The University of Queensland

Endothelial specific GTPase signaling during leukocyte extravasation

Morsing, Sofia, Schimmel, Lilian, Rijssel, Jos van and van Buul, Jaap D. (2018). Endothelial specific GTPase signaling during leukocyte extravasation. Rho GTPases: Molecular Biology in Health and Disease. (pp. 177-199) edited by Philippe Fort and Anne Blangy. New Jersey, United States: World Scientifc Publishing. doi: 10.1142/9789813228795_0010

Epithelial cell spreading assay on E-cadherin-coated glass or PDMS substrates for microscopy-based analysis of cadherin adhesions

Schimmel, Lilian and Noordstra, Ivar (2023). Epithelial cell spreading assay on E-cadherin-coated glass or PDMS substrates for microscopy-based analysis of cadherin adhesions. STAR Protocols, 4 (4) 102626, 102626. doi: 10.1016/j.xpro.2023.102626

An E-cadherin-actin clutch translates the mechanical force of cortical flow for cell-cell contact to inhibit epithelial cell locomotion

Noordstra, Ivar, Hermoso, Mario Díez, Schimmel, Lilian, Bonfim-Melo, Alexis, Currin-Ross, Denni, Duong, Cao Nguyen, Kalappurakkal, Joseph Mathew, Morris, Richard G., Vestweber, Dietmar, Mayor, Satyajit, Gordon, Emma, Roca-Cusachs, Pere and Yap, Alpha S. (2023). An E-cadherin-actin clutch translates the mechanical force of cortical flow for cell-cell contact to inhibit epithelial cell locomotion. Developmental Cell, 58 (18), 1748-1763.e6. doi: 10.1016/j.devcel.2023.06.011

Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis

Jin, Yi, Ding, Yindi, Richards, Mark, Kaakinen, Mika, Giese, Wolfgang, Baumann, Elisabeth, Szymborska, Anna, Rosa, André, Nordling, Sofia, Schimmel, Lilian, Akmeriç, Emir Bora, Pena, Andreia, Nwadozi, Emmanuel, Jamalpour, Maria, Holstein, Katrin, Sáinz-Jaspeado, Miguel, Bernabeu, Miguel O., Welsh, Michael, Gordon, Emma, Franco, Claudio A., Vestweber, Dietmar, Eklund, Lauri, Gerhardt, Holger and Claesson-Welsh, Lena (2022). Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis. Nature Cardiovascular Research, 1 (12), 1156-1173+. doi: 10.1038/s44161-022-00172-z

Endothelial cells are not productively infected by SARS‐CoV‐2

Schimmel, Lilian, Chew, Keng Yih, Stocks, Claudia J., Yordanov, Teodor E., Essebier, Patricia, Kulasinghe, Arutha, Monkman, James, Santos Miggiolaro, Anna Flavia Ribeiro, Cooper, Caroline, Noronha, Lucia, Schroder, Kate, Lagendijk, Anne Karine, Labzin, Larisa I., Short, Kirsty R. and Gordon, Emma J. (2021). Endothelial cells are not productively infected by SARS‐CoV‐2. Clinical and Translational Immunology, 10 (10) e1350, e1350. doi: 10.1002/cti2.1350

Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration

Arts, Janine J. G., Mahlandt, Eike K., Grönloh, Max, Schimmel, Lilian, Noordstra, Ivar, Gordon, Emma, van Steen, Abraham C.I., Tol, Simon, Walzog, Barbara, van Rijssel, Jos, Nolte, Martijn A., Postma, Marten, Khuon, Satya, Heddleston, John M., Wait, Eric, Chew, Teng Leong, Winter, Mark, Montanez, Eloi, Goedhart, Joachim and van Buul, Jaap D. (2021). Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration. eLife, 10 e66074. doi: 10.7554/elife.66074

Endothelial focal adhesions are functional obstacles for leukocytes during basolateral crawling

Arts, Janine J. G., Mahlandt, Eike K., Schimmel, Lilian, Grönloh, Max L. B., van der Niet, Sanne, Klein, Bart J. A. M., Fernandez-Borja, Mar, van Geemen, Daphne, Huveneers, Stephan, van Rijssel, Jos, Goedhart, Joachim and van Buul, Jaap D. (2021). Endothelial focal adhesions are functional obstacles for leukocytes during basolateral crawling. Frontiers in Immunology, 12 667213, 1-14. doi: 10.3389/fimmu.2021.667213

The importance of mechanical forces for in vitro endothelial cell biology

Gordon, Emma, Schimmel, Lilian and Frye, Maike (2020). The importance of mechanical forces for in vitro endothelial cell biology. Frontiers in Physiology, 11 684, 684. doi: 10.3389/fphys.2020.00684

c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly

Schimmel, Lilian, Fukuhara, Daisuke, Richards, Mark, Jin, Yi, Essebier, Patricia, Frampton, Emmanuelle, Hedlund, Marie, Dejana, Elisabetta, Claesson-Welsh, Lena and Gordon, Emma (2020). c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly. Development, 147 (7) 185405, dev.185405. doi: 10.1242/dev.185405

DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis

van der Stoel, Miesje, Schimmel, Lilian, Nawaz, Kalim, van Stalborch, Anne-Marieke, de Haan, Annett, Klaus-Bergmann, Alexandra, Valent, Erik T., Koenis, Duco S., van Nieuw Amerongen, Geerten P., de Vries, Carlie J., de Waard, Vivian, Gloerich, Martijn, van Buul, Jaap D. and Huveneers, Stephan (2020). DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis. Journal of Cell Science, 133 (3) jcs239947, jcs239947. doi: 10.1242/jcs.239947

The precise molecular signals that control endothelial cell–cell adhesion within the vessel wall

Schimmel, Lilian and Gordon, Emma (2018). The precise molecular signals that control endothelial cell–cell adhesion within the vessel wall. Biochemical Society Transactions, 46 (6), 1673-1680. doi: 10.1042/bst20180377

Stiffness-induced endothelial DLC-1 expression forces leukocyte spreading through stabilization of the ICAM-1 adhesome

Schimmel, Lilian, van der Stoel, Miesje, Rianna, Carmela, van Stalborch, Anne-Marieke, de Ligt, Aafke, Hoogenboezem, Mark, Tol, Simon, van Rijssel, Jos, Szulcek, Robert, Bogaard, Harm Jan, Hofmann, Patrick, Boon, Reinier, Radmacher, Manfred, de Waard, Vivian, Huveneers, Stephan and van Buul, Jaap D. (2018). Stiffness-induced endothelial DLC-1 expression forces leukocyte spreading through stabilization of the ICAM-1 adhesome. Cell Reports, 24 (12), 3115-3124. doi: 10.1016/j.celrep.2018.08.045

Endothelial RhoB and RhoC are dispensable for leukocyte diapedesis and for maintaining vascular integrity during diapedesis

Schimmel, Lilian, de Ligt, Aafke, Tol, Simon, de Waard, Vivian and van Buul, Jaap D (2017). Endothelial RhoB and RhoC are dispensable for leukocyte diapedesis and for maintaining vascular integrity during diapedesis. Small GTPases, 11 (3), 1-8. doi: 10.1080/21541248.2017.1377815

Leukocyte transendothelial migration: a local affair

Schimmel, Lilian, Heemskerk, Niels and van Buul, Jaap D. (2016). Leukocyte transendothelial migration: a local affair. Small GTPases, 8 (1), 1-15. doi: 10.1080/21541248.2016.1197872

F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling

Heemskerk, Niels, Schimmel, Lilian, Oort, Chantal, van Rijssel, Jos, Yin, Taofei, Ma, Bin, van Unen, Jakobus, Pitter, Bettina, Huveneers, Stephan, Goedhart, Joachim, Wu, Yi, Montanez, Eloi, Woodfin, Abigail and van Buul, Jaap D. (2016). F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling. Nature Communications, 7 (1) 10493. doi: 10.1038/ncomms10493