Dr Halley Ravuri

Postdoctoral Research Fellow

School of Biomedical Sciences
Faculty of Medicine

Overview

Dr. Halley Ravuri completed his Bachelor of Veterinary Science degree from the Orissa University of Agriculture and Technology, and a Master in Pharmacology and Toxicology from the Birsa Agricultural University, India. He recently finished his PhD in Veterinary Science at UQ in 2022. Before his PhD, he worked as a Research Associate in various research organizations for four years in India. His primary research was focused on developing cancer models for glioma (brain cancer), breast cancer, and melanoma in laboratory rodents, and investigating the efficacy of nano-particulated anticancer compounds. He is very experienced in maintaining, experimenting on laboratory rodents and has hands-on experience in research methodologies including ELISA, PCR, western blot analysis, histopathology, and bioanalytical analysis using HPLC instrumentation

His doctoral research was focused on transdermal drug delivery of nonsteroidal anti-inflammatory drugs (NSAIDs) in veterinary species and evaluating the efficacy of novel transdermal formulations using mass spectrometry-based plasma proteomics and lipidomics. He has garnered tremendous interest and expertise in the use of advanced mass spectrometry instruments including LC-MS/MS, GC-MS, and LC-TOF-MS, for enabling both targeted and discovery analysis of proteins, drugs, and lipid metabolites in animal plasma/serum. He has also worked as a technical assistant at the Analytical Service Unit, School of Agriculture and Food Sciences, UQ, using mass spectrometry for the analysis of pesticides, and fatty acid composition in milk, soils, and food samples.

Dr. Halley Ravuri recently commenced at The School of Biomedical Sciences, Faculty of Medicine, UQ – as a Postdoctoral Research Fellow, under the supervision of Prof. Mark Midwinter. His current research goals are to characterize endothelial glycocalyx metabolites in serum/plasma using advanced mass spectrometry techniques, and also explore the pathophysiology of trauma and hemorrhagic shock using a proteomics-based approach. He also has a keen interest in exploring alternative in-vitro techniques to investigate endothelial glycocalyx, and examining the role of exosomes in trauma/hemorrhagic shock in animals and humans. His long-term goal is to establish himself as a translational proteomics expert in the field of plasma biomarker discovery and establish novel mass spectrometry methods and data analysis pipelines to improve the application of mass spectrometry research in the veterinary and translation biomedical sciences. He is an advocate of the use of mass spectrometry-based proteomics to contribute to the field of “One Health”; using veterinary species as translational models for studying human diseases. His future research goals include exploring viral proteomics to investigate and understand the virulence of viruses, characterise viral antibodies using mass spectrometry and studying physiological responses in animals, humans, and model organisms.

Research Interests

  • Mass spectrometry-based plasma proteomics, especially DIA mass spectrometry
  • Mass spectrometry-based plasma metabolomic and lipidomic analysis
  • In-vitro characterisation of endothelial cell-lines for studying role of glycocalyx
  • Investigating role of exosomes and microvescicles in trauma and shock

Qualifications

  • Doctor of Philosophy of Veterinary Science, The University of Queensland
  • Masters (Research) of Veterinary Pharmacology, Birsa Agricultural University
  • Bachelor of Veterinary Sciences, Orissa University of Agriculture and Technology

Publications

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Supervision

  • Doctor Philosophy

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Publications

Journal Article

Conference Publication

Other Outputs

PhD and MPhil Supervision

Current Supervision