Bradley S. and Stephenson, D. George (2002). Properties of the vertebrate skeletal muscle tubular system as a sealed compartment. Cell Biology International, 26 (10), 921-929. doi: 10.1006/cbir.2002.0942

Tubular system volume changes in twitch fibres from toad and rat skeletal muscle assessed by confocal microscopy

Launikonis, Bradley S. and Stephenson, D. George (2002). Tubular system volume changes in twitch fibres from toad and rat skeletal muscle assessed by confocal microscopy. Journal of Physiology, 538 (2), 607-618. doi: 10.1013/jphysiol.2001.012920

Effects of membrane cholesterol manipulation on excitation-contraction coupling in skeletal muscle of the toad

Launikonis, Bradley S. and Stephenson, D. George (2001). Effects of membrane cholesterol manipulation on excitation-contraction coupling in skeletal muscle of the toad. Journal of Physiology, 534 (1), 71-85. doi: 10.1111/j.1469-7793.2001.00071.x

Cholesterol depletion causes depolarisation of the transverse tubular (t-) system in skeletal muscle fibres from cane toads

Stephenson, DG and Launikonis, B (2001). Cholesterol depletion causes depolarisation of the transverse tubular (t-) system in skeletal muscle fibres from cane toads. Journal of Physiology-london, 533, 127P-128P.

Effects of Mg2+ on Ca2+ release from sarcoplasmic reticulum of skeletal muscle fibres from yabby (crustacean) and rat

Launikonis, Bradley S. and Stephenson, D. George (2000). Effects of Mg2+ on Ca2+ release from sarcoplasmic reticulum of skeletal muscle fibres from yabby (crustacean) and rat. Journal of Physiology, 526 (2), 299-312. doi: 10.1111/j.1469-7793.2000.00299.x

Importance of membrane cholesterol to e-c coupling in toad skeletal muscle

Launikonis, Bradley S. and Stephenson, D. George (2000). Importance of membrane cholesterol to e-c coupling in toad skeletal muscle. Biophysical Journal, 78 (1, Part 2: 44th Annual Meeting), 369A-369A.

Effects of beta-escin and saponin on the transverse-tubular system and sarcoplasmic reticulum membranes of rat and toad skeletal muscle

Launikonis, B. S. and Stephenson, D. G. (1999). Effects of beta-escin and saponin on the transverse-tubular system and sarcoplasmic reticulum membranes of rat and toad skeletal muscle. Pflugers Archiv European Journal of Physiology, 437 (6), 955-965. doi: 10.1007/s004240050867

Effect of saponin treatment on the sarcoplasmic reticulum of rat, cane toad and crustacean (yabby) skeletal muscle

Launikonis, Bradley S. and Stephenson, D. George (1997). Effect of saponin treatment on the sarcoplasmic reticulum of rat, cane toad and crustacean (yabby) skeletal muscle. Journal of Physiology, 504 (2), 425-437. doi: 10.1111/j.1469-7793.1997.425be.x

Effects of diet induced obesity on rat skeletal muscle Ca2+ handling and cellular adaptations

Singh, Daniel P., Watt, Matthew J. and Launikonis, Bradley S. (2020). Effects of diet induced obesity on rat skeletal muscle Ca2+ handling and cellular adaptations. 64th Annual Meeting of the Biophysical-Society, San Diego, CA, United States, 15-19 February 2020. St. Louis, MO, United States: Cell Press.

Total Calcium Content of Sarcoplasmic Reticulum and Mitochondria in Ryanodine Receptor Variant Muscle

Lamboley, Cedric R., Pearce, Luke and Launikonis, Bradley S. (2020). Total Calcium Content of Sarcoplasmic Reticulum and Mitochondria in Ryanodine Receptor Variant Muscle. In: 64th Annual Meeting of the Biophysical Society, San Diego, CA United States, (98A-99A). 15-19 February 2020.

Determination of heat production in human skeletal muscle from measurements of basal Ca2+ movements

Barclay, Christopher J. and Launikonis, Bradley S. (2019). Determination of heat production in human skeletal muscle from measurements of basal Ca2+ movements. 63rd Annual Meeting of the Biophysical Society, Baltimore, MD, United States, 2-6 March 2019. St. Louis, MO, United States: Cell Press. doi: 10.1016/j.bpj.2018.11.2805

High-throughput screening yields allosteric inhibitors of leaky RyRs for therapeutic development

Rebbeck, Robyn T., Singh, Daniel P., Ginsburg, Kenneth S., Dong, Xiaoqiong, Thomas, David D., Bers, Donald M., Launikonis, Bradley S. and Cornea, Razvan L. (2019). High-throughput screening yields allosteric inhibitors of leaky RyRs for therapeutic development. 63rd Annual Meeting of the Biophysical Society, Baltimore, MD, United States, 2-6 March, 2019. St. Louis, MO, United States: Cell Press. doi: 10.1016/j.bpj.2018.11.2062

Every Action Potential Activates Store-Operated Ca2+ Entry in Skeletal Muscle

Koenig, Xaver and Launikonis, Bradley S. (2018). Every Action Potential Activates Store-Operated Ca2+ Entry in Skeletal Muscle. 62nd Annual Meeting of the Biophysical-Society, San Francisco, CA, United States, Feb 17-21, 2018. Cambridge, MA United States: Cell Press.

High-throughput screening yields allosteric inhibitors of leaky RyRS for therapeutic applications

Rebbeck, Robyn T., Dong, Xiaoqiong, Ginsburg, Kenneth S., Singh, Daniel P., Gillispie, Gregory D., Thomas, David D., Launikonis, Bradley S., Bers, Donald M. and Cornea, Razvan L. (2018). High-throughput screening yields allosteric inhibitors of leaky RyRS for therapeutic applications. 62nd Annual Meeting of the Biophysical Society, San Francisco, California, 17-21 February 2018. St. Louis, MO, United States: Cell Press.

Dantrolene Shifts the Affinity of the Ryanodine Receptor for MG(2+)

Choi, Rocky H., Konig, F. Xaver, Cully, Tanya R. and Launikonis, Bradley S. (2017). Dantrolene Shifts the Affinity of the Ryanodine Receptor for MG(2+). 61st Annual Meeting of the Biophysical-Society, New Orleans, LA United States, Feb 11-15, 2017. Cambridge, MA United States: Cell Press. doi: 10.1016/j.bpj.2016.11.584

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

Hudson, J., Mills, R., Titmarsh, D., Koenig, X., Parker, B., Ryall, J., Quaife-Ryan, G., Voges, H., Hodson, M., Ferguson, C., Drowley, L., Plowright, A., Wang, Q., Gregorevic, P., Xin, M., Thomas, W., Parton, R., Nielsen, L., Launikonis, B., James, D., Elliott, D. and Porrello, E. (2017). Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest. Abstracts for the 65th Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meeting, Perth, Australia, 10 - 13 August 2017. Chatswood, NSW, Australia: Elsevier. doi: 10.1016/j.hlc.2017.06.375

Genetic and histological characterisation of excitation-contraction coupling related structural myopathy cohort

Beecroft, S., Choi, R., McLean, C., Olive, M., Ryan, M., Davis, M., Laing, N., Launikonis, B. and Ravenscroft, G. (2017). Genetic and histological characterisation of excitation-contraction coupling related structural myopathy cohort. 22nd International Annual Congress of the World-Muscle-Society (WMS), Saint Malo France, 3-7 October 2017. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.nmd.2017.06.023

Towards the role of store-operated Ca2+ entry in skeletal muscle physiology

Koenig, X. and Launikonis, B. S. (2017). Towards the role of store-operated Ca2+ entry in skeletal muscle physiology. Joint Meeting of the Federation of European Physiological Societies and the Austrian Physiological Society with Participation of the Czech, French, Italian, Slovak, Slovenian, Swiss and Turkish Physiological Societies, Vienna, Austria, 13–15 September 2017. Chichester, West Sussex United Kingdom: Wiley.

Ryanodine Receptor Activity Regulates the Levels of Ca2+ Extrusion and Store-Operated Ca2+ Entry in Skeletal Muscle

Cully, Tanya R., Choi, Rocky H., Shannon, Thomas R. and Launikonis, Bradley S. (2016). Ryanodine Receptor Activity Regulates the Levels of Ca2+ Extrusion and Store-Operated Ca2+ Entry in Skeletal Muscle. 60th Annual Meeting of the Biophysical-Society, Los Angeles, CA, United States, Feb 27-Mar 02, 2016. Cambridge, MA United States: Cell Press. doi: 10.1016/j.bpj.2015.11.1019

The T-System Provides a Dynamic Ca2+-Buffer in Human Skeletal Muscle Fibres

Cully, Tanya R. and Launikonis, Bradley S. (2016). The T-System Provides a Dynamic Ca2+-Buffer in Human Skeletal Muscle Fibres. 60th Annual Meeting of the Biophysical-Society, Los Angeles, CA, United States, Feb 27-Mar 02, 2016. Cambridge, MA United States: Cell Press. doi: 10.1016/j.bpj.2015.11.3193

Determination of the Junctional Space [Ca2+] Set by Ryanodine Receptor Leak in Slow- and Fast-Twitch Muscle Fibres

Cully, Tanya R. and Launikonis, Bradley S. (2015). Determination of the Junctional Space [Ca2+] Set by Ryanodine Receptor Leak in Slow- and Fast-Twitch Muscle Fibres. -, -, -. Cambridge, MA United States: Cell Press. doi: 10.1016/j.bpj.2014.11.1483

A Chloride Channel Blocker Prevents Inorganic Phosphate Accumulation and Its Effects in the Sarcoplasmic Reticulum of Frog Permeabilized Skeletal Muscle Fibers

Jose Ferreira, Juan, Pequera, German, Launikonis, Bradley, Rios, Eduardo and Brum, Gustavo (2014). A Chloride Channel Blocker Prevents Inorganic Phosphate Accumulation and Its Effects in the Sarcoplasmic Reticulum of Frog Permeabilized Skeletal Muscle Fibers. 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, United States, Feb 15-19, 2014. Cambridge, MA United States: Cell Press. doi: 10.1016/j.bpj.2013.11.2975

Ca2+ Uptake by the Tubular (T-) System Membrane of Rat Fast-Twitch Fibres

Cully, Tanya R., Edwards, Joshua N., Shannon, Thomas R. and Launikonis, Bradley (2014). Ca2+ Uptake by the Tubular (T-) System Membrane of Rat Fast-Twitch Fibres. 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, United States, Feb 15-19, 2014. Cambridge, MA United States: Cell Press. doi: 10.1016/j.bpj.2013.11.749

Resolving the Calcium Release Machinery of Mammalian Fast- and Slow-Twitch Skeletal Muscle

Jayasinghe, Isuru D., Munro, Michelle, Baddeley, David, Launikonis, Bradley S. and Soeller, Christian (2014). Resolving the Calcium Release Machinery of Mammalian Fast- and Slow-Twitch Skeletal Muscle. 58th Annual Meeting of the Biophysical-Society, San Francisco, CA, United States, Feb 15-19, 2014. Cambridge, MA United States: Cell Press. doi: 10.1016/j.bpj.2013.11.736

Store-Operated Ca2+ Entry is a Tonic and Phasic Signal in Skeletal Muscle

Cully, Tanya R. and Launikonis, Bradley S. (2013). Store-Operated Ca2+ Entry is a Tonic and Phasic Signal in Skeletal Muscle. 57th Annual Meeting of the Biophysical Society, Philadelphia Pa, 02-06 February 2013. Maryland Heights, MO United States: Cell Press. doi: 10.1016/j.bpj.2012.11.3364

Injection of rAAV-Orai1 in adult wt and dystrophic mice up-regulates store operated calcium entry

Cully, T. R., Purdue, B. W., Thomas, W. G., Gregorevic, P. and Launikonis, B. S. (2012). Injection of rAAV-Orai1 in adult wt and dystrophic mice up-regulates store operated calcium entry. Collaborative Congress of the European-Society-of-Gene-and-Cell-Therapy/French-Society-of-Cell-and-Gene-Therapy, Versailles, France, 25-29 October 2012. New Rochelle, NY, United States: Mary Ann Liebert.

Growth Hormone Secretagogues Preserved Normal Action Potential Pattern in Mouse Ischemia/reperfusion Cardiomyocytes In Vitro Through Modification of The Voltage-gated L Type Calcium Current and Transient Outward Potassium Current

Ma, Y, Zhang, L, Edwards, JN, Launikonis, B and Chen, C (2011). Growth Hormone Secretagogues Preserved Normal Action Potential Pattern in Mouse Ischemia/reperfusion Cardiomyocytes In Vitro Through Modification of The Voltage-gated L Type Calcium Current and Transient Outward Potassium Current. Scientific Sessions of High Blood Pressure Research, Orlando Fl, Sep 20-24, 2011. doi: 10.1161/HYP.0b013e318234a201

The skeletal muscle inositol trisphosphate receptor communicates with the plasma membrane to mediate store-operated calcium entry

Launikonis, Bradley S., Barnes, Melissa and Stephenson, D. George (2003). The skeletal muscle inositol trisphosphate receptor communicates with the plasma membrane to mediate store-operated calcium entry. 47th Annual Meeting of the Biophysical Society, San Antonio, Texas, 1-5 Mar 2003. Bethesda, MD: Biophysical Society.