The University of Queensland

SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice

Alhammad, Yousef M., Parthasarathy, Srivatsan, Ghimire, Roshan, Kerr, Catherine M., O’Connor, Joseph J., Pfannenstiel, Jessica J., Chanda, Debarati, Miller, Caden A., Baumlin, Nathalie, Salathe, Matthias, Unckless, Robert L., Zuñiga, Sonia, Enjuanes, Luis, More, Sunil, Channappanavar, Rudragouda and Fehr, Anthony R. (2023). SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice. Proceedings of the National Academy of Sciences, 120 (35). doi: 10.1073/pnas.2302083120

Full-length genome of the equine influenza A virus subtype H3N8 from 2019 outbreak in Saudi Arabia

Alaql, Fanan A., Alhafufi, Ali N., Kasem, Samy, Alhammad, Yousef M. O., Albaqshi, Hassan, Alyousaf, Ameen, Alsubaie, Faisal M., Alghamdi, Ahmed N., Abdel-Moneim, Ahmed S. and Alharbi, Sulaiman A. (2022). Full-length genome of the equine influenza A virus subtype H3N8 from 2019 outbreak in Saudi Arabia. Animals, 12 (19) 2720, 1-13. doi: 10.3390/ani12192720

Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening

Roy, Anu, Alhammad, Yousef M., McDonald, Peter, Johnson, David K., Zhuo, Junlin, Wazir, Sarah, Ferraris, Dana, Lehtiö, Lari, Leung, Anthony K.L. and Fehr, Anthony R. (2022). Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening. Antiviral Research, 203 105344, 105344. doi: 10.1016/j.antiviral.2022.105344

Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity

Heer, Collin D., Sanderson, Daniel J., Voth, Lynden S., Alhammad, Yousef M.O., Schmidt, Mark S., Trammell, Samuel A.J., Perlman, Stanley, Cohen, Michael S., Fehr, Anthony R. and Brenner, Charles (2020). Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity. Journal of Biological Chemistry, 295 (52), 17986-17996. doi: 10.1074/jbc.ra120.015138

The viral macrodomain counters host antiviral ADP-Ribosylation

Alhammad, Yousef M. O. and Fehr, Anthony R. (2020). The viral macrodomain counters host antiviral ADP-Ribosylation. Viruses, 12 (4) 384. doi: 10.3390/v12040384

Escape of hepatitis C virus from epitope I neutralization increases sensitivity of other neutralization epitopes

Gu, Jun, Hardy, Joshua, Boo, Irene, Vietheer, Patricia, McCaffrey, Kathleen, Alhammad, Yousef, Chopra, Abha, Gaudieri, Silvana, Poumbourios, Pantelis, Coulibaly, Fasséli and Drummer, Heidi E. (2018). Escape of hepatitis C virus from epitope I neutralization increases sensitivity of other neutralization epitopes. Journal of Virology, 92 (9) e02066-17, 1-18. doi: 10.1128/jvi.02066-17

Monoclonal Antibodies Directed toward the Hepatitis C Virus Glycoprotein E2 Detect Antigenic Differences Modulated by the N-Terminal Hypervariable Region 1 (HVR1), HVR2, and Intergenotypic Variable Region

Alhammad, Yousef, Gu, Jun, Boo, Irene, Harrison, David, McCaffrey, Kathleen, Vietheer, Patricia T., Edwards, Stirling, Quinn, Charles, Coulibaly, Fásseli, Poumbourios, Pantelis and Drummer, Heidi E. (2015). Monoclonal Antibodies Directed toward the Hepatitis C Virus Glycoprotein E2 Detect Antigenic Differences Modulated by the N-Terminal Hypervariable Region 1 (HVR1), HVR2, and Intergenotypic Variable Region. Journal of Virology, 89 (24), 12245-12261. doi: 10.1128/jvi.02070-15

Longitudinal Sequence and Functional Evolution within Glycoprotein E2 in Hepatitis C Virus Genotype 3a Infection

Alhammad, Yousef M. O., Maharajh, Sanvir, Butcher, Rebecca, Eden, John-Sebastian, White, Peter A., Poumbourios, Pantelis and Drummer, Heidi E (2015). Longitudinal Sequence and Functional Evolution within Glycoprotein E2 in Hepatitis C Virus Genotype 3a Infection. PLOS ONE, 10 (5), e0126397. doi: 10.1371/journal.pone.0126397