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DNA exhibits new self-assembled structures due to clustered DNA methylation (2018–2021)

Abstract:
Epigenetics controls whether genes and genetic programs are turned on or off in living systems. Our investigators have recently discovered that key physical properties of native DNA polymers are strongly influenced by epigenetic patterns created by living organisms. This project aims to build on this discovery to develop a highly innovative and simple technology to investigate detailed epigenetic patterns in DNA by directly interrogating the physical properties of DNA polymers in their native state. By performing research to fully understand this phenomenon, this project aims to provide entirely new tools for the study of epigenetics with broad potential applications in the life sciences, biotechnology and nanotechnology.
Grant type:
ARC Discovery Projects
Researchers:

  • Professor Matt Trau

    ARC Australian Laureate Fellow
    Australian Institute for Bioengineering and Nanotechnology
    ARC Laureate Fellow
    School of Chemistry and Molecular Biosciences
    Faculty of Science

  • Dr Darren Korbie

    Senior Research Fellow
    Australian Institute for Bioengineering and Nanotechnology
Funded by:
Australian Research Council