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Establishing Design Principles of Polymers for Intracellular Delivery (UWA led ARC Discovery Project) (2022–2025)

Abstract:
Engineered polymers have played a central role in the field of bionanotechnology by enabling targeted nanoscale cell interactions. Progress in the field of intracellular delivery is currently affected by a major bottleneck due to the absence of effective polymers that is applicable across the range of bimolecular cargoes. In essence depending on the type of cargo: DNA, RNA or protien, the polymer needs programmability. The limited tunability of traditional polymers agents makes them unsuitable for this particular application. The multidisciplinary project addresses this significant problem by engineering novel sequences of defined polymer based nanoscale agents to achieve efficient delivery in cells.
Grant type:
University of Western Australia
Researchers:

  • Professor Kristofer Thurecht

    Senior Group Leader and Deputy Dire
    Centre for Advanced Imaging
    Australian Institute for Bioengineering and Nanotechnology
    Affiliate PRF & Group Leader
    Australian Institute for Bioengineering and Nanotechnology

  • Dr Craig Bell

    Advance Qld Industry Fellow
    Centre for Advanced Imaging
    Australian Institute for Bioengineering and Nanotechnology
Funded by:
The University of Western Australia