Dr Simon Worrall

Senior Lecturer

School of Chemistry and Molecular Biosciences
Faculty of Science
s.worrall@uq.edu.au
+61 7 336 54626

Overview

Mechanisms of drug-induced liver damage.

Liver disease has long been associated with the abuse and clinical use of drugs. My research interests focus on ethanol, perhaps the most commonly abused drug, and the widely used non-steroidal anti-inflammatory drugs (NSAIDS). Both NSAIDS and ethanol are widely tolerated but induce liver disease in a small number of individuals.

Research projects listed below investigate immunological and genetic phenomena associated with drug-induced liver disease.

  • Does ethanol alter hepatic gene expression to cause liver damage?
  • Does ethanol alter hepatocyte sensitivity to cytokines leading to cell death?
  • Is protein modification by ethanol metabolites involved in the aetiology of alcoholic liver disease?
  • Do keratin 8 or 18 mutants sensitise the liver to toxins?
  • Is an aberrant immune response involved in NSAID adverse reactions?
  • What is the mechanism of toxicity of the Bracken fern toxin ptaquiloside?

Qualifications

  • Doctor of Philosophy, University of Nottingham
  • Bachelor (Honours) of Science (Advanced), University of St Andrews

Publications

View all Publications

Supervision

View all Supervision

Publications

Book

Book Chapter

Journal Article

Conference Publication

  • Worrall, S., Simmons, G., Mills, P., Rainger, J., Keates, H., Plan, M. and Nixon, P. F. (2018). Alcohol, in vivo, changes CSF chemistry to increase neuroactive amino acids. 19th World Congress of International-Society-for-Biomedical-Research-on-Alcoholism (ISBRA), Kyoto Japan, 9-13 September 2018. Hoboken, NJ United States: Wiley-Blackwell.

  • Toselli, Francesca, Worrall, Simon, Wilce, Peter A., Dodd, Peter R. and Gillam, Elizabeth M. J. (2014). Cyp2E1 and Cyp2U1 Protein Expression in Human Amygdala and Prefrontal Cortex: Influence of Alcoholism and Smoking. 10th International Meeting of the International Society for the Study of Xenobiotics (ISSX), Toronto, Canada, 29 September - 03 October 2013. New York, NY United States: Informa Healthcare.

  • Heim, M., Worrall, S. and Wurst, F. (2014). Urinary ethyl glucuronide and blood phosphatidylethanol values in patients undergoing liver biopsy: (i) relationship with alcohol consumption. 37th Annual Scientific Meeting of the Research Society on Alcoholism (RSA) and 17th Congress of the International Society for Biomedical Research on Alcoholism (ISBRA), Bellevue, WA, USA, 21-25 June, 2014. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1111/acer.12451

  • Heim, M., Worrall, S. and Wurst, F. (2014). Urinary ethyl glucuronide and blood phosphatidylethanol values in patients undergoing liver biopsy: (ii) effect on liver disease. 37th Annual Scientific Meeting of the Research Society on Alcoholism (RSA) and 17th Congress of the International Society for Biomedical Research on Alcoholism (ISBRA), Bellevue, WA, USA, 21-25 June, 2014. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1111/acer.12451

  • Richards, S., Perry, A., Dodd, P. R. and Worrall, S. (2012). Increased protein carbonyl content and elevated adduct formation in alcoholic cerebellar degeneration. 16th World Congress of the International-Society for Biomedical Research on Alcoholism (ISBRA), Sapporo, Japan, 9-12 September 2012. Hoboken, NJ, United States: Wiley-Blackwell. doi: 10.1111/j.1530-0277.2012.01917.x

  • Preedy, Victor R., Peter Eriksson, C. J., Morris, John B., Salaspuro, Mikko, Emery, Peter, Thornalley, Paul J., Seitz, Helmut K., Rao, Radhakrishna K., Worrall, Simon, Apte, Minoti V., Okamura, Tomonori and Yin, Shih-Jiun (2007). Discussion.

  • Quertemont, Etienne, Jamal, Mostofa, Peter Eriksson, C. J., Preedy, Victor R., Worrall, Simon, Deitrich, Richard A., Yin, Shih-Jiun and Apte, Minoti V. (2007). Discussion.

  • Worrall, Simon, Eriksson, C. J. Peter, Preedy, Victor R., Seitz, Helmut K., Salaspuro, Ville, Salaspuro, Mikko, Apte, Minoti V., Rao, Radhakrishna K., Morris, John B., Thornalley, Paul J. and Ren, Jun (2007). Discussion.

  • Deitrich, Richard A., Crabb, David W., Salaspuro, Mikko, Peter Eriksson, C. J., Apte, Minoti V., Emery, Peter, Niemelä, Onni, Worrall, Simon, Thornalley, Paul J., Albano, Emanuele, Seitz, Helmut K. and Shukla, Shivendra D. (2007). Discussion.

  • Seitz, Helmut K., Deitrich, Richard A., Peter Eriksson, C. J., Apte, Minoti V., Preedy, Victor R., Morris, John B., Albano, Emanuele, Worrall, Simon, Emery, Peter, Ren, Jun, Crabb, David W., Salaspuro, Mikko, Quertemont, Etienne, Thornalley, Paul J., Rao, Radhakrishna K., Aranda, Agustin, Okamura, Tomonori, Shukla, Shivendra D., Niemelä, Onni and Jamal, Mostofa (2007). Discussion.

  • Crabb, David W., Seitz, Helmut K., Emery, Peter, Worrall, Simon, Thornalley, Paul J., Rao, Radhakrishna K., Shukla, Shivendra D., Apte, Minoti V., Deitrich, Richard A., Salaspuro, Mikko, Yin, Shih-Jiun, Ren, Jun, Okamura, Tomonori, Eriksson, C. J. Peter, Preedy, Victor R. and Albano, Emanuele (2007). Discussion.

  • Thornalley, Paul J., Worrall, Simon, Niemelä, Onni, Rao, Radhakrishna K., Preedy, Victor R., Apte, Minoti V., Albano, Emanuele and Seitz, Helmut K. (2007). Discussion.

  • Eriksson, C. J. Peter, Preedy, Victor R., Albano, Emanuele, Salaspuro, Mikko, Seitz, Helmut K., Emery, Peter, Apte, Minoti V., Shukla, Shivendra D., Worrall, Simon, Thornalley, Paul J., Rao, Radhakrishna K., Niemelä, Onni, Crabb, David W. and Ren, Jun (2007). Discussion.

  • Worrall, Simon (2007). General discussion. Symposium on Acetaldehyde-related pathology: Bridging the Trans-disciplinary Divide, London, UK, 5-7 September 2006. Chichester, UK: John Wiley.

  • Preedy, Victor R., Hashimoto, Kijiro, Hirano, Makoto, Hunter, Ross, Nakahara, Tatsuo, Niemela, Onni, Parkkila, Seppo and Worrall, Simon (2006). Cellular and molecular changes in rat models of alcoholic cardiomyopathy. World Congress on Alcohol Research, Sydney, Australia, 10-13 Septmeber 2006. Hoboken, NJ, United States: Wiley-Blackwell Publishing, Inc.. doi: 10.1111/j.1530-0277.2006.00197.x

  • Perry, Anthony, Dodd, Peter and Worrall, Simon (2006). Detection of elevated protein modification in alcoholic cerebellar degeneration. 29th Annual Meeting of Research Society on Alcoholism, Sydney, Australia, 10-13 September, 2006. Maryland, USA: Blackwell. doi: 10.1111/j.1530-0277.2006.00197.x

  • Perry, Anthony, Dodd, Peter R. and Worrall, Simon (2006). Detection of elevated protein modification in human cerebellum in alcoholic cerebellar degeneration. 29th Annual Meeting of the Research Society on Alcoholism ( RSA 2006), Baltimore, MD, USA, 23rd- 29th June, 2006. Maryland: John Wiley & Sons, Inc. doi: 10.1111/j.1530-0277.2006.00150.x

  • Worrall, Simon (2006). Hepatic adduct levels do not predict the levels of extrahepatic modification. World Congress on Alcohol Research (ISBRA 2006), Sydney, Australia, 10 - 13 September 2006. Oxford: Blackwell Publishing. doi: 10.1111/j.1530-0277.2006.00197.x

  • Freeman, Thomas L., Tuma, Dean J., Thiele, Geoffrey M., Klassen, Lynell W., Worrall, Simon, Niemela, Onni, Parkkila, Seppo, Emery, Peter W. and Preedy, Victor R. (2005). Recent advances in alcohol-induced adduct formation. 12th International Congress of the International Society for Biomedical Research on Alcoholism, Heidelberg, Germany, 29 September-2 October 2004. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1097/01.ALC.0000171484.52201.52

  • Freeman, TL, Klassen, LW, Worrall, S, Sorrell, MF, Tuma, DJ and Thiele, GM (2004). Adduct chemistry and mechanisms of adduct formation.. 12th International Congress of the International-Society-for-Biomedical-Research-on-Alcoholism, Heidelberg Germany, Sep 29-Oct 02, 2004. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. doi: 10.1097/00000374-200408002-00363

  • Worrall, S (2004). Adduct formation in the liver.. 12th International Congress of the International-Society-for-Biomedical-Research-on-Alcoholism, Heidelberg Germany, Sep 29-Oct 02, 2004. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. doi: 10.1097/00000374-200408002-00365

  • Preedy, VR, Emery, P, Niemela, O, Parkkila, S, Peters, TJ and Worrall, S (2004). Alcoholic skeletal muscle myopathy: A role for protein adducts?. 12th International Congress of the International-Society-for-Biomedical-Research-on-Alcoholism, Heidelberg Germany, Sep 29-Oct 02, 2004. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. doi: 10.1097/00000374-200408002-00367

  • Worrall, S (2004). Liver adduct formation does not predict adduct levels in extrahepatic tissues.. 12th International Congress of the International-Society-for-Biomedical-Research-on-Alcoholism, Heidelberg Germany, Sep 29-Oct 02, 2004. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. doi: 10.1097/00000374-200408002-00010

  • Preedy, VR, Peters, TJ, Adachi, J, Ahmed, S, Mantle, D, Niemela, O, Parkkila, S and Worrall, S (2001). Pathogenic mechanisms in alcoholic myopathy. International Titisee Symposium on Health Effects of Alcohol Intake, Titisee Germany, Dec 09-12, 1999. NEW YORK: MARCEL DEKKER.

  • Worrall, S (2001). Proteins modified by direct and indirect ethanol metabolites, and their associated antibodies, as markers of alcohol intake. 11th World Congress of Psychiatry, Hamburg Germany, Aug 06-11, 1999. BERLIN 33: STEINKOPFF DARMSTADT.

  • Niemlea, O., Parkkila, S. and Worrall, S. (2000). Protein adducts in type I and type II fibre-predominant muscles of the ethanol-fed rat. 10th Congress of the International Society for Biomedical Research on Alcoholism, Yokohama, Japan, 2-8 July, 2000.

  • Worrall, S. (2000). Studies on protein modification by ethanol metabolites in alcohol abuse. Joint Meeting of ASCEPT and the British Pharmacological Society, Monash University, Melbourne, 3-6 December 2000. Melbourne, Vic: Australasian Society of Clinical and Experimental Pharmacologists & Toxicologists.

  • Swagell, C. D., Rothnagel, J. A. and Worrall, S. (2000). The effect of keratin mutants on hepatocytes metabolising ethanol in culture. 10th Congress of the International Society for Biomedical Research on Alcoholism: ISBRA 2000, Yokohama, Japan, 2-8 July 2000.

  • Worrall, Simon (2000). The formation and clearance of MAA adducts in ethanol-fed rats. 10th Congress of the International Society for Biomedical Reseach on Alcoholism, Yokohama, Japan, 2-8 July, 2000. doi: 10.1111/(ISSN)1530-0277

  • Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1991). Acetaldehyde-Modified Proteins and Associated Antibodies in Ethanol-Fed Rats. 5th Congress of the International Soc for Biomedical Research On Alcoholism / 1990 Annual Meeting of the Research On Alcoholism, Toronto Canada, Jun 17-22, 1990. OXFORD: OXFORD UNIV PRESS UNITED KINGDOM.

  • Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1991). Alcohol Abusers Exhibit a Higher Iga Response to Acetaldehyde-Modified Proteins. 5th Congress of the International Soc for Biomedical Research On Alcoholism / 1990 Annual Meeting of the Research On Alcoholism, Toronto Canada, Jun 17-22, 1990. OXFORD: OXFORD UNIV PRESS UNITED KINGDOM.

  • Worrall, S, Dejersey, J, Shanley, BC and Wilce, PA (1990). Detection of Acetaldehyde-Modified Proteins in the Livers of Ethanol-Fed Rats. LONDON: PORTLAND PRESS. doi: 10.1042/bst0180678

  • Williamson, RA, Worrall, S and Strange, PG (1987). Partial-Purification of D2 Dopamine-Receptors From Bovine Brain. LONDON: WALTER DE GRUYTER & CO. doi: 10.1042/bst0151155

  • Worrall, S, Williamson, RA and Strange, PG (1986). Purification of D2-Dopamine Receptors From Bovine Brain. LONDON: PORTLAND PRESS. doi: 10.1042/bst0141138

  • Worrall, S, Williamson, R and Strange, PG (1986). Partial-Purification of D2-Dopamine Receptors From Bovine Brain. BERLIN: PORTLAND PRESS.

PhD and MPhil Supervision

Completed Supervision