The University of Queensland

Survival for the fittest: guadecitabine in rel/ref AML

Sheehy, Joshua and Lane, Steven W. (2024). Survival for the fittest: guadecitabine in rel/ref AML. Blood Advances, 8 (8), 2018-2019. doi: 10.1182/bloodadvances.2024012569

Australia and New Zealand consensus position statement: use of COVID-19 therapeutics in patients with haematological malignancies

Campbell, Ashlea, Teh, Benjamin, Mulligan, Stephen, Ross, David M., Weinkove, Robert, Gilroy, Nicole, Gangatharan, Shane, Prince, Henry Miles, Szer, Jeff, Trotman, Judith, Lane, Steven, Dickinson, Michael, Quach, Hang, Enjeti, Anoop K., Ku, Matthew, Gregory, Gareth, Hapgood, Gregory, Ho, Phoebe Joy, Cochrane, Tara, Cheah, Chan, Greenwood, Matthew, Latimer, Maya, Berkahn, Leanne, Wight, Joel, Armytage, Tasman, Diamond, Peter, Tam, Constantine S. and Hamad, Nada (2024). Australia and New Zealand consensus position statement: use of COVID-19 therapeutics in patients with haematological malignancies. Internal Medicine Journal, 54 (2), 328-336. doi: 10.1111/imj.16303

Autophagy prevents graft failure during murine Graft versus Host Disease

Lineburg, Katie E, Leveque-El Mouttie, Lucie, Hunter, Christopher R., Le Texier, Laeitia, McGirr, Crystal, Teal, Bianca, Blazar, Bruce R., Lane, Steven W, Hill, Geoffrey R, Levesque, Jean-Pierre and MacDonald, Kelli P.A. (2024). Autophagy prevents graft failure during murine Graft versus Host Disease. Blood Advances, 8 (8), 2032-2043. doi: 10.1182/bloodadvances.2023010972

Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia

Bruedigam, Claudia, Porter, Amy H., Song, Axia, Vroeg in de Wei, Gerjanne, Stoll, Thomas, Straube, Jasmin, Cooper, Leanne, Cheng, Guidan, Kahl, Vivian F. S., Sobinoff, Alexander P., Ling, Victoria Y., Jebaraj, Billy Michael Chelliah, Janardhanan, Yashaswini, Haldar, Rohit, Bray, Laura J., Bullinger, Lars, Heidel, Florian H., Kennedy, Glen A., Hill, Michelle M., Pickett, Hilda A., Abdel-Wahab, Omar, Hartel, Gunter and Lane, Steven W. (2024). Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia. Nature Cancer, 5 (1), 47-65. doi: 10.1038/s43018-023-00653-5

Clearing the way for new therapies in clonal hematopoiesis

Ling, Victoria Y. and Lane, Steven W. (2023). Clearing the way for new therapies in clonal hematopoiesis. Blood Advances, 7 (22), 7151-7152. doi: 10.1182/bloodadvances.2023011728

Genome-wide transcription factor binding maps reveal cell-specific changes in the regulatory architecture of human HSPC

Subramanian, Shruthi, Thoms, Julie A I, Huang, Yizhou, Cornejo Paramo, Carina Paola, Koch, Forrest Charles, Jacquelin, Sebastien, Shen, Sylvie, Song, Emma, Joshi, Swapna, Brownlee, Christopher Peter, Woll, Petter S., Chacon-Fajardo, Diego, Beck, Dominik, Curtis, David J, Yehson, Kenneth, Antonenas, Vicki, O'Brien, Tracey, Trickett, Annette, Powell, Jason A., Lewis, Ian D, Pitson, Stuart M, Gandhi, Maher K., Lane, Steven W, Vafaee, Fatemeh, Wong, Emily, Gottgens, Berthold, Rokny, Hamid, Wong, Jason Wing Hon and Pimanda, John E (2023). Genome-wide transcription factor binding maps reveal cell-specific changes in the regulatory architecture of human HSPC. Blood Journal, 142 (17), 1448-1462. doi: 10.1182/blood.2023021120

Cell fate determinant Llgl1 is required for propagation of acute myeloid leukemia

Eifert, Theresa, Hsu, Chen-Jen, Becker, Alicia L., Graessle, Sarah, Horne, Arik, Bemmann, Franziska, Zhang, Qirui, Heuser, Michael, Vasioukhin, Valeri, Scholl, Sebastian, Hochhaus, Andreas, Siegerist, Florian, Endlich, Nicole, Bullinger, Lars, Lane, Steven W., Haas, Simon, Schnoeder, Tina M. and Heidel, Florian H. (2023). Cell fate determinant Llgl1 is required for propagation of acute myeloid leukemia. Leukemia, 37 (10), 2027-2035. doi: 10.1038/s41375-023-02005-9

The TRIM31-paradox: an unexpected benefit for leukemia stem cells

Straube, Jasmin and Lane, Steven W. (2023). The TRIM31-paradox: an unexpected benefit for leukemia stem cells. Haematologica, 108 (8), 1982-1983. doi: 10.3324/haematol.2022.282622

Characteristics and outcomes of patients with acute promyelocytic leukemia and extreme hyperleukocytosis at presentation

Iland, Harry J, Russell, Nigel H., Dillon, Richard, Schuh, Andre C., Tedjaseputra, Aditya, Wei, Andrew H., Khwaja, Asim, Knapper, Steven, Lane, Steven W, Reynolds, John, McMullin, Mary Frances Frances, Martin, Annalise Maria, Tan, Peter, Taussig, David Christopher C, Wong, Anny, Taper, John M, Fraga, Christina, Kelly, Richard, Tawana, Kiran, Mehta, Priyanka, Mina, Alain, Altman, Jessica K., Mølle, Ingolf, Tauro, Sudhir and Tholouli, Eleni (2023). Characteristics and outcomes of patients with acute promyelocytic leukemia and extreme hyperleukocytosis at presentation. Blood Advances, 7 (11), 2580-2585. doi: 10.1182/bloodadvances.2022007126

Shelter from the cytokine storm in myelofibrosis

Lane, Steven W. (2023). Shelter from the cytokine storm in myelofibrosis. Blood, 141 (20), 2415-2416. doi: 10.1182/blood.2023019779

Culturally adapted motivational interviewing with cognitive behavior therapy and mindfulness-based relapse prevention for substance use disorder in Pakistan (CAMAIB): protocol for a feasibility factorial randomised controlled trial

Asif, Muqaddas, Khoso, Ameer B. B., Husain, M. Ali, Shahzad, Salman, Van Hout, Marie-Claire, Rafiq, Noor-ul-Zaman, Lane, Steven, Chaudhry, Imran Bashir and Husain, Nusrat (2023). Culturally adapted motivational interviewing with cognitive behavior therapy and mindfulness-based relapse prevention for substance use disorder in Pakistan (CAMAIB): protocol for a feasibility factorial randomised controlled trial. Pilot and Feasibility Studies, 9 (1) ARTN 67. doi: 10.1186/s40814-023-01296-0

Oncogenic drivers dictate immune control of acute myeloid leukemia

Austin, Rebecca J., Straube, Jasmin, Halder, Rohit, Janardhanan, Yashaswini, Bruedigam, Claudia, Witkowski, Matthew, Cooper, Leanne, Porter, Amy, Braun, Matthias, Souza-Fonseca-Guimaraes, Fernando, Minnie, Simone A., Cooper, Emily, Jacquelin, Sebastien, Song, Axia, Bald, Tobias, Nakamura, Kyohei, Hill, Geoffrey R., Aifantis, Iannis, Lane, Steven W. and Bywater, Megan J. (2023). Oncogenic drivers dictate immune control of acute myeloid leukemia. Nature Communications, 14 (1) 2155, 1-14. doi: 10.1038/s41467-023-37592-9

Cre recombinase expression cooperates with homozygous FLT3 internal tandem duplication knockin mouse model to induce acute myeloid leukemia

Straube, Jasmin, Eifert, Theresa, Vu, Therese, Janardhanan, Yashaswini, Haldar, Rohit, von Eyss, Björn, Cooper, Leanne, Bruedigam, Claudia, Ling, Victoria Y., Cooper, Emily, Patch, Ann-Marie, Bullinger, Lars, Schnoeder, Tina M., Bywater, Megan, Heidel, Florian H. and Lane, Steven W. (2023). Cre recombinase expression cooperates with homozygous FLT3 internal tandem duplication knockin mouse model to induce acute myeloid leukemia. Leukemia, 37 (4), 741-750. doi: 10.1038/s41375-023-01832-0

Real world molecular characterisation and clonal evolution of acute myeloid leukaemia reveals therapeutic opportunities and challenges

Nelles, Ricky, Seymour, Louise, Richmond, Joshua and Lane, Steven (2023). Real world molecular characterisation and clonal evolution of acute myeloid leukaemia reveals therapeutic opportunities and challenges. Pathology, 55 (1), 64-70. doi: 10.1016/j.pathol.2022.07.019

t(15;17) in acute promyelocytic leukemia

Ling, Victoria Y. and Lane, Steven W. (2023). t(15;17) in acute promyelocytic leukemia. Haematologica, 108 (2), 295-296. doi: 10.3324/haematol.2022.282577

Targeting cell cycle and apoptosis to overcome chemotherapy resistance in acute myeloid leukemia

Ling, Victoria Y., Straube, Jasmin, Godfrey, William, Haldar, Rohit, Janardhanan, Yashaswini, Cooper, Leanne, Bruedigam, Claudia, Cooper, Emily, Tavakoli Shirazi, Paniz, Jacquelin, Sebastien, Tey, Siok-Keen, Baell, Jonathan, Huang, Fei, Jin, Jianwen, Zhao, Yichao, Bullinger, Lars, Bywater, Megan J. and Lane, Steven W. (2023). Targeting cell cycle and apoptosis to overcome chemotherapy resistance in acute myeloid leukemia. Leukemia, 37 (1), 143-153. doi: 10.1038/s41375-022-01755-2

Depletion of exhausted alloreactive T cells enables targeting of stem-like memory T cells to generate tumor-specific immunity

Minnie, Simone A., Waltner, Olivia G., Ensbey, Kathleen S., Nemychenkov, Nicole S., Schmidt, Christine R., Bhise, Shruti S., Legg, Samuel R. W., Campoy, Gabriela, Samson, Luke D., Kuns, Rachel D., Zhou, Ting, Huck, John D., Vuckovic, Slavica, Zamora, Danniel, Yeh, Albert, Spencer, Andrew, Koyama, Motoko, Markey, Kate A., Lane, Steven W., Boeckh, Michael, Ring, Aaron M., Furlan, Scott N. and Hill, Geoffrey R. (2022). Depletion of exhausted alloreactive T cells enables targeting of stem-like memory T cells to generate tumor-specific immunity. Science Immunology, 7 (76) eabo3420, 1-18. doi: 10.1126/sciimmunol.abo3420

Paving the way to improve therapy for Myeloproliferative Neoplasms

Bywater, Megan and Lane, Steven W. (2022). Paving the way to improve therapy for Myeloproliferative Neoplasms. Nature Communications, 13 (1) 5025. doi: 10.1038/s41467-022-32694-2

Epigenetic activation of Plasmacytoid DCs drives IFNAR-dependent therapeutic differentiation of AML

Salmon, Jessica M., Todorovski, Izabela, Stanley, Kym L., Bruedigam, Claudia, Kearney, Conor J., Martelotto, Luciano G., Rossello, Fernando, Semple, Timothy, Arnau, Gisela Mir, Zethoven, Magnus, Bots, Michael, Bjelosevic, Stefan, Cluse, Leonie A., Fraser, Peter J., Litalien, Veronique, Vidacs, Eva, McArthur, Kate, Matthews, Antony Y., Gressier, Elise, De Weerd, Nicole A., Lichte, Jens, Kelly, Madison J., Hogg, Simon J., Hertzog, Paul J., Kats, Lev M., Vervoort, Stephin J., De Carvalho, Daniel D., Scheu, Stefanie, Bedoui, Sammy ... Johnstone, Ricky W. (2022). Epigenetic activation of Plasmacytoid DCs drives IFNAR-dependent therapeutic differentiation of AML. Cancer Discovery, 12 (6), 1560-1579. doi: 10.1158/2159-8290.CD-20-1145

Panel-based gene testing in myelodysplastic/myeloproliferative neoplasm overlap syndromes: Australasian Leukaemia and Lymphoma Group (ALLG) consensus statement

Enjeti, Anoop K., Agarwal, Rishu, Blombery, Piers, Chee, Lynette, Chua, Chong Chyn, Grigg, Andrew, Hamad, Nada, Iland, Harry, Lane, Steven, Perkins, Andrew, Singhal, Deepak, Tate, Courtney, Tiong, Ing Soo and Ross, David M. (2022). Panel-based gene testing in myelodysplastic/myeloproliferative neoplasm overlap syndromes: Australasian Leukaemia and Lymphoma Group (ALLG) consensus statement. Pathology, 54 (4), 389-398. doi: 10.1016/j.pathol.2022.03.002

Better the cure you know: why patients with AML ≥60 years of age should be offered early allogeneic stem cell transplantation

Tey, Siok-Keen and Lane, Steven W (2022). Better the cure you know: why patients with AML ≥60 years of age should be offered early allogeneic stem cell transplantation. Blood Advances, 6 (5), 1619-1622. doi: 10.1182/bloodadvances.2021004829

PLCG1 is required for AML1-ETO leukemia stem cell self-renewal

Schnoeder, Tina M., Schwarzer, Adrian, Jayavelu, Ashok Kumar, Hsu, Chen-Jen, Kirkpatrick, Joanna, Döhner, Konstanze, Perner, Florian, Eifert, Theresa, Huber, Nicolas, Arreba-Tutusaus, Patricia, Dolnik, Anna, Assi, Salam A, Nafria, Monica, Jiang, Lu, Dai, Yu-Ting, Chen, Zhu, Chen, Sai-Juan, Kellaway, Sophie G., Ptasinska, Anetta, Ng, Elizabeth S., Stanley, Edouard G., Elefanty, Andrew G., Buschbeck, Marcus, Bierhoff, Holger, Brodt, Steffen, Matziolis, Georg, Fischer, Klaus-Dieter, Hochhaus, Andreas, Chen, Chun-Wei ... Heidel, Florian (2022). PLCG1 is required for AML1-ETO leukemia stem cell self-renewal. Blood, 139 (7), 1080-1097. doi: 10.1182/blood.2021012778

Optimizing DNA hypomethylating therapy in acute myeloid leukemia and myelodysplastic syndromes

Straube, Jasmin, Lane, Steven W. and Vu, Therese (2021). Optimizing DNA hypomethylating therapy in acute myeloid leukemia and myelodysplastic syndromes. BioEssays, 43 (10) 2100125, 1-14. doi: 10.1002/bies.202100125

Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activity

Weerakoon, Harshi, Straube, Jasmin, Lineburg, Katie, Cooper, Leanne, Lane, Steven, Smith, Corey, Alabbas, Saleh, Begun, Jakob, Miles, John J., Hill, Michelle M. and Lepletier, Ailin (2021). Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activity. Clinical and Translational Immunology, 10 (9) e1334, e1334. doi: 10.1002/cti2.1334

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

Thijssen, Rachel, Diepstraten, Sarah T., Moujalled, Donia, Chew, Edward, Flensburg, Christoffer, Shi, Melissa X., Dengler, Michael A., Litalien, Veronique, MacRaild, Sarah, Chen, Maoshan, Anstee, Natasha S., Reljić, Boris, Gabriel, Sarah S., Djajawi, Tirta M., Riffkin, Chris D., Aubrey, Brandon J., Chang, Catherine, Tai, Lin, Xu, Zhen, Morley, Thomas, Pomilio, Giovanna, Bruedigam, Claudia, Kallies, Axel, Stroud, David A., Bajel, Ashish, Kluck, Ruth M., Lane, Steven W., Schoumacher, Marie, Banquet, Sébastien ... Wei, Andrew H. (2021). Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias. Blood, 137 (20), 2721-2735. doi: 10.1182/blood.2020010167

IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease

Henden, Andrea S., Koyama, Motoko, Robb, Renee J., Forero, Adriana, Kuns, Rachel D., Chang, Karshing, Ensbey, Kathleen S., Varelias, Antiopi, Kazakoff, Stephen H., Waddell, Nicole, Clouston, Andrew D., Giri, Rabina, Begun, Jakob, Blazar, Bruce R., Degli-Esposti, Mariapia A., Kotenko, Sergei V., Lane, Steven W., Bowerman, Kate L., Savan, Ram, Hugenholtz, Philip, Gartlan, Kate H. and Hill, Geoffrey R. (2021). IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease. Blood, 138 (8), 722-737. doi: 10.1182/blood.2020006375

Myeloid somatic mutation panel testing in myeloproliferative neoplasms

Ross, David M., Thomson, Candice, Hamad, Nada, Lane, Steven W., Manos, Kate, Grigg, Andrew P., Guo, Belinda, Erber, Wendy N., Scott, Ashleigh, Viiala, Nick, Chee, Lynette, Latimer, Maya, Tate, Courtney, Grove, Carolyn, Perkins, Andrew C. and Blombery, Piers (2021). Myeloid somatic mutation panel testing in myeloproliferative neoplasms. Pathology, 53 (3), 339-348. doi: 10.1016/j.pathol.2021.01.003

A knockout combination for MPN stem cells

Bywater, Megan and Lane, Steven W. (2021). A knockout combination for MPN stem cells. Journal of Experimental Medicine, 218 (2) e20201884. doi: 10.1084/JEM.20201884

Intravascular large B-cell lymphoma presenting with extensive pulmonary embolism

Wong, Philip, Chambers, Daniel, Godbolt, David and Lane, Steven W. (2021). Intravascular large B-cell lymphoma presenting with extensive pulmonary embolism. British Journal of Haematology, 192 (4), 677-677. doi: 10.1111/bjh.17182

Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms

Jayavelu, Ashok Kumar, Schnöder, Tina M., Perner, Florian, Herzog, Carolin, Meiler, Arno, Krishnamoorthy, Gurumoorthy, Huber, Nicolas, Mohr, Juliane, Edelmann-Stephan, Bärbel, Austin, Rebecca, Brandt, Sabine, Palandri, Francesca, Schröder, Nicolas, Isermann, Berend, Edlich, Frank, Sinha, Amit U., Ungelenk, Martin, Hübner, Christian A., Zeiser, Robert, Rahmig, Susann, Waskow, Claudia, Coldham, Iain, Ernst, Thomas, Hochhaus, Andreas, Jilg, Stefanie, Jost, Philipp J., Mullally, Ann, Bullinger, Lars, Mertens, Peter R. ... Heidel, Florian H. (2020). Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms. Nature, 588 (7836), 157-163. doi: 10.1038/s41586-020-2968-3

Murine models of myelofibrosis

Jacquelin, Sebastien, Kramer, Frederike, Mullally, Ann and Lane, Steven W. (2020). Murine models of myelofibrosis. Cancers, 12 (9) 2381, 1-22. doi: 10.3390/cancers12092381

MPN: The Molecular Drivers of Disease Initiation, Progression and Transformation and their Effect on Treatment

Grabek, Julian, Straube, Jasmin, Bywater, Megan and Lane, Steven W. (2020). MPN: The Molecular Drivers of Disease Initiation, Progression and Transformation and their Effect on Treatment. Cells, 9 (8) 1912, 1901. doi: 10.3390/cells9081901

Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia

Vu, Therese, Straube, Jasmin, Porter, Amy H., Bywater, Megan, Song, Axia, Ling, Victoria, Cooper, Leanne, Pali, Gabor, Bruedigam, Claudia, Jacquelin, Sebastien, Green, Joanne, Magor, Graham, Perkins, Andrew, Chalk, Alistair M., Walkley, Carl R., Heidel, Florian H., Mukhopadhyay, Pamela, Cloonan, Nicole, Gröschel, Stefan, Mallm, Jan-Philipp, Fröhling, Stefan, Scholl, Claudia and Lane, Steven W. (2020). Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia. Nature Communications, 11 (1) 3021, 3021. doi: 10.1038/s41467-020-16840-2

Managing haematology and oncology patients during the COVID-19 pandemic: interim consensus guidance

Weinkove, Robert, McQuilten, Zoe K, Adler, Jonathan, Agar, Meera R, Blyth, Emily, Cheng, Allen C, Conyers, Rachel, Haeusler, Gabrielle M, Hardie, Claire, Jackson, Christopher, Lane, Steven W, Middlemiss, Tom, Mollee, Peter, Mulligan, Stephen P, Ritchie, David, Ruka, Myra, Solomon, Benjamin, Szer, Jeffrey, Thursky, Karin A, Wood, Erica M, Worth, Leon J, Yong, Michelle K, Slavin, Monica A and Teh, Benjamin W (2020). Managing haematology and oncology patients during the COVID-19 pandemic: interim consensus guidance. Medical Journal of Australia, 212 (10) mja2.50607, 481-489. doi: 10.5694/mja2.50607

Type I interferons suppress anti-parasitic immunity and can be targeted to improve treatment of visceral leishmaniasis

Kumar, Rajiv, Bunn, Patrick T., Singh, Siddharth Sankar, Ng, Susanna S., Montes de Oca, Marcela, De Labastida Rivera, Fabian, Chauhan, Shashi Bhushan, Singh, Neetu, Faleiro, Rebecca J., Edwards, Chelsea L., Frame, Teija C.M., Sheel, Meru, Austin, Rebecca J., Lane, Steven W., Bald, Tobias, Smyth, Mark J., Hill, Geoffrey.R., Best, Shannon E., Haque, Ashraful, Corvino, Dillon, Waddell, Nic, Koufariotis, Lambross, Mukhopadhay, Pamela, Rai, Madhukar, Chakravarty, Jaya, Singh, Om Prakash, Sacks, David, Nylen, Susanne, Uzonna, Jude ... Engwerda, Christian R. (2020). Type I interferons suppress anti-parasitic immunity and can be targeted to improve treatment of visceral leishmaniasis. Cell Reports, 30 (8), 2512-2525.e9. doi: 10.1016/j.celrep.2020.01.099

Mapping functional susceptibilities in AML

Lane, Steven and Henden, Andrea (2020). Mapping functional susceptibilities in AML. The Hematologist, 17 (1). doi: 10.1182/hem.v17.1.10162

Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory

Soon, Megan S. F., Lee, Hyun Jae, Engel, Jessica A., Straube, Jasmin, Thomas, Bryce S., Pernold, Clara P. S., Clarke, Lachlan S., Laohamonthonkul, Pawat, Haldar, Rohit N., Williams, Cameron G., Lansink, Lianne I. M., Moreira, Marcela L., Bramhall, Michael, Koufariotis, Lambros T., Wood, Scott, Chen, Xi, James, Kylie R., Lönnberg, Tapio, Lane, Steven W., Belz, Gabrielle T., Engwerda, Christian R., Khoury, David S., Davenport, Miles P., Svensson, Valentine, Teichmann, Sarah A. and Haque, Ashraful (2020). Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory. Nature Immunology, 21 (12), 1597-1610. doi: 10.1038/s41590-020-0800-8

Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populations

Austin, Rebecca J., Straube, Jasmin, Bruedigam, Claudia, Pali, Gabor, Jacquelin, Sebastien, Vu, Therese, Green, Joanne, Gräsel, Julius, Lansink, Lianne, Cooper, Leanne, Lee, Shin-Jye, Chen, Nien-Tsu, Lee, Chung-Wei, Haque, Ashraful, Heidel, Florian H., D’Andrea, Richard, Hill, Geoff R., Mullally, Ann, Milsom, Michael D., Bywater, Megan and Lane, Steven W. (2019). Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populations. Leukemia, 34 (4), 1075-1089. doi: 10.1038/s41375-019-0638-y

Inflammation in del(20q): a MST opportunity?

Lane, Steven W. (2019). Inflammation in del(20q): a MST opportunity?. Blood, 134 (20), 1685-1686. doi: 10.1182/blood.2019003028

Acute promyelocytic leukaemia with marked symptomatic hyperleucocytosis: images in haematology

Yuan, Yin, Mediwake, Heshani, Bokhari, Syed W., Holley, Anthony and Lane, Steven W. (2019). Acute promyelocytic leukaemia with marked symptomatic hyperleucocytosis: images in haematology. British Journal of Haematology, 186 (5), 649-649. doi: 10.1111/bjh.16016

Attenuated acceleration to leukemia after Ezh2 loss in Nup98-HoxD13 (NHD13) myelodysplastic syndrome

Ling, Victoria Y., Saw, Jesslyn, Tremblay, Cedric S., Sonderegger, Stefan E., Toulmin, Emma, Boyle, Jacqueline, Chiu, Sung Kai, Lane, Steven W., Ting, Stephen B. and Curtis, David J. (2019). Attenuated acceleration to leukemia after Ezh2 loss in Nup98-HoxD13 (NHD13) myelodysplastic syndrome. HemaSphere, 3 (4) e277, e277. doi: 10.1097/HS9.0000000000000277

Recommendations for the use of pegylated interferon-α in the treatment of classical myeloproliferative neoplasms

Forsyth, Cecily J., Chan, Wai-Hoong, Grigg, Andrew P., Cook, Nathalie C., Lane, Steven W., Burbury, Kate L., Perkins, Andrew C. and Ross, David M. (2019). Recommendations for the use of pegylated interferon-α in the treatment of classical myeloproliferative neoplasms. Internal Medicine Journal, 49 (8), 948-954. doi: 10.1111/imj.14154

Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation

Jacquelin, Sebastien, Straube, Jasmin, Cooper, Leanne, Vu, Therese, Song, Axia, Bywater, Megan, Baxter, Eva, Heidecker, Matthew, Wackrow, Brad, Porter, Amy, Ling, Victoria, Green, Joanne, Austin, Rebecca, Kazakoff, Stephen, Waddell, Nicola, Hesson, Luke B., Pimanda, John E., Stegelmann, Frank, Bullinger, Lars, Döhner, Konstanze, Rampal, Raajit K., Heckl, Dirk, Hill, Geoffrey R. and Lane, Steven W. (2018). Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation. Blood, 132 (26), blood-2018. doi: 10.1182/blood-2018-04-846220

Recipient mucosal-associated invariant T cells control graft-versus-host-disease within the colon

Varelias, Antiopi, Bunting, Mark, Ormerod, Kate, Koyama, Motoko, Olver, Stuart, Straube, Jasmin, Kuns, Rachel, Robb, Renee, Henden, Andrea, Cooper, Leanne, Lachner, Nancy, Gartlan, Kate, Lantz, Olivier J., Kjer-Nielsen, Lars, Mak, Jeffrey, Fairlie, David, Clouston, Andrew, McCluskey, James, Rossjohn, Jamie, Lane, Steven, Hugenholtz, Phil and Hill, Geoff (2018). Recipient mucosal-associated invariant T cells control graft-versus-host-disease within the colon. The Journal of Immunology, 200 (1_Supplement), 55.15-55.15. doi: 10.4049/jimmunol.200.supp.55.15

Recipient mucosal-associated invariant T cells control GVHD within the colon

Varelias, Antiopi, Bunting, Mark D., Ormerod, Kate L., Koyama, Motoko, Olver, Stuart D., Straube, Jasmin, Kuns, Rachel D., Robb, Renee J., Henden, Andrea S., Cooper, Leanne, Lachner, Nancy, Gartlan, Kate H., Lantz, Olivier, Kjer-Nielsen, Lars, Mak, Jeffrey Y. W., Fairlie, David P., Clouston, Andrew D., McCluskey, James, Rossjohn, Jamie, Lane, Steven W., Hugenholtz, Philip and Hill, Geoffrey R. (2018). Recipient mucosal-associated invariant T cells control GVHD within the colon. Journal of Clinical Investigation, 128 (5), 1919-1936. doi: 10.1172/JCI91646

Conventional dendritic cells are required for the cross-presentation of leukemia-specific antigen in a model of AML relapse post-BMT

Markey, Kate A., Gartlan, Kate H., Kuns, Rachel D., Lane, Steven W. and Hill, Geoffrey R. (2018). Conventional dendritic cells are required for the cross-presentation of leukemia-specific antigen in a model of AML relapse post-BMT. Bone Marrow Transplantation, 53 (6), 800-803. doi: 10.1038/s41409-018-0148-y

The impact of age, NPM1, and FLT3 allelic ratio in patients with acute myeloid leukemia

Straube, Jasmin, Ling, Victoria Y, Hill, Geoffrey R and Lane, Steven W (2018). The impact of age, NPM1, and FLT3 allelic ratio in patients with acute myeloid leukemia. Blood, 131 (10), 1148-1153. doi: 10.1182/blood-2017-09-807438

Oncogenic JAK2causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms

Prestipino, Alessandro, Emhardt, Alica J., Aumann, Konrad, O'Sullivan, David, Gorantla, Sivahari P., Duquesne, Sandra, Melchinger, Wolfgang, Braun, Lukas, Vuckovic, Slavica, Boerries, Melanie, Busch, Hauke, Halbach, Sebastian, Pennisi, Sandra, Poggio, Teresa, Apostolova, Petya, Veratti, Pia, Hettich, Michael, Niedermann, Gabriele, Bartholomä, Mark, Shoumariyeh, Khalid, Jutzi, Jonas S., Wehrle, Julius, Dierks, Christine, Becker, Heiko, Schmitt-Graeff, Annette, Follo, Marie, Pfeifer, Dietmar, Rohr, Jan, Fuchs, Sebastian ... Zeiser, Robert (2018). Oncogenic JAK2causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms. Science Translational Medicine, 10 (429) eaam7729, eaam7729. doi: 10.1126/scitranslmed.aam7729

IFN regulatory factor 3 balances Th1 and T follicular helper immunity during nonlethal blood-stage Plasmodium infection

James, Kylie R., Soon, Megan S. F., Sebina, Ismail, Fernandez-Ruiz, Daniel, Davey, Gayle, Liligeto, Urijah N., Nair, Arya Sheela, Fogg, Lily G., Edwards, Chelsea L., Best, Shannon E., Lansink, Lianne I. M., Schroder, Kate, Wilson, Jane A. C., Austin, Rebecca, Suhrbier, Andreas, Lane, Steven W., Hill, Geoffrey R., Engwerda, Christian R., Heath, William R. and Haque, Ashraful (2018). IFN regulatory factor 3 balances Th1 and T follicular helper immunity during nonlethal blood-stage Plasmodium infection. Journal of Immunology, 200 (4), 1443-1456. doi: 10.4049/jimmunol.1700782

Flt-3L expansion of recipient CD8α+ dendritic cells deletes alloreactive donor T cells and represents an alternative to post-transplant cyclophosphamide for the prevention of GVHD

Markey, Kate A., Kuns, Rachel D., Browne, Daniel J., Gartlan, Kate H., Robb, Renee J., Martins, J. Paulo, Henden, Andrea S., Minnie, Simone A., Cheong, Melody, Koyama, Motoko, Smyth, Mark J., Steptoe, Raymond J., Belz, Gabrielle, Brocker, Thomas, Degli-Esposti, Mariapia A., Lane, Steven W. and Hill, Geoffrey R. (2018). Flt-3L expansion of recipient CD8α+ dendritic cells deletes alloreactive donor T cells and represents an alternative to post-transplant cyclophosphamide for the prevention of GVHD. Clinical Cancer Research, 24 (7), 1604-1616. doi: 10.1158/1078-0432.CCR-17-2148

Differential effects on gene transcription and hematopoietic differentiation correlate with GATA2 mutant disease phenotypes

Chong, C. -E., Venugopal, P., Stokes, P. H., Lee, Y. K., Brautigan, P. J., Yeung, D. T. O., Babic, M., Engler, G. A., Lane, S. W., Klingler-Hoffmann, M., Matthews, J. M., D'Andrea, R. J., Brown, A. L., Hahn, C. N. and Scott, H. S. (2018). Differential effects on gene transcription and hematopoietic differentiation correlate with GATA2 mutant disease phenotypes. Leukemia, 32 (1), 194-202. doi: 10.1038/leu.2017.196

Clinical and molecular categorization of progressive, adult-onset cutaneous mastocytosis

Tate, Courtney, Tang, Fiona, Lane, Steven W. and Seymour, Louise (2017). Clinical and molecular categorization of progressive, adult-onset cutaneous mastocytosis. JAAD Case Reports, 4 (1), 30-32. doi: 10.1016/j.jdcr.2017.09.038

Acute myeloid leukemia stem cell function is preserved in the absence of autophagy

Porter, Amy H., Leveque-El Mouttie, Lucie, Vu, Therese, Bruedigam, Claudia, Sutton, Joanne, Jacquelin, Sebastien, Hill, Geoffrey R., MacDonald, Kelli P. A. and Lane, Steven W. (2017). Acute myeloid leukemia stem cell function is preserved in the absence of autophagy. Haematologica, 102 (9), E344-E347. doi: 10.3324/haematol.2017.166389

Hacking the stem cell niche

Lane, Steven W. and Heidel, Florian H. (2017). Hacking the stem cell niche. Blood, 129 (22), 2951-2952. doi: 10.1182/blood-2017-04-777789

Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress

Shi, Wei, Vu, Therese, Boucher, Didier, Biernacka, Anna, Nde, Jules, Pandita, Raj K., Straube, Jasmin, Boyle, Glen M., Al-Ejeh, Fares, Nag, Purba, Jeffery, Jessie, Harris, Janelle L., Bain, Amanda L., Grzelak, Marta, Skrzypczak, Magdalena, Mitra, Abhishek, Dojer, Norbert, Crosetto, Nicola, Cloonan, Nicole, Becherel, Olivier J., Finnie, John, Skaar, Jeffrey R., Walkley, Carl R., Pandita, Tej K., Rowicka, Maga, Ginalski, Krzysztof, Lane, Steven W. and Khanna, Kum Kum (2017). Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress. Blood, 129 (18), 2479-2492. doi: 10.1182/blood-2016-06-725093

Global prevalence of carbapenem resistance in neutropenic patients and association with mortality and carbapenem use: systematic review and meta-analysis

Righi, Elda, Peri, Anna Maria, Harris, Patrick N. A., Wailan, Alexander M., Liborio, Mariana, Lane, Steven W. and Paterson, David L. (2017). Global prevalence of carbapenem resistance in neutropenic patients and association with mortality and carbapenem use: systematic review and meta-analysis. Journal of Antimicrobial Chemotherapy, 72 (3), 668-677. doi: 10.1093/jac/dkw459

GVHD prevents NK-cell-dependent leukemia and virus-specific innate immunity

Bunting, Mark D., Varelias, Antiopi, Souza-Fonseca-Guimaraes, Fernando, Schuster, Iona S., Lineburg, Katie E., Kuns, Rachel D., Fleming, Peter, Locke, Kelly R., Huntington, Nicholas D., Blazar, Bruce R., Lane, Steven W., Tey, Siok-Keen, MacDonald, Kelli P. A., Smyth, Mark J., Degli-Esposti, Mariapia A. and Hill, Geoffrey R. (2017). GVHD prevents NK-cell-dependent leukemia and virus-specific innate immunity. Blood, 129 (5), 630-642. doi: 10.1182/blood-2016-08-734020

An unhealthy diet: making sense of a fatty niche for leukemia stem cells

Jacquelin, Sebastien, Dishington, Emma J. and Lane, Steven W. (2016). An unhealthy diet: making sense of a fatty niche for leukemia stem cells. Translational Cancer Research, 5 (S4), S878-S881. doi: 10.21037/tcr.2016.10.43

Harnessing the immune system in acute myeloid leukaemia

Austin, Rebecca, Smyth, Mark J. and Lane, Steven W. (2016). Harnessing the immune system in acute myeloid leukaemia. Critical Reviews in Oncology/Hematology, 103, 62-77. doi: 10.1016/j.critrevonc.2016.04.020

Telomerase in hematologic malignancies

Bruedigam, Claudia and Lane, Steven W. (2016). Telomerase in hematologic malignancies. Current Opinion in Hematology, 23 (4), 346-353. doi: 10.1097/MOH.0000000000000252

Analysis of telomerase target gene expression effects from murine models in patient cohorts by homology translation and random survival forest modeling

Bagger, Frederik Otzen, Bruedigam, Claudia and Lane, Steven W. (2016). Analysis of telomerase target gene expression effects from murine models in patient cohorts by homology translation and random survival forest modeling. Genomics Data, 7, 275-280. doi: 10.1016/j.gdata.2016.01.014

Jak2V617F driven myeloproliferative neoplasm occurs independently of interleukin-3 receptor beta common signalling

Vu, Therese, Austin, Rebecca, Kuhn, Catherine Paine, Bruedigam, Claudia, Song, Axia, Guignes, Solene, Jacquelin, Sebastien, Ramshaw, Hayley S., Hill, Geoffrey R., Lopez, Angel F. and Lane, Steven W. (2016). Jak2V617F driven myeloproliferative neoplasm occurs independently of interleukin-3 receptor beta common signalling. Haematologica, 101 (3), E77-E80. doi: 10.3324/haematol.2015.136705

Increased risk of melanoma in patients with chronic lymphocytic leukaemia: systematic review and meta-analysis of cohort studies

Olsen, Catherine M., Lane, Steven W. and Green, Adèle C. (2015). Increased risk of melanoma in patients with chronic lymphocytic leukaemia: systematic review and meta-analysis of cohort studies. Melanoma Research, 26 (2), 188-194. doi: 10.1097/CMR.0000000000000219

BET inhibitor resistance emerges from leukaemia stem cells

Fong, Chun Yew, Gilan, Omer, Lam, Enid Y.N., Rubin, Alan F., Ftouni, Sarah, Tyler, Dean, Stanley, Kym, Sinha, Devbarna, Yeh, Paul, Morison, Jessica, Giotopoulos, George, Lugo, Dave, Jeffrey, Philip, Lee, Stanley Chun-Wei, Carpenter, Christopher, Gregory, Richard, Ramsay, Robert G., Lane, Steven W., Abdel-Wahab, Omar, Kouzarides, Tony, Johnstone, Ricky W., Dawson, Sarah-Jane, Huntly, Brian J.P., Prinjha, Rab K., Papenfuss, Anthony T. and Dawson, Mark A. (2015). BET inhibitor resistance emerges from leukaemia stem cells. Nature, 525 (7570), 538-542. doi: 10.1038/nature14888

Tc17 cells are a proinflammatory, plastic lineage of pathogenic CD8⁺ T cells that induce GVHD without antileukemic effects

Gartlan, Kate H., Markey, Kate A., Varelias, Antiopi, Bunting, Mark D., Koyama, Motoko, Kuns, Rachel D., Raffelt, Neil C., Olver, Stuart D., Lineburg, Katie E., Cheong, Melody, Teal, Bianca E., Lor, Mary, Comerford, Iain, Teng, Michele W. L., Smyth, Mark J., McCluskey, James, Rossjohn, Jamie, Stockinger, Brigitta, Boyle, Glen M., Lane, Steven W., Clouston, Andrew D., McColl, Shaun R., MacDonald, Kelli P. A. and Hill, Geoffrey R. (2015). Tc17 cells are a proinflammatory, plastic lineage of pathogenic CD8+ T cells that induce GVHD without antileukemic effects. Blood, 126 (13), 1609-1620. doi: 10.1182/blood-2015-01-622662

Ssb2/Nabp1 is dispensable for thymic maturation, male fertility, and DNA repair in mice

Boucher, Didier, Vu, Therese, Bain, Amanda L., Tagliaro-Jahns, Marina, Shi, Wei, Lane, Steven W. and Khanna, Kum Kum (2015). Ssb2/Nabp1 is dispensable for thymic maturation, male fertility, and DNA repair in mice. FASEB Journal, 29 (8), 3326-3334. doi: 10.1096/fj.14-269944

EphA2 Is a Therapy Target in EphA2-Positive Leukemias but Is Not Essential for Normal Hematopoiesis or Leukemia.

Charmsaz, Sara, Beckett, Kirrilee, Smith, Fiona M., Bruedigam, Claudia, Moore, Andrew S., Al-Ejeh, Fares, Lane, Steven W. and Boyd, Andrew W. (2015). EphA2 Is a Therapy Target in EphA2-Positive Leukemias but Is Not Essential for Normal Hematopoiesis or Leukemia.. PLoS One, 10 (6) e0130692, e0130692-e0130692. doi: 10.1371/journal.pone.0130692

Autophagy is required for stem cell mobilization by G-CSF

Leveque-El Mouttie, Lucie, Vu, Therese, Lineburg, Katie E., Kuns, Rachel D., Bagger, Frederik O., Teal, Bianca E., Lor, Mary, Boyle, Glen M., Bruedigam, Claudia, Mintern, Justine D., Hill, Geoffrey R., MacDonald, Kelli P. A. and Lane, Steven W. (2015). Autophagy is required for stem cell mobilization by G-CSF. Blood, 125 (19), 2933-2936. doi: 10.1182/blood-2014-03-562660

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

Walter, Dagmar, Lier, Amelie, Geiselhart, Anja, Thalheimer, Frederic B., Huntscha, Sina, Sobotta, Mirko C., Moehrle, Bettina, Brocks, David, Bayindir, Irem, Kaschutnig, Paul, Muedder, Katja, Klein, Corinna, Jauch, Anna, Schroeder, Timm, Geiger, Hartmut, Dick, Tobias, Holland-Letz, Tim, Schmezer, Peter, Lane, Steven W., Rieger, Michael A., Essers, Marieke A. G., Williams, David A., Trumpp, Andreas and Milsom, Michael D. (2015). Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells. Nature, 520 (7548), 549-552. doi: 10.1038/nature14131

A critical role for murine transferrin receptor 2 in erythropoiesis during iron restriction

Wallace, Daniel F., Secondes, Eriza S., Rishi, Gautam, Ostini, Lesa, McDonald, Cameron J., Lane, Steven W., Vu, Therese, Hooper, John D., Velasco, Gloria, Ramsay, Andrew J., Lopez-Otin, Carlos and Subramaniam, V. Nathan (2015). A critical role for murine transferrin receptor 2 in erythropoiesis during iron restriction. British Journal of Haematology, 168 (6), 891-901. doi: 10.1111/bjh.13225

Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy

Bruedigam, C., Bagger, F.O., Heidel, F.H., Paine, Kuhn C., Guignes, S., Song, A., Austin, R., Vu, T., Lee, E., Riyat, S., Moore, A.S., Lock, R.B., Bullinger, L., Hill, G.R., Armstrong, S.A., Williams, D.A. and Lane, S.W. (2014). Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy. Cell Stem Cell, 15 (6), 775-790. doi: 10.1016/j.stem.2014.11.010

Hit the spleen, JAK!

Lane, Steven W. and Mullally, Ann (2014). Hit the spleen, JAK!. Blood, 124 (19), 2898-2900. doi: 10.1182/blood-2014-09-600635

Modulating the stem cell niche for tissue regeneration

Lane, Steven W., Williams, David A. and Watt, Fiona M. (2014). Modulating the stem cell niche for tissue regeneration. Nature Biotechnology, 32 (8), 795-803. doi: 10.1038/nbt.2978

Sorafenib priming may augment salvage chemotherapy in relapsed and refractory FLT3-ITD-positive acute myeloid leukemia

Cummins, K. D., Jane, S. M., Ninkovic, S., Bazargan, A., Filshie, R., Sutrave, G., Hertzberg, M., Scott, A., Lane, S., Yannakou, C. K., Ritchie, D., D'Rozario, J., Black, J., Bavishi, K. and Wei, A. (2014). Sorafenib priming may augment salvage chemotherapy in relapsed and refractory FLT3-ITD-positive acute myeloid leukemia. Blood Cancer Journal, 4 (e237) e237, 1-2. doi: 10.1038/bcj.2014.59

The Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS

Lane, S. W., Sykes, S. M., Al-Shahrour, F., Shterental, S., Paktinat, M., Lo Celso, C., Jesneck, J. L., Ebert, B. L., Williams, D. A. and Gilliland, D. Gary (2014). The Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS. Blood, 123 (2), 301-301. doi: 10.1182/blood-2013-11-540047

The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML

Heidel, Florian H., Bullinger, Lars, Arreba-Tutusaus, Patricia, Wang, Zhu, Gaebel, Julia, Hirt, Carsten, Niederwieser, Dietger, Lane, Steven W., Doehner, Konstanze, Vasioukhin, Valera, Fischer, Thomas and Armstrong, Scott A. (2013). The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML. Journal of Experimental Medicine, 210 (1), 15-22. doi: 10.1084/jem.20120596

Induced regulatory T cells promote tolerance when stabilized by rapamycin and IL-2 in vivo

Zhang, Ping, Tey, Siok-Keen, Koyama, Motoko, Kuns, Rachel D., Olver, Stuart D., Lineburg, Katie E., Lor, Mary, Teal, Bianca E., Raffelt, Neil C., Raju, Jyothy, Leveque, Lucie, Markey, Kate A., Varelias, Antiopi, Clouston, Andrew D., Lane, Steven W., Macdonald, Kelli P. A. and Hill, Geoffrey R. (2013). Induced regulatory T cells promote tolerance when stabilized by rapamycin and IL-2 in vivo. Journal of Immunology, 191 (10), 5291-5303. doi: 10.4049/jimmunol.1301181

Deciphering hematopoietic stem cells in their niches: a critical appraisal of genetic models, lineage tracing, and imaging strategies

Joseph, Chacko, Quach, Julie M., Walkley, Carl R., Lane, Steven W., Lo Celso, Cristina and Purton, Louise E. (2013). Deciphering hematopoietic stem cells in their niches: a critical appraisal of genetic models, lineage tracing, and imaging strategies. Cell Stem Cell, 13 (5), 520-533. doi: 10.1016/j.stem.2013.10.010

Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-alpha in a murine model of polycythemia vera

Mullally, Ann, Bruedigam, Claudia, Poveromo, Luke, Heidel, Florian H., Purdon, Amy, Vu, Therese, Austin, Rebecca, Heckl, Dirk, Breyfogle, Lawrence J., Kuhn, Catherine Paine, Kalaitzidis, Demetrios, Armstrong, Scott A., Williams, David A., Hill, Geoff R., Ebert, Benjamin L. and Lane, Steven W. (2013). Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-alpha in a murine model of polycythemia vera. Blood, 121 (18), 3692-3702. doi: 10.1182/blood-2012-05-432989

Jak2V617F myeloproliferative neoplasm stem cells and interferon-alpha

Lane, Steven W. and Mullally, Ann (2013). Jak2V617F myeloproliferative neoplasm stem cells and interferon-alpha. Oncotarget, 4 (4), 500-501. doi: 10.18632/oncotarget.986

The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment

Dorrance, Adrienne M., De Vita, Serena, Radu, Maria, Reddy, Pavankumar N. G., McGuinness, Meaghan K., Harris, Chad E., Mathieu, Ronald, Lane, Steven W., Kosoff, Rachelle, Milsom, Michael D., Chernoff, Jonathan and Williams, David A. (2013). The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment. Blood, 121 (13), 2474-2482. doi: 10.1182/blood-2012-10-460709

Tolerance induction with gene-modified stem cells and immune-preserving conditioning in primed mice: restricting antigen to differentiated antigen-presenting cells permits efficacy

Coleman, Miranda A., Bridge, Jennifer A., Lane, Steven W., Dixon, Chantelle M., Hill, Geoffrey R., Wells, James W., Thomas, Ranjeny and Steptoe, Raymond J. (2013). Tolerance induction with gene-modified stem cells and immune-preserving conditioning in primed mice: restricting antigen to differentiated antigen-presenting cells permits efficacy. Blood, 121 (6), 1049-1058. doi: 10.1182/blood-2012-06-434100

CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPARγ signaling

Faber, Katrin, Bullinger, Lars, Ragu, Christine, Garding, Angela, Mertens, Daniel, Miller, Christina, Martin, Daniela, Walcher, Daniel, Doehner, Konstanze, Doehner, Hartmut, Claus, Rainer, Plass, Christoph, Sykes, Stephen M., Lane, Steven W., Scholl, Claudia and Froehling, Stefan (2013). CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPARγ signaling. Journal of Clinical Investigation, 123 (1), 299-314. doi: 10.1172/JCI64745

Myeloproliferative Neoplasm Animal Models

Mullally, Ann, Lane, Steven W., Brumme, Kristina and Ebert, Benjamin L. (2012). Myeloproliferative Neoplasm Animal Models. Hematology/Oncology Clinics of North America, 26 (5), 1065-1081. doi: 10.1016/j.hoc.2012.07.007

mTOR complex 1 plays critical roles in hematopoiesis and pten-loss-evoked leukemogenesis

Kalaitzidis, Demetrios, Sykes, Stephen M., Wang, Zhu, Punt, Natalie, Tang, Yuefeng, Ragu, Christine, Sinha, Amit U., Lane, Steven W., Souza, Amanda L., Clish, Clary B., Anastasiou, Dimitrios, Gilliland, D. Gary, Scadden, David T., Guertin, David A. and Armstrong, Scott A. (2012). mTOR complex 1 plays critical roles in hematopoiesis and pten-loss-evoked leukemogenesis. Cell Stem Cell, 11 (3), 429-439. doi: 10.1016/j.stem.2012.06.009

Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia vera

Mullally, Ann, Poveromo, Luke, Schneider, Rebekka K., Al-Shahrour, Fatima, Lane, Steven W. and Ebert, Benjamin L. (2012). Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia vera. Blood, 120 (1), 166-172. doi: 10.1182/blood-2012-01-402396

Valproic acid combined with cytosine arabinoside in elderly patients with acute myeloid leukemia has in vitro but limited clinical activity

Lane, Steven, Gill, Devinder, McMillan, Nigel A. J., Saunders, Nicholas, Murphy, Rachel, Spurr, Terrence, Keane, Colm, Fan, Helen Mar and Mollee, Peter (2012). Valproic acid combined with cytosine arabinoside in elderly patients with acute myeloid leukemia has in vitro but limited clinical activity. Leukemia & Lymphoma, 53 (6), 1077-1083. doi: 10.3109/10428194.2011.642302

Genetic and pharmacologic inhibition of beta-catenin targets imatinib-resistant leukemia stem cells in CML

Heidel, Florian H., Bullinger, Lars, Feng, Zhaohui, Wang, Zhu, Neff, Tobias A., Stein, Lauren, Kalaitzidis, Demetrios, Lane, Steve W. and Armstrong, Scott A. (2012). Genetic and pharmacologic inhibition of beta-catenin targets imatinib-resistant leukemia stem cells in CML. Cell Stem Cell, 10 (4), 412-424. doi: 10.1016/j.stem.2012.02.017

WT1 expression as a marker of minimal residual disease predicts outcome in acute myeloid leukemia when measured post-consolidation

Gray, James X., McMillen, Lyle, Mollee, Peter, Paul, Sanjoy, Lane, Steven, Bird, Robert, Gill, Devinder, Saal, Russell and Marlton, Paula (2012). WT1 expression as a marker of minimal residual disease predicts outcome in acute myeloid leukemia when measured post-consolidation. Leukemia Research, 36 (4), 453-458. doi: 10.1016/j.leukres.2011.09.005

Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic development

Lane, Steven W., De Vita, Serena, Alexander, Kylie A., Karaman, Ruchan, Milsom, Michael D., Dorrance, Adrienne M., Purdon, Amy, Louis, Leeann, Bouxsein, Mary L. and Williams, David A. (2012). Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic development. Blood, 119 (3), 736-744. doi: 10.1182/blood-2011-07-368753

Bad to the bone

Lane, Steven W. (2012). Bad to the bone. Blood, 119 (2), 323-325. doi: 10.1182/blood-2011-10-383901

Construction and Crystal Structure of Recombinant STNV Capsids

Lane, Stephen W., Dennis, Caitriona A., Lane, Claire L., Trinh, Chi H., Rizkallah, Pierre J., Stockley, Peter G. and Phillips, Simon E. V. (2011). Construction and Crystal Structure of Recombinant STNV Capsids. Journal of Molecular Biology, 413 (1), 41-50. doi: 10.1016/j.jmb.2011.07.062

Degenerate RNA packaging signals in the genome of satellite tobacco necrosis virus: Implications for the assembly of a T = 1 capsid

Bunka, David H. J., Lane, Stephen W., Lane, Claire L., Dykeman, Eric C., Ford, Robert J., Barker, Amy M., Twarock, Reidun, Phillips, Simon E. V. and Stockley, Peter G. (2011). Degenerate RNA packaging signals in the genome of satellite tobacco necrosis virus: Implications for the assembly of a T = 1 capsid. Journal of Molecular Biology, 413 (1), 51-65. doi: 10.1016/j.jmb.2011.07.063

AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias

Sykes, Stephen M., Lane, Steven W., Bullinger, Lars, Kalaitzidis, Demetrios, Yusuf, Rushdia, Saez, Borja, Ferraro, Francesca, Mercier, Francois, Singh, Harshabad, Brumme, Kristina M., Acharya, Sanket S., Schoell, Claudia, Tothova, Zuzana, Attar, Eyal C., Froehling, Stefan, DePinho, Ronald A., Armstrong, Scott A., Gilliland, D. Gary and Scadden, David T. (2011). AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias. Cell, 146 (5), 697-708. doi: 10.1016/j.cell.2011.07.032

Differential niche and Wnt requirements during acute myeloid leukemia progression

Lane, Steven W., Wang, Yingzi J., Lo Celso, Cristina, Ragu, Christine, Bullinger, Lars, Sykes, Stephen M., Ferraro, Francesca, Shterental, Sebastian, Lin, Charles P., Gilliland, D. Gary, Scadden, David T., Armstrong, Scott A. and Williams, David A. (2011). Differential niche and Wnt requirements during acute myeloid leukemia progression. Blood, 118 (10), 2849-2856. doi: 10.1182/blood-2011-03-345165

CNS Relapse in Acute Promyeloctyic Leukemia

Housman, Elizabeth, Chang, Priscilla, Lane, Steven W., Blinder, Russell, Galinsky, Ilene, Kesari, Santosh, Ho, Vincent T., Stone, Richard M. and Mullally, Ann (2010). CNS Relapse in Acute Promyeloctyic Leukemia. Journal of Clinical Oncology, 28 (24), E409-E411. doi: 10.1200/JCO.2009.27.1577

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

Kharas, Michael G., Lengner, Christopher J., Al-Shahrour, Fatima, Bullinger, Lars, Ball, Brian, Zaidi, Samir, Morgan, Kelly, Tam, Winnie, Paktinat, Mahnaz, Okabe, Rachel, Gozo, Maricel, Einhorn, William, Lane, Steven W., Scholl, Claudia, Froehling, Stefan, Fleming, Mark, Ebert, Benjamin L., Gilliland, D. Gary, Jaenisch, Rudolf and Daley, George Q. (2010). Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia. Nature Medicine, 16 (8), 903-908. doi: 10.1038/nm.2187

Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietis stem and progenitor cells

Mullally, Ann, Lane, Steven W., Ball, Brian, Megerdichian, Christine, Okabe, Rachel, Al-Shahrour, Fatima, Paktinat, Mahnaz, Haydu, J. Erika, Housman, Elizabeth, Lord, Allegra M., Wernig, Gerlinde, Kharas, Michael G., Mercher, Thomas, Kutok, Jeffery L., Gilliland, D. Gary and Ebert, Benjamin L. (2010). Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietis stem and progenitor cells. Cancer Cell, 17 (6), 584-596. doi: 10.1016/j.ccr.2010.05.015

The Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS

Lane, Steven W., Sykes, Stephen M., Al-Shahrour, Fatima, Shterental, Sebastian, Paktinat, Mahnaz, Lo Celso, Cristina, Jesneck, Jonathan L., Ebert, Benjamin L., Williams, David A. and Gilliland, D. Gary (2010). The Apcmin mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS. Blood, 115 (17), 3489-3497. doi: 10.1182/blood-2009-11-251728

Leukemia stem cells

Lane, Steven W. and Gilliland, D. Gary (2010). Leukemia stem cells. Seminars in Cancer Biology, 20 (2), 71-76. doi: 10.1016/j.semcancer.2009.12.001

Characterization of the bone marrow immunofluorescence test in childhood autoimmune neutropenia

Lane, S. W., Hassell, P., Kennedy, G. A., Fung, Y. L. and Williams, B. A. (2009). Characterization of the bone marrow immunofluorescence test in childhood autoimmune neutropenia. International Journal of Laboratory Hematology, 31 (5), 567-571. doi: 10.1111/j.1751-553X.2008.01084.x

The leukemic stem cell niche: Current concepts and therapeutic opportunities

Lane, Steven W., Scadden, David T. and Gilliland, D. Gary (2009). The leukemic stem cell niche: Current concepts and therapeutic opportunities. Blood, 114 (6), 1150-1157. doi: 10.1182/blood-2009-01-202606

Prolonged haematological toxicity from the hyper-CVAD regimen: Manifestations, frequency, and natural history in a cohort of 125 consecutive patients

Gill, Saar, Lane, Steven, Crawford, Julie, Cull, Gavin, Joske, David, Joske, David, Marlton, Paula, Mollee, Peter, Prince, Miles and Seymour, John (2008). Prolonged haematological toxicity from the hyper-CVAD regimen: Manifestations, frequency, and natural history in a cohort of 125 consecutive patients. Annals of Hematology, 87 (9), 727-734. doi: 10.1007/s00277-008-0488-6

A 1 log rise in RQ-PCR transcript levels defines molecular relapse in core binding factor accute myeloid leukemia and predicts subsequent morphologic relapse

Lane, Steven, Saal, Russell, Mollee, Peter, Jones, Mark, Grigg, Andrew, Taylor, Kerry, Seymour, John, Kennedy, Glen, Williams, Bronwyn, Grimmett, Karen, Griffiths, Vanessa, Gill, Devinder, Hourigan, Matthew and Marlton, Paula (2008). A 1 log rise in RQ-PCR transcript levels defines molecular relapse in core binding factor accute myeloid leukemia and predicts subsequent morphologic relapse. Leukemia & Lymphoma, 49 (3), 517-523. doi: 10.1080/10428190701817266

Palifermin-induced Acanthosis Nigricans

Lane, S. W., Manoharan, S. and Mollee, P. N. (2007). Palifermin-induced Acanthosis Nigricans. Internal Medicine Journal, 37 (6), 417-418. doi: 10.1111/j.1445-5994.2007.01340.x

Increased Mortality with FLA Compared with ADE Chemotherapy in High-risk AML (Letter to the Editor)

Lane, Steven W., Marlton, Paula and Mollee, Peter N. (2006). Increased Mortality with FLA Compared with ADE Chemotherapy in High-risk AML (Letter to the Editor). Blood, 108 (12), 3950-3951. doi: 10.1182/blood-2006-06-032680

Safety and efficacy of pegfilgrastim compared to granulocyte colony stimulating factor (G-CSF)supporting a dose-intensive, rapidly cycling anti-metabolite containing chemotherapy regimen (Hyper-CVAD) for lymphoid malignancy

Lane, Steven W., Crawford, Julie, Kenealy, Melita, Cull, Gavin, Seymour, John F., Prince, H. Miles, Marlton, Paula, Gill, Devinder ‌ and Mollee, Peter‌ N. (2006). Safety and efficacy of pegfilgrastim compared to granulocyte colony stimulating factor (G-CSF)supporting a dose-intensive, rapidly cycling anti-metabolite containing chemotherapy regimen (Hyper-CVAD) for lymphoid malignancy. Leukemia and Lymphoma, 47 (9), 1813-1817. doi: 10.1080/10428190600632832

Hereditary fibrinogen A alpha-chain amyloidosis

Lane, S. W., Goodman, H. J., Francis, L., Bofinger, A. M. and Mollee, P. N. (2006). Hereditary fibrinogen A alpha-chain amyloidosis. Pathology, 38 (4), 380-382. doi: 10.1080/00313020600820823

Role of VAD in the initial treatment of multiple myeloma

Lane, Steven W., Gill, Devinder, Mollee, Peter N. and Rajkumar, S. Vincent (2005). Role of VAD in the initial treatment of multiple myeloma. Blood, 106 (10), 3674-3675. doi: 10.1182/blood-2005-07-2610

Intestinal Pseudo-Obstruction Complicating Multiple Sclerosis

Lane, S. W. and Pender, M. P. (2005). Intestinal Pseudo-Obstruction Complicating Multiple Sclerosis. Internal Medicine Journal, 35 (3), 191-192. doi: 10.1111/j.1445-5994.2004.00753.x

Cytokine and Mutation Profiling Reveal Patterns of Complete Remission Rates with Lenzilumab Combination Therapy in Chronic Myelomonocytic Leukemia

Kutyna, Monika, Kamel, Maha M., Ross, David M., Yong, Agnes S. M., Fong, Chun Yew, Thompson-Peach, Chloe, Lane, Steven W., Yeung, David T., Hughes, Timothy P., Hiwase, Devendra and Thomas, Daniel (2023). Cytokine and Mutation Profiling Reveal Patterns of Complete Remission Rates with Lenzilumab Combination Therapy in Chronic Myelomonocytic Leukemia. 65th ASH Annual Meeting, San Diego, CA United States, 9-12 December 2023. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2023-179706

Early Generation Telomerase Deficient Mice to Investigate Clonal Hematopoiesis in Aging

Bruedigam, Claudia, Porter, Amy H., Straube, Jasmin, Cheng, Guidan, Heidel, Florian H. and Lane, Steven W. (2023). Early Generation Telomerase Deficient Mice to Investigate Clonal Hematopoiesis in Aging. 65th ASH Annual Meeting, San Diego, CA United States, 9-12 December 2023. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2023-191246

Excellent Early and Major Molecular Responses Observed with Asciminib Treatment for CP-CML: Results from the ALLG CML13 Ascend-CML Study

Yeung, David T., Shanmuganathan, Naranie, Reynolds, John, Branford, Susan, Walia, Mannu, Yong, Agnes S. M., Shortt, Jake, Burbury, Kate, Chee, Lynette C.Y., Viiala, Nick, Cunningham, Ilona, Ross, David M., D'Souza, Alwyn Bernard, Wright, Matthew P.F., Harrup, Rosemary Anne, Forsyth, Cecily, Filshie, Robin, Browett, Peter J., Lane, Steven W., Grove, Carolyn, Grigg, Andrew P., Hughes, Timothy P. and on Behalf Of The ALLG (2023). Excellent Early and Major Molecular Responses Observed with Asciminib Treatment for CP-CML: Results from the ALLG CML13 Ascend-CML Study. 65th ASH Annual Meeting, San Diego, CA United States, 9-12 December 2023. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2023-172583

Lenzilumab in Addition to Azacitidine Improves Complete Response Rates in Chronic Myelomonocytic Leukemia

Hiwase, Devendra, Ross, David M., Lane, Steven W., Thompson-Peach, Chloe, Fong, Chun Yew, Yong, Agnes S. M., Yeung, David T., Hughes, Timothy P. and Thomas, Daniel (2023). Lenzilumab in Addition to Azacitidine Improves Complete Response Rates in Chronic Myelomonocytic Leukemia. 65th ASH Annual Meeting, San Diego, CA United States, 9-12 December 2023. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2023-179688

Suppression of KRAS and CBL Mutations and Hematological Improvement By Lenzilumab and Azacitidine Treatment in Proliferative Chronic Myelomonocytic Leukemia

Kamel, Maha M., Kutyna, Monika, Ross, David M., Lane, Steven W., Thompson-Peach, Chloe, Fong, Chun Yew, Yong, Agnes S. M., Yeung, David T., Hughes, Timothy P., Hiwase, Devendra and Thomas, Daniel (2023). Suppression of KRAS and CBL Mutations and Hematological Improvement By Lenzilumab and Azacitidine Treatment in Proliferative Chronic Myelomonocytic Leukemia. 65th ASH Annual Meeting, San Diego, CA United States, 9-12 December 2023. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2023-188340

Trp53-Loss in Hematopoietic Stem Cells Drives the Evolutionary Process of Leukemic Transformation in a Jak2 V617F-Driven Myeloproliferative Neoplasms Mouse Model

Zhang, Ranran, Janardhanan, Yashaswini, Haldar, Rohit, Cooper, Leanne, Jaquelin, Sebastien, Straube, Jasmin, Bywater, Megan and Lane, Steven W. (2023). Trp53-Loss in Hematopoietic Stem Cells Drives the Evolutionary Process of Leukemic Transformation in a Jak2 V617F-Driven Myeloproliferative Neoplasms Mouse Model. 65th ASH Annual Meeting, San Diego, CA United States, 9-12 December 2023. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2023-188150

Immunoproteasome Function Maintains Oncogenic Gene Expression In Kmt2a-complex Driven Leukemia

Heidel, Florian, Tubio-Santamaria, Nuria, Jayavelu, Ashok Kumar, Schnoeder, Tina, Eifert, Theresa, Hsu, Chen-Jen, Perner, Florian, Zhang, Qirui, Wenge, Daniela, Hansen, Fynn, Jyotsana, Nidhi, Lane, Steven, von Eyss, Björn, Deshpande, Aniruddha, Kühn, Michael, Schwaller, Jürg, Ebstein, Frederic, Krüger, Elke, Hochhaus, Andreas, Heuser, Michael, Ori, alessandro, Mann, Matthias and Armstrong, Scott (2023). Immunoproteasome Function Maintains Oncogenic Gene Expression In Kmt2a-complex Driven Leukemia. 2023 Annual Scientific Meeting of the ISEH – International Society for Experimental Hematology, New York, NY United States, 17-20 August 2023. Philadelphia, PA United States: Elsevier. doi: 10.1016/j.exphem.2023.06.049

Early and Deep Molecular Responses Achieved with Frontline Asciminib in Chronic Phase CML - Interim Results from ALLG CML13 Ascend-CML

Yeung, David T., Shanmuganathan, Naranie, Reynolds, John, Branford, Susan, Walia, Mannu, Yong, Agnes S.M., Shortt, Jake, Burbury, Kate, Viiala, Nicholas, Cunningham, Ilona, Ross, David M., Harrup, Rosemary, Wright, Matthew, Forsyth, Cecily, D'Souza, Alwyn Bernard, Filshie, Robin J., Browett, Peter J., Lane, Steven W., Grove, Carolyn, Grigg, Andrew and Hughes, Timothy (2022). Early and Deep Molecular Responses Achieved with Frontline Asciminib in Chronic Phase CML - Interim Results from ALLG CML13 Ascend-CML. 64th ASH Annual Meeting, New Orleans, LA United States, 10-13 December 2022. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2022-157244

Imetelstat-Mediated Alterations in Lipid Metabolism to Induce Ferroptosis As Therapeutic Strategy for Acute Myeloid Leukemia

Bruedigam, Claudia, Porter, Amy H., Song, Axia, Vroeg in de Wei, Gerjanne, Stoll, Thomas, Straube, Jasmin, Cooper, Leanne T., Cheng, Guidan, Kahl, Vivian F.S., Sobinoff, Alexander, Ling, Victoria Y., Jebaraj, Billy Michael Chelliah, Bray, Laura J., Bullinger, Lars, Heidel, Florian H., Kennedy, Glen A., Hill, Michelle M., Pickett, Hilda, Abdel-Wahab, Omar, Hartel, Gunter and Lane, Steven W. (2022). Imetelstat-Mediated Alterations in Lipid Metabolism to Induce Ferroptosis As Therapeutic Strategy for Acute Myeloid Leukemia. 64th ASH Annual Meeting, New Orleans, LA United States, 10-13 December 2022. Washington, DC United States: American Society of Hematology. doi: 10.1182/blood-2022-168166

A Phase- Ib/II Clinical Evaluation of Ponatinib in Combination with Azacitidine in FLT₃-ITD and CBL-Mutant Acute Myeloid Leukemia (PON-AZA study)

Kipp, David, Loo, Sun, Perkins, Andrew Charles, Lane, Steven W., Blyth, Emily, Ejeti, Anoop Kumar, Bajel, Ashish, Reynolds, John and Wei, Andrew H. (2021). A Phase- Ib/II Clinical Evaluation of Ponatinib in Combination with Azacitidine in FLT3-ITD and CBL-Mutant Acute Myeloid Leukemia (PON-AZA study). 63rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Atlanta Ga, Dec 11-14, 2021. WASHINGTON: AMER SOC HEMATOLOGY. doi: 10.1182/blood-2021-154247

IL-28 Is a critical cytoprotectant in transplantation

Henden, A., Robb, R., Clouston, A., Kuns, R., Lane, S., Gartlan, K. and Hill, G. (2016). IL-28 Is a critical cytoprotectant in transplantation. International Congress of Immunology (ICI), Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley-VCH.

SSB1 AND SSB2 SINGLE-STRANDED DNA BINDING PROTEINS ARE ESSENTIAL FOR HSC FUNCTION

Vu, Therese, Shi, Wei, Lane, Steven and Khanna, Kum Kum (2015). SSB1 AND SSB2 SINGLE-STRANDED DNA BINDING PROTEINS ARE ESSENTIAL FOR HSC FUNCTION. 44th Annual Scientific Meeting of the International-Society-for-Experimental-Hematology (ISEH), Kyoto Japan, Sep 17-19, 2015. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.exphem.2015.06.274

The adaptor protein ASC controls transplantation outcomes independently of the inflammasome

Cheong, Melody, Gartlan, Kate, Tey, Siok-Keen, Kuns, Rachel, Lor, Mary, Lineburg, Katie, Tea, Bianca, Shi, Wei, Raju, Jyothy, Zhang, Ping, Varelias, Antiopi, Leveque-El Mouttie, Lucie, Olver, Stuart, Bunting, Mark, Lane, Steven, Boyle, Glen, Ting, Jenny, Schroder, Kate, Engwerda, Christian, Khanna, Kum Kum, Smyth, Mark, MacDonald, Kelli, Koyama, Motoko and Hill, Geoffrey (2015). The adaptor protein ASC controls transplantation outcomes independently of the inflammasome. Annual Meeting of the American-Association-of-Immunologists (IMMUNOLOGY), New Orleans La, May 08-12, 2015. BETHESDA: AMER ASSOC IMMUNOLOGISTS.

Investigation of mice deficient in matriptase-2, Hfe and transferrin receptor 2 reveals a novel non-hepatic role for Tfr2 in erythropoiesis

Wallace, D. F., Secondes, E. S., Rishi, G., Ostini, L., Mcdonald, C. J., Lane, S. W., Hooper, J. D., Lopez-Otin, C. and Subramaniam, V. N. (2014). Investigation of mice deficient in matriptase-2, Hfe and transferrin receptor 2 reveals a novel non-hepatic role for Tfr2 in erythropoiesis. Australian Gastroenterology Week 2014, Broadbeach, Australia, 22-24 October 2014. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12736_6

Akt/foxo signaling pathway enforces the differentiation blockade in myeloid leukemias

Sykes, S. M., Lane, S. W., Bullinger, L., Demetrios, K., Yusuf, R., Saez, B., Ferraro, F., Mercier, F., Singh, H., Brumme, K. M., Acharya, S., Scholl, C., Tothova, Z., Attar, E., Froehling, S., DePinho, R. A., Gilliland, D. G., Armstrong, S. A. and Sca, D. T. (2011). Akt/foxo signaling pathway enforces the differentiation blockade in myeloid leukemias. ISEH 40th Annual Scientific Meeting, -, 25 - 28 August 2011. Philadelphia, PA, United States: Elsevier.

Evaluating clonal dominance in a murine knock-in model of Jak2V617F MPN

Mullally, Ann, Poveromo, Luke, Brumme, Kristina, Al-Shahrour, Fatima, Lane, Steven W., Shih, Alan H., Aifantis, Iannis, Levine, Ross L. and Ebert, Benjamin L. (2011). Evaluating clonal dominance in a murine knock-in model of Jak2V617F MPN. 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, San Diego, CA, United States, 10-13 Dec 2011. Washington, DC, United States: American Society of Hematology.

Mtor complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis

Kalaitzidis, Demetrios, Sykes, Stephen M., Punt, Natalie, Tang, Yuefeng, Lane, Steven W., Clish, Clary, Gilliland, D. Gary, Scadden, David T., Guertin, David and Armstrong, Scott A. (2011). Mtor complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, San Diego, CA, United States, 10-13 Dec 2011. Washington, DC, United States: American Society of Hematology.

Myeloid leukemogenesis driven by aberrant CDX2 expression involves transcriptional repression of KLF4 and deregulated PPAR gamma signaling

Faber, Katrin, Bullinger, Lars, Garding, Angela, Mertens, Daniel, Martin, Daniela, Walcher, Daniel, Doehner, Konstanze, Doehner, Hartmut, Sykes, Stephen M., Claus, Rainer, Plass, Christoph, Lane, Steven W., Scholl, Claudia and Froehling, Stefan (2011). Myeloid leukemogenesis driven by aberrant CDX2 expression involves transcriptional repression of KLF4 and deregulated PPAR gamma signaling. 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, San Diego, CA, United States, 10-13 Dec 2011. Washington, DC, United States: American Society of Hematology.

Pak A proteins are essential for hematopoietic stem/progenitor cell (HSC/P) engraftment through regulation of signaling pathways controlling HSC/P proliferation, survival, migration, and the actin cytoskeleton

Dorrance, Adrienne M., Kosoff', Rachelle, McGuinness, Meaghan, Harris, Chad, De Vita, Serena, Mathieu, Ronald, Lane, Steven W., Milsom, Michael D., Chernoff, Jonathan and Williams, David A. (2011). Pak A proteins are essential for hematopoietic stem/progenitor cell (HSC/P) engraftment through regulation of signaling pathways controlling HSC/P proliferation, survival, migration, and the actin cytoskeleton. 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, San Diego, CA, United States, 10-13 Dec 2011. Washington, DC, United States: American Society of Hematology.

Characterizing the disease-initiating cell population in a murine model of Jak2V617F+ myeloproliferative neoplasm

Mullally, Ann, Lane, Steven W., Poveromo, Luke, Al-Shahrour, Fatima, Kutok, Jeffery and Ebert, Benjamin L. (2010). Characterizing the disease-initiating cell population in a murine model of Jak2V617F+ myeloproliferative neoplasm. 52nd Annual Meeting of the American Society of Hematology (ASH), Orlando, FL, United States, 4-7 Dec 2010. Washington, DC, United States: American Society of Hematology.

Leukemia stem cells occupy niches that are physically distinct and independent of the normal constraints that apply to hematopoietic stem cells

Lane, S. W., Sykes, S. M., Ferraro, F., Lin, C. P., Gilliland, D. G., Williams, D. A., Scadden, D. T. and Lo Celso, C. (2010). Leukemia stem cells occupy niches that are physically distinct and independent of the normal constraints that apply to hematopoietic stem cells. 39th Annual Scientific Meeting of the ISEH Society for Hematology and Stem Cells, Melbourne Australia, 15-18 September 2010. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.exphem.2010.07.008

Leukemia stem cells are resistant to in vivo, cell non-autonomous Wnt inhibition.

Lane, Steven W., Lo Celso, Cristina, Sykes, Stephen M., Shterental, Sebastian, Paktinat, Mahnaz, Lin, Charles P., Williams, David A., Scadden, David T. and Gilliland, D. Gary (2009). Leukemia stem cells are resistant to in vivo, cell non-autonomous Wnt inhibition.. 51st Annual Meeting of the American Society of Hematology, New Orleans, LA, United States, 5-8 Dec 2009. Washington, DC, United States: American Society of Hematology.

WT1 Expression Levels at Diagnosis and as a Marker of Minimal Residual Disease (MRD) in Patients with Acute Myeloid Leukaernia (AML)

Gray, J. X., McMillen, L., Saal, R., Lane, S., Mollee, P., Bird, R., Gill, D. and Marlton, P. (2009). WT1 Expression Levels at Diagnosis and as a Marker of Minimal Residual Disease (MRD) in Patients with Acute Myeloid Leukaernia (AML). 51st Annual Meeting of the American Society of Hematology, New Orleans, LA, United States, 5-8 December 2009. Washington, DC, United States: American Society of Hematology.

Characterisation and prognostic significance of WT-1 gene expression in acute myeloid leukemia (AML).

Lane, SW, Saal, R, Negus, S, Mollee, P, Mather, M, Gill, D, Mills, AK, Bird, RJ, Hourigan, MJ, Jones, M and Marlton, P (2006). Characterisation and prognostic significance of WT-1 gene expression in acute myeloid leukemia (AML).. 48th Annual Meeting of the American-Society-of-Hematology, Orlando Fl, Dec 09-12, 2006. WASHINGTON: AMER SOC HEMATOLOGY.

Prolonged hematologic toxicity from the Hyper-CVAD regimen; manifestations, frequency, and natural history in a cohort of 125 consecutive patients

Gill, S., Lane, S., Crawford, J., Mollee, P., Marlton, P., Cull, G., Prince, M. and Seymour, J. F. (2006). Prolonged hematologic toxicity from the Hyper-CVAD regimen; manifestations, frequency, and natural history in a cohort of 125 consecutive patients. 48th Annual Meeting of the American-Society-of-Hematology, Orlando, FL, United States, 9-12 December 2006. Washington, DC, United States: American Society of Hematology.

Real-time quantitative polymerase chain reaction (RQ-PCR) monitoring of minimal residual disease (MRD) in core binding factor acute myeloid leukaemia (CBF AML).

Lane, SW, Saal, R, Mollee, P, Grigg, A, Taylor, K, Seymour, JF, Kennedy, G, Williams, B, Jones, M, Grimmett, K, Griffiths, V, Gill, D, Hourigan, M and Marlton, P (2006). Real-time quantitative polymerase chain reaction (RQ-PCR) monitoring of minimal residual disease (MRD) in core binding factor acute myeloid leukaemia (CBF AML).. 48th Annual Meeting of the American-Society-of-Hematology, Orlando, FL, United States, 9-12 December 2006. Washington, DC, United States: American Society of Hematology.

Aggressive cutaneous squamous cell carcinoma (SCC) in chronic lymphocytic leukaemia (CLL)

Lane, S. W., Mollee, P. N., Bird, R., Porceddu, S. and Gill, D. (2005). Aggressive cutaneous squamous cell carcinoma (SCC) in chronic lymphocytic leukaemia (CLL). 47th Annual Meeting of the American Society of Hematology, Atlanta, GA, United States, 10-13 December 2005. Washington, DC, United States: American Society of Hematology.

Pegfilgrastim compared to granulocyte colony stimulating factor (G-CSF) with hyper-CVAD chemotherapy regimen for aggressive lymphoid malignancy.

Lane, SW, Crawford, J, Kenealy, M, Cull, G, Seymour, JF, Prince, M, Marlton, P, Gill, D and Mollee, PN (2005). Pegfilgrastim compared to granulocyte colony stimulating factor (G-CSF) with hyper-CVAD chemotherapy regimen for aggressive lymphoid malignancy.. 47th Annual Meeting of the American-Society-of-Hematology, Atlanta Ga, Dec 10-13, 2005. WASHINGTON: AMER SOC HEMATOLOGY.

Orthodontic Surgery, An Adjunct to Cleft-Palate Treatment

Lane, SW, Hoffman, S and Gibbs, SL (1977). Orthodontic Surgery, An Adjunct to Cleft-Palate Treatment.