The University of Queensland

Structural variants identified using non-Mendelian inheritance patterns advance the mechanistic understanding of autism spectrum disorder

Kainer, David, Templeton, Alan R., Prates, Erica T., Jacboson, Daniel, Allan, Euan R.O., Climer, Sharlee and Garvin, Michael R. (2022). Structural variants identified using non-Mendelian inheritance patterns advance the mechanistic understanding of autism spectrum disorder. Human Genetics and Genomics Advances, 4 (1) 100150, 1-21. doi: 10.1016/j.xhgg.2022.100150

Evaluating the performance of random forest and iterative random forest based methods when applied to gene expression data

Walker, Angelica M., Cliff, Ashley, Romero, Jonathon, Shah, Manesh B., Jones, Piet, Felipe Machado Gazolla, Joao Gabriel, Jacobson, Daniel A and Kainer, David (2022). Evaluating the performance of random forest and iterative random forest based methods when applied to gene expression data. Computational and Structural Biotechnology Journal, 20, 3372-3386. doi: 10.1016/j.csbj.2022.06.037

High marker density GWAS provides novel insights into the genomic architecture of terpene oil yield in Eucalyptus

Kainer, David, Padovan, Amanda, Degenhardt, Joerg, Krause, Sandra, Mondal, Prodyut, Foley, William J. and Külheim, Carsten (2019). High marker density GWAS provides novel insights into the genomic architecture of terpene oil yield in Eucalyptus. New Phytologist, 223 (3), 1489-1504. doi: 10.1111/nph.15887

Accuracy of Genomic Prediction for Foliar Terpene Traits in Eucalyptus polybractea

Kainer, David, Stone, Eric A., Padovan, Amanda, Foley, William J. and Külheim, Carsten (2018). Accuracy of Genomic Prediction for Foliar Terpene Traits in Eucalyptus polybractea. G3: Genes, Genomes, Genetics, 8 (8), 2573-2583. doi: 10.1534/g3.118.200443

Plant-Derived Terpenes: A Feedstock for Specialty Biofuels

Mewalal, Ritesh, Rai, Durgesh K., Kainer, David, Chen, Feng, Külheim, Carsten, Peter, Gary F. and Tuskan, Gerald A. (2017). Plant-Derived Terpenes: A Feedstock for Specialty Biofuels. Trends in Biotechnology, 35 (3), 227-240. doi: 10.1016/j.tibtech.2016.08.003

High dimensional predictions of suicide risk in 4.2 million US Veterans using ensemble transfer learning

Dhaubhadel, Sayera, Ganguly, Kumkum, Ribeiro, Ruy M., Cohn, Judith D., Hyman, James M., Hengartner, Nicolas W., Kolade, Beauty, Singley, Anna, Bhattacharya, Tanmoy, Finley, Patrick, Levin, Drew, Thelen, Haedi, Cho, Kelly, Costa, Lauren, Ho, Yuk-Lam, Justice, Amy C., Pestian, John, Santel, Daniel, Zamora-Resendiz, Rafael, Crivelli, Silvia, Tamang, Suzanne, Martins, Susana, Trafton, Jodie, Oslin, David W., Beckham, Jean C., Kimbrel, Nathan A., Agarwal, Khushbu, Ashley-Koch, Allison E., Aslan, Mihaela ... McMahon, Benjamin H. (2024). High dimensional predictions of suicide risk in 4.2 million US Veterans using ensemble transfer learning. Scientific Reports, 14 (1) 1793. doi: 10.1038/s41598-024-51762-9

78. NETWORK BIOLOGY ALGORITHMS IDENTIFY BIOLOGICAL PATHWAYS UNDERLYING CIGARETTE SMOKING BEHAVIORS

Sullivan, Kyle, Miller, J. Izaak, Kainer, David, Lane, Matthew, Cashman, Mikaela, Garvin, Michael R., Townsend, Alice, Kruse, Peter, Quach, Bryan C., Willis, Caryn, Xu, Ke, Aouzierat, Bradley E., Johnson, Eric O., Hancock, Dana B. and Jacobson, Daniel (2023). 78. NETWORK BIOLOGY ALGORITHMS IDENTIFY BIOLOGICAL PATHWAYS UNDERLYING CIGARETTE SMOKING BEHAVIORS. European Neuropsychopharmacology, 75, S98-S99. doi: 10.1016/j.euroneuro.2023.08.183

A glimpse into the fungal metabolomic abyss: Novel network analysis reveals relationships between exogenous compounds and their outputs

Gopalakrishnan Meena, Muralikrishnan, Lane, Matthew J., Tannous, Joanna, Carrell, Alyssa A., Abraham, Paul E., Giannone, Richard J., Ané, Jean-Michel, Keller, Nancy P., Labbé, Jesse L., Kainer, David, Jacobson, Daniel A. and Rush, Tomás A. (2023). A glimpse into the fungal metabolomic abyss: Novel network analysis reveals relationships between exogenous compounds and their outputs. PNAS Nexus, 2 (10) pgad322, 1-15. doi: 10.1093/pnasnexus/pgad322

Quantum biological insights into CRISPR-Cas9 sgRNA efficiency from explainable-AI driven feature engineering

Noshay, Jaclyn M., Walker, Tyler, Alexander, William G., Klingeman, Dawn M., Romero, Jonathon, Walker, Angelica M., Prates, Erica, Eckert, Carrie, Irle, Stephan, Kainer, David and Jacobson, Daniel A. (2023). Quantum biological insights into CRISPR-Cas9 sgRNA efficiency from explainable-AI driven feature engineering. Nucleic Acids Research, 51 (19), 10147-10161. doi: 10.1093/nar/gkad736

Validation of a metabolite–GWAS network for Populus trichocarpa family 1 UDP-glycosyltransferases

Saint-Vincent, Patricia M. B., Furches, Anna, Galanie, Stephanie, Teixeira Prates, Erica, Aldridge, Jessa L., Labbe, Audrey, Zhao, Nan, Martin, Madhavi Z., Ranjan, Priya, Jones, Piet, Kainer, David, Kalluri, Udaya C., Chen, Jin-Gui, Muchero, Wellington, Jacobson, Daniel A. and Tschaplinski, Timothy J. (2023). Validation of a metabolite–GWAS network for Populus trichocarpa family 1 UDP-glycosyltransferases. Frontiers in Plant Science, 14 1210146. doi: 10.3389/fpls.2023.1210146

Few-shot learning enables population-scale analysis of leaf traits in Populus trichocarpa

Lagergren, John Heikki, Pavicic, Mirko, Chhetri, Hari B., York, Larry M., Hyatt, Doug, Kainer, David, Rutter, Erica M., Flores, Kevin, Bailey-Bale, Jack, Klein, Marie, Taylor, Gail, Jacobson, Daniel and Streich, Jared (2023). Few-shot learning enables population-scale analysis of leaf traits in Populus trichocarpa. Plant Phenomics, 5 0072, 1-18. doi: 10.34133/plantphenomics.0072

Exploring the role of plant lysin motif receptor-like kinases in regulating plant-microbe interactions in the bioenergy crop Populus

Cope, Kevin R., Prates, Erica T., Miller, John I., Demerdash, Omar N.A., Shah, Manesh, Kainer, David, Cliff, Ashley, Sullivan, Kyle A., Cashman, Mikaela, Lane, Matthew, Matthiadis, Anna, Labbé, Jesse, Tschaplinski, Timothy J., Jacobson, Daniel A. and Kalluri, Udaya C. (2023). Exploring the role of plant lysin motif receptor-like kinases in regulating plant-microbe interactions in the bioenergy crop Populus. Computational and Structural Biotechnology Journal, 21, 1122-1139. doi: 10.1016/j.csbj.2022.12.052

Genetics of varicose veins reveals polygenic architecture and genetic overlap with arterial and venous disease

Levin, Michael G., Huffman, Jennifer E., Verma, Anurag, Sullivan, Kyle A., Rodriguez, Alexis A., Kainer, David, Garvin, Michael R., Lane, Matthew, Cashman, Mikaela, Miller, J. Izaak, Won, Hyejung, Li, Binglan, Luo, Yuan, Jarvik, Gail P., Hakonarson, Hakon, Jasper, Elizabeth A., Bick, Alexander G., Tsao, Philip S., Ritchie, Marylyn D., Jacobson, Daniel A., Madduri, Ravi K. and Damrauer, Scott M. (2023). Genetics of varicose veins reveals polygenic architecture and genetic overlap with arterial and venous disease. Nature Cardiovascular Research, 2 (1), 44-57. doi: 10.1038/s44161-022-00196-5

Lipo-chitooligosaccharides induce specialized fungal metabolite profiles that modulate bacterial growth

Rush, Tomás A., Tannous, Joanna, Lane, Matthew J., Meena, Muralikrishnan Gopalakrishnan, Carrell, Alyssa A., Golan, Jacob J., Drott, Milton T., Cottaz, Sylvain, Fort, Sébastien, Ané, Jean-Michel, Keller, Nancy P., Pelletier, Dale A., Jacobson, Daniel A., Kainer, David, Abraham, Paul E., Giannone, Richard J. and Labbé, Jesse L. (2022). Lipo-chitooligosaccharides induce specialized fungal metabolite profiles that modulate bacterial growth. mSystems, 7 (6). doi: 10.1128/msystems.01052-22

Structural variants identified using non-Mendelian inheritance patterns advance the mechanistic understanding of autism spectrum disorder

Kainer, David, Templeton, Alan R., Prates, Erica T., Jacboson, Daniel, Allan, Euan R.O., Climer, Sharlee and Garvin, Michael R. (2022). Structural variants identified using non-Mendelian inheritance patterns advance the mechanistic understanding of autism spectrum disorder. Human Genetics and Genomics Advances, 4 (1) 100150, 1-21. doi: 10.1016/j.xhgg.2022.100150

Evaluating the performance of random forest and iterative random forest based methods when applied to gene expression data

Walker, Angelica M., Cliff, Ashley, Romero, Jonathon, Shah, Manesh B., Jones, Piet, Felipe Machado Gazolla, Joao Gabriel, Jacobson, Daniel A and Kainer, David (2022). Evaluating the performance of random forest and iterative random forest based methods when applied to gene expression data. Computational and Structural Biotechnology Journal, 20, 3372-3386. doi: 10.1016/j.csbj.2022.06.037

The genetic architecture of nitrogen use efficiency in switchgrass (Panicum virgatum L.)

Shrestha, Vivek, Chhetri, Hari B., Kainer, David, Xu, Yaping, Hamilton, Lance, Piasecki, Cristiano, Wolfe, Ben, Wang, Xueyan, Saha, Malay, Jacobson, Daniel, Millwood, Reginald J., Mazarei, Mitra and Stewart, C. Neal (2022). The genetic architecture of nitrogen use efficiency in switchgrass (Panicum virgatum L.). Frontiers in Plant Science, 13 893610. doi: 10.3389/fpls.2022.893610

Characterization of terpene biosynthesis in Melaleuca quinquenervia and ecological consequences of terpene accumulation during myrtle rust infection

Hsieh, Ji-Fan, Krause, Sandra T., Kainer, David, Degenhardt, Jörg, Foley, William J. and Külheim, Carsten (2021). Characterization of terpene biosynthesis in Melaleuca quinquenervia and ecological consequences of terpene accumulation during myrtle rust infection. Plant-Environment Interactions, 2 (4), 177-193. doi: 10.1002/pei3.10056

Potentially adaptive SARS-CoV-2 mutations discovered with novel spatiotemporal and explainable AI models

Garvin, Michael R., Prates, Erica T., Pavicic, Mirko, Jones, Piet, Amos, B. Kirtley, Geiger, Armin, Shah, Manesh B., Streich, Jared, Gazolla, Joao Gabriel Felipe Machado, Kainer, David, Cliff, Ashley, Romero, Jonathon, Keith, Nathan, Brown, James B. and Jacobson, Daniel (2020). Potentially adaptive SARS-CoV-2 mutations discovered with novel spatiotemporal and explainable AI models. Genome Biology, 21 (1) 304, 1-26. doi: 10.1186/s13059-020-02191-0

Modeled economic potential for Eucalyptus spp. production for jet fuel additives in the United States

Davis, Maggie R., Kainer, David, Tuskan, Gerald A., Langholtz, Matthew H., Hellwinckel, Chad M., Shedden, Magen and Eaton, Laurence (2020). Modeled economic potential for Eucalyptus spp. production for jet fuel additives in the United States. Biomass and Bioenergy, 143 105807, 1-10. doi: 10.1016/j.biombioe.2020.105807

Genome-wide association study of wood anatomical and morphological traits in Populus trichocarpa

Chhetri, Hari B., Furches, Anna, Macaya-Sanz, David, Walker, Alejandro R., Kainer, David, Jones, Piet, Harman-Ware, Anne E., Tschaplinski, Timothy J., Jacobson, Daniel, Tuskan, Gerald A. and DiFazio, Stephen P. (2020). Genome-wide association study of wood anatomical and morphological traits in Populus trichocarpa. Frontiers in Plant Science, 11 545748. doi: 10.3389/fpls.2020.545748

A phylogenomic approach reveals a low somatic mutation rate in a long-lived plant

Orr, Adam J., Padovan, Amanda, Kainer, David, Kulheim, Carsten, Bromham, Lindell, Bustos-Segura, Carlos, Foley, William, Haff, Tonya, Hsieh, Ji-Fan, Morales-Suarez, Alejandro, Cartwright, Reed A. and Lanfear, Robert (2020). A phylogenomic approach reveals a low somatic mutation rate in a long-lived plant. Royal Society of London. Proceedings B. Biological Sciences, 287 (1922) 20192364, 20192364. doi: 10.1098/rspb.2019.2364

Can exascale computing and explainable artificial intelligence applied to plant biology deliver on the United Nations sustainable development goals?

Streich, Jared, Romero, Jonathon, Gazolla, João Gabriel Felipe Machado, Kainer, David, Cliff, Ashley, Prates, Erica Teixeira, Brown, James B, Khoury, Sacha, Tuskan, Gerald A, Garvin, Michael, Jacobson, Daniel and Harfouche, Antoine L (2020). Can exascale computing and explainable artificial intelligence applied to plant biology deliver on the United Nations sustainable development goals?. Current Opinion in Biotechnology, 61, 217-225. doi: 10.1016/j.copbio.2020.01.010

The draft nuclear genome assembly of Eucalyptus pauciflora: a pipeline for comparing de novo assemblies

Wang, Weiwen, Das, Ashutosh, Kainer, David, Schalamun, Miriam, Morales-Suarez, Alejandro, Schwessinger, Benjamin and Lanfear, Robert (2020). The draft nuclear genome assembly of Eucalyptus pauciflora: a pipeline for comparing de novo assemblies. GigaScience, 9 (1). doi: 10.1093/gigascience/giz160

A high-performance computing implementation of iterative random forest for the creation of predictive expression networks

Cliff, Ashley, Romero, Jonathon, Kainer, David, Walker, Angelica, Furches, Anna and Jacobson, Daniel (2019). A high-performance computing implementation of iterative random forest for the creation of predictive expression networks. Genes, 10 (12) 996, 1-13. doi: 10.3390/genes10120996

Accelerating climate resilient plant breeding by applying next-generation artificial intelligence

Harfouche, Antoine L., Jacobson, Daniel A., Kainer, David, Romero, Jonathon C., Harfouche, Antoine H., Mugnozza, Giuseppe Scarascia, Moshelion, Menachem, Tuskan, Gerald A., Keurentjes, Joost J. B. and Altman, Arie (2019). Accelerating climate resilient plant breeding by applying next-generation artificial intelligence. Trends in Biotechnology, 37 (11), 1217-1235. doi: 10.1016/j.tibtech.2019.05.007

Finding new cell wall regulatory genes in populus trichocarpa using multiple lines of evidence

Furches, Anna, Kainer, David, Weighill, Deborah, Large, Annabel, Jones, Piet, Walker, Angelica M., Romero, Jonathon, Gazolla, Joao Gabriel Felipe Machado, Joubert, Wayne, Shah, Manesh, Streich, Jared, Ranjan, Priya, Schmutz, Jeremy, Sreedasyam, Avinash, Macaya-Sanz, David, Zhao, Nan, Martin, Madhavi Z., Rao, Xiaolan, Dixon, Richard A., DiFazio, Stephen, Tschaplinski, Timothy J., Chen, Jin-Gui, Tuskan, Gerald A. and Jacobson, Daniel (2019). Finding new cell wall regulatory genes in populus trichocarpa using multiple lines of evidence. Frontiers in Plant Science, 10 1249. doi: 10.3389/fpls.2019.01249

Multitrait genome-wide association analysis of Populus trichocarpa identifies key polymorphisms controlling morphological and physiological traits

Chhetri, Hari B., Macaya-Sanz, David, Kainer, David, Biswal, Ajaya K., Evans, Luke M., Chen, Jin-Gui, Collins, Cassandra, Hunt, Kimberly, Mohanty, Sushree S., Rosenstiel, Todd, Ryno, David, Winkeler, Kim, Yang, Xiaohan, Jacobson, Daniel, Mohnen, Debra, Muchero, Wellington, Strauss, Steven H., Tschaplinski, Timothy J., Tuskan, Gerald A. and DiFazio, Stephen P. (2019). Multitrait genome-wide association analysis of Populus trichocarpa identifies key polymorphisms controlling morphological and physiological traits. New Phytologist, 223 (1), 293-309. doi: 10.1111/nph.15777

High marker density GWAS provides novel insights into the genomic architecture of terpene oil yield in Eucalyptus

Kainer, David, Padovan, Amanda, Degenhardt, Joerg, Krause, Sandra, Mondal, Prodyut, Foley, William J. and Külheim, Carsten (2019). High marker density GWAS provides novel insights into the genomic architecture of terpene oil yield in Eucalyptus. New Phytologist, 223 (3), 1489-1504. doi: 10.1111/nph.15887

MinIONQC: fast and simple quality control for MinION sequencing data

Lanfear, R., Schalamun, M., Kainer, D., Wang, W. and Schwessinger, B. (2019). MinIONQC: fast and simple quality control for MinION sequencing data. Bioinformatics, 35 (3), 523-525. doi: 10.1093/bioinformatics/bty654

Harnessing the MinION: An example of how to establish long-read sequencing in a laboratory using challenging plant tissue from Eucalyptus pauciflora

Schalamun, Miriam, Nagar, Ramawatar, Kainer, David, Beavan, Eleanor, Eccles, David, Rathjen, John P., Lanfear, Robert and Schwessinger, Benjamin (2019). Harnessing the MinION: An example of how to establish long-read sequencing in a laboratory using challenging plant tissue from Eucalyptus pauciflora. Molecular Ecology Resources, 19 (1), 77-89. doi: 10.1111/1755-0998.12938

Assembly of chloroplast genomes with long- and short-read data: a comparison of approaches using <i>Eucalyptus pauciflora</i> as a test case

Wang, Weiwen, Schalamun, Miriam, Morales-Suarez, Alejandro, Kainer, David, Schwessinger, Benjamin and Lanfear, Robert (2018). Assembly of chloroplast genomes with long- and short-read data: a comparison of approaches using Eucalyptus pauciflora as a test case. Bmc Genomics, 19 (1) 977. doi: 10.1186/s12864-018-5348-8

High Throughput Screening Technologies in Biomass Characterization

Decker, Stephen R., Harman-Ware, Anne E., Happs, Renee M., Wolfrum, Edward J., Tuskan, Gerald A., Kainer, David, Oguntimein, Gbekeloluwa B., Rodriguez, Miguel, Weighill, Deborah, Jones, Piet and Jacobson, Daniel (2018). High Throughput Screening Technologies in Biomass Characterization. Frontiers in Energy Research, 6 120. doi: 10.3389/fenrg.2018.00120

Accuracy of Genomic Prediction for Foliar Terpene Traits in Eucalyptus polybractea

Kainer, David, Stone, Eric A., Padovan, Amanda, Foley, William J. and Külheim, Carsten (2018). Accuracy of Genomic Prediction for Foliar Terpene Traits in Eucalyptus polybractea. G3: Genes, Genomes, Genetics, 8 (8), 2573-2583. doi: 10.1534/g3.118.200443

Transcriptome analysis of terpene chemotypes of Melaleuca alternifolia across different tissues

Bustos‐Segura, Carlos, Padovan, Amanda, Kainer, David, Foley, William J. and Külheim, Carsten (2017). Transcriptome analysis of terpene chemotypes of Melaleuca alternifolia across different tissues. Plant, Cell & Environment, 40 (10), 2406-2425. doi: 10.1111/pce.13048

Assessment of a non-destructive method to predict oil yield in Eucalyptus polybractea (blue mallee)

Kainer, David, Bush, David, Foley, William J. and Külheim, Carsten (2017). Assessment of a non-destructive method to predict oil yield in Eucalyptus polybractea (blue mallee). Industrial Crops and Products, 102, 32-44. doi: 10.1016/j.indcrop.2017.03.008

Plant-Derived Terpenes: A Feedstock for Specialty Biofuels

Mewalal, Ritesh, Rai, Durgesh K., Kainer, David, Chen, Feng, Külheim, Carsten, Peter, Gary F. and Tuskan, Gerald A. (2017). Plant-Derived Terpenes: A Feedstock for Specialty Biofuels. Trends in Biotechnology, 35 (3), 227-240. doi: 10.1016/j.tibtech.2016.08.003

Genomic approaches to selection in outcrossing perennials: focus on essential oil crops

Kainer, David, Lanfear, Robert, Foley, William J. and Külheim, Carsten (2015). Genomic approaches to selection in outcrossing perennials: focus on essential oil crops. Theoretical and Applied Genetics, 128 (12), 2351-2365. doi: 10.1007/s00122-015-2591-0

The effects of partitioning on phylogenetic inference

Kainer, David and Lanfear, Robert (2015). The effects of partitioning on phylogenetic inference. Molecular Biology and Evolution, 32 (6), 1611-1627. doi: 10.1093/molbev/msv026

Selecting optimal partitioning schemes for phylogenomic datasets

Lanfear, Robert, Calcott, Brett, Kainer, David, Mayer, Christoph and Stamatakis, Alexandros (2014). Selecting optimal partitioning schemes for phylogenomic datasets. BMC Evolutionary Biology, 14 (1) 82. doi: 10.1186/1471-2148-14-82

Attacking the opioid epidemic: Determining the epistatic and pleiotropic genetic architectures for chronic pain and opioid addiction

Joubert, Wayne, Weighill, Deborah, Kainer, David, Climer, Sharlee, Justice, Amy, Fagnan, Kjiersten and Jacobson, Daniel (2019). Attacking the opioid epidemic: Determining the epistatic and pleiotropic genetic architectures for chronic pain and opioid addiction. International Conference on High Performance Computing, Networking, Storage, and Analysis (SC), Dallas, TX United States, 11-16 November 2018. Piscataway, NJ United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/SC.2018.00060

Methods for controlling cell wall biosynthesis and genetically modified plants

Jacobson, Daniel, Tschaplinski, Timothy J., Kainer, David, Weighill, Deborah A. and Furches, Anna K. (2023). Methods for controlling cell wall biosynthesis and genetically modified plants. 11725215.

RWRtoolkit -a set of command-line and R tools for performing Random-walk with Restart analyses on multiplex networks in any species

Kainer, David, Lane, Matthew, Sullivan, Kyle A., Cashman, Michaela and Miller, John Izaak (2022). RWRtoolkit -a set of command-line and R tools for performing Random-walk with Restart analyses on multiplex networks in any species. Oak Ridge, TN, United States: Oak Ridge National Laboratory.