Harrison is a medicinal chemist with a research focus on bioactive peptides as therapeutics and molecular tools. He completed his Honours and PhD at UQ in the School of Chemistry and Molecular Biosciences where he developed synthetic peptide-based vaccine candidates against a range of targets including Group A Streptococcus and small molecule substances of abuse in the laboratory of Professor Istvan Toth. He is now a postdoctoral research fellow in the Muttenthaler group at IMB where he is involved in several programs of peptide-based drug discovery and pharmacological probe development.
Journal Article: Synthetic anti-cocaine nanoaccine successfully prevents cocaine-induced hyperlocomotion
Madge, Harrison Y. R., Alexander, Suzy, Azuar, Armira, Zhang, Jiahui, Koirala, Prashamsa, Burne, Thomas H., Toth, Istvan and Stephenson, Rachel J. (2023). Synthetic anti-cocaine nanoaccine successfully prevents cocaine-induced hyperlocomotion. Journal of Medicinal Chemistry, 66 (17), 12407-12419. doi: 10.1021/acs.jmedchem.3c00889
Other Outputs: Development of vaccine delivery systems for peptide antigens and small molecule haptens
Madge, Harrison (2022). Development of vaccine delivery systems for peptide antigens and small molecule haptens. PhD Thesis, School of Chemistry and Molecular Biosciences, The University of Queensland. doi: 10.14264/9869022
Journal Article: Poly(hydrophobic amino acids) and liposomes for delivery of vaccine against Group A Streptococcus
Azuar, Armira, Madge, Harrison Y. R., Boer, Jennifer C., Gonzalez Cruz, Jazmina L., Wang, Jingwen, Khalil, Zeinab G., Deceneux, Cyril, Goodchild, Georgia, Yang, Jieru, Koirala, Prashamsa, Hussein, Waleed M., Capon, Robert J., Plebanski, Magdalena, Toth, Istvan and Skwarczynski, Mariusz (2022). Poly(hydrophobic amino acids) and liposomes for delivery of vaccine against Group A Streptococcus. Vaccines, 10 (8) 1212, 1-14. doi: 10.3390/vaccines10081212
(2023–2025) Metro South Research Support Scheme Co-funded Collaboration Grant
Nanocarrier-based vaccine delivery systems for synthetic peptide vaccines
Madge, Harrison Y.R., Stephenson, Rachel J. and Toth, Istvan (2021). Nanocarrier-based vaccine delivery systems for synthetic peptide vaccines. Handbook of nanotechnology applications: environment, energy, agriculture and medicine. (pp. 509-535) edited by Woei Jye Lau, Kajornsak Faungnawakij, Kuakoon Piyachomkwan and Uracha Rungsardthong Ruktanonchai. Amsterdam, Netherlands: Elsevier. doi: 10.1016/b978-0-12-821506-7.00020-x
Synthetic anti-cocaine nanoaccine successfully prevents cocaine-induced hyperlocomotion
Madge, Harrison Y. R., Alexander, Suzy, Azuar, Armira, Zhang, Jiahui, Koirala, Prashamsa, Burne, Thomas H., Toth, Istvan and Stephenson, Rachel J. (2023). Synthetic anti-cocaine nanoaccine successfully prevents cocaine-induced hyperlocomotion. Journal of Medicinal Chemistry, 66 (17), 12407-12419. doi: 10.1021/acs.jmedchem.3c00889
Poly(hydrophobic amino acids) and liposomes for delivery of vaccine against Group A Streptococcus
Azuar, Armira, Madge, Harrison Y. R., Boer, Jennifer C., Gonzalez Cruz, Jazmina L., Wang, Jingwen, Khalil, Zeinab G., Deceneux, Cyril, Goodchild, Georgia, Yang, Jieru, Koirala, Prashamsa, Hussein, Waleed M., Capon, Robert J., Plebanski, Magdalena, Toth, Istvan and Skwarczynski, Mariusz (2022). Poly(hydrophobic amino acids) and liposomes for delivery of vaccine against Group A Streptococcus. Vaccines, 10 (8) 1212, 1-14. doi: 10.3390/vaccines10081212
Shalash, Ahmed O., Azuar, Armira, Madge, Harrison Y. R., Modhiran, Naphak, Amarilla, Alberto A., Liang, Benjamin, Khromykh, Alexander A., Hussein, Waleed M., Chappell, Keith J., Watterson, Daniel, Young, Paul R., Skwarczynski, Mariusz and Toth, Istvan (2022). Peptide-based vaccine against SARS-CoV-2: peptide antigen discovery and screening of adjuvant systems. Pharmaceutics, 14 (4) 856, 856. doi: 10.3390/pharmaceutics14040856
Huang, Wenbin, Madge, Harrison Y. R., Zhang, Jiahui, Gilmartin, Lachlan, Hussein, Waleed M., Khalil, Zeinab G., Koirala, Prashamsa, Capon, Robert J., Toth, Istvan and Stephenson, Rachel J. (2022). Structure-activity relationship of lipid, cyclic peptide and antigen rearrangement of physically mixed vaccines. International Journal of Pharmaceutics, 617 121614, 1-12. doi: 10.1016/j.ijpharm.2022.121614
Madge, Harrison Y. R., Huang, Wenbin, Gilmartin, Lachlan, Rigau-Planella, Berta, Hussein, Waleed M., Khalil, Zeinab G., Koirala, Prashamsa, Santiago, Viviene S., Capon, Robert J., Toth, Istvan and Stephenson, Rachel J. (2022). Physical mixture of a cyclic lipopeptide vaccine induced high titres of opsonic IgG antibodies against group A streptococcus. Biomaterials Science, 10 (1), 281-293. doi: 10.1039/d1bm01333e
Shalash, Ahmed O., Azuar, Armira, Madge, Harrison Y. R., Modhiran, Naphak, Amarilla, Alberto A., Liang, Benjamin, Khromykh, Alexander A., Watterson, Daniel, Young, Paul R., Toth, Istvan and Skwarczynski, Mariusz (2021). Detection and quantification of SARS-CoV-2 receptor binding domain neutralization by a sensitive competitive ELISA assay. Vaccines, 9 (12) 1493, 1-21. doi: 10.3390/vaccines9121493
Madge, Harrison Y. R., Sharma, Hansa, Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert John, Toth, Istvan and Stephenson, Rachel (2020). Structure–activity analysis of cyclic multicomponent lipopeptide self-adjuvanting vaccine candidates presenting Group A Streptococcus antigens. Journal of Medicinal Chemistry, 63 (10) acs.jmedchem.0c00203, 5387-5397. doi: 10.1021/acs.jmedchem.0c00203
Development of vaccine delivery systems for peptide antigens and small molecule haptens
Madge, Harrison (2022). Development of vaccine delivery systems for peptide antigens and small molecule haptens. PhD Thesis, School of Chemistry and Molecular Biosciences, The University of Queensland. doi: 10.14264/9869022
(2023–2025) Metro South Research Support Scheme Co-funded Collaboration Grant