The University of Queensland

The marsupial major histocompatibility complex

Cheng, Yuanyuan, Siddle, Hannah V. and Belov, Katherine (2010). The marsupial major histocompatibility complex. Marsupial Genetics and Genomics. (pp. 339-356) edited by Janine E. Deakin, Paul D. Waters and Jennifer A. Marshall Graves. Amsterdam, Netherlands: Springer. doi: 10.1007/978-90-481-9023-2_16

In vitro competition between two transmissible cancers and potential implications for their host, the Tasmanian devil

Gérard, Anne‐Lise, Owen, Rachel S., Dujon, Antoine M., Roche, Benjamin, Hamede, Rodrigo, Thomas, Frédéric, Ujvari, Beata and Siddle, Hannah V. (2024). In vitro competition between two transmissible cancers and potential implications for their host, the Tasmanian devil. Evolutionary Applications, 17 (3) ARTN e13670. doi: 10.1111/eva.13670

Exploring the landscape of Babesia bovis vaccines: progress, challenges, and opportunities

Santos, John Harvey M., Siddle, Hannah V., Raza, Ali, Stanisic, Danielle I., Good, Michael F. and Tabor, Ala E. (2023). Exploring the landscape of Babesia bovis vaccines: progress, challenges, and opportunities. Parasites and Vectors, 16 (1) 274, 1-12. doi: 10.1186/s13071-023-05885-z

Class II transactivator induces expression of MHC-I and MHC-II in transmissible Tasmanian devil facial tumours

Ong, Chrissie E. B., Cheng, Yuanyuan, Siddle, Hannah V., Lyons, A. Bruce, Woods, Gregory M. and Flies, Andrew S. (2022). Class II transactivator induces expression of MHC-I and MHC-II in transmissible Tasmanian devil facial tumours. Open Biology, 12 (10) 220208, 1-13. doi: 10.1098/rsob.220208

Expression of the nonclassical MHC Class I, Saha-UD in the transmissible cancer Devil Facial Tumour Disease (DFTD)

Hussey, Kathryn, Caldwell, Alison, Kreiss, Alexandre, Skjødt, Karsten, Gastaldello, Annalisa, Pye, Ruth, Hamede, Rodrigo, Woods, Gregory M. and Siddle, Hannah V. (2022). Expression of the nonclassical MHC Class I, Saha-UD in the transmissible cancer Devil Facial Tumour Disease (DFTD). Pathogens, 11 (3) 351, 1-17. doi: 10.3390/pathogens11030351

Transmissible cancer evolution: the under-estimated role of environmental factors in the “Perfect Storm” theory

Tissot, Sophie, Gérard, Anne-Lise, Boutry, Justine, Dujon, Antoine M., Russel, Tracey, Siddle, Hannah, Tasiemski, Aurélie, Meliani, Jordan, Hamede, Rodrigo, Roche, Benjamin, Ujvari, Beata and Thomas, Frédéric (2022). Transmissible cancer evolution: the under-estimated role of environmental factors in the “Perfect Storm” theory. Pathogens, 11 (2) 241, 1-6. doi: 10.3390/pathogens11020241

The differentiation state of the Schwann cell progenitor drives phenotypic variation between two contagious cancers

Owen, Rachel S., Ramarathinam, Sri H., Bailey, Alistair, Gastaldello, Annalisa, Hussey, Kathryn, Skipp, Paul J., Purcell, Anthony W. and Siddle, Hannah V. (2021). The differentiation state of the Schwann cell progenitor drives phenotypic variation between two contagious cancers. PLoS Pathogens, 17 (11) e1010033, 1-23. doi: 10.1371/journal.ppat.1010033

The immunopeptidomes of two transmissible cancers and their host have a common, dominant peptide motif

Gastaldello, Annalisa, Ramarathinam, Sri H., Bailey, Alistair, Owen, Rachel, Turner, Steven, Kontouli, N., Elliott, Tim, Skipp, Paul, Purcell, Anthony W. and Siddle, Hannah V. (2021). The immunopeptidomes of two transmissible cancers and their host have a common, dominant peptide motif. Immunology, 163 (2), 169-184. doi: 10.1111/imm.13307

Darwin, the devil, and the management of transmissible cancers

Hamede, Rodrigo, Madsen, Thomas, McCallum, Hamish, Storfer, Andrew, Hohenlohe, Paul A., Siddle, Hannah, Kaufman, Jim, Giraudeau, Mathieu, Jones, Menna, Thomas, Frédéric and Ujvari, Beata (2021). Darwin, the devil, and the management of transmissible cancers. Conservation Biology, 35 (2), 748-751. doi: 10.1111/cobi.13644

The ecology and evolution of wildlife cancers: Applications for management and conservation

Hamede, Rodrigo, Owen, Rachel, Siddle, Hannah, Peck, Sarah, Jones, Menna, Dujon, Antoine M., Giraudeau, Mathieu, Roche, Benjamin, Ujvari, Beata and Thomas, Frédéric (2020). The ecology and evolution of wildlife cancers: Applications for management and conservation. Evolutionary Applications, 13 (7), 1719-1732. doi: 10.1111/eva.12948

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

Burr, Marian L., Sparbier, Christina E., Chan, Kah Lok, Chan, Yih-Chih, Kersbergen, Ariena, Lam, Enid Y.N., Azidis-Yates, Elizabeth, Vassiliadis, Dane, Bell, Charles C., Gilan, Omer, Jackson, Susan, Tan, Lavinia, Wong, Stephen Q., Hollizeck, Sebastian, Michalak, Ewa M., Siddle, Hannah V., McCabe, Michael T., Prinjha, Rab K., Guerra, Glen R., Solomon, Benjamin J., Sandhu, Shahneen, Dawson, Sarah-Jane, Beavis, Paul A., Tothill, Richard W., Cullinane, Carleen, Lehner, Paul J., Sutherland, Kate D. and Dawson, Mark A. (2019). An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer. Cancer Cell, 36 (4), 385-401.e8. doi: 10.1016/j.ccell.2019.08.008

Tracing the rise of malignant cell lines: Distribution, epidemiology and evolutionary interactions of two transmissible cancers in Tasmanian devils

James, Samantha, Jennings, Geordie, Kwon, Young Mi, Stammnitz, Maximilian, Fraik, Alexandra, Storfer, Andrew, Comte, Sebastien, Pemberton, David, Fox, Samantha, Brown, Bill, Pye, Ruth, Woods, Gregory, Lyons, Bruce, Hohenlohe, Paul A., McCallum, Hamish, Siddle, Hannah, Thomas, Frédéric, Ujvari, Beata, Murchison, Elizabeth P., Jones, Menna and Hamede, Rodrigo (2019). Tracing the rise of malignant cell lines: Distribution, epidemiology and evolutionary interactions of two transmissible cancers in Tasmanian devils. Evolutionary Applications, 12 (9), 1772-1780. doi: 10.1111/eva.12831

Devil facial tumours: towards a vaccine

Owen, Rachel S. and Siddle, Hannah V. (2019). Devil facial tumours: towards a vaccine. Immunological Investigations, 48 (7), 719-736. doi: 10.1080/08820139.2019.1624770

The ERBB-STAT3 axis drives Tasmanian devil facial tumor disease

Kosack, Lindsay, Wingelhofer, Bettina, Popa, Alexandra, Orlova, Anna, Agerer, Benedikt, Vilagos, Bojan, Majek, Peter, Parapatics, Katja, Lercher, Alexander, Ringler, Anna, Klughammer, Johanna, Smyth, Mark, Khamina, Kseniya, Baazim, Hatoon, de Araujo, Elvin D., Rosa, David A., Park, Jisung, Tin, Gary, Ahmar, Siawash, Gunning, Patrick T., Bock, Christoph, Siddle, Hannah V., Woods, Gregory M., Kubicek, Stefan, Murchison, Elizabeth P., Bennett, Keiryn L., Moriggl, Richard and Bergthaler, Andreas (2019). The ERBB-STAT3 axis drives Tasmanian devil facial tumor disease. Cancer Cell, 35 (1), 125-139.e9. doi: 10.1016/j.ccell.2018.11.018

The newly-arisen devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer

Caldwell, Alison, Coleby, Rachel, Tovar, Cesar, Stammnitz, Maximilian R., Mi Kwon, Young, Owen, Rachel S., Tringides, Marios, Murchison, Elizabeth P., Skjødt, Karsten, Thomas, Gareth J., Kaufman, Jim, Elliott, Tim, Woods, Gregory M. and Siddle, Hannah V. T. (2018). The newly-arisen devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer. eLife, 7 e35314, 1-18. doi: 10.7554/eLife.35314

The Origins and Vulnerabilities of Two Transmissible Cancers in Tasmanian Devils

Stammnitz, Maximilian R., Coorens, Tim H.H., Gori, Kevin C., Hayes, Dane, Fu, Beiyuan, Wang, Jinhong, Martin-Herranz, Daniel E., Alexandrov, Ludmil B., Baez-Ortega, Adrian, Barthorpe, Syd, Beck, Alexandra, Giordano, Francesca, Knowles, Graeme W., Kwon, Young Mi, Hall, George, Price, Stacey, Pye, Ruth J., Tubio, Jose M.C., Siddle, Hannah V. T., Sohal, Sukhwinder Singh, Woods, Gregory M., McDermott, Ultan, Yang, Fengtang, Garnett, Mathew J., Ning, Zemin and Murchison, Elizabeth P. (2018). The Origins and Vulnerabilities of Two Transmissible Cancers in Tasmanian Devils. Cancer Cell, 33 (4), 607-619.e15. doi: 10.1016/j.ccell.2018.03.013

The role of MHC genes in contagious cancer: the story of Tasmanian devils

Caldwell, Alison and Siddle, Hannah V. (2017). The role of MHC genes in contagious cancer: the story of Tasmanian devils. Immunogenetics, 69 (8-9), 537-545. doi: 10.1007/s00251-017-0991-9

Cancer as a contagious disease

Siddle, H. V. (2017). Cancer as a contagious disease. HLA, 89 (4), 209-214. doi: 10.1111/tan.12980

Regression of devil facial tumour disease following immunotherapy in immunised Tasmanian devils

Tovar, Cesar, Pye, Ruth J., Kreiss, Alexandre, Cheng, Yuanyuan, Brown, Gabriella K., Darby, Jocelyn, Malley, Roslyn C., Siddle, Hannah V. T., Skjodt, Karsten, Kaufman, Jim, Silva, Anabel, Morelli, Adriana Baz, Papenfuss, Anthony T., Corcoran, Lynn M., Murphy, James M., Pearse, Martin J., Belov, Katherine, Lyons, A. Bruce and Woods, Gregory M. (2017). Regression of devil facial tumour disease following immunotherapy in immunised Tasmanian devils. Scientific Reports, 7 (1) 43827, 1-14. doi: 10.1038/srep43827

Demonstration of immune responses against devil facial tumour disease in wild Tasmanian devils

Pye, Ruth, Hamede, Rodrigo, Siddle, Hannah V., Caldwell, Alison, Knowles, Graeme W., Swift, Kate, Kreiss, Alexandre, Jones, Menna E., Lyons, A Bruce and Woods, Gregory M. (2016). Demonstration of immune responses against devil facial tumour disease in wild Tasmanian devils. Biology Letters, 12 (10) 20160553, 1-5. doi: 10.1098/rsbl.2016.0553

A second transmissible cancer in Tasmanian devils

Pye, Ruth J., Pemberton, David, Tovar, Cesar, Tubio, Jose M. C., Dun, Karen A., Fox, Samantha, Darby, Jocelyn, Hayes, Dane, Knowles, Graeme W., Kreiss, Alexandre, Siddle, Hannah V. T., Swift, Kate, Lyons, A. Bruce, Murchison, Elizabeth P. and Woods, Gregory M. (2016). A second transmissible cancer in Tasmanian devils. Proceedings of the National Academy of Sciences of the United States of America, 113 (2), 374-379. doi: 10.1073/pnas.1519691113

Immunology of naturally transmissible tumours

Siddle, Hannah V. and Kaufman, Jim (2015). Immunology of naturally transmissible tumours. Immunology, 144 (1), 11-20. doi: 10.1111/imm.12377

How the devil facial tumor disease escapes host immune responses

Siddle, Hannah V. and Kaufman, Jim (2013). How the devil facial tumor disease escapes host immune responses. OncoImmunology, 2 (8) e25235. doi: 10.4161/onci.25235

A tale of two tumours: comparison of the immune escape strategies of contagious cancers

Siddle, Hannah V. and Kaufman, Jim (2013). A tale of two tumours: comparison of the immune escape strategies of contagious cancers. Molecular Immunology, 55 (2), 190-193. doi: 10.1016/j.molimm.2012.10.017

Reversible epigenetic down-regulation of MHC molecules by devil facial tumour disease illustrates immune escape by a contagious cancer

Siddle, Hannah V., Kreiss, Alexandre, Tovar, Cesar, Yuen, Chun Kit, Cheng, Yuanyuan, Belov, Katherine, Swift, Kate, Pearse, Anne-Maree, Hamede, Rodrigo, Jones, Menna E., Skjodt, Karsten, Woods, Gregory M. and Kaufman, Jim (2013). Reversible epigenetic down-regulation of MHC molecules by devil facial tumour disease illustrates immune escape by a contagious cancer. Proceedings of the National Academy of Sciences of the United States of America, 110 (13), 5103-5108. doi: 10.1073/pnas.1219920110

Antigen-presenting genes and genomic copy number variations in the Tasmanian devil MHC

Cheng, Yuanyuan, Stuart, Andrew, Morris, Katrina, Taylor, Robyn, Siddle, Hannah, Deakin, Janine, Jones, Menna, Amemiya, Chris T. and Belov, Katherine (2012). Antigen-presenting genes and genomic copy number variations in the Tasmanian devil MHC. BMC Genomics, 13 (87) 87. doi: 10.1186/1471-2164-13-87

Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development

Renfree, Marilyn B., Papenfuss, Anthony T., Deakin, Janine E., Lindsay, James, Heider, Thomas, Belov, Katherine, Rens, Willem, Waters, Paul D., Pharo, Elizabeth A., Shaw, Geoff, Wong, Emily S. W., Lefevre, Christopher M., Nicholas, Kevin R., Kuroki, Yoko, Wakefield, Matthew J., Zenger, Kyall R., Wang, Chenwei, Ferguson-Smith, Malcolm, Nicholas, Frank W., Hickford, Danielle, Yu, Hongshi, Short, Kirsty R., Siddle, Hannah V., Frankenberg, Stephen R., Chew, Keng Yih, Menzies, Brandon R., Stringer, Jessica M., Suzuki, Shunsuke, Hore, Timothy A. ... Worley, Kim C. (2011). Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development. Genome Biology, 12 (8) R81, R81.1-R81.25. doi: 10.1186/gb-2011-12-8-r81

The tammar wallaby major histocompatibility complex shows evidence of past genomic instability

Siddle, Hannah V., Deakin, Janine E., Coggill, Penny, Whilming, Laurens, Harrow, Jennifer, Kaufman, Jim, Beck, Stephan and Belov, Katherine (2011). The tammar wallaby major histocompatibility complex shows evidence of past genomic instability. BMC Genomics, 12 421. doi: 10.1186/1471-2164-12-421

MHC gene copy number variation in Tasmanian devils: Implications for the spread of a contagious cancer

Siddle, Hannah V., Marzec, Jolanta, Cheng, Yuanyuan, Jones, Menna and Belov, Katherine (2010). MHC gene copy number variation in Tasmanian devils: Implications for the spread of a contagious cancer. Proceedings of the Royal Society B-Biological Sciences, 277 (1690), 2001-2006. doi: 10.1098/rspb.2009.2362

High levels of genetic variation at MHC class II DBB loci in the tammar wallaby (Macropus eugenii)

Cheng, Yuanyuan, Siddle, Hannah V., Beck, Stephan, Eldridge, Mark D. B. and Belov, Katherine (2009). High levels of genetic variation at MHC class II DBB loci in the tammar wallaby (Macropus eugenii). Immunogenetics, 61 (2), 111-118. doi: 10.1007/s00251-008-0347-6

MHC-linked and un-linked class I genes in the wallaby

Siddle, Hannah V., Deakin, Janine E., Coggill, Penny, Hart, Elizabeth, Cheng, Yuanyuan, Wong, Emily S. W., Harrow, Jennifer, Beck, Stephan and Belov, Katherine (2009). MHC-linked and un-linked class I genes in the wallaby. BMC Genomics, 10 (1) 310, 1-15. doi: 10.1186/1471-2164-10-310

Isolation and characterization of 10 MHC Class I-associated microsatellite loci in tammar wallaby (Macropus eugenii)

Cheng, Yuanyuan, Wakefield, Matthew, Siddle, Hannah V., Coggill, Penny C., Herbert, Cathy A., Beck, Stephan, Belov, Katherine and Eldridge, Mark D. B. (2009). Isolation and characterization of 10 MHC Class I-associated microsatellite loci in tammar wallaby (Macropus eugenii). Molecular Ecology Resources, 9 (1), 346-349. doi: 10.1111/j.1755-0998.2008.02401.x

Transmission of a fatal clonal tumor by biting occurs due to depleted MHC diversity in a threatened carnivorous marsupial

Siddle, Hannah V., Kreiss, Alexandre, Eldridge, Mark D. B., Noonan, Erin, Clarke, Candice J., Pyecroft, Stephen, Woods, Gregory M. and Belov, Katherine (2007). Transmission of a fatal clonal tumor by biting occurs due to depleted MHC diversity in a threatened carnivorous marsupial. Proceedings of the National Academy of Sciences of the United States of America, 104 (41), 16221-16226. doi: 10.1073/pnas.0704580104

Characterization of major histocompatibility complex class I and class II genes from the Tasmanian devil (Sarcophilus harrisii)

Siddle, Hannah V., Sanderson, Claire and Belov, Katherine (2007). Characterization of major histocompatibility complex class I and class II genes from the Tasmanian devil (Sarcophilus harrisii). Immunogenetics, 59 (9), 753-760. doi: 10.1007/s00251-007-0238-2

The immune response of the Tasmanian devil (Sarcophilus harrisii) and devil facial tumour disease-t

Woods, Gregory M., Kreiss, Alexandre, Belov, Katherine, Siddle, Hannah V., Obendorf, David L. and Muller, H. Konrad (2007). The immune response of the Tasmanian devil (Sarcophilus harrisii) and devil facial tumour disease-t. EcoHealth, 4 (3), 338-345. doi: 10.1007/s10393-007-0117-1

Class I genes have split from the MHC in the tammar wallaby

Deakin, J. E., Siddle, H. V., Cross, J. G.R., Belov, K. and Graves, J. A.M. (2007). Class I genes have split from the MHC in the tammar wallaby. Cytogenetic and Genome Research, 116 (3), 205-211. doi: 10.1159/000098188

Isolation of major histocompatibility complex Class I genes from the tammar wallaby (Macropus eugenii)

Siddle, Hannah V., Deakin, Janine E., Baker, Michelle L., Miller, Robert D. and Belov, Katherine (2006). Isolation of major histocompatibility complex Class I genes from the tammar wallaby (Macropus eugenii). Immunogenetics, 58 (5-6), 487-493. doi: 10.1007/s00251-006-0107-4

Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex

Belov, Katherine, Deakin, Janine E., Papenfuss, Anthony T., Baker, Michelle L., Melman, Sandra D., Siddle, Hannah V., Gouin, Nicolas, Goode, David L., Sargeant, Tobias J., Robinson, Mark D., Wakefield, Matthew J., Mahony, Shaun, Cross, Joseph G. R., Benos, Panayiotis V., Samollow, Paul B., Speed, Terence P., Marshall Graves, Jennifer A. and Miller, Robert D. (2006). Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex. PLoS Biology, 4 (3) 46, 0317-0328. doi: 10.1371/journal.pbio.0040046

New diagnostic tools for bovine vibriosis

Tabor, Ala, Siddle, Hannah, Juli, Sogra Banu, Raza, Ali, Ong, Chian Teng, McCosker, Kieren, Hayes, Ben and Boe-Hansen, Gry (2023). New diagnostic tools for bovine vibriosis. Northern Beef Research Update Conference, Darwin, NT Australia, 22-25 August 2023.