The University of Queensland

Triheptanoin in epilepsy and beyond

Borges, Karin (2022). Triheptanoin in epilepsy and beyond. Ketogenic diet and metabolic therapies: expanded roles in health and disease. (pp. 493-507) edited by Susan A. Masino. Oxford, United Kingdom: Oxford University Press.

Dietary management of canine epilepsy

Neal, Elliott S., Xu, Weizhi and Borges, Karin (2022). Dietary management of canine epilepsy. A practical guide to seizure disorders in dogs and cats. (pp. 299-310) edited by Luisa De Risio and Karen Munana. Palm Beach, FL, United States: Edra Publsihing.

Alterations in mitochondrial glucose carbon metabolism in epilepsy and targeted metabolic treatments

Han, Felicity Y., McDonald, Tanya, Xu, Weizhi and Borges, Karin (2021). Alterations in mitochondrial glucose carbon metabolism in epilepsy and targeted metabolic treatments. Clinical bioenergetics: from pathophysiology to clinical translation. (pp. 653-677) edited by Sergej Ostojic. London, United Kingdom: Elsevier. doi: 10.1016/b978-0-12-819621-2.00029-2

Triheptanoin epilepsy and beyond

Borges, Karin (2017). Triheptanoin epilepsy and beyond. Ketogenic diet and metabolic therapies: expanded roles in health and disease. (pp. 336-346) edited by Susan A. Masino. New York NY, USA: Oxford University Press.

High Caloric diets for amyotrophic lateral sclerosis

Ngo, Shyuan T., Steyn, Frederik J., McCombe, Pamela A. and Borges, Karin (2015). High Caloric diets for amyotrophic lateral sclerosis. Bioactive nutraceuticals and dietary supplements in neurological and brain disease: prevention and therapy. (pp. 355-361) edited by Ronald Ross Watson and Victor R. Preedy. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-411462-3.00036-9

Metabolic dysfunctions in epilepsy and novel metabolic treatment approaches

Tan, Kah Ni, McDonald, Tanya S. and Borges, Karin (2015). Metabolic dysfunctions in epilepsy and novel metabolic treatment approaches. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease: Prevention and Therapy. (pp. 461-470) edited by Ronald R Watson and Victor R Preedy. Amsterdam, The Netherlands: Elsevier. doi: 10.1016/B978-0-12-411462-3.00048-5

Transient anticonvulsant effects of time-restricted feeding in the 6-Hz mouse model

Armstrong, Oliver J., Neal, Elliott S., Vidovic, Diana, Xu, Weizhi and Borges, Karin (2024). Transient anticonvulsant effects of time-restricted feeding in the 6-Hz mouse model. Epilepsy & Behavior, 151 109618, 109618. doi: 10.1016/j.yebeh.2023.109618

Brain energy metabolism: A roadmap for future research

Rae, Caroline D., Baur, Joseph A., Borges, Karin, Dienel, Gerald, Díaz‐García, Carlos Manlio, Douglass, Starlette R., Drew, Kelly, Duarte, João M. N., Duran, Jordi, Kann, Oliver, Kristian, Tibor, Lee‐Liu, Dasfne, Lindquist, Britta E., McNay, Ewan C., Robinson, Michael B., Rothman, Douglas L., Rowlands, Benjamin D., Ryan, Timothy A., Scafidi, Joseph, Scafidi, Susanna, Shuttleworth, C. William, Swanson, Raymond A., Uruk, Gökhan, Vardjan, Nina, Zorec, Robert and McKenna, Mary C. (2024). Brain energy metabolism: A roadmap for future research. Journal of Neurochemistry. doi: 10.1111/jnc.16032

Metabolic aspects of genetic ion channel epilepsies

Neal, Elliott S., Xu, Weizhi and Borges, Karin (2023). Metabolic aspects of genetic ion channel epilepsies. Journal of Neurochemistry. doi: 10.1111/jnc.15938

Vitamin B12 deficiency induces glucose intolerance, delays peak insulin levels and promotes ketogenesis in female rats

Neal, Elliott, Kumar, Vinod, Borges, Karin and Cuffe, James S.M. (2023). Vitamin B12 deficiency induces glucose intolerance, delays peak insulin levels and promotes ketogenesis in female rats. The Journal of Endocrinology, 256 (2) e220158, 1-16. doi: 10.1530/joe-22-0158

Glyceryl triacetate feeding in mice increases plasma acetate levels but has no anticonvulsant effects in acute electrical seizure models

Xu, Weizhi, Neal, Elliott S., Plan, Manuel and Borges, Karin (2022). Glyceryl triacetate feeding in mice increases plasma acetate levels but has no anticonvulsant effects in acute electrical seizure models. Epilepsy and Behavior, 137 (Part A) 108964, 108964. doi: 10.1016/j.yebeh.2022.108964

Potential new roles for glycogen in epilepsy

Dienel, Gerald A., Gillinder, Lisa, McGonigal, Aileen and Borges, Karin (2022). Potential new roles for glycogen in epilepsy. Epilepsia, 64 (1), 29-53. doi: 10.1111/epi.17412

β-hydroxybutyrate and medium-chain fatty acids are metabolized by different cell types in mouse cerebral cortex slices

Andersen, Jens V., Westi, Emil W., Neal, Elliott S., Aldana, Blanca I. and Borges, Karin (2022). β-hydroxybutyrate and medium-chain fatty acids are metabolized by different cell types in mouse cerebral cortex slices. Neurochemical Research, 48 (1), 1-8. doi: 10.1007/s11064-022-03726-6

Brain glycogen content is increased in the acute and interictal chronic stages of the mouse pilocarpine model of epilepsy

Young Seo, Gi, Neal, Elliott S., Han, Felicity, Vidovic, Diana, Nooru‐Mohamed, Fathima, Dienel, Gerald A., Sullivan, Mitchell A. and Borges, Karin (2022). Brain glycogen content is increased in the acute and interictal chronic stages of the mouse pilocarpine model of epilepsy. Epilepsia Open, 7 (2), 361-367. doi: 10.1002/epi4.12599

Astrocyte metabolism of the medium-chain fatty acids octanoic acid and decanoic acid promotes GABA synthesis in neurons via elevated glutamine supply

Andersen, Jens V., Westi, Emil W., Jakobsen, Emil, Urruticoechea, Nerea, Borges, Karin and Aldana, Blanca I. (2021). Astrocyte metabolism of the medium-chain fatty acids octanoic acid and decanoic acid promotes GABA synthesis in neurons via elevated glutamine supply. Molecular Brain, 14 (1) 132, 1-13. doi: 10.1186/s13041-021-00842-2

Sustained-release ketamine-loaded lipid-particulate system: in vivo assessment in mice

Xu, Weizhi, Maqbool, Faheem, Kumar, Vinod, Falconer, James R., Cui, Cedric S., Woodruff, Trent M., Borges, Karin, Whittaker, Andrew K., Smith, Maree T. and Han, Felicity Y. (2021). Sustained-release ketamine-loaded lipid-particulate system: in vivo assessment in mice. Drug Delivery and Translational Research, 12 (10), 2518-2526. doi: 10.1007/s13346-021-01093-3

Fructose 1,6-bisphosphate is anticonvulsant and improves oxidative glucose metabolism within the hippocampus and liver in the chronic pilocarpine mouse epilepsy model

McDonald, Tanya S., Neal, Elliott S. and Borges, Karin (2021). Fructose 1,6-bisphosphate is anticonvulsant and improves oxidative glucose metabolism within the hippocampus and liver in the chronic pilocarpine mouse epilepsy model. Epilepsy and Behavior, 122 108223, 1-9. doi: 10.1016/j.yebeh.2021.108223

Dietary medium chain triglycerides for management of epilepsy: new data from human, dog, and rodent studies

Han, Felicity Y., Conboy‐Schmidt, Lisa, Rybachuk, Galena, Volk, Holger A., Zanghi, Brian, Pan, Yuanlong and Borges, Karin (2021). Dietary medium chain triglycerides for management of epilepsy: new data from human, dog, and rodent studies. Epilepsia, 62 (8) epi.16972, 1790-1806. doi: 10.1111/epi.16972

CNS glucose metabolism in amyotrophic lateral sclerosis: a therapeutic target?

Tefera, Tesfaye Wolde, Steyn, Frederik J., Ngo, Shyuan T. and Borges, Karin (2021). CNS glucose metabolism in amyotrophic lateral sclerosis: a therapeutic target?. Cell & Bioscience, 11 (1) 14, 14. doi: 10.1186/s13578-020-00511-2

Open label long term treatment of add-on triheptanoin in adults with drug-resistant epilepsy

Borges, Karin, Kaul, Neha, Germaine, Jack, Carrasco-Pozo, Catalina, Kwan, Patrick and O'Brien, Terence J. (2020). Open label long term treatment of add-on triheptanoin in adults with drug-resistant epilepsy. Epilepsia Open, 5 (2), 230-239. doi: 10.1002/epi4.12391

Combined diffusion tensor imaging and quantitative susceptibility mapping discern discrete facets of white matter pathology post-injury in the rodent brain

Soni, Neha, Vegh, Viktor, To, Xuan Vinh, Mohamed, Abdalla Z., Borges, Karin and Nasrallah, Fatima A. (2020). Combined diffusion tensor imaging and quantitative susceptibility mapping discern discrete facets of white matter pathology post-injury in the rodent brain. Frontiers in Neurology, 11 153, 1-16. doi: 10.3389/fneur.2020.00153

Prenatal betamethasone exposure increases corticotropin-releasing hormone expression along with increased hippocampal slice excitability in the developing hippocampus

Benson, Melissa J., Lauková, Marcela, Borges, Karin, Velíšková, Jana and Velíšek, Libor (2020). Prenatal betamethasone exposure increases corticotropin-releasing hormone expression along with increased hippocampal slice excitability in the developing hippocampus. Epilepsy Research, 160 106276, 106276. doi: 10.1016/j.eplepsyres.2020.106276

Diffusion magnetic resonance imaging unveils the spatiotemporal microstructural gray matter changes following injury in the rodent brain

Soni, Neha, Mohamed, Abdalla Z., Kurniawan, Nyoman D., Borges, Karin and Nasrallah, Fatima (2019). Diffusion magnetic resonance imaging unveils the spatiotemporal microstructural gray matter changes following injury in the rodent brain. Journal of Neurotrauma, 36 (8), 1306-1317. doi: 10.1089/neu.2018.5972

Triheptanoin alters [U- 13 C 6 ]-glucose incorporation into glycolytic intermediates and increases TCA cycling by normalizing the activities of pyruvate dehydrogenase and oxoglutarate dehydrogenase in a chronic epilepsy mouse model

McDonald, Tanya, Hodson, Mark P., Bederman, Ilya, Puchowicz, Michelle and Borges, Karin (2019). Triheptanoin alters [U- 13 C 6 ]-glucose incorporation into glycolytic intermediates and increases TCA cycling by normalizing the activities of pyruvate dehydrogenase and oxoglutarate dehydrogenase in a chronic epilepsy mouse model. Journal of Cerebral Blood Flow and Metabolism, 40 (3), 271678X19837380-691. doi: 10.1177/0271678X19837380

Randomized trial of add-on triheptanoin vs medium chain triglycerides in adults with refractory epilepsy

Borges, Karin, Kaul, Neha, Germaine, Jack, Kwan, Patrick and O'Brien, Terence J. (2019). Randomized trial of add-on triheptanoin vs medium chain triglycerides in adults with refractory epilepsy. Epilepsia Open, 4 (1), 153-163. doi: 10.1002/epi4.12308

Impaired pentose phosphate pathway in the spinal cord of the hSOD1G93A mouse model of amyotrophic lateral sclerosis

Tefera, Tesfaye Wolde, Bartlett, Katherine, Tran, Shirley S., Hodson, Mark P. and Borges, Karin (2019). Impaired pentose phosphate pathway in the spinal cord of the hSOD1G93A mouse model of amyotrophic lateral sclerosis. Molecular Neurobiology, 56 (8), 5844-5855. doi: 10.1007/s12035-019-1485-6

A companion to the preclinical common data elements for physiologic data in rodent epilepsy models. A report of the TASK3 Physiology Working Group of the ILAE/AES Joint Translational Task Force

Gorter, Jan A., van Vliet, Erwin A., Dedeurwaerdere, Stefanie, Buchanan, Gordon F., Friedman, Daniel, Borges, Karin, Grabenstatter, Heidi, Lukasiuk, Katarzyna, Scharfman, Helen E. and Nehlig, Astrid (2018). A companion to the preclinical common data elements for physiologic data in rodent epilepsy models. A report of the TASK3 Physiology Working Group of the ILAE/AES Joint Translational Task Force. Epilepsia Open, 3 (S1), 69-89. doi: 10.1002/epi4.12261

The effect of dichloroacetate in mouse models of epilepsy

Durie, Dylan, McDonald, Tanya S. and Borges, Karin (2018). The effect of dichloroacetate in mouse models of epilepsy. Epilepsy Research, 145, 77-81. doi: 10.1016/j.eplepsyres.2018.06.004

Impairments in oxidative glucose metabolism in epilepsy and metabolic treatments thereof

McDonald, Tanya, Puchowicz, Michelle and Borges, Karin (2018). Impairments in oxidative glucose metabolism in epilepsy and metabolic treatments thereof. Frontiers in Cellular Neuroscience, 12 274, 274. doi: 10.3389/fncel.2018.00274

A pilot study of add-on oral triheptanoin treatment for children with medically refractory epilepsy

Calvert, Sophie, Barwick, Katie, Par, Melody, Ni Tan, Kah and Borges, Karin (2018). A pilot study of add-on oral triheptanoin treatment for children with medically refractory epilepsy. European Journal of Paediatric Neurology, 22 (6), 1074-1080. doi: 10.1016/j.ejpn.2018.07.014

Heptanoate is neuroprotective in vitro but triheptanoin post-treatment did not protect against middle cerebral artery occlusion in rats

Tan, Kah Ni, Hood, Rebecca, Warren, Kirby, Pepperall, Debbie, Carrasco-Pozo, Catalina, Manzanero, Silvia, Borges, Karin and Spratt, Neil J. (2018). Heptanoate is neuroprotective in vitro but triheptanoin post-treatment did not protect against middle cerebral artery occlusion in rats. Neuroscience Letters, 683, 207-214. doi: 10.1016/j.neulet.2018.07.045

Correction: Alterations in Cytosolic and Mitochondrial [U-13C]Glucose Metabolism in a Chronic Epilepsy Mouse Model (vol 4, e0341-16.2017, 2017)

McDonald, Tanya S., Carrasco-Pozo, Catalina, Hodson, Mark P. and Borges, Karin (2018). Correction: Alterations in Cytosolic and Mitochondrial [U-13C]Glucose Metabolism in a Chronic Epilepsy Mouse Model (vol 4, e0341-16.2017, 2017). eNeuro, 5 (2). doi: 10.1523/ENEURO.0154-18.2018

ACTH and PMX53 recover synaptic transcriptome alterations in a rat model of infantile spasms

Iacobaş, Dumitru A., Chachua, Tamar, Iacobaş, Sanda, Benson, Melissa J., Borges, Karin, Velíšková, Jana and Velíšek, Libor (2018). ACTH and PMX53 recover synaptic transcriptome alterations in a rat model of infantile spasms. Scientific Reports, 8 (5722) 5722, 5722. doi: 10.1038/s41598-018-24013-x

Neuronal glucose metabolism is impaired while astrocytic TCA cycling is unaffected at symptomatic stages in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

Tefera, Tesfaye W. and Borges, Karin (2018). Neuronal glucose metabolism is impaired while astrocytic TCA cycling is unaffected at symptomatic stages in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. Journal of Cerebral Blood Flow and Metabolism, 39 (9), 271678X18764775-1724. doi: 10.1177/0271678X18764775

Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration

Tan, Kah Ni, Simmons, David, Carrasco-Pozo, Catalina and Borges, Karin (2018). Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration. Journal of Neurochemistry, 144 (4), 431-442. doi: 10.1111/jnc.14275

Impaired hippocampal glucose metabolism during and after flurothyl-induced seizures in mice: Reduced phosphorylation coincides with reduced activity of pyruvate dehydrogenase

McDonald, Tanya S. and Borges, Karin (2017). Impaired hippocampal glucose metabolism during and after flurothyl-induced seizures in mice: Reduced phosphorylation coincides with reduced activity of pyruvate dehydrogenase. Epilepsia, 58 (7), 1172-1180. doi: 10.1111/epi.13796

Sulforaphane protects against high cholesterol-induced mitochondrial bioenergetics impairments, inflammation, and oxidative stress and preserves pancreatic β-cells function

Carrasco-Pozo, Catalina, Tan, Kah Ni, Gotteland, Martin and Borges, Karin (2017). Sulforaphane protects against high cholesterol-induced mitochondrial bioenergetics impairments, inflammation, and oxidative stress and preserves pancreatic β-cells function. Oxidative Medicine and Cellular Longevity, 2017 3839756, 3839756-14. doi: 10.1155/2017/3839756

The effects of C5aR1 on leukocyte infiltration following pilocarpine-induced status epilepticus

Benson, Melissa J., Manzanero, Silvia and Borges, Karin (2017). The effects of C5aR1 on leukocyte infiltration following pilocarpine-induced status epilepticus. Epilepsia, 58 (4), e54-e58. doi: 10.1111/epi.13698

Alterations in cytosolic and mitochondrial [U-13C] glucose metabolism in a chronic epilepsy mouse model

McDonald, Tanya S., Carrasco-Pozo, Catalina, Hodson, Mark P. and Borges, Karin (2017). Alterations in cytosolic and mitochondrial [U-13C] glucose metabolism in a chronic epilepsy mouse model. eNeuro, 4 (1) e0341-16.2017, ENEURO.0341-16.2017. doi: 10.1523/ENEURO.0341-16.2017

Metabolic dysfunctions in amyotrophic lateral sclerosis pathogenesis and potential metabolic treatments

Tefera, Tesfaye W. and Borges, Karin (2017). Metabolic dysfunctions in amyotrophic lateral sclerosis pathogenesis and potential metabolic treatments. Frontiers in Neuroscience, 10 (JAN) 611, 461-473. doi: 10.3389/fnins.2016.00611

Alternative fuels in epilepsy and amyotrophic lateral sclerosis

Tefera, Tesfaye W. , Tan, Kah Ni, McDonald, Tanya S.  and Borges, Karin (2016). Alternative fuels in epilepsy and amyotrophic lateral sclerosis. Neurochemical Research, 42 (6), 1-11. doi: 10.1007/s11064-016-2106-7

The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic β-cells, glycemic control and inflammation: in vitro and in vivo studies

Carrasco-Pozo, Catalina, Tan, Kah Ni, Reyes-Farias, Marjorie, De La Jara, Nicole, Ngo, Shyuan Thieu, Garcia-Diaz, Diego Fernando, Llanos, Paola, Cires, Maria Jose and Borges, Karin (2016). The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic β-cells, glycemic control and inflammation: in vitro and in vivo studies. Redox Biology, 9, 229-243. doi: 10.1016/j.redox.2016.08.007

Triheptanoin protects motor neurons and delays the onset of motor symptoms in a mouse model of amyotrophic lateral sclerosis

Tefera, Tesfaye W., Wong, Yide, Barkl-Luke, Mallory E., Ngo, Shyuan T., Thomas, Nicola K., McDonald, Tanya S. and Borges, Karin (2016). Triheptanoin protects motor neurons and delays the onset of motor symptoms in a mouse model of amyotrophic lateral sclerosis. Plos One, 11 (8) e0161816, e0161816. doi: 10.1371/journal.pone.0161816

Tridecanoin is anticonvulsant, antioxidant, and improves mitochondrial function

Tan, Kah Ni, Carrasco-Pozo, Catalina, McDonald, Tanya S., Puchowicz, Michelle and Borges, Karin (2016). Tridecanoin is anticonvulsant, antioxidant, and improves mitochondrial function. Journal Of Cerebral Blood Flow and Metabolism, 37 (6), 2035-2048. doi: 10.1177/0271678X16659498

Sulforaphane is anticonvulsant and improves mitochondrial function

Carrasco-Pozo, Catalina, Tan, Kah Ni and Borges, Karin (2015). Sulforaphane is anticonvulsant and improves mitochondrial function. Journal of Neurochemistry, 135 (5), 932-942. doi: 10.1111/jnc.13361

Modification of Astrocyte Metabolism as an Approach to the Treatment of Epilepsy: Triheptanoin and Acetyl-l-Carnitine

Hadera, Mussie Ghezu, McDonald, Tanya, Smeland, Olav B., Meisingset, Tore W., Eloqayli, Haytham, Jaradat, Saied, Borges, Karin and Sonnewald, Ursula (2015). Modification of Astrocyte Metabolism as an Approach to the Treatment of Epilepsy: Triheptanoin and Acetyl-l-Carnitine. Neurochemical Research, 41 (1-2), 86-95. doi: 10.1007/s11064-015-1728-5

Complex alterations in microglial M1/M2 markers during the development of epilepsy in two mouse models

Benson, Melissa J., Manzanero, Silvia and Borges, Karin (2015). Complex alterations in microglial M1/M2 markers during the development of epilepsy in two mouse models. Epilepsia, 56 (6), 895-905. doi: 10.1111/epi.12960

A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models

Benson, Melissa J, Thomas, Nicola K, Talwar, Sahil, Hodson, Mark P, Lynch, Joseph W, Woodruff, Trent M and Borges, Karin (2015). A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models. Neurobiology of Disease, 76, 87-97. doi: 10.1016/j.nbd.2015.02.004

Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epileps

Hadera, Mussie G., Smeland, Olav B., McDonald, Tanya S., Tan, Kah Ni, Sonnewald, Ursula and Borges, Karin (2014). Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epileps. Journal of Neurochemistry, 129 (1), 107-119. doi: 10.1111/jnc.12610

Alterations of hippocampal glucose metabolism by even versus uneven medium chain triglycerides

McDonald, Tanya S., Tan, Kah Ni, Hodson, Mark P. and Borges, Karin (2014). Alterations of hippocampal glucose metabolism by even versus uneven medium chain triglycerides. Journal Of Cerebral Blood Flow and Metabolism, 34 (1), 153-160. doi: 10.1038/jcbfm.2013.184

Slc10A4-what do we know about the function of this "secret ligand carrier" protein?

Borges, Karin (2013). Slc10A4-what do we know about the function of this "secret ligand carrier" protein?. Experimental Neurology, 248, 258-261. doi: 10.1016/j.expneurol.2013.06.019

Anticonvulsant screening of luteolin in four mouse seizure models

Shaikh, Mohd Farooq, Tan, Kah Ni and Borges, Karin (2013). Anticonvulsant screening of luteolin in four mouse seizure models. Neuroscience Letters, 550, 195-199. doi: 10.1016/j.neulet.2013.06.065

Brain mitochondrial metabolic dysfunction and glutamate level reduction in the pilocarpine model of temporal lobe epilepsy in mice

Smeland, Olav B., Hadera, Mussie G., McDonald, Tanya S., Sonnewald, Ursula and Borges, Karin (2013). Brain mitochondrial metabolic dysfunction and glutamate level reduction in the pilocarpine model of temporal lobe epilepsy in mice. Journal of Cerebral Blood Flow and Metabolism, 33 (7), 1090-1097. doi: 10.1038/jcbfm.2013.54

Triheptanoin reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy

Kim, Tae Hwan, Borges, Karin, Petrou, Steven and Reid, Christopher A. (2013). Triheptanoin reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy. Epilepsy Research, 103 (1), 101-105. doi: 10.1016/j.eplepsyres.2012.09.016

Chronic acetyl-L-carnitine alters brain energy metabolism and increases noradrenaline and serotonin content in healthy mice

Smeland, Olav B., Meisingset, Tore W., Borges, Karin and Sonnewald, Ursula (2012). Chronic acetyl-L-carnitine alters brain energy metabolism and increases noradrenaline and serotonin content in healthy mice. Neurochemistry International, 61 (1), 100-107. doi: 10.1016/j.neuint.2012.04.008

Triheptanoin - a medium chain triglyceride with odd chain fatty acids: a new anaplerotic anticonvulsant treatment?

Borges, Karin and Sonnewald, Ursula (2012). Triheptanoin - a medium chain triglyceride with odd chain fatty acids: a new anaplerotic anticonvulsant treatment?. Epilepsy Research, 100 (3), 239-244. doi: 10.1016/j.eplepsyres.2011.05.023

Triheptanoin in acute mouse seizure models

Nicola, Thomas K., Willis, Sarah, Sweetman, Lawrence and Borges, Karin (2012). Triheptanoin in acute mouse seizure models. Epilepsy Research, 99 (3), 312-317. doi: 10.1016/j.eplepsyres.2011.12.013

Protective effect of the ketogenic diet in Scn1a mutant mice

Dutton, Stacey B. B., Sawyer, Nikki T., Kalume, Franck, Jumbo-Lucioni, Patricia, Borges, Karin, Catterall, William A. and Escayg, Andrew (2011). Protective effect of the ketogenic diet in Scn1a mutant mice. Epilepsia, 52 (11), 2050-2056. doi: 10.1111/j.1528-1167.2011.03211.x

The ketogenic diet changes metabolite levels in hippocampal extracellular fluid

Samala, Ramakrishna, Klein, Jochen and Borges, Karin (2011). The ketogenic diet changes metabolite levels in hippocampal extracellular fluid. Neurochemistry International, 58 (1), 5-8. doi: 10.1016/j.neuint.2010.10.011

Anticonvulsant effects of a triheptanoin diet in two mouse chronic seizure models

Willis, Sarah, Stoll, James, Sweetman, Lawrence and Borges, Karin (2010). Anticonvulsant effects of a triheptanoin diet in two mouse chronic seizure models. Neurobiology of Disease, 40 (3), 565-572. doi: 10.1016/j.nbd.2010.07.017

Quantitative transcriptional neuroanatomy of the rat hippocampus: Evidence for wide-ranging, pathway-specific heterogeneity among three principal cell layers

Greene, James G., Borges, Karin and Dingledine, Raymond (2009). Quantitative transcriptional neuroanatomy of the rat hippocampus: Evidence for wide-ranging, pathway-specific heterogeneity among three principal cell layers. Hippocampus, 19 (3), 253-264. doi: 10.1002/hipo.20502

Eicosapentaenoic and docosahexaenoic acids are not anticonvulsant or neuroprotective in acute mouse seizure models

Willis, Sarah, Samala, Ramakrishna, Rosenberger, Thad A. and Borges, Karin (2009). Eicosapentaenoic and docosahexaenoic acids are not anticonvulsant or neuroprotective in acute mouse seizure models. Epilepsia, 50 (1), 138-142. doi: 10.1111/j.1528-1167.2008.01722.x

Mouse models: The ketogenic diet and polyunsaturated fatty acids

Borges, Karin (2008). Mouse models: The ketogenic diet and polyunsaturated fatty acids. Epilepsia, 49 (s8), 64-66. doi: 10.1111/j.1528-1167.2008.01838.x

Anticonvulsant profile of a balanced ketogenic diet in acute mouse seizure models

Samala, Ramakrishna, Willis, Sarah and Borges, Karin (2008). Anticonvulsant profile of a balanced ketogenic diet in acute mouse seizure models. Epilepsy Research, 81 (2-3), 119-127. doi: 10.1016/j.eplepsyres.2008.05.001

Characterisation of osteopontin expression and function after status epilepticus

Borges, Karin, Gearing, Marla, Rittling, Susan, Sorensen, Esben S., Kotloski, Robert, Denhardt, David T. and Dingledine, Raymond (2008). Characterisation of osteopontin expression and function after status epilepticus. Epilepsia, 49 (10), 1675-1685. doi: 10.1111/j.1528-1167.2008.01613.x

Using WebCt to implement a basic science competency education course

Lockman, Paul R., Gaasch, Julie A., Borges, Karin, Ehlo, Alan and Smith, Quentin R. (2008). Using WebCt to implement a basic science competency education course. American Journal of Pharmaceutical Education, 72 (2), Article 39. doi: 10.5688/aj720239

Gene expression changes after seizure preconditioning in the three major hippocampal cell layers

Borges, Karin, Shaw, Renee and Dingledine, Raymond (2007). Gene expression changes after seizure preconditioning in the three major hippocampal cell layers. Neurobiology of Disease, 26 (1), 66-77. doi: 10.1016/j.nbd.2006.12.001

Formulation of spray-dried phenytoin loaded poly(epsilon-caprolactone) microcarrier intended for brain delivery to treat epilepsy

Li, Zhuzhu, Li, Qingxiu, Simon, Sindee, Guven, Necip, Borges, Karin and Youan, Bi-Botti C. (2007). Formulation of spray-dried phenytoin loaded poly(epsilon-caprolactone) microcarrier intended for brain delivery to treat epilepsy. Journal of Pharmaceutical Sciences, 96 (5), 1018-1030. doi: 10.1002/jps.20935

Degeneration and proliferation of astrocytes in the mouse dentate gyrus after pilocarpine-induced status epilepticus

Borges, Karin, McDermott, Dayna, Irier, Hasan, Smith, Yoland and Dingledine, Raymond (2006). Degeneration and proliferation of astrocytes in the mouse dentate gyrus after pilocarpine-induced status epilepticus. Experimental Neurology, 201 (2), 416-427. doi: 10.1016/j.expneurol.2006.04.031

Reciprocal changes of CD44 and GAP-43 expression in the dentate gyrus inner molecular layer after status epilepticus

Borges, Karin, McDermott, Dayna L. and Dingledine, Raymond (2004). Reciprocal changes of CD44 and GAP-43 expression in the dentate gyrus inner molecular layer after status epilepticus. Experimental Neurology, 188 (1), 1-10. doi: 10.1016/j.expneurol.2004.03.019

Activity of the rat GluR4 promoter in transfected cortical neurons and glia

Borges, Karin, Myers, Scott J, Zhang, Sunan and Dingledine, Raymond (2003). Activity of the rat GluR4 promoter in transfected cortical neurons and glia. Journal of Neurochemistry, 86 (5), 1162-1173. doi: 10.1046/j.1471-4159.2003.01926.x

Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model

Borges, Karin, Gearing, Marla, McDermott, Dayna L., Smith, Amy B., Almonte, Antoine G., Wainer, Bruce H. and Dingledine, Raymond (2003). Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model. Experimental Neurology, 182 (1), 21-34. doi: 10.1016/S0014-4886(03)00086-4

Functional Organization of the GluR1 Glutamate Receptor Promoter

Borges, K and Dingledine, R (2001). Functional Organization of the GluR1 Glutamate Receptor Promoter. Journal of Biological Chemistry, 276 (28), 25929-25938. doi: 10.1074/jbc.M009105200

The glutamate receptor ion channels

Dingledine, R, Borges, K, Bowie, D and Traynelis, SF (1999). The glutamate receptor ion channels. Pharmacological Reviews, 51 (1), 7-61.

Genetic regulation of glutamate receptor ion channels

Myers, SJ, Dingledine, R and Borges, K (1999). Genetic regulation of glutamate receptor ion channels. Annual Review of Pharmacology and Toxicology, 39 (1), 221-241. doi: 10.1146/annurev.pharmtox.39.1.221

AMPA receptors: Molecular and functional diversity

Borges, K and Dingledine, R (1998). AMPA receptors: Molecular and functional diversity. Glutamate Synapse as a Therapeutical Target: Molecular Organization and Pathology of the Glutamate Synapse, 116, 153-170. doi: 10.1016/S0079-6123(08)60436-7

Blockade of K+ Channels Induced by Ampa Kainate Receptor Activation in Mouse Oligodendrocyte Precursor Cells Is Mediated by Na+ Entry

Borges, K and Kettenmann, H (1995). Blockade of K+ Channels Induced by Ampa Kainate Receptor Activation in Mouse Oligodendrocyte Precursor Cells Is Mediated by Na+ Entry. Journal of Neuroscience Research, 42 (4), 579-593. doi: 10.1002/jnr.490420416

Adult-Rat Optic-Nerve Oligodendrocyte Progenitor Cells Express a Distinct Repertoire of Voltage-Gated and Ligand-Gated Ion Channels

Borges, K, Wolswijk, G, Ohlemeyer, C and Kettenmann, H (1995). Adult-Rat Optic-Nerve Oligodendrocyte Progenitor Cells Express a Distinct Repertoire of Voltage-Gated and Ligand-Gated Ion Channels. Journal of Neuroscience Research, 40 (5), 591-605. doi: 10.1002/jnr.490400504

Ampa Kainate Receptor Activation in Murine Oligodendrocyte Precursor Cells Leads to Activation of a Cation Conductance, Calcium Influx and Blockade of Delayed Rectifying K+ Channels

Borges, K, Ohlemeyer, C, Trotter, J and Kettenmann, H (1994). Ampa Kainate Receptor Activation in Murine Oligodendrocyte Precursor Cells Leads to Activation of a Cation Conductance, Calcium Influx and Blockade of Delayed Rectifying K+ Channels. Neuroscience, 63 (1), 135-149. doi: 10.1016/0306-4522(94)90012-4

Anaplerotic triheptanoin preserves mitochondrial function and reduces oxidative stress in pilocarpine-induced status epilepticus

Tan, K. N., Carrasco-Pozo, C. and Borges, K. (2017). Anaplerotic triheptanoin preserves mitochondrial function and reduces oxidative stress in pilocarpine-induced status epilepticus. 28th International Symposium on Cerebral Blood Flow, Metabolism and Function / 13th International Conference on Quantification of Brain Function with PET, Berlin, Germany, 1-4 April 2017. London, United Kingdom: Sage Publications.

Cortical neuronal glucose metabolism is impaired at mid stage in the hSOD1(G93A) mouse model of amyotrophic lateral sclerosis

Tefera, T. and Borges, K. (2017). Cortical neuronal glucose metabolism is impaired at mid stage in the hSOD1(G93A) mouse model of amyotrophic lateral sclerosis. ISN-ESN Meeting, Paris, France, 20-24 August 2017. Chichester, West Sussex, United Kingdom: Wiley-Blackwell .

Tricaprin - a new anticonvulsant with multiple mechanisms of actions

Borges, K., Tan, K. N. and Carrasco, C. (2015). Tricaprin - a new anticonvulsant with multiple mechanisms of actions. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13188

Triheptanoin alters anaplerosis and glutamate production in the chronic pilocarpine model of epilepsy

McDonald, Tanya, Hodson, Mark and Borges, Karin (2014). Triheptanoin alters anaplerosis and glutamate production in the chronic pilocarpine model of epilepsy. EB2014: Experimental Biology 2014, San Diago, CA United States, 26-30 April, 2014. Bethesda, MD United States: Federation of American Societies for Experimental Biology.

Mitochondrial metabolic dysfunction and glutamate reduction in the pilocarpine model of temporal lobe epilepsy in mice

Smeland, O. B., Hadera, M. G., McDonald, T., Sonnewald, U. and Borges, K. (2013). Mitochondrial metabolic dysfunction and glutamate reduction in the pilocarpine model of temporal lobe epilepsy in mice. 24th Biennial Meeting of the International Society for Neurochemistry and the American Society for Neurochemistry, Cancun Mexico, 20-24 Apr 2013. United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.12186

The Anticonvulsant Triheptanoin Shows Anaplerotic Activity in the Pilocarpine Model of Temporal Lobe Epilepsy in Mice

Smeland, O. B., Hadera, M., McDonald, T., Sonnewald, U. and Borges, K. (2013). The Anticonvulsant Triheptanoin Shows Anaplerotic Activity in the Pilocarpine Model of Temporal Lobe Epilepsy in Mice. 30th International Epilepsy Congress, Montreal Canada, 23 - 27 June 2013. Hoboken, NJ United States: Wiley-Blackwell Publishing, Inc.. doi: 10.1111/epi.12248

Anti-epileptic effects of an anaplerotic diet in two chronic mouse epilepsy models

Borges, K., Willis, S., Sweetman, L. and Stoll, J. (2009). Anti-epileptic effects of an anaplerotic diet in two chronic mouse epilepsy models. 63rd Annual Meeting of the American-Epilepsy-Society, Boston MA, 4-8 December 2009. MALDEN: WILEY-BLACKWELL PUBLISHING, INC. doi: 10.1111/j.1528-1167.2009.02377_1.x

Anti-epileptic effects of triheptanoin in two chronic mouse epilepsy models

Borges, K., Thomas, N. K., Stoll, J. and Seth, S. (2009). Anti-epileptic effects of triheptanoin in two chronic mouse epilepsy models. 24th ESA Annual Scientific Meeting, Perth, Australia, 2-4 November 2009.

Brain Metabolic Changes in Mice On the Ketogenic Diet

Borges, Karin, Willis, S. and Samala, R. (2008). Brain Metabolic Changes in Mice On the Ketogenic Diet. 62nd Annual Meeting of the American-Epilepsy-Society, Seattle Wa, Dec 05-09, 2008. MALDEN: WILEY-BLACKWELL PUBLISHING, INC.

Characterization of the ketogenic diet in mice

Borges, Karin, Willis, S. and Samala, R. (2007). Characterization of the ketogenic diet in mice. 61st Annual Meeting of the American-Epilepsy-Society, Philadelphia Pa, Nov 13-Dec 04, 2007. OXFORD: BLACKWELL PUBLISHING.

Altered brain extracellular fluid composition pointing to changes in brain metabolism in mice on the ketogenic diet

Pulse, Clayton B. and Borges, Karin (2006). Altered brain extracellular fluid composition pointing to changes in brain metabolism in mice on the ketogenic diet. 60th Annual Meeting of the American-Epilepsy-Society, San Diego Ca, Dec 01-05, 2006. OXFORD: BLACKWELL PUBLISHING.

Comparison of two schemes for automatic keyword extraction from MEDLINE for functional gene clustering

Liu, Ying, Ciliax, Brian J., Borges, Karin, Dasigi, Venu, Ram, Ashwin, Navathe, Shamkant B. and Dingledine, Ray (2004). Comparison of two schemes for automatic keyword extraction from MEDLINE for functional gene clustering. The Computational Systems Bioinformatics Conference CSB2004, Stanford, CA, U.S.A., 16-19 August 2004. Piscataway, NJ, U.S.A.: IEEE. doi: 10.1109/CSB.2004.1332452

Comparison of two schemes for automatic keyword extraction from MEDLINE for functional gene clustering

Liu, Y, Ciliax, BJ, Borges, K, Dasigi, , Ram, A, Navathe, SB and Dingledine, R (2004). Comparison of two schemes for automatic keyword extraction from MEDLINE for functional gene clustering. IEEE Computational Systems Bioinformatics Conference (CSB 2004), Stanford Ca, Aug 16-19, 2004. LOS ALAMITOS: IEEE COMPUTER SOC. doi: 10.1109/ICWS.2004.1314763