Professor Waldemar Vollmer

Professorial Research Fellow & Grou

Institute for Molecular Bioscience

w.vollmer@imb.uq.edu.au
+61 7 334 62055

Overview

Overview

Professor Waldemar Vollmer is a microbiologist working on the structure and biogenesis of the bacterial cell wall in various model bacteria and a range of pathogenic and environmental bacteria. He is particularly interested in how bacteria enlarge their cell wall when they grow and divide, and how antibiotics inhibit cell wall synthesis to kill bacteria. Antimicrobial resistance (AMR) is a global problem that is predicted to claim 10 million lives annually by the year 2050 if no new antibiotics are developed. Currently the pipeline of antibiotic development is almost empty and mostly limited to slightly modified versions to existing antibiotics. Professor Vollmer addresses the problem of AMR by generating tailored assays for the development of novel antibiotics that target AMR bacteria.

Collaborations: Professor Vollmer collaborates world-wide with more than 50 researchers at top national and international institutions on cell wall topics in over 30 different bacteria. These topics include: structure and composition of the cell wall and its role in maintaining cell morphology; molecular mechanisms of cell envelope biogenesis; role of new cell wall modifying enzymes in the interaction of pathogenic bacteria with components of the immune system; mechanisms of antibiotic resistance and targeting of cell wall biogenesis by new antibiotics.

Funding and Publications: Professor Vollmer has been awarded more than $15 million funding from research councils and charities in Germany, UK, Europe and USA. He has published more than 200 articles in international journals and has been recognised as a Highly Cited Researcher in Microbiology.

Honours and Awards: Professor Vollmer has been elected to Fellow of the American Academy of Microbiology (2014) and European Academy of Microbiology (2018). He received the annual Academic Distinction Awards from the Vice Chancellor of Newcastle University (2014), has been awarded a Distinguished Scientist Visiting Scholarships at Ben-Gurion University of the Negev (Israel, 2012) and a Visiting Professorship at the University of Cagliari (Italy, 2015), and won a Wellcome Trust Senior Investigator Award (2014). He has co-organised the 2018 Gordon Conference (GRC) "Bacterial Cell Surfaces" (Mt Snow, USA) and the 2016 EMBO Workshop "Bacterial Cell Division: Orchestrating the Ring Cycle" (Prague, Czech Republic).

Short Biography: Prof Waldemar Vollmer has studied chemistry at the University of Applied Sciences in Reutlingen (Germany) and University of Basel (Switzerland). In 1998 he obtained a PhD degree (Dr.rer.nat.) from the University of Tübingen (Germany) for his work on cell wall synthesis in the model bacterium Escherichia coli undertaken at the Max Planck Institute for Developmental Biology. During his postdoctoral studies at the Rockefeller University (New York, USA) he discovered novel cell wall enzymes that are crucial for the virulence of the pathogenic bacterium Streptococcus pneumoiae. In 2003 he was appointed Assistant Professor at the University of Tübingen and moved 2007 to the Centre for Bacterial Cell Biology at Newcastle University (UK), where he worked as Professor of Bacterial Biochemistry on various bacterial cell wall topics in a range of different bacteria. Since April 2023 he is Professorial Research Fellow and Group Leader at the Centre for Superbug Solutions, Institute for Molecular Bioscience (IMB) at the University of Queensland.

Research Impacts

Professor Vollmer's basic research on the bacterial cell envelope has led to key advances in our understanding of bacterial cell function and has discovered molecular mechanisms that can be exploited for antibiotic development.

Key research outputs: Prof Vollmer's group has discovered mechanisms of PG biosynthesis and its regulation, novel cell wall enzymes, and mechanisms of coordination between PG synthesis and outer membrane biogenesis. These discoveries provided the first molecular insights into how bacteria robustly maintain, enlarge and modify their cell envelope when they propagate in diverse environments and under stress conditions, and when exposed to antibiotics.

Key capabilities: Prof Vollmer's group is expert in the analysis of the composition of peptidoglycan, the key shape-maintaining and stress-bearing component of the bacterial cell envelope. They also discover new cell wall enzymes and study the activities and interactions of of key cell wall synthases and hydrolases (lysins or autolysins). They are also expert in determining the cleavage site of cell wall-degrading lysins and establishing biochemical assays for cell wall enzymes, for studying their inhibition by antibiotics. They combine their molecular biology work with studies on the physiology of bacterial cells impaired in cell wall biogenesis.

Publications

Journal Article: Peptidoglycan maturation controls outer membrane protein assembly

Mamou, Gideon, Corona, Federico, Cohen-Khait, Ruth, Housden, Nicholas G., Yeung, Vivian, Sun, Dawei, Sridhar, Pooja, Pazos, Manuel, Knowles, Timothy J., Kleanthous, Colin and Vollmer, Waldemar (2022). Peptidoglycan maturation controls outer membrane protein assembly. Nature, 606 (7916), 953-959. doi: 10.1038/s41586-022-04834-7
Journal Article: Real-time monitoring of peptidoglycan synthesis by membrane-reconstituted penicillin-binding proteins

Hernandez-Rocamora, Victor M., Baranova, Natalia, Peters, Katharina, Breukink, Eefjan, Loose, Martin and Vollmer, Waldemar (2021). Real-time monitoring of peptidoglycan synthesis by membrane-reconstituted penicillin-binding proteins. eLife, 10, 1-32. doi: 10.7554/eLife.61525
Journal Article: Regulation of peptidoglycan synthesis and remodelling

Egan, Alexander J. F., Errington, Jeff and Vollmer, Waldemar (2020). Regulation of peptidoglycan synthesis and remodelling. Nature Reviews. Microbiology, 18 (8), 446-460. doi: 10.1038/s41579-020-0366-3
Journal Article: Outer membrane lipoprotein NlpI scaffolds peptidoglycan hydrolases within multi-enzyme complexes in Escherichia coli

Banzhaf, Manuel, Yau, Hamish C. L., Verheul, Jolanda, Lodge, Adam, Kritikos, George, Mateus, Andre, Cordier, Baptiste, Hov, Ann Kristin, Stein, Frank, Wartel, Morgane, Pazos, Manuel, Solovyova, Alexandra S., Breukink, Eefjan, van Teeffelen, Sven, Savitski, Mikhail M., den Blaauwen, Tanneke, Typas, Athanasios and Vollmer, Waldemar (2020). Outer membrane lipoprotein NlpI scaffolds peptidoglycan hydrolases within multi-enzyme complexes in Escherichia coli. The EMBO Journal, 39 (5) e102246, 1-20. doi: 10.15252/embj.2019102246
Journal Article: Z-ring membrane anchors associate with cell wall synthases to initiate bacterial cell division

Pazos, Manuel, Peters, Katharina, Casanova, Mercedes, Palacios, Pilar, VanNieuwenhze, Michael, Breukink, Eefjan, Vicente, Miguel and Vollmer, Waldemar (2018). Z-ring membrane anchors associate with cell wall synthases to initiate bacterial cell division. Nature Communications, 9 (1) 5090. doi: 10.1038/s41467-018-07559-2
Journal Article: Copper inhibits peptidoglycan LD-transpeptidases suppressing beta-lactam resistance due to bypass of penicillin-binding proteins

Peters, Katharina, Pazos, Manuel, Edoo, Zainab, Hugonnet, Jean-Emmanuel, Martorana, Alessandra M., Polissi, Alessandra, VanNieuwenhze, Michael S., Arthur, Michel and Vollmer, Waldemar (2018). Copper inhibits peptidoglycan LD-transpeptidases suppressing beta-lactam resistance due to bypass of penicillin-binding proteins. Proceedings of the National Academy of Sciences of the United States of America, 115 (42), 10786-10791. doi: 10.1073/pnas.1809285115
Journal Article: Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division

Gray, Andrew N., Egan, Alexander J. F., van't Veer, Inge L., Verheul, Jolanda, Colavin, Alexandre, Koumoutsi, Alexandra, Biboy, Jacob, Altelaar, A. F. Maarten, Damen, Mirjam J., Huang, Kerwyn Casey, Simorre, Jean-Pierre, Breukink, Eefjan, den Blaauwen, Tanneke, Typas, Athanasios, Gross, Carol A. and Vollmer, Waldemar (2015). Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division. Elife, 4 e07118. doi: 10.7554/eLife.07118
Journal Article: Outer-membrane lipoprotein LpoB spans the periplasm to stimulate the peptidoglycan synthase PBP1B

Egan, Alexander J. F., Jean, Nicolas L., Koumoutsi, Alexandra, Bougault, Catherine M., Biboy, Jacob, Sassine, Jad, Solovyova, Alexandra S., Breukink, Eefjan, Typas, Athanasios, Vollmer, Waldemar and Simorre, Jean-Pierre (2014). Outer-membrane lipoprotein LpoB spans the periplasm to stimulate the peptidoglycan synthase PBP1B. Proceedings of the National Academy of Sciences of the United States of America, 111 (22), 8197-8202. doi: 10.1073/pnas.1400376111
Journal Article: Regulation of Peptidoglycan Synthesis by Outer-Membrane Proteins

Typas, Athanasios, Banzhaf, Manuel, van Saparoea, Bart van den Berg, Verheul, Jolanda, Biboy, Jacob, Nichols, Robert J., Zietek, Matylda, Beilharz, Katrin, Kannenberg, Kai, von Rechenberg, Moritz, Breukink, Eefjan, den Blaauwen, Tanneke, Gross, Carol A. and Vollmer, Waldemar (2010). Regulation of Peptidoglycan Synthesis by Outer-Membrane Proteins. Cell, 143 (7), 1097-1109. doi: 10.1016/j.cell.2010.11.038

View all Publications

Supervision

Dissecting the bacterial cell envelope for antibiotic drug discovery

Doctor Philosophy
Targeting bacterial cell envelope coordination for antibiotic drug discovery

Doctor Philosophy
Novel assays for antibiotic discovery

Doctor Philosophy

View all Supervision

Publications

Featured Publications

Peptidoglycan maturation controls outer membrane protein assembly

Mamou, Gideon, Corona, Federico, Cohen-Khait, Ruth, Housden, Nicholas G., Yeung, Vivian, Sun, Dawei, Sridhar, Pooja, Pazos, Manuel, Knowles, Timothy J., Kleanthous, Colin and Vollmer, Waldemar (2022). Peptidoglycan maturation controls outer membrane protein assembly. Nature, 606 (7916), 953-959. doi: 10.1038/s41586-022-04834-7
Real-time monitoring of peptidoglycan synthesis by membrane-reconstituted penicillin-binding proteins

Hernandez-Rocamora, Victor M., Baranova, Natalia, Peters, Katharina, Breukink, Eefjan, Loose, Martin and Vollmer, Waldemar (2021). Real-time monitoring of peptidoglycan synthesis by membrane-reconstituted penicillin-binding proteins. eLife, 10, 1-32. doi: 10.7554/eLife.61525
Regulation of peptidoglycan synthesis and remodelling

Egan, Alexander J. F., Errington, Jeff and Vollmer, Waldemar (2020). Regulation of peptidoglycan synthesis and remodelling. Nature Reviews. Microbiology, 18 (8), 446-460. doi: 10.1038/s41579-020-0366-3
Outer membrane lipoprotein NlpI scaffolds peptidoglycan hydrolases within multi-enzyme complexes in Escherichia coli

Banzhaf, Manuel, Yau, Hamish C. L., Verheul, Jolanda, Lodge, Adam, Kritikos, George, Mateus, Andre, Cordier, Baptiste, Hov, Ann Kristin, Stein, Frank, Wartel, Morgane, Pazos, Manuel, Solovyova, Alexandra S., Breukink, Eefjan, van Teeffelen, Sven, Savitski, Mikhail M., den Blaauwen, Tanneke, Typas, Athanasios and Vollmer, Waldemar (2020). Outer membrane lipoprotein NlpI scaffolds peptidoglycan hydrolases within multi-enzyme complexes in Escherichia coli. The EMBO Journal, 39 (5) e102246, 1-20. doi: 10.15252/embj.2019102246
Z-ring membrane anchors associate with cell wall synthases to initiate bacterial cell division

Pazos, Manuel, Peters, Katharina, Casanova, Mercedes, Palacios, Pilar, VanNieuwenhze, Michael, Breukink, Eefjan, Vicente, Miguel and Vollmer, Waldemar (2018). Z-ring membrane anchors associate with cell wall synthases to initiate bacterial cell division. Nature Communications, 9 (1) 5090. doi: 10.1038/s41467-018-07559-2
Copper inhibits peptidoglycan LD-transpeptidases suppressing beta-lactam resistance due to bypass of penicillin-binding proteins

Peters, Katharina, Pazos, Manuel, Edoo, Zainab, Hugonnet, Jean-Emmanuel, Martorana, Alessandra M., Polissi, Alessandra, VanNieuwenhze, Michael S., Arthur, Michel and Vollmer, Waldemar (2018). Copper inhibits peptidoglycan LD-transpeptidases suppressing beta-lactam resistance due to bypass of penicillin-binding proteins. Proceedings of the National Academy of Sciences of the United States of America, 115 (42), 10786-10791. doi: 10.1073/pnas.1809285115
Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division

Gray, Andrew N., Egan, Alexander J. F., van't Veer, Inge L., Verheul, Jolanda, Colavin, Alexandre, Koumoutsi, Alexandra, Biboy, Jacob, Altelaar, A. F. Maarten, Damen, Mirjam J., Huang, Kerwyn Casey, Simorre, Jean-Pierre, Breukink, Eefjan, den Blaauwen, Tanneke, Typas, Athanasios, Gross, Carol A. and Vollmer, Waldemar (2015). Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division. Elife, 4 e07118. doi: 10.7554/eLife.07118
Outer-membrane lipoprotein LpoB spans the periplasm to stimulate the peptidoglycan synthase PBP1B

Egan, Alexander J. F., Jean, Nicolas L., Koumoutsi, Alexandra, Bougault, Catherine M., Biboy, Jacob, Sassine, Jad, Solovyova, Alexandra S., Breukink, Eefjan, Typas, Athanasios, Vollmer, Waldemar and Simorre, Jean-Pierre (2014). Outer-membrane lipoprotein LpoB spans the periplasm to stimulate the peptidoglycan synthase PBP1B. Proceedings of the National Academy of Sciences of the United States of America, 111 (22), 8197-8202. doi: 10.1073/pnas.1400376111
Regulation of Peptidoglycan Synthesis by Outer-Membrane Proteins

Typas, Athanasios, Banzhaf, Manuel, van Saparoea, Bart van den Berg, Verheul, Jolanda, Biboy, Jacob, Nichols, Robert J., Zietek, Matylda, Beilharz, Katrin, Kannenberg, Kai, von Rechenberg, Moritz, Breukink, Eefjan, den Blaauwen, Tanneke, Gross, Carol A. and Vollmer, Waldemar (2010). Regulation of Peptidoglycan Synthesis by Outer-Membrane Proteins. Cell, 143 (7), 1097-1109. doi: 10.1016/j.cell.2010.11.038

Book Chapter

Bacterial cell walls: peptidoglycan

Vollmer, W. (2024). Bacterial cell walls: peptidoglycan. Molecular medical microbiology. (pp. 45-67) edited by Yi-Wei Tang, Musa Hindiyeh, Dongyou Liu, Andrew Sails, Paul Spearman and Jingren Zhang. Cambridge, MA, United States: Academic Press. doi: 10.1016/b978-0-12-818619-0.00015-0
The cell wall of Streptococcus pneumoniae

Vollmer, Waldemar, Massidda, Orietta and Tomasz, Alexander (2019). The cell wall of Streptococcus pneumoniae. Gram-positive pathogens. (pp. 284-303) edited by Vincent A. Fischetti, Richard P. Novick, Joseph J. Ferretti, Daniel A. Portnoy, Miriam Braunstein and Julian I. Rood. Washington, DC United States: American Society for Microbiology. doi: 10.1128/9781683670131.ch18
Continuous Fluorescence Assay for Peptidoglycan Glycosyltransferases

Egan, Alexander J. F. and Vollmer, Waldemar (2016). Continuous Fluorescence Assay for Peptidoglycan Glycosyltransferases. Bacterial Cell Wall Homeostasis: Methods and Protocols. (pp. 171-184) edited by Hong, HJ. New York, NY United States: Humana Press. doi: 10.1007/978-1-4939-3676-2_13
The pneumococcal cell wall

Gisch, Nicolas, Peters, Katharina, Zähringer, Ulrich and Vollmer, Waldemar (2015). The pneumococcal cell wall. Streptococcus pneumoniae: molecular mechanisms of host-pathogen interactions . (pp. 145-167) edited by Jeremy Brown, Sven Hammerschmidt and Carlos Orihuela. Cambridge, MA United States: Academic Press. doi: 10.1016/b978-0-12-410530-0.00008-9
Peptidoglycan

Vollmer, Waldemar (2015). Peptidoglycan. Molecular medical microbiology. (pp. 105-124) edited by Yi-Wei Tang, Dongyou Liu, Max Sussman, Ian Poxton and Joseph Schwartzman. Cambridge, MA United States: Academic Press. doi: 10.1016/B978-0-12-397169-2.00006-8
Bacterial cell wall growth, shape and division

Derouaux, Adeline, Terrak, Mohammed, den Blaauwen, Tanneke and Vollmer, Waldemar (2014). Bacterial cell wall growth, shape and division. Bacterial membranes: structural and molecular biology. (pp. 3-54) edited by Han Remaut and Rémi Fronzes. Poole, United Kingdom: Caister Academic Press.
Murein peptide amidase MpaA

Vollmer, Waldemar (2013). Murein peptide amidase MpaA. Handbook of proteolytic enzymes. (pp. 1383-1385) edited by Neil D. Rawlings and Guy Salvesen. Amsterdam, Netherlands: Elsevier. doi: 10.1016/b978-0-12-382219-2.00310-0
Bacterial cell envelope peptidoglycan

Vollmer, Waldemar and Born, Petra (2010). Bacterial cell envelope peptidoglycan. Microbial glycobiology. (pp. 15-28) edited by Otto Holst, Patrick J. Brennan and Mark von Itzstein. Amsterdam, Netherlands: Elsevier. doi: 10.1016/b978-0-12-374546-0.00002-x
Preparation and analysis of pneumococcal murein (peptidoglycan)

Vollmer, W. (2007). Preparation and analysis of pneumococcal murein (peptidoglycan). Molecular Biology of Streptococci. (pp. 531-535) edited by Regine Hakenbeck and Singh Chhatwal. United Kingdom: Taylor & Francis.
Structure and biosynthesis of the pneumococcal cell wall

Vollmer, W. (2007). Structure and biosynthesis of the pneumococcal cell wall. Molecular Biology of Streptococci. (pp. 83-117) edited by Regine Hakenbeck and Singh Chhatwal. United Kingdom: Taylor & Francis.
Structure and Biosynthesis of the Murein (Peptidoglycan) Sacculus

Vollmer, Waldemar (2006). Structure and Biosynthesis of the Murein (Peptidoglycan) Sacculus. The Periplasm. (pp. 198-213) edited by Michael Ehrmann. Washington, DC United States: ASM Press. doi: 10.1128/9781555815806.ch11
Cytoskeletal elements in prokaryotes

Vollmer, Waldemar (2006). Cytoskeletal elements in prokaryotes. Complex intracellular structures in prokaryotes. (pp. 305-311) edited by Jessup M. Shively. Berlin, Heidelberg: Springer Berlin Heidelberg. doi: 10.1007/7171_029
Murein (Peptidoglycan)

Heidrich, C. and Vollmer, W. (2002). Murein (Peptidoglycan). Biopolymers, Polysaccharides I: Polysaccharides from Prokaryotes. (pp. 431-463) edited by Alexander Steinbüchel, Erick J. Vandamme, Martin Hofrichter and Sophie De Baets. Weinheim, Germany: Wiley.
A multienzyme complex involved in murein synthesis of Escherichia coli

von Rechenberg, M., Vollmer, W. and Höltje, J.V. (2001). A multienzyme complex involved in murein synthesis of Escherichia coli. Microbial fundamentals of biotechnology. (pp. 249-262) edited by Volkmar Braun and Friedrich Götz. Weinheim, Germany: Wiley.
Growth of the bacterial sacculus requires both polymerization and depolymerization of murein

Höltje, J.V., Schiffer, G., Vollmer, W. and von Rechenberg, M. (1998). Growth of the bacterial sacculus requires both polymerization and depolymerization of murein. Biochemical principles and mechanisms of biosynthesis and biodegradation of polymers. (pp. 68-76) edited by A. Steinbüchel. Münster, Germany: Wiley.

Journal Article

Reduced peptidoglycan synthesis capacity impairs growth of <i>E. coli</i> at high salt concentration

Alodaini, Dema, Hernandez-Rocamora, Victor, Boelter, Gabriela, Ma, Xuyu, Alao, Micheal B., Doherty, Hannah M., Bryant, Jack A., Moynihan, Patrick, Moradigaravand, Danesh, Glinkowska, Monika, Vollmer, Waldemar and Banzhaf, Manuel (2024). Reduced peptidoglycan synthesis capacity impairs growth of E. coli at high salt concentration. mBio. doi: 10.1128/mbio.00325-24
Peptidoglycan-Targeted [<sup>18</sup>F]3,3,3-Trifluoro-<scp>d</scp>-alanine Tracer for Imaging Bacterial Infection

Sorlin, Alexandre M., López-Álvarez, Marina, Biboy, Jacob, Gray, Joe, Rabbitt, Sarah J., Rahim, Junaid Ur, Lee, Sang Hee, Bobba, Kondapa Naidu, Blecha, Joseph, Parker, Mathew F.L., Flavell, Robert R., Engel, Joanne, Ohliger, Michael, Vollmer, Waldemar and Wilson, David M. (2024). Peptidoglycan-Targeted [18F]3,3,3-Trifluoro-d-alanine Tracer for Imaging Bacterial Infection. JACS Au, 4 (3), 1039-1047. doi: 10.1021/jacsau.3c00776
A dynamic bactofilin cytoskeleton cooperates with an M23 endopeptidase to control bacterial morphogenesis

Pöhl, Sebastian, Osorio-Valeriano, Manuel, Cserti, Emöke, Harberding, Jannik, Hernandez-Tamayo, Rogelio, Biboy, Jacob, Sobetzko, Patrick, Vollmer, Waldemar, Graumann, Peter L and Thanbichler, Martin (2024). A dynamic bactofilin cytoskeleton cooperates with an M23 endopeptidase to control bacterial morphogenesis. eLife, 12 ARTN RP86577. doi: 10.7554/elife.86577.3
A dynamic bactofilin cytoskeleton cooperates with an M23 endopeptidase to control bacterial morphogenesis

Pöhl, Sebastian, Osorio-Valeriano, Manuel, Cserti, Emöke, Harberding, Jannik, Hernandez-Tamayo, Rogelio, Biboy, Jacob, Sobetzko, Patrick, Vollmer, Waldemar, Graumann, Peter L. and Thanbichler, Martin (2024). A dynamic bactofilin cytoskeleton cooperates with an M23 endopeptidase to control bacterial morphogenesis. eLife, 13 RP86577. doi: 10.7554/eLife.86577
Real-time biosynthetic reaction monitoring informs the mechanism of action of antibiotics

Oluwole, Abraham O., Hernández-Rocamora, Víctor M., Cao, Yihui, Li, Xuechen, Vollmer, Waldemar, Robinson, Carol V. and Bolla, Jani R. (2024). Real-time biosynthetic reaction monitoring informs the mechanism of action of antibiotics. Journal of the American Chemical Society, 146 (10), 7007-7017. doi: 10.1021/jacs.4c00081
Structural basis for the hydrolytic activity of the transpeptidase-like protein DpaA to detach Braun’s lipoprotein from peptidoglycan

Wang, Hsiu-Jung, Hernández-Rocamora, Víctor M., Kuo, Chiao-I, Hsieh, Kan-Yen, Lee, Szu-Hui, Ho, Meng-Ru, Tu, Zhijay, Vollmer, Waldemar and Chang, Chung-I (2023). Structural basis for the hydrolytic activity of the transpeptidase-like protein DpaA to detach Braun’s lipoprotein from peptidoglycan. mBio, 14 (5) e01379, 1-11. doi: 10.1128/mbio.01379-23
NlpC/P60 peptidoglycan hydrolases of Trichomonas vaginalis have complementary activities that empower the protozoan to control host-protective lactobacilli

Barnett, Michael, Pinheiro, Jully P., Keown, Jeremy, Biboy, Jacob C., Gray, Joe J., Lucinescu, Ioana-Wilhelmina, Vollmer, Waldemar J., Hirt, Robert, Simoes-Barbosa, Augusto J. and Goldstone, David (2023). NlpC/P60 peptidoglycan hydrolases of Trichomonas vaginalis have complementary activities that empower the protozoan to control host-protective lactobacilli. PLoS Pathogens, 19 (8), e1011563. doi: 10.1371/journal.ppat.1011563
DipM controls multiple autolysins and mediates a regulatory feedback loop promoting cell constriction in Caulobacter crescentus

Izquierdo-Martinez, Adrian, Billini, Maria, Miguel-Ruano, Vega, Hernández-Tamayo, Rogelio, Richter, Pia, Biboy, Jacob, Batuecas, María T., Glatter, Timo, Vollmer, Waldemar, Graumann, Peter L., Hermoso, Juan A. and Thanbichler, Martin (2023). DipM controls multiple autolysins and mediates a regulatory feedback loop promoting cell constriction in Caulobacter crescentus. Nature Communications, 14 (1) 4095, 4095. doi: 10.1038/s41467-023-39783-w
Deciphering the adaption of bacterial cell wall mechanical integrity and turgor to different chemical or mechanical environments

Han, Rui, Feng, Xi-Qiao, Vollmer, Waldemar, Stoodley, Paul and Chen, Jinju (2023). Deciphering the adaption of bacterial cell wall mechanical integrity and turgor to different chemical or mechanical environments. Journal of Colloid and Interface Science, 640, 510-520. doi: 10.1016/j.jcis.2023.02.100
Multiple Campylobacter jejuni proteins affecting the peptidoglycan structure and the degree of helical cell curvature

Frirdich, Emilisa, Vermeulen, Jenny, Biboy, Jacob, Vollmer, Waldemar and Gaynor, Erin C. (2023). Multiple Campylobacter jejuni proteins affecting the peptidoglycan structure and the degree of helical cell curvature. Frontiers in Microbiology, 14. doi: 10.3389/fmicb.2023.1162806
An NlpC/P60 protein catalyzes a key step in peptidoglycan recycling at the intersection of energy recovery, cell division and immune evasion in the intracellular pathogen Chlamydia trachomatis

Reuter, Jula, Otten, Christian, Jacquier, Nicolas, Lee, Junghoon, Mengin-Lecreulx, Dominique, Löckener, Iris, Kluj, Robert, Mayer, Christoph, Corona, Federico, Dannenberg, Julia, Aeby, Sébastien, Bühl, Henrike, Greub, Gilbert, Vollmer, Waldemar, Ouellette, Scot P., Schneider, Tanja and Henrichfreise, Beate (2023). An NlpC/P60 protein catalyzes a key step in peptidoglycan recycling at the intersection of energy recovery, cell division and immune evasion in the intracellular pathogen Chlamydia trachomatis. PLoS Pathogens, 19 (2) e1011047, 1-29. doi: 10.1371/journal.ppat.1011047
Outer membrane-anchoring enables LpoB to regulate peptidoglycan synthesis rate

Kermani, Ali A, Biboy, Jacob, Vollmer, Daniela and Vollmer, Waldemar (2022). Outer membrane-anchoring enables LpoB to regulate peptidoglycan synthesis rate. The Cell Surface, 8 100086, 1-9. doi: 10.1016/j.tcsw.2022.100086
Molecular characterization of the type VI secretion system effector Tlde1a reveals a structurally altered fold

Cobo, Neil Lorente, Sibinelli-Sousa, Stephanie, Biboy, Jacob, Vollmer, Waldemar, Bayer-Santos, Ethel and Prehna, Gerd (2022). Molecular characterization of the type VI secretion system effector Tlde1a reveals a structurally altered fold. Journal of Biological Chemistry, 298 (11) 102556, 1-17. doi: 10.1016/j.jbc.2022.102556
Simultaneous determination of the mechanical properties and turgor of a single bacterial cell using atomic force microscopy

Han, Rui, Vollmer, Waldemar, Perry, John D., Stoodley, Paul and Chen, Jinju (2022). Simultaneous determination of the mechanical properties and turgor of a single bacterial cell using atomic force microscopy. Nanoscale, 14 (33), 12060-12068. doi: 10.1039/d2nr02577a
Peptidoglycan from Akkermansia muciniphila Muc(T): chemical structure and immunostimulatory properties of muropeptides

Garcia-Vello, Pilar, Tytgat, Hanne L. P., Gray, Joe, Elzinga, Janneke, Di Lorenzo, Flaviana, Biboy, Jacob, Vollmer, Daniela, De Castro, Cristina, Vollmer, Waldemar, de Vos, Willem M. and Molinaro, Antonio (2022). Peptidoglycan from Akkermansia muciniphila Muc(T): chemical structure and immunostimulatory properties of muropeptides. Glycobiology, 32 (8), 712-719. doi: 10.1093/glycob/cwac027
Metabolic labeling of the bacterial peptidoglycan by functionalized glucosamine

Xu, Yang, Hernandez-Rocamora, Victor M., Lorent, Joseph H., Cox, Ruud, Wang, Xiaoqi, Bao, Xue, Stel, Marjon, Vos, Gael, van den Bos, Ramon M., Pieters, Roland J., Gray, Joe, Vollmer, Waldemar and Breukink, Eefjan (2022). Metabolic labeling of the bacterial peptidoglycan by functionalized glucosamine. iScience, 25 (8) 104753, 1-19. doi: 10.1016/j.isci.2022.104753
Antibacterial potency of type VI amidase effector toxins is dependent on substrate topology and cellular context

Radkov, Atanas, Sapiro, Anne L., Flores, Sebastian, Henderson, Corey, Saunders, Hayden, Kim, Rachel, Massa, Steven, Thompson, Samuel, Mateusiak, Chase, Biboy, Jacob, Zhao, Ziyi, Starita, Lea M., Hatleberg, William L., Vollmer, Waldemar, Russell, Alistair B., Simorre, Jean-Pierre, Anthony-Cahill, Spencer, Brzovic, Peter, Hayes, Beth and Chou, Seemay (2022). Antibacterial potency of type VI amidase effector toxins is dependent on substrate topology and cellular context. eLife, 11, 1-26. doi: 10.7554/eLife.79796
Penicillin-binding protein 1 (PBP1) of Staphylococcus aureus has multiple essential functions in cell division

Wacnik, Katarzyna, Rao, Vincenzo A., Chen, Xinyue, Lafage, Lucia, Pazos, Manuel, Booth, Simon, Vollmer, Waldemar, Hobbs, Jamie K., Lewis, Richard J. and Foster, Simon J. (2022). Penicillin-binding protein 1 (PBP1) of Staphylococcus aureus has multiple essential functions in cell division. mBio, 13 (4), 1-19. doi: 10.1128/mbio.00669-22
Peptidoglycan maturation controls outer membrane protein assembly

Mamou, Gideon, Corona, Federico, Cohen-Khait, Ruth, Housden, Nicholas G., Yeung, Vivian, Sun, Dawei, Sridhar, Pooja, Pazos, Manuel, Knowles, Timothy J., Kleanthous, Colin and Vollmer, Waldemar (2022). Peptidoglycan maturation controls outer membrane protein assembly. Nature, 606 (7916), 953-959. doi: 10.1038/s41586-022-04834-7
Peptidoglycan recycling promotes outer membrane integrity and carbapenem tolerance in Acinetobacter baumannii

Islam, Nowrosh, Kazi, Misha, Kang, Katie N., Biboy, Jacob, Gray, Joe, Ahmed, Feroz, Schargel, Richard D., Boutte, Cara C., Dorr, Tobias, Vollmer, Waldemar and Boll, Joseph M. (2022). Peptidoglycan recycling promotes outer membrane integrity and carbapenem tolerance in Acinetobacter baumannii. mBio, 13 (3), 1-19. doi: 10.1128/mbio.01001-22
Early midcell localization of Escherichia coli PBP4 supports the function of peptidoglycan amidases

Verheul, Jolanda, Lodge, Adam, Yau, Hamish C. L., Liu, Xiaolong, Boelter, Gabriela, Liu, Xinwei, Solovyova, Alexandra S., Typas, Athanasios, Banzhaf, Manuel, Vollmer, Waldemar and den Blaauwen, Tanneke (2022). Early midcell localization of Escherichia coli PBP4 supports the function of peptidoglycan amidases. PLoS Genetics, 18 (5), 1-36. doi: 10.1371/journal.pgen.1010222
Peptidoglycan biosynthesis is driven by lipid transfer along enzyme-substrate affinity gradients

Oluwole, Abraham O., Corey, Robin A., Brown, Chelsea M., Hernandez-Rocamora, Victor M., Stansfeld, Phillip J., Vollmer, Waldemar, Bolla, Jani R. and Robinson, Carol (2022). Peptidoglycan biosynthesis is driven by lipid transfer along enzyme-substrate affinity gradients. Nature Communications, 13 (1) 2278, 1-12. doi: 10.1038/s41467-022-29836-x
Asymmetric peptidoglycan editing generates cell curvature in Bdellovibrio predatory bacteria

Banks, Emma J., Valdivia-Delgado, Mauricio, Biboy, Jacob, Wilson, Amber, Cadby, Ian T., Vollmer, Waldemar, Lambert, Carey, Lovering, Andrew L. and Sockett, R. Elizabeth (2022). Asymmetric peptidoglycan editing generates cell curvature in Bdellovibrio predatory bacteria. Nature Communications, 13 (1) 1509, 1-15. doi: 10.1038/s41467-022-29007-y
The VarA-CsrA regulatory pathway influences cell shape in Vibrio cholerae

Rocha, Leonardo F. Lemos, Peters, Katharina, Biboy, Jacob, Depelteau, Jamie S., Briegel, Ariane, Vollmer, Waldemar and Blokesch, Melanie (2022). The VarA-CsrA regulatory pathway influences cell shape in Vibrio cholerae. PLoS Genetics, 18 (3), 1-24. doi: 10.1371/journal.pgen.1010143
Slippery liquid-like solid surfaces with promising antibiofilm performance under both static and flow conditions

Zhu, Yufeng, McHale, Glen, Dawson, Jack, Armstrong, Steven, Wells, Gary, Han, Rui, Liu, Hongzhong, Vollmer, Waldemar, Stoodley, Paul, Jakubovics, Nicholas and Chen, Jinju (2022). Slippery liquid-like solid surfaces with promising antibiofilm performance under both static and flow conditions. ACS Applied Materials and Interfaces, 14 (5), 6307-6319. doi: 10.1021/acsami.1c14533
Commensal Streptococcus mitis produces two different lipoteichoic acids of type I and type IV

Gisch, Nicolas, Peters, Katharina, Thomsen, Simone, Vollmer, Waldemar, Schwudke, Dominik and Denapaite, Dalia (2021). Commensal Streptococcus mitis produces two different lipoteichoic acids of type I and type IV. Glycobiology, 31 (12), 1655-1669. doi: 10.1093/glycob/cwab079
Loss of YhcB results in dysregulation of coordinated peptidoglycan, LPS and phospholipid synthesis during Escherichia coli cell growth

Goodall, Emily C. A., Isom, Georgia L., Rooke, Jessica L., Pullela, Karthik, Icke, Christopher, Yang, Zihao, Boelter, Gabriela, Jones, Alun, Warner, Isabel, Da Costa, Rochelle, Zhang, Bing, Rae, James, Tan, Wee Boon, Winkle, Matthias, Delhaye, Antoine, Heinz, Eva, Collet, Jean-Francois, Cunningham, Adam F., Blaskovich, Mark A., Parton, Robert G., Cole, Jeff A., Banzhaf, Manuel, Chng, Shu-Sin, Vollmer, Waldemar, Bryant, Jack A. and Henderson, Ian R. (2021). Loss of YhcB results in dysregulation of coordinated peptidoglycan, LPS and phospholipid synthesis during Escherichia coli cell growth. PLoS Genetics, 17 (12) e1009586, 1-40. doi: 10.1371/journal.pgen.1009586
Lytic transglycosylase MltG cleaves in nascent peptidoglycan and produces short glycan strands

Sassine, Jad, Pazos, Manuel, Breukink, Eefjan and Vollmer, Waldemar (2021). Lytic transglycosylase MltG cleaves in nascent peptidoglycan and produces short glycan strands. The Cell Surface, 7 100053, 1-9. doi: 10.1016/j.tcsw.2021.100053
Role of endopeptidases in peptidoglycan synthesis mediated by alternative cross-linking enzymes in Escherichia coli

Voedts, Henri, Dorchene, Delphine, Lodge, Adam, Vollmer, Waldemar, Arthur, Michel and Hugonnet, Jean-Emmanuel (2021). Role of endopeptidases in peptidoglycan synthesis mediated by alternative cross-linking enzymes in Escherichia coli. The EMBO Journal, 40 (19) e108126, 1-19. doi: 10.15252/embj.2021108126
Combining cell envelope stress reporter assays in a screening approach to identify BAM complex inhibitors

Steenhuis, Maurice, Corona, Federico, Ten Hagen-Jongman, Corinne M., Vollmer, Waldemar, Lambin, Dominique, Selhorst, Philippe, Klaassen, Hugo, Versele, Matthias, Chaltin, Patrick and Luirink, Joen (2021). Combining cell envelope stress reporter assays in a screening approach to identify BAM complex inhibitors. ACS Infectious Diseases, 7 (8), 2250-2263. doi: 10.1021/acsinfecdis.0c00728
DpaA detaches Braun’s lipoprotein from peptidoglycan

Winkle, Matthias, Hernández-Rocamora, Víctor M., Pullela, Karthik, Goodall, Emily C. A., Martorana, Alessandra M., Gray, Joe, Henderson, Ian R., Polissi, Alessandra and Vollmer, Waldemar (2021). DpaA detaches Braun’s lipoprotein from peptidoglycan. mBio, 12 (3) e00836-21. doi: 10.1128/mbio.00836-21
Discovery of Pyrrolidine-2,3-diones as novel inhibitors of P. aeruginosa PBP3

Lopez-Perez, Arancha, Freischem, Stefan, Grimm, Immanuel, Weiergraeber, Oliver, Dingley, Andrew J., Lopez-Alberca, Maria Pascual, Waldmann, Herbert, Vollmer, Waldemar, Kumar, Kamal and Vuong, Cuong (2021). Discovery of Pyrrolidine-2,3-diones as novel inhibitors of P. aeruginosa PBP3. Antibiotics, 10 (5), 1-18. doi: 10.3390/antibiotics10050529
The active repertoire of Escherichia coli peptidoglycan amidases varies with physiochemical environment

Mueller, Elizabeth A., Iken, Abbygail G., Oeztuerk, Mehmet Ali, Winkle, Matthias, Schmitz, Mirko, Vollmer, Waldemar, Di Ventura, Barbara and Levin, Petra Anne (2021). The active repertoire of Escherichia coli peptidoglycan amidases varies with physiochemical environment. Molecular Microbiology, 116 (1) mmi.14711, 311-328. doi: 10.1111/mmi.14711
Localizing peptidoglycan synthesis in Helicobacter pylori using vlickable metabolic probes

Taylor, Jennifer A., Santiago, Cintia C., Gray, Joe, Wodzanowski, Kimberly A., DeMeester, Kristen E., Biboy, Jacob, Vollmer, Waldemar, Grimes, Catherine L. and Salama, Nina R. (2021). Localizing peptidoglycan synthesis in Helicobacter pylori using vlickable metabolic probes. Current Protocols, 1 (4) e80, 1-52. doi: 10.1002/cpz1.80
Regulation and function of class A Penicillin-binding proteins

Pazos, Manuel and Vollmer, Waldemar (2021). Regulation and function of class A Penicillin-binding proteins. Current Opinion in Microbiology, 60, 80-87. doi: 10.1016/j.mib.2021.01.008
Staphylococcus aureus cell wall structure and dynamics during host-pathogen interaction

Sutton, Joshua A. F., Carnell, Oliver T., Lafage, Lucia, Gray, Joe, Biboy, Jacob, Gibson, Josie F., Pollitt, Eric J. G., Tazoll, Simone C., Turnbull, William, Hajdamowicz, Natalia H., Salamaga, Bartlomiej, Pidwill, Grace R., Condliffe, Alison M., Renshaw, Stephen A., Vollmer, Waldemar and Foster, Simon J. (2021). Staphylococcus aureus cell wall structure and dynamics during host-pathogen interaction. PLoS Pathogens, 17 (3), e1009468. doi: 10.1371/journal.ppat.1009468
ActS activates peptidoglycan amidases during outer membrane stress in Escherichia coli

Serrano, Carlos K. Gurnani, Winkle, Matthias, Martorana, Alessandra M., Biboy, Jacob, More, Niccolo, Moynihan, Patrick, Banzhaf, Manuel, Vollmer, Waldemar and Polissi, Alessandra (2021). ActS activates peptidoglycan amidases during outer membrane stress in Escherichia coli. Molecular Microbiology, 116 (1), 329-342. doi: 10.1111/mmi.14712
The novel membrane-associated auxiliary factors AuxA and AuxB modulate β-lactam resistance in MRSA by stabilizing lipoteichoic acids

Mikkelsen, Kasper, Sirisarn, Wanchat, Alharbi, Ohood, Alharbi, Mohanned, Liu, Huayong, Nohr-Meldgaard, Katrine, Mayer, Katharina, Vestergaard, Martin, Gallagher, Laura A., Derrick, Jeremy P., McBain, Andrew J., Biboy, Jacob, Vollmer, Waldemar, O'Gara, James P., Grunert, Tom, Ingmer, Hanne and Xia, Guoqing (2021). The novel membrane-associated auxiliary factors AuxA and AuxB modulate β-lactam resistance in MRSA by stabilizing lipoteichoic acids. International Journal of Antimicrobial Agents, 57 (3) 106283, 1-9. doi: 10.1016/j.ijantimicag.2021.106283
Real-time monitoring of peptidoglycan synthesis by membrane-reconstituted penicillin-binding proteins

Hernandez-Rocamora, Victor M., Baranova, Natalia, Peters, Katharina, Breukink, Eefjan, Loose, Martin and Vollmer, Waldemar (2021). Real-time monitoring of peptidoglycan synthesis by membrane-reconstituted penicillin-binding proteins. eLife, 10, 1-32. doi: 10.7554/eLife.61525
Septal class A penicillin-binding protein activity and LD-transpeptidases mediate selection of colistin-resistant lipooligosaccharide-deficient Acinetobacter baumannii

Kang, Katie N., Kazi, Misha I., Biboy, Jacob, Gray, Joe, Bovermann, Hannah, Ausman, Jessie, Boutte, Cara C., Vollmer, Waldemar and Boll, Joseph M. (2021). Septal class A penicillin-binding protein activity and LD-transpeptidases mediate selection of colistin-resistant lipooligosaccharide-deficient Acinetobacter baumannii. mBio, 12 (1), 1-16. doi: 10.1128/mBio.02185-20
Ticks resist skin commensals with immune factor of bacterial origin

Hayes, Beth M., Radkov, Atanas D., Yarza, Fauna, Flores, Sebastian, Kim, Jungyun, Zhao, Ziyi, Lexa, Katrina W., Marnin, Liron, Biboy, Jacob, Bowcut, Victoria, Vollmer, Waldemar, Pedra, Joao H. F. and Chou, Seemay (2020). Ticks resist skin commensals with immune factor of bacterial origin. Cell, 183 (6), 1562-1571.e12. doi: 10.1016/j.cell.2020.10.042
MreC and MreD balance the interaction between the elongasome proteins PBP2 and RodA

Liu, Xiaolong, Biboy, Jacob, Consoli, Elisa, Vollmer, Waldemar and den Blaauwen, Tanneke (2020). MreC and MreD balance the interaction between the elongasome proteins PBP2 and RodA. PLoS Genetics, 16 (12), 1-23. doi: 10.1371/journal.pgen.1009276
SPOR proteins are required for functionality of class a penicillin-binding proteins in Escherichia coli

Pazos, Manuel, Peters, Katharina, Boes, Adrien, Safaei, Yalda, Kenward, Calem, Caveney, Nathanael A., Laguri, Cedric, Breukink, Eefjan, Strynadka, Natalie C. J., Simorre, Jean-Pierre, Terrak, Mohammed and Vollmer, Waldemar (2020). SPOR proteins are required for functionality of class a penicillin-binding proteins in Escherichia coli. mBio, 11 (6), 1-16. doi: 10.1128/mBio.02796-20
Cell morphology maintenance in Bacillus subtilis through balanced peptidoglycan synthesis and hydrolysis

Sassine, Jad, Sousa, Joana, Lalk, Michael, Daniel, Richard A. and Vollmer, Waldemar (2020). Cell morphology maintenance in Bacillus subtilis through balanced peptidoglycan synthesis and hydrolysis. Scientific Reports, 10 (1), 1-14. doi: 10.1038/s41598-020-74609-5
Peptidoglycan editing provides immunity to Acinetobacter baumannii during bacterial warfare

Le, Nguyen-Hung, Peters, Katharina, Espaillat, Akbar, Sheldon, Jessica R., Gray, Joe, Di Venanzio, Gisela, Lopez, Juvenal, Djahanschiri, Bardya, Mueller, Elizabeth A., Hennon, Seth W., Levin, Petra Anne, Ebersberger, Ingo, Skaar, Eric P., Cava, Felipe, Vollmer, Waldemar and Feldman, Mario F. (2020). Peptidoglycan editing provides immunity to Acinetobacter baumannii during bacterial warfare. Science Advances, 6 (30), 1-8. doi: 10.1126/sciadv.abb5614
Structure of the peptidoglycan synthase activator LpoP in Pseudomonas aeruginosa

Caveney, Nathanael A., Egan, Alexander J. F., Ayala, Isabel, Laguri, Cedric, Robb, Craig S., Breukink, Eefjan, Vollmer, Waldemar, Strynadka, Natalie C. J. and Simorre, Jean-Pierre (2020). Structure of the peptidoglycan synthase activator LpoP in Pseudomonas aeruginosa. Structure, 28 (6), 643-650.e5. doi: 10.1016/j.str.2020.03.012
Regulation of peptidoglycan synthesis and remodelling

Egan, Alexander J. F., Errington, Jeff and Vollmer, Waldemar (2020). Regulation of peptidoglycan synthesis and remodelling. Nature Reviews. Microbiology, 18 (8), 446-460. doi: 10.1038/s41579-020-0366-3
Tol-Pal system and Rgs proteins interact to promote unipolar growth and cell division in Sinorhizobium meliloti

Krol, Elizaveta, Yau, Hamish C. L., Lechner, Marcus, Schaeper, Simon, Bange, Gert, Vollmer, Waldemar and Becker, Anke (2020). Tol-Pal system and Rgs proteins interact to promote unipolar growth and cell division in Sinorhizobium meliloti. mBio, 11 (3), 1-21. doi: 10.1128/mBio.00306-20
Outer membrane lipoprotein NlpI scaffolds peptidoglycan hydrolases within multi-enzyme complexes in Escherichia coli

Banzhaf, Manuel, Yau, Hamish C. L., Verheul, Jolanda, Lodge, Adam, Kritikos, George, Mateus, Andre, Cordier, Baptiste, Hov, Ann Kristin, Stein, Frank, Wartel, Morgane, Pazos, Manuel, Solovyova, Alexandra S., Breukink, Eefjan, van Teeffelen, Sven, Savitski, Mikhail M., den Blaauwen, Tanneke, Typas, Athanasios and Vollmer, Waldemar (2020). Outer membrane lipoprotein NlpI scaffolds peptidoglycan hydrolases within multi-enzyme complexes in Escherichia coli. The EMBO Journal, 39 (5) e102246, 1-20. doi: 10.15252/embj.2019102246
Diffusion and capture permits dynamic coupling between treadmilling FtsZ filaments and cell division proteins

Baranova, Natalia, Radler, Philipp, Hernandez-Rocamora, Victor M., Alfonso, Carlos, Lopez-Pelegrin, Mar, Rivas, German, Vollmer, Waldemar and Loose, Martin (2020). Diffusion and capture permits dynamic coupling between treadmilling FtsZ filaments and cell division proteins. Nature Microbiology, 5 (3), 407-417. doi: 10.1038/s41564-019-0657-5
Distinct cytoskeletal proteins define zones of enhanced cell wall synthesis in Helicobacter pylori

Taylor, Jennifer A., Bratton, Benjamin P., Sichel, Sophie R., Blair, Kris M., Jacobs, Holly M., DeMeester, Kristen E., Kuru, Erkin, Gray, Joe, Biboy, Jacob, VanNieuwenhze, Michael S., Vollmer, Waldemar, Grimes, Catherine L., Shaevitz, Joshua W. and Salama, Nina R. (2020). Distinct cytoskeletal proteins define zones of enhanced cell wall synthesis in Helicobacter pylori. eLife, 9, 1-38. doi: 10.7554/eLife.52482
Mechanisms of incorporation for D-amino acid probes that target peptidoglycan biosynthesis

Kuru, Erkin, Radkov, Atanas, Meng, Xin, Egan, Alexander, Alvarez, Laura, Dowson, Amanda, Booher, Garrett, Breukink, Eefjan, Roper, David I., Cava, Felipe, Vollmer, Waldemar, Brun, Yves and VanNieuwenhze, Michael S. (2019). Mechanisms of incorporation for D-amino acid probes that target peptidoglycan biosynthesis. ACS Chemical Biology, 14 (12), 2745-2756. doi: 10.1021/acschembio.9b00664
The Pseudomonas aeruginosa T6SS delivers a periplasmic toxin that disrupts bacterial cell morphology

Wood, Thomas E., Howard, Sophie A., Forster, Andreas, Nolan, Laura M., Manoli, Eleni, Bullen, Nathan P., Yau, Hamish C. L., Hachani, Abderrahman, Hayward, Richard D., Whitney, John C., Vollmer, Waldemar, Freemont, Paul S. and Filloux, Alain (2019). The Pseudomonas aeruginosa T6SS delivers a periplasmic toxin that disrupts bacterial cell morphology. Cell Reports, 29 (1), 187-201.e7. doi: 10.1016/j.celrep.2019.08.094
Cell wall peptidoglycan in Mycobacterium tuberculosis: an Achilles' heel for the TB-causing pathogen

Maitra, Arundhati, Munshi, Tulika, Healy, Jess, Martin, Liam T., Vollmer, Waldemar, Keep, Nicholas H. and Bhakta, Sanjib (2019). Cell wall peptidoglycan in Mycobacterium tuberculosis: an Achilles' heel for the TB-causing pathogen. Fems Microbiology Reviews, 43 (5), 548-575. doi: 10.1093/femsre/fuz016
D-amino acid derivatives as in situ probes for visualizing bacterial peptidoglycan biosynthesis

Hsu, Yen-Pang, Booher, Garrett, Egan, Alexander, Vollmer, Waldemar and VanNieuwenhze, Michael S. (2019). D-amino acid derivatives as in situ probes for visualizing bacterial peptidoglycan biosynthesis. Accounts of Chemical Research, 52 (9), 2713-2722. doi: 10.1021/acs.accounts.9b00311
Does the nucleoid determine cell dimensions in Escherichia coli?

Zaritsky, Arieh, Vollmer, Waldemar, Mannik, Jaan and Liu, Chenli (2019). Does the nucleoid determine cell dimensions in Escherichia coli?. Frontiers in Microbiology, 10, 1-7. doi: 10.3389/fmicb.2019.01717
Optimized protocol for the incorporation of FDAA (HADA labeling) for in situ labeling of peptidoglycan

Peters, Katharina, Pazos, Manuel, VanNieuwenhze, Michael S. and Vollmer, Waldemar (2019). Optimized protocol for the incorporation of FDAA (HADA labeling) for in situ labeling of peptidoglycan. Bio-protocol, 9 (15), 1-12. doi: 10.21769/BioProtoc.3316
Borrelia burgdorferi peptidoglycan is a persistent antigen in patients with Lyme arthritis

Jutras, Brandon L., Lochhead, Robert B., Kloos, Zachary A., Biboy, Jacob, Strle, Klemen, Booth, Carmen J., Govers, Sander K., Gray, Joe, Schumann, Peter, Vollmer, Waldemar, Bockenstedt, Linda K., Steere, Allen C. and Jacobs-Wagner, Christine (2019). Borrelia burgdorferi peptidoglycan is a persistent antigen in patients with Lyme arthritis. Proceedings of the National Academy of Sciences of the United States of America, 116 (27), 13498-13507. doi: 10.1073/pnas.1904170116
A genome-wide Helicobacter pylori morphology screen uncovers a membrane-spanning helical cell shape complex

Yang, Desiree C., Blair, Kris M., Taylor, Jennifer A., Petersen, Timothy W., Sessler, Tate, Tull, Christina M., Leverich, Christina K., Collar, Amanda L., Wyckoff, Timna J., Biboy, Jacob, Vollmer, Waldemar and Salama, Nina R. (2019). A genome-wide Helicobacter pylori morphology screen uncovers a membrane-spanning helical cell shape complex. Journal of Bacteriology, 201 (14), 1-16. doi: 10.1128/JB.00724-18
The Campylobacter jejuni helical to coccoid transition involves changes to peptidoglycan and the ability to elicit an immune response

Frirdich, Emilisa, Biboy, Jacob, Pryjma, Mark, Lee, Jooeun, Huynh, Steven, Parker, Craig T., Girardin, Stephen E., Vollmer, Waldemar and Gaynor, Erin C. (2019). The Campylobacter jejuni helical to coccoid transition involves changes to peptidoglycan and the ability to elicit an immune response. Molecular Microbiology, 112 (1), 280-301. doi: 10.1111/mmi.14269
The cell wall of Streptococcus pneumoniae

Vollmer, Waldemar, Massidda, Orietta and Tomasz, Alexander (2019). The cell wall of Streptococcus pneumoniae. Microbiology Spectrum, 7 (3), 1-25. doi: 10.1128/microbiolspec.GPP3-0018-2018
Plasticity of Escherichia coli cell wall metabolism promotes fitness and antibiotic resistance across environmental conditions

Mueller, Elizabeth A., Egan, Alexander J. F., Breukink, Eefjan, Vollmer, Waldemar and Levin, Petra Anne (2019). Plasticity of Escherichia coli cell wall metabolism promotes fitness and antibiotic resistance across environmental conditions. eLife, 8, 1-24. doi: 10.7554/eLife.40754
Studying intact bacterial peptidoglycan by proton-detected NMR spectroscopy at 100 kHz MAS frequency

Bougault, Catherine, Ayala, Isabel, Vollmer, Waldemar, Simorre, Jean-Pierre and Schanda, Paul (2019). Studying intact bacterial peptidoglycan by proton-detected NMR spectroscopy at 100 kHz MAS frequency. Journal of Structural Biology, 206 (1), 66-72. doi: 10.1016/j.jsb.2018.07.009
Coordination of capsule assembly and cell wall biosynthesis in Staphylococcus aureus

Rausch, Marvin, Deisinger, Julia P., Ulm, Hannah, Mueller, Anna, Li, Wenjin, Hardt, Patrick, Wang, Xiaogang, Li, Xue, Sylvester, Marc, Engeser, Marianne, Vollmer, Waldemar, Mueller, Christa E., Sahl, Hans Georg, Lee, Jean Claire and Schneider, Tanja (2019). Coordination of capsule assembly and cell wall biosynthesis in Staphylococcus aureus. Nature Communications, 10 (1) 1404, 1404. doi: 10.1038/s41467-019-09356-x
A specialized MreB-dependent cell wall biosynthetic complex mediates the formation of stalk-specific peptidoglycan in Caulobacter crescentus

Billini, Maria, Biboy, Jacob, Kuehn, Juliane, Vollmer, Waldemar and Thanbichler, Martin (2019). A specialized MreB-dependent cell wall biosynthetic complex mediates the formation of stalk-specific peptidoglycan in Caulobacter crescentus. Plos Genetics, 15 (2), 1-33. doi: 10.1371/journal.pgen.1007897
Recognition of peptidoglycan fragments by the transpeptidase PBP4 From Staphylococcus aureus

Maya-Martine, Roberto, Alexander, J. Andrew N., Otten, Christian F., Ayala, Isabel, Vollmer, Daniela, Gray, Joe, Bougault, Catherine M., Burt, Alister, Laguri, Cedric, Fonvielles, Matthieu, Arthur, Michel, Strynadka, Natalie C. J., Vollmer, Waldemar and Simorre, Jean-Pierre (2019). Recognition of peptidoglycan fragments by the transpeptidase PBP4 From Staphylococcus aureus. Frontiers in Microbiology, 9, 1-14. doi: 10.3389/fmicb.2018.03223
Peptidoglycan Remodeling Enables Escherichia coli To Survive Severe Outer Membrane Assembly Defect

More, Niccolo, Martorana, Alessandra M., Biboy, Jacob, Otten, Christian, Winkle, Matthias, Serrano, Carlos K. Gurnani, Silva, Alejandro Monton, Atkinson, Lisa, Yau, Hamish, Breukink, Eefjan, den Blaauwen, Tanneke, Vollmer, Waldemar and Polissi, Alessandra (2019). Peptidoglycan Remodeling Enables Escherichia coli To Survive Severe Outer Membrane Assembly Defect. Mbio, 10 (1). doi: 10.1128/mBio.02729-18
Role of the putative polysaccharide deacetylase BA1836 from B. anthracis in spore development and germination

Tomatsidou, Anastasia, Koutsioulis, Dimitris, Tzamarias, Dimitris, Kokkinidis, Michael, Vollmer, Waldemar and Bouriotis, Vassilis (2019). Role of the putative polysaccharide deacetylase BA1836 from B. anthracis in spore development and germination. Advances in Microbiology, 09 (08), 679-702. doi: 10.4236/aim.2019.98042
The protozoan Trichomonas vaginalis targets bacteria with laterally acquired NlpC/P60 peptidoglycan hydrolases

Pinheiro, Jully, Biboy, Jacob, Vollmer, Waldemar, Hirt, Robert P., Keown, Jeremy R., Artuyants, Anastasiia, Black, Moyra M., Goldstone, David C. and Simoes-Barbosa, Augusto (2018). The protozoan Trichomonas vaginalis targets bacteria with laterally acquired NlpC/P60 peptidoglycan hydrolases. mBio, 9 (6), 1-17. doi: 10.1128/mBio.01784-18
Inactivation of the monofunctional peptidoglycan glycosyltransferase SgtB allows Staphylococcus aureus to survive in the absence of lipoteichoic acid

Karinou, Eleni, Schuster, Christopher F., Pazos, Manuel, Vollmer, Waldemar and Grundling, Angelika (2018). Inactivation of the monofunctional peptidoglycan glycosyltransferase SgtB allows Staphylococcus aureus to survive in the absence of lipoteichoic acid. Journal of Bacteriology, 201 (1), 1-18. doi: 10.1128/JB.00574-18
Z-ring membrane anchors associate with cell wall synthases to initiate bacterial cell division

Pazos, Manuel, Peters, Katharina, Casanova, Mercedes, Palacios, Pilar, VanNieuwenhze, Michael, Breukink, Eefjan, Vicente, Miguel and Vollmer, Waldemar (2018). Z-ring membrane anchors associate with cell wall synthases to initiate bacterial cell division. Nature Communications, 9 (1) 5090. doi: 10.1038/s41467-018-07559-2
Induced conformational changes activate the peptidoglycan synthase PBP1B

Egan, Alexander J. F., Maya-Martinez, Roberto, Ayala, Isabel, Bougault, Catherine M., Banzhaf, Manuel, Breukink, Eefjan, Vollmer, Waldemar and Simorre, Jean-Pierre (2018). Induced conformational changes activate the peptidoglycan synthase PBP1B. Molecular Microbiology, 110 (3), 335-356. doi: 10.1111/mmi.14082
Peptidoglycan degradation machinery in Clostridium difficile forespore engulfment

Dembek, Marcin, Kelly, Abigail, Barwinska-Sendra, Anna, Tarrant, Emma, Stanley, Will A., Vollmer, Daniela, Biboy, Jacob, Gray, Joe, Vollmer, Waldemar and Salgado, Paula S. (2018). Peptidoglycan degradation machinery in Clostridium difficile forespore engulfment. Molecular Microbiology, 110 (3), 390-410. doi: 10.1111/mmi.14091
Peptidoglycan editing by a specific LD-transpeptidase controls the muramidase-dependent secretion of typhoid toxin

Geiger, Tobias, Pazos, Manuel, Lara-Tejero, Maria, Vollmer, Waldemar and Galan, Jorge E. (2018). Peptidoglycan editing by a specific LD-transpeptidase controls the muramidase-dependent secretion of typhoid toxin. Nature Microbiology, 3 (11), 1243-1254. doi: 10.1038/s41564-018-0248-x
Molecular basis for immunity protein recognition of a type VII secretion system exported antibacterial toxin

Klein, Timothy A., Pazos, Manuel, Surette, Michael G., Vollmer, Waldemar and Whitney, John C. (2018). Molecular basis for immunity protein recognition of a type VII secretion system exported antibacterial toxin. Journal of Molecular Biology, 430 (21), 4344-4358. doi: 10.1016/j.jmb.2018.08.027
Copper inhibits peptidoglycan LD-transpeptidases suppressing beta-lactam resistance due to bypass of penicillin-binding proteins

Peters, Katharina, Pazos, Manuel, Edoo, Zainab, Hugonnet, Jean-Emmanuel, Martorana, Alessandra M., Polissi, Alessandra, VanNieuwenhze, Michael S., Arthur, Michel and Vollmer, Waldemar (2018). Copper inhibits peptidoglycan LD-transpeptidases suppressing beta-lactam resistance due to bypass of penicillin-binding proteins. Proceedings of the National Academy of Sciences of the United States of America, 115 (42), 10786-10791. doi: 10.1073/pnas.1809285115
Two Faces of CwIM, an Essential PknB Substrate, in Mycobacterium tuberculosis

Turapov, Obolbek, Forti, Francesca, Kadhim, Baleegh, Ghisotti, Daniela, Sassine, Jad, Straatman-Iwanowska, Anna, Bottrill, Andrew R., Moynihan, Patrick J., Wallis, Russell, Barthe, Philippe, Cohen-Gonsaud, Martin, Ajuh, Paul, Vollmer, Waldemar and Mukamolova, Galina (2018). Two Faces of CwIM, an Essential PknB Substrate, in Mycobacterium tuberculosis. Cell Reports, 25 (1), 57-67.E5. doi: 10.1016/j.celrep.2018.09.004
High-Resolution Analysis of the Peptidoglycan Composition in Streptomyces coelicolor

van der Aart, Lizah T., Spijksma, Gerwin K., Harms, Amy, Vollmer, Waldemar, Hankemeier, Thomas and van Wezel, Gilles P. (2018). High-Resolution Analysis of the Peptidoglycan Composition in Streptomyces coelicolor. Journal of Bacteriology, 200 (20). doi: 10.1128/JB.00290-18
The Fluorescent D-Amino Acid NADA as a Tool to Study the Conditional Activity of Transpeptidases in Escherichia coli

Montón Silva, Alejandro, Otten, Christian, Biboy, Jacob, Breukink, Eefjan, VanNieuwenhze, Michael, Vollmer, Waldemar and den Blaauwen, Tanneke (2018). The Fluorescent D-Amino Acid NADA as a Tool to Study the Conditional Activity of Transpeptidases in Escherichia coli. Frontiers in Microbiology, 9 2101, 1-15. doi: 10.3389/fmicb.2018.02101
The lytic transglycosylase MltB connects membrane homeostasis and in vivo fitness of Acinetobacter baumannii

Crepin, Sebastien, Ottosen, Elizabeth N., Peters, Katharina, Smith, Sara N., Himpsl, Stephanie D., Vollmer, Waldemar and Mobley, Harry L. T. (2018). The lytic transglycosylase MltB connects membrane homeostasis and in vivo fitness of Acinetobacter baumannii. Molecular Microbiology, 109 (6), 745-762. doi: 10.1111/mmi.14000
Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae

Morlot, Cecile, Straume, Daniel, Peters, Katharina, Hegnar, Olav A., Simon, Nolwenn, Villard, Anne-Marie, Contreras-Martel, Carlos, Leisico, Francisco, Breukink, Eefjan, Gravier-Pelletier, Christine, Le Corre, Laurent, Vollmer, Waldemar, Pietrancosta, Nicolas, Havarstein, Leiv Sigve and Zapun, Andre (2018). Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae. Nature Communications, 9 (1) 3180. doi: 10.1038/s41467-018-05602-w
Seven-transmembrane receptor protein RgsP and cell wall-binding protein RgsM promote unipolar growth in Rhizobiales

Schaeper, Simon, Yau, Hamish C. L., Krol, Elizaveta, Skotnicka, Dorota, Heimerl, Thomas, Gray, Joe, Kaever, Volkhard, Sogaard-Andersen, Lotte, Vollmer, Waldemar and Becker, Anke (2018). Seven-transmembrane receptor protein RgsP and cell wall-binding protein RgsM promote unipolar growth in Rhizobiales. Plos Genetics, 14 (8), e1007594. doi: 10.1371/journal.pgen.1007594
Mechanical interactions between bacteria and hydrogels

Kandemir, Nehir, Vollmer, Waldemar, Jakubovics, Nicholas S. and Chen, Jinju (2018). Mechanical interactions between bacteria and hydrogels. Scientific Reports, 8 (1) 10893. doi: 10.1038/s41598-018-29269-x
Coupling of polymerase and carrier lipid phosphatase prevents product inhibition in peptidoglycan synthesis

Hernández-Rocamora, Víctor M, Otten, Christian F., Radkov, Atanas, Simorre, Jean-Pierre, Breukink, Eefjan, VanNieuwenhze, Michael and Vollmer, Waldemar (2018). Coupling of polymerase and carrier lipid phosphatase prevents product inhibition in peptidoglycan synthesis. The Cell Surface, 2, 1-13. doi: 10.1016/j.tcsw.2018.04.002
Targeting the bacterial cytoskeleton of the Burkholderia cepacia complex for antimicrobial development: a cautionary tale

Carnell, Sonya C., Perry, John D., Borthwick, Lee, Vollmer, Daniela, Biboy, Jacob, Facchini, Marcella, Bragonzi, Alessandra, Silipo, Alba, Vergunst, Annette C., Vollmer, Waldemar, Khan, Anjam C. M. and De Soyza, Anthony (2018). Targeting the bacterial cytoskeleton of the Burkholderia cepacia complex for antimicrobial development: a cautionary tale. International Journal of Molecular Sciences, 19 (6), 1-13. doi: 10.3390/ijms19061604
The cell wall hydrolase Pmp23 is important for assembly and stability of the division ring in Streptococcus pneumoniae

Jacq, Maxime, Arthaud, Christopher, Manuse, Sylvie, Mercy, Chryslene, Bellard, Laure, Peters, Katharina, Gallet, Benoit, Galindo, Jennifer, Doan, Thierry, Vollmer, Waldemar, Brun, Yves V., VanNieuwenhze, Michael S., Di Guilmi, Anne Marie, Vernet, Thierry, Grangeasse, Christophe and Morlot, Cecile (2018). The cell wall hydrolase Pmp23 is important for assembly and stability of the division ring in Streptococcus pneumoniae. Scientific Reports, 8 (1) 7591. doi: 10.1038/s41598-018-25882-y
ArcR modulates biofilm formation in the dental plaque colonizer Streptococcus gordonii

Robinson, J. C., Rostami, N., Casement, J., Vollmer, W., Rickard, A. H. and Jakubovics, N. S. (2018). ArcR modulates biofilm formation in the dental plaque colonizer Streptococcus gordonii. Molecular Oral Microbiology, 33 (2), 143-154. doi: 10.1111/omi.12207
Bacterial cell wall precursor phosphatase assays using thin-layer chromatography (TLC) and high pressure liquid chromatography (HPLC)

Pazos, Manuel, Otten, Christian and Vollmer, Waldemar (2018). Bacterial cell wall precursor phosphatase assays using thin-layer chromatography (TLC) and high pressure liquid chromatography (HPLC). Bio-protocol, 8 (6), 1-14. doi: 10.21769/BioProtoc.2761
Stimulation of PgdA-dependent peptidoglycan N-deacetylation by GpsB-PBP A1 in Listeria monocytogenes

Rismondo, Jeanine, Wamp, Sabrina, Aldridge, Christine, Vollmer, Waldemar and Halbedel, Sven (2018). Stimulation of PgdA-dependent peptidoglycan N-deacetylation by GpsB-PBP A1 in Listeria monocytogenes. Molecular Microbiology, 107 (4), 472-487. doi: 10.1111/mmi.13893
Structure and activity of ChiX: a peptidoglycan hydrolase required for chitinase secretion by Serratia marcescens

Owen, Richard A., Fyfe, Paul K., Lodge, Adam, Biboy, Jacob, Vollmer, Waldemar, Hunter, William N. and Sargent, Frank (2018). Structure and activity of ChiX: a peptidoglycan hydrolase required for chitinase secretion by Serratia marcescens. Biochemical Journal, 475 (2), 415-428. doi: 10.1042/BCJ20170633
Peptidoglycan in obligate intracellular bacteria

Otten, Christian, Brilli, Matteo, Vollmer, Waldemar, Viollier, Patrick H. and Salje, Jeanne (2018). Peptidoglycan in obligate intracellular bacteria. Molecular Microbiology, 107 (2), 142-163. doi: 10.1111/mmi.13880
Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae

Hess, Nathalie, Waldow, Franziska, Kohler, Thomas P., Rohde, Manfred, Kreikemeyer, Bernd, Gomez-Mejia, Alejandro, Hain, Torsten, Schwudke, Dominik, Vollmer, Waldemar, Hammerschmidt, Sven and Gisch, Nicolas (2017). Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae. Nature Communications, 8 (1) 2093. doi: 10.1038/s41467-017-01720-z
Fluorescent D-amino-acids reveal bi-cellular cell wall modifications important for Bdellovibrio bacteriovorus predation

Kuru, Erkin, Lambert, Carey, Rittichier, Jonathan, Till, Rob, Ducret, Adrien, Derouaux, Adeline, Gray, Joe, Biboy, Jacob, Vollmer, Waldemar, VanNieuwenhze, Michael, Brun, Yves V. and Sockett, R. Elizabeth (2017). Fluorescent D-amino-acids reveal bi-cellular cell wall modifications important for Bdellovibrio bacteriovorus predation. Nature Microbiology, 2 (12), 1648-1657. doi: 10.1038/s41564-017-0029-y
Traceless Cleavage of Protein-Biotin Conjugates under Biologically Compatible Conditions

Cowell, Joseph, Buck, Matthew, Essa, Ali H., Clarke, Rebecca, Vollmer, Waldemar, Vollmer, Daniela, Hilkens, Catharien M., Isaacs, John D., Hall, Michael J. and Gray, Joe (2017). Traceless Cleavage of Protein-Biotin Conjugates under Biologically Compatible Conditions. ChemBioChem, 18 (17), 1688-1691. doi: 10.1002/cbic.201700214
AmiD Is a Novel Peptidoglycan Amidase in Wolbachia Endosymbionts of Drosophila melanogaster

Wilmes, Miriam, Meier, Kirstin, Schiefer, Andrea, Josten, Michaele, Otten, Christian F., Klockner, Anna, Henrichfreise, Beate, Vollmer, Waldemar, Hoerauf, Achim and Pfarr, Kenneth (2017). AmiD Is a Novel Peptidoglycan Amidase in Wolbachia Endosymbionts of Drosophila melanogaster. Frontiers in Cellular and Infection Microbiology, 7, 353. doi: 10.3389/fcimb.2017.00353
A broadly distributed toxin family mediates contact-dependent antagonism between gram-positive bacteria

Whitney, John C., Peterson, S. Brook, Kim, Jungyun, Pazos, Manuel, Verster, Adrian J., Radey, Matthew C., Kulasekara, Hemantha D., Ching, Mary Q., Bullen, Nathan P., Bryant, Diane, Goo, Young Ah, Surette, Michael G., Borenstein, Elhanan, Vollmer, Waldemar and Mougous, Joseph D. (2017). A broadly distributed toxin family mediates contact-dependent antagonism between gram-positive bacteria. eLife, 6, 1-24. doi: 10.7554/eLife.26938
New Aspects of the Interplay between Penicillin Binding Proteins, murM, and the Two-Component System CiaRH of Penicillin-Resistant Streptococcus pneumoniae Serotype 19A Isolates from Hungary

Schweizer, Inga, Blaettner, Sebastian, Maurer, Patrick, Peters, Katharina, Vollmer, Daniela, Vollmer, Waldemar, Hakenbeck, Regine and Denapaite, Dalia (2017). New Aspects of the Interplay between Penicillin Binding Proteins, murM, and the Two-Component System CiaRH of Penicillin-Resistant Streptococcus pneumoniae Serotype 19A Isolates from Hungary. Antimicrobial Agents and Chemotherapy, 61 (7). doi: 10.1128/AAC.00414-17
A mutant isoform of ObgE causes cell death by interfering with cell division

Dewachter, Liselot, Verstraeten, Natalie, Jennes, Michiel, Verbeelen, Tom, Biboy, Jacob, Monteyne, Daniel, Perez-Morga, David, Verstrepen, Kevin J., Vollmer, Waldemar, Fauvart, Maarten and Michiels, Jan (2017). A mutant isoform of ObgE causes cell death by interfering with cell division. Frontiers in Microbiology, 8, 1-12. doi: 10.3389/fmicb.2017.01193
Morphology heterogeneity within a Campylobacter jejuni helical population: the use of calcofluor white to generate rod-shaped C-jejuni 81-176 clones and the genetic determinants responsible for differences in morphology within 11168 strains

Frirdich, Emilisa, Biboy, Jacob, Huynh, Steven, Parker, Craig T., Vollmer, Waldemar and Gaynor, Erin C. (2017). Morphology heterogeneity within a Campylobacter jejuni helical population: the use of calcofluor white to generate rod-shaped C-jejuni 81-176 clones and the genetic determinants responsible for differences in morphology within 11168 strains. Molecular Microbiology, 104 (6), 948-971. doi: 10.1111/mmi.13672
Robust peptidoglycan growth by dynamic and variable multi-protein complexes

Pazos, Manuel, Peters, Katharina and Vollmer, Waldemar (2017). Robust peptidoglycan growth by dynamic and variable multi-protein complexes. Current Opinion in Microbiology, 36, 55-61. doi: 10.1016/j.mib.2017.01.006
Regulation of bacterial cell wall growth

Egan, Alexander J. F., Cleverley, Robert M., Peters, Katharina, Lewis, Richard J. and Vollmer, Waldemar (2017). Regulation of bacterial cell wall growth. The FEBS Journal, 284 (6), 851-867. doi: 10.1111/febs.13959
Interplay between Penicillin-binding proteins and SEDS proteins promotes bacterial cell wall synthesis

Leclercq, Sophie, Derouaux, Adeline, Olatunji, Samir, Fraipont, Claudine, Egan, Alexander J. F., Vollmer, Waldemar, Breukink, Eefjan and Terrak, Mohammed (2017). Interplay between Penicillin-binding proteins and SEDS proteins promotes bacterial cell wall synthesis. Scientific Reports, 7, 1-13. doi: 10.1038/srep43306
Site-Specific Immobilization of the Peptidoglycan Synthase PBP1B on a Surface Plasmon Resonance Chip Surface

van't Veer, Inge L., Leloup, Nadia O. L., Egan, Alexander J. F., Janssen, Bert J. C., Martin, Nathaniel I., Vollmer, Waldemar and Breukink, Eefjan (2016). Site-Specific Immobilization of the Peptidoglycan Synthase PBP1B on a Surface Plasmon Resonance Chip Surface. ChemBioChem, 17 (23), 2250-2256. doi: 10.1002/cbic.201600461
Accumulation of peptidoglycan O-acetylation leads to altered cell wall biochemistry and negatively impacts pathogenesis factors of Campylobacter jejuni

Ha, Reuben, Frirdich, Emilisa, Sychantha, David, Biboy, Jacob, Taveirne, Michael E., Johnson, Jeremiah G., DiRita, Victor J., Vollmer, Waldemar, Clarke, Anthony J. and Gaynor, Erin C. (2016). Accumulation of peptidoglycan O-acetylation leads to altered cell wall biochemistry and negatively impacts pathogenesis factors of Campylobacter jejuni. Journal of Biological Chemistry, 291 (43), 22686-22702. doi: 10.1074/jbc.M116.746404
A penicillin-binding protein inhibits selection of colistin-resistant, lipooligosaccharide-deficient Acinetobacter baumannii

Boll, Joseph M., Crofts, Alexander A., Peters, Katharina, Cattoir, Vincent, Vollmer, Waldemar, Davies, Bryan W. and Trent, M. Stephen (2016). A penicillin-binding protein inhibits selection of colistin-resistant, lipooligosaccharide-deficient Acinetobacter baumannii. Proceedings of the National Academy of Sciences of the United States of America, 113 (41), E6228-E6237. doi: 10.1073/pnas.1611594113
Subunit Arrangement in GpsB, a Regulator of Cell Wall Biosynthesis

Cleverley, Robert M., Rismondo, Jeanine, Lockhart-Cairns, Michael P., Van Bentum, Paulien T., Egan, Alexander J. F., Vollmer, Waldemar, Halbedel, Sven, Baldock, Clair, Breukink, Eefjan and Lewis, Richard J. (2016). Subunit Arrangement in GpsB, a Regulator of Cell Wall Biosynthesis. Microbial Drug Resistance, 22 (6), 446-460. doi: 10.1089/mdr.2016.0050
Lyme disease and relapsing fever Borrelia elongate through zones of peptidoglycan synthesis that mark division sites of daughter cells

Jutras, Brandon Lyon, Scott, Molly, Parry, Bradley, Biboy, Jacob, Gray, Joe, Vollmer, Waldemar and Jacobs-Wagner, Christine (2016). Lyme disease and relapsing fever Borrelia elongate through zones of peptidoglycan synthesis that mark division sites of daughter cells. Proceedings of the National Academy of Sciences, 113 (33), 9162-9170. doi: 10.1073/pnas.1610805113
Interrupting peptidoglycan deacetylation during Bdellovibrio predator-prey interaction prevents ultimate destruction of prey wall, liberating bacterial-ghosts

Lambert, Carey, Lerner, Thomas R., Bui, Nhat Khai, Somers, Hannah, Aizawa, Shin-Ichi, Liddell, Susan, Clark, Ana, Vollmer, Waldemar, Lovering, Andrew L. and Sockett, R. Elizabeth (2016). Interrupting peptidoglycan deacetylation during Bdellovibrio predator-prey interaction prevents ultimate destruction of prey wall, liberating bacterial-ghosts. Scientific Reports, 6, 1-19. doi: 10.1038/srep26010
The Redundancy of Peptidoglycan Carboxypeptidases Ensures Robust Cell Shape Maintenance in Escherichia coli

Peters, Katharina, Kannan, Suresh, Rao, Vincenzo A., Biboy, Jacob, Vollmer, Daniela, Erickson, Stephen W., Lewis, Richard J., Young, Kevin D. and Vollmer, Waldemar (2016). The Redundancy of Peptidoglycan Carboxypeptidases Ensures Robust Cell Shape Maintenance in Escherichia coli. mBio. doi: 10.1128/mBio.00819-16
Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus

Lambert, Carey, Cadby, Ian T., Till, Rob, Bui, Nhat Khai, Lerner, Thomas R., Hughes, William S., Lee, David J., Alderwick, Luke J., Vollmer, Waldemar, Sockett, R. Elizabeth and Lovering, Andrew L. (2015). Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus. Nature Communications, 6, 1-9. doi: 10.1038/ncomms9884
Substrate recognition and catalysis by LytB, a pneumococcal peptidoglycan hydrolase involved in virulence

Rico-Lastres, Palma, Diez-Martinez, Roberto, Iglesias-Bexiga, Manuel, Bustamante, Noemi, Aldridge, Christine, Hesek, Dusan, Lee, Mijoon, Mobashery, Shahriar, Gray, Joe, Vollmer, Waldemar, Garcia, Pedro and Menendez, Margarita (2015). Substrate recognition and catalysis by LytB, a pneumococcal peptidoglycan hydrolase involved in virulence. Scientific Reports, 5, 1-17. doi: 10.1038/srep16198
Activities and regulation of peptidoglycan synthases

Egan, Alexander J. F., Biboy, Jacob, van't Veer, Inge, Breukink, Eefjan and Vollmer, Waldemar (2015). Activities and regulation of peptidoglycan synthases. Philosophical Transactions of the Royal Society B-Biological Sciences, 370 (1679). doi: 10.1098/rstb.2015.0031
Transfer of penicillin resistance from Streptococcus oralis to Streptococcus pneumoniae identifies murE as resistance determinant

Todorova, Katya, Maurer, Patrick, Rieger, Martin, Becker, Tina, Bui, Nhat Khai, Gray, Joe, Vollmer, Waldemar and Hakenbeck, Regine (2015). Transfer of penicillin resistance from Streptococcus oralis to Streptococcus pneumoniae identifies murE as resistance determinant. Molecular Microbiology, 97 (5), 866-880. doi: 10.1111/mmi.13070
The external PASTA domain of the essential serine/threonine protein kinase PknB regulates mycobacterial growth

Turapov, Obolbek, Loraine, Jessica, Jenkins, Christopher H., Barthe, Philippe, McFeely, Daniel, Forti, Francesca, Ghisotti, Daniela, Hesek, Dusan, Lee, Mijoon, Bottrill, Andrew R., Vollmer, Waldemar, Mobashery, Shahriar, Cohen-Gonsaud, Martin and Mukamolova, Galina V. (2015). The external PASTA domain of the essential serine/threonine protein kinase PknB regulates mycobacterial growth. Open Biology, 5 (7), 1-13. doi: 10.1098/rsob.150025
Cell age dependent concentration of Escherichia coli divisome proteins analyzed with ImageJ and ObjectJ

Vischer, Norbert O. E., Verheul, Jolanda, Postma, Marten, van Saparoea, Bart van den Berg, Galli, Elise, Natale, Paolo, Gerdes, Kenn, Luirink, Joen, Vollmer, Waldemar, Vicente, Miguel and den Blaauwen, Tanneke (2015). Cell age dependent concentration of Escherichia coli divisome proteins analyzed with ImageJ and ObjectJ. Frontiers in Microbiology, 6. doi: 10.3389/fmicb.2015.00586
Two Putative Polysaccharide Deacetylases Are Required for Osmotic Stability and Cell Shape Maintenance in Bacillus anthracis

Arnaouteli, Sofia, Giastas, Petros, Andreou, Athina, Tzanodaskalaki, Mary, Aldridge, Christine, Tzartos, Socrates J., Vollmer, Waldemar, Eliopoulos, Elias and Bouriotis, Vassilis (2015). Two Putative Polysaccharide Deacetylases Are Required for Osmotic Stability and Cell Shape Maintenance in Bacillus anthracis. Journal of Biological Chemistry, 290 (21), 13465-13478. doi: 10.1074/jbc.M115.640029
The stoichiometric divisome: a hypothesis

Egan, Alexander J. F. and Vollmer, Waldemar (2015). The stoichiometric divisome: a hypothesis. Frontiers in Microbiology, 6, 1-6. doi: 10.3389/fmicb.2015.00455
Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division

Gray, Andrew N., Egan, Alexander J. F., van't Veer, Inge L., Verheul, Jolanda, Colavin, Alexandre, Koumoutsi, Alexandra, Biboy, Jacob, Altelaar, A. F. Maarten, Damen, Mirjam J., Huang, Kerwyn Casey, Simorre, Jean-Pierre, Breukink, Eefjan, den Blaauwen, Tanneke, Typas, Athanasios, Gross, Carol A. and Vollmer, Waldemar (2015). Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division. Elife, 4 e07118. doi: 10.7554/eLife.07118
Co-inactivation of GlnR and CodY regulators impacts pneumococcal cell wall physiology

Johnston, Calum, Bootsma, Hester J., Aldridge, Christine, Manuse, Sylvie, Gisch, Nicolas, Schwudke, Dominik, Hermans, Peter W. M., Grangeasse, Christophe, Polard, Patrice, Vollmer, Waldemar and Claverys, Jean-Pierre (2015). Co-inactivation of GlnR and CodY regulators impacts pneumococcal cell wall physiology. PLoS One, 10 (4), 1-22. doi: 10.1371/journal.pone.0123702
Backbone and side-chain 1H, 13C, and 15N NMR assignments of the N-terminal domain of Escherichia coli LpoA

Jean, Nicolas L., Bougault, Catherine, Derouaux, Adeline, Callens, Gilles, Vollmer, Waldemar and Simorre, Jean-Pierre (2015). Backbone and side-chain 1H, 13C, and 15N NMR assignments of the N-terminal domain of Escherichia coli LpoA. Biomolecular NMR Assignments, 9 (1), 65-69. doi: 10.1007/s12104-014-9546-2
Erratum: the host metabolite D-serine contributes to bacterial niche specificity through gene selection

Connolly, James P. R., Goldstone, Robert J., Burgess, Karl, Cogdell, Richard J., Beatson, Scott A., Vollmer, Waldemar, Smith, David G. E. and Roe, Andrew J. (2015). Erratum: the host metabolite D-serine contributes to bacterial niche specificity through gene selection. ISME Journal, 9 (4), 1052-1052. doi: 10.1038/ismej.2015.17
Solution NMR assignment of LpoB, an outer-membrane anchored Penicillin-Binding Protein activator from Escherichia coli

Jean, Nicolas L., Bougault, Catherine M., Egan, Alexander J. F., Vollmer, Waldemar and Simorre, Jean-Pierre (2015). Solution NMR assignment of LpoB, an outer-membrane anchored Penicillin-Binding Protein activator from Escherichia coli. Biomolecular Nmr Assignments, 9 (1), 123-127. doi: 10.1007/s12104-014-9557-z
Transferred interbacterial antagonism genes augment eukaryotic innate immune function

Chou, Seemay, Daugherty, Matthew D., Peterson, S. Brook, Biboy, Jacob, Yang, Youyun, Jutras, Brandon L., Fritz-Laylin, Lillian K., Ferrin, Michael A., Harding, Brittany N., Jacobs-Wagner, Christine, Yang, X. Frank, Vollmer, Waldemar, Malik, Harmit S. and Mougous, Joseph D. (2015). Transferred interbacterial antagonism genes augment eukaryotic innate immune function. Nature, 518 (7537), 98-101. doi: 10.1038/nature13965
Joachim-Volker Holtje (1941-2014) Obituary

Hakenbeck, Regine, de Pedro, Miguel, Romeis, Tina and Vollmer, Waldemar (2015). Joachim-Volker Holtje (1941-2014) Obituary. Molecular Microbiology, 95 (4), 573-575. doi: 10.1111/mmi.12881
Discrete and overlapping functions of peptidoglycan synthases in growth, cell division and virulence of Listeria monocytogenes

Rismondo, Jeanine, Moeller, Lars, Aldridge, Christine, Gray, Joe, Vollmer, Waldemar and Halbedel, Sven (2015). Discrete and overlapping functions of peptidoglycan synthases in growth, cell division and virulence of Listeria monocytogenes. Molecular Microbiology, 95 (2), 332-351. doi: 10.1111/mmi.12873
The host metabolite D-serine contributes to bacterial niche specificity through gene selection.

Connolly, James P., Goldstone, Robert J., Burgess, Karl, Cogdell, Richard J., Beatson, Scott A., Vollmer, Waldemar, Smith, David G. E. and Roe, Andrew J. (2014). The host metabolite D-serine contributes to bacterial niche specificity through gene selection.. The ISME Journal, 9 (4), 1039-1051. doi: 10.1038/ismej.2014.242
Structure and function of a spectrin-like regulator of bacterial cytokinesis

Cleverley, Robert M., Barrett, Jeffrey R., Baslé, Arnaud, Bui, Nhat Khai, Hewitt, Lorraine, Solovyova, Alexandra, Xu, Zhi-Qiang, Daniel, Richard A., Dixon, Nicholas E., Harry, Elizabeth J., Oakley, Aaron J., Vollmer, Waldemar and Lewis, Richard J. (2014). Structure and function of a spectrin-like regulator of bacterial cytokinesis. Nature Communications, 5 (1) 5421. doi: 10.1038/ncomms6421
TLR-Mediated Inflammatory Responses to Streptococcus pneumoniae Are Highly Dependent on Surface Expression of Bacterial Lipoproteins

Tomlinson, Gillian, Chimalapati, Suneeta, Pollard, Tracey, Lapp, Thabo, Cohen, Jonathan, Camberlein, Emilie, Stafford, Sian, Periselneris, Jimstan, Aldridge, Christine, Vollmer, Waldemar, Picard, Capucine, Casanova, Jean-Laurent, Noursadeghi, Mahdad and Brown, Jeremy (2014). TLR-Mediated Inflammatory Responses to Streptococcus pneumoniae Are Highly Dependent on Surface Expression of Bacterial Lipoproteins. Journal of Immunology, 193 (7), 3736-3745. doi: 10.4049/jimmunol.1401413
Elongated structure of the outer-membrane activator of peptidoglycan synthesis LpoA: implications for PBP1A stimulation

Jean, Nicolas L., Bougault, Catherine M., Lodge, Adam, Derouaux, Adeline, Callens, Gilles, Egan, Alexander J.F., Ayala, Isabel, Lewis, Richard J., Vollmer, Waldemar and Simorre, Jean-Pierre (2014). Elongated structure of the outer-membrane activator of peptidoglycan synthesis LpoA: implications for PBP1A stimulation. Structure, 22 (7), 1047-1054. doi: 10.1016/j.str.2014.04.017
Structure of the LdcB LD-carboxypeptidase reveals the molecular basis of peptidoglycan recognition

Hoyland, Christopher N., Aldridge, Christine, Cleverley, Robert M., Duchêne, Marie-Clémence, Minasov, George, Onopriyenko, Olena, Sidiq, Karzan, Stogios, Peter J., Anderson, Wayne F., Daniel, Richard A., Savchenko, Alexei, Vollmer, Waldemar and Lewis, Richard J. (2014). Structure of the LdcB LD-carboxypeptidase reveals the molecular basis of peptidoglycan recognition. Structure, 22 (7), 949-960. doi: 10.1016/j.str.2014.04.015
Outer-membrane lipoprotein LpoB spans the periplasm to stimulate the peptidoglycan synthase PBP1B

Egan, Alexander J. F., Jean, Nicolas L., Koumoutsi, Alexandra, Bougault, Catherine M., Biboy, Jacob, Sassine, Jad, Solovyova, Alexandra S., Breukink, Eefjan, Typas, Athanasios, Vollmer, Waldemar and Simorre, Jean-Pierre (2014). Outer-membrane lipoprotein LpoB spans the periplasm to stimulate the peptidoglycan synthase PBP1B. Proceedings of the National Academy of Sciences of the United States of America, 111 (22), 8197-8202. doi: 10.1073/pnas.1400376111
AmiA is a penicillin target enzyme with dual activity in the intracellular pathogen Chlamydia pneumoniae

Kloeckner, Anna, Otten, Christian, Derouaux, Adeline, Vollmer, Waldemar, Buehl, Henrike, De Benedetti, Stefania, Muench, Daniela, Josten, Michaele, Moelleken, Katja, Sahl, Hans-Georg and Henrichfreise, Beate (2014). AmiA is a penicillin target enzyme with dual activity in the intracellular pathogen Chlamydia pneumoniae. Nature Communications, 5, 1-10. doi: 10.1038/ncomms5201
Peptidoglycan ld-carboxypeptidase Pgp2 influences Campylobacter jejuni helical cell shape and pathogenic properties and provides the substrate for the DL-carboxypeptidase Pgp1

Frirdich, Emilisa, Vermeulen, Jenny, Biboy, Jacob, Soares, Fraser, Taveirne, Michael E., Johnson, Jeremiah G., DiRita, Victor J., Girardin, Stephen E., Vollmer, Waldemar and Gaynor, Erin C. (2014). Peptidoglycan ld-carboxypeptidase Pgp2 influences Campylobacter jejuni helical cell shape and pathogenic properties and provides the substrate for the DL-carboxypeptidase Pgp1. Journal of Biological Chemistry, 289 (12), 8007-8018. doi: 10.1074/jbc.M113.491829
Different walls for rods and balls: the diversity of peptidoglycan

Turner, Robert D., Vollmer, Waldemar and Foster, Simon J. (2014). Different walls for rods and balls: the diversity of peptidoglycan. Molecular Microbiology, 91 (5), 862-874. doi: 10.1111/mmi.12513
Discovery of chlamydial peptidoglycan reveals bacteria with murein sacculi but without FtsZ

Pilhofer, Martin, Aistleitner, Karin, Biboy, Jacob, Gray, Joe, Kuru, Erkin, Hall, Edward, Brun, Yves V., VanNieuwenhze, Michael S., Vollmer, Waldemar, Horn, Matthias and Jensen, Grant J. (2013). Discovery of chlamydial peptidoglycan reveals bacteria with murein sacculi but without FtsZ. Nature Communications, 4, 1-7. doi: 10.1038/ncomms3856
From models to pathogens: how much have we learned about Streptococcus pneumoniae cell division?

Massidda, Orietta, Novakova, Linda and Vollmer, Waldemar (2013). From models to pathogens: how much have we learned about Streptococcus pneumoniae cell division?. Environmental Microbiology, 15 (12), 3133-3157. doi: 10.1111/1462-2920.12189
Mechanisms of bacterial morphogenesis and their subversion by phages

Bernhardt, Thomas G. and Vollmer, Waldemar (2013). Mechanisms of bacterial morphogenesis and their subversion by phages. Current Opinion in Microbiology, 16 (6), 728-730. doi: 10.1016/j.mib.2013.10.004
Structural basis for type VI secreted peptidoglycan DL-endopeptidase function, specificity and neutralization in Serratia marcescens

Srikannathasan, Velupillai, English, Grant, Bui, Nhat Khai, Trunk, Katharina, O'Rourke, Patrick E. F., Rao, Vincenzo A., Vollmer, Waldemar, Coulthurst, Sarah J. and Hunter, William N. (2013). Structural basis for type VI secreted peptidoglycan DL-endopeptidase function, specificity and neutralization in Serratia marcescens. Acta Crystallographica. Section D: Structural Biology, 69 (Pt 12), 2468-2482. doi: 10.1107/S0907444913022725
Flow cytometry-based enrichment for cell shape mutants identifies multiple genes that influence Helicobacter pylori morphology

Sycuro, Laura K., Rule, Chelsea S., Petersen, Timothy W., Wyckoff, Timna J., Sessler, Tate, Nagarkar, Dilip B., Khalid, Fakhra, Pincus, Zachary, Biboy, Jacoby, Vollmer, Waldemar and Salama, Nina R. (2013). Flow cytometry-based enrichment for cell shape mutants identifies multiple genes that influence Helicobacter pylori morphology. Molecular Microbiology, 90 (4), 869-883. doi: 10.1111/mmi.12405
Identification, Structure, and Function of a Novel Type VI Secretion Peptidoglycan Glycoside Hydrolase Effector-Immunity Pair

Whitney, John C., Chou, Seemay, Russell, Alistair B., Biboy, Jacob, Gardiner, Taylor E., Ferrin, Michael A., Brittnacher, Mitchell, Vollmer, Waldemar and Mougous, Joseph D. (2013). Identification, Structure, and Function of a Novel Type VI Secretion Peptidoglycan Glycoside Hydrolase Effector-Immunity Pair. Journal of Biological Chemistry, 288 (37), 26616-26624. doi: 10.1074/jbc.M113.488320
Colocalization and interaction between elongasome and divisome during a preparative cell division phase in Escherichia coli

van der Ploeg, Rene, Verheul, Jolanda, Vischer, Norbert O. E., Alexeeva, Svetlana, Hoogendoorn, Eelco, Postma, Marten, Banzhaf, Manuel, Vollmer, Waldemar and den Blaauwen, Tanneke (2013). Colocalization and interaction between elongasome and divisome during a preparative cell division phase in Escherichia coli. Molecular Microbiology, 87 (5), 1074-1087. doi: 10.1111/mmi.12150
Growth medium-dependent glycine incorporation into the peptidoglycan of Caulobacter crescentus

Takacs, Constantin N., Hocking, Jason, Cabeen, Matthew T., Bui, Nhat Khai, Poggio, Sebastian, Vollmer, Waldemar and Jacobs-Wagner, Christine (2013). Growth medium-dependent glycine incorporation into the peptidoglycan of Caulobacter crescentus. Plos One, 8 (2) e57579. doi: 10.1371/journal.pone.0057579
Glutamate 83 and arginine 85 of helix H3 bend are key residues for FtsZ polymerization, GTPase activity and cellular viability of Escherichia coli: lateral mutations affect FtsZ polymerization and E. coli viability

Shin, Jae Yen, Vollmer, Waldemar, Lagos, Rosalba and Monasterio, Octavio (2013). Glutamate 83 and arginine 85 of helix H3 bend are key residues for FtsZ polymerization, GTPase activity and cellular viability of Escherichia coli: lateral mutations affect FtsZ polymerization and E. coli viability. BMC Microbiology, 13 26. doi: 10.1186/1471-2180-13-26
In vitro peptidoglycan synthesis assay with lipid II substrate

Biboy, Jacob, Bui, Nhat Khai and Vollmer, Waldemar (2013). In vitro peptidoglycan synthesis assay with lipid II substrate. Methods in Molecular Biology, 966, 273-288. doi: 10.1007/978-1-62703-245-2_17
The physiology of bacterial cell division

Egan, Alexander J. F. and Vollmer, Waldemar (2013). The physiology of bacterial cell division. Annals of the New York Academy of Sciences, 1277 (1), 8-28. doi: 10.1111/j.1749-6632.2012.06818.x
Bacterial growth does require peptidoglycan hydrolases

Vollmer, Waldemar (2012). Bacterial growth does require peptidoglycan hydrolases. Molecular Microbiology, 86 (5), 1031-1035. doi: 10.1111/mmi.12059
Cooperativity of peptidoglycan synthases active in bacterial cell elongation

Banzhaf, Manuel, van Saparoea, Bart van den Berg, Terrak, Mohammed, Fraipont, Claudine, Egan, Alexander, Philippe, Jules, Zapun, Andre, Breukink, Eefjan, Martine Nguyen-Disteche, , den Blaauwen, Tanneke and Vollmer, Waldemar (2012). Cooperativity of peptidoglycan synthases active in bacterial cell elongation. Molecular Microbiology, 85 (1), 179-194. doi: 10.1111/j.1365-2958.2012.08103.x
Attachment of capsular polysaccharide to the cell wall in Streptococcus pneumoniae

Eberhardt, Alice, Hoyland, Christopher N., Vollmer, Daniela, Bisle, Stephanie, Cleverley, Robert M., Johnsborg, Ola, Håvarstein, Leiv S., Lewis, Richard J. and Vollmer, Waldemar (2012). Attachment of capsular polysaccharide to the cell wall in Streptococcus pneumoniae. Microbial Drug Resistance, 18 (3), 240-255. doi: 10.1089/mdr.2011.0232
Biosynthesis of Teichoic Acids in Streptococcus pneumoniae and Closely Related Species: Lessons from Genomes

Denapaite, Dalia, Brueckner, Reinhold, Hakenbeck, Regine and Vollmer, Waldemar (2012). Biosynthesis of Teichoic Acids in Streptococcus pneumoniae and Closely Related Species: Lessons from Genomes. Microbial Drug Resistance, 18 (3), 344-358. doi: 10.1089/mdr.2012.0026
Osmolality-dependent relocation of penicillin-binding protein PBP2 to the division site in Caulobacter crescentus

Hocking, Jason, Priyadarshini, Richa, Takacs, Constantin N., Costa, Teresa, Dye, Natalie A., Shapiro, Lucy, Vollmer, Waldemar and Jacobs-Wagner, Christine (2012). Osmolality-dependent relocation of penicillin-binding protein PBP2 to the division site in Caulobacter crescentus. Journal of Bacteriology, 194 (12), 3116-3127. doi: 10.1128/JB.00260-12
Structure of a Peptidoglycan Amidase Effector Targeted to Gram-Negative Bacteria by the Type VI Secretion System

Chou, Seemay, Bui, Nhat Khai, Russell, Alistair B., Lexa, Katrina W., Gardiner, Taylor E., LeRoux, Michele, Vollmer, Waldemar and Mougous, Joseph D. (2012). Structure of a Peptidoglycan Amidase Effector Targeted to Gram-Negative Bacteria by the Type VI Secretion System. Cell Reports, 1 (6), 656-664. doi: 10.1016/j.celrep.2012.05.016
The membrane anchor of penicillin-binding protein PBP2a from Streptococcus pneumoniae influences peptidoglycan chain length

Helassa, Nordine, Vollmer, Waldemar, Breukink, Eefjan, Vernet, Thierry and Zapun, Andre (2012). The membrane anchor of penicillin-binding protein PBP2a from Streptococcus pneumoniae influences peptidoglycan chain length. Febs Journal, 279 (11), 2071-2081. doi: 10.1111/j.1742-4658.2012.08592.x
A widespread bacterial type VI secretion effector superfamily identified using a heuristic approach

Russell, Alistair B., Singh, Pragya, Brittnacher, Mitchell, Bui, Nhat Khai, Hood, Rachel D., Carl, Mike A., Agnello, Danielle M., Schwarz, Sandra, Goodlett, David R., Vollmer, Waldemar and Mougous, Joseph D. (2012). A widespread bacterial type VI secretion effector superfamily identified using a heuristic approach. Cell Host and Microbe, 11 (5), 538-549. doi: 10.1016/j.chom.2012.04.007
Characterization of DalS, an ATP-binding Cassette Transporter for D-Alanine, and Its Role in Pathogenesis in Salmonella enterica

Osborne, Suzanne E., Tuinema, Brian R., Mok, Mac C. Y., Lau, Pui Sai, Bui, Nhat Khai, Tomljenovic-Berube, Ana M., Vollmer, Waldemar, Zhang, Kun, Junop, Murray and Coombes, Brian K. (2012). Characterization of DalS, an ATP-binding Cassette Transporter for D-Alanine, and Its Role in Pathogenesis in Salmonella enterica. Journal of Biological Chemistry, 287 (19), 15242-15250. doi: 10.1074/jbc.M112.348227
Multiple peptidoglycan modification networks modulate Helicobacter pylori's cell shape, motility, and colonization potential

Sycuro, Laura K., Wyckoff, Timna J., Biboy, Jacob, Born, Petra, Pincus, Zachary, Vollmer, Waldemar and Salama, Nina R. (2012). Multiple peptidoglycan modification networks modulate Helicobacter pylori's cell shape, motility, and colonization potential. PLoS Pathogens, 8 (3), 1-14. doi: 10.1371/journal.ppat.1002603
Peptidoglycan-modifying enzyme pgp1 is required for helical cell shape and pathogenicity traits in Campylobacter jejuni

Frirdich, Emilisa, Biboy, Jacob, Adams, Calvin, Lee, Jooeun, Ellermeier, Jeremy, Gielda, Lindsay Davis, DiRita, Victor J., Girardin, Stephen E., Vollmer, Waldemar and Gaynor, Erin C. (2012). Peptidoglycan-modifying enzyme pgp1 is required for helical cell shape and pathogenicity traits in Campylobacter jejuni. PLoS Pathogens, 8 (3), 1-14. doi: 10.1371/journal.ppat.1002602
Isolation and analysis of cell wall components from Streptococcus pneumoniae

Bui, Nhat Khai, Eberhardt, Alice, Vollmer, Daniela, Kern, Thomas, Bougault, Catherine, Tomasz, Alexander, Simorre, Jean-Pierre and Vollmer, Waldemar (2012). Isolation and analysis of cell wall components from Streptococcus pneumoniae. Analytical Biochemistry, 421 (2), 657-666. doi: 10.1016/j.ab.2011.11.026
From the regulation of peptidoglycan synthesis to bacterial growth and morphology

Typas, Athanasios, Banzhaf, Manuel, Gross, Carol A. and Vollmer, Waldemar (2012). From the regulation of peptidoglycan synthesis to bacterial growth and morphology. Nature Reviews Microbiology, 10 (2), 123-136. doi: 10.1038/nrmicro2677
Specialized Peptidoglycan Hydrolases Sculpt the Intra-bacterial Niche of Predatory Bdellovibrio and Increase Population Fitness

Lerner, Thomas R., Lovering, Andrew L., Nhat Khai Bui, , Uchida, Kaoru, Aizawa, Shin-Ichi, Vollmer, Waldemar and Sockett, R. Elizabeth (2012). Specialized Peptidoglycan Hydrolases Sculpt the Intra-bacterial Niche of Predatory Bdellovibrio and Increase Population Fitness. PLoS Pathogens, 8 (2). doi: 10.1371/journal.ppat.1002524
Bacterial outer membrane evolution via sporulation?

Vollmer, Waldemar (2012). Bacterial outer membrane evolution via sporulation?. Nature Chemical Biology, 8 (1), 14-18. doi: 10.1038/nchembio.748
Identification of genetic determinants and enzymes involved with the amidation of glutamic acid residues in the peptidoglycan of Staphylococcus aureus

Figueiredo, Teresa A., Sobral, Rita G., Ludovice, Ana Madalena, Feio de Almeida, Joao Manuel, Bui, Nhat K., Vollmer, Waldemar, de Lencastre, Herminia and Tomasz, Alexander (2012). Identification of genetic determinants and enzymes involved with the amidation of glutamic acid residues in the peptidoglycan of Staphylococcus aureus. PLoS Pathogens, 8 (1), 1-13. doi: 10.1371/journal.ppat.1002508
A widespread family of bacterial cell wall assembly proteins

Kawai, Yoshikazu, Marles-Wright, Jon, Cleverley, Robert M., Emmins, Robyn, Ishikawa, Shu, Kuwano, Masayoshi, Heinz, Nadja, Bui, Nhat Khai, Hoyland, Christopher N., Ogasawara, Naotake, Lewis, Richard J., Vollmer, Waldemar, Daniel, Richard A. and Errington, Jeff (2011). A widespread family of bacterial cell wall assembly proteins. EMBO Journal, 30 (24), 4931-4941. doi: 10.1038/emboj.2011.358
Self-Resistance and Cell Wall Composition in the Glycopeptide Producer Amycolatopsis balhimycina

Schaeberle, Till F., Vollmer, Waldemar, Frasch, Hans-Joerg, Huettel, Stephan, Kulik, Andreas, Roettgen, Marlene, von Thaler, Anna-Katharina, Wohlleben, Wolfgang and Stegmann, Evi (2011). Self-Resistance and Cell Wall Composition in the Glycopeptide Producer Amycolatopsis balhimycina. Antimicrobial Agents and Chemotherapy, 55 (9), 4283-4289. doi: 10.1128/AAC.01372-10
Type VI secretion delivers bacteriolytic effectors to target cells

Russell, Alistair B., Hood, Rachel D., Bui, Nhat Khai, LeRoux, Michele, Vollmer, Waldemar and Mougous, Joseph D. (2011). Type VI secretion delivers bacteriolytic effectors to target cells. Nature, 475 (7356), 343-347. doi: 10.1038/nature10244
Acquisition of VanB-type vancomycin resistance by Bacillus subtilis: the impact on gene expression, cell wall composition and morphology

Bisicchia, Paola, Nhat Khai Bui, , Aldridge, Christine, Vollmer, Waldemar and Devine, Kevin M. (2011). Acquisition of VanB-type vancomycin resistance by Bacillus subtilis: the impact on gene expression, cell wall composition and morphology. Molecular Microbiology, 81 (1), 157-178. doi: 10.1111/j.1365-2958.2011.07684.x
Development of screening assays and discovery of initial inhibitors of pneumococcal peptidoglycan deacetylase PgdA

Bui, Nhat Khai, Turk, Samo, Buckenmaier, Stephan, Stevenson-Jones, Flint, Zeuch, Benjamin, Gobec, Stanislav and Vollmer, Waldemar (2011). Development of screening assays and discovery of initial inhibitors of pneumococcal peptidoglycan deacetylase PgdA. Biochemical Pharmacology, 82 (1), 43-52. doi: 10.1016/j.bcp.2011.03.028
A Novel in vivo Cell-Wall Labeling Approach Sheds New Light on Peptidoglycan Synthesis in Escherichia coli

Olrichs, Nick K., Aarsman, Mirjam E. G., Verheul, Jolanda, Arnusch, Christopher J., Martin, Nathaniel I., Herve, Mireille, Vollmer, Waldemar, de Kruijff, Ben, Breukink, Eefjan and den Blaauwen, Tanneke (2011). A Novel in vivo Cell-Wall Labeling Approach Sheds New Light on Peptidoglycan Synthesis in Escherichia coli. ChemBioChem, 12 (7), 1124-1133. doi: 10.1002/cbic.201000552
Regulation of Peptidoglycan Synthesis by Outer-Membrane Proteins

Typas, Athanasios, Banzhaf, Manuel, van Saparoea, Bart van den Berg, Verheul, Jolanda, Biboy, Jacob, Nichols, Robert J., Zietek, Matylda, Beilharz, Katrin, Kannenberg, Kai, von Rechenberg, Moritz, Breukink, Eefjan, den Blaauwen, Tanneke, Gross, Carol A. and Vollmer, Waldemar (2010). Regulation of Peptidoglycan Synthesis by Outer-Membrane Proteins. Cell, 143 (7), 1097-1109. doi: 10.1016/j.cell.2010.11.038
Dynamics Characterization of Fully Hydrated Bacterial Cell Walls by Solid-State NMR: Evidence for Cooperative Binding of Metal Ions

Kern, Thomas, Giffard, Mathilde, Hediger, Sabine, Amoroso, Ana, Giustini, Cecile, Bui, Nhat Khai, Joris, Bernard, Bougault, Catherine, Vollmer, Waldemar and Simorre, Jean-Pierre (2010). Dynamics Characterization of Fully Hydrated Bacterial Cell Walls by Solid-State NMR: Evidence for Cooperative Binding of Metal Ions. Journal of the American Chemical Society, 132 (31), 10911-10919. doi: 10.1021/ja104533w
A protein critical for cell constriction in the Gram-negative bacterium Caulobacter crescentus localizes at the division site through its peptidoglycan-binding LysM domains

Poggio, Sebastian, Takacs, Constantin N., Vollmer, Waldemar and Jacobs-Wagner, Christine (2010). A protein critical for cell constriction in the Gram-negative bacterium Caulobacter crescentus localizes at the division site through its peptidoglycan-binding LysM domains. Molecular Microbiology, 77 (1), 74-89. doi: 10.1111/j.1365-2958.2010.07223.x
Mutations in the lipopolysaccharide biosynthesis pathway interfere with crescentin-mediated cell curvature in Caulobacter crescentus

Cabeen, Matthew T., Murolo, Michelle A., Briegel, Ariane, Bui, N. Khai, Vollmer, Waldemar, Ausmees, Nora, Jensen, Grant J. and Jacobs-Wagner, Christine (2010). Mutations in the lipopolysaccharide biosynthesis pathway interfere with crescentin-mediated cell curvature in Caulobacter crescentus. Journal of Bacteriology, 192 (13), 3368-3378. doi: 10.1128/JB.01371-09
Septal and lateral wall localization of PBP5, the major D,D-carboxypeptidase of Escherichia coli, requires substrate recognition and membrane attachment

Potluri, Lakshmiprasad, Karczmarek, Aneta, Verheul, Jolanda, Piette, Andre, Wilkin, Jean-Marc, Werth, Nadine, Banzhaf, Manuel, Vollmer, Waldemar, Young, Kevin D., Nguyen-Disteche, Martine and den Blaauwen, Tanneke (2010). Septal and lateral wall localization of PBP5, the major D,D-carboxypeptidase of Escherichia coli, requires substrate recognition and membrane attachment. Molecular Microbiology, 77 (2), 300-323. doi: 10.1111/j.1365-2958.2010.07205.x
Peptidoglycan crosslinking relaxation promotes Helicobacter pylori's helical shape and stomach colonization

Sycuro, Laura K., Pincus, Zachary, Gutierrez, Kimberley D., Biboy, Jacob, Stern, Chelsea A., Vollmer, Waldemar and Salama, Nina R. (2010). Peptidoglycan crosslinking relaxation promotes Helicobacter pylori's helical shape and stomach colonization. Cell, 141 (5), 822-833. doi: 10.1016/j.cell.2010.03.046
Insights into pneumococcal fratricide from the crystal structures of the modular killing factor LytC

Perez-Dorado, Inmaculada, Gonzalez, Ana, Morales, Maria, Sanles, Reyes, Striker, Waldemar, Vollmer, Waldemar, Mobashery, Shahriar, Garcia, Jose L., Martinez-Ripoll, Martin, Garcia, Pedro and Hermoso, Juan A. (2010). Insights into pneumococcal fratricide from the crystal structures of the modular killing factor LytC. Nature Structural and Molecular Biology, 17 (5), 576-581. doi: 10.1038/nsmb.1817
MreB drives de novo rod morphogenesis in Caulobacter crescentus via remodeling of the cell wall

Takacs, Constantin N., Poggio, Sebastian, Charbon, Godefroid, Pucheault, Mathieu, Vollmer, Waldemar and Jacobs-Wagner, Christine (2010). MreB drives de novo rod morphogenesis in Caulobacter crescentus via remodeling of the cell wall. Journal of Bacteriology, 192 (6), 1671-1684. doi: 10.1128/JB.01311-09
Architecture of peptidoglycan: more data and more models

Vollmer, Waldemar and Seligman, Stephen J. (2010). Architecture of peptidoglycan: more data and more models. Trends in Microbiology, 18 (2), 59-66. doi: 10.1016/j.tim.2009.12.004
Cellular localization of choline-utilization proteins in Streptococcus pneumoniae using novel fluorescent reporter systems

Eberhardt, Alice, Wu, Ling J., Errington, Jeff, Vollmer, Waldemar and Veening, Jan-Willem (2009). Cellular localization of choline-utilization proteins in Streptococcus pneumoniae using novel fluorescent reporter systems. Molecular Microbiology, 74 (2), 395-408. doi: 10.1111/j.1365-2958.2009.06872.x
Role of Teichoic Acid Choline Moieties in the Virulence of Streptococcus pneumoniae

Gehre, Florian, Spisek, Radek, Kharat, Arun S., Matthews, Phillip, Kukreja, Anjli, Anthony, Robert M., Dhodapkar, Madhav V., Vollmer, Waldemar and Tomasz, Alexander (2009). Role of Teichoic Acid Choline Moieties in the Virulence of Streptococcus pneumoniae. Infection and Immunity, 77 (7), 2824-2831. doi: 10.1128/IAI.00986-08
Bacterial cell curvature through mechanical control of cell growth

Cabeen, Matthew T., Charbon, Godefroid, Vollmer, Waldemar, Born, Petra, Ausmees, Nora, Weibel, Douglas B. and Jacobs-Wagner, Christine (2009). Bacterial cell curvature through mechanical control of cell growth. Embo Journal, 28 (9), 1208-1219. doi: 10.1038/emboj.2009.61
Murein: The dynamic exoskeleton of bacteria Das dynamische exoskelett der bakterien

Vollmer, Waldemar (2009). Murein: The dynamic exoskeleton of bacteria Das dynamische exoskelett der bakterien. BioSpektrum, 15 (3), 248-251.
Polyphosphates from Mycobacterium bovis- potent inhibitors of class III adenylate cyclases

Guo, Ying Lan, Mayer, Hermann, Vollmer, Waldemar, Dittrich, Dorothea, Sander, Peter, Schultz, Anita and Schultz, Joachim E. (2009). Polyphosphates from Mycobacterium bovis- potent inhibitors of class III adenylate cyclases. FEBS Journal, 276 (4), 1094-1103. doi: 10.1111/j.1742-4658.2008.06852.x
Synthesis of CDP-activated ribitol for teichoic acid precursors in Streptococcus pneumoniae

Baur, Stefanie, Maries-Wright, Jon, Buckenmaier, Stephan, Lewis, Richard J. and Vollmer, Waldemar (2009). Synthesis of CDP-activated ribitol for teichoic acid precursors in Streptococcus pneumoniae. Journal of Bacteriology, 191 (4), 1200-1210. doi: 10.1128/JB.01120-08
The Peptidoglycan Sacculus of Myxococcus xanthus Has Unusual Structural Features and Is Degraded during Glycerol-Induced Myxospore Development

Bui, Nhat Khai, Gray, Joe, Schwarz, Heinz, Schumann, Peter, Blanot, Didier and Vollmer, Waldemar (2009). The Peptidoglycan Sacculus of Myxococcus xanthus Has Unusual Structural Features and Is Degraded during Glycerol-Induced Myxospore Development. Journal of Bacteriology, 191 (2), 494-505. doi: 10.1128/JB.00608-08
Significant contribution of the pgdA gene to the virulence of Streptococcus suis

Fittipaldi, Nahuel, Sekizaki, Tsutomu, Takamatsu, Daisuke, Dominguez-Punaro, Maria de la Cruz, Harel, Josee, Bui, Nhat Khai, Vollmer, Waldemar and Gottschalk, Marcelo (2008). Significant contribution of the pgdA gene to the virulence of Streptococcus suis. Molecular Microbiology, 70 (5), 1120-1135. doi: 10.1111/j.1365-2958.2008.06463.x
Different pathways of choline metabolism in two choline-independent strains of Streptococcus pneumoniae and their impact on virulence

Kharat, Arun S., Denapaite, Dalia, Gehre, Florian, Brueckner, Reinhold, Vollmer, Waldemar, Hakenbeck, Regine and Tomasz, Alexander (2008). Different pathways of choline metabolism in two choline-independent strains of Streptococcus pneumoniae and their impact on virulence. Journal of Bacteriology, 190 (17), 5907-5914. doi: 10.1128/JB.00628-08
Murein (peptidoglycan) structure, architecture and biosynthesis in Escherichia coli

Vollmer, Waldemar and Bertsche, Ute (2008). Murein (peptidoglycan) structure, architecture and biosynthesis in Escherichia coli. Biochimica Et Biophysica Acta-Biomembranes, 1778 (9), 1714-1734. doi: 10.1016/j.bbamem.2007.06.007
Toward the characterization of peptidoglycan structure and protein - Peptidoglycan interactions by solid-state NMR Spectroscopy

Kern, Thomas, Hediger, Sabine, Mueller, Patrick, Giustini, Cecile, Joris, Bernard, Bougault, Catherine, Vollmer, Waldemar and Simorre, Jean-Pierre (2008). Toward the characterization of peptidoglycan structure and protein - Peptidoglycan interactions by solid-state NMR Spectroscopy. Journal of the American Chemical Society, 130 (17), 5618-5619. doi: 10.1021/ja7108135
Bacterial peptidoglycan (murein) hydrolases

Vollmer, Waldemar, Joris, Bernard, Charlier, Paulette and Foster, Simon (2008). Bacterial peptidoglycan (murein) hydrolases. FEMS Microbiology Reviews, 32 (2), 259-286. doi: 10.1111/j.1574-6976.2007.00099.x
Peptidoglycan structure and architecture

Vollmer, Waldemar, Blanot, Didier and de Pedro, Miguel A. (2008). Peptidoglycan structure and architecture. FEMS Microbiology Reviews, 32 (2), 149-167. doi: 10.1111/j.1574-6976.2007.00094.x
Structural variation in the glycan strands of bacterial peptidoglycan

Vollmer, Waldemar (2008). Structural variation in the glycan strands of bacterial peptidoglycan. FEMS Microbiology Reviews, 32 (2), 287-306. doi: 10.1111/j.1574-6976.2007.00088.x
Targeting the bacterial Z-ring

Vollmer, Waldemar (2008). Targeting the bacterial Z-ring. Chemistry and Biology, 15 (2), 93-94. doi: 10.1016/j.chembiol.2008.02.001
The essential cell division protein FtsN interacts with the murein (peptidoglycan) synthase PBP1B in Escherichia coli

Mueller, Patrick, Ewers, Carolin, Bertsche, Ute, Anstett, Maria, Kallis, Tanja, Breukink, Eefjan, Fraipont, Claudine, Terrak, Mohammed, Nguyen-Disteche, Martine and Vollmer, Waldemar (2007). The essential cell division protein FtsN interacts with the murein (peptidoglycan) synthase PBP1B in Escherichia coli. Journal of Biological Chemistry, 282 (50), 36394-36402. doi: 10.1074/jbc.M706390200
The essential tacF gene is responsible for the choline-dependent growth phenotype of Streptococcus pneumoniae

Damjanovic, Marlen, Kharat, Arun S., Eberhardt, Alice, Tomasz, Alexander and Vollmer, Waldemar (2007). The essential tacF gene is responsible for the choline-dependent growth phenotype of Streptococcus pneumoniae. Journal of Bacteriology, 189 (19), 7105-7111. doi: 10.1128/JB.00681-07
The tubulin homologue FtsZ contributes to cell elongation by guiding cell wall precursor synthesis in Caulobacter crescentus

Aaron, Michelle, Charbon, Godefroid, Lam, Hubert, Schwarz, Heinz, Vollmer, Waldemar and Jacobs-Wagner, Christine (2007). The tubulin homologue FtsZ contributes to cell elongation by guiding cell wall precursor synthesis in Caulobacter crescentus. Molecular Microbiology, 64 (4), 938-952. doi: 10.1111/j.1365-2958.2007.05720.x
The prokaryotic cytoskeleton: a putative target for inhibitors and antibiotics?

Vollmer, Waldemar (2006). The prokaryotic cytoskeleton: a putative target for inhibitors and antibiotics?. Applied Microbiology and Biotechnology, 73 (1), 37-47. doi: 10.1007/s00253-006-0586-0
In vitro synthesis of cross-linked murein and its attachment to sacculi by PBP1A from Escherichia coli

Born, Petra, Breukink, Eefjan and Vollmer, Waldemar (2006). In vitro synthesis of cross-linked murein and its attachment to sacculi by PBP1A from Escherichia coli. Journal of Biological Chemistry, 281 (37), 26985-26993. doi: 10.1074/jbc.M604083200
Attenuation of penicillin resistance in a peptidoglycan O-acetyl transferase mutant of Streptococcus pneumoniae

Crisostomo, M. Ines, Vollmer, Waldemar, Kharat, Arun S., Inhuelsen, Silja, Gehre, Florian, Buckenmaier, Stephan and Tomasz, Alexander (2006). Attenuation of penicillin resistance in a peptidoglycan O-acetyl transferase mutant of Streptococcus pneumoniae. Molecular Microbiology, 61 (6), 1497-1509. doi: 10.1111/j.1365-2958.2006.05340.x
A functional dlt operon, encoding proteins required for incorporation of D-alanine in teichoic acids in gram-positive bacteria, confers resistance to cationic antimicrobial peptides in Streptococcus pneumoniae

Kovacs, Marta, Halfmann, Alexander, Fedtke, Iris, Heintz, Manuel, Peschel, Andreas, Vollmer, Waldemar, Hakenbeck, Regine and Brueckner, Reinhold (2006). A functional dlt operon, encoding proteins required for incorporation of D-alanine in teichoic acids in gram-positive bacteria, confers resistance to cationic antimicrobial peptides in Streptococcus pneumoniae. Journal of Bacteriology, 188 (16), 5797-5805. doi: 10.1128/JB.00336-06
Interaction between two murein (peptidoglycan) synthases, PBP3 and PBP1B, in Escherichia coli

Bertsche, Ute, Kast, Thomas, Wolf, Benoit, Fraipont, Claudine, Aarsman, Mirjam E. G., Kannenberg, Kai, von Rechenberg, Moritz, Nguyen-Disteche, Martine, den Blaauwen, Tanneke, Hoeltje, Joachim-Volker and Vollmer, Waldemar (2006). Interaction between two murein (peptidoglycan) synthases, PBP3 and PBP1B, in Escherichia coli. Molecular Microbiology, 61 (3), 675-690. doi: 10.1111/j.1365-2958.2006.05280.x
In vitro murein (peptidoglycan) synthesis by dimers of the bifunctional transglycosylase-transpeptidase PBP1B from Escherichia coli

Bertsche, Ute, Breukink, Eefjan, Kast, Thomas and Vollmer, Waldemar (2005). In vitro murein (peptidoglycan) synthesis by dimers of the bifunctional transglycosylase-transpeptidase PBP1B from Escherichia coli. Journal of Biological Chemistry, 280 (45), 38096-38101. doi: 10.1074/jbc.M508646200
Listeria monocytogenes EGD lacking penicillin-binding protein 5 (PBP5) produces a thicker cell wall

Korsak, Dorota, Vollmer, Waldemar and Markiewicz, Zdzislaw (2005). Listeria monocytogenes EGD lacking penicillin-binding protein 5 (PBP5) produces a thicker cell wall. FEMS Microbiology Letters, 251 (2), 281-288. doi: 10.1016/j.femsle.2005.08.009
Crystal structure of MltA from Escherichia coli reveals a unique lytic transglycosylase fold

van Straaten, Karin E., Dijkstra, Bauke W., Vollmer, Waldemar and Thunnissen, Andy-Mark W.H. (2005). Crystal structure of MltA from Escherichia coli reveals a unique lytic transglycosylase fold. Journal of Molecular Biology, 352 (5), 1068-1080. doi: 10.1016/j.jmb.2005.07.067
Susceptibility to antibiotics and beta-lactamase induction in murein hydrolase mutants of Escherichia coli

Korsak, Dorota, Liebscher, Sylvia and Vollmer, Waldemar (2005). Susceptibility to antibiotics and beta-lactamase induction in murein hydrolase mutants of Escherichia coli. Antimicrobial Agents and Chemotherapy, 49 (4), 1404-1409. doi: 10.1128/AAC.49.4.1404-1409.2005
Why are pathogenic staphylococci so lysozyme resistant? The peptidoglycan O-acetyltransferase OatA is the major determinant for lysozyme resistance of Staphylococcus aureus

Bera, Agnieszka, Herbert, Silvia, Jakob, Andreas, Vollmer, Waldemar and Gotz, Friedrich (2005). Why are pathogenic staphylococci so lysozyme resistant? The peptidoglycan O-acetyltransferase OatA is the major determinant for lysozyme resistance of Staphylococcus aureus. Molecular Microbiology, 55 (3), 778-787. doi: 10.1111/j.1365-2958.2004.04446.x
Murein (peptidoglycan) binding property of the essential cell division protein FtsN from Escherichia coli

Ursinus, Astrid, van den Ent, Fusinita, Brechtel, Sonja, de Pedro, Miguel, Holtje, Joachim-Volker, Lowe, Jan and Vollmer, Waldemar (2004). Murein (peptidoglycan) binding property of the essential cell division protein FtsN from Escherichia coli. Journal of Bacteriology, 186 (20), 6728-6737. doi: 10.1128/JB.186.20.6728-6737.2004
The architecture of the murein (peptidoglycan) in gram-negative bacteria: Vertical scaffold or horizontal layer(s)?

Vollmer, Waldemar and Holtje, Joachim-Volker (2004). The architecture of the murein (peptidoglycan) in gram-negative bacteria: Vertical scaffold or horizontal layer(s)?. Journal of Bacteriology, 186 (18), 5978-5987. doi: 10.1128/JB.186.18.5978-5987.2004
Overproduction of inactive variants of the murein synthase PBP1B causes lysis in Escherichia coli

Meisel, Ute, Holtje, Joachim-Volker and Vollmer, Waldemar (2003). Overproduction of inactive variants of the murein synthase PBP1B causes lysis in Escherichia coli. Journal of Bacteriology, 185 (18), 5342-5348. doi: 10.1128/JB.185.18.5342-5348.2003
Peptidoglycan N-acetylglucosamine deacetylase, a putative virulence factor in Streptococcus pneumoniae

Vollmer, Waldemar and Tomasz, Alexander (2002). Peptidoglycan N-acetylglucosamine deacetylase, a putative virulence factor in Streptococcus pneumoniae. Infection and Immunity, 70 (12), 7176-7178. doi: 10.1128/IAI.70.12.7176-7178.2002
Morphogenesis of Escherichia coli

Vollmer, Waldemar and Holtje, Joachim-Volker (2001). Morphogenesis of Escherichia coli. Current Opinion in Microbiology, 4 (6), 625-633. doi: 10.1016/S1369-5274(01)00261-2
Identification of the teichoic acid phosphorylcholine esterase in Streptococcus pneumoniae

Vollmer, Waldemar and Tomasz, Alexander (2001). Identification of the teichoic acid phosphorylcholine esterase in Streptococcus pneumoniae. Molecular Microbiology, 39 (6), 1610-1622. doi: 10.1046/j.1365-2958.2001.02349.x
The pgdA gene encodes for a peptidoglycan N-acetylglucosamine deacetylase in Streptococcus pneumoniae

Vollmer, Waldemar and Tomasz, Alexander (2000). The pgdA gene encodes for a peptidoglycan N-acetylglucosamine deacetylase in Streptococcus pneumoniae. Journal of Biological Chemistry, 275 (27), 20496-20501. doi: 10.1074/jbc.M910189199
A simple screen for murein transglycosylase inhibitors

Vollmer, Waldemar and Holtje, Joachim-Volker (2000). A simple screen for murein transglycosylase inhibitors. Antimicrobial Agents and Chemotherapy, 44 (5), 1181-1185. doi: 10.1128/AAC.44.5.1181-1185.2000
Demonstration of molecular interactions between the murein polymerase PBP1B, the lytic transglycosylase MltA, and the scaffolding protein MipA of Escherichia coli

Vollmer, Waldemar, von Rechenberg, Moritz and Holtje, Joachim-Volker (1999). Demonstration of molecular interactions between the murein polymerase PBP1B, the lytic transglycosylase MltA, and the scaffolding protein MipA of Escherichia coli. Journal of Biological Chemistry, 274 (10), 6726-6734. doi: 10.1074/jbc.274.10.6726
Outer membrane localization of murein hydrolases: MltA, a third lipoprotein lytic transglycosylase in Escherichia coli

Lommatzsch, J., Templin, M. F., Kraft, A. R., Vollmer, W. and Holtje, J. V. (1997). Outer membrane localization of murein hydrolases: MltA, a third lipoprotein lytic transglycosylase in Escherichia coli. Journal of Bacteriology, 179 (17), 5465-5470. doi: 10.1128/jb.179.17.5465-5470.1997
Pesticin displays muramidase activity

Vollmer, W., Pilsl, H., Hantke, K., Holtje, J. V. and Braun, V. (1997). Pesticin displays muramidase activity. Journal of Bacteriology, 179 (5), 1580-1583. doi: 10.1128/jb.179.5.1580-1583.1997
Characterization of three different lytic transglycosylases in Escherichia coli

Romeis, Tina, Vollmer, Waldemar and Höltje, Joachim-Volker (1993). Characterization of three different lytic transglycosylases in Escherichia coli. FEMS Microbiology Letters, 111 (2-3), 141-146. doi: 10.1111/j.1574-6968.1993.tb06376.x

PhD and MPhil Supervision

Current Supervision

Dissecting the bacterial cell envelope for antibiotic drug discovery

Doctor Philosophy — Principal Advisor
Other advisors:
- Professor Rob Capon
- Dr Nicholas Ariotti
Targeting bacterial cell envelope coordination for antibiotic drug discovery

Doctor Philosophy — Principal Advisor
Other advisors:
- Professor Brett Collins
Novel assays for antibiotic discovery

Doctor Philosophy — Principal Advisor
Other advisors:
- Professor Rob Capon

The University of Queensland

UQ Researchers