Research Officer
Overview
Nanotechnology revolutionizes the trends in biomedical applications. In particular, nanomaterial-based cancer treatment and immunotherapy are hot topics of interest. By paying attention to the molecular-level details of cancer as well as the changes in the tumor microenvironment, novel nanoparticles can be designed (for example: for in-situ capture of generated tumour associated antigens (TAA) and for the regulation of macrophage phenotypes) for treating cancer. Oral delivery of nanotherapeutics and nanovaccine is another topic of broad interest that can maximize patient comfort, reduce medical expenses and reduce complications in administration. In this regard, nanomaterials can be carefully designed to overcome the challenges in the oral delivery of drugs, adjuvants, and genetic materials. Cutting-edge nanotechnology and nanochemistry are combined to develop silica-based delivery systems for cancer vaccines or cancer treatment.
Shevanuja Theivendran finished her bachelor's degree in Chemical Engineering at the University of Mississippi, USA, with 3 years of research experience in synthesizing and characterizing Gold Nanomaterials. During her bachelor's degree, she got a wonderful opportunity to associate with a world-leading expert in the field of crystallization, Prof. Allan Myerson from Massachusetts Institute of Technology, Boston, USA, as a research intern. She was also awarded Taylor Medal in 2016, the university's highest academic award which is awarded as a recognition for her meritorious studies. Thereafter, she got admitted to the Ph.D. program at UQ with the prestigious RTP scholarship in 2018. Shevanuja did her Ph.D. under the supervision of Prof. Chengzhong Yu, Australian Institute for Bioengineering and Nanotechnology (AIBN), focusing on the design of nanoparticles for the capture and delivery of in-situ generated tumour associated antigens (TAA) and the regulation of tumor microenvironment for cancer immunotherapy. She is currently working as a post-doctoral research fellow at AIBN, the University of Queensland. Her current research focuses on the development of nanomaterial-based oral DNA vaccine in collaboration with N4 Pharma and the development of novel nanoplatforms for the regulation of tumor microenvironment by targeting different components of cancer and its microenvironment for cancer treatment.
Publications
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Journal Article: Mesoporous silica/organosilica nanoparticles for cancer immunotherapy
Theivendran, Shevanuja, Lazarev, Sergei and Yu, Chengzhong (2023). Mesoporous silica/organosilica nanoparticles for cancer immunotherapy. Exploration, 3 (3) 20220086, 20220086. doi: 10.1002/exp.20220086
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Journal Article: Surface chemistry of spiky silica nanoparticles tailors polyethyleneimine binding and intracellular DNA delivery
Cheng, Dan, Theivendran, Shevanuja, Tang, Jie, Cai, Larry, Zhang, Jun, Song, Hao and Yu, Chengzhong (2022). Surface chemistry of spiky silica nanoparticles tailors polyethyleneimine binding and intracellular DNA delivery. Journal of Colloid and Interface Science, 628 (Part B), 297-305. doi: 10.1016/j.jcis.2022.08.038
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Journal Article: Mesoporous sodium four-coordinate aluminosilicate nanoparticles modulate dendritic cell pyroptosis and activate innate and adaptive immunity
Tang, Jie, Yang, Yang, Qu, Jingjing, Ban, Wenhuang, Song, Hao, Gu, Zhengying, Yang, Yannan, Cai, Larry, Theivendran, Shevanuja, Wang, Yue, Zhang, Min and Yu, Chengzhong (2022). Mesoporous sodium four-coordinate aluminosilicate nanoparticles modulate dendritic cell pyroptosis and activate innate and adaptive immunity. Chemical Science, 13 (29), 8507-8517. doi: 10.1039/d1sc05319a
Supervision
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Developing a versatile platform for sensitive detection of small molecules
Doctor Philosophy
Publications
Journal Article
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Mesoporous silica/organosilica nanoparticles for cancer immunotherapy
Theivendran, Shevanuja, Lazarev, Sergei and Yu, Chengzhong (2023). Mesoporous silica/organosilica nanoparticles for cancer immunotherapy. Exploration, 3 (3) 20220086, 20220086. doi: 10.1002/exp.20220086
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Cheng, Dan, Theivendran, Shevanuja, Tang, Jie, Cai, Larry, Zhang, Jun, Song, Hao and Yu, Chengzhong (2022). Surface chemistry of spiky silica nanoparticles tailors polyethyleneimine binding and intracellular DNA delivery. Journal of Colloid and Interface Science, 628 (Part B), 297-305. doi: 10.1016/j.jcis.2022.08.038
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Tang, Jie, Yang, Yang, Qu, Jingjing, Ban, Wenhuang, Song, Hao, Gu, Zhengying, Yang, Yannan, Cai, Larry, Theivendran, Shevanuja, Wang, Yue, Zhang, Min and Yu, Chengzhong (2022). Mesoporous sodium four-coordinate aluminosilicate nanoparticles modulate dendritic cell pyroptosis and activate innate and adaptive immunity. Chemical Science, 13 (29), 8507-8517. doi: 10.1039/d1sc05319a
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Theivendran, Shevanuja, Gu, Zhengying, Tang, Jie, Yang, Yannan, Song, Hao, Yang, Yang, Zhang, Min, Cheng, Dan and Yu, Chengzhong (2022). Nanostructured organosilica nitric oxide donors intrinsically regulate macrophage polarization with antitumor effect. ACS Nano, 16 (7), 10943-10957. doi: 10.1021/acsnano.2c03348
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Theivendran, Shevanuja and Yu, Chengzhong (2021). Nanochemistry modulates intracellular decomposition routes of S‐nitrosothiol modified silica‐based nanoparticles. Small, 17 (21) 2007671, 1-6. doi: 10.1002/smll.202007671
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Nanotechnology enabled reactive species regulation in biosystems for boosting cancer immunotherapy
Zhang, Min, Dai, Zan, Theivendran, Shevanuja, Gu, Zhengying, Zhao, Liang, Song, Hao, Yang, Yannan and Yu, Chengzhong (2021). Nanotechnology enabled reactive species regulation in biosystems for boosting cancer immunotherapy. Nano Today, 36 101035, 1-18. doi: 10.1016/j.nantod.2020.101035
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Tang, Jie, Meka, Anand Kumar, Theivendran, Shevanuja, Wang, Yue, Yang, Yannan, Song, Hao, Fu, Jianye, Ban, Wenhuang, Gu, Zhengying, Lei, Chang, Li, Shumin and Yu, Chengzhong (2020). Openwork@Dendritic mesoporous silica nanoparticles for lactate depletion and tumor microenvironment regulation. Angewandte Chemie International Edition, 59 (49) anie.202001469, 22054-22062. doi: 10.1002/anie.202001469
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Post translational modification-assisted cancer immunotherapy for effective breast cancer treatment
Theivendran, Shevanuja, Tang, Jie, Lei, Chang, Yang, Yannan, Song, Hao, Gu, Zhengying, Wang, Yue, Yang, Yang, Jin, Lei and Yu, Chengzhong (2020). Post translational modification-assisted cancer immunotherapy for effective breast cancer treatment. Chemical Science, 11 (38), 10421-10430. doi: 10.1039/d0sc02803g
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Theivendran, Shevanuja, Zhang, Jun, Tang, Cheng, Kalantari, Mohammad, Gu, Zhengying, Yang, Yannan, Yang, Yang, Strounina, Ekaterina, Du, Aijun and Yu, Chengzhong (2019). Synthesis of biphenyl bridged dendritic mesoporous organosilica with extremely high adsorption of pyrene. Journal of Materials Chemistry A, 7 (19), 12029-12037. doi: 10.1039/c9ta01281h
Other Outputs
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Developing Functionalised Mesoporous Silica Nanoparticles for Cancer Treatment
Theivendran, Shevanuja (2022). Developing Functionalised Mesoporous Silica Nanoparticles for Cancer Treatment. PhD Thesis, Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland.
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Developing Functionalised Mesoporous Silica Nanoparticles for Cancer Treatment
Theivendran, Shevanuja (2022). Developing Functionalised Mesoporous Silica Nanoparticles for Cancer Treatment. PhD Thesis, Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland.
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Developing Functionalised Mesoporous Silica Nanoparticles for Cancer Treatment
Theivendran, Shevanuja (2021). Developing Functionalised Mesoporous Silica Nanoparticles for Cancer Treatment. PhD Thesis, Australian Institute for Bioengineering & Nanotechnology, The University of Queensland.
PhD and MPhil Supervision
Current Supervision
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Developing a versatile platform for sensitive detection of small molecules
Doctor Philosophy — Associate Advisor
Other advisors:
