The University of Queensland

Side effects of central analgesic drugs

Imam, M. Z., Kuo, A. and Smith, M. T. (2022). Side effects of central analgesic drugs. Drug discovery and evaluation: safety and pharmacokinetic assays. (pp. 1-24) Cham, Switzerland: Springer International Publishing. doi: 10.1007/978-3-030-73317-9_70-1

J-2156, a small molecule somatostatin type 4 receptor agonist, alleviated hindpaw hypersensitivity in the streptozotocin-induced rat model of painful diabetic neuropathy but with a 2-fold decrease in potency at an advanced stage in the model, mimicking morphine

Kuo, A., Imam, M. Z., Li, R., Lin, L., Raboczyj, A., Bohmer, A. E., Nicholson, J. R., Corradini, L. and Smith, M. T. (2024). J-2156, a small molecule somatostatin type 4 receptor agonist, alleviated hindpaw hypersensitivity in the streptozotocin-induced rat model of painful diabetic neuropathy but with a 2-fold decrease in potency at an advanced stage in the model, mimicking morphine. Frontiers in Pharmacology, 15 1346801. doi: 10.3389/fphar.2024.1346801

In Vitro Assessment of the Metabolic Stability of Two Novel Endomorphin-2 Analogs, CYX-5 and CYX-6, in Rat Liver Microsomes

Imam, Mohammad Zafar, Ghassabian, Sussan, Kuo, Andy, Cai, Yunxin, Qin, Yajuan, Li, Tingyou and Smith, Maree T. (2023). In Vitro Assessment of the Metabolic Stability of Two Novel Endomorphin-2 Analogs, CYX-5 and CYX-6, in Rat Liver Microsomes. European Journal of Drug Metabolism and Pharmacokinetics, 48 (4), 463-466. doi: 10.1007/s13318-023-00828-6

Multitargeted opioid ligand discovery as a strategy to retain analgesia and reduce opioid-related adverse effects

Smith, Maree T., Kong, Dehui, Kuo, Andy, Imam, Mohammad Z. and Williams, Craig M. (2023). Multitargeted opioid ligand discovery as a strategy to retain analgesia and reduce opioid-related adverse effects. Journal of Medicinal Chemistry, 66 (6), 3746-3784. doi: 10.1021/acs.jmedchem.2c01695

CYX-5, a G-protein biassed MOP receptor agonist, DOP receptor antagonist and KOP receptor agonist, evokes constipation but not respiratory depression relative to morphine in rats

Imam, Mohammad Zafar, Kuo, Andy, Ghassabian, Sussan, Cai, Yunxin, Qin, Yajuan, Li, Tingyou and Smith, Maree T. (2023). CYX-5, a G-protein biassed MOP receptor agonist, DOP receptor antagonist and KOP receptor agonist, evokes constipation but not respiratory depression relative to morphine in rats. Pharmacological Reports, 75 (3), 634-646. doi: 10.1007/s43440-023-00446-8

Analgesic opioid ligand discovery based on nonmorphinan scaffolds derived from natural sources

Smith, Maree T., Kong, Dehui, Kuo, Andy, Imam, Mohammad Z. and Williams, Craig M. (2022). Analgesic opioid ligand discovery based on nonmorphinan scaffolds derived from natural sources. Journal of Medicinal Chemistry, 65 (3) acs.jmedchem.0c01915, 1612-1661. doi: 10.1021/acs.jmedchem.0c01915

Assessment of the anti-allodynic efficacy of a glycine transporter 2 inhibitor relative to pregabalin and duloxetine in a rat model of prostate cancer-induced bone pain

Imam, Mohammad Zafar, Kuo, Andy, Nicholson, Janet R., Corradini, Laura and Smith, Maree T. (2020). Assessment of the anti-allodynic efficacy of a glycine transporter 2 inhibitor relative to pregabalin and duloxetine in a rat model of prostate cancer-induced bone pain. Pharmacological Reports, 72 (5), 1418-1425. doi: 10.1007/s43440-020-00145-8

Intracerebroventricular administration of CYX-6, a potent μ-opioid receptor agonist, a δ- and κ-opioid receptor antagonist and a biased ligand at μ, δ & κ-opioid receptors, evokes antinociception with minimal constipation and respiratory depression in rats in contrast to morphine

Imam, Mohammad Zafar, Kuo, Andy, Ghassabian, Sussan, Cai, Yunxin, Qin, Yajuan, Li, Tingyou and Smith, Maree T. (2020). Intracerebroventricular administration of CYX-6, a potent μ-opioid receptor agonist, a δ- and κ-opioid receptor antagonist and a biased ligand at μ, δ & κ-opioid receptors, evokes antinociception with minimal constipation and respiratory depression in rats in contrast to morphine. European Journal of Pharmacology, 871 172918, 172918. doi: 10.1016/j.ejphar.2020.172918

Countering opioid-induced respiratory depression by non-opioids that are respiratory stimulants

Imam, Mohammad Zafar, Kuo, Andy and Smith, Maree T. (2020). Countering opioid-induced respiratory depression by non-opioids that are respiratory stimulants. F1000Research, 9 91, 91. doi: 10.12688/f1000research.21738.1

Trichosanthes dioica Roxb.: a vegetable with diverse pharmacological properties

Khandaker, Mahia, Akter, Saleha and Imam, Mohammad Zafar (2018). Trichosanthes dioica Roxb.: a vegetable with diverse pharmacological properties. Food Science and Human Wellness, 7 (1), 34-48. doi: 10.1016/j.fshw.2017.12.005

Progress in understanding mechanisms of opioid-induced gastrointestinal adverse effects and respiratory depression

Imam, Mohammad Zafar, Kuo, Andy, Ghassabian, Sussan and Smith, Maree T. (2017). Progress in understanding mechanisms of opioid-induced gastrointestinal adverse effects and respiratory depression. Neuropharmacology, 131, 238-255. doi: 10.1016/j.neuropharm.2017.12.032

Antinociceptive activity of methanol extract of leaves of Solanum sisymbriifolium in heat and chemical-induced pain

Nasrin, Tania, Khandaker, Mahia, Akter, Saleha and Imam, Mohammad Zafar (2017). Antinociceptive activity of methanol extract of leaves of Solanum sisymbriifolium in heat and chemical-induced pain. Journal of Applied Pharmaceutical Science, 7 (11), 142-146. doi: 10.7324/JAPS.2017.71121

Antinociceptive and neuropharmacological activities of methanol extract of Phoenix sylvestris fruit pulp

Shajib, Md. Shafiullah, Akter, Saleha, Ahmed, Tajnin and Imam, Mohammad Zafar (2015). Antinociceptive and neuropharmacological activities of methanol extract of Phoenix sylvestris fruit pulp. Frontiers in Pharmacology, 6 (OCT) 212, 212. doi: 10.3389/fphar.2015.00212

Antinociceptive effect of methanol extract of leaves of Persicaria hydropiper in mice

Khatun, Ambia, Imam, Mohammad Zafar and Rana, Md Sohel (2015). Antinociceptive effect of methanol extract of leaves of Persicaria hydropiper in mice. BMC Complementary and Alternative Medicine, 15 (1) 63, 63. doi: 10.1186/s12906-015-0558-y

Evaluation of antinociceptive activity of ethanol extract of leaves of Adenanthera pavonina

Moniruzzaman, Md., Khatun, Ambia and Imam, Mohammad Zafar (2015). Evaluation of antinociceptive activity of ethanol extract of leaves of Adenanthera pavonina. Evidence-Based Complementary and Alternative Medicine, 2015 412497, 1-8. doi: 10.1155/2015/412497

Evaluation of antinociceptive effect of methanolic extract of leaves of Crataeva nurvala Buch.-Ham.

Moniruzzaman, Md and Imam, Mohammad Zafar (2014). Evaluation of antinociceptive effect of methanolic extract of leaves of Crataeva nurvala Buch.-Ham.. BMC Complementary and Alternative Medicine, 14 (1) 354, 1-7. doi: 10.1186/1472-6882-14-354

Antinociceptive effect of ethanol extract of leaves of Lannea coromandelica

Imam, Mohammad Zafar and Moniruzzaman, Md (2014). Antinociceptive effect of ethanol extract of leaves of Lannea coromandelica. Journal of Ethnopharmacology, 154 (1), 109-115. doi: 10.1016/j.jep.2014.03.032

Evaluation of antinociceptive activity of hydromethanol extract of Cyperus rotundus in mice

Imam, Mohammad Zafar and Sumi, Chandra Datta (2014). Evaluation of antinociceptive activity of hydromethanol extract of Cyperus rotundus in mice. BMC Complementary and Alternative Medicine, 14 83. doi: 10.1186/1472-6882-14-83

Awareness regarding the importance of calcium and vitamin D among the undergraduate pharmacy students in Bangladesh

Uddin, Riaz, Huda, Naz Hasan, Jhanker, Yeakuty Marzan, Jesmeen, Tasbira, Imam, Mohammad Zafar and Akter, Saleha (2013). Awareness regarding the importance of calcium and vitamin D among the undergraduate pharmacy students in Bangladesh. BMC Research Notes, 6 (1) 134. doi: 10.1186/1756-0500-6-134

Antinociceptive, antidiarrheal, and neuropharmacological activities of Barringtonia acutangula

Imam, Mohammad Zafar, Sultana, Shamima and Akter, Saleha (2012). Antinociceptive, antidiarrheal, and neuropharmacological activities of Barringtonia acutangula. Pharmaceutical Biology, 50 (9), 1078-1084. doi: 10.3109/13880209.2012.656850

Antinociceptive activity of methanol extract of flowers of Impatiens balsamina

Imam, Mohammad Zafar, Nahar, Nazmun, Akter, Saleha and Rana, Md. Sohel (2012). Antinociceptive activity of methanol extract of flowers of Impatiens balsamina. Journal of Ethnopharmacology, 142 (3), 804-810. doi: 10.1016/j.jep.2012.06.004

Antioxidant activities of different parts of Musa sapientum L. ssp. sylvestris fruit

Imam, Mohammad Zafar, Akter, Saleha, Mazumder, Md. Ehsanul Hoque and Rana, Md. Sohel (2011). Antioxidant activities of different parts of Musa sapientum L. ssp. sylvestris fruit. Journal of Applied Pharmaceutical Science, 1 (10), 68-72.

Antioxidant and antihyperglycemic activities of methanolic extract of Glinus oppositifolius leaves

Hoque, Nazia, Imam, Mohammad Zafar, Akter, Saleha, Ahmed, Jamiuddin, Mazumder, Ehsanul Hoque, Hasan, S.M. Raquibul and Rana, Sohel (2011). Antioxidant and antihyperglycemic activities of methanolic extract of Glinus oppositifolius leaves. Journal of Applied Pharmaceutical Science, 1 (7), 50-53.

Analgesic and anti-inflammatory potential of methanolic extract of glinus oppositifolius L

Hoque, Nazia, Habib, Razibul Md, Imam, Mohammad Zafar, Ahmed, Jamiuddin and Rana, Sohel Md (2011). Analgesic and anti-inflammatory potential of methanolic extract of glinus oppositifolius L. Australian Journal of Basic and Applied Sciences, 5 (8), 729-733.

Musa paradisiaca L. and Musa sapientum L. : A phytochemical and pharmacological review

Imam, Mohammad Zafar and Akter, Saleha (2011). Musa paradisiaca L. and Musa sapientum L. : A phytochemical and pharmacological review. Journal of Applied Pharmaceutical Science, 1 (5), 14-20.

Analgesic efficacy of novel opioid compounds relative to adverse effects in rats

Imam, Mohammad Zafar (2019). Analgesic efficacy of novel opioid compounds relative to adverse effects in rats. PhD Thesis, Faculty of Medicine, The University of Queensland. doi: 10.14264/uql.2019.625