The University of Queensland

Management of high genetic risk bowel cancer

Leggett, Barbara (2010). Management of high genetic risk bowel cancer. When Cancer Crosses Disciplines: A Clinician's Handbook. (pp. 969-979) edited by Monica C. Robotin, Ian N. Olver and Afaf Girgis. London, UK: Imperial College Press.

Spontaneous remission of Cronkhite-Canada syndrome without immunosuppressive medication in the context of decompensated cirrhosis: A case report

Deacon, Anthony J., Hoey, Paris, Grimpen, Florian, Francis, Leo, Brown, Ian and Leggett, Barbara (2024). Spontaneous remission of Cronkhite-Canada syndrome without immunosuppressive medication in the context of decompensated cirrhosis: A case report. Clinical Case Reports, 12 (6) e8985, e8985. doi: 10.1002/ccr3.8985

Efficacy, safety, and pharmacokinetics of capsid assembly modulator linvencorvir plus standard of care in chronic hepatitis B patients

Hou, Jinlin, Gane, Edward, Balabanska, Rozalina, Zhang, Wenhong, Zhang, Jiming, Lim, Tien Huey, Xie, Qing, Yeh, Chau-Ting, Yang, Sheng-Shun, Liang, Xieer, Komolmit, Piyawat, Leerapun, Apinya, Xue, Zenghui, Chen, Ethan, Zhang, Yuchen, Xie, Qiaoqiao, Chang, Ting-Tsung, Hu, Tsung-Hui, Lim, Seng Gee, Chuang, Wan-Long, Leggett, Barbara, Bo, Qingyan, Zhou, Xue, Triyatni, Miriam, Zhang, Wen and Yuen, Man-Fung (2024). Efficacy, safety, and pharmacokinetics of capsid assembly modulator linvencorvir plus standard of care in chronic hepatitis B patients. Clinical and Molecular Hepatology, 30 (2), 191-205. doi: 10.3350/cmh.2023.0422

Broadening and strengthening the health providers caring for patients with chronic hepatitis C may improve continuity of care

Clark, Paul J., Valery, Patricia C., Strasser, Simone I., Weltman, Martin, Thompson, Alex, Levy, Miriam T., Leggett, Barbara, Zekry, Amany, Rong, Julian, Sinclair, Marie, George, Jacob, Bollipo, Steven, McGarity, Bruce, Sievert, William, MacQuillan, Gerry, Tse, Edmund, Nicoll, Amanda, Wade, Amanda, Cheng, Wendy and Roberts, Stuart K. (2024). Broadening and strengthening the health providers caring for patients with chronic hepatitis C may improve continuity of care. Journal of Gastroenterology and Hepatology, 39 (3), 568-575. doi: 10.1111/jgh.16440

Improving palliative and supportive care in advanced cirrhosis: the HepatoCare model of integrated collaborative care

Kearney, Alison, Tiwari, Neha, Cullen, Olivia, Legg, Amy, Arbi, Ismail, Douglas, Carol, Leggett, Barbara, Fenech, Mary, Mina, Joanne, Hoey, Paris and Skoien, Richard (2023). Improving palliative and supportive care in advanced cirrhosis: the HepatoCare model of integrated collaborative care. Internal Medicine Journal, 53 (11), 1963-1971. doi: 10.1111/imj.16248

Diabetes mellitus and the progression of non‐alcoholic fatty liver disease to decompensated cirrhosis: a retrospective cohort study

O'Beirne, James, Skoien, Richard, Leggett, Barbara A., Hartel, Gunter F., Gordon, Louisa G., Powell, Elizabeth E. and Valery, Patricia C. (2023). Diabetes mellitus and the progression of non‐alcoholic fatty liver disease to decompensated cirrhosis: a retrospective cohort study. Medical Journal of Australia, 219 (8), 358-365. doi: 10.5694/mja2.52104

Seladelpar efficacy and safety at 3 months in patients with primary biliary cholangitis: ENHANCE, a phase 3, randomized, placebo-controlled study

Hirschfield, Gideon M., Shiffman, Mitchell L., Gulamhusein, Aliya, Kowdley, Kris V., Vierling, John M., Levy, Cynthia, Kremer, Andreas E., Zigmond, Ehud, Andreone, Pietro, Gordon, Stuart C., Bowlus, Christopher L., Lawitz, Eric J., Aspinall, Richard J., Pratt, Daniel S., Raikhelson, Karina, Gonzalez-Huezo, Maria S., Heneghan, Michael A., Jeong, Sook-Hyang, Ladrón de Guevara, Alma L., Mayo, Marlyn J., Dalekos, George N., Drenth, Joost P H, Janczewska, Ewa, Leggett, Barbara A., Nevens, Frederik, Vargas, Victor, Zuckerman, Eli, Corpechot, Christophe, Fassio, Eduardo ... McWherter, Charles A. (2023). Seladelpar efficacy and safety at 3 months in patients with primary biliary cholangitis: ENHANCE, a phase 3, randomized, placebo-controlled study. Hepatology, 78 (2), 397-415. doi: 10.1097/HEP.0000000000000395

Post-colonoscopy cancer rate at a tertiary referral hospital in Australia: a data linkage analysis

Lamba, Mehul, Khaing, Myat Myat, Ma, Xiaomin, Ryan, Kimberley, Appleyard, Mark, Leggett, Barbara and Grimpen, Florian (2023). Post-colonoscopy cancer rate at a tertiary referral hospital in Australia: a data linkage analysis. Journal of Gastroenterology and Hepatology, 38 (5), 740-746. doi: 10.1111/jgh.16077

Comparative analysis of Illumina Mouse Methylation BeadChip and reduced-representation bisulfite sequencing for routine DNA methylation analysis

Fennell, Lochlan J., Hartel, Gunter, McKeone, Diane M., Bond, Catherine E., Kane, Alexandra, Leggett, Barbara A., Patch, Ann-Marie and Whitehall, Vicki L.J. (2022). Comparative analysis of Illumina Mouse Methylation BeadChip and reduced-representation bisulfite sequencing for routine DNA methylation analysis. Cell Reports Methods, 2 (11) 100323, 1-14. doi: 10.1016/j.crmeth.2022.100323

Clinicopathological correlates of dysplastic sessile serrated lesion: a prospective cohort study with a high detection rate

Lamba, Mehul, Brown, Ian, Bettington, Mark, Ryan, Kimberley, Hanigan, Katherine, Lasenby, Kay, Dixon, Alicia, Grimpen, Florian, Gan, Chun, Tutticci, Nicholas, Appleyard, Mark and Leggett, Barbara (2022). Clinicopathological correlates of dysplastic sessile serrated lesion: a prospective cohort study with a high detection rate. Gastro Hep Advances, 1 (3), 313-320. doi: 10.1016/j.gastha.2021.12.010

Braf mutation induces rapid neoplastic transformation in the aged and aberrantly methylated intestinal epithelium

Fennell, Lochlan, Kane, Alexandra, Liu, Cheng, McKeone, Diane, Hartel, Gunter, Su, Chang, Bond, Catherine, Bettington, Mark, Leggett, Barbara and Whitehall, Vicki (2021). Braf mutation induces rapid neoplastic transformation in the aged and aberrantly methylated intestinal epithelium. Gut, 71 (6) 322166, 1127-1140. doi: 10.1136/gutjnl-2020-322166

Association of Fusobacterium nucleatum with specific T-cell subsets in the colorectal carcinoma microenvironment

Borowsky, Jennifer, Haruki, Koichiro, Lau, Mai Chan, Costa, Andressa Dias, Vayrynen, Juha P., Ugai, Tomotaka, Arima, Kota, Da Silva, Annacarolina, Felt, Kristen D., Zhao, Melissa, Gurjao, Carino, Twombly, Tyler S., Fujiyoshi, Kenji, Vayrynen, Sara A., Hamada, Tsuyoshi, Mima, Kosuke, Bullman, Susan, Harrison, Tabitha A., Phipps, Amanda I., Peters, Ulrike, Ng, Kimmie, Meyerhardt, Jeffrey A., Song, Mingyang, Giovannucci, Edward L., Wu, Kana, Zhang, Xuehong, Freeman, Gordon J., Huttenhower, Curtis, Garrett, Wendy S. ... Ogino, Shuji (2021). Association of Fusobacterium nucleatum with specific T-cell subsets in the colorectal carcinoma microenvironment. Clinical Cancer Research, 27 (10), 2816-2826. doi: 10.1158/1078-0432.CCR-20-4009

Aspirin reduces the incidence of metastasis in a pre-clinical study of Braf mutant serrated colorectal neoplasia

Kane, Alexandra M., Liu, Cheng, Fennell, Lochlan J., McKeone, Diane M., Bond, Catherine E., Pollock, Pamela M., Young, Graeme, Leggett, Barbara A. and Whitehall, Vicki L. J. (2021). Aspirin reduces the incidence of metastasis in a pre-clinical study of Braf mutant serrated colorectal neoplasia. British Journal of Cancer, 124 (11), 1820-1827. doi: 10.1038/s41416-021-01339-4

Curcumin chemoprevention reduces the incidence of Braf mutant colorectal cancer in a preclinical study

Kane, Alexandra M., Liu, Cheng, Akhter, Dewan T., McKeone, Diane M., Bell, Craig A., Thurecht, Kristofer J., Leggett, Barbara A. and Whitehall, Vicki L. J. (2021). Curcumin chemoprevention reduces the incidence of Braf mutant colorectal cancer in a preclinical study. Digestive Diseases and Sciences, 66 (12), 4326-4332. doi: 10.1007/s10620-020-06752-y

Pathways to a cancer-free future: a protocol for modelled evaluations to minimise the future burden of colorectal cancer in Australia

Feletto, Eleonora, Lew, Jie-Bin, Worthington, Joachim, He, Emily, Caruana, Michael, Butler, Katherine, Hui, Harriet, Taylor, Natalie, Banks, Emily, Barclay, Karen, Broun, Kate, Butt, Alison, Carter, Rob, Cuff, Jeff, Dessaix, Anita, Ee, Hooi, Emery, Jon, Frayling, Ian M., Grogan, Paul, Holden, Carol, Horn, Christopher, Jenkins, Mark A., Kench, James G., Laaksonen, Maarit A., Leggett, Barbara, Mitchell, Gillian, Morris, Susan, Parkinson, Bonny, St John, D James ... Canfell, Karen (2020). Pathways to a cancer-free future: a protocol for modelled evaluations to minimise the future burden of colorectal cancer in Australia. BMJ Open, 10 (6) e036475, e036475. doi: 10.1136/bmjopen-2019-036475

APC mutation marks an aggressive subtype of BRAF mutant colorectal cancers

Fennell, Lochlan J., Kane, Alexandra, Liu, Cheng, McKeone, Diane, Fernando, Winnie, Su, Chang, Bond, Catherine, Jamieson, Saara, Dumenil, Troy, Patch, Ann-Marie, Kazakoff, Stephen H., Pearson, John V., Waddell, Nicola, Leggett, Barbara and Whitehall, Vicki L. J (2020). APC mutation marks an aggressive subtype of BRAF mutant colorectal cancers. Cancers, 12 (5) 1171, 1-26. doi: 10.3390/cancers12051171

Traditional serrated adenoma-like lesions in patients with inflammatory bowel disease:

Miller, Gregory C., Liu, Cheng, Bettington, Mark L., Leggett, Barbara, Whitehall, Vicki L.J. and Rosty, Christophe (2020). Traditional serrated adenoma-like lesions in patients with inflammatory bowel disease:. Human Pathology, 97, 19-28. doi: 10.1016/j.humpath.2019.12.005

BRAF V600E immunohistochemistry demonstrates that some sessile serrated lesions with adenomatous dysplasia may represent collision lesions

Bettington, Mark, Liu, Cheng, Gill, Anthony, Walker, Neal, Leggett, Barbara, Whitehall, Vicki and Rosty, Christophe (2019). BRAF V600E immunohistochemistry demonstrates that some sessile serrated lesions with adenomatous dysplasia may represent collision lesions. Histopathology, 75 (1), 81-87. doi: 10.1111/his.13851

DNA methylation changes that precede onset of dysplasia in advanced sessile serrated adenomas

Liu, Cheng, Fennell, Lochlan J., Bettington, Mark L., Walker, Neal I., Dwine, Joel, Leggett, Barbara A. and Whitehall, Vicki L. J. (2019). DNA methylation changes that precede onset of dysplasia in advanced sessile serrated adenomas. Clinical Epigenetics, 11 (1) 90, 90. doi: 10.1186/s13148-019-0691-4

Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis

Lannagan, Tamsin R. M., Lee, Young K., Wang, Tongtong, Roper, Jatin, Bettington, Mark L., Fennell, Lochlan, Vrbanac, Laura, Jonavicius, Lisa, Somashekar, Roshini, Gieniec, Krystyna, Yang, Miao, Ng, Jia Q., Suzuki, Nobumi, Ichinose, Mari, Wright, Josephine A., Kobayashi, Hiroki, Putoczki, Tracey L., Hayakawa, Yoku, Leedham, Simon J., Abud, Helen E., Yilmaz, Omer H., Marker, Julie, Klebe, Sonja, Wirapati, Pratyaksha, Mukherjee, Siddhartha, Tejpar, Sabine, Leggett, Barbara A., Whitehall, Vicki L. J., Worthley, Daniel L. and Woods, Susan L. (2019). Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis. Gut, 68 (4), 684-692. doi: 10.1136/gutjnl-2017-315920

Integrative genome-scale DNA methylation analysis of a large and unselected cohort reveals five distinct subtypes of colorectal adenocarcinomas

Fennell, Lochlan, Dumenil, Troy, Wockner, Leesa, Hartel, Gunter, Nones, Katia, Bond, Catherine, Borowsky, Jennifer, Liu, Cheng, McKeone, Diane, Bowdler, Lisa, Montgomery, Grant, Klein, Kerenaftali, Hoffmann, Isabell, Patch, Ann-Marie, Kazakoff, Stephen, Pearson, John, Waddell, Nicola, Wirapati, Pratyaksha, Lochhead, Paul, Imamura, Yu, Ogino, Shuji, Shao, Renfu, Tejpar, Sabine, Leggett, Barbara and Whitehall, Vicki (2019). Integrative genome-scale DNA methylation analysis of a large and unselected cohort reveals five distinct subtypes of colorectal adenocarcinomas. Cellular and Molecular Gastroenterology and Hepatology, 8 (2), 269-290. doi: 10.1016/j.jcmgh.2019.04.002

Five‐year conditional survival for patients with hepatocellular carcinoma in Queensland, Australia

Valery, Patricia C., Baade, Peter A., Stuart, Katherine A., Leggett, Barbara A., Macdonald, Graeme A., Whiteman, David C., Crawford, Darrell H. and Clark, Paul J. (2019). Five‐year conditional survival for patients with hepatocellular carcinoma in Queensland, Australia. GastroHep, 1 (2), 61-69. doi: 10.1002/ygh2.327

CpG island methylation in sessile serrated adenomas increases with age, indicating lower risk of malignancy in young patients

Liu, Cheng, Bettington, Mark L., Walker, Neal I., Dwine, Joel, Hartel, Gunter F., Leggett, Barbara A. and Whitehall, Vicki L. J. (2018). CpG island methylation in sessile serrated adenomas increases with age, indicating lower risk of malignancy in young patients. Gastroenterology, 155 (5), 1362-1365. doi: 10.1053/j.gastro.2018.07.012

NGM282 for treatment of patients with primary biliary cholangitis: a multicenter, randomized, double blind placebo controlled trial

Mayo, Marlyn J., Wigg, Alan J., Leggett, Barbara A., Arnold, Hays, Thompson, Alexander J., Weltman, Martin, Carey, Elizabeth J., Muir, Andrew J., Ling, Lei, Rossi, Stephen J. and Depaoli, Alex M. (2018). NGM282 for treatment of patients with primary biliary cholangitis: a multicenter, randomized, double blind placebo controlled trial. Hepatology Communications, 2 (9), 1037-1050. doi: 10.1002/hep4.1209

A morphological and molecular study of proposed early forms of the traditional serrated adenoma

Bettington, Mark, Rosty, Christophe, Whitehall, Vicki, Leggett, Barbara, McKeone, Diane, Pearson, Sally-Ann and Walker, Neal (2018). A morphological and molecular study of proposed early forms of the traditional serrated adenoma. Histopathology, 73 (6), 1023-1029. doi: 10.1111/his.13714

Sessile serrated adenomas in young patients may have limited risk of malignant progression

Bettington, Mark, Brown, Ian, Rosty, Christophe, Walker, Neal, Liu, Cheng, Croese, John, Rahman, Tony, Pearson, Sally-Ann, McKeone, Diane, Leggett, Barbara and Whitehall, Vicki (2018). Sessile serrated adenomas in young patients may have limited risk of malignant progression. Journal of Clinical Gastroenterology, 53 (3), 1-e116. doi: 10.1097/MCG.0000000000001014

The role of APC in WNT pathway activation in serrated neoplasia

Borowsky, Jennifer, Dumenil, Troy, Bettington, Mark, Pearson, Sally-Ann, Bond, Catherine, Fennell, Lochlan, Liu, Cheng, McKeone, Diane, Rosty, Christophe, Brown, Ian, Walker, Neal, Leggett, Barbara and Whitehall, Vicki (2018). The role of APC in WNT pathway activation in serrated neoplasia. Modern Pathology, 31 (3), 495-504. doi: 10.1038/modpathol.2017.150

Oncogenic BRAF mutation induces DNA methylation changes in a murine model for human serrated colorectal neoplasia

Bond, Catherine E., Liu, Cheng, Kawamata, Futoshi, McKeone, Diane M., Fernando, Winnie, Jamieson, Saara, Pearson, Sally-Ann, Kane, Alexandra, Woods, Susan L., Lannagan, Tamsin R. M., Somashekar, Roshini, Lee, Young, Dumenil, Troy, Hartel, Gunter, Spring, Kevin J., Borowsky, Jennifer, Fennell, Lochlan, Bettington, Mark, Lee, Jason, Worthley, Daniel L., Leggett, Barbara A. and Whitehall, Vicki L. J. (2018). Oncogenic BRAF mutation induces DNA methylation changes in a murine model for human serrated colorectal neoplasia. Epigenetics, 13 (1), 40-48. doi: 10.1080/15592294.2017.1411446

MLH1-93 G/a polymorphism is associated with MLH1 promoter methylation and protein loss in dysplastic sessile serrated adenomas with BRAFV600E mutation

Fennell, Lochlan J., Jamieson, Saara, McKeone, Diane, Corish, Tracie, Rohdmann, Megan, Furner, Tori, Bettington, Mark, Liu, Cheng, Kawamata, Futoshi, Bond, Catherine, Van De Pols, Jolieke, Leggett, Barbara and Whitehall, Vicki (2018). MLH1-93 G/a polymorphism is associated with MLH1 promoter methylation and protein loss in dysplastic sessile serrated adenomas with BRAFV600E mutation. BMC Cancer, 18 (1) 35, 1-7. doi: 10.1186/s12885-017-3946-5

Copy number profiles of paired primary and metastatic colorectal cancers

Kawamata, Futoshi, Patch, Ann-Marie, Nones, Katia, Bond, Catherine, McKeone, Diane, Pearson, Sally-Ann, Homma, Shigenori, Liu, Cheng, Fennell, Lochlan, Dumenil, Troy, Hartel, Gunter, Kobayasi, Nozomi, Yokoo, Hideki, Fukai, Moto, Nishihara, Hiroshi, Kamiyama, Toshiya, Burge, Matthew E., Karapetis, Christos S., Taketomi, Akinobu, Leggett, Barbara, Waddell, Nicola and Whitehall, Vicki (2018). Copy number profiles of paired primary and metastatic colorectal cancers. Oncotarget, 9 (3), 3394-3405. doi: 10.18632/oncotarget.23277

Sessile serrated adenomas with dysplasia: morphological patterns and correlations with MLH1 immunohistochemistry

Liu, Cheng, Walker, Neal I., Leggett, Barbara A., Whitehall, Vicki L. J., Bettington, Mark L. and Rosty, Christophe (2017). Sessile serrated adenomas with dysplasia: morphological patterns and correlations with MLH1 immunohistochemistry. Modern Pathology, 30 (12), 1728-1738. doi: 10.1038/modpathol.2017.92

RNF43 is mutated less frequently in Lynch Syndrome compared with sporadic microsatellite unstable colorectal cancers

Fennell, Lochlan J. , Clendenning, Mark, McKeone, Diane M. , Jamieson, Saara H., Balachandran, Samanthy, Borowsky, Jennifer, Liu, John, Kawamata, Futoshi, Bond, Catherine E., Rosty, Christophe, Burge, Matthew E., Buchanan, Daniel D., Leggett, Barbara A.  and Whitehall, Vicki L. J. (2017). RNF43 is mutated less frequently in Lynch Syndrome compared with sporadic microsatellite unstable colorectal cancers. Familial Cancer, 17 (1), 1-7. doi: 10.1007/s10689-017-0003-0

GNAS mutations are present in colorectal traditional serrated adenomas, serrated tubulovillous adenomas and serrated adenocarcinomas with adverse prognostic features

Liu, Cheng, Mckeone, Diane M., Walker, Neal I., Bettington, Mark L., Leggett, Barbara A. and Whitehall, Vicki L. J. (2017). GNAS mutations are present in colorectal traditional serrated adenomas, serrated tubulovillous adenomas and serrated adenocarcinomas with adverse prognostic features. Histopathology, 70 (7), 1079-1088. doi: 10.1111/his.13180

Whole-genome landscape of pancreatic neuroendocrine tumours

Scarpa, Aldo, Chang, David K., Nones, Katia, Corbo, Vincenzo, Patch, Ann-Marie, Bailey, Peter, Lawlor, Rita T., Johns, Amber L., Miller, David K., Mafficini, Andrea, Rusev, Borislav, Scardoni, Maria, Antonello, Davide, Barbi, Stefano, Sikora, Katarzyna O., Cingarlini, Sara, Vicentini, Caterina, McKay, Skye, Quinn, Michael C.J., Bruxner, Timothy J.C., Christ, Angelika N., Harliwong, Ivon, Idrisoglu, Senel, McLean, Suzanne, Nourse, Craig, Nourbakhsh, Ehsan, Wilson, Peter J., Anderson, Matthew J., Fink, J. Lynn ... Grimmond, Sean M. (2017). Whole-genome landscape of pancreatic neuroendocrine tumours. Nature, 543 (7643), 65-71. doi: 10.1038/nature21063

High prevalence of sessile serrated adenomas in contemporary outpatient colonoscopy practice

Bettington, Mark, Walker, Neal, Rahman, Tony, Vandeleur, Ann, Whitehall, Vicki, Leggett, Barbara and Croese, John (2017). High prevalence of sessile serrated adenomas in contemporary outpatient colonoscopy practice. Internal Medicine Journal, 47 (3), 318-323. doi: 10.1111/imj.13329

Clinicopathological and molecular features of sessile serrated adenomas with dysplasia or carcinoma

Bettington, Mark, Walker, Neal, Rosty, Christophe, Brown, Ian, Clouston, Andrew, McKeone, Diane, Pearson, Sally-Ann, Leggett, Barbara and Whitehall, Vicki (2016). Clinicopathological and molecular features of sessile serrated adenomas with dysplasia or carcinoma. Gut, 66 (1), 97-106. doi: 10.1136/gutjnl-2015-310456

RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis

Bond, Catherine E., McKeone, Diane M., Kalimutho, Murugan, Bettington, Mark L., Pearson, Sally-Ann, Dumenil, Troy D., Wockner, Leesa F., Burge, Matthew, Leggett, Barbara A. and Whitehall, Vicki L. J. (2016). RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis. Oncotarget, 7 (43), 70589-70600. doi: 10.18632/oncotarget.12130

Serrated tubulovillous adenoma of the large intestine

Bettington, Mark, Walker, Neal, Rosty, Christophe, Brown, Ian, Clouston, Andrew, Mckeone, Diane, Pearson, Sally-Ann, Klein, Kerenaftali, Leggett, Barbara and Whitehall, Vicki (2016). Serrated tubulovillous adenoma of the large intestine. Histopathology, 68 (4), 578-587. doi: 10.1111/his.12788

Aspirin, Ibuprofen, and the Risk for Colorectal Cancer in Lynch Syndrome

Ouakrim, Driss Ait, Dashti, Seyedeh Ghazaleh, Chau, Rowena, Buchanan, Daniel D., Clendenning, Mark, Rosty, Christophe, Winship, Ingrid M., Young, Joanne P., Giles, Graham G., Leggett, Barbara, Macrae, Finlay A., Ahnen, Dennis J., Casey, Graham, Gallinger, Steven, Haile, Robert W., Le Marchand, Loic, Thibodeau, Stephen N., Lindor, Noralane M., Newcomb, Polly A., Potter, John D., Baron, John A., Hopper, John L., Jenkins, Mark A. and Win, Aung Ko (2015). Aspirin, Ibuprofen, and the Risk for Colorectal Cancer in Lynch Syndrome. Journal of the National Cancer Institute, 107 (9) djv170. doi: 10.1093/jnci/djv170

A clinicopathological and molecular analysis of 200 traditional serrated adenomas

Bettington, Mark L., Walker, Neal I., Rosty, Christophe, Brown, Ian S., Clouston, Andrew D., McKeone, Diane M., Pearson, Sally Ann, Klein, Kerenaftali, Leggett, Barbara A. and Whitehall, Vicki L. (2015). A clinicopathological and molecular analysis of 200 traditional serrated adenomas. Modern Pathology, 28 (3), 414-427. doi: 10.1038/modpathol.2014.122

Methylation and expression of the tumour suppressor, PRDM5, in colorectal cancer and polyp subgroups

Bond, Catherine E., Bettington, Mark L., Pearson, Sally-Ann, McKeone, Diane M., Leggett, Barbara A. and Whitehall, Vicki (2015). Methylation and expression of the tumour suppressor, PRDM5, in colorectal cancer and polyp subgroups. BMC Cancer, 15 (1) 20, 20. doi: 10.1186/s12885-015-1011-9

Colorectal cancer screening

Leggett, B.A. and Hewett, D.G. (2015). Colorectal cancer screening. Internal Medicine Journal, 45 (1), 6-15. doi: 10.1111/imj.12636

Remoteness, race and social disadvantage: Disparities in hepatocellular carcinoma incidence and survival in Queensland, Australia

Clark, Paul J., Stuart, Katherine A., Leggett, Barbara A., Crawford, Darrell H., Boyd, Peter, Fawcett, Jonathan, Whiteman, David C. and Baade, Peter D. (2015). Remoteness, race and social disadvantage: Disparities in hepatocellular carcinoma incidence and survival in Queensland, Australia. Liver International, 35 (12), 2584-2594. doi: 10.1111/liv.12853

Isocitrate dehydrogenase 1 R132C mutation occurs exclusively in microsatellite stable colorectal cancers with the CpG island methylator phenotype

Whitehall, V. L. J., Dumenil, T. D., McKeone, D. M., Bond, C. E., Bettington, M. L., Buttenshaw, R. L., Bowdler, L., Montgomery, G. W., Wockner, L. F. and Leggett, B. A. (2014). Isocitrate dehydrogenase 1 R132C mutation occurs exclusively in microsatellite stable colorectal cancers with the CpG island methylator phenotype. Epigenetics, 9 (11), 1454-1460. doi: 10.4161/15592294.2014.971624

Genome-wide DNA methylation analysis of formalin-fixed paraffin embedded colorectal cancer tissue

Dumenil, Troy D., Wockner, Leesa F., Bettington, Mark, Mckeone, Diane M., Klein, Kerenaftali, Bowdler, Lisa M., Montgomery, Grant W., Leggett, Barbara A. and Whitehall, Vicki L. J. (2014). Genome-wide DNA methylation analysis of formalin-fixed paraffin embedded colorectal cancer tissue. Genes Chromosomes and Cancer, 53 (7), 537-548. doi: 10.1002/gcc.22164

The CIMP phenotype in BRAF mutant serrated polyps from a prospective colonoscopy patient cohort

Fernando, Winnie C., Miranda, Mariska S., Worthley, Daniel L., Togashi, Kazutomo, Watters, Dianne J., Leggett, Barbara A. and Spring, Kevin J. (2014). The CIMP phenotype in BRAF mutant serrated polyps from a prospective colonoscopy patient cohort. Gastroenterology Research and Practice, 2014 (8) 374926, 1084-1091. doi: 10.1155/2014/374926

Microsatellite stable colorectal cancers stratified by the BRAF V600E mutation show distinct patterns of chromosomal instability

Bond, Catherine E., Nancarrow, Derek J., Wockner, Leesa F., Wallace, Leanne, Montgomery, Grant W., Leggett, Barbara A. and Whitehall, Vicki L. J. (2014). Microsatellite stable colorectal cancers stratified by the BRAF V600E mutation show distinct patterns of chromosomal instability. Plos One, 9 (3) e91739, e91739. doi: 10.1371/journal.pone.0091739

Copper removal strategies for Wilson's disease crisis in the ICU

Reynolds, H. V., Talekar, C. R., Bellapart, J., Leggett, B. A. and Boots, R. J. (2014). Copper removal strategies for Wilson's disease crisis in the ICU. Anaesthesia and Intensive Care, 42 (2), 253-257.

Prevalence of serrated polyps: implications for significance as colorectal cancer precursors

Tutticci, Nicholas J., Hewett, David G. and Leggett, Barbara A. (2013). Prevalence of serrated polyps: implications for significance as colorectal cancer precursors. Colorectal Cancer, 2 (6), 535-547. doi: 10.2217/CRC.13.70

PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in Colorectal cancer

Day, Fiona L., Jorissen, Robert N., Lipton, Lara, Mouradov, Dmitri, Sakthianandeswaren, Anuratha, Christie, Michael, Li, Shan, Tsui, Cary, Tie, Jeannie, Desai, Jayesh, Xu, Zheng-Zhou, Molloy, Peter, Whitehall, Vicki, Leggett, Barbara A., Jones, Ian T., McLaughlin, Stephen, Ward, Robyn L., Hawkins, Nicholas J., Ruszkiewicz, Andrew R., Moore, James, Busam, Dana, Zhao, Qi, Strausberg, Robert L., Gibbs, Peter and Sieber, Oliver M. (2013). PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in Colorectal cancer. Clinical Cancer Research, 19 (12), 3285-3296. doi: 10.1158/1078-0432.CCR-12-3614

Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management

Rosty, Christophe, Hewett, David G., Brown, Ian S., Leggett, Barbara A. and Whitehall, Vicki L. J. (2013). Serrated polyps of the large intestine: current understanding of diagnosis, pathogenesis, and clinical management. Journal of Gastroenterology, 48 (3), 287-302. doi: 10.1007/s00535-012-0720-y

Risks of colorectal and other cancers after endometrial cancer for women with Lynch syndrome

Win, Aung Ko, Lindor, Noralane M., Winship, Ingrid, Tucker, Katherine M., Buchanan, Daniel D., Young, Joanne P., Rosty, Christophe, Leggett, Barbara, Giles, Graham G., Goldblatt, Jack, Macrae, Finlay A., Parry, Susan, Kalady, Matthew F., Baron, John A., Ahnen, Dennis J., Le Marchand, Loic, Gallinger, Steven, Haile, Robert W., Newcomb, Polly A., Hopper, John L. and Jenkins, Mark A. (2013). Risks of colorectal and other cancers after endometrial cancer for women with Lynch syndrome. Journal of the National Cancer Institute, 105 (4), 274-279. doi: 10.1093/jnci/djs525

The serrated pathway to colorectal carcinoma: current concepts and challenges

Bettington, Mark, Walker, Neal, Clouston, Andrew, Brown, Ian, Leggett, Barbara and Whitehall, Vicki (2013). The serrated pathway to colorectal carcinoma: current concepts and challenges. Histopathology, 62 (3), 367-386. doi: 10.1111/his.12055

Chromosomal instability in BRAF mutant, microsatellite stable colorectal cancers

Bond, Catherine E., Umapathy, Aarti, Buttenshaw, Ron L., Wockner, Leesa, Leggett, Barbara A. and Whitehall, Vicki L. J. (2012). Chromosomal instability in BRAF mutant, microsatellite stable colorectal cancers. Plos One, 7 (10) e47483, e47483.1-e47483.9. doi: 10.1371/journal.pone.0047483

Risks of primary extracolonic cancers following colorectal cancer in lynch syndrome

Win, Aung Ko, Lindor, Noralane M., Young, Joanne P., Macrae, Finlay A., Young, Graeme P., Williamson, Elizabeth, Parry, Susan, Goldblatt, Jack, Lipton, Lara, Winship, Ingrid, Leggett, Barbara, Tucker, Katherine M., Giles, Graham G., Buchanan, Daniel D., Clendenning, Mark, Rosty, Christophe, Arnold, Julie, Levine, A. Joan, Haile, Robert W., Gallinger, Steven, Le Marchand, Loic, Newcomb, Polly A., Hopper, John L. and Jenkins, Mark A. (2012). Risks of primary extracolonic cancers following colorectal cancer in lynch syndrome. Journal of the National Cancer Institute, 104 (18), 1363-1372. doi: 10.1093/jnci/djs351

Oncogenic PIK3CA mutations in colorectal cancers and polyps

Whitehall, Vicki L. J., Rickman, Celestine, Bond, Catherine E., Ramsnes, Ingunn, Greco, Sonia A., Umapathy, Aarti, McKeone, Diane, Faleiro, Rebecca J., Buttenshaw, Ron L., Worthley, Daniel L., Nayler, Sam, Zhao, Zhen Zhen, Montgomery, Grant W., Mallitt, Kylie-Ann, Jass, Jeremy R., Matsubara, Nagahide, Notohara, Kenji, Ishii, Tatsuhiro and Leggett, Barbara A. (2012). Oncogenic PIK3CA mutations in colorectal cancers and polyps. International Journal of Cancer, 131 (4), 813-820. doi: 10.1002/ijc.26440

Microsatellite instability: Detection and management in sporadic colorectal cancer

Whitehall, Vicki and Leggett, Barbara (2011). Microsatellite instability: Detection and management in sporadic colorectal cancer. Journal of Gastroenterology and Hepatology, 26 (12), 1697-1699. doi: 10.1111/j.1440-1746.2011.06932.x

Determining the frequency of de novo germline mutations in DNA mismatch repair genes

Win, Aung Ko, Jenkins, Mark A., Buchanan, Daniel D., Clendenning, Mark, Young, Joanne P., Giles, Graham G., Goldblatt, Jack, Leggett, Barbara A., Hopper, John L., Thibodeau, Stephen N. and Lindor, Noralane M. (2011). Determining the frequency of de novo germline mutations in DNA mismatch repair genes. Journal of Medical Genetics, 48 (8), 530-534. doi: 10.1136/jmedgenet-2011-100082

Metachronous colorectal cancer risk for mismatch repair gene mutation carriers: The advantage of more extensive colon surgery

Parry, Susan, Win, Aung Ko, Parry, Bryan, Macrae, Finlay A., Gurrin, Lyle C., Church, James M., Baron, John A., Giles, Graham G., Leggett, Barbara A., Winship, Ingrid, Lipton, Lara, Young, Graeme P., Young, Joanne P., Lodge, Caroline J., Southey, Melissa C., Newcomb, Polly A., Le Marchand, Loic, Haile, Robert W., Lindor, Noralane M., Gallinger, Steven, Hopper, John L. and Jenkins, Mark A. (2011). Metachronous colorectal cancer risk for mismatch repair gene mutation carriers: The advantage of more extensive colon surgery. Gut, 60 (7), 950-957. doi: 10.1136/gut.2010.228056

Numerical ecology validates a biogeographical distribution and gender-based effect on mucosa-associated bacteria along the human colon

de Carcer, Daniel Aguirre, Ó Cuív, Páraic, Wang, Tingting, Kang, Seungha, Worthley, Daniel, Whitehall, Vicki, Gordon, Iain, McSweeney, Chris, Leggett, Barbara and Morrison, Mark (2011). Numerical ecology validates a biogeographical distribution and gender-based effect on mucosa-associated bacteria along the human colon. ISME Journal, 5 (5), 801-809. doi: 10.1038/ismej.2010.177

The effects from DNA extraction methods on the evaluation of microbial diversity associated with human colonic tissue

Ó Cuív, Páraic, de Carcer, Daniel Aguirre, Jones, Michelle, Klaassens, Eline S., Worthley, Daniel L., Whitehall, Vicki L. J., Kang, Seungha, McSweeney, Christopher S., Leggett, Barbara A. and Morrison, Mark (2011). The effects from DNA extraction methods on the evaluation of microbial diversity associated with human colonic tissue. Microbial Ecology, 61 (2), 353-362. doi: 10.1007/s00248-010-9771-x

Tubular adenomas with minor villous changes show molecular features characteristic of tubulovillous adenomas

Ishii, Tatsushiro, Notohara, Kenji, Umapathy, Aarti, Mallitt, Kylie-Ann, Chikuba, Hiroshi, Moritani, Yukitoshi, Tanaka, Noriaki, Rosty, Christophe, Matsubara, Nagahide, Jass, Jeremy, Leggett, Barbara and Whitehall, Vicki (2011). Tubular adenomas with minor villous changes show molecular features characteristic of tubulovillous adenomas. American Journal of Surgical Pathology, 35 (2), 212-220. doi: 10.1097/PAS.0b013e318205df20

p53 mutation is common in microsatellite stable, BRAF mutant colorectal cancers

Bond, Catherine E., Umapathy, Aarti, Ramsnes, Ingunn, Greco, Sonia A., Zhao, Zhen Zhen, Mallitt, Kylie-Ann, Buttenshaw, Ron L., Montgomery, Grant W., Leggett, Barbara A. and Whitehall, Vicki L.J. (2011). p53 mutation is common in microsatellite stable, BRAF mutant colorectal cancers. International Journal of Cancer, 130 (7), 1567-1576. doi: 10.1002/ijc.26175

Repeat participation in colorectal cancer screening utilizing fecal occult blood testing: A community-based project in a rural setting

Janda, Monika, Hughes, Karen L., Auster, Josephine F., Leggett, Barbara A. and Newman, Beth M. (2010). Repeat participation in colorectal cancer screening utilizing fecal occult blood testing: A community-based project in a rural setting. Journal of Gastroenterology and Hepatology, 25 (10), 1661-1667. doi: 10.1111/j.1440-1746.2010.06405.x

Hyperplastic Polyposis syndrome is associated with cigarette smoking, which may be a modifiable risk factor

Walker, R. Griff, Landmann, Juergen K., Hewett, David G., Worthley, Daniel L., Buttenshaw, Ron L., Knight, Ngaire, Webb, Penny M., Whiteman, David C., Whitehall, Vicki L. and Leggett, Barbara A. (2010). Hyperplastic Polyposis syndrome is associated with cigarette smoking, which may be a modifiable risk factor. The American Journal of Gastroenterology, 105 (7), 1642-1647. doi: 10.1038/ajg.2009.757

Re: Protection from right-and left-sided colorectal neoplasms after colonoscopy: Population-based study

Worthley, Daniel L., Hewett, David G., Spring, Kevin J., Whitehall, Vicki L. J. and Leggett, Barbara A. (2010). Re: Protection from right-and left-sided colorectal neoplasms after colonoscopy: Population-based study. Journal of the National Cancer Institute, 102 (13), 990-990. doi: 10.1093/jnci/djq189

Role of the serrated pathway in colorectal cancer pathogenesis

Leggett, Barbara and Whitehall, Vicki (2010). Role of the serrated pathway in colorectal cancer pathogenesis. Gastroenterology, 138 (6), 2088-2100. doi: 10.1053/j.gastro.2009.12.066

Analysis of the Association between CIMP and BRAF(V600E) in Colorectal Cancer by DNA Methylation Profiling

Hinoue, Toshinori, Weisenberger, Daniel J., Pan, Fei, Campan, Mihaela, Kim, Myungjin, Young, Joanne, Whitehall, Vicki L., Leggett, Barbara A. and Laird, Peter W. (2009). Analysis of the Association between CIMP and BRAF(V600E) in Colorectal Cancer by DNA Methylation Profiling. PLoS One, 4 (12) e8357, e8357. doi: 10.1371/journal.pone.0008357

Intergroup communication between hospital doctors: Implications for quality of patient care

Hewett, David G., Watson, Bernadette M., Gallois, Cindy, Ward, Michael and Leggett, Barbara A. (2009). Intergroup communication between hospital doctors: Implications for quality of patient care. Social Science and Medicine, 69 (12), 1732-1740. doi: 10.1016/j.socscimed.2009.09.048

Varying etiologies lead to different molecular changes in Australian and South African hepatocellular carcinomas

Herath, Nirmitha I., Purdie, David M., Kew, Michael C., Smith, Jeffery L., Young, Joanne, Leggett, Barbara A. and Macdonald, Graeme A. (2009). Varying etiologies lead to different molecular changes in Australian and South African hepatocellular carcinomas. International Journal of Oncology, 35 (5), 1081-1089. doi: 10.3892/ijo_00000423

HLA-DR expression is associated with better prognosis in sporadic Australian clinicopathological Stage C colorectal cancers

Walsh, Michael D., Dent, Owen F., Young, Joanne P., Wright, Caroline M., Barker, Melissa A., Leggett, Barbara A., Bokey, Les, Chapuis, Pierre H., Jass, Jeremy R. and Macdonald, Graeme A. (2009). HLA-DR expression is associated with better prognosis in sporadic Australian clinicopathological Stage C colorectal cancers. International Journal of Cancer, 125 (5), 1231-1237. doi: 10.1002/ijc.24484

Communication in medical records : Intergroup language and patient care

Hewett, DG, Watson, BM, Gallois, C, Ward, M and Leggett, BA (2009). Communication in medical records : Intergroup language and patient care. Journal of Language and Social Psychology, 28 (2), 119-138. doi: 10.1177/0261927X08330612

The use of indigocarmine spray increases the colonoscopic detection rate of adenomas

Togashi, Kazutomo, Hewett, David, Radford-Smith, Graham, Francis, Leo, Leggett, Barbara A. and Appleyard, Mark N. (2009). The use of indigocarmine spray increases the colonoscopic detection rate of adenomas. Journal of Gastroenterology, 44 (8), 826-833. doi: 10.1007/s00535-009-0065-3

Epigenetic silencing of EphA1 expression in colorectal cancer is correlated with poor survival

Herath, N. I., Doecke, J., Spanevello, M. D., Leggett, B. A. and Boyd, A. W. (2009). Epigenetic silencing of EphA1 expression in colorectal cancer is correlated with poor survival. British Journal of Cancer, 100 (7), 1095-1102. doi: 10.1038/sj.bjc.6604970

Stoma surgery for colorectal cancer: A population-based study of patient concerns

Lynch, B.M., Hawkes, A.L., Steginga, S.K., Leggett, B. A. and Aitken, J. F. (2008). Stoma surgery for colorectal cancer: A population-based study of patient concerns. Journal Of Wound Ostomy And Continence Nursing, 35 (4), 424-428. doi: 10.1097/01.WON.0000326664.78131.1c

Bone morphogenic protein 3 inactivation is an early and frequent event in colorectal cancer development

Loh, K, Chia, J. A., Greco, S., Cozzi, S.J., Buttenshaw, R.L., Bond, C.E., Simms, L.A., Pike, T., Young, J. P., Jass, J.R., Spring, K. J., Leggett, B. A. and Whitehall, V.L.J. (2008). Bone morphogenic protein 3 inactivation is an early and frequent event in colorectal cancer development. Genes, Chromosomes & Cancer, 47 (6), 449-460. doi: 10.1002/gcc.20552

Self-reported information on the diagnosis of colorectal cancer was reliable but not necessarily valid

Lynch Brigid M., Youlden, Danny, Fritschi, Lin, Newman, Beth, Pakenham, Kenneth I., Leggett, Barbara, Owen, Neville and Aitken, Joanne F. (2008). Self-reported information on the diagnosis of colorectal cancer was reliable but not necessarily valid. Journal of Clinical Epidemiology, 61 (5), 498-504. doi: 10.1016/j.jclinepi.2007.05.018

Molecular, pathologic, and clinical features of early-onset endometrial cancer: Identifying presumptive Lynch Syndrome patients

Walsh, M. D., Cummings, M. C., Buchanan, D. D., Dambacher, W. M., Arnold, S., McKeone, D., Byrnes, R., Barker, M. A., Leggett, B. A., Gattas, M., Jass, J. R., Spurdle, A. B., Young, J. and Obermair, A. (2008). Molecular, pathologic, and clinical features of early-onset endometrial cancer: Identifying presumptive Lynch Syndrome patients. Clinical Cancer Research, 14 (6), 1692-1700. doi: 10.1158/1078-0432.CCR-07-1849

Colorectal carcinogenesis: Road maps to cancer

Worthley, D. L., Whitehall, V. L., Spring, K. J. and Leggett. B. A. (2007). Colorectal carcinogenesis: Road maps to cancer. World Journal of Gastroenterology, 13 (28), 3784-3791.

Promoter methylation of the mutated in colorectal cancer gene is a frequent early event in colorectal cancer

Kohonen-Corish, M. R. J., Sigglekow, N. D., Susanto, J., Chapuis, P. H., Bokey, E. L., Dent, O. F., Chan, C., Lin, B. P. C., Seng, T. J., Laird, P. W., Young, J., Leggett, B. A., Jass, J. R. and Sutherland, R. L. (2007). Promoter methylation of the mutated in colorectal cancer gene is a frequent early event in colorectal cancer. Oncogenomics, 26 (30), 4435-4441. doi: 10.1038/sj.onc.1210210

The MUC13 cell surface mucin is highly expressed by human colorectal carcinomas

Walsh, Michael D., Young, Joanne P., Leggett, Barbara A., Williams, Stephanie H., Jass, Jeremy R. and McGuckin, Michael A. (2007). The MUC13 cell surface mucin is highly expressed by human colorectal carcinomas. Human Pathology, 38 (6), 883-892. doi: 10.1016/j.humpath.2006.11.020

Modes of presentation and pathways to diagnosis of colorectal cancer in Queensland

Lynch, B. M., Baade, P., Fritschi, L., Leggett, B., Owen, N., Pakenham, K., Newman, B. and Aitken, J. F. (2007). Modes of presentation and pathways to diagnosis of colorectal cancer in Queensland. Medical Journal of Australia, 186 (6), 288-291. doi: 10.5694/j.1326-5377.2007.tb00902.x

Silencing of O-6-methylguanine DNA methyltransferase in the absence of promoter hypermethylation in hepatocellular carcinomas from Australia and South Africa

Herath, Nirmitha I., Walsh, Michael D., Kew, Michael, Smith, Jeffery L., Jass, Jeremy R., Young, Joanne, Leggett, Barbara A. and Macdonald, Graeme A. (2007). Silencing of O-6-methylguanine DNA methyltransferase in the absence of promoter hypermethylation in hepatocellular carcinomas from Australia and South Africa. Oncology Reports, 17 (4), 817-822. doi: 10.3892/or.17.4.817

SnoN expression is differently regulated in microsatellite unstable compared with microsatellite stable colorectal cancers

Chia, June A., Simms, Lisa A., Cozzi, Sarah-Jane, Young, Joanne, Jass, Jeremy R., Walsh, Michael D., Spring, Kevin J., Leggett, Barbara A. and Whitehall, Vicki L. J. (2006). SnoN expression is differently regulated in microsatellite unstable compared with microsatellite stable colorectal cancers. BMC Cancer, 6 (252) 252, 1-6. doi: 10.1186/1471-2407-6-252

High prevalence of sessile serrated adenomas with BRAF mutations: A prospective study of patients undergoing colonoscopy

Spring, Kevin, Zhao, Zhen Zhen, Karamatic, Rozemary, Walsh, Michael, Whitehall, Vicki, Pike, Tanya, Simms, Lisa, Young, Joanne, James, Michael, Montgomery, Grant, Appleyard, Mark, Hewett, David, Togashi, Kazutomo, Jass, Jeremy and Leggett, Barbara (2006). High prevalence of sessile serrated adenomas with BRAF mutations: A prospective study of patients undergoing colonoscopy. Gastroenterology, 131 (5), 1400-1407. doi: 10.1053/j.gastro.2006.08.038

Hyperplastic polyposis syndrome: Phenotypic presentations and the role of MBD4 and MYH

Chow, Elizabeth, Lipton, Lara, Lynch, Elly, D’Souza, Rebecca, Aragona, Clelia, Hodgkin, Lindy, Brown, Gregor, Winship, Ingrid, Barker, Melissa, Buchanan, Daniel, Cowie, Shannon, Nasioulas, Steve, du Sart, Desiree, Young, Joanne, Leggett, Barbara, Jass, Jeremy and Macrae, Finlay (2006). Hyperplastic polyposis syndrome: Phenotypic presentations and the role of MBD4 and MYH. Gastroenterology, 131 (1), 30-39. doi: 10.1053/j.gastro.2006.03.046

DNA methylation patterns in adenomas from FAP, multiple adenoma and sporadic colorectal carcinoma patients

Wynter, Coral V. A., Kambara, Takeshi, Walsh, Michael D., Leggett, Barbara A., Young, Joanne and Jass, Jeremy R. (2006). DNA methylation patterns in adenomas from FAP, multiple adenoma and sporadic colorectal carcinoma patients. International Journal of Cancer, 118 (4), 907-915. doi: 10.1002/ijc.21363

Germline epimutations of APC are not associated with inherited colorectal polyposis

Hitchins, M, Suter, C, Wong, J, Cheong, K, Hawkins, N, Leggett, B, Scott, R, Spigelman, A, Tomlinson, I, Martin, D and Ward, R (2006). Germline epimutations of APC are not associated with inherited colorectal polyposis. Gut, 55 (4), 586-587. doi: 10.1136/gut.2005.087486

Reliability of a measure of prediagnosis physical activity for cancer survivors

Lynch, Brigid M., Owen, Neville, Newman, Beth, Pakenham, Ken, Leggett, Barbara, Dunn, Jeff and Aitken, Joanne F. (2006). Reliability of a measure of prediagnosis physical activity for cancer survivors. Medicine and Science in Sports and Exercise, 38 (4), 715-719. doi: 10.1249/01.mss.0000210196.94952.8b

The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b

Simpson, Fiona, Lammerts van Bueren, Kelly L., Butterfield, Natalie, Bennetts, Jennifer S., Bowles, Josephine, Adolphe, Christelle, Simms, Lisa A., Young, Joanne, Walsh, Michael D., Leggett, Barbara, Fowles, Lindsay F. and Wicking, Carol (2006). The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b. Experimental Cell Research, 312 (1), 73-85. doi: 10.1016/j.yexcr.2005.09.020

Guaiac versus immunochemical tests: Faecal occult blood test screening for colorectal cancer in a rural community

Hughes, Karen, Leggett, Barbara, Del Mar, Christopher, Croese, John, Fairley, Stephen, Masson, John, Aitken, Joanne, Clavarino, Alexandra, Janda, Monika, Stanton, Warren R., Tong, Shilu and Newman, Beth (2005). Guaiac versus immunochemical tests: Faecal occult blood test screening for colorectal cancer in a rural community. Australian And New Zealand Journal Of Public Health, 29 (4), 358-364. doi: 10.1111/j.1467-842X.2005.tb00207.x

Evidence for BRAF mutation and variable levels of microsatellite instability in a syndrome of familial colorectal cancer

Young, Joanne, Simms, Lisa A., Barker, Melissa A., Walsh, Michael D., Biden, Kelli G., Buttenshaw, Ron, Whitehall, Vicki L.J., Arnold, Sven, Jackson, Leigh, Kambara, Takeshi, Spring, Kevin J., Jenkins, Mark A., Walker, Graeme J., Hopper, John L., Leggett, Barbara A. and Jass, Jeremy R. (2005). Evidence for BRAF mutation and variable levels of microsatellite instability in a syndrome of familial colorectal cancer. Clinical Gastroenterology and Hepatology, 3 (3), 254-263. doi: 10.1016/S1542-3565(04)00673-1

The view from two sides: A qualitative study of community and medical perspectives on screening for colorectal cancer using FOBT

Clavarino, AM, Janda, M, Hughes, KL, Del Mar, C, Tong, SL, Stanton, WR, Aitken, JF, Leggett, BA and Newman, B (2004). The view from two sides: A qualitative study of community and medical perspectives on screening for colorectal cancer using FOBT. Preventive Medicine, 39 (3), 482-490. doi: 10.1016/j.ypmed.2004.05.015

Role of inherited defects of MYH in the development of sporadic colorectal cancer

Kambara, Takeshi, Whitehall, Vicki L. J., Spring, Kevin J., Barker, Melissa A., Arnold, Sven, Wynter, Coral V. A., Matsubara, Nagahide, Tanaka, Noriaki, Young, Joanne P., Leggett, Barbara A. and Jass, Jeremy R. (2004). Role of inherited defects of MYH in the development of sporadic colorectal cancer. Genes, Chromosomes and Cancer, 40 (1), 1-9. doi: 10.1002/gcc.20011

Quality of Life and Colorectal Cancer: a Review

Dunn, Jeff, Lynch, Brigid, Aitken, Joanne, Leggett, Barbara, Pakenham, Kenneth and Newman, Beth (2003). Quality of Life and Colorectal Cancer: a Review. Australian And New Zealand Journal of Public Health, 27 (1), 41-53. doi: 10.1111/j.1467-842X.2003.tb00378.x

Knowledge, attitude and intentions related to colorectal cancer screening using faecal occult blood tests in a rural Australian population

Janda, Monika, Stanton, Warren R., Hughes, Karen, Del Mar, Christopher, Clavarino, Alexandra, Aitken, Joanne F., Tong, Shilu, Short, Leonie, Leggett, Barbara and Newman, Beth (2003). Knowledge, attitude and intentions related to colorectal cancer screening using faecal occult blood tests in a rural Australian population. Asia-Pacific Journal of Public Health, 15 (1), 50-56. doi: 10.1177/101053950301500109

A case of myoepithelial carcinoma displaying biallelic inactivation of the tumour suppressor gene APC in a patient with familial adenomatous polyposis

Young, J., Barker, M., Robertson, T., Nasioulas, S., Tannenberg, A., Buttenshaw, R. L., Knight, N., Jass, J. R. and Leggett, B. A. (2002). A case of myoepithelial carcinoma displaying biallelic inactivation of the tumour suppressor gene APC in a patient with familial adenomatous polyposis. Journal of Clinical Pathology, 55 (3), 230-232. doi: 10.1136/jcp.55.3.230

Faecal occult blood test: Current practice in a rural Queensland community

Janda, Monika, Hughes, Karen, Tong, Shilu, Stanton, Warren R., Aitken, Joanne, Clavarino, Alexandra, Short, Leonie, Del Mar, Christopher, Leggett, Barbara and Newman, Beth (2002). Faecal occult blood test: Current practice in a rural Queensland community. Australian Journal of Rural Health, 10 (1), 57-64. doi: 10.1111/j.1440-1584.2002.tb00010.x

Mutation searching in colorectal cancer studies: Experience with a denaturing high-pressure liquid chromatography system for exon-by-exon scanning of tumour suppressor genes

Young, Joanne, Barker, Melissa, Fraser, Leigh, Walsh, Michael D., Spring, Kevin, Biden, Kelli G., Hopper, John L., Leggett, Barbara A. and Jass, Jeremy R. (2002). Mutation searching in colorectal cancer studies: Experience with a denaturing high-pressure liquid chromatography system for exon-by-exon scanning of tumour suppressor genes. Pathology, 34 (6), 529-533. doi: 10.1080/0031302021000035965-1

Proliferation, apoptosis, and survival in high-level microsatellite instability sporadic colorectal cancer

Michael-Robinson, J. M., Reid, L. E., Purdie, D. M., Biemer-Huttmann, A. E., Walsh, M. D., Pandeya, N., Simms, L. A., Young, J. P., Leggett, B. A., Jass, J. R. and Radford-Smith, G. L. (2001). Proliferation, apoptosis, and survival in high-level microsatellite instability sporadic colorectal cancer. Clinical Cancer Research, 7 (8), 2347-2356.

HPP1: A transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers

Young, J. P., Biden, K. G., Simms, L. A., Huggard, P. R., Karamatic, R., Eyre, H. J., Sutherland, G. R., Herath, N. I., Barker, M. A., Anderson, G. J., Fitzpatrick, D. R., Ramm, G. A., Jass, J. R. and Leggett, B. A. (2001). HPP1: A transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers. Proceedings of the National Academy of Sciences of the United States of America, 98 (1), 265-270. doi: 10.1073/pnas.011415298

Hyperplastic polyps and DNA microsatellite unstable cancers of the colorectum

Jass, J. R., Young, J. and Leggett, B. A. (2000). Hyperplastic polyps and DNA microsatellite unstable cancers of the colorectum. Histopathology, 37 (4), 295-301. doi: 10.1046/j.1365-2559.2000.01028.x

Adenocarcinoma of colon differentiating as dome epithelium of gut-associated lymphoid tissue

Jass, J. R., Constable, L., Sutherland, R., Winterford, CM, Walsh, M., Young, J. P. and Leggett, B. A. (2000). Adenocarcinoma of colon differentiating as dome epithelium of gut-associated lymphoid tissue. Histopathology, 36 (2), 116-120. doi: 10.1046/j.1365-2559.2000.00864.x

DNA microsatellite instability and mismatch repair protein loss in adenomas presenting in hereditary non-polyposis colorectal cancer

Iino, H., Simms, L., Young, J. P., Arnold, J., Winship, I. M., Webb, S. I., Furlong, K. L., Leggett, B. A. and Jass, J. R. (2000). DNA microsatellite instability and mismatch repair protein loss in adenomas presenting in hereditary non-polyposis colorectal cancer. Gut, 47 (1), 37-42. doi: 10.1136/gut.47.1.37

Mucin core protein expression in colorectal cancers with high levels of microsatellite instability indicates a novel pathway of morphogenesis

Biemer-Huttmann, A. E., Walsh, M. D., McGuckin, M. A., Simms, L. A., Young, J., Leggett, B. A. and Jass, J. R. (2000). Mucin core protein expression in colorectal cancers with high levels of microsatellite instability indicates a novel pathway of morphogenesis. Clinical Cancer Research, 6 (5), 1909-1916.

Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum

Jass, J. R., Iino, H., Ruszkiewicz, A., Painter, D., Solomon, M. J., Koorey, D. J., Cohn, D., Furlong, K. L., Walsh, M. D., Palazzo, J., Edmonston, T. B., Fishel, R., Young, J. P. and Leggett, B. A. (2000). Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of the colorectum. Gut, 47 (1), 43-49. doi: 10.1136/gut.47.1.43

The apoptotic regulatory gene, BCL10, is mutated in sporadic mismatch repair deficient colorectal cancers

Simms, L. A., Young, J., Wicking, C., Meltzer, S. J., Jass, J. R. and Leggett, B. A. (2000). The apoptotic regulatory gene, BCL10, is mutated in sporadic mismatch repair deficient colorectal cancers. Cell Death & Differentiation, 7 (2), 236-237. doi: 10.1038/sj.cdd.4400650

Characterisation of a subtype of colorectal cancer combining features of the suppressor and mild mutator pathways

Jass, J. R., Biden, K. G., Cummings, M. C., Simms, L. A., Walsh, M., Schoch, E., Metlzer, S. J., Wright, C., Searle, J., Young, J. and Leggett, B. A. (1999). Characterisation of a subtype of colorectal cancer combining features of the suppressor and mild mutator pathways. Journal of Clinical Pathology, 52 (6), 455-460. doi: 10.1136/jcp.52.6.455

Expression of Bcl-2 protein is decreased in colorectal adenocarcinomas with microsatellite instability

Biden, Kelli G., Simms, Lisa A., Cummings, Margaret, Buttenshaw, Ron, Schoch, Estelle, Searle, Jeffrey, Gobe, Glenda, Jass, Jeremy R., Meltzer, Stephen J., Leggett, Barbara A. and Young, Joanne (1999). Expression of Bcl-2 protein is decreased in colorectal adenocarcinomas with microsatellite instability. Oncogene, 18 (5), 1245-1249. doi: 10.1038/sj.onc.1202413

Angiogenic factor VEGF is decreased in human colorectal neoplasms showing DNA microsatellite instability

Wynter, C. V. A., Simms, L. A., Buttenshaw, R. L., Biden, K. G., Young, J., Leggett, B. A., Conrad, R. J., Schoch, E. M., Jass, J. R. and Pillay, S. P. (1999). Angiogenic factor VEGF is decreased in human colorectal neoplasms showing DNA microsatellite instability. Journal of Pathology, 189 (3), 319-325. doi: 10.1002/(SICI)1096-9896(199911)189:3<319::AID-PATH436>3.3.CO;2-U

DNA microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyps: a mild mutator pathway for colorectal cancer?

Iino, H., Jass, J. R., Simms, L. A., Young, J., Leggett, B., Ajioka, Y. and Watanabe, H. (1999). DNA microsatellite instability in hyperplastic polyps, serrated adenomas, and mixed polyps: a mild mutator pathway for colorectal cancer?. Journal of Clinical Pathology, 52 (1), 5-9. doi: 10.1136/jcp.52.1.5

Immunohistochemical staining patterms of MUC1, MUC2, MUC4, and MUC5AC mucins in hyperplastic polyps, serrated adenomas, and traditional adenomas of the colorectum

Biemer-Huttmann, A., Walsh, M. D., McGuckin, M. A., Ajioka, Y., Watanabe, H., Leggett, B. A. and Jass, J. R. (1999). Immunohistochemical staining patterms of MUC1, MUC2, MUC4, and MUC5AC mucins in hyperplastic polyps, serrated adenomas, and traditional adenomas of the colorectum. Journal of Histochemistry & Cytochemistry, 47 (8), 1039-1047. doi: 10.1177/002215549904700808

Ultrastructural localisation of epithelial mucin core proteins in colorectal tissue

Winterford, C. M., Walsh, M., Leggett, B. A. and Jass, J. R. (1999). Ultrastructural localisation of epithelial mucin core proteins in colorectal tissue. Journal of Histochemistry & Cytochemistry, 47 (8), 1063-1074. doi: 10.1177/002215549904700811

Reciprocal relationship between the tumor suppressors p53 and BAX in primary colorectal cancers

Simms, Lisa A., Radford-Smith, Graham, Biden, Kelli G., Buttenshaw, Ron, Cummings, Margaret, Jass, Jeremy R., Young, Joanne, Meltzer, Stephen J. and Leggett, Barbara A. (1998). Reciprocal relationship between the tumor suppressors p53 and BAX in primary colorectal cancers. Oncogene, 17 (15), 2003-2008. doi: 10.1038/sj.onc.1202109

CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer

Wicking, C, Simms, LA, Evans, T, Walsh, M, Chawengsaksophak, K, Beck, F, Chenevix-Trench, G, Young, J, Jass, J, Leggett, B and Wainwright, B (1998). CDX2, a human homologue of Drosophila caudal, is mutated in both alleles in a replication error positive colorectal cancer. Oncogene, 17 (5), 657-659. doi: 10.1038/sj.onc.1201971

Morphology of sporadic colorectal cancer with DNA replication errors

Jass, J. R., Do, K. A., Simms, L. A., Iino, H., Wynter, C., Pillay, S. P., Searle, J., Radford-Smith, G., Young, J. and Leggett, B. (1998). Morphology of sporadic colorectal cancer with DNA replication errors. Gut, 42 (5), 673-679. doi: 10.1136/gut.42.5.673

Factors influencing disease expression in hemochromatosis

Crawford, D. H. G., Powell, L. W., Halliday, J. W. and Leggett, B. A. (1996). Factors influencing disease expression in hemochromatosis. Annual Review of Nutrition, 16, 139-160. doi: 10.1146/annurev.nutr.16.1.139

Gastroparesis With Multiple Sclerosis

Read, Stephen J., Leggett, Barbara A. and Pender, Michael P. (1995). Gastroparesis With Multiple Sclerosis. The Lancet, 346 (8984), 1228.

Gastroparesis with multiple sclerosis

Read, Stephen J., Leggett, Barbara A. and Pender, Michael P. (1995). Gastroparesis with multiple sclerosis. Lancet, 346 (8984), 1228-1228. doi: 10.1016/S0140-6736(95)92932-0

Factors affecting the concentrations of ferritin in serum in a healthy Australian population

Leggett, B. A., Brown, N. N., Bryant, S. J., Duplock, L., Powell, L. W. and Halliday, J. W. (1990). Factors affecting the concentrations of ferritin in serum in a healthy Australian population. Clinical Chemistry, 36 (7), 1350-1355. doi: 10.1093/clinchem/36.7.1350

Prevalence of haemochromatosis amongst asymptomatic Australians

Leggett, Barbara A., Halliday, June W., Brown, Nigel N., Bryant, Stewart and Powell, Lawrie W. (1990). Prevalence of haemochromatosis amongst asymptomatic Australians. British Journal of Haematology, 74 (4), 525-530. doi: 10.1111/j.1365-2141.1990.tb06345.x

Clinicopathological Correlates Of Dysplastic Change In Sessile Serrated Lesions

Lamba, Mehul, Ryan, Kimberley, Brown, Ian, Bettington, Mark, Hanigan, Katherine, Gan, Chun H., Grimpen, Florian, Appleyard, Mark and Leggett, Barbara (2021). Clinicopathological Correlates Of Dysplastic Change In Sessile Serrated Lesions. Digestive Disease Week (DDW) 2021, Online, 21-23 May 2021. Philadelphia, PA United States: Elsevier. doi: 10.1016/s0016-5085(21)02134-x

Sessile serrated adenomas with dysplasia: morphological patterns and correlations with MLH1 immunohistochemistry

Liu, C., Walker, N. I., Leggett, B. A., Whitehall, V. L. J., Bettington, M. L. and Rosty, C. (2017). Sessile serrated adenomas with dysplasia: morphological patterns and correlations with MLH1 immunohistochemistry. Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology, Gold Coast, QLD Australia, 20-22 August 2017. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia.

A clinicopathological and molecular analysis of 107 sessile serrated adenomas with dysplasia

Bettington, Mark, Walker, Neal, Rosty, Christophe, Brown, Ian, Clouston, Andrew, Pearson, Sally-Ann, McKeone, Diane, Leggett, Barbara and Whitehall, Vicki (2015). A clinicopathological and molecular analysis of 107 sessile serrated adenomas with dysplasia. 104th Annual Meeting of the United States and Canadian Academy of Pathology, Boston, United States, 21-27 March, 2015. London, United Kingdom: Nature Publishing Group. doi: 10.1038/labinvest.2015.11

Effects of the porcupine inhibitor, LGK974, on RNF43 mutant and wild type colorectal cancer cell lines

Bond, C., Kalimutho, M., Bettington, M., Pearson, S., Leggett, B. and Whitehall, V. (2015). Effects of the porcupine inhibitor, LGK974, on RNF43 mutant and wild type colorectal cancer cell lines. Abstracts of Gastro 2015 GESA‐AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week 2015 | World Congress of Gastroenterology, Brisbane, QLD, Australia, 28 September‐2 October 2015. Richmond, VIC, Australia: John Wiley & Sons.

Wnt and MAPK signalling in colorectal cancer morphology

Fernando, W., Mckeone, D., Bettington, M., Pearson, S., Leggett, B. and Whitehall, V. (2015). Wnt and MAPK signalling in colorectal cancer morphology. Gastro 2015 GESA‐AGW and WGO International Congress, Gastroenterological Society of Australia Australian Gastroenterology Week 2015 | World Congress of Gastroenterology, Brisbane, QLD Australia, 28-September-1 October 2015. HOBOKEN: WILEY-BLACKWELL.

A clinicopathological and molecular appraisal of a large series of traditional serrated adenomas

Bettington, M., Walker, N., Brown, I., Rosty, C., Clouston, A., McKeone, D., Pearson, S-A, Leggett, B. and Whitehall, V. (2014). A clinicopathological and molecular appraisal of a large series of traditional serrated adenomas. 103rd Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP), San Diego, United States, Mar 01-07, 2014. London United Kingdom: Nature Publishing Group. doi: 10.1038/labinvest.2014.22

Changing incidence of BRAF and KRAS mutations in colorectal carcinoma

Bettington, M., Brown, I., Walker, N., Rosty, C., Clouston, A., Pearson, S-A, Mckeone, D., Leggett, B. and Whitehall, V. (2014). Changing incidence of BRAF and KRAS mutations in colorectal carcinoma. Australian Gastroenterology Week 2014, Broadbeach, Australia, 22-24 October 2014. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12736_2

Integrated genome wide DNA methylation and gene expression analysis identifies subgroups of colorectal cancer with distinct molecular and clinical features

Dumenil, T. D., Klein, K., Wockner, L. F., Mckeone, D. M., Bowdler, L. M., Montgomery, G. W., Leggett, B. A. and Whitehall, V. L. J. (2014). Integrated genome wide DNA methylation and gene expression analysis identifies subgroups of colorectal cancer with distinct molecular and clinical features. Australian Gastroenterology Week 2014, Broadbeach, QLD Australia, 22‐24 October 2014. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia.

Methylation and expression of the tumor suppressor, PRDM5, in colorectal cancer subgroups

Bond, C., Bettington, M., Pearson, S., Mckeone, D., Wockner, L., Leggett, B. and Whitehall, V. (2014). Methylation and expression of the tumor suppressor, PRDM5, in colorectal cancer subgroups. Australian Gastroenterology Week 2014, Broadbeach, QLD Australia, 22‐24 October 2014. HOBOKEN: WILEY-BLACKWELL.

Tubulovillous adenoma with prominent architectural serration - a clinicopathological and molecular appraisal of a new subtype of colorectal polyp

Bettington, M., Walker, N., Brown, I., Rosty, C., Clouston, A., Pearson, S-A, Mckeone, D., Leggett, B. and Whitehall, V. (2014). Tubulovillous adenoma with prominent architectural serration - a clinicopathological and molecular appraisal of a new subtype of colorectal polyp. Australian Gastroenterology Week 2014, Broadbeach, Australia, 22-24 October 2014. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12736_2

Wnt signaling in an unselected series of colorectal carcinomas

Bettington, M., Bond, C., Brown, I., Walker, N., Rosty, C., Clouston, A., Pearson, S-A, Mckeone, D., Leggett, B. and Whitehall, V. (2014). Wnt signaling in an unselected series of colorectal carcinomas. Australian Gastroenterology Week 2014, Broadbeach, Australia, 22-24 October 2014. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/jgh.12736_2

The prevalence and predictors of proximal serrated polyps in routine clinical practice: a prospective observational study

Tutticci, Nicholas J., Croese, John, Kanowski, Peter, Skoien, Richard, Leggett, Barbara and Hewett, David G. (2012). The prevalence and predictors of proximal serrated polyps in routine clinical practice: a prospective observational study. Australian Gastroenterology Week 2012, Adelaide, SA, Australia, 16-19 October 2012. Richmond, VIC, Australia: Wiley-Blackwell. doi: 10.1111/j.1440-1746.2011.07251_3.x

Prevalence and variable detection rates of serrated polyps during colonoscopy

Kiel, N. J., Smith, A. J., Leggett, B. A., Appleyard, M. N. and Hewett, D. G. (2011). Prevalence and variable detection rates of serrated polyps during colonoscopy. Australian Gastroenterology Week 2011, Brisbane, Australia, 12-15 September 2011. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/j.1440-1746.2011.06821.x

Improving the quality of colonoscopy: The role of prospective clinical audit

Smith, A. J., Tutticci, N. J., Landmann, J. K., Leggett, B. A., Appleyard, M. N. and Hewett, D. G. (2010). Improving the quality of colonoscopy: The role of prospective clinical audit. Australian Gastroenterology Week 2010, Broadbeach, Queensland, Australia, 20-23 October 2010. Australia: Wiley-Blackwell Publishing Asia.

Colonoscopic features of sessile serrated polyps

Togashi, Kazutomo, Koinuma, Koji, Hewett, David G., Spring, Kevin, Horie, Hisanaga, Yasuda, Yoshikazu, Appleyard, Mark N., Jass, Jeremy and Leggett, Barbara A. (2008). Colonoscopic features of sessile serrated polyps. Digestive Disease Week 2008, San Diego, U.S., 17-22 May 2008. United States: American Society for Gastrointestinal Endoscopy; Elsevier. doi: 10.1016/j.gie.2008.03.906

E-cadherin and beta-catenin do not appear to be involved in hepatocarcinogenesis in Australia and South Africa

Herath, N., Walsh, M., Kew, M., Young, J., Leggett, B. and Macdonald, G. A. (2002). E-cadherin and beta-catenin do not appear to be involved in hepatocarcinogenesis in Australia and South Africa. 53rd Annual Meeting of the Association-for-the-Study-of-Liver-Diseases (AASLD), Boston, Massachusetts, 1-5 November, 2002. Hoboken, N. J.: Wiley Interscience.

Association of human aryl sulfotransferase, humSULT1A1, R213H polymorphism with colorectal cancer Vol. 164, nos. 1-3: Abstracts of the IXth International Congress of Toxicology, 8-13 July 2001 - Brisbane, Australia

Wong, C. F., Liyou, N. E., Leggett, B., Johnson, A. G. and McManus, M. E. (2001). Association of human aryl sulfotransferase, humSULT1A1, R213H polymorphism with colorectal cancer Vol. 164, nos. 1-3: Abstracts of the IXth International Congress of Toxicology, 8-13 July 2001 - Brisbane, Australia. IXth International Congress of Toxicology, Brisbane, Australia, 8-13 July 2001. Amsterdam: Elsevier. doi: 10.1016/S0300-483X(01)00386-9

Distinguishing pathological features of HNPCC versus sporadic MSI-H colorectal cancers

Jass, J. R., Walsh, M., Buttenshaw, R. L., Barker, M. A., Young, J. P. and Leggett, B. A. (2001). Distinguishing pathological features of HNPCC versus sporadic MSI-H colorectal cancers. 3rd Joint Meeting Leeds Castle Polyposis Group, Venice, Italy, 26-28 Apr, 2001.

A study of p14-ARF in sporadic colorectal cancer

Whitehall, V. L., Walsh, M., Jass, J. R., Young, J. and Leggett, B. A. (2000). A study of p14-ARF in sporadic colorectal cancer. 12th Lorne Cancer Conference, Lorne, Melbourne, 10-13 Feb, 2000.

Association of human aryl sulfotransferase (SULT1A1) R213H polymorphism with colorectal cancer

Wong, C., Liyou, N., Leggett, B. A., Johnson, A. and McManus, M. E. (2000). Association of human aryl sulfotransferase (SULT1A1) R213H polymorphism with colorectal cancer. Australasian Society of Clinical, Newcastle, Australia, December, 2000. Melbourne: Blackwell Scientific Publications.

HPP1: A novel transmembrane protein commonly methylated in colorectal polyps and cancers

Biden, K. G., Young, J. P., Simms, L. A., Karamatic, R., Barker, M.A., Anderson, G. J., Fitzpatrick, D. R., Jass, J. R. and Leggett, B. A. (2000). HPP1: A novel transmembrane protein commonly methylated in colorectal polyps and cancers. 91st Annual Meeting of American Association for Cancer Researh, San Francisco, 1-5 Apr, 2000. Philadelphia, U.S.A.: American Association for Cancer Research.

HPP1: A novel transmembrane protein commonly methylated in colorectal polyps and cancers

Biden, K. G., Young, J. P., Simms, L. A., Karamatic, R., Eyre, H. J., Sutherland, G. R., Herath, N., Anderson, G. J., Barker, M.A., Fitzpatrick, D. R., Jass, J. R. and Leggett, B. A. (2000). HPP1: A novel transmembrane protein commonly methylated in colorectal polyps and cancers. Australian Gastroenterology Week 2000, Hobart, 18-21 Oct, 2000. Melbourne: Blackwell Scientific.

Isolation of HPP1 alternatively spliced transcripts using 3'-race

Simms, L. A., Young, J. P., Biden, K. G., Karamatic, R., Jass, J. R. and Leggett, B. A. (2000). Isolation of HPP1 alternatively spliced transcripts using 3'-race. Australian Gastroenterology Week 2000, Hobart, 18-21 Oct, 2000. Melbourne: Blackwell Scientific.

Juvenile polyposis lesions show clonal loss of SMAD4 in epithelial as well as stromal compartments, endorsing the "gatekeeper" not the "landscaper" hypothesis

Woodford-Richens, K., Williamson, J., Bevan, S., Young, J. P., Jass, J. R., Leggett, B. A., Frayling, I., Thway, Y., Hodgson, S., Kim, J., Iwama, T., Novelli, M., Sheer, D., Poulsom, R., Wright, N.A., Houlston, R. and Tomlinson, I. (2000). Juvenile polyposis lesions show clonal loss of SMAD4 in epithelial as well as stromal compartments, endorsing the "gatekeeper" not the "landscaper" hypothesis. Pathological Society of Great Britain & Ireland 181st Meeting, Nottingham, 12-14 Jul, 2000. England: John Wiley & Sons.

Loss of heterozygosity on chromosome 22q in colorectal carcinomas and adenomas

Buttenshaw, R. L., Young, J. P., Jass, J. R. and Leggett, B. A. (2000). Loss of heterozygosity on chromosome 22q in colorectal carcinomas and adenomas. Australian Gastroenterology Week 2000, Hobart, 18-21 Oct, 2000. Melbourne: Blackwell Scientific.

Pathology and molecular features of colorectal tumours with microsatellite instability in familial and sporadic settings

Barker, M. A., Young, J. P., Buttenshaw, R. L., McKeone, D. M., Searle, J., Jass, J. R. and Leggett, B. A. (2000). Pathology and molecular features of colorectal tumours with microsatellite instability in familial and sporadic settings. Australian Gastroenterology Week 2000, Hobart, 18-21 Oct, 2000. Melbourne: Blackwell Scientific.

The "highs" and "lows" of microsatellite instability in sporadic ACPS C colorectal cancer - improving prognostic stratification for this group of patients

Wright, C.M., Dent, O. F., Barker, M.A., Newland, R. C., Chapuis, P. H., Bokey, E. L., Young, J. P., Leggett, B. A., Jass, J. R. and Macdonald, G. (2000). The "highs" and "lows" of microsatellite instability in sporadic ACPS C colorectal cancer - improving prognostic stratification for this group of patients. Australian Gastroenterology Week 2000, Hobart, 18-21 Oct, 2000. Melbourne: Blackwell Scientific.

p14-ARF and p16-INK4A - one locus, two genes frequently affected in sporadic colorectal cancer

Whitehall, V. L., Walsh, M., Jass, J. R., Young, J. P. and Leggett, B. A. (2000). p14-ARF and p16-INK4A - one locus, two genes frequently affected in sporadic colorectal cancer. Australian Gastroenterology Week 2000, Hobart, 18-21 Oct, 2000. Melbourn: Blackwell Scientific.

A case of myoepithelial carcinoma in a FAP family

Barker, M. A., Knight, M., Young, J. P., Buttenshaw, R. L., Jass, J. R. and Leggett, B. A. (1999). A case of myoepithelial carcinoma in a FAP family. From Genes to the Clinic & Beyond. Understanding & Managing Bowel Cancer, Melbourne & Lorne, 1-6 Mar, 1999.

CASPASE-5 - A target gene for mutation in the microsatellite mutator pathway of sporadic colorectal cancers?

Whitehall, V. L., Simms, L. A., Jass, J. R., Young, J. P. and Leggett, B. A. (1999). CASPASE-5 - A target gene for mutation in the microsatellite mutator pathway of sporadic colorectal cancers?. Royal Brisbane Hospital Health Care Symposium, Westpac Auditorium Bancroft Cen., QIMR, Brisbane, 21 - 27 Oct, 1999. Brisbane: Royal Brisbane Hospital.

Characterisation of a subtype of colorectal cancer combining features of the suppressor and mild mutator phenotypes

Jass, J. R., Cummings, M. C., Simms, L. A., Walsh, M., Schoch, E., Meltzer, S. J., Wright, C., Searle, J., Young, J. P. and Leggett, B. A. (1999). Characterisation of a subtype of colorectal cancer combining features of the suppressor and mild mutator phenotypes. 11th Lorne Cancer Conference, Lorne, Victoria, Australia, 11th -14th February, 1999.

Characterization of tumour infiltrating lymphocytes in microsatellite stable and microsatellite unstable colorectal cancer

Robinson, J., Biemer-Huttmann, A., Simms, L. A., Jass, J. R., Walsh, M. D., Young, J. P., Leggett, B. A. and Radford-Smith, G. L. (1999). Characterization of tumour infiltrating lymphocytes in microsatellite stable and microsatellite unstable colorectal cancer. Melbourne, 7-10 Nov, 1999.

Characterization of tumour infiltrating lymphocytes in microsatellite stable and unstable colorectal carcinoma

Robinson, J., Biemer-Huettmann, A., Simms, L. A., Jass, J. R., Walsh, M. D., Young, J. P., Leggett, B. A. and Radford-Smith, G. L. (1999). Characterization of tumour infiltrating lymphocytes in microsatellite stable and unstable colorectal carcinoma. Royal Brisbane Hospital Health Care Symposium, Brisbane, 21st - 27th October, 1999.

Early divergence of the DNA mismatch repair deficient pathway in colorectal tumorigenesis

Biden, K. G., Wright, C.M., Simms, L. A., Macdonald, G. A., Jass, J. R., Young, J. P. and Leggett, B. A. (1999). Early divergence of the DNA mismatch repair deficient pathway in colorectal tumorigenesis. From Genes to the Clinic & Beyond. Understanding & Managing Bowel Cancer, Melbourne & Lorne, 1-6 March, 1999.

Improved survival in stage C colorectal cancers exhibiting microsatellite instability

Wright, C.M., Whitehall, V. L., Dent, O. F., Walsh, M. D., Searle, J., Newland, R. C., Chapuis, P. H., Jass, J. R., Young, J. P., Leggett, B. A. and Macdonald, G. (1999). Improved survival in stage C colorectal cancers exhibiting microsatellite instability. From Genes to the Clinic & Beyond. Understanding & Managing Bowel Cancer, Melbourne & Lorne, 1 - 6 March 1999.

Loss of heterozygosity at 4q in hepatocellular carcinoma is more common in patients with hepatitis B infection

Herath, N., Kew, M. C., Young, J., Powell, L. W., Leggett, B. A. and Macdonald, G. A. (1999). Loss of heterozygosity at 4q in hepatocellular carcinoma is more common in patients with hepatitis B infection. Royal Brisbane Hospital Health Care Symposium, Westpac Auditorium Bancroft Cen., QIMR, Brisbane, 21 - 27 Oct, 1999. Brisbane: Royal Brisbane Hospital.

MSI occurs early in adenoma development in HNPCC and becomes more extensive with the development of high grade dysplasia

Iino, H., Biden, K. G., Young, J. P., Simms, L. A., Jass, J. R. and Leggett, B. A. (1999). MSI occurs early in adenoma development in HNPCC and becomes more extensive with the development of high grade dysplasia. Royal Brisbane Hospital Health Care Symposium, Brisbane, 21-27 Oct, 1999.

Microsatellite instability occurs early in adenoma development in hereditary non-polyposis colorectal cancer and becomes more extensive with the development of high grade dysplasia

Iino, H., Young, J. P., Simms, L. A., Jass, J. R. and Leggett, B. A. (1999). Microsatellite instability occurs early in adenoma development in hereditary non-polyposis colorectal cancer and becomes more extensive with the development of high grade dysplasia. The Gastroenterological Society of Queensland, Coolum, Qld, 12 - 14 June, 1999.

Microsatellite instability occurs early in adenoma development in hereditary non-polyposis colorectal cancer and becomes more extensive with the development of high grade dysplasia

Iino, H., Biden, K. G., Young, J. P., Simms, L. A., Jass, J. R. and Leggett, B. A. (1999). Microsatellite instability occurs early in adenoma development in hereditary non-polyposis colorectal cancer and becomes more extensive with the development of high grade dysplasia. Australian Gastroenterology Week 1999, Brisbane, 4-8 Oct, 1999. Carlton, Vic: Blackwell Science.

Microsatellite instability testing of tumours occurring in high-risk colorectal cancer families

Barker, M. A., Young, J. P., Webb, S. I., Buttenshaw, R. L., McKeone, D. M., Neal, J. I., Searle, J., Jass, J. R. and Leggett, B. A. (1999). Microsatellite instability testing of tumours occurring in high-risk colorectal cancer families. Royal Brisbane Hospital Health Care Symposium, Brisbane, 21-27 Oct, 1999.

Microsatellite instability testing of tumours occurring in high-risk colorectal cancer families

Barker, M. A., Young, J. P., Webb, S. I., Buttenshaw, R. L., McKeone, D. M., Neal, J. I., Searle, J., Jass, J. R. and Leggett, B. A. (1999). Microsatellite instability testing of tumours occurring in high-risk colorectal cancer families. From Genes to the Clinic & Beyond. Understanding and Managing Bowel Cancer, Melbourne & Lorne, 1 - 6 March 1999.

Microsatellite instability testing of tumours occurring in high-risk colorectal cancer families

Barker, M. A., Young, J. P., Webb, S. I., Buttenshaw, R. L., McKeone, D. M., Neal, J. I., Searle, J., Jass, J. R. and Leggett, B. A. (1999). Microsatellite instability testing of tumours occurring in high-risk colorectal cancer families. Australian Gastroenterology Week 1999, Brisbane, 4th - 8th October, 1999. Asia: Blackwell Science.

Patterns of expression of MUC1, MUC2, MUC4 and MUC5AC mucins in hyperplastic polyps, serrated adenomas and traditional adenomas of the colorectum

Biemer-Huttmann, A., Walsh, M. D., McGuckin, M. A., Ajioka, Y., Watanabe, H., Leggett, B. A. and Jass, J. R. (1999). Patterns of expression of MUC1, MUC2, MUC4 and MUC5AC mucins in hyperplastic polyps, serrated adenomas and traditional adenomas of the colorectum. Lorne, Vic., 11-14 Feb, 1999.

The effect of human bile and bile acids on duodenal epithelial cells

Karamatic, R., Donnan, K. D., Cummings, M. C., Winterford, C. M., Young, J. P., Leggett, B. A. and Radford-Smith, G. L. (1999). The effect of human bile and bile acids on duodenal epithelial cells. The Gastroenterological Society of Queensland, Coolum, Queensland, 12th - 14th June, 1999.

Up-regulation of P73 in hepatocellular carcinoma

Herath, N. I., Kew, M. C., Whitehall, V. L., Young, J. P., Powell, L. W., Leggett, B. A. and Macdonald, G. A. (1999). Up-regulation of P73 in hepatocellular carcinoma. Entering a New Era, Wyndham Anatole Hotel, Dallas, Texas, 5-9 November, 1999. Hoboken, NJ: Wiley Interscience.