Mechanisms of drug-induced liver damage.
Liver disease has long been associated with the abuse and clinical use of drugs. My research interests focus on ethanol, perhaps the most commonly abused drug, and the widely used non-steroidal anti-inflammatory drugs (NSAIDS). Both NSAIDS and ethanol are widely tolerated but induce liver disease in a small number of individuals.
Research projects listed below investigate immunological and genetic phenomena associated with drug-induced liver disease.
Journal Article: Wasabi (Eutrema japonicum) reduces obesity and blood pressure in diet-induced metabolic syndrome in rats
Thomaz, Fernanda Santos, Tan, Yuen P., Williams, Craig M., Ward, Leigh C., Worrall, Simon and Panchal, Sunil K. (2022). Wasabi (Eutrema japonicum) reduces obesity and blood pressure in diet-induced metabolic syndrome in rats. Foods, 11 (21) 3435, 1-12. doi: 10.3390/foods11213435
Journal Article: A systematic review of intravenous β-hydroxybutyrate use in humans – a promising future therapy?
White, Hayden, Heffernan, Aaron J., Worrall, Simon, Grunsfeld, Alexander and Thomas, Matt (2021). A systematic review of intravenous β-hydroxybutyrate use in humans – a promising future therapy?. Frontiers in Medicine, 8 740374, 740374. doi: 10.3389/fmed.2021.740374
Journal Article: The influence of wasabi on the gut microbiota of high-carbohydrate, high-fat diet-induced hypertensive Wistar rats
Thomaz, Fernanda S., Altemani, Faisal, Panchal, Sunil K., Worrall, Simon and Dekker Nitert, Marloes (2020). The influence of wasabi on the gut microbiota of high-carbohydrate, high-fat diet-induced hypertensive Wistar rats. Journal of Human Hypertension, 35 (2), 170-180. doi: 10.1038/s41371-020-0359-8
Choroid Plexus Dysfunction the Pathogenesis of Alcohol Intoxication
(2010)
(2006) Australian Brewers' Foundation
(2001) University of Queensland Small Grants Scheme
The influence of Wasabi (Wasabia japonica) on obesity and metabolic syndrome
(2020) Doctor Philosophy
Analysis of acyl coenzyme A: cholesterol acyltransferase (ACAT) expression in human tissues
(2015) Master Philosophy
CYTOTOXIC EFFECTS OF PYRROLIZIDINE ALKALOIDS
(2004) Doctor Philosophy
Biochemistry for health professionals
Batmanian, Laura, Ridge, Justin and Worrall, Simon (2011). Biochemistry for health professionals. Chatswood, NSW, Australia: Elsevier Australia.
The effect of diet on protein modification by ethanol metabolites
Worrall, Simon (2013). The effect of diet on protein modification by ethanol metabolites. Alcohol, nutrition, and health consequences. (pp. 111-130) edited by Ronald Ross Watson, Victor R. Preedy and Sherma Zibadi. New York, NY, United States: Springer. doi: 10.1007/978-1-62703-047-2_9
Worrall, S. and Thiele, G.M. (2005). Modification of proteins by reactive ethanol metabolites: Adduct structure, functional and pathological consequences. Comprehensive Handbook of Alcohol Related Pathology Vol. 3. (pp. 1209-1222) edited by V.R. Preedy and R.R. Watson. Great Britain: Elsevier. doi: 10.1016/B978-012564370-2/50094-5
Worrall, S. (2004). The effect of diet on protein modification by ethanol metabolites in tissues damaged in chronic alcohol abuse. Nutrition and Alcohol: Linking Nutrient Interactions and Dietary Intake. (pp. 219-248) edited by R. R. Watson and V. R. Preedy. Florida: CRC Press. doi: 10.1201/9780203507636.ch13
Preedy, V. R., Dunn, M. J., Hunter, R., Mantle, D., Worrall, S. and Richardson, P. J. (2002). Alcohol and heart muscle proteins: With special reference to measurement of protein synthesis in vivo. Alcohol and Heart Disease. (pp. 197-211) CRC Press.
Alcohol and the heart in humans and animal models
Dunn, M. J., Patel, V. B., Preedy, V. R., Richardson, P. and Worrall, S. (2001). Alcohol and the heart in humans and animal models. Alcohol and Coffee Use in the Aging. (pp. 41-56) edited by Ronald R Watson. USA: CRC Press LLC. doi: 10.1201/9781420038941.ch3
Pathogenic Mechanisms in Alcoholic Myopathy
Preedy, Victor, Peters, Timothy, Adachi, Junko, Ahmed, Sohail, Mantle, David, Niemela, Onni, Parkkila, Seppo and Worrall, Simon (2001). Pathogenic Mechanisms in Alcoholic Myopathy. Alcohol in Health and Disease. (pp. 243-259) Boca Raton, FL United States: CRC Press. doi: 10.3109/9780203902172
Worrall, S. (2001). Proteins modified by direct and indirect ethanol metabolites, and their associated antibodies, as markers of alcohol intake. New and Upcoming Markers of Alcohol Consumption. (pp. 94-110) edited by FM Wurst. Germany: Springer Verlag.
Thomaz, Fernanda Santos, Tan, Yuen P., Williams, Craig M., Ward, Leigh C., Worrall, Simon and Panchal, Sunil K. (2022). Wasabi (Eutrema japonicum) reduces obesity and blood pressure in diet-induced metabolic syndrome in rats. Foods, 11 (21) 3435, 1-12. doi: 10.3390/foods11213435
A systematic review of intravenous β-hydroxybutyrate use in humans – a promising future therapy?
White, Hayden, Heffernan, Aaron J., Worrall, Simon, Grunsfeld, Alexander and Thomas, Matt (2021). A systematic review of intravenous β-hydroxybutyrate use in humans – a promising future therapy?. Frontiers in Medicine, 8 740374, 740374. doi: 10.3389/fmed.2021.740374
Thomaz, Fernanda S., Altemani, Faisal, Panchal, Sunil K., Worrall, Simon and Dekker Nitert, Marloes (2020). The influence of wasabi on the gut microbiota of high-carbohydrate, high-fat diet-induced hypertensive Wistar rats. Journal of Human Hypertension, 35 (2), 170-180. doi: 10.1038/s41371-020-0359-8
Wasabi supplementation alters the composition of the gut microbiota of diet-induced obese rats
Thomaz, Fernanda S., Tomsett, Kate I., Panchal, Sunil K., Worrall, Simon and Dekker Nitert, Marloes (2020). Wasabi supplementation alters the composition of the gut microbiota of diet-induced obese rats. Journal of Functional Foods, 67 103868, 103868. doi: 10.1016/j.jff.2020.103868
Development of DNA aptamers targeting low-molecular-weight amyloid-β peptide aggregates in vitro
Chakravarthy, Madhuri, AlShamaileh, Hadi, Huang, He, Tannenberg, Rudi K., Chen, Suxiang, Worrall, Simon, Dodd, Peter R. and Veedu, Rakesh N. (2018). Development of DNA aptamers targeting low-molecular-weight amyloid-β peptide aggregates in vitro. Chemical Communications, 54 (36), 4593-4596. doi: 10.1039/c8cc02256a
Toselli, Francesca, Depaz, Iris M. Booth, Worrall, Simon, Etheridge, Naomi, Dodd, Peter R., Wilce, Peter A. and Gillam, Elizabeth M. J. (2015). Expression of CYP2E1 and CYP2U1 proteins in amygdala and prefrontal cortex: influence of alcoholism and smoking. Alcoholism: Clinical and Experimental Research, 39 (5), 790-797. doi: 10.1111/acer.12697
White, Hayden, Venkatesh, Balasubramanian, Jones, Mark, Worrall, Simon, Chuah, Teong and Ordonez, Jenny (2013). Effect of a hypertonic balanced ketone solution on plasma, CSF and brain beta-hydroxybutyrate levels and acid-base status. Intensive Care Medicine, 39 (4), 727-733. doi: 10.1007/s00134-012-2790-y
Partadiredja, G., Worrall, S. and Bedi, K. S. (2009). Early life undernutrition alters the level of reduced glutathione but not the activity levels of reactive oxygen species enzymes or lipid peroxidation in the mouse forebrain. Brain Research, 1285, 22-29. doi: 10.1016/j.brainres.2009.06.010
Partadiredja, G., Worrall, S., Simpson, R. and Bedi, K. S. (2008). Pre-weaning undernutrition alters the expression levels of reactive oxygen species enzymes but not their activity levels or lipid peroxidation in the rat brain. Brain Research, 1222, 69-78. doi: 10.1016/j.brainres.2008.05.046
Protein adduct species in muscle and liver of rats following acute ethanol administration
Patel, Vinood B., Worrall, Simon, Emery, Peter W. and Preedy, Victor R. (2005). Protein adduct species in muscle and liver of rats following acute ethanol administration. Alcohol and Alcoholism, 40 (6), 485-493. doi: 10.1093/alcalc/agh196
Generation of aldehyde-derived protein modifications in ethanol-exposed heart
Niemela, O., Parkkila, S., Worrall, S., Emery, P. W. and Preedy, V. R. (2003). Generation of aldehyde-derived protein modifications in ethanol-exposed heart. Alcoholism-clinical And Experimental Research, 27 (12), 1987-1992. doi: 10.1097/01.ALC.0000099260.58926.F2
Free radicals in alcoholic myopathy: Indices of damage and preventive studies
Preedy, Victor R., Adachi, Junko, Asano, Migiwa, Koll, Michael, Mantle, David, Niemela, Onni, Parkkila, Seppo, Paice, Alistair G., Peters, Timothy, Rajendram, Rajkumar, Seitz, Helmut, Ueno, Yasuhiro and Worrall, Simon (2002). Free radicals in alcoholic myopathy: Indices of damage and preventive studies. Free Radical Biology And Medicine, 32 (8), 683-687. doi: 10.1016/S0891-5849(01)00794-8
The Mallory body as an aggresome: In vitro studies
Riley, N. E., Li, J., Worrall, S., Rothnagel, J. A., Swagell, C., van Leeuwen, F. W. and French, S. W. (2002). The Mallory body as an aggresome: In vitro studies. Experimental and Molecular Pathology, 72 (1), 17-23. doi: 10.1006/exmp.2001.2413
Worrall, S., Niemela, O., Parkkila, S., Peters, T. J. and Preedy, V. R. (2001). Protein adducts in type I and type II fibre predominant muscles of the ethanol-fed rat: preferential localisation in the sarcolemmal and subsarcolemmal region. European Journal of Clinical Investigation, 31 (8), 723-730. doi: 10.1046/j.1365-2362.2001.00848.x
Elucidation of reaction scheme describing malondialdehyde-acetaldehyde-protein adduct formation
Tuma, Dean J., Kearley, Mark L., Thiele, Geoffrey M., Worrall, Simon, Haver, Alvin, Klassen, Lynell W. and Sorrell, Michael F. (2001). Elucidation of reaction scheme describing malondialdehyde-acetaldehyde-protein adduct formation. Chemical Research In Toxicology, 14 (7), 822-832. doi: 10.1021/tx000222a
Recent advances in the pathology of alcoholic myopathy
Preedy, Victor R., Adachi, Junko, Peters, Timothy J., Worrall, Simon, Parkkila, Seppo, Niemela, Onni, Asamo, Migiwa, Ueno, Yasuhino, Takeda, Kunihiko, Yamauchi, Masayoshi, Sakamoto, Kazuhiko, Takagi, Masaru, Nakajima, Hisato and Toda, Gotaro (2001). Recent advances in the pathology of alcoholic myopathy. Alcoholism-clinical And Experimental Research, 25 (Supp 1), 54S-59S. doi: 10.1111/j.1530-0277.2001.tb02374.x
The chemistry and biological effects of malondialdehyde-acetaldehyde adducts
Thiele, Geoffrey M., Worrall, Simon, Tuma, Dean J., Klassen, Lynell W., Wyatt, Todd A. and Nagata, Naruhiko (2001). The chemistry and biological effects of malondialdehyde-acetaldehyde adducts. Alcoholism-clinical And Experimental Research, 25 (Supp 1), 218S-224S. doi: 10.1111/j.1530-0277.2001.tb02399.x
Protein modification in ethanol toxicity
Worrall, S. and Thiele, G.M. (2001). Protein modification in ethanol toxicity. Adverse Drug Reactions and Toxicological Reviews, 20 (3), 133-159.
Worrall, Simon, Richardson, Peter J. and Preedy, Victor R. (2000). Experimental heart muscle damage in alcohol feeding is associated with increased amounts of reduced-and unreduced-acetaldehyde and malondialdehyde-acetaldehyde protein adducts. Addiction Biology, 5 (4), 421-427. doi: 10.1111/j.1369-1600.2000.tb00211.x
Worrall, S, de Jersey, J and Wilce, PA (2000). Comparison of the formation of proteins modified by direct and indirect ethanol metabolites in the liver and blood of rats fed the lieber-decarli liquid diet. Alcoholism and Alcoholism, 35 (2), 164-170. doi: 10.1093/alcalc/35.2.164
Tumor necrosis factor-a at presentation in 60 cases of spontaneous canine acute pancreatitis
Ruaux, C., Pennington, H., Worrall, S. and Atwell, R. B. (1999). Tumor necrosis factor-a at presentation in 60 cases of spontaneous canine acute pancreatitis. Veterinary Immunology and Immunopathology, 72 (3-4), 369-376. doi: 10.1016/S0165-2427(99)00108-7
Shahin, M, Moore, MR, Worrall, S, Smith, BL, Seawright, AA and Prakash, AS (1998). H-ras activation is an early event in the ptaquiloside-induced carcinogenesis: Comparison of acute and chronic toxicity in rats (vol 250, pg 491, 1998). Biochemical and Biophysical Research Communications, 251 (2), 668-668. doi: 10.1006/bbrc.1998.9424
Bailey, MJ, Worrall, S, de Jersey, J and Dickinson, RG (1998). Zomepirac acyl glucuronide covalently modifies tubulin in vitro and in vivo and inhibits its assembly in an in vitro system. Chemico-Biological Interactions, 115 (2), 153-166. doi: 10.1016/S0009-2797(98)00071-4
Shahin, Mahmood, Smith, Barry L., Worral, Simon, Moore, Michael R., Seawright, Alan A. and Prakash, Arungundrum S. (1998). Bracken fern carcinogenesis: Multiple intravenous doses of activated ptaquiloside induce DNA adducts, monocytosis, increased TNF alpha levels, and mammary gland carcinoma in rats. Biochemical And Biophysical Research Communications, 244 (1), 192-197. doi: 10.1006/bbrc.1998.8240
A comparison of lipopolysaccharide-induced hepatitis in ethanol-fed Wistar and Lewis rats
Pennington, H.L., Wilce, P.A. and Worrall, S. (1998). A comparison of lipopolysaccharide-induced hepatitis in ethanol-fed Wistar and Lewis rats. Alcoholism: Clinical and Experimental Research, 22 (7), 1525-1530. doi: 10.1097/00000374-199810000-00023
Pennington, H.L., Wilce, P.A. and Worrall, S. (1998). Chemokine and cell adhesion molecule mRNA expression and neutrophil infiltration in lipopolysaccharide-induced hepatitis in ethanol-fed rats. Alcoholism-clinical And Experimental Research, 22 (8), 1713-1718. doi: 10.1097/00000374-199811000-00014
Worrall, S, de Jersey, J, Wilce, PA, Seppa, K, Hurme, L and Sillanaukee, P (1998). Comparison of carbohydrate-deficient transferrin, immunoglobulin A antibodies reactive with acetaldehyde-modified protein and acetaldehyde-modified albumin with conventional markers of alcohol consumption. Alcoholism-clinical And Experimental Research, 22 (9), 1921-1926. doi: 10.1111/j.1530-0277.1998.tb05899.x
Shahin, M., Moore, M. R., Worrall, S., Smith, B. L., Seawright, A. A. and Prakash, A. S. (1998). H-ras activation is an early event in the ptaquiloside-induced carcinogenesis: Comparison of acute and chronic toxicity in rats. Biochemical And Biophysical Research Communications, 250 (2), 491-497. doi: 10.1006/bbrc.1998.9341
Ethanol feeding enhances inflammatory cytokine expression in lipopolysaccharide-induced hepatitis
Pennington, H.L., Hall, P.D., Wilce, P.A. and Worrall, S. (1997). Ethanol feeding enhances inflammatory cytokine expression in lipopolysaccharide-induced hepatitis. Journal of Gastroenterology And Hepatology, 12 (4), 305-313. doi: 10.1111/j.1440-1746.1997.tb00426.x
Worrall, S, deJersey, J, Wilce, PA, Seppa, K, Hurme, L and Sillanaukee, P (1996). Relationship between alcohol intake and immunoglobulin A immunoreactivity with acetaldehyde-modified bovine serum albumin. Alcoholism-Clinical and Experimental Research, 20 (5), 836-840. doi: 10.1111/j.1530-0277.1996.tb05260.x
Fowles, LF, Beck, E, Worrall, S, Shanley, BC and deJersey, J (1996). The formation and stability of imidazolidinone adducts from acetaldehyde and model peptides - A kinetic study with implications for protein modification in alcohol abuse. Biochemical Pharmacology, 51 (10), 1259-1267. doi: 10.1016/0006-2952(95)02408-5
Rat Serum-Albumin Modified by Diflunisal Acyl Glucuronide Is Immunogenic in Rats
Worrall, S and Dickinson, RG (1995). Rat Serum-Albumin Modified by Diflunisal Acyl Glucuronide Is Immunogenic in Rats. Life Sciences, 56 (22), 1921-1930. doi: 10.1016/0024-3205(95)00167-5
Williams, AM, Worrall, S, Dejersey, J and Dickinson, RG (1995). Studies On the Reactivity of Acyl Glucuronides .8. Generation of An Antiserum for the Detection of Diflunisal-Modified Proteins in Diflunisal-Dosed Rats. Biochemical Pharmacology, 49 (2), 209-217. doi: 10.1016/S0006-2952(94)00408-0
Distribution and Turnover of Acetaldehyde-Modified Proteins in Liver and Blood of Ethanol-Fed Rats
Nicholls, RM, Fowles, LF, Worrall, S, Dejersey, J and Wilce, PA (1994). Distribution and Turnover of Acetaldehyde-Modified Proteins in Liver and Blood of Ethanol-Fed Rats. Alcohol and Alcoholism, 29 (2), 149-157. doi: 10.1093/oxfordjournals.alcalc.a045501
Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1994). Anti-Acetaldehyde Adduct Antibodies Generated by Ethanol-Fed Rats React with Reduced and Unreduced Acetaldehyde-Modified Proteins. Alcohol and Alcoholism, 29 (1), 43-50. doi: 10.1093/oxfordjournals.alcalc.a045483
Worrall S., Jersey J.D., Wilce P.A., Seppa K. and Sillanaukee P. (1994). Studies on the usefulness of acetaldehyde-modified proteins and associated antibodies as markers of alcohol abuse.. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement., 2, 503-507.
The effect of chronic ethanol feeding on cytokines in a rat model of alcoholic liver disease.
Worrall S. and Wilce P.A. (1994). The effect of chronic ethanol feeding on cytokines in a rat model of alcoholic liver disease.. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement., 2, 447-451.
Worrall, S, Dejersey, J and Wilce, PA (1993). Antibodies From Alcoholics, Ethanol-Fed Rats and a Rabbit Immunized with Proteins Modified by Acetaldehyde In-Vitro React with Liver Cytosolic Proteins From Ethanol-Fed Rats. Alcohol and Alcoholism, 28 (5), 513-519.
Acetaldehyde-Protein Interactions - Are They Involved in the Pathogenesis of Alcoholic Liver-Disease
Worrall, S, Dejersey, J, Nicholls, R and Wilce, P (1993). Acetaldehyde-Protein Interactions - Are They Involved in the Pathogenesis of Alcoholic Liver-Disease. Digestive Diseases, 11 (4-5), 265-277. doi: 10.1159/000171418
Nicholls, R, Dejersey, J, Worrall, S and Wilce, P (1992). Modification of Proteins and Other Biological Molecules by Acetaldehyde - Adduct Structure and Functional-Significance. International Journal of Biochemistry, 24 (12), 1899-1906. doi: 10.1016/0020-711X(92)90285-9
Williams, AM, Worrall, S, Dejersey, J and Dickinson, RG (1992). Studies On the Reactivity of Acyl Glucuronides .3. Glucuronide-Derived Adducts of Valproic Acid and Plasma-Protein and Anti-Adduct Antibodies in Humans. Biochemical Pharmacology, 43 (4), 745-755. doi: 10.1016/0006-2952(92)90239-F
Acetaldehyde-modified proteins and associated antibodies in ethanol-fed rats
Worrall, S., De Jersey, J., Shanley, B. C. and Wilce, P. A. (1991). Acetaldehyde-modified proteins and associated antibodies in ethanol-fed rats. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, 1, 255-260.
Alcohol abusers exhibit a higher IgA response to acetaldehyde-modified proteins
Worrall, S., De Jersey, J., Shanley, B. C. and Wilce, P. A. (1991). Alcohol abusers exhibit a higher IgA response to acetaldehyde-modified proteins. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, 1, 261-264.
Antibodies Against Acetaldehyde-Modified Epitopes - An Elevated Iga Response in Alcoholics
Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1991). Antibodies Against Acetaldehyde-Modified Epitopes - An Elevated Iga Response in Alcoholics. European Journal of Clinical Investigation, 21 (1), 90-95. doi: 10.1111/j.1365-2362.1991.tb01364.x
Detection of Stable Acetaldehyde-Modified Proteins in the Livers of Ethanol-Fed Rats
Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1991). Detection of Stable Acetaldehyde-Modified Proteins in the Livers of Ethanol-Fed Rats. Alcohol and Alcoholism, 26 (4), 437-444. doi: 10.1093/oxfordjournals.alcalc.a045136
Worrall, S., De Jersey, J., Shanley, B. C. and Wilce, P. A. (1990). Antibodies against acetaldehyde-modified epitopes: Presence in alcoholic, non-alcoholic liver disease and control subjects. Alcohol and Alcoholism, 25 (5), 509-517. doi: 10.1093/oxfordjournals.alcalc.a045044
Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1990). Antibodies Against Acetaldehyde-Modified Epitopes - Presence in Alcoholic, Nonalcoholic Liver-Disease and Control Subjects. Alcohol and Alcoholism, 25 (5), 509-517.
Ethanol Induces the Production of Antibodies to Acetaldehyde-Modified Epitopes in Rats
Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1989). Ethanol Induces the Production of Antibodies to Acetaldehyde-Modified Epitopes in Rats. Alcohol and Alcoholism, 24 (3), 217-223. doi: 10.1093/oxfordjournals.alcalc.a044898
Purification of Brain D2 Dopamine Receptor
Williamson, RA, Worrall, S, Chazot, PL and Strange, PG (1988). Purification of Brain D2 Dopamine Receptor. Embo Journal, 7 (13), 4129-4133. doi: 10.1002/j.1460-2075.1988.tb03307.x
Partial-Purification of the D-2 Dopamine Receptor From Bovine Caudate-Nucleus
Williamson, RA, Worrall, S, Chazot, PL and Strange, PG (1988). Partial-Purification of the D-2 Dopamine Receptor From Bovine Caudate-Nucleus. Biochemical Society Transactions, 16 (4), 450-452. doi: 10.1042/bst0160450
Isolation and Characterization of D2-Dopamine Receptors
Strange, PG, Abbott, WM, Juszczak, R and Worrall, S (1985). Isolation and Characterization of D2-Dopamine Receptors. Biochemical Society Transactions, 13 (6), 1099-1100. doi: 10.1042/bst0131099
Alcohol, in vivo, changes CSF chemistry to increase neuroactive amino acids
Worrall, S., Simmons, G., Mills, P., Rainger, J., Keates, H., Plan, M. and Nixon, P. F. (2018). Alcohol, in vivo, changes CSF chemistry to increase neuroactive amino acids. 19th World Congress of International-Society-for-Biomedical-Research-on-Alcoholism (ISBRA), Kyoto Japan, 9-13 September 2018. Hoboken, NJ United States: Wiley-Blackwell.
Toselli, Francesca, Worrall, Simon, Wilce, Peter A., Dodd, Peter R. and Gillam, Elizabeth M. J. (2014). Cyp2E1 and Cyp2U1 Protein Expression in Human Amygdala and Prefrontal Cortex: Influence of Alcoholism and Smoking. 10th International Meeting of the International Society for the Study of Xenobiotics (ISSX), Toronto, Canada, 29 September - 03 October 2013. New York, NY United States: Informa Healthcare.
Heim, M., Worrall, S. and Wurst, F. (2014). Urinary ethyl glucuronide and blood phosphatidylethanol values in patients undergoing liver biopsy: (i) relationship with alcohol consumption. 37th Annual Scientific Meeting of the Research Society on Alcoholism (RSA) and 17th Congress of the International Society for Biomedical Research on Alcoholism (ISBRA), Bellevue, WA, USA, 21-25 June, 2014. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1111/acer.12451
Heim, M., Worrall, S. and Wurst, F. (2014). Urinary ethyl glucuronide and blood phosphatidylethanol values in patients undergoing liver biopsy: (ii) effect on liver disease. 37th Annual Scientific Meeting of the Research Society on Alcoholism (RSA) and 17th Congress of the International Society for Biomedical Research on Alcoholism (ISBRA), Bellevue, WA, USA, 21-25 June, 2014. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1111/acer.12451
Richards, S., Perry, A., Dodd, P. R. and Worrall, S. (2012). Increased protein carbonyl content and elevated adduct formation in alcoholic cerebellar degeneration. 16th World Congress of the International-Society for Biomedical Research on Alcoholism (ISBRA), Sapporo, Japan, 9-12 September 2012. Hoboken, NJ, United States: Wiley-Blackwell. doi: 10.1111/j.1530-0277.2012.01917.x
Preedy, Victor R., Peter Eriksson, C. J., Morris, John B., Salaspuro, Mikko, Emery, Peter, Thornalley, Paul J., Seitz, Helmut K., Rao, Radhakrishna K., Worrall, Simon, Apte, Minoti V., Okamura, Tomonori and Yin, Shih-Jiun (2007). Discussion.
Quertemont, Etienne, Jamal, Mostofa, Peter Eriksson, C. J., Preedy, Victor R., Worrall, Simon, Deitrich, Richard A., Yin, Shih-Jiun and Apte, Minoti V. (2007). Discussion.
Worrall, Simon, Eriksson, C. J. Peter, Preedy, Victor R., Seitz, Helmut K., Salaspuro, Ville, Salaspuro, Mikko, Apte, Minoti V., Rao, Radhakrishna K., Morris, John B., Thornalley, Paul J. and Ren, Jun (2007). Discussion.
Deitrich, Richard A., Crabb, David W., Salaspuro, Mikko, Peter Eriksson, C. J., Apte, Minoti V., Emery, Peter, Niemelä, Onni, Worrall, Simon, Thornalley, Paul J., Albano, Emanuele, Seitz, Helmut K. and Shukla, Shivendra D. (2007). Discussion.
Seitz, Helmut K., Deitrich, Richard A., Peter Eriksson, C. J., Apte, Minoti V., Preedy, Victor R., Morris, John B., Albano, Emanuele, Worrall, Simon, Emery, Peter, Ren, Jun, Crabb, David W., Salaspuro, Mikko, Quertemont, Etienne, Thornalley, Paul J., Rao, Radhakrishna K., Aranda, Agustin, Okamura, Tomonori, Shukla, Shivendra D., Niemelä, Onni and Jamal, Mostofa (2007). Discussion.
Crabb, David W., Seitz, Helmut K., Emery, Peter, Worrall, Simon, Thornalley, Paul J., Rao, Radhakrishna K., Shukla, Shivendra D., Apte, Minoti V., Deitrich, Richard A., Salaspuro, Mikko, Yin, Shih-Jiun, Ren, Jun, Okamura, Tomonori, Eriksson, C. J. Peter, Preedy, Victor R. and Albano, Emanuele (2007). Discussion.
Thornalley, Paul J., Worrall, Simon, Niemelä, Onni, Rao, Radhakrishna K., Preedy, Victor R., Apte, Minoti V., Albano, Emanuele and Seitz, Helmut K. (2007). Discussion.
Eriksson, C. J. Peter, Preedy, Victor R., Albano, Emanuele, Salaspuro, Mikko, Seitz, Helmut K., Emery, Peter, Apte, Minoti V., Shukla, Shivendra D., Worrall, Simon, Thornalley, Paul J., Rao, Radhakrishna K., Niemelä, Onni, Crabb, David W. and Ren, Jun (2007). Discussion.
Worrall, Simon (2007). General discussion. Symposium on Acetaldehyde-related pathology: Bridging the Trans-disciplinary Divide, London, UK, 5-7 September 2006. Chichester, UK: John Wiley.
Cellular and molecular changes in rat models of alcoholic cardiomyopathy
Preedy, Victor R., Hashimoto, Kijiro, Hirano, Makoto, Hunter, Ross, Nakahara, Tatsuo, Niemela, Onni, Parkkila, Seppo and Worrall, Simon (2006). Cellular and molecular changes in rat models of alcoholic cardiomyopathy. World Congress on Alcohol Research, Sydney, Australia, 10-13 Septmeber 2006. Hoboken, NJ, United States: Wiley-Blackwell Publishing, Inc.. doi: 10.1111/j.1530-0277.2006.00197.x
Detection of elevated protein modification in alcoholic cerebellar degeneration
Perry, Anthony, Dodd, Peter and Worrall, Simon (2006). Detection of elevated protein modification in alcoholic cerebellar degeneration. 29th Annual Meeting of Research Society on Alcoholism, Sydney, Australia, 10-13 September, 2006. Maryland, USA: Blackwell. doi: 10.1111/j.1530-0277.2006.00197.x
Detection of elevated protein modification in human cerebellum in alcoholic cerebellar degeneration
Perry, Anthony, Dodd, Peter R. and Worrall, Simon (2006). Detection of elevated protein modification in human cerebellum in alcoholic cerebellar degeneration. 29th Annual Meeting of the Research Society on Alcoholism ( RSA 2006), Baltimore, MD, USA, 23rd- 29th June, 2006. Maryland: John Wiley & Sons, Inc. doi: 10.1111/j.1530-0277.2006.00150.x
Hepatic adduct levels do not predict the levels of extrahepatic modification
Worrall, Simon (2006). Hepatic adduct levels do not predict the levels of extrahepatic modification. World Congress on Alcohol Research (ISBRA 2006), Sydney, Australia, 10 - 13 September 2006. Oxford: Blackwell Publishing. doi: 10.1111/j.1530-0277.2006.00197.x
Recent advances in alcohol-induced adduct formation
Freeman, Thomas L., Tuma, Dean J., Thiele, Geoffrey M., Klassen, Lynell W., Worrall, Simon, Niemela, Onni, Parkkila, Seppo, Emery, Peter W. and Preedy, Victor R. (2005). Recent advances in alcohol-induced adduct formation. 12th International Congress of the International Society for Biomedical Research on Alcoholism, Heidelberg, Germany, 29 September-2 October 2004. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1097/01.ALC.0000171484.52201.52
Adduct chemistry and mechanisms of adduct formation.
Freeman, TL, Klassen, LW, Worrall, S, Sorrell, MF, Tuma, DJ and Thiele, GM (2004). Adduct chemistry and mechanisms of adduct formation.. 12th International Congress of the International-Society-for-Biomedical-Research-on-Alcoholism, Heidelberg Germany, Sep 29-Oct 02, 2004. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. doi: 10.1097/00000374-200408002-00363
Adduct formation in the liver.
Worrall, S (2004). Adduct formation in the liver.. 12th International Congress of the International-Society-for-Biomedical-Research-on-Alcoholism, Heidelberg Germany, Sep 29-Oct 02, 2004. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. doi: 10.1097/00000374-200408002-00365
Alcoholic skeletal muscle myopathy: A role for protein adducts?
Preedy, VR, Emery, P, Niemela, O, Parkkila, S, Peters, TJ and Worrall, S (2004). Alcoholic skeletal muscle myopathy: A role for protein adducts?. 12th International Congress of the International-Society-for-Biomedical-Research-on-Alcoholism, Heidelberg Germany, Sep 29-Oct 02, 2004. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. doi: 10.1097/00000374-200408002-00367
Liver adduct formation does not predict adduct levels in extrahepatic tissues.
Worrall, S (2004). Liver adduct formation does not predict adduct levels in extrahepatic tissues.. 12th International Congress of the International-Society-for-Biomedical-Research-on-Alcoholism, Heidelberg Germany, Sep 29-Oct 02, 2004. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. doi: 10.1097/00000374-200408002-00010
Pathogenic mechanisms in alcoholic myopathy
Preedy, VR, Peters, TJ, Adachi, J, Ahmed, S, Mantle, D, Niemela, O, Parkkila, S and Worrall, S (2001). Pathogenic mechanisms in alcoholic myopathy. International Titisee Symposium on Health Effects of Alcohol Intake, Titisee Germany, Dec 09-12, 1999. NEW YORK: MARCEL DEKKER.
Worrall, S (2001). Proteins modified by direct and indirect ethanol metabolites, and their associated antibodies, as markers of alcohol intake. 11th World Congress of Psychiatry, Hamburg Germany, Aug 06-11, 1999. BERLIN 33: STEINKOPFF DARMSTADT.
Protein adducts in type I and type II fibre-predominant muscles of the ethanol-fed rat
Niemlea, O., Parkkila, S. and Worrall, S. (2000). Protein adducts in type I and type II fibre-predominant muscles of the ethanol-fed rat. 10th Congress of the International Society for Biomedical Research on Alcoholism, Yokohama, Japan, 2-8 July, 2000.
Studies on protein modification by ethanol metabolites in alcohol abuse
Worrall, S. (2000). Studies on protein modification by ethanol metabolites in alcohol abuse. Joint Meeting of ASCEPT and the British Pharmacological Society, Monash University, Melbourne, 3-6 December 2000. Melbourne, Vic: Australasian Society of Clinical and Experimental Pharmacologists & Toxicologists.
The effect of keratin mutants on hepatocytes metabolising ethanol in culture
Swagell, C. D., Rothnagel, J. A. and Worrall, S. (2000). The effect of keratin mutants on hepatocytes metabolising ethanol in culture. 10th Congress of the International Society for Biomedical Research on Alcoholism: ISBRA 2000, Yokohama, Japan, 2-8 July 2000.
The formation and clearance of MAA adducts in ethanol-fed rats
Worrall, Simon (2000). The formation and clearance of MAA adducts in ethanol-fed rats. 10th Congress of the International Society for Biomedical Reseach on Alcoholism, Yokohama, Japan, 2-8 July, 2000. doi: 10.1111/(ISSN)1530-0277
Acetaldehyde-Modified Proteins and Associated Antibodies in Ethanol-Fed Rats
Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1991). Acetaldehyde-Modified Proteins and Associated Antibodies in Ethanol-Fed Rats. 5th Congress of the International Soc for Biomedical Research On Alcoholism / 1990 Annual Meeting of the Research On Alcoholism, Toronto Canada, Jun 17-22, 1990. OXFORD: OXFORD UNIV PRESS UNITED KINGDOM.
Alcohol Abusers Exhibit a Higher Iga Response to Acetaldehyde-Modified Proteins
Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1991). Alcohol Abusers Exhibit a Higher Iga Response to Acetaldehyde-Modified Proteins. 5th Congress of the International Soc for Biomedical Research On Alcoholism / 1990 Annual Meeting of the Research On Alcoholism, Toronto Canada, Jun 17-22, 1990. OXFORD: OXFORD UNIV PRESS UNITED KINGDOM.
Detection of Acetaldehyde-Modified Proteins in the Livers of Ethanol-Fed Rats
Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1990). Detection of Acetaldehyde-Modified Proteins in the Livers of Ethanol-Fed Rats. LONDON: PORTLAND PRESS. doi: 10.1042/bst0180678
Partial-Purification of D2 Dopamine-Receptors From Bovine Brain
Williamson, RA, Worrall, S and Strange, PG (1987). Partial-Purification of D2 Dopamine-Receptors From Bovine Brain. LONDON: WALTER DE GRUYTER & CO. doi: 10.1042/bst0151155
Purification of D2-Dopamine Receptors From Bovine Brain
Worrall, S, Williamson, RA and Strange, PG (1986). Purification of D2-Dopamine Receptors From Bovine Brain. LONDON: PORTLAND PRESS. doi: 10.1042/bst0141138
Partial-Purification of D2-Dopamine Receptors From Bovine Brain
Worrall, S, Williamson, R and Strange, PG (1986). Partial-Purification of D2-Dopamine Receptors From Bovine Brain. BERLIN: PORTLAND PRESS.
Choroid Plexus Dysfunction the Pathogenesis of Alcohol Intoxication
(2010)
(2006) Australian Brewers' Foundation
(2001) University of Queensland Small Grants Scheme
Oxidative stress in the human alcoholic brain
(1999) Australian Brewers' Foundation
Identification and Characterisation of Adducts from Ethanol Metabolites and Model Peptides
(1998) ARC Australian Research Council (Small grants)
(1997) University of Queensland New Staff Research Grant
Does ethanol alter gene expression to promote alcoholic liver disease
(1996) Mayne Bequest Fund
The influence of Wasabi (Wasabia japonica) on obesity and metabolic syndrome
(2020) Doctor Philosophy — Principal Advisor
Analysis of acyl coenzyme A: cholesterol acyltransferase (ACAT) expression in human tissues
(2015) Master Philosophy — Principal Advisor
CYTOTOXIC EFFECTS OF PYRROLIZIDINE ALKALOIDS
(2004) Doctor Philosophy — Principal Advisor
Characterisation of the expression of indole-metabolising cytochrome P450 enzymes in the human brain
(2013) Doctor Philosophy — Associate Advisor
Other advisors:
(2008) Doctor Philosophy — Associate Advisor
Other advisors:
THE INITIATION OF AUTO-IMMUNE REACTIONS ON ANTI-CONVULSANT INDUCED HYPERSENSITIVITY: THE ROLE OF CYTOCHROME P450 ENZYMES
(2004) Doctor Philosophy — Associate Advisor
Other advisors: