Postdoctoral Research Fellow
Overview
Amal specialises in investigating the therapeutic aspects of focused ultrasound-mediated gene therapy for neurodegenerative diseases. He completed his PhD (2016-2020) at CAI/AIBN (UQ) under Prof. Kristofer Thurecht, studying the effect of different ligand densities on the distribution of nanocarriers in vitro and in vivo. He joined Prof. Terry Rabbitts’s lab at the Institute of Cancer Research London as a Postdoctoral Fellow (2020-2022), working on an intracellular antibody-assisted small molecule discovery project funded by Blood Cancer UK and by the Kay Kendall Leukemia Fund. His current research focuses on the therapeutic aspects of focused ultrasound-mediated gene therapy for neurodegenerative diseases funded by the FightMND Foundation, in collaboration with Professor Kris Thurecht, Dr. Kara Vine-Perrow, Prof. Justin Yerbury, and Prof. Anthony White at the University of Queensland and the University of Wollongong.
Research Impacts
Developing ultrasound-mediated drug delivery strategies for neurodegenerative diseases using nanocarriers.
Qualifications
- Doctor of Philosophy, The University of Queensland
- Master of Technology, Amrita Institute of Medical Sciences, Amrita University
- Bachelor of Biotechnology&Biochemical Engineering, University of Kerala
Publications
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Journal Article: Effect of chain‐end chemistries on the efficiency of coupling antibodies to polymers using unnatural amino acids
Sivaram, Amal J., Wardiana, Andri, Preethi, S. S. Hema, Fuchs, Adrian V., Howard, Christopher B., Fletcher, Nicholas L., Bell, Craig A. and Thurecht, Kristofer J. (2020). Effect of chain‐end chemistries on the efficiency of coupling antibodies to polymers using unnatural amino acids. Macromolecular Rapid Communications, 41 (21) 2000294, e2000294. doi: 10.1002/marc.202000294
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Journal Article: Controlling the biological fate of micellar nanoparticles: balancing stealth and targeting
Sivaram, Amal J., Wardiana, Andri, Alcantara, Sheilajen, Sonderegger, Stefan E., Fletcher, Nicholas L., Houston, Zachary H., Howard, Christopher B., Mahler, Stephen M., Alexander, Cameron, Kent, Stephen J., Bell, Craig A. and Thurecht, Kristofer J. (2020). Controlling the biological fate of micellar nanoparticles: balancing stealth and targeting. ACS Nano, 14 (10) acsnano.0c06033, 13739-13753. doi: 10.1021/acsnano.0c06033
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Other Outputs: Design and synthesis of nanomaterials as combination therapeutics
Jayakumar Sivaram, Amal (2020). Design and synthesis of nanomaterials as combination therapeutics. PhD Thesis, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland. doi: 10.14264/uql.2020.836
Publications
Journal Article
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Sivaram, Amal J., Wardiana, Andri, Preethi, S. S. Hema, Fuchs, Adrian V., Howard, Christopher B., Fletcher, Nicholas L., Bell, Craig A. and Thurecht, Kristofer J. (2020). Effect of chain‐end chemistries on the efficiency of coupling antibodies to polymers using unnatural amino acids. Macromolecular Rapid Communications, 41 (21) 2000294, e2000294. doi: 10.1002/marc.202000294
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Controlling the biological fate of micellar nanoparticles: balancing stealth and targeting
Sivaram, Amal J., Wardiana, Andri, Alcantara, Sheilajen, Sonderegger, Stefan E., Fletcher, Nicholas L., Houston, Zachary H., Howard, Christopher B., Mahler, Stephen M., Alexander, Cameron, Kent, Stephen J., Bell, Craig A. and Thurecht, Kristofer J. (2020). Controlling the biological fate of micellar nanoparticles: balancing stealth and targeting. ACS Nano, 14 (10) acsnano.0c06033, 13739-13753. doi: 10.1021/acsnano.0c06033
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Recent advances in the generation of antibody-nanomaterial conjugates
Sivaram, Amal J, Wardiana, Andri, Howard, Christopher B, Mahler, Stephen M and Thurecht, Kristofer J (2018). Recent advances in the generation of antibody-nanomaterial conjugates. Advanced Healthcare Materials, 7 (1) 1700607. doi: 10.1002/adhm.201700607
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Skorik, Yury A., Golyshev, Anton A., Kritchenkov, Andreii S., Gasilova, Ekaterina R., Poshina, Daria N., Sivaram, Amal J. and Jayakumar, Rangasamy (2017). Development of drug delivery systems for taxanes using ionic gelation of carboxyacyl derivatives of chitosan. Carbohydrate Polymers, 162, 49-55. doi: 10.1016/j.carbpol.2017.01.025
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Geetha, P., Sivaram, Amal J., Jayakumar, R. and Gopi Mohan, C. (2016). Integration of in silico modeling, prediction by binding energy and experimental approach to study the amorphous chitin nanocarriers for cancer drug delivery. Carbohydrate Polymers, 142, 240-249. doi: 10.1016/j.carbpol.2016.01.059
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Combinatorial nanomedicines for colon cancer therapy
Anitha, A., Maya, S., Sivaram, Amal J., Mony, U. and Jayakumar, R. (2016). Combinatorial nanomedicines for colon cancer therapy. WIREs Nanomedicine and Nanobiotechnology, 8 (1), 151-159. doi: 10.1002/wnan.1353
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Nanogels for delivery, imaging and therapy
Sivaram, Amal J., Rajitha, P., Maya, S., Jayakumar, R. and Sabitha, M. (2015). Nanogels for delivery, imaging and therapy. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 7 (4), 509-533. doi: 10.1002/wnan.1328
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Sasidharan, Abhilash, Sivaram, Amal J., Retnakumari, Archana P., Chandran, Parwathy, Malarvizhi, Giridharan Loghanathan, Nair, Shantikumar and Koyakutty, Manzoor (2015). Radiofrequency ablation of drug-resistant cancer cells using molecularly targeted carboxyl-functionalized biodegradable graphene. Advanced Healthcare Materials, 4 (5), 679-684. doi: 10.1002/adhm.201400670
Other Outputs
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Design and synthesis of nanomaterials as combination therapeutics
Jayakumar Sivaram, Amal (2020). Design and synthesis of nanomaterials as combination therapeutics. PhD Thesis, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland. doi: 10.14264/uql.2020.836
