The University of Queensland

Scalable Quasi-Divided Cell Operation Using Spinning Cylinder Electrode Technology: Multigram Electrochemical Synthesis of an Axitinib Intermediate

Malviya, Bhanwar K., Hansen, Eric C., Kong, Caleb J., Imbrogno, Joseph, Verghese, Jenson, Guinness, Steven M., Salazar, Chase A., Desrosiers, Jean-Nicolas, Kappe, C. Oliver and Cantillo, David (2024). Scalable Quasi-Divided Cell Operation Using Spinning Cylinder Electrode Technology: Multigram Electrochemical Synthesis of an Axitinib Intermediate. Organic Process Research & Development, 28 (3), 790-797. doi: 10.1021/acs.oprd.3c00508

Aniline derivatives from lignin under mild conditions enabled by electrochemistry

Castillo-Garcia, Antonio A., Kappe, Christian Oliver, Cantillo, David and Barta, Katalin (2024). Aniline derivatives from lignin under mild conditions enabled by electrochemistry. ChemSusChem, 17 (3) e202301374. doi: 10.1002/cssc.202301374

Recent advances in synthetic organic electrochemistry using flow systems

Cantillo, David (2024). Recent advances in synthetic organic electrochemistry using flow systems. Current Opinion in Electrochemistry 101459, 101459. doi: 10.1016/j.coelec.2024.101459

Development of an open-source flow-through cyclic voltammetry cell for real-time inline reaction analytics

Rial-Rodríguez, Eduardo, Williams, Jason D., Eggenweiler, Hans-Michael, Fuchss, Thomas, Sommer, Alena, Kappe, C. Oliver and Cantillo, David (2024). Development of an open-source flow-through cyclic voltammetry cell for real-time inline reaction analytics. Reaction Chemistry and Engineering, 9 (1), 26-30. doi: 10.1039/d3re00535f

Electrifying Friedel-Crafts intramolecular alkylation toward 1,1-disubstituted tetrahydronaphthalenes

Lunghi, Enrico, Ronco, Pietro, Della Negra, Federico, Trucchi, Beatrice, Verzini, Massimo, Merli, Daniele, Casali, Emanuele, Kappe, C Oliver, Cantillo, David and Zanoni, Giuseppe (2023). Electrifying Friedel-Crafts intramolecular alkylation toward 1,1-disubstituted tetrahydronaphthalenes. The Journal of Organic Chemistry, 88 (24), 16783-16789. doi: 10.1021/acs.joc.3c01281

A Low-Volume Flow Electrochemical Microreactor for Rapid and Automated Process Optimization

Rial-Rodríguez, Eduardo, Wagner, Johannes F., Eggenweiler, Hans-Michael, Fuchss, Thomas, Sommer, Alena, Kappe, C. Oliver, Williams, Jason and Cantillo, David (2023). A Low-Volume Flow Electrochemical Microreactor for Rapid and Automated Process Optimization. Reaction Chemistry & Engineering, 9 (1), 1-6. doi: 10.1039/d3re00586k

Multigram electrochemical Hofmann rearrangement using a spinning three-dimensional anode

Malviya, Bhanwar K., Bottecchia, Cecilia, Stone, Kevin, Lehnherr, Dan, Lévesque, François, Kappe, C. Oliver and Cantillo, David (2023). Multigram electrochemical Hofmann rearrangement using a spinning three-dimensional anode. Organic Process Research and Development, 27 (11), 2183-2191. doi: 10.1021/acs.oprd.3c00332

Metal‐free electrochemical reduction of disulfides in an undivided cell under mass transfer control

Malviya, Bhanwar K., Hansen, Eric C., Kong, Caleb J., Imbrogno, Joseph, Verghese, Jenson, Guinness, Steven M., Salazar, Chase A., Desrosiers, Jean‐Nicolas, Kappe, C. Oliver and Cantillo, David (2023). Metal‐free electrochemical reduction of disulfides in an undivided cell under mass transfer control. Chemistry: A European Journal, 29 (66) e202302664, 1-7. doi: 10.1002/chem.202302664

Scaling-up Electroorganic Synthesis Using a Spinning Electrode Electrochemical Reactor in Batch and Flow Mode

Petrović, Nikola, Malviya, Bhanwar K., Kappe, C. Oliver and Cantillo, David (2023). Scaling-up Electroorganic Synthesis Using a Spinning Electrode Electrochemical Reactor in Batch and Flow Mode. Organic Process Research & Development, 27 (11), 2072-2081. doi: 10.1021/acs.oprd.3c00255

Electrochemical nickel-catalyzed C(sp3)–C(sp3) cross-coupling of alkyl halides with alkyl tosylates

Ibrahim, Malek Y. S., Cumming, Graham R., Gonzalez de Vega, Raquel, Garcia-Losada, Pablo, de Frutos, Oscar, Kappe, C. Oliver and Cantillo, David (2023). Electrochemical nickel-catalyzed C(sp3)–C(sp3) cross-coupling of alkyl halides with alkyl tosylates. Journal of the American Chemical Society, 145 (31), 17023-17028. doi: 10.1021/jacs.3c07313

Control of a complex multistep process for the production of mesalazine

Castillo, Ismael, Rehrl, Jakob, Sagmeister, Peter, Lebl, Rene, Kruisz, Julia, Celikovic, Selma, Sipek, Martin, Kirschneck, Dirk, Horn, Martin, Sacher, Stephan, Cantillo, David, Williams, Jason D., Khinast, Johannes G. and Kappe, Oliver (2023). Control of a complex multistep process for the production of mesalazine. Journal of Process Control, 122, 59-68. doi: 10.1016/j.jprocont.2022.12.009

Panel discussion on... FLOW CHEMISTRY

Cantillo, David, Monedero, Martin, Dapremont, Olivier, Lusso, Carlo, McLaws, Mark, Blocher, Thomas, Wiles, Charlotte, Houldsworth, Stephen, Vizza, Alessandra, Hornung, Christian H., Kaaden, Anne, Stam, Wouter, McKay, Chris, Katz, Marianna, Borukhova, Svetlana, Kirschneck, Dirk, Ni, Xiong-Wei, Guillermin, Jean-Baptiste, Rouchet, Jean-Baptiste, Yazdanpanah, Nima, Roletto, Jacopo, Jenkins, Gareth, Poechlauer, Peter, Nuño, Manuel and Adamo, Andrea (2022). Panel discussion on... FLOW CHEMISTRY. Chimica Oggi, 40 (4), 16-41.

Sustainable synthesis of noroxymorphone via a key electrochemical N-demethylation step

Sommer, Florian, Gerber Aeschbacher, Roman, Thurnheer, Urs, Kappe, C. Oliver and Cantillo, David (2022). Sustainable synthesis of noroxymorphone via a key electrochemical N-demethylation step. ACS Sustainable Chemistry and Engineering, 10 (27), 8988-8996. doi: 10.1021/acssuschemeng.2c02824

Electrochemical oxidation of alcohols using nickel oxide hydroxide as heterogeneous electrocatalyst in batch and continuous flow

Jud, Wolfgang, Salazar, Chase A., Imbrogno, Joseph, Verghese, Jenson, Guinness, Steven M., Desrosiers, Jean-Nicolas, Kappe, C. Oliver and Cantillo, David (2022). Electrochemical oxidation of alcohols using nickel oxide hydroxide as heterogeneous electrocatalyst in batch and continuous flow. Organic Process Research and Development, 26 (5), 1486-1495. doi: 10.1021/acs.oprd.2c00064

Scalable continuous flow hydrogenations using Pd/Al₂O₃-coated rectangular cross-section 3D-printed static mixers

Lebl, Rene, Zhu, Yutong, Ng, Derrick, Hornung, Christian H., Cantillo, David and Kappe, C. Oliver (2022). Scalable continuous flow hydrogenations using Pd/Al2O3-coated rectangular cross-section 3D-printed static mixers. Catalysis Today, 383, 55-63. doi: 10.1016/j.cattod.2020.07.046

Synthesis of active pharmaceutical ingredients using electrochemical methods: keys to improve sustainability

Cantillo, David (2022). Synthesis of active pharmaceutical ingredients using electrochemical methods: keys to improve sustainability. Chemical Communications, 58 (5), 619-628. doi: 10.1039/d1cc06296d

Continuous flow synthesis of a blocked polyisocyanate: process intensification, reaction monitoring via in-line FTIR analysis, and comparative life cycle assessment

Glotz, Gabriel, Waniek, Katharina, Schöggl, Josef-Peter, Cantillo, David, Stueckler, Clemens, Arzt, Anton, Gollner, Andreas, Schipfer, Rudolf, Baumgartner, Rupert J. and Kappe, C. Oliver (2021). Continuous flow synthesis of a blocked polyisocyanate: process intensification, reaction monitoring via in-line FTIR analysis, and comparative life cycle assessment. Organic Process Research and Development, 25 (10), 2367-2379. doi: 10.1021/acs.oprd.1c00329

A small footprint oxycodone generator based on continuous flow technology and real-time analytics

Sommer, Florian, Cantillo, David and Kappe, C. Oliver (2021). A small footprint oxycodone generator based on continuous flow technology and real-time analytics. Journal of Flow Chemistry, 11 (4), 707-715. doi: 10.1007/s41981-021-00193-y

Electrochemical α-arylation of ketones via anodic oxidation of in situ generated silyl enol ethers

Jud, Wolfgang, Sommer, Florian, Kappe, C. Oliver and Cantillo, David (2021). Electrochemical α-arylation of ketones via anodic oxidation of in situ generated silyl enol ethers. The Journal of Organic Chemistry, 86 (22), 16026-16034. doi: 10.1021/acs.joc.1c01224

One-pot multistep electrochemical strategy for the modular synthesis of epoxides, glycols, and aldehydes from alkenes

Jud, Wolfgang, Kappe, C. Oliver and Cantillo, David (2021). One-pot multistep electrochemical strategy for the modular synthesis of epoxides, glycols, and aldehydes from alkenes. Electrochemical Science Advances, 1 (3) e2100002, 1-9. doi: 10.1002/elsa.202100002

Chemoselective electrochemical oxidation of secondary alcohols using a recyclable chloride-based mediator

Cantillo, David, Sommer, Florian and Kappe, C. Oliver (2021). Chemoselective electrochemical oxidation of secondary alcohols using a recyclable chloride-based mediator. Synlett, 33 (02), 166-170. doi: 10.1055/a-1511-8869

Advanced real-time process analytics for multistep synthesis in continuous flow

Sagmeister, Peter, Lebl, Rene, Castillo, Ismael, Rehrl, Jakob, Kruisz, Julia, Sipek, Martin, Horn, Martin, Sacher, Stephan, Cantillo, David, Williams, Jason D. and Kappe, C. Oliver (2021). Advanced real-time process analytics for multistep synthesis in continuous flow. Angewandte Chemie-International Edition, 60 (15), 8139-8148. doi: 10.1002/anie.202016007

Flow technology for telescoped generation, lithiation and electrophilic (C3) functionalization of highly strained 1-azabicyclo[1.1.0]butanes

Musci, Pantaleo, von Keutz, Timo, Belaj, Ferdinand, Degennaro, Leonardo, Cantillo, David, Kappe, C. Oliver and Luisi, Renzo (2021). Flow technology for telescoped generation, lithiation and electrophilic (C3) functionalization of highly strained 1-azabicyclo[1.1.0]butanes. Angewandte Chemie-International Edition, 60 (12), 6395-6399. doi: 10.1002/anie.202014881

Electrochemically enabled one‐pot multistep synthesis of C19 androgen steroids

Sommer, Florian, Kappe, C. Oliver and Cantillo, David (2021). Electrochemically enabled one‐pot multistep synthesis of C19 androgen steroids. Chemistry: A European Journal, 27 (19), 6044-6049. doi: 10.1002/chem.202100446

Sustainable electrochemical decarboxylative acetoxylation of aminoacids in batch and continuous flow

Köckinger, Manuel, Hanselmann, Paul, Roberge, Dominique M., Geotti-Bianchini, Piero, Kappe, C. Oliver and Cantillo, David (2021). Sustainable electrochemical decarboxylative acetoxylation of aminoacids in batch and continuous flow. Green Chemistry, 23 (6), 2382-2390. doi: 10.1039/d1gc00201e

A continuous flow bromodimethylsulfonium bromide generator: application to the synthesis of 2-arylaziridines from styrenes

Prieschl, Michael, Cantillo, David and Kappe, C. Oliver (2020). A continuous flow bromodimethylsulfonium bromide generator: application to the synthesis of 2-arylaziridines from styrenes. Journal of Flow Chemistry, 11 (2), 117-125. doi: 10.1007/s41981-020-00125-2

Continuous on demand generation of acrolein from glycerol using a reactive distillation strategy

Strauss, Franz J., Pöchlauer, Peter, Schuster, Christian, Kohls, Paul, Steinhofer, Stefan, Zinganell, Christopher, Gutmann, Bernhard, Cantillo, David and Kappe, C. Oliver (2020). Continuous on demand generation of acrolein from glycerol using a reactive distillation strategy. Chimica Oggi/Chemistry Today, 38 (6), 24-27.

Development and assembly of a flow cell for single‐pass continuous electroorganic synthesis using laser‐cut components

Jud, Wolfgang, Kappe, C. Oliver and Cantillo, David (2020). Development and assembly of a flow cell for single‐pass continuous electroorganic synthesis using laser‐cut components. Chemistry–Methods, 1 (1), 36-41. doi: 10.1002/cmtd.202000042

Organomagnesium based flash chemistry: continuous flow generation and utilization of halomethylmagnesium intermediates

von Keutz, Timo, Cantillo, David and Kappe, C. Oliver (2020). Organomagnesium based flash chemistry: continuous flow generation and utilization of halomethylmagnesium intermediates. Organic Letters, 22 (19), 7537-7541. doi: 10.1021/acs.orglett.0c02725

Electrochemical N-demethylation of 14-hydroxy morphinans: sustainable access to opioid antagonists

Glotz, Gabriel, Kappe, C. Oliver and Cantillo, David (2020). Electrochemical N-demethylation of 14-hydroxy morphinans: sustainable access to opioid antagonists. Organic Letters, 22 (17), 6891-6896. doi: 10.1021/acs.orglett.0c02424

A continuous flow cell for high‐temperature/high‐pressure electroorganic synthesis

Jud, Wolfgang, Kappe, C. Oliver and Cantillo, David (2020). A continuous flow cell for high‐temperature/high‐pressure electroorganic synthesis. ChemElectroChem, 7 (13), 2777-2783. doi: 10.1002/celc.202000696

Organophotocatalytic N‐demethylation of oxycodone using molecular oxygen

Chen, Yuesu, Glotz, Gabriel, Cantillo, David and Kappe, C. Oliver (2020). Organophotocatalytic N‐demethylation of oxycodone using molecular oxygen. Chemistry: A European Journal, 26 (13), 2973-2979. doi: 10.1002/chem.201905505

Translating batch electrochemistry to single-pass continuous flow conditions: an organic chemist’s guide

Maljuric, Snjezana, Jud, Wolfgang, Kappe, C. Oliver and Cantillo, David (2020). Translating batch electrochemistry to single-pass continuous flow conditions: an organic chemist’s guide. Journal of Flow Chemistry, 10 (1), 181-190. doi: 10.1007/s41981-019-00050-z

Continuous flow synthesis of terminal epoxides from ketones using in situ generated bromomethyl lithium

von Keutz, Timo, Cantillo, David and Kappe, C. Oliver (2019). Continuous flow synthesis of terminal epoxides from ketones using in situ generated bromomethyl lithium. Organic Letters, 21 (24), 10094-10098. doi: 10.1021/acs.orglett.9b04072

Continuous flow synthesis of methyl oximino acetoacetate: accessing greener purification methods with inline liquid–liquid extraction and membrane separation technology

Lebl, René, Murray, Trevor, Adamo, Andrea, Cantillo, David and Kappe, C. Oliver (2019). Continuous flow synthesis of methyl oximino acetoacetate: accessing greener purification methods with inline liquid–liquid extraction and membrane separation technology. ACS Sustainable Chemistry and Engineering, 7 (24), 20088-20096. doi: 10.1021/acssuschemeng.9b05954

Cathodic C–H trifluoromethylation of arenes and heteroarenes enabled by an in situ-generated triflyltriethylammonium complex

Jud, Wolfgang, Maljuric, Snjezana, Kappe, C. Oliver and Cantillo, David (2019). Cathodic C–H trifluoromethylation of arenes and heteroarenes enabled by an in situ-generated triflyltriethylammonium complex. Organic Letters, 21 (19), 7970-7975. doi: 10.1021/acs.orglett.9b02948

Continuous generation, in-line quantification and utilization of nitrosyl chloride in photonitrosation reactions

Lebl, Rene, Cantillo, David and Kappe, C. Oliver (2019). Continuous generation, in-line quantification and utilization of nitrosyl chloride in photonitrosation reactions. Reaction Chemistry and Engineering, 4 (4), 738-746. doi: 10.1039/c8re00323h

Visible light‐promoted Beckmann rearrangements: separating sequential photochemical and thermal phenomena in a continuous flow reactor

Chen, Yuesu, Cantillo, David and Kappe, C. Oliver (2019). Visible light‐promoted Beckmann rearrangements: separating sequential photochemical and thermal phenomena in a continuous flow reactor. European Journal of Organic Chemistry, 2019 (11), 2163-2171. doi: 10.1002/ejoc.201900231

Enhanced mixing of biphasic liquid-liquid systems for the synthesis of gem-dihalocyclopropanes using packed bed reactors

von Keutz, Timo, Cantillo, David and Kappe, C. Oliver (2019). Enhanced mixing of biphasic liquid-liquid systems for the synthesis of gem-dihalocyclopropanes using packed bed reactors. Journal of Flow Chemistry, 9 (1), 27-34. doi: 10.1007/s41981-018-0026-1

Continuous-flow protocol for the synthesis of enantiomerically pure intermediates of anti epilepsy and anti tuberculosis active pharmaceutical ingredients

Aguiar, Renata M., Leão, Raquel A. C., Mata, Alejandro, Cantillo, David, Kappe, C. Oliver, Miranda, Leandro S. M. and de Souza, Rodrigo O. M. A. (2019). Continuous-flow protocol for the synthesis of enantiomerically pure intermediates of anti epilepsy and anti tuberculosis active pharmaceutical ingredients. Organic and Biomolecular Chemistry, 17 (6), 1552-1557. doi: 10.1039/c8ob03088j

On the reactivity of anodically generated trifluoromethyl radicals toward aryl alkynes in organic/aqueous media

Jud, Wolfgang, Kappe, C. Oliver and Cantillo, David (2019). On the reactivity of anodically generated trifluoromethyl radicals toward aryl alkynes in organic/aqueous media. Organic and Biomolecular Chemistry, 17 (14), 3529-3537. doi: 10.1039/c9ob00456d

Catalyst‐free oxytrifluoromethylation of alkenes through paired electrolysis in organic‐aqueous media

Jud, Wolfgang, Kappe, C. Oliver and Cantillo, David (2018). Catalyst‐free oxytrifluoromethylation of alkenes through paired electrolysis in organic‐aqueous media. Chemistry: A European Journal, 24 (65), 17234-17238. doi: 10.1002/chem.201804708

Continuous flow photochemical benzylic bromination of a key intermediate in the synthesis of a 2-oxazolidinone

Chen, Yuesu, de Frutos, Oscar, Mateos, Carlos, Rincon, Juan A., Cantillo, David and Kappe, C. Oliver (2018). Continuous flow photochemical benzylic bromination of a key intermediate in the synthesis of a 2-oxazolidinone. Chemphotochem, 2 (10), 906-912. doi: 10.1002/cptc.201800114

Continuous flow multistep synthesis of α-functionalized esters via lithium enolate intermediates

von Keutz, Timo, Strauss, Franz J., Cantillo, David and Kappe, C. Oliver (2018). Continuous flow multistep synthesis of α-functionalized esters via lithium enolate intermediates. Tetrahedron, 74 (25), 3113-3117. doi: 10.1016/j.tet.2017.11.063

Review of Timothy Noël (ed): photochemical processes in continuous flow reactors: from engineering principles to chemical applications

Cantillo, David (2018). Review of Timothy Noël (ed): photochemical processes in continuous flow reactors: from engineering principles to chemical applications. Journal of Flow Chemistry, 8 (2), 107-108. doi: 10.1007/s41981-018-0011-8

Process intensification and integration studies for the generation of a key aminoimidazole intermediate in the synthesis of lanabecestat

Znidar, Desiree, Cantillo, David, Inglesby, Phillip, Boyd, Alistair and Kappe, C. Oliver (2018). Process intensification and integration studies for the generation of a key aminoimidazole intermediate in the synthesis of lanabecestat. Organic Process Research and Development, 22 (5), 633-640. doi: 10.1021/acs.oprd.8b00089

Continuous multistep synthesis of 2-(azidomethyl)oxazoles

Rossa, Thais A., Suveges, Nicolas S., Sa, Marcus M., Cantillo, David and Kappe, C. Oliver (2018). Continuous multistep synthesis of 2-(azidomethyl)oxazoles. Beilstein Journal of Organic Chemistry, 14, 506-514. doi: 10.3762/bjoc.14.36

An integrated continuous-flow synthesis of a key oxazolidine intermediate to noroxymorphone from naturally occurring opioids

Mata, Alejandro, Cantillo, David and Kappe, C. Oliver (2017). An integrated continuous-flow synthesis of a key oxazolidine intermediate to noroxymorphone from naturally occurring opioids. European Journal of Organic Chemistry, 2017 (44), 6505-6510. doi: 10.1002/ejoc.201700811

Hydrogen sulfide chemistry in continuous flow: Efficient synthesis of 2-oxopropanethioamide

Cantillo, David, Inglesby, Phillip A., Boyd, Alistair and Kappe, C. Oliver (2017). Hydrogen sulfide chemistry in continuous flow: Efficient synthesis of 2-oxopropanethioamide. Journal of Flow Chemistry, 7 (2), 29-32. doi: 10.1556/1846.2017.00006

Halogenation of organic compounds using continuous flow and microreactor technology

Cantillo, David and Kappe, C. Oliver (2017). Halogenation of organic compounds using continuous flow and microreactor technology. Reaction Chemistry and Engineering, 2 (1), 7-19. doi: 10.1039/c6re00186f

Design and development of Pd-catalyzed aerobic N-demethylation strategies for the synthesis of noroxymorphone in continuous flow mode

Gutmann, Bernhard, Cantillo, David, Weigl, Ulrich, Cox, D. Phillip and Kappe, C. Oliver (2017). Design and development of Pd-catalyzed aerobic N-demethylation strategies for the synthesis of noroxymorphone in continuous flow mode. European Journal of Organic Chemistry, 2017 (4), 914-927. doi: 10.1002/ejoc.201601453

Continuous flow synthesis of a key 1,4-benzoxazinone intermediate via a nitration/hydrogenation/cyclization sequence

Cantillo, David, Wolf, Bernd, Goetz, Roland and Kappe, C. Oliver (2017). Continuous flow synthesis of a key 1,4-benzoxazinone intermediate via a nitration/hydrogenation/cyclization sequence. Organic Process Research and Development, 21 (1), 125-132. doi: 10.1021/acs.oprd.6b00409

Visible-light photoredox catalysis using a macromolecular ruthenium complex: reactivity and recovery by size-exclusion nanofiltration in continuous flow

Guerra, Javier, Cantillo, David and Kappe, C. Oliver (2016). Visible-light photoredox catalysis using a macromolecular ruthenium complex: reactivity and recovery by size-exclusion nanofiltration in continuous flow. Catalysis Science and Technology, 6 (13), 4695-4699. doi: 10.1039/c6cy00070c

Diazo strategy for the synthesis of pyridazines: pivotal impact of the configuration of the diazo precursor on the process

Nikolaev, Valerij A., Cantillo, David, Kappe, C. Oliver, Medvedev, Jury J., Prakash, G. K. Surya and Supurgibekov, Murat B. (2016). Diazo strategy for the synthesis of pyridazines: pivotal impact of the configuration of the diazo precursor on the process. Chemistry: A European Journal, 22 (1), 174-184. doi: 10.1002/chem.201503448

A laboratory-scale continuous flow chlorine generator for organic synthesis

Strauss, Franz J., Cantillo, David, Guerra, Javier and Kappe, C. Oliver (2016). A laboratory-scale continuous flow chlorine generator for organic synthesis. Reaction Chemistry and Engineering, 1 (5), 472-476. doi: 10.1039/c6re00135a

Safe generation and use of bromine azide under continuous flow conditions - selective 1,2-bromoazidation of olefins

Cantillo, David, Gutmann, Bernhard and Kappe, C. Oliver (2016). Safe generation and use of bromine azide under continuous flow conditions - selective 1,2-bromoazidation of olefins. Organic and Biomolecular Chemistry, 14 (3), 853-857. doi: 10.1039/c5ob02425k

A pioneering early microreactor concept for ultrafast nitration reactions — Placing the seminal Brennecke and Kobe 1956 contribution into perspective

David Cantillo (2015). A pioneering early microreactor concept for ultrafast nitration reactions — Placing the seminal Brennecke and Kobe 1956 contribution into perspective. Journal of Flow Chemistry, 5 (4), 195-196. doi: 10.1556/1846.2015.00021

Light-induced C-H arylation of (hetero)arenes by in situ generated diazo anhydrides

Cantillo, David, Mateos, Carlos, Rincon, Juan A., de Frutos, Oscar and Oliver Kappe, C. (2015). Light-induced C-H arylation of (hetero)arenes by in situ generated diazo anhydrides. Chemistry: A European Journal, 21 (37), 12894-12898. doi: 10.1002/chem.201502357

Homogeneous vs immobilized palladium catalysts for continuous flow cross-coupling chemistry

Cantillo, David and Kappe, C. Oliver (2015). Homogeneous vs immobilized palladium catalysts for continuous flow cross-coupling chemistry. Chimica Oggi, 33 (4), 6-10.

Continuous-flow technology - A tool for the safe manufacturing of active pharmaceutical ingredients

Gutmann, Bernhard, Cantillo, David and Kappe, C. Oliver (2015). Continuous-flow technology - A tool for the safe manufacturing of active pharmaceutical ingredients. Angewandte Chemie (International Edition), 54 (23), 6688-6728. doi: 10.1002/anie.201409318

Covalent adduct formation between the plasmalogen-derived modification product 2-chlorohexadecanal and phloretin

Ullen, Andreas, Nusshold, Christoph, Glasnov, Toma, Saf, Robert, Cantillo, David, Eibinger, Gerald, Reicher, Helga, Fauler, Guenter, Bernhart, Eva, Hallstrom, Seth, Kogelnik, Nora, Zangger, Klaus, Kappe, C. Oliver, Malle, Ernst and Sattler, Wolfgang (2015). Covalent adduct formation between the plasmalogen-derived modification product 2-chlorohexadecanal and phloretin. Biochemical Pharmacology, 93 (4), 470-481. doi: 10.1016/j.bcp.2014.12.017

Benchmarking immobilized Di- and triarylphosphine palladium catalysts for continuous-flow cross-coupling reactions: efficiency, durability, and metal leaching studies

Greco, Roberto, Goessler, Walter, Cantillo, David and Kappe, C. Oliver (2015). Benchmarking immobilized Di- and triarylphosphine palladium catalysts for continuous-flow cross-coupling reactions: efficiency, durability, and metal leaching studies. ACS Catalysis, 5 (2), 1303-1312. doi: 10.1021/cs5020089

Immobilized transition metals as catalysts for cross-couplings in continuous flow-a critical assessment of the reaction mechanism and metal leaching

Cantillo, David and Kappe, C. Oliver (2014). Immobilized transition metals as catalysts for cross-couplings in continuous flow-a critical assessment of the reaction mechanism and metal leaching. ChemCatChem, 6 (12), 3286-3305. doi: 10.1002/cctc.201402483

Sequential nitration/hydrogenation protocol for the synthesis of triaminophloroglucinol: safe generation and use of an explosive intermediate under continuous-flow conditions

Cantillo, David, Damm, Markus, Dallinger, Doris, Bauser, Marcus, Berger, Markus and Kappe, C. Oliver (2014). Sequential nitration/hydrogenation protocol for the synthesis of triaminophloroglucinol: safe generation and use of an explosive intermediate under continuous-flow conditions. Organic Process Research and Development, 18 (11), 1360-1366. doi: 10.1021/op5001435

A continuous-flow protocol for light-induced benzylic fluorinations

Cantillo, David, de Frutos, Oscar, Rincon, Juan A., Mateos, Carlos and Kappe, C. Oliver (2014). A continuous-flow protocol for light-induced benzylic fluorinations. The Journal of Organic Chemistry, 79 (17), 8486-8490. doi: 10.1021/jo5016757

Stepwise formation of 1,3-diazolium-4-thiolates by munchnone cycloadditions: promising candidates for nonlinear optics

Cantillo, David, Avalos, Martin, Babiano, Reyes, Cintas, Pedro, Jimenez, Jose L., Light, Mark E., Palacios, Juan C. and Porro, Rocio (2014). Stepwise formation of 1,3-diazolium-4-thiolates by munchnone cycloadditions: promising candidates for nonlinear optics. The Journal of Organic Chemistry, 79 (9), 4201-4205. doi: 10.1021/jo500349g

Continuous flow α-trifluoromethylation of ketones by metal-free visible light photoredox catalysis

Cantillo, David, de Frutos, Oscar, Rincon, Juan A., Mateos, Carlos and Kappe, C. Oliver (2014). Continuous flow α-trifluoromethylation of ketones by metal-free visible light photoredox catalysis. Organic Letters, 16 (3), 896-899. doi: 10.1021/ol403650y

Effect of configuration of 2-vinyldiazocarbonyl compounds on their reactivity: experimental and computational study

Supurgibekov, Murat B., Cantillo, David, Kappe, C. Oliver, Prakash, G. K. Surya and Nikolaev, Valerij A. (2014). Effect of configuration of 2-vinyldiazocarbonyl compounds on their reactivity: experimental and computational study. Organic and Biomolecular Chemistry, 12 (4), 682-689. doi: 10.1039/c3ob42102c

A scalable procedure for light-induced benzylic brominations in continuous flow

Cantillo, David, de Frutos, Oscar, Rincon, Juan A., Mateos, Carlos and Kappe, C. Oliver (2014). A scalable procedure for light-induced benzylic brominations in continuous flow. The Journal of Organic Chemistry, 79 (1), 223-229. doi: 10.1021/jo402409k

Direct preparation of nitriles from carboxylic acids in continuous flow

Cantillo, David and Kappe, C. Oliver (2013). Direct preparation of nitriles from carboxylic acids in continuous flow. The Journal of Organic Chemistry, 78 (20), 10567-10571. doi: 10.1021/jo401945r

In situ generation of diimide from hydrazine and oxygen: continuous-flow transfer hydrogenation of olefins

Pieber, Bartholomaeus, Martinez, Sabrina Teixeira, Cantillo, David and Kappe, C. Oliver (2013). In situ generation of diimide from hydrazine and oxygen: continuous-flow transfer hydrogenation of olefins. Angewandte Chemie (International Edition), 52 (39), 10241-10244. doi: 10.1002/anie.201303528

Hydrazine-mediated Reduction of Nitro and Azide Functionalities Catalyzed by Highly Active and Reusable Magnetic Iron Oxide Nanocrystals

Cantillo, David, Moghaddam, Mojtaba Mirhosseini and Kappe, C. Oliver (2013). Hydrazine-mediated Reduction of Nitro and Azide Functionalities Catalyzed by Highly Active and Reusable Magnetic Iron Oxide Nanocrystals. Journal of Organic Chemistry, 78 (9), 4530-4542. doi: 10.1021/jo400556g

On the Fischer indole synthesis of 7-ethyltryptophol-mechanistic and process intensification studies under continuous flow conditions

Gutmann, Bernhard, Gottsponer, Michael, Elsner, Petteri, Cantillo, David, Roberge, Dominique M. and Kappe, C. Oliver (2013). On the Fischer indole synthesis of 7-ethyltryptophol-mechanistic and process intensification studies under continuous flow conditions. Organic Process Research and Development, 17 (2), 294-302. doi: 10.1021/op300363s

An experimental and computational assessment of acid-catalyzed azide-nitrile cycloadditions

Cantillo, David, Gutmann, Bernhard and Kappe, C. Oliver (2012). An experimental and computational assessment of acid-catalyzed azide-nitrile cycloadditions. The Journal of Organic Chemistry, 77 (23), 10882-10890. doi: 10.1021/jo3022742

Can electromagnetic fields influence the structure and enzymatic digest of proteins? A critical evaluation of microwave-assisted proteomics protocols

Damm, Markus, Nusshold, Christoph, Cantillo, David, Rechberger, Gerald N., Gruber, Karl, Sattler, Wolfgang and Kappe, C. Oliver (2012). Can electromagnetic fields influence the structure and enzymatic digest of proteins? A critical evaluation of microwave-assisted proteomics protocols. Journal of Proteomics, 75 (18), 5533-5543. doi: 10.1016/j.jprot.2012.07.043

On the prebiotic synthesis of D-sugars catalyzed by L-peptides: assessments from first-principles calculations

Cantillo, David, Avalos, Martin, Babiano, Reyes, Cintas, Pedro, Jimenez, Jose L. and Palacios, Juan C. (2012). On the prebiotic synthesis of D-sugars catalyzed by L-peptides: assessments from first-principles calculations. Chemistry: A European Journal, 18 (28), 8795-8799. doi: 10.1002/chem.201200466

Direct arylation of benzene with aryl bromides using high-temperature/high-pressure process windows: expanding the scope of C-H activation chemistry

Pieber, Bartholomaus, Cantillo, David and Kappe, C. Oliver (2012). Direct arylation of benzene with aryl bromides using high-temperature/high-pressure process windows: expanding the scope of C-H activation chemistry. Chemistry: A European Journal, 18 (16), 5047-5055. doi: 10.1002/chem.201103748

Flash flow pyrolysis: mimicking flash vacuum pyrolysis in a high-temperature/high-pressure liquid-phase microreactor environment

Cantillo, David, Sheibani, Hassan and Kappe, C. Oliver (2012). Flash flow pyrolysis: mimicking flash vacuum pyrolysis in a high-temperature/high-pressure liquid-phase microreactor environment. The Journal of Organic Chemistry, 77 (5), 2463-2473. doi: 10.1021/jo3001645

Fast and reliable location of stationary points in a reaction path

Cantillo, David, Avalos, Martin, Babiano, Reyes, Cintas, Pedro, Jimenez, Jose L. and Palacios, Juan C. (2012). Fast and reliable location of stationary points in a reaction path. Journal of Physical Organic Chemistry, 25 (1), 77-82. doi: 10.1002/poc.1877

In situ generated iron oxide nanocrystals as efficient and selective catalysts for the reduction of nitroarenes using a continuous flow method

Cantillo, David, Baghbanzadeh, Mostafa and Kappe, C. Oliver (2012). In situ generated iron oxide nanocrystals as efficient and selective catalysts for the reduction of nitroarenes using a continuous flow method. Angewandte Chemie (International Edition), 51 (40), 10190-10193. doi: 10.1002/anie.201205792

On the mechanism of the Dakin-West reaction

Dalla-Vechia, Luciana, Santos, Vanessa G., Godoi, Marla N., Cantillo, David, Kappe, C. Oliver, Eberlin, Marcos N., de Souza, Rodrigo O. M. A. and Miranda, Leandro S. M. (2012). On the mechanism of the Dakin-West reaction. Organic and Biomolecular Chemistry, 10 (45), 9013-9020. doi: 10.1039/c2ob26560e

Mechanistic insights on the ruthenium-catalyzed hydrogenation of amides - C-N vs. C-O cleavage

Cantillo, David (2011). Mechanistic insights on the ruthenium-catalyzed hydrogenation of amides - C-N vs. C-O cleavage. European Journal of Inorganic Chemistry, 2011 (19), 3008-3013. doi: 10.1002/ejic.201100443

Mechanistic insights on azide-nitrile cycloadditions: On the dialkyltin oxide-trimethylsilyl azide route and a new vilsmeier-haack-type organocatalyst

Cantillo, David, Gutmann, Bernhard and Kappe, C. Oliver (2011). Mechanistic insights on azide-nitrile cycloadditions: On the dialkyltin oxide-trimethylsilyl azide route and a new vilsmeier-haack-type organocatalyst. Journal of the American Chemical Society, 133 (12), 4465-4475. doi: 10.1021/ja109700b

Assessing the whole range of CuAAC mechanisms by DFT calculations-on the intermediacy of copper acetylides

Cantillo, David, Avalos, Martin, Babiano, Reyes, Cintas, Pedro, Jimenez, Jose L. and Palacios, Juan C. (2011). Assessing the whole range of CuAAC mechanisms by DFT calculations-on the intermediacy of copper acetylides. Organic and Biomolecular Chemistry, 9 (8), 2952-2958. doi: 10.1039/c0ob01001d

On the enhanced reactivity and selectivity of triazole formation in molecular flasks. A theoretical rationale

Cantillo, David, Avalos, Martin, Babiano, Reyes, Cintas, Pedro, Jimenez, Jose L. and Palacios, Juan C. (2011). On the enhanced reactivity and selectivity of triazole formation in molecular flasks. A theoretical rationale. Organic and Biomolecular Chemistry, 9 (22), 7638-7642. doi: 10.1039/c1ob06206a

A unified mechanistic view on the Morita-Baylis-Hillman reaction: computational and experimental investigations

Cantillo, David and Kappe, C. Oliver (2010). A unified mechanistic view on the Morita-Baylis-Hillman reaction: computational and experimental investigations. The Journal of Organic Chemistry, 75 (24), 8615-8626. doi: 10.1021/jo102094h

Unusual aryl migration in a mesmeric betaine in the solid and liquid state: mechanistic insights into the SNAr reaction

Cantillo, David, Avalos, Martin, Babiano, Reyes, Cintas, Pedro, Jimenez, Jose L., Light, Mark E. and Palacios, Juan C. (2010). Unusual aryl migration in a mesmeric betaine in the solid and liquid state: mechanistic insights into the SNAr reaction. The Journal of Organic Chemistry, 75 (12), 4300-4303. doi: 10.1021/jo100350t

Push-pull 1,3-thiazolium-5-thiolates. Formation via concerted and stepwise pathways, and theoretical evaluation of NLO properties

Cantillo, David, Avalos, Martin, Babiano, Reyes, Cintas, Pedro, Jimenez, Jose L., Light, Mark E., Palacios, Juan C. and Rodriguez, Valentin (2010). Push-pull 1,3-thiazolium-5-thiolates. Formation via concerted and stepwise pathways, and theoretical evaluation of NLO properties. Organic and Biomolecular Chemistry, 8 (23), 5367-5374. doi: 10.1039/c0ob00416b

Dissecting competitive mechanisms: thionation vs. cycloaddition in the reaction of thioisomunchnones with isothiocyanates under microwave irradiation

Cantillo, David, Avalos, Martin, Babiano, Reyes, Cintas, Pedro, Jimenez, Jose L., Light, Mark E. and Palacios, Juan C. (2009). Dissecting competitive mechanisms: thionation vs. cycloaddition in the reaction of thioisomunchnones with isothiocyanates under microwave irradiation. The Journal of Organic Chemistry, 74 (20), 7644-7650. doi: 10.1021/jo900960a

Thionation of mesoionics with isothiocyanates: evidence supporting a four-step domino process and ruling out a [2+2] mechanism

Cantillo, David, Avalos, Martin, Babiano, Reyes, Cintas, Pedro, Jimenez, Jose L., Light, Mark E. and Palacios, Juan C. (2009). Thionation of mesoionics with isothiocyanates: evidence supporting a four-step domino process and ruling out a [2+2] mechanism. The Journal of Organic Chemistry, 74 (10), 3698-3705. doi: 10.1021/jo900028c

Stepwise cycloadditions of mesoionic systems: thionation of thioisomunchnones by isothlocyanates

Cantillo, David, Avalos, Martin, Babiano, Reyes, Cintas, Pedro, Jimenez, Jose L., Light, Mark E. and Palacios, Juan C. (2008). Stepwise cycloadditions of mesoionic systems: thionation of thioisomunchnones by isothlocyanates. Organic Letters, 10 (6), 1079-1082. doi: 10.1021/ol702929k

Continuous flow synthesis of 1,4-benzoxazinones via a fully integrated nitration/hydrogenation/cyclization sequence

Cantillo, David, Wolf, Bernd, Goetz, Roland and Kappe, C. (2017). Continuous flow synthesis of 1,4-benzoxazinones via a fully integrated nitration/hydrogenation/cyclization sequence. 254th National Meeting and Exposition of the American-Chemical-Society (ACS) on Chemistry's Impact on the Global Economy, Washington, DC United States, 20-24 August 2017. Washington, DC United States: American Chemical Society.

α-Trifluoromethylation of ketones by metal-free visible light photoredox catalysis: Batch and continuous flow strategies

Kappe, C. Oliver and Cantillo, David (2014). α-Trifluoromethylation of ketones by metal-free visible light photoredox catalysis: Batch and continuous flow strategies. 248th National Meeting of the American-Chemical-Society (ACS), San Francisco, CA United States, 10-14 August 2014. Washington, DC United States: American Chemical Society.

In search for an efficient catalyst for azide-nitrile cycloadditions: The synthesis of 5-substituted-1H-tetrazoles under batch and continuous flow conditions

Kappe, C. Oliver, Cantillo, David and Gutmann, Bernhard (2013). In search for an efficient catalyst for azide-nitrile cycloadditions: The synthesis of 5-substituted-1H-tetrazoles under batch and continuous flow conditions. 245th National Spring Meeting of the American-Chemical-Society (ACS), New Orleans, LA United States, 7-11 April 2013. Washington, DC United States: American Chemical Society.

In situ generated iron oxide nanocrystals as efficient and selective catalysts for the reduction of nitroarenes in batch and continuous flow formats

Kappe, C. Oliver, Cantillo, David, Baghbanzadeh, Mostafa and Moghaddam, Mojtaba Mirhosseini (2013). In situ generated iron oxide nanocrystals as efficient and selective catalysts for the reduction of nitroarenes in batch and continuous flow formats. 245th National Spring Meeting of the American-Chemical-Society (ACS), New Orleans, LA United States, 7-11 April 2013. Washington, DC United States: American Chemical Society.

Safe and scalable synthesis of 5-aryl-1H-tetrazoles in batch and continuous flow mode

Kappe, C. Oliver, Cantillo, David and Gutmann, Bernhard (2011). Safe and scalable synthesis of 5-aryl-1H-tetrazoles in batch and continuous flow mode. 242nd National Meeting of the American-Chemical-Society (ACS), Denver, CO United States, 28 August - 1 September 2011. Washington, DC United States: American Chemical Society.

Electrochemical reactor and processes using the electrochemical reactor

Kappe, Oliver, Sommer, Florian and Cantillo, David (2023). Electrochemical reactor and processes using the electrochemical reactor. WO2023180283A2.

Processes for preparing nor-opioid compounds and opioid antagonists by electrochemical N-demethylation

Glotz, Gabriel, Kappe, Christian Oliver and Cantillo, David (2021). Processes for preparing nor-opioid compounds and opioid antagonists by electrochemical N-demethylation. WO2021249708A1.

Processes and oxazolidine-containing intermediates for the preparation of morphine analogs and derivatives

Kappe, C. O., Gutmann, B., Weigl, U., Egli, P., Cox, P. D. and Cantillo, D. (2017). Processes and oxazolidine-containing intermediates for the preparation of morphine analogs and derivatives. WO2017185004.

Process for manufacturing 1,4-benzoxazinones

Wolf, Bernd, Goetz, Roland, Kappe, C. Oliver and Cantillo, David (2017). Process for manufacturing 1,4-benzoxazinones. EP3184515A1.