The University of Queensland

Locked nucleic acids: promising nucleic acid analogs for therapeutic applications

Veedu, Rakesh N. and Wengel, Jesper (2012). Locked nucleic acids: promising nucleic acid analogs for therapeutic applications. Chemistry and biology of artificial nucleic acids. (pp. 159-165) edited by Martin Egli and Piet Herdewijn. Weinheim, Germany: Wiley-VCH.

Locked nucleic acid oligonucleotides towards clinical applications

Veedu, Rakesh N. and Wengel, Jesper (2011). Locked nucleic acid oligonucleotides towards clinical applications. Medicinal Chemistry of Nucleic Acids. (pp. 355-348) edited by Li-He Zhang, Zhen Xi and Jyoti Chattopadhyaya. New Jersey, U.S.A: John Wiley & Sons.

Development of DNA aptamers targeting low-molecular-weight amyloid-β peptide aggregates in vitro

Chakravarthy, Madhuri, AlShamaileh, Hadi, Huang, He, Tannenberg, Rudi K., Chen, Suxiang, Worrall, Simon, Dodd, Peter R. and Veedu, Rakesh N. (2018). Development of DNA aptamers targeting low-molecular-weight amyloid-β peptide aggregates in vitro. Chemical Communications, 54 (36), 4593-4596. doi: 10.1039/c8cc02256a

Self-assembling asymmetric peptide-dendrimer micelles - a platform for effective and versatile in vitro nucleic acid delivery

Kokil, Ganesh R., Veedu, Rakesh N., Le, Bao Tri, Ramm, Grant A. and Parekh, Harendra S. (2018). Self-assembling asymmetric peptide-dendrimer micelles - a platform for effective and versatile in vitro nucleic acid delivery. Scientific Reports, 8 (1) 4832, 4832. doi: 10.1038/s41598-018-22902-9

Next generation nucleic acid aptamers with two base modified nucleotides improve the binding affinity and potency

Naduvile Veedu, Rakesh and Al Shamaileh, Hadi (2017). Next generation nucleic acid aptamers with two base modified nucleotides improve the binding affinity and potency. ChemBioChem, 18 (16), 1565-1567. doi: 10.1002/cbic.201700276

Development of an efficient G-quadruplex stabilized thrombin binding aptamer containing 3-carbon spacer molecule

Aaldering, Lukas J. , Poongavanam, Vasanthanathan , Murugan, N. Arul , Jørgensen, Per Trolle , Wengel, Jesper and Veedu, Rakesh N. (2017). Development of an efficient G-quadruplex stabilized thrombin binding aptamer containing 3-carbon spacer molecule. ChemBioChem, 18 (8), 755-763. doi: 10.1002/cbic.201600654

Nucleic acid-based theranostics for tackling Alzheimer's disease

Chakravarthy, Madhuri, Chen, Suxiang, Dodd, Peter R. and Veedu, Rakesh N. (2017). Nucleic acid-based theranostics for tackling Alzheimer's disease. Theranostics, 7 (16) 21529, 3933-3947. doi: 10.7150/thno.21529

Targeting VEGF with LNA-stabilized G-rich oligonucleotide for efficient breast cancer inhibition

Edwards, Stacey L., Poongavanam, Vasanthanathan, Kanwar, Jagat R., Roy, Kislay, Hillman, Kristine M., Prasad, Neerati, Leth-Larsen, Rikke, Petersen, Michael, Marusic, Maja, Plavec, Janez, Wengel, Jesper and Veedu, Rakesh N. (2015). Targeting VEGF with LNA-stabilized G-rich oligonucleotide for efficient breast cancer inhibition. Chemical Communications, 51 (46), 9499-9502. doi: 10.1039/c5cc02756j

Comments on photochromism of 3-(3-pyridyl)sydnone and 4-alkenylsydnones

Wentrup, Curt, Kvaskoff, David and Veedu, Rakesh N (2015). Comments on photochromism of 3-(3-pyridyl)sydnone and 4-alkenylsydnones. Journal of Photochemistry and Photobiology A: Chemistry, 298, 62-63. doi: 10.1016/j.jphotochem.2014.10.010

Smart functional nucleic acid chimeras: enabling tissue specific RNA targeting therapy

Aaldering, Lukas J., Tayeb, Hossam, Krishnan, Shilpa, Fletcher, Susan, Wilton, Stephen D. and Veedu, Rakesh N. (2015). Smart functional nucleic acid chimeras: enabling tissue specific RNA targeting therapy. RNA Biology, 12 (4), 412-425. doi: 10.1080/15476286.2015.1017234

Type 2 diabetes mellitus: limitations of conventional therapies and intervention with nucleic acid-based therapeutics

Kokil, Ganesh R., Veedu, Rakesh N., Ramm, Grant A., Prins, Johannes B. and Parekh, Harendra S. (2015). Type 2 diabetes mellitus: limitations of conventional therapies and intervention with nucleic acid-based therapeutics. Chemical Reviews, 115 (11), 4719-4743. doi: 10.1021/cr5002832

Computational investigation of Locked Nucleic Acid (LNA) nucleotides in the active sites of DNA polymerases by molecular docking simulations

Poongavanam, Vasanthanathan, Madala, Praveen K., Højland, Torben and Veedu, Rakesh N. (2014). Computational investigation of Locked Nucleic Acid (LNA) nucleotides in the active sites of DNA polymerases by molecular docking simulations. PLoS One, 9 (7) e102126, 1-7. doi: 10.1371/journal.pone.0102126

Quencher-free molecular beacons as probes for oligonucleotides containing CAG repeat sequences

Kim K.T., Veedu R.N., Seo Y.J. and Kim B.H. (2014). Quencher-free molecular beacons as probes for oligonucleotides containing CAG repeat sequences. Chemical Communications, 50 (13), 1561-1563. doi: 10.1039/c3cc48853e

Multifunctional and multitargeted nanoparticles for drug delivery to overcome barriers of drug resistance in human cancers

Dawar, Swati, Singh, Neha, Kanwar, Rupinder K., Kennedy, Richard Lee, Veedu, Rakesh N., Zhou, Shu-Feng, Krishnakumar, Subramanian, Hazra, Sarbani, Sasidharan, Sreenivasan, Duan, Wei and Kanwar, Jagat R. (2013). Multifunctional and multitargeted nanoparticles for drug delivery to overcome barriers of drug resistance in human cancers. Drug Discovery Today, In Press, Corrected Proof (23-24), 1-9. doi: 10.1016/j.drudis.2013.09.009

G-rich VEGF aptamer with locked and unlocked nucleic acid modifications exhibits a unique G-quadruplex fold

Marušič, Maja, Veedu, Rakesh N., Wengel, Jesper and Plavec, Janez (2013). G-rich VEGF aptamer with locked and unlocked nucleic acid modifications exhibits a unique G-quadruplex fold. Nucleic Acids Research, Advance Access (20), 1-13. doi: 10.1093/nar/gkt697

Nucleic acid aptamers as novel class of therapeutics to mitigate Alzheimer's disease pathology

Tannenberg, Rudi K., Al Shamaileh, Hadi, Lauridsen, Lasse H., Kanwar, Jagat R., Dodd, Peter R. and Veedu, Rakesh N. (2013). Nucleic acid aptamers as novel class of therapeutics to mitigate Alzheimer's disease pathology. Current Alzheimer Research, 10 (4), 442-448. doi: 10.2174/1567205011310040009

Synthesis of DNA Oligonucleotides containing C5-Ethynylbenzenesulfonamide-modified nucleotides (EBNA) by polymerases towards the construction of base functionalized nucleic acids

Goubet, Astrid, Chardon, Antoine, Kumar, Pawan, Sharma, Pawan K. and Veedu, Rakesh N. (2013). Synthesis of DNA Oligonucleotides containing C5-Ethynylbenzenesulfonamide-modified nucleotides (EBNA) by polymerases towards the construction of base functionalized nucleic acids. Bioorganic & Medicinal Chemistry Letters, 23 (3), 761-763. doi: 10.1016/j.bmcl.2012.11.096

Aptamer-targeted hyperbranched polymers: towards greater specificity for tumours in vivo

Coles, Daniel J., Rolfe, Barbara E., Boase, Nathan R. B., Veedu, Rakesh N. and Thurecht, Kristofer J. (2013). Aptamer-targeted hyperbranched polymers: towards greater specificity for tumours in vivo. Chemical Communications, 49 (37), 3836-3838. doi: 10.1039/c3cc00127j

Selenomethylene locked nucleic acid enables reversible hybridization in response to redox changes

Morihiro, Kunihiko, Kodama, Tetsuya, Kentefu, Moai, Yoshihiro, Veedu, Rakesh N. and Obika, Satoshi (2013). Selenomethylene locked nucleic acid enables reversible hybridization in response to redox changes. Angewandte Chemie-International Edition, 52 (19), 5074-5078. doi: 10.1002/anie.201300555

Targeted multimodal liposomes for nano-delivery and imaging: An avenger for drug resistance and cancer

Gurudevan, Sneha, Kanwar, Rupinder K., Veedu, Rakesh N., Sasidharan, Sreenivasan, Kennedy, Richard L., Walder, Ken, Prasad, Neerati and Kanwar, Jagat R. (2013). Targeted multimodal liposomes for nano-delivery and imaging: An avenger for drug resistance and cancer. Current Gene Therapy, 13 (5), 322-334. doi: 10.2174/156652321305131212123558

Synthesis of selenomethylene-locked nucleic acid (SeLNA)-modified oligonucleotides by polymerases

Wheeler, Megan, Chardon, Antoine, Goubet, Astrid, Morihiro, Kunihiko, Tsan, Sze Yee, Edwards, Stacey L., Kodama, Tetsuya, Obika, Satoshi and Veedu, Rakesh N. (2012). Synthesis of selenomethylene-locked nucleic acid (SeLNA)-modified oligonucleotides by polymerases. Chemical Communications, 48 (89), 11020-11022. doi: 10.1039/C2CC36464F

Nucleic acid aptamers against biotoxins: a new paradigm toward the treatment and diagnostic approach

Lauridsen, Lasse Holm and Veedu, Rakesh N. (2012). Nucleic acid aptamers against biotoxins: a new paradigm toward the treatment and diagnostic approach. Nucleic Acid Therapeutics, 22 (6), 371-379. doi: 10.1089/nat.2012.0377

Cleavage and protection of locked nucleic acid-modified DNA by restriction endonucleases

Crouzier, Lucile, Dubois, Camille, Wengel, Jesper and Veedu, Rakesh N. (2012). Cleavage and protection of locked nucleic acid-modified DNA by restriction endonucleases. Bioorganic and Medicinal Chemistry Letters, 22 (14), 4836-4838. doi: 10.1016/j.bmcl.2012.05.113

Rapid one-step selection method for generating nucleic acid aptamers: Development of a DNA aptamer against α-bungarotoxin

Lauridsen, Lasse H., Shamaileh, Hadi A., Edwards, Stacey L., Taran, Elena and Veedu, Rakesh N. (2012). Rapid one-step selection method for generating nucleic acid aptamers: Development of a DNA aptamer against α-bungarotoxin. PLoS One, 7 (7) e41702, e41702.1-e41702.6. doi: 10.1371/journal.pone.0041702

Enzymatic polymerisation involving 2'-amino-LNA nucleotides

Johannsen, Marie W., Veedu, Rakesh N., Madsen, Andreas Stahl and Wengel, Jesper (2012). Enzymatic polymerisation involving 2'-amino-LNA nucleotides. Bioorganic and Medicinal Chemistry Letters, 22 (10), 3522-3526. doi: 10.1016/j.bmcl.2012.03.073

Efficient reverse transcription using locked Nucleic Acid Nucleotides towards the evolution of Nuclease resistant RNA Aptamers

Crouzier, Lucile, Dubois, Camille, Edwards, Stacey L., Lauridsen, Lasse H., Wengel, Jesper and Veedu, Rakesh N. (2012). Efficient reverse transcription using locked Nucleic Acid Nucleotides towards the evolution of Nuclease resistant RNA Aptamers. PLoS One, 7 (4), e35990-1-e35990-5. doi: 10.1371/journal.pone.0035990

Enzymatic recognition of 2'-modified ribonucleoside 5'-triphosphates: Towards the evolution of versatile aptamers

Lauridsen, Lasse H., Rothnagel, Joseph A. and Veedu, Rakesh N. (2012). Enzymatic recognition of 2'-modified ribonucleoside 5'-triphosphates: Towards the evolution of versatile aptamers. ChemBioChem, 13 (1), 19-25. doi: 10.1002/cbic.201100648

Amplification and re-generation of LNA-modified libraries

Doessing, Holger, Hanse, Lykke H., Veedu, Rakesh N., Wengel, Jesper and Vester, Birte (2012). Amplification and re-generation of LNA-modified libraries. Molecules, 17 (11), 13087-13097. doi: 10.3390/molecules171113087

Enzymatic synthesis of DNA strands containing alpha-L-LNA (alpha-L-configured locked nucleic acid) thymine nucleotides

Højland, Torben, Veedu, Rakesh N., Vester, Birte and Wengel, Jesper (2012). Enzymatic synthesis of DNA strands containing alpha-L-LNA (alpha-L-configured locked nucleic acid) thymine nucleotides. Artificial DNA, 3 (1), 14-21. doi: 10.4161/adna.19272

Polymorphism in 3-Pyridylsydnone: Preparative and Structural Aspects

Bernhardt, Paul V., Kvaskoff, David, Veedu, Rakesh Naduvile and Wentrup, Curt (2012). Polymorphism in 3-Pyridylsydnone: Preparative and Structural Aspects. Australian Journal of Chemistry, 65 (4), 376-380. doi: 10.1071/CH12041

Stepping towards highly flexible aptamers: Enzymatic recognition studies of unlocked nucleic acid nucleotides

Dubois, Camille, Campbell, Meghan A., Edwards, Stacey L., Wengel, Jesper and Veedu, Rakesh N. (2012). Stepping towards highly flexible aptamers: Enzymatic recognition studies of unlocked nucleic acid nucleotides. Chemical Communications, 44 (44), 5503-5505. doi: 10.1039/c2cc31316b

Photoligation of self-assembled DNA constructs containing anthracene-functionalized 2'-amino-LNA monomers

Pasternak, Karol, Pasternak, Anna, Gupta, Pankaj, Veedu, Rakesh N. and Wengel, Jesper (2011). Photoligation of self-assembled DNA constructs containing anthracene-functionalized 2'-amino-LNA monomers. Bioorganic and Medicinal Chemistry, 19 (24), 7407-7415. doi: 10.1016/j.bmc.2011.10.052

Polymerase-directed synthesis of C5-ethynyl locked nucleic acids

Veedu, Rakesh N., Burri, Harsha V., Kumar, Pawan, Sharma, Pawan K., Hrdlicka, Patrick J., Vester, Birte and Wengel, Jesper (2010). Polymerase-directed synthesis of C5-ethynyl locked nucleic acids. Bioorganic and Medicinal Chemistry Letters, 20 (22), 6565-6568. doi: 10.1016/j.bmcl.2010.09.044

Locked nucleic acids: Promising nucleic acid analogs for therapeutic applications

Veedu, Rakesh N. and Wengel, Jesper (2010). Locked nucleic acids: Promising nucleic acid analogs for therapeutic applications. Chemistry and Biodiversity, 7 (3), 536-542. doi: 10.1002/cbdv.200900343

Polymerase directed incorporation studies of LNA-G nucleoside 5'-triphosphate and primer extension involving all four LNA nucleotides

Veedu, Rakesh N., Vester, Birte and Wengel, Jesper (2010). Polymerase directed incorporation studies of LNA-G nucleoside 5'-triphosphate and primer extension involving all four LNA nucleotides. New Journal of Chemistry, 34 (5), 877-879. doi: 10.1039/b9nj00628a

Microwave-induced molecular rearrangements. Flash thermolysis in the gas-phase and in solution: Synthesis of quinolones and naphthyridones

Lecoq, Delphine, Chalmers, Benjamin A., Veedu, Rakesh N., Kvaskoff, David, Bernhardt, Paul V. and Wentrup, Curt (2009). Microwave-induced molecular rearrangements. Flash thermolysis in the gas-phase and in solution: Synthesis of quinolones and naphthyridones. Australian Journal of Chemistry, 62 (12), 1631-1638. doi: 10.1071/CH09447

Expanding the applications of locked nucleic acids

Veedu, Rakesh N. and Wengel, Jesper (2009). Expanding the applications of locked nucleic acids. Indian Journal of Chemistry Section B: Organic and Medicinal Chemistry, 48B (12), 1709-1711.

Locked nucleic acid as a novel class of therapeutic agents

Veedu, Rakesh N. and Wengel, Jesper (2009). Locked nucleic acid as a novel class of therapeutic agents. RNA Biology, 6 (3), 321-323.

Nuclease resistant methylphosphonate-DNA/LNA chimeric oligonucleotides

Nagahama, Koji, Veedu, Rakesh N. and Wengel, Jesper (2009). Nuclease resistant methylphosphonate-DNA/LNA chimeric oligonucleotides. Bioorganic and Medicinal Chemistry Letters, 19 (10), 2707-2709. doi: 10.1016/j.bmcl.2009.03.116

Efficient Enzymatic Synthesis of LNA-modified DNA duplexes using KOD DNA polymerase

Veedu, Rakesh N., Vester, Birte and Wengel, Jesper (2009). Efficient Enzymatic Synthesis of LNA-modified DNA duplexes using KOD DNA polymerase. Organic and Biomolecular Chemistry, 7 (7), 1404-1409. doi: 10.1039/b819946a

Locked nucleic acid nucleoside triphosphates and polymerases: On the way towards evolution of LNA aptamers

Veedu, Rakesh N. and Wengel, Jesper (2009). Locked nucleic acid nucleoside triphosphates and polymerases: On the way towards evolution of LNA aptamers. Molecular BioSystems, 5 (8), 787-792. doi: 10.1039/b905513b

Reaction of iminopropadienones with amines - Formation of zwitterionic intermediates, ketenes, and ketenimines

Naduvile Veedu, Rakesh, Kokas, Okanya J., Couturier-Tamburelli, Isabelle, Koch, Rainer, Aycard, Jean-Pierre, Borget, Fabien and Wentrup, Curt (2008). Reaction of iminopropadienones with amines - Formation of zwitterionic intermediates, ketenes, and ketenimines. Journal of Physical Chemistry A, 112 (40), 9742-9750. doi: 10.1021/jp803351q

Polymerase chain reaction and transcription using locked nucleic acid nucleotide triphosphates

Veedu, Rakesh N., Vester, Birte and Jesper Wengel (2008). Polymerase chain reaction and transcription using locked nucleic acid nucleotide triphosphates. Journal of The American Chemical Society, 130 (26), 8124-8125. doi: 10.1021/ja801389n

Twisted push-pull ethylenes

Naduvile Veedu, Rakesh, Bernhardt, Paul V., Koch, Rainer and Wentrup, Curt (2008). Twisted push-pull ethylenes. Australian Journal of Chemistry, 61 (10), 805-812. doi: 10.1071/CH08277

Enzymatic incorporations of LNA nucleotides into DNA strands

Veedu, Rakesh N., Vester, Birte and Wengel, Jesper (2007). Enzymatic incorporations of LNA nucleotides into DNA strands. ChemBioChem, 8 (5), 490-492. doi: 10.1002/cbic.200600501

Carboxyketenes from 4-Hydroxy-1,3-oxazin-6-ones and Meldrum's acid derivatives

George, L., Naduvile Veedu, R., Sheibani, H., Taherpour, A., Flammang, R. and Wentrup, C. (2007). Carboxyketenes from 4-Hydroxy-1,3-oxazin-6-ones and Meldrum's acid derivatives. Journal of Organic Chemistry, 72 (4), 1399-1404. doi: 10.1021/jo062319t

In vitro incorporation of LNA nucleotides

Veedu, Rakesh N., Vester, Birte and Wengel, Jesper (2007). In vitro incorporation of LNA nucleotides. Nucleosides, Nucleotides and Nucleic Acids, 26 (8-9), 1207-1210. doi: 10.1080/15257770701527844

A cyclopropabenzenylidenethenone (Propadienone) via a new route to alkylidenecycloproparenes

Halton, B., Dixon, G., Jones, C. M., Parkin, C. T., Naduvile Veedu, R., Bornemann, H. and Wentrup, C. (2005). A cyclopropabenzenylidenethenone (Propadienone) via a new route to alkylidenecycloproparenes. Organic Letters, 7 (5), 949-952. doi: 10.1021/ol050095f

Iminopropadienones R-N=C=C=C=O and carbon suboxide, C3O2. Theoretical and experimental 13C NMR spectra

Koch, R., Bruhn, T., Naduvile Veedu, R. and Wentrup, C. (2004). Iminopropadienones R-N=C=C=C=O and carbon suboxide, C3O2. Theoretical and experimental 13C NMR spectra. Journal of Molecular Structure (Theochem), 686 (1-3), 31-36. doi: 10.1016/j.theochem.2004.07.027

Sydnone photochemistry: Direct observation of earl's bicyclic lactone valence isomers (oxadiazabicyclo[2.1.0] pentanones), formation of carbodiimides, reaction mechanism, and photochromism

Veedu, Rakesh N., Kvaskoff, David and Wentrup, Curt (2014). Sydnone photochemistry: Direct observation of earl's bicyclic lactone valence isomers (oxadiazabicyclo[2.1.0] pentanones), formation of carbodiimides, reaction mechanism, and photochromism. 6th Heron Island Conference on Reactive Intermediates and Unusual Molecules, Heron Island, Qld, Australia, 7 - 13 July 2013. Collingwood, VIC Australia: CSIRO. doi: 10.1071/CH13536

Enzymatic synthesis of LNA oligonucleotides using polymerases

Veedu, Rakesh N., Vester, Birte and Wengel, Jesper (2008). Enzymatic synthesis of LNA oligonucleotides using polymerases. XIVth Symposium on Chemistry of Nucleic Acids Components, Cesky Krumlov, Czech Republic, 8-13 June 2008. Prague, Czech Republic: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic,.

Novel applications of locked nucleic acids

Veedu, Rakesh N., Vester, Birte and Wengel, Jesper (2007). Novel applications of locked nucleic acids. Fifth International Symposium on Nucleic Acids Chemistry, Osaka, Japan, 20-22 November 2007. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/nass/nrm015

Enzymatic incorporation of LNA nucleotides

Wengel, Jesper, Vester, Birte and Veedu, Rakesh N. (2009). Enzymatic incorporation of LNA nucleotides. WO/2009/039862.

Syntheses and reactions of iminopropadienones, sydnones and oxazinones.

Veedu, Rakesh Naduvile (2006). Syntheses and reactions of iminopropadienones, sydnones and oxazinones.. PhD Thesis, School of Molecular and Microbial Sciences, The University of Queensland.