The University of Queensland

Randomized trial on the effect of oral potassium chloride supplementation on the thiazide-sensitive sodium chloride cotransporter in healthy adults

Wu, Aihua, Wolley, Martin J., Mayr, Hannah L, Cheng, Lei, Cowley, Diane, Li, Bo, Campbell, Katrina L., Terker, Andrew S., Ellison, David H., Welling, Paul A., Fenton, Robert A. and Stowasser, Michael (2023). Randomized trial on the effect of oral potassium chloride supplementation on the thiazide-sensitive sodium chloride cotransporter in healthy adults. Kidney International Reports, 8 (6), 1201-1212. doi: 10.1016/j.ekir.2023.03.011

PS-BPC10-7: Effect of oral potassium chloride supplementation on the thiazide-sensitive sodium chloride cotransporter (NCC) in healthy humans: a randomised crossover trial

Wu, Aihua, Wolley, Martin, Mayr, Hannah, Cowley, Diane, Li, Bo, Welling, Paul, Campbell, Katrina, Fenton, Robert and Stowasser, Michael (2023). PS-BPC10-7: Effect of oral potassium chloride supplementation on the thiazide-sensitive sodium chloride cotransporter (NCC) in healthy humans: a randomised crossover trial. Journal of Hypertension, 41 (Suppl 1), e319-e320. doi: 10.1097/01.hjh.0000916000.37053.fa

Using human urinary extracellular vesicles to study physiological and pathophysiological states and regulation of the sodium chloride cotransporter

Wu, Aihua, Wolley, Martin J., Fenton, Robert A. and Stowasser, Michael (2022). Using human urinary extracellular vesicles to study physiological and pathophysiological states and regulation of the sodium chloride cotransporter. Frontiers in Endocrinology, 13 981317, 1-16. doi: 10.3389/fendo.2022.981317

In primary aldosteronism acute potassium chloride supplementation suppresses abundance and phosphorylation of the sodium-chloride cotransporter

Wu, Aihua, Wolley, Martin J., Matthews, Alexandra, Cowley, Diane, Welling, Paul A., Fenton, Robert A. and Stowasser, Michael (2022). In primary aldosteronism acute potassium chloride supplementation suppresses abundance and phosphorylation of the sodium-chloride cotransporter. Kidney360, 3 (11), 1909-1923. doi: 10.34067/kid.0003632022

Acute intravenous NaCl and volume expansion reduces NCC abundance and phosphorylation in urinary extracellular vesicles

Wu, Aihua, Wolley, Martin J., Wu, Qi, Cowley, Diane, Palmfeldt, Johan, Welling, Paul A., Fenton, Robert A. and Stowasser, Michael (2022). Acute intravenous NaCl and volume expansion reduces NCC abundance and phosphorylation in urinary extracellular vesicles. Kidney360, 3 (5), 910-921. doi: 10.34067/kid.0000362022

The Cl−/HCO3− exchanger pendrin is downregulated during oral co-administration of exogenous mineralocorticoid and KCl in patients with primary aldosteronism

Wu, Aihua, Wolley, Martin J., Wu, Qi, Gordon, Richard D., Fenton, Robert A. and Stowasser, Michael (2020). The Cl−/HCO3− exchanger pendrin is downregulated during oral co-administration of exogenous mineralocorticoid and KCl in patients with primary aldosteronism. Journal of Human Hypertension, 35 (10), 837-848. doi: 10.1038/s41371-020-00439-7

Pathogenesis of familial hyperaldosteronism type II: new concepts involving anion channels

Stowasser, Michael, Wolley, Martin, Wu, Aihua, Gordon, Richard D., Schewe, Julia, Stoelting, Gabriel and Scholl, Ute I. (2019). Pathogenesis of familial hyperaldosteronism type II: new concepts involving anion channels. Current Hypertension Reports, 21 (4) 31, 31. doi: 10.1007/s11906-019-0934-y

The interplay of renal potassium and sodium handling in blood pressure regulation: critical role of the WNK-SPAK-NCC pathway

Wu, Aihua, Wolley, Martin and Stowasser, Michael (2019). The interplay of renal potassium and sodium handling in blood pressure regulation: critical role of the WNK-SPAK-NCC pathway. Journal of Human Hypertension, 33 (7), 508-523. doi: 10.1038/s41371-019-0170-6

A7813 Variations in abundance of urinary exosomal renal sodium transporters in response to mineralocorticoid administration and oral salt loading and in relation to baseline plasma aldosterone and potassium

Wu, Aihua, Wolley, Martin, Xu, Shengxin, Gordon, Richard, Fenton, Robert and Stowasser, Michael (2018). A7813 Variations in abundance of urinary exosomal renal sodium transporters in response to mineralocorticoid administration and oral salt loading and in relation to baseline plasma aldosterone and potassium. Journal of Hypertension, 36, e35. doi: 10.1097/01.hjh.0000548130.69597.05

CLCN2 chloride channel mutations in familial hyperaldosteronism type II

Scholl, Ute I., Stölting, Gabriel, Schewe, Julia, Thiel, Anne, Tan, Hua, Nelson-Williams, Carol, Vichot, Alfred A., Jin, Sheng Chih, Loring, Erin, Untiet, Verena, Yoo, Taekyeong, Choi, Jungmin, Xu, Shengxin, Wu, Aihua, Kirchner, Marieluise, Mertins, Philipp, Rump, Lars C., Onder, Ali Mirza, Gamble, Cory, McKenney, Daniel, Lash, Robert W., Jones, Deborah P., Chune, Gary, Gagliardi, Priscila, Choi, Murim, Gordon, Richard, Stowasser, Michael, Fahlke, Christoph and Lifton, Richard P. (2018). CLCN2 chloride channel mutations in familial hyperaldosteronism type II. Nature Genetics, 50 (3), 1-6. doi: 10.1038/s41588-018-0048-5

In primary aldosteronism, mineralocorticoids influence exosomal sodium-chloride cotransporter abundance

Wolley, Martin J., Wu, Aihua, Xu, Shengxin, Gordon, Richard D., Fenton, Robert A. and Stowasser, Michael (2017). In primary aldosteronism, mineralocorticoids influence exosomal sodium-chloride cotransporter abundance. Journal of the American Society of Nephrology, 28 (1), 56-63. doi: 10.1681/ASN.2015111221

OS 05-06 IN PRIMARY ALDOSTERONISM, MINERALOCORTICOIDS AND POTASSIUM INFLUENCE ABUNDANCE OF THE THIAZIDE SENSITIVE SODIUM-CHLORIDE COTRANSPORTER

MJ, Wolley, A, Wu, S, Xu, RD, Gordon, RA, Fenton and M, Stowasser (2016). OS 05-06 IN PRIMARY ALDOSTERONISM, MINERALOCORTICOIDS AND POTASSIUM INFLUENCE ABUNDANCE OF THE THIAZIDE SENSITIVE SODIUM-CHLORIDE COTRANSPORTER. Journal of Hypertension, 34 (Supplement 1), e59. doi: 10.1097/01.hjh.0000500006.71928.56

PP.LB03.01 : MINERALOCORTICOID RECEPTOR ACTIVATION ACUTELY INCREASES EXPRESSION AND PHOSPHORYLATION OF THE THIAZIDE SENSITIVE SODIUM CHLORIDE COTRANSPORTER IN HUMANS

Wolley, M., Wu, A., Xu, S., Gordon, R., Fenton, R. and Stowasser, M. (2015). PP.LB03.01 : MINERALOCORTICOID RECEPTOR ACTIVATION ACUTELY INCREASES EXPRESSION AND PHOSPHORYLATION OF THE THIAZIDE SENSITIVE SODIUM CHLORIDE COTRANSPORTER IN HUMANS. Journal of Hypertension, 33 (Supplement 1), e517. doi: 10.1097/01.hjh.0000469019.86750.dd

Pre-coating layered double hydroxide nanoparticles with albumin to improve colloidal stability and cellular uptake

Gu, Zi, Zuo, Hualia, Li, Li, Wu, Aihua and Xu, Zhi Ping (2015). Pre-coating layered double hydroxide nanoparticles with albumin to improve colloidal stability and cellular uptake. Journal of Materials Chemistry B, 3 (16), 3331-3339. doi: 10.1039/c5tb00248f

Influence of hydrothermal treatment on physicochemical properties and drug release of anti-inflammatory drugs of intercalated layered double hydroxide nanoparticles

Gu, Zi, Wu, Aihua, Li, Li and Xu, Zhi Ping (2014). Influence of hydrothermal treatment on physicochemical properties and drug release of anti-inflammatory drugs of intercalated layered double hydroxide nanoparticles. Pharmaceutics, 6 (2), 235-248. doi: 10.3390/pharmaceutics6020235

Reduced NACL cotransporter abundance and phosphorylation in urinary extracellular vesicles in response to kcl supplements in healthy adults maintained on a high-Na+ low-K+ diet: A

Wu, Aihua, Wolley, Martin, Mayr, Hannah, Cowley, Diane, Li, Bo, Welling, Paul, Campbell, Katrina, Fenton, Robert and Stowasser, Michael (2022). Reduced NACL cotransporter abundance and phosphorylation in urinary extracellular vesicles in response to kcl supplements in healthy adults maintained on a high-Na+ low-K+ diet: A. ESH 2022, 31st European Meeting on Hypertension and Cardiovascular Protection, 17-20 June 2022. Philadelphia, PA USA: Lippincott Williams & Wilkins. doi: 10.1097/01.hjh.0000835336.87224.dd

Pendrin reduction is associated with acute intravenous sodium chloride loading in patients with primary aldosteronism

Wu, Aihua, Wolley, Martin J., Wu, Qi, Cowley, Diane, Gordon, Richard D., Fenton, Robert A. and Stowasser, Michael (2021). Pendrin reduction is associated with acute intravenous sodium chloride loading in patients with primary aldosteronism. Joint Meeting ESH-ISH 2021, Glasgow, Scotland, United Kingdom, 11-14 April 2021. Philadelphia, PA USA: Lippincott Williams & Wilkins. doi: 10.1097/01.hjh.0000744712.11686.f1

Administration of exogenous mineralocorticoids and potassium is associated with a reduction in pendrin abundance in urinary exosomes from patients with primary aldosteronisms

Wu, A., Wolley, M. J., Wu, Q., Gordon, R. D., Fenton, R. A. and Stowasser, M. (2019). Administration of exogenous mineralocorticoids and potassium is associated with a reduction in pendrin abundance in urinary exosomes from patients with primary aldosteronisms. 29th European Meeting of Hypertension and Cardiovascular Protection of the European Society of Hypertension (ESH), Milan, Italy, 21-24 June, 2019. Philadelphia, PA, United States: Lippincott Williams and Wilkins. doi: 10.1097/01.hjh.0000572804.12495.d9

Effects of acute sodium loading on NCC abundance and phosphorylation in hypertensives with raised aldosterone to renin ratio (ARR) in human urinary exosomes

Wu, A., Wolley, M. J., Cowley, D., Gordon, R. D., Fenton, R. A. and Stowasser, M. (2019). Effects of acute sodium loading on NCC abundance and phosphorylation in hypertensives with raised aldosterone to renin ratio (ARR) in human urinary exosomes. 29th European Meeting of Hypertension and Cardiovascular Protection of the European Society of Hypertension (ESH), Milan, Italy, 21-24June, 2019. Philadelphia, PA, United States: Lippincott Williams and Wilkins. doi: 10.1097/01.hjh.0000572808.89624.7a

[BP.12.02] Plasma potassium negatively effects abundance of the thaizide sensitive sodium-chloride cotransporter in humans

Wolley, M., Wu, A., Gordon, R. D., Fenton, R. and Stowasser, M. (2017). [BP.12.02] Plasma potassium negatively effects abundance of the thaizide sensitive sodium-chloride cotransporter in humans. 27th European Meeting on Hypertension and Cardiovascular Protection, Milan, Italy, 16-19 July 2017. Philadelphia, PA USA: Lippincott Williams & Wilkins. doi: 10.1097/01.hjh.0000524034.63874.af

Plasma potassium negatively effects abundance of the thaizide sensitive sodium-chloride cotransporter in humans

Wolley, M., Wu, A., Gordon, R. D., Fenton, R. A. and Stowasser, M. (2017). Plasma potassium negatively effects abundance of the thaizide sensitive sodium-chloride cotransporter in humans. 38th Annual Scientific Meeting of the High Blood Pressure Research Council of Australia, Hobart, Australia, 7-10 December 2017. Philadelphia, PA, United States: Lippincott Williams & Wilkins.

Quantitative mRNA analysis of the thiazide-sensitive sodium chloride cotransporters in urinary exosomes from normal controls and patients with primary aldosteronism

Wu, A., Wolley, M. J., Xu, S., Gordon, R. D. and Stowasser, M. (2017). Quantitative mRNA analysis of the thiazide-sensitive sodium chloride cotransporters in urinary exosomes from normal controls and patients with primary aldosteronism. 38th Annual Scientific Meeting of the High Blood Pressure Research Council of Australia, Hobart, Australia, 7-10 December 2017. Philadelphia, PA, United States: Lippincott Williams & Wilkins.

PS 02-33 quantitative mRNA analysis of thiazide sodium cotransporter in urinary exosomes from normal controls and patients with primary aldosteronism

WU, Aihua, Wolley, Martin, Xu, Shengxin, Gordon, Richard and Stowasser, Michael (2016). PS 02-33 quantitative mRNA analysis of thiazide sodium cotransporter in urinary exosomes from normal controls and patients with primary aldosteronism. 26th Scientific Meeting of the International Society of Hypertension, Seoul, South Korea, 24-26 September 2016. Philadelphia, PA USA: Lippincott Williams & Wilkins. doi: 10.1097/01.hjh.0000500161.62149.61

Mineralocorticoids increase abundance and phosphorylation of the thiazide sensitive sodium-chloride cotransporter in humans via the WNK-SPAK pathway

Wolley, M. J., Wu, A., Xu, S., Gordon, R. D., Fenton, R. A. and Stowasser, M. (2016). Mineralocorticoids increase abundance and phosphorylation of the thiazide sensitive sodium-chloride cotransporter in humans via the WNK-SPAK pathway. 37th Annual Scientific Meeting of the High Blood Pressure Research Council of Australia (HBPRCA), Melbourne, Australia, 2-4 December 2015. Philadelphia, PA, United States: Lippincott Williams & Wilkins.

Mineralocorticoid receptor activation acutely increases expression and phosphorylation of the thiazide sensitive sodium chloride cotransporter in humans

Wolley, M., Wu, A., Xu, S., Gordon, R., Fenton, R. and Stowasser, M. (2015). Mineralocorticoid receptor activation acutely increases expression and phosphorylation of the thiazide sensitive sodium chloride cotransporter in humans. 51st Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Canberra, Australia, 7-9 September 2015. Richmond, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/nep.12549

Stabilization of layered double hydroxide nanoparticles by bovine serum albumin pre-coating for drug/gene delivery

Gu, Zi, Zuo, Huali, Wu, Aihua and Xu, Zhi Ping (2015). Stabilization of layered double hydroxide nanoparticles by bovine serum albumin pre-coating for drug/gene delivery. SIPCD 2014, Suzhou Peoples R China, 16-19 September 2014. Amsterdam, The Netherlands: Elsevier. doi: 10.1016/j.jconrel.2015.05.255

Regulation of sodium chloride cotransporter (NCC) in health and disease

Wu, Aihua (2022). Regulation of sodium chloride cotransporter (NCC) in health and disease. PhD Thesis, The University of Queensland Diamantina Institute, The University of Queensland. doi: 10.14264/818c80d