The University of Queensland

RAFT polymer–antibody conjugation: squaramide ester chemistry leads to conjugates with a therapeutic anti-EGFR antibody with full retention of activity and increased tumor uptake in vivo

Ardana, Aditya, Ghosh, Saikat, Huda, Pie, Fletcher, Nicholas L., Thurecht, Kristofer J. and Williams, Charlotte C. (2023). RAFT polymer–antibody conjugation: squaramide ester chemistry leads to conjugates with a therapeutic anti-EGFR antibody with full retention of activity and increased tumor uptake in vivo. Molecular Pharmaceutics, 20 (6), 3073-3087. doi: 10.1021/acs.molpharmaceut.3c00085

Pharmacokinetics and Biodistribution of Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in Glioblastoma

Ghosh, Saikat, Fletcher, Nicholas L., Huda, Pie, Houston, Zachary H., Howard, Christopher B., Lund, Maria E., Lu, Yanling, Campbell, Douglas H., Walsh, Bradley J. and Thurecht, Kristofer J. (2023). Pharmacokinetics and Biodistribution of Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in Glioblastoma. Molecular pharmaceutics, 20 (3), 1549-1563. doi: 10.1021/acs.molpharmaceut.2c00760

Pre-targeting of polymeric nanomaterials to balance tumour accumulation and clearance

Fletcher, N. L., Prior, A., Choy, O., Humphries, J., Huda, P., Ghosh, S., Houston, Z. H., Bell, C. A. and Thurecht, K. J. (2022). Pre-targeting of polymeric nanomaterials to balance tumour accumulation and clearance. Chemical Communications, 58 (57), 7912-7915. doi: 10.1039/d2cc02443h

Antibody-based formats to target glioblastoma: overcoming barriers to protein drug delivery

Ghosh, Saikat, Huda, Pie, Fletcher, Nicholas L., Howard, Christopher B., Walsh, Bradley, Campbell, Douglas, Pinkham, Mark B. and Thurecht, Kristofer J. (2022). Antibody-based formats to target glioblastoma: overcoming barriers to protein drug delivery. Molecular Pharmaceutics, 19 (5), 1233-1247. doi: 10.1021/acs.molpharmaceut.1c00996

Understanding nanomedicine treatment in an aggressive spontaneous brain cancer model at the stage of early blood brain barrier disruption

Janowicz, Phillip W., Houston, Zachary H., Bunt, Jens, Fletcher, Nicholas L., Bell, Craig A., Cowin, Gary, Howard, Christopher B., Taslima, Dewan, Westra van Holthe, Nicholas, Prior, Amber, Soh, Vanessa, Ghosh, Saikat, Humphries, James, Huda, Pie, Mahler, Stephen M., Richards, Linda J. and Thurecht, Kristofer J. (2022). Understanding nanomedicine treatment in an aggressive spontaneous brain cancer model at the stage of early blood brain barrier disruption. Biomaterials, 283 121416, 121416. doi: 10.1016/j.biomaterials.2022.121416

Clinical development of an anti-GPC-1 antibody for the treatment of cancer

Ghosh, Saikat, Huda, Pie, Fletcher, Nicholas, Campbell, Douglas, Thurecht, Kristofer J. and Walsh, Bradley (2022). Clinical development of an anti-GPC-1 antibody for the treatment of cancer. Expert Opinion on Biological Therapy, 22 (5), 603-613. doi: 10.1080/14712598.2022.2033204

Prion-like p53 amyloids in cancer

Navalkar, Ambuja, Ghosh, Saikat, Pandey, Satyaprakash, Paul, Ajoy, Datta, Debalina and Maji, Samir K. (2020). Prion-like p53 amyloids in cancer. Biochemistry, 59 (2), 146-155. doi: 10.1021/acs.biochem.9b00796

p53 amyloid formation leading to its loss of function: implications in cancer pathogenesis

Ghosh, Saikat, Salot, Shimul, Sengupta, Shinjinee, Navalkar, Ambuja, Ghosh, Dhiman, Jacob, Reeba, Das, Subhadeep, Kumar, Rakesh, Jha, Narendra Nath, Sahay, Shruti, Mehra, Surabhi, Mohite, Ganesh M., Ghosh, Santanu K., Kombrabail, Mamata, Krishnamoorthy, Guruswamy, Chaudhari, Pradip and Maji, Samir K. (2017). p53 amyloid formation leading to its loss of function: implications in cancer pathogenesis. Cell Death and Differentiation, 24 (10), 1784-1798. doi: 10.1038/cdd.2017.105

Amyloid formation of growth hormone in presence of zinc: relevance to its storage in secretory granules

Jacob, Reeba S., Das, Subhadeep, Ghosh, Saikat, Anoop, Arunagiri, Jha, Narendra Nath, Khan, Tuhin, Singru, Praful, Kumar, Ashutosh and Maji, Samir K. (2016). Amyloid formation of growth hormone in presence of zinc: relevance to its storage in secretory granules. Scientific Reports, 6 (1) 23370, 23370. doi: 10.1038/srep23370

Investigating the intrinsic aggregation potential of evolutionarily conserved segments in p53

Ghosh, Saikat, Ghosh, Dhiman, Ranganathan, Srivastav, Anoop, A., Kumar, Santosh P., Jha, Narendra Nath, Padinhateeri, Ranjith and Maji, Samir K. (2014). Investigating the intrinsic aggregation potential of evolutionarily conserved segments in p53. Biochemistry, 53 (38), 5995-6010. doi: 10.1021/bi500825d

Elucidating the role of disulfide bond on amyloid formation and fibril reversibility of somatostatin-14: relevance to its storage and secretion

Anoop, Arunagiri, Ranganathan, Srivastav, Das Dhaked, Bhagwan, Jha, Narendra Nath, Pratihar, Supriya, Ghosh, Saikat, Sahay, Shruti, Kumar, Santosh, Das, Subhadeep, Kombrabail, Mamata, Agarwal, Kumud, Jacob, Reeba S., Singru, Praful, Bhaumik, Prasenjit, Padinhateeri, Ranjith, Kumar, Ashutosh and Maji, Samir K. (2014). Elucidating the role of disulfide bond on amyloid formation and fibril reversibility of somatostatin-14: relevance to its storage and secretion. Journal of Biological Chemistry, 289 (24), 16884-16903. doi: 10.1074/jbc.m114.548354

The Parkinson’s disease-associated H50Q mutation accelerates α-synuclein aggregation in vitro

Ghosh, Dhiman, Mondal, Mrityunjoy, Mohite, Ganesh M., Singh, Pradeep K., Ranjan, Priyatosh, Anoop, A., Ghosh, Saikat, Jha, Narendra Nath, Kumar, Ashutosh and Maji, Samir K. (2013). The Parkinson’s disease-associated H50Q mutation accelerates α-synuclein aggregation in vitro. Biochemistry, 52 (40), 6925-6927. doi: 10.1021/bi400999d

Assembly of Bacillus subtilis FtsA: effects of pH, ionic strength and nucleotides on FtsA assembly

Singh, Parminder, Makde, Ravindra D., Ghosh, Saikat, Asthana, Jayant, Kumar, Vinay and Panda, Dulal (2013). Assembly of Bacillus subtilis FtsA: effects of pH, ionic strength and nucleotides on FtsA assembly. International Journal of Biological Macromolecules, 52, 170-176. doi: 10.1016/j.ijbiomac.2012.09.019

Immuno-PET agents for targeting glioblastoma

Ghosh, S., Huda, P., Fletcher, N., Howard, C., Lu, Y., Campbell, D., Walsh, B. and Thurecht, K. (2022). Immuno-PET agents for targeting glioblastoma. Australian and New Zealand Society of Nuclear Medicine (ANZSNM) 52nd ASM, Brisbane, QLD, Australia, 13–15 May 2022. Richmond, VIC, Australia: John Wiley & Sons.

Novel antibody theranostics for oncology

Ghosh, Saikat (2023). Novel antibody theranostics for oncology. PhD Thesis, Centre for Advanced Imaging, The University of Queensland. doi: 10.14264/43ea7bb