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Novel polymeric microparticles for slow-release intrathecal delivery of analgesics (2010–2013)

Abstract:
Unrelieved pain is a large area of unmet medical need, adversely affecting the lives of millions of people worldwide. This project seeks to utilise innovative, green, polymer chemistry to develop bioerodable polymer particles to deliver the novel analgesic agent, Xen2174, into the spinal fluid in close proximity to its target receptors. The overall goal is to use this approach to produce prolonged periods of analgesia in the 10-30% of patients who do not obtain benefit from existing analgesic treatments delivered by less invasive routes. This bioerodable polymer technology has potential broad application to a wide range of drug treatments.
Grant type:
ARC Linkage Projects
Researchers:

  • Emeritus Professor Maree Smith

    Emeritus Professor
    School of Biomedical Sciences
    Faculty of Medicine

  • Professor Andrew Whittaker

    Professorial Research Fellow and Se
    Australian Institute for Bioengineering and Nanotechnology
    Professorial Research Fellow and Se
    Australian Institute for Bioengineering and Nanotechnology
    Affiliate of Australian Research Co
    ARC Centre of Excellence-Green Electrochemical Transformation of Carbon Dioxide
    Faculty of Engineering, Architecture and Information Technology
    Affiliate Professor
    School of Chemistry and Molecular Biosciences
    Faculty of Science

  • Professor Kristofer Thurecht

    Senior Group Leader and Deputy Dire
    Centre for Advanced Imaging
    Australian Institute for Bioengineering and Nanotechnology
    Affiliate PRF & Group Leader
    Australian Institute for Bioengineering and Nanotechnology
Funded by:
Australian Research Council