The University of Queensland

Drug targets for biologics

Lai, Felcia, Hawkins, Bryson A., Cruz, Esteban, Hanrahan, Jane R., Groundwater, Paul W. and Hibbs, David E. (2021). Drug targets for biologics. Biologics, biosimilars, and biobetters: an introduction for pharmacists, physicians, and other health practitioners. (pp. 195-212) edited by Iqbal Ramzan. Hoboken, NJ United States: Wiley. doi: 10.1002/9781119564690.ch5

Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cells

Padmanabhan, Pranesh, Kneynsberg, Andrew, Cruz, Esteban, Briner, Adam and Götz, Jürgen (2024). Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cells. Molecular Brain, 17 (1) 7, 7. doi: 10.1186/s13041-024-01078-6

Break and accelerator—The mechanics of Tau (and amyloid) toxicity

Cruz, Esteban, Nisbet, Rebecca M. and Götz, Jürgen (2023). Break and accelerator—The mechanics of Tau (and amyloid) toxicity. Cytoskeleton, 81 (1), 24-29. doi: 10.1002/cm.21781

Opportunities and challenges in delivering biologics for Alzheimer's disease by low-intensity ultrasound

Chen, Liyu, Cruz, Esteban, Oikari, Lotta E., Padmanabhan, Pranesh, Song, Jae and Götz, Jürgen (2022). Opportunities and challenges in delivering biologics for Alzheimer's disease by low-intensity ultrasound. Advanced Drug Delivery Reviews, 189 114517, 1-18. doi: 10.1016/j.addr.2022.114517

Ultrasound-mediated delivery of novel tau-specific monoclonal antibody enhances brain uptake but not therapeutic efficacy

Bajracharya, Rinie, Cruz, Esteban, Götz, Jürgen and Nisbet, Rebecca M. (2022). Ultrasound-mediated delivery of novel tau-specific monoclonal antibody enhances brain uptake but not therapeutic efficacy. Journal of Controlled Release, 349, 634-648. doi: 10.1016/j.jconrel.2022.07.026

Single‐molecule imaging reveals Tau trapping at nanometer‐sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion

Padmanabhan, Pranesh, Kneynsberg, Andrew, Cruz, Esteban, Amor, Rumelo, Sibarita, Jean‐Baptiste and Götz, Jürgen (2022). Single‐molecule imaging reveals Tau trapping at nanometer‐sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion. The EMBO Journal, 41 (19) e111265, 1-16. doi: 10.15252/embj.2022111265

Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model

Chen, Liyu, Sutharsan, Ratneswary, Lee, Jonathan LF, Cruz, Esteban, Asnicar, Blaise, Palliyaguru, Tishila, Wasielewska, Joanna M, Gaudin, Arnaud, Song, Jae, Leinenga, Gerhard and Götz, Jürgen (2022). Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model. Theranostics, 12 (5), 1952-1970. doi: 10.7150/thno.65539

Glycan profile analysis of engineered trastuzumab with rationally added glycosylation sequons presents significantly increased glycan complexity

Cruz, Esteban, Sifniotis, Vicki, Sumer-Bayraktar, Zeynep, Reslan, Mouhamad, Wilkinson-White, Lorna, Cordwell, Stuart and Kayser, Veysel (2021). Glycan profile analysis of engineered trastuzumab with rationally added glycosylation sequons presents significantly increased glycan complexity. Pharmaceutics, 13 (11) 1747. doi: 10.3390/pharmaceutics13111747

Therapeutic ultrasound as a treatment modality for physiological and pathological ageing including Alzheimer’s disease

Götz, Jürgen, Richter-Stretton, Gina and Cruz, Esteban (2021). Therapeutic ultrasound as a treatment modality for physiological and pathological ageing including Alzheimer’s disease. Pharmaceutics, 13 (7) 1002, 1002. doi: 10.3390/pharmaceutics13071002

Enhancing the stability of adalimumab by engineering additional glycosylation motifs

Reslan, Mouhamad, Sifniotis, Vicki, Cruz, Esteban, Sumer-Bayraktar, Zeynep, Cordwell, Stuart and Kayser, Veysel (2020). Enhancing the stability of adalimumab by engineering additional glycosylation motifs. International Journal of Biological Macromolecules, 158, 189-196. doi: 10.1016/j.ijbiomac.2020.04.147

Structural biology workflow for the expression and characterization of functional human sodium glucose transporter type 1 in Pichia pastoris

Suades, Albert, Alcaraz, Antonio, Cruz, Esteban, Álvarez-Marimon, Elena, Whitelegge, Julian P., Manyosa, Joan, Cladera, Josep and Perálvarez-Marín, Alex (2019). Structural biology workflow for the expression and characterization of functional human sodium glucose transporter type 1 in Pichia pastoris. Scientific Reports, 9 (1) 1203. doi: 10.1038/s41598-018-37445-2

Current advancements in addressing key challenges of therapeutic antibody design, manufacture, and formulation

Sifniotis, Vicki, Cruz, Esteban, Eroglu, Barbaros and Kayser, Veysel (2019). Current advancements in addressing key challenges of therapeutic antibody design, manufacture, and formulation. Antibodies, 8 (2) 36, 36. doi: 10.3390/antib8020036

Synthesis and enhanced cellular uptake in vitro of anti-HER2 multifunctional gold nanoparticles

Cruz, Esteban and Kayser, Veysel (2019). Synthesis and enhanced cellular uptake in vitro of anti-HER2 multifunctional gold nanoparticles. Cancers, 11 (6) 870. doi: 10.3390/cancers11060870

Monoclonal antibody therapy of solid tumors: clinical limitations and novel strategies to enhance treatment efficacy

Cruz, Esteban and Kayser, Veysel (2019). Monoclonal antibody therapy of solid tumors: clinical limitations and novel strategies to enhance treatment efficacy. Biologics: Targets and Therapy, 13, 33-51. doi: 10.2147/BTT.S166310

Demonstration of in vitro host-guest complex formation and safety of para-sulfonatocalix[8]arene as a delivery vehicle for two antibiotic drugs

Moussa, Yvonne E., Ong, Yu Qing Elysia, Perry, John D., Cheng, Zhengqi, Kayser, Veysel, Cruz, Esteban, Kim, Ryung Rae, Sciortino, Natasha and Wheate, Nial J. (2018). Demonstration of in vitro host-guest complex formation and safety of para-sulfonatocalix[8]arene as a delivery vehicle for two antibiotic drugs. Journal of Pharmaceutical Sciences, 107 (12), 3105-3111. doi: 10.1016/j.xphs.2018.08.016

Site-specific glycosylation profile of influenza A (H1N1) hemagglutinin through tandem mass spectrometry

Cruz, Esteban, Cain, Joel, Crossett, Ben and Kayser, Veysel (2018). Site-specific glycosylation profile of influenza A (H1N1) hemagglutinin through tandem mass spectrometry. Human Vaccines and Immunotherapeutics, 14 (3), 508-517. doi: 10.1080/21645515.2017.1377871

The state-of-play and future of antibody therapeutics

Elgundi, Zehra, Reslan, Mouhamad, Cruz, Esteban, Sifniotis, Vicki and Kayser, Veysel (2017). The state-of-play and future of antibody therapeutics. Advanced Drug Delivery Reviews, 122, 2-19. doi: 10.1016/j.addr.2016.11.004

Laboratory scale production and purification of a therapeutic antibody

Elgundi, Zehra, Sifniotis, Vicki, Reslan, Mouhamad, Cruz, Esteban and Kayser, Veysel (2017). Laboratory scale production and purification of a therapeutic antibody. Journal of Visualized Experiments, 2017 (119) e55153. doi: 10.3791/55153