Professor David Mudge

ATH - Professor

Princess Alexandra Hospital Southside Clinical Unit
Faculty of Medicine

Overview

David Mudge is a consultant nephrologist at Princess Alexandra Hospital and visiting nephrologist at Redland Hospital

My research interests are varied and include post-transplant anaemia and iron metabolism, and novel measures of iron status such as hepcidin; improving dialysis outcomes though the implementation of evidence-based guidelines; the investigation of a recently discovered sulfate transporter in patients with kidney stones; kidney disease due to thrombotic microangiopathy (particularly aHUS) and the use of honey to prevent infections in dialysis patients.

I am committed to teaching medical students and young nephrologists, particularly in interventional nephrology and bedside ultrasonography.

Research Impacts

The impact of my research in peritoneal dialysis has been a significant improvement in PD-related infection rates in Australia, which until a few years ago were worse than many other countries in the world. Through a variety of initiatives including a project aiming to improve the use of evidence-based guidelines in clinical practice, we have seen a significant improvement in PD-related infections (particularly peritonitis but also exit-site infections), one of the most significant contributors to peritoneal dialysis technique failure.

In kidney transplantation my research has helped to clarify the role of immune suppressing medications on iron availability and anaemia and has looked at novel ways of measuring iron status in patients with kidney disease as well as better ways of enhancing iron stores in these patients.

Publications

  • Burnett, Cameron, Chandler, S., Jegatheesan, D., Pearch, B., Viecelli, A. and Mudge, D. W. (2024). The stuck haemodialysis catheter—a case report of a rare but dreaded complication following kidney transplantation. BMC Nephrology, 25 (1) 104. doi: 10.1186/s12882-024-03507-z

  • Strand, Vibeke, Jayne, David R W, Horomanski, Audra, Yue, Huibin, Bekker, Pirow, Merkel, Peter A, Au Peh, Chen, Chakera, Aron, Cooper, Bruce, Kurtkoti, Jagadeesh, Langguth, Daman, Levidiotis, Vicki, Luxton, Grant, Mount, Peter, Mudge, David, Noble, Euan, Phoon, Richard, Ranganathan, Dwarakanathan, Ritchie, Angus, Ryan, Jessica, Suranyi, Michael, Rosenkranz, Alexander, Lhotta, Karl, Kronbichler, Andreas, Demoulin, Nathalie, Bovy, Christophe, Hellemans, Rachel, Hougardy, Jean-Michel, Sprangers, Ben ... on behalf of the ADVOCATE Study Group (2023). The impact of treatment with avacopan on health-related quality of life in antineutrophil cytoplasmic antibody-associated vasculitis: a post-hoc analysis of data from the ADVOCATE trial. The Lancet Rheumatology, 5 (8), e451-e460. doi: 10.1016/S2665-9913(23)00092-9

  • Cortazar, Frank B., Niles, John L., Jayne, David R.W., Merkel, Peter A., Bruchfeld, Annette, Yue, Huibin, Schall, Thomas J., Bekker, Pirow, Peh, C. Au, Chakera, A., Cooper, B., Kurtkoti, J., Langguth, D., Levidiotis, V., Luxton, G., Mount, P., Mudge, D., Noble, E., Phoon, R., Ranganathan, D., Ritchie, A., Ryan, J., Suranyi, M., Rosenkranz, A., Lhotta, K., Kronbichler, A., Demoulin, N., Bovy, C., Hellemans, R. ... Wasko, M. Chester (2023). Renal recovery for patients with ANCA-associated vasculitis and low eGFR in the ADVOCATE trial of avacopan. Kidney International Reports, 8 (4), 860-870. doi: 10.1016/j.ekir.2023.01.039

View all Publications

Publications

Book Chapter

  • Nguyen, Thu T., Palmer, Suetonia C., Cho, Yeoungjee, Mudge, David W., Strippoli, Giovanni F.M., Craig, Jonathan C., Johnson, David W. and Htay, Htay (2022). Peritoneal Dialysis: Infections. Evidence-Based Nephrology, Second Edition: Volumes 1,2. (pp. 138-155) wiley. doi: 10.1002/9781119105954.ch48

  • Abdul Razak, K., Mudge, D. W. and Johnson, D. W. (2014). Anaemia: prevalence, risk factors and management with a focus on chronic kidney disease. Anemia: prevalence, risk factors and management strategies. (pp. 123-146) Hauppauge, NY United States: Nova Science Publishers.

  • Sharma, Siddharth, Oliver, Kimberley and Mudge, David W. (2013). Advances in antibody-mediated rejection. Current issues and future direction in kidney transplantation. (pp. 445-462) edited by Thomas Rath. Rijeka, Croatia: InTech Open. doi: 10.5772/54855

  • Bose, Bhadran and Mudge, David (2011). Post-transplant anaemia. After the kidney transplant - The patients and their allograft. (pp. 195-204) edited by Jorge Ortiz and Jason Andre. Croatia: Intech Open Access.

Journal Article

Conference Publication