The University of Queensland

Multifunctional Fluoropolymer‐Engineered Magnetic Nanoparticles to Facilitate Blood‐Brain Barrier Penetration and Effective Gene Silencing in Medulloblastoma

Forgham, Helen, Zhu, Jiayuan, Huang, Xumin, Zhang, Cheng, Biggs, Heather, Liu, Liwei, Wang, Yi Cheng, Fletcher, Nicholas, Humphries, James, Cowin, Gary, Mardon, Karine, Kavallaris, Maria, Thurecht, Kristofer, Davis, Thomas P. and Qiao, Ruirui (2024). Multifunctional Fluoropolymer‐Engineered Magnetic Nanoparticles to Facilitate Blood‐Brain Barrier Penetration and Effective Gene Silencing in Medulloblastoma. Advanced Science. doi: 10.1002/advs.202401340

Fluorine-modified polymers reduce the adsorption of immune-reactive proteins to PEGylated gold nanoparticles

Forgham, Helen, Zhu, Jiayuan, Zhang, Taoran, Huang, Xumin, Li, Xiangke, Shen, Ao, Biggs, Heather, Talbo, Gert, Xu, Chun, Davis, Thomas P and Qiao, Ruirui (2024). Fluorine-modified polymers reduce the adsorption of immune-reactive proteins to PEGylated gold nanoparticles. Nanomedicine. doi: 10.2217/nnm-2023-0357

Nanoengineering liquid metal core–shell nanostructures

Lu, Hongda, Tang, Shi‐Yang, Zhu, Jiayuan, Huang, Xumin, Forgham, Helen, Li, Xiangke, Shen, Ao, Yun, Guolin, Hu, Jinming, Zhang, Shiwu, Davis, Thomas P., Li, Weihua and Qiao, Ruirui (2024). Nanoengineering liquid metal core–shell nanostructures. Advanced Functional Materials, 34 (6) 2311300. doi: 10.1002/adfm.202311300

Tailored fluorosurfactants through controlled/living radical polymerization for highly stable microfluidic droplet generation

Li, Xiangke, Tang, Shi‐Yang, Zhang, Yang, Zhu, Jiayuan, Forgham, Helen, Zhao, Chun‐Xia, Zhang, Cheng, Davis, Thomas P. and Qiao, Ruirui (2024). Tailored fluorosurfactants through controlled/living radical polymerization for highly stable microfluidic droplet generation. Angewandte Chemie, 136 (3) e202315552, 1-9. doi: 10.1002/ange.202315552

Tailored fluorosurfactants through controlled/living radical polymerization for highly stable microfluidic droplet generation

Li, Xiangke, Tang, Shi-Yang, Zhang, Yang, Zhu, Jiayuan, Forgham, Helen, Zhao, Chun-Xia, Zhang, Cheng, Davis, Thomas P. and Qiao, Ruirui (2023). Tailored fluorosurfactants through controlled/living radical polymerization for highly stable microfluidic droplet generation. Angewandte Chemie International Edition, 63 (3) e202315552, e202315552. doi: 10.1002/anie.202315552

Antifouling surface coatings for the next generation of nanomedicine: toward <i>in vivo</i> immune evasion

Forgham, Helen, Liu, Liwei, Davis, Thomas P and Qiao, Ruirui (2023). Antifouling surface coatings for the next generation of nanomedicine: toward in vivo immune evasion. Nanomedicine, 1997-2000. doi: 10.2217/nnm-2023-0316

Alzheimer's progenitor amyloid‐β targets and dissolves microbial amyloids and impairs biofilm function

Ali, Syed Aoun, Chung, Ka Hang Karen, Forgham, Helen, Olsen, William P., Kakinen, Aleksandr, Balaji, Arunpandian, Otzen, Daniel E., Davis, Thomas Paul and Javed, Ibrahim (2023). Alzheimer's progenitor amyloid‐β targets and dissolves microbial amyloids and impairs biofilm function. Advanced Science, 10 (29) 2301423, e2301423. doi: 10.1002/advs.202301423

Vector enabled CRISPR gene editing – A revolutionary strategy for targeting the diversity of brain pathologies

Forgham, Helen, Liu, Liwei, Zhu, Jiayuan, Javed, Ibrahim, Cai, Weibo, Qiao, Ruirui and Davis, Thomas P. (2023). Vector enabled CRISPR gene editing – A revolutionary strategy for targeting the diversity of brain pathologies. Coordination Chemistry Reviews, 487 215172. doi: 10.1016/j.ccr.2023.215172

Magnetic iron oxide nanoparticles for brain imaging and drug delivery

Qiao, Ruirui, Fu, Changkui, Forgham, Helen, Javed, Ibrahim, Huang, Xumin, Zhu, Jiayuan, Whittaker, Andrew K. and Davis, Thomas P. (2023). Magnetic iron oxide nanoparticles for brain imaging and drug delivery. Advanced Drug Delivery Reviews, 197 114822, 1-31. doi: 10.1016/j.addr.2023.114822

Dual-ratiometric magnetic resonance tunable nanoprobe with acidic-microenvironment-responsive property to enhance the visualization of early tumor pathological changes

Cao, Rong, Tang, Ning, Zhu, Yi, Chen, An, Li, Yumeng, Ge, Renbin, Li, Yuan, Huang, Zhongyi, Guo, Jiajing, Deng, Jiali, Lu, Hongwei, Lu, Ziwei, Forgham, Helen, Davis, Thomas P., Qiao, Ruirui and Wang, Zhongling (2023). Dual-ratiometric magnetic resonance tunable nanoprobe with acidic-microenvironment-responsive property to enhance the visualization of early tumor pathological changes. Nano Research, 16 (7), 10034-10046. doi: 10.1007/s12274-023-5679-x

Star polymer nanomedicines─challenges and future perspectives

Forgham, Helen, Zhu, Jiayuan, Qiao, Ruirui and Davis, Thomas P. (2022). Star polymer nanomedicines─challenges and future perspectives. ACS Applied Polymer Materials, 4 (10), 6784-6796. doi: 10.1021/acsapm.2c01291

Nanomaterials integrated 3D printing for biomedical application

Zhang, Liwen, Forgham, Helen, Shen, Ao, Wang, Jiafan, Zhu, Jiayuan, Huang, Xumin, Tang, Shiyang, Xu, Chun, Davis, Thomas P. and Qiao, Ruirui (2022). Nanomaterials integrated 3D printing for biomedical application. Journal of Materials Chemistry B, 10 (37), 7473-7490. doi: 10.1039/d2tb00931e

Keeping up with the COVID's—Could siRNA‐based antivirals be a part of the answer?

Forgham, Helen, Kakinen, Aleksandr, Qiao, Ruirui and Davis, Thomas P. (2022). Keeping up with the COVID's—Could siRNA‐based antivirals be a part of the answer?. Exploration, 00 (6) 20220012, 20220012. doi: 10.1002/exp.20220012

Aerosol delivery of star polymer-siRNA nanoparticles as a therapeutic strategy to inhibit lung tumor growth

Ma, Z., Wong, S.W., Forgham, H., Esser, L., Lai, M., Leiske, M.N., Kempe, K., Sharbeen, G., Youkhana, J., Mansfeld, F., Quinn, J.F., Phillips, P.A., Davis, T.P., Kavallaris, M. and McCarroll, J.A. (2022). Aerosol delivery of star polymer-siRNA nanoparticles as a therapeutic strategy to inhibit lung tumor growth. Biomaterials, 285 121539, 121539. doi: 10.1016/j.biomaterials.2022.121539

All-in-one inorganic nanoagents for near-infrared-II photothermal-based cancer theranostics

Zhang, L., Forgham, H., Huang, X., Shen, A., Davis, T.P., Qiao, R. and Guo, B. (2022). All-in-one inorganic nanoagents for near-infrared-II photothermal-based cancer theranostics. Materials Today Advances, 14 100226, 100226. doi: 10.1016/j.mtadv.2022.100226

Recent advances in single Fe-based nanoagents for photothermal–chemodynamic cancer therapy

Zhang, Li, Forgham, Helen, Shen, Ao, Qiao, Ruirui and Guo, Bing (2022). Recent advances in single Fe-based nanoagents for photothermal–chemodynamic cancer therapy. Biosensors, 12 (2) 86. doi: 10.3390/bios12020086

Facile synthesis of lactoferrin conjugated ultra small large pore silica nanoparticles for the treatment of glioblastoma

Janjua, Taskeen Iqbal, Ahmed-Cox, Aria, Meka, Anand Kumar, Mansfeld, Friederike M., Forgham, Helen, Ignacio, Rosa Mistica C., Cao, Yuxue, McCarroll, Joshua A., Mazzieri, Roberta, Kavallaris, Maria and Popat, Amirali (2021). Facile synthesis of lactoferrin conjugated ultra small large pore silica nanoparticles for the treatment of glioblastoma. Nanoscale, 13 (40), 16909-16922. doi: 10.1039/d1nr03553c

Effective targeting of NAMPT in patient-derived xenograft models of high-risk pediatric acute lymphoblastic leukemia

Somers, Klaartje, Evans, Kathryn, Cheung, Leanna, Karsa, Mawar, Pritchard, Tara, Kosciolek, Angelika, Bongers, Angelika, El-Ayoubi, Ali, Forgham, Helen, Middlemiss, Shiloh, Mayoh, Chelsea, Jones, Luke, Gupta, Mahima, Kees, Ursula R., Chernova, Olga, Korotchkina, Lioubov, Gudkov, Andrei V., Erickson, Stephen W., Teicher, Beverly, Smith, Malcolm A., Norris, Murray D., Haber, Michelle, Lock, Richard B. and Henderson, Michelle J. (2019). Effective targeting of NAMPT in patient-derived xenograft models of high-risk pediatric acute lymphoblastic leukemia. Leukemia, 34 (6), 1524-1539. doi: 10.1038/s41375-019-0683-6

Identification of novel medulloblastoma cell-targeting peptides for use in selective chemotherapy drug delivery

Tjandra, Kristel C., McCarthy, Nigel, Yang, Lu, Laos, Alistair J., Sharbeen, George, Phillips, Phoebe A., Forgham, Helen, Sagnella, Sharon M., Whan, Renee M., Kavallaris, Maria, Thordarson, Pall and McCarroll, Joshua A. (2019). Identification of novel medulloblastoma cell-targeting peptides for use in selective chemotherapy drug delivery. Journal of Medicinal Chemistry, 63 (5), 2181-2193. doi: 10.1021/acs.jmedchem.9b00851

A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

Somers, Klaartje, Wen, Victoria W., Middlemiss, Shiloh M. C., Osborne, Brenna, Forgham, Helen, Jung, MoonSun, Karsa, Mawar, Clifton, Molly, Bongers, Angelika, Gao, Jixuan, Mayoh, Chelsea, Raoufi-Rad, Newsha, Kusnadi, Eric P., Hannan, Kate M., Scott, David A., Kwek, Alan, Liu, Bing, Flemming, Claudia, Chudakova, Daria A., Pandher, Ruby, Failes, Tim W., Lim, James, Angeli, Andrea, Osterman, Andrei L., Imamura, Toshihiko, Kees, Ursula R., Supuran, Claudiu T., Pearson, Richard B., Hannan, Ross D. ... Henderson, Michelle J. (2019). A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction. Oncogene, 38 (20), 3824-3842. doi: 10.1038/s41388-018-0666-5

Differentiation of human embryonic stem cells to sympathetic neurons: a potential model for understanding neuroblastoma pathogenesis

Carr-Wilkinson, Jane, Prathalingam, Nilendran, Pal, Deepali, Moad, Mohammad, Lee, Natalie, Sundaresh, Aishwarya, Forgham, Helen, James, Peter, Herbert, Mary, Lako, Majlinda and Tweddle, Deborah A (2018). Differentiation of human embryonic stem cells to sympathetic neurons: a potential model for understanding neuroblastoma pathogenesis. Stem Cells International, 2018 4391641, 1-12. doi: 10.1155/2018/4391641

Stem cell markers in neuroblastoma—an emerging role for LGR5

Forgham, Helen, Johnson, Darren, Carter, Noel, Veuger, Stephany and Carr-Wilkinson, Jane (2015). Stem cell markers in neuroblastoma—an emerging role for LGR5. Frontiers in Cell and Developmental Biology, 3 (DEC) 77. doi: 10.3389/fcell.2015.00077

Development and Biological Optimization of Star-Shaped Polymeric Nanoparticles for the Delivery of Therapeutic siRNA to Lung Cancer Cells In Vitro and In Vivo

Ma, Zerong, Esser, Lars, Lai, May, Leiske, Meike N., Forgham, Helen, Wong, Sze W., Mansfeld, Friederike M., Lewis, Craig R., Davis, Thomas P., Quinn, John, Phillips, Phoebe, Kavallaris, Maria and McCarroll, Joshua A. (2020). Development and Biological Optimization of Star-Shaped Polymeric Nanoparticles for the Delivery of Therapeutic siRNA to Lung Cancer Cells In Vitro and In Vivo. 23rd Annual Meeting of the American-Society-for-Gene-and-Cell-Therapy, Electr Network, 12-15 May 2020. Cambridge, MA, United States: Cell Press.