The University of Queensland

Future directions in genetics of psychiatric disorders

Wray, Naomi R., Byrne, Enda M., Stringer, Sven and Mowry, Bryan J. (2014). Future directions in genetics of psychiatric disorders. Behavior genetics of psychopathology. (pp. 311-337) edited by Soo Hyun Rhee and Angelica Ronald. New York, NY, United States: Springer New York. doi: 10.1007/978-1-4614-9509-3_11

Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression

Crouse, Jacob J., Park, Shin Ho, Byrne, Enda M., Mitchell, Brittany L., Scott, Jan, Medland, Sarah E., Lin, Tian, Wray, Naomi R., Martin, Nicholas G. and Hickie, Ian B. (2024). Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression. Molecular Psychiatry, 1-9. doi: 10.1038/s41380-024-02492-x

Comprehensive sex-stratified genetic analysis of 28 blood biomarkers and depression reveals a significant association between depression and low levels of total protein in females

Kiewa, Jacqueline, Meltzer-Brody, Samantha, Milgrom, Jeannette, Guintivano, Jerry, Hickie, Ian B, Whiteman, David C, Olsen, Catherine M, Medland, Sarah E, Martin, Nicholas G, Wray, Naomi R and Byrne, Enda M (2024). Comprehensive sex-stratified genetic analysis of 28 blood biomarkers and depression reveals a significant association between depression and low levels of total protein in females. Complex Psychiatry. doi: 10.1159/000538058

Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference

Meng, Xiangrui, Navoly, Georgina, Giannakopoulou, Olga, Levey, Daniel F., Koller, Dora, Pathak, Gita A., Koen, Nastassja, Lin, Kuang, Adams, Mark J., Rentería, Miguel E., Feng, Yanzhe, Gaziano, J. Michael, Stein, Dan J., Zar, Heather J., Campbell, Megan L., van Heel, David A., Trivedi, Bhavi, Finer, Sarah, McQuillin, Andrew, Bass, Nick, Chundru, V. Kartik, Martin, Hilary C., Huang, Qin Qin, Valkovskaya, Maria, Chu, Chia-Yi, Kanjira, Susan, Kuo, Po-Hsiu, Chen, Hsi-Chung, Tsai, Shih-Jen ... BioBank Japan Project (2024). Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference. Nature Genetics, 56 (2), 222-233. doi: 10.1038/s41588-023-01596-4

Evening chronotypes with depression report poorer outcomes of SSRIs: A survey-based study of self-ratings

Crouse, Jacob J., Park, Shin Ho, Byrne, Enda M., Mitchell, Brittany L., Chan, Karina, Scott, Jan, Medland, Sarah E., Martin, Nicholas G., Wray, Naomi R. and Hickie, Ian B. (2024). Evening chronotypes with depression report poorer outcomes of SSRIs: A survey-based study of self-ratings. Biological Psychiatry. doi: 10.1016/j.biopsych.2023.12.023

Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression

Guintivano, Jerry, Byrne, Enda M., Kiewa, Jacqueline, Yao, Shuyang, Bauer, Anna E., Aberg, Karolina A., Adams, Mark J., Campbell, Archie, Campbell, Megan L., Choi, Karmel W., Corfield, Elizabeth C., Havdahl, Alexandra, Hucks, Donald, Koen, Nastassja, Lu, Yi, Maegbaek, Merete L., Mullaer, Jimmy, Peterson, Roseann E., Raffield, Laura M., Sallis, Hannah M., Sealock, Julia M., Walker, Alicia, Watson, Hunna J., Xiong, Ying, Yang, Jessica M. K., Anney, Richard J. L., Gordon-Smith, Katherine, Hubbard, Leon, Jones, Lisa A. ... Sullivan, Patrick (2023). Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression. American Journal of Psychiatry, 180 (12), 884-895. doi: 10.1176/appi.ajp.20230053

Discontinuation of antidepressant treatment: a retrospective cohort study on more than 20,000 participants

Garcia-Marin, Luis M., Mulcahy, Aoibhe, Byrne, Enda M., Medland, Sarah E., Wray, Naomi R., Chafota, Freddy, Lind, Penelope A., Martin, Nicholas G., Hickie, Ian B., Rentería, Miguel E. and Campos, Adrian I. (2023). Discontinuation of antidepressant treatment: a retrospective cohort study on more than 20,000 participants. Annals of General Psychiatry, 22 (1) 49, 49. doi: 10.1186/s12991-023-00480-z

A Common Genetic Factor Underlies Genetic Risk for Gynaecological and Reproductive Disorders and Is Correlated with Risk to Depression

Kiewa, Jacqueline, Mortlock, Sally, Meltzer-Brody, Samantha, Middeldorp, Christel, Wray, Naomi R. and Byrne, Enda M. (2023). A Common Genetic Factor Underlies Genetic Risk for Gynaecological and Reproductive Disorders and Is Correlated with Risk to Depression. Neuroendocrinology, 113 (10), 1059-1075. doi: 10.1159/000533413

Using electronic health record data to predict future self‐harm or suicidal ideation in young people treated by child and youth mental health services

Tennakoon, Gayani, Byrne, Enda M., Vaithianathan, Rhema and Middeldorp, Christel M. (2023). Using electronic health record data to predict future self‐harm or suicidal ideation in young people treated by child and youth mental health services. Suicide and Life-Threatening Behavior, 53 (5), 853-869. doi: 10.1111/sltb.12988

The association between trauma exposure, polygenic risk and individual depression symptoms

Thorp, Jackson G., Gerring, Zachary F., Colodro-Conde, Lucía, Byrne, Enda M., Medland, Sarah E., Middeldorp, Christel M. and Derks, Eske M. (2023). The association between trauma exposure, polygenic risk and individual depression symptoms. Psychiatry Research, 321 115101, 1-8. doi: 10.1016/j.psychres.2023.115101

Phenotypic and genetic factors associated with donation of DNA and consent to record linkage for prescription history in the Australian Genetics of Depression Study

Gomez, Lina, Díaz-Torres, Santiago, Colodro-Conde, Lucía, Garcia-Marin, Luis M., Yap, Chloe X., Byrne, Enda M., Yengo, Loic, Lind, Penelope A., Wray, Naomi R., Medland, Sarah E., Hickie, Ian B., Lupton, Michelle K., Rentería, Miguel E., Martin, Nicholas G. and Campos, Adrian I. (2022). Phenotypic and genetic factors associated with donation of DNA and consent to record linkage for prescription history in the Australian Genetics of Depression Study. European Archives of Psychiatry and Clinical Neuroscience, 273 (6), 1359-1368. doi: 10.1007/s00406-022-01527-0

Corrigendum: Potential genetic overlap between insomnia and sleep symptoms in major depressive disorder: A polygenic risk score analysis(Front. Psychiatry, (2021), 12, (734077), 10.3389/fpsyt.2021.734077)

Melhuish Beaupre, Lindsay M., Tiwari, Arun K., Gonçalves, Vanessa F., Zai, Clement C., Marshe, Victoria S., Lewis, Cathryn M., Martin, Nicholas G., McIntosh, Andrew M., Adams, Mark J., Baune, Bernhard T., Levinson, Doug F., Boomsma, Dorret I., Penninx, Brenda W. J. H., Breen, Gerome, Hamilton, Steve, Awasthi, Swapnil, Ripke, Stephan, Jones, Lisa, Jones, Ian, Byrne, Enda M., Hickie, Ian B., Potash, James P., Shi, Jianxin, Weissman, Myrna M., Milaneschi, Yuri, Shyn, Stanley I., Geus, Eco J. C. de, Willemsen, Gonneke, Brown, Gregory M. and Kennedy, James L. (2022). Corrigendum: Potential genetic overlap between insomnia and sleep symptoms in major depressive disorder: A polygenic risk score analysis(Front. Psychiatry, (2021), 12, (734077), 10.3389/fpsyt.2021.734077). Frontiers in Psychiatry, 13 893816, 893816. doi: 10.3389/fpsyt.2022.893816

Clinical, demographic, and genetic risk factors of treatment‐attributed suicidality in >10,000 Australian adults taking antidepressants

Campos, Adrian I., Byrne, Enda M., Iorfino, Frank, Fabbri, Chiara, Hickie, Ian B., Lewis, Cathryn M., Wray, Naomi R., Medland, Sarah E., Rentería, Miguel E. and Martin, Nicholas G. (2022). Clinical, demographic, and genetic risk factors of treatment‐attributed suicidality in >10,000 Australian adults taking antidepressants. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 189 (6), 196-206. doi: 10.1002/ajmg.b.32913

Lifetime prevalence and correlates of perinatal depression in a case-cohort study of depression

Kiewa, Jacqueline, Meltzer-Brody, Samantha, Milgrom, Jeannette, Bennett, Elizabeth, Mackle, Tracey, Guintivano, Jerry, Hickie, Ian B, Colodro-Conde, Lucia, Medland, Sarah E, Martin, Nick, Wray, Naomi and Byrne, Enda (2022). Lifetime prevalence and correlates of perinatal depression in a case-cohort study of depression. BMJ Open, 12 (8) e059300, 1-7. doi: 10.1136/bmjopen-2021-059300

Dynamic networks of psychological symptoms, impairment, substance use, and social support: the evolution of psychopathology among emerging adults

Crouse, Jacob J., Ho, Nicholas, Scott, Jan, Parker, Richard, Park, Shin Ho, Couvy-Duchesne, Baptiste, Mitchell, Brittany, Byrne, Enda M., Hermens, Daniel F., Medland, Sarah E., Martin, Nicholas G., Gillespie, Nathan A. and Hickie, Ian B. (2022). Dynamic networks of psychological symptoms, impairment, substance use, and social support: the evolution of psychopathology among emerging adults. European Psychiatry, 65 (1) e32, 1-24. doi: 10.1192/j.eurpsy.2022.23

Multi-trait genetic analysis identifies auto-immune loci associated with cutaneous melanoma

Liyanage, Upekha, MacGregor, Stuart, Bishop, D. Timothy, Shi, Jianxin, An, Jiyuan, Ong, Jue Sheng, Han, Xikun, Scolyer, Richard A., Martin, Nicholas G., Medland, Sarah E., Byrne, Enda M., Green, Adèle C., Saw, Robyn P. M., Thompson, John F., Stretch, Jonathan, Spillane, Andrew, Jiang, Yunxuan, Tian, Chao, 23andMe Research Team, Gordon, Scott G., Duffy, David L., Olsen, Catherine M., Whiteman, David C., Long, Georgina V., Iles, Mark M., Landi, Maria Teresa and Law, Matthew H. (2022). Multi-trait genetic analysis identifies auto-immune loci associated with cutaneous melanoma. The Journal of Investigative Dermatology, 142 (6), 1607-1616. doi: 10.1016/j.jid.2021.08.449

Identifying the Common Genetic Basis of Antidepressant Response

Pain, Oliver, Hodgson, Karen, Trubetskoy, Vassily, Ripke, Stephan, Marshe, Victoria S., Adams, Mark J., Byrne, Enda M., Campos, Adrian I., Carrillo-Roa, Tania, Cattaneo, Annamaria, Als, Thomas D., Souery, Daniel, Dernovsek, Mojca Z., Fabbri, Chiara, Hayward, Caroline, Henigsberg, Neven, Hauser, Joanna, Kennedy, James L., Lenze, Eric J., Lewis, Glyn, Müller, Daniel J., Martin, Nicholas G., Mulsant, Benoit H., Mors, Ole, Perroud, Nader, Porteous, David J., Rentería, Miguel E., Reynolds, Charles F., Rietschel, Marcella ... Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2022). Identifying the Common Genetic Basis of Antidepressant Response. Biological Psychiatry Global Open Science, 2 (2), 115-126. doi: 10.1016/j.bpsgos.2021.07.008

Perinatal depression is associated with a higher polygenic risk for major depressive disorder than non-perinatal depression

Kiewa, Jacqueline, Meltzer‐Brody, Samantha, Milgrom, Jeanette, Guintivano, Jerry, Hickie, Ian B., Whiteman, David C., Olsen, Catherine M., Colodro‐Conde, Lucía, Medland, Sarah E., Martin, Nicholas G., Wray, Naomi R. and Byrne, Enda M. (2022). Perinatal depression is associated with a higher polygenic risk for major depressive disorder than non-perinatal depression. Depression and Anxiety, 39 (3), 182-191. doi: 10.1002/da.23232

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders, and known risk factors

Mullins, Niamh, Kang, JooEun, Campos, Adrian I., Coleman, Jonathan R I, Edwards, Alexis C., Galfalvy, Hanga, Levey, Daniel F., Lori, Adriana, Shabalin, Andrey, Starnawska, Anna, Su, Mei-Hsin, Watson, Hunna J., Adams, Mark, Awasthi, Swapnil, Gandal, Michael, Hafferty, Jonathan D., Hishimoto, Akitoyo, Kim, Minsoo, Okazaki, Satoshi, Otsuka, Ikuo, Ripke, Stephan, Ware, Erin B., Bergen, Andrew W., Berrettini, Wade H., Bohus, Martin, Brandt, Harry, Chang, Xiao, Chen, Wei J., Chen, Hsi-Chung ... Ruderfer, Douglas M. (2022). Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders, and known risk factors. Biological Psychiatry, 91 (3), 313-327. doi: 10.1016/j.biopsych.2021.05.029

Impact of CYP2C19 metaboliser status on SSRI response: a retrospective study of 9500 participants of the Australian Genetics of Depression Study

Campos, Adrian I., Byrne, Enda M., Mitchell, Brittany L., Wray, Naomi R., Lind, Penelope A., Licinio, Julio, Medland, Sarah E., Martin, Nicholas G., Hickie, Ian B. and Rentería, Miguel E. (2022). Impact of CYP2C19 metaboliser status on SSRI response: a retrospective study of 9500 participants of the Australian Genetics of Depression Study. The Pharmacogenomics Journal, 22 (2), 130-135. doi: 10.1038/s41397-022-00267-7

Potential genetic overlap between insomnia and sleep symptoms in major depressive disorder: a polygenic risk score analysis

Melhuish Beaupre, Lindsay M., Tiwari, Arun K., Gonçalves, Vanessa F., Zai, Clement C., Marshe, Victoria S., Lewis, Cathryn M., Martin, Nicholas G., McIntosh, Andrew M., Adams, Mark J., Baune, Bernhard T., Levinson, Doug F., Boomsma, Dorret I., Penninx, Brenda W. J. H., Breen, Gerome, Hamilton, Steve, Awasthi, Swapnil, Ripke, Stephan, Jones, Lisa, Jones, Ian, Byrne, Enda M., Hickie, Ian B., Potash, James P., Shi, Jianxin, Weissman, Myrna M., Milaneschi, Yuri, Shyn, Stanley I., Geus, Eco J. C. de, Willemsen, Gonneke, Brown, Gregory M. and Kennedy, James L. (2021). Potential genetic overlap between insomnia and sleep symptoms in major depressive disorder: a polygenic risk score analysis. Frontiers in Psychiatry, 12 734077, 734077. doi: 10.3389/fpsyt.2021.734077

Understanding genetic risk factors for common side effects of antidepressant medications

Campos, Adrian I., Mulcahy, Aoibhe, Thorp, Jackson G., Wray, Naomi R., Byrne, Enda M., Lind, Penelope A., Medland, Sarah E., Martin, Nicholas G., Hickie, Ian B. and Rentería, Miguel E. (2021). Understanding genetic risk factors for common side effects of antidepressant medications. Communications Medicine, 1 (1) 45, 1-10. doi: 10.1038/s43856-021-00046-8

The Australian Genetics of Depression Study: new risk loci and dissecting heterogeneity between subtypes

Mitchell, Brittany L., Campos, Adrian I., Whiteman, David C., Olsen, Catherine M., Gordon, Scott D., Walker, Adam J., Dean, Olivia M., Berk, Michael, Hickie, Ian B., Medland, Sarah E., Wray, Naomi R., Martin, Nicholas G. and Byrne, Enda M. (2021). The Australian Genetics of Depression Study: new risk loci and dissecting heterogeneity between subtypes. Biological Psychiatry, 92 (3), 227-235. doi: 10.1016/j.biopsych.2021.10.021

Genetic and environmental influences on sleep-wake behaviours in adolescence

O'Callaghan, Victoria S., Hansell, Narelle K., Guo, Wei, Carpenter, Joanne S., Shou, Haochang, Strike, Lachlan T., Crouse, Jacob J., McAloney, Kerrie, McMahon, Katie L., Byrne, Enda M., Burns, Jane M., Martin, Nicholas G., Hickie, Ian B., Merikangas, Kathleen R. and Wright, Margaret J. (2021). Genetic and environmental influences on sleep-wake behaviours in adolescence. Sleep Advances, 2 (1) zpab018, zpab018. doi: 10.1093/sleepadvances/zpab018

Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk

Miles, Amy E., Dos Santos, Fernanda C., Byrne, Enda M., Renteria, Miguel E., McIntosh, Andrew M., Adams, Mark J., Pistis, Giorgio, Castelao, Enrique, Preisig, Martin, Baune, Bernhard T., Schubert, K. Oliver, Lewis, Cathryn M., Jones, Lisa A., Jones, Ian, Uher, Rudolf, Smoller, Jordan W., Perlis, Roy H., Levinson, Douglas F., Potash, James B., Weissman, Myrna M., Shi, Jianxin, Lewis, Glyn, Penninx, Brenda W. J. H., Boomsma, Dorret I., Hamilton, Steven P., Sibille, Etienne, Hariri, Ahmad R., Nikolova, Yuliya S. and Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2021). Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk. Neuropsychopharmacology, 46 (13), 2304-2311. doi: 10.1038/s41386-021-01189-x

Polygenic risk scores derived from varying definitions of depression and risk of depression

Mitchell, Brittany L., Thorp, Jackson G., Wu, Yeda, Campos, Adrian I., Nyholt, Dale R., Gordon, Scott D., Whiteman, David C., Olsen, Catherine M., Hickie, Ian B., Martin, Nicholas G., Medland, Sarah E., Wray, Naomi R. and Byrne, Enda M. (2021). Polygenic risk scores derived from varying definitions of depression and risk of depression. JAMA Psychiatry, 78 (10), 1152-1160. doi: 10.1001/jamapsychiatry.2021.1988

Genetic risk for chronic pain is associated with lower antidepressant effectiveness: converging evidence for a depression subtype

Campos, Adrián I., Ngo, Trung Thanh, Medland, Sarah E., Wray, Naomi R., Hickie, Ian B., Byrne, Enda M., Martin, Nicholas G. and Rentería, Miguel E. (2021). Genetic risk for chronic pain is associated with lower antidepressant effectiveness: converging evidence for a depression subtype. Australian and New Zealand Journal of Psychiatry, 56 (9) ARTN 00048674211031491, 1-10. doi: 10.1177/00048674211031491

Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits

Martin, Joanna, Khramtsova, Ekaterina A., Goleva, Slavina B., Blokland, Gabriëlla A.M., Traglia, Michela, Walters, Raymond K., Hübel, Christopher, Coleman, Jonathan R.I., Breen, Gerome, Børglum, Anders D., Demontis, Ditte, Grove, Jakob, Werge, Thomas, Bralten, Janita, Bulik, Cynthia M., Lee, Phil H., Mathews, Carol A., Peterson, Roseann E., Winham, Stacey J., Wray, Naomi, Edenberg, Howard J., Guo, Wei, Yao, Yin, Neale, Benjamin M., Faraone, Stephen V., Petryshen, Tracey L., Weiss, Lauren A., Duncan, Laramie E., Goldstein, Jill M. ... Stahl, Eli (2021). Examining sex-differentiated genetic effects across neuropsychiatric and behavioral traits. Biological Psychiatry, 89 (12), 1127-1137. doi: 10.1016/j.biopsych.2020.12.024

Erratum: Alzheimer's disease genetic risk and sleep phenotypes in healthy young men: Association with more slow waves and daytime sleepiness (SLEEP DOI: 10.1093/sleep/zsaa137)

Muto, Vincenzo, Koshmanova, Ekaterina, Ghaemmaghami, Pouya, Jaspar, Mathieu, Meyer, Christelle, Elansary, Mahmoud, Van Egroo, Maxime, Chylinski, Daphne, Berthomier, Christian, Brandewinder, Marie, Mouraux, Charlotte, Schmidt, Christina, Hammad, Gregory, Coppieters, Wouter, Ahariz, Naima, Degueldre, Christian, Luxen, Andre, Salmon, Eric, Phillips, Christophe, Archer, Simon N, Yengo, Loic, Byrne, Enda, Collette, Fabienne, Georges, Michel, Dijk, Derk-Jan, Maquet, Pierre, Visscher, Peter M and Vandewalle, Gilles (2021). Erratum: Alzheimer's disease genetic risk and sleep phenotypes in healthy young men: Association with more slow waves and daytime sleepiness (SLEEP DOI: 10.1093/sleep/zsaa137). Sleep, 44 (5) zsaa137. doi: 10.1093/sleep/zsab079

Symptom-level modelling unravels the shared genetic architecture of anxiety and depression

Thorp, Jackson G., Campos, Adrian I., Grotzinger, Andrew D., Gerring, Zachary F., An, Jiyuan, Ong, Jue-Sheng, Wang, Wei, Shringarpure, Suyash, Byrne, Enda M., MacGregor, Stuart, Martin, Nicholas G., Medland, Sarah E., Middeldorp, Christel M. and Derks, Eske M. (2021). Symptom-level modelling unravels the shared genetic architecture of anxiety and depression. Nature Human Behaviour, 5 (10), 1432-1442. doi: 10.1038/s41562-021-01094-9

Comorbid chronic pain and depression: shared risk factors and differential antidepressant effectiveness

Roughan, William H., Campos, Adrián I., García-Marín, Luis M., Cuéllar-Partida, Gabriel, Lupton, Michelle K., Hickie, Ian B., Medland, Sarah E., Wray, Naomi R., Byrne, Enda M., Ngo, Trung Thanh, Martin, Nicholas G. and Rentería, Miguel E. (2021). Comorbid chronic pain and depression: shared risk factors and differential antidepressant effectiveness. Frontiers in Psychiatry, 12 643609, 1-13. doi: 10.3389/fpsyt.2021.643609

Can network analysis of self-reported psychopathology shed light on the core phenomenology of bipolar disorders in adolescents and young adults?

Scott, Jan, Crouse, Jacob J., Ho, Nicholas, Carpenter, Joanne, Martin, Nicholas, Medland, Sarah, Parker, Richard, Byrne, Enda, Couvy-Duchesne, Baptiste, Mitchell, Brittany, Merikangas, Kathleen, Gillespie, Nathan A. and Hickie, Ian (2021). Can network analysis of self-reported psychopathology shed light on the core phenomenology of bipolar disorders in adolescents and young adults?. Bipolar Disorders, 23 (6), 584-594. doi: 10.1111/bdi.13067

GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression

Wu, Yeda, Murray, Graham K., Byrne, Enda M., Sidorenko, Julia, Visscher, Peter M. and Wray, Naomi R. (2021). GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression. Nature Communications, 12 (1) 1146, 1-17. doi: 10.1038/s41467-021-21280-7

A meta-analysis of the relationship between subjective sleep and depressive symptoms in adolescence

O’Callaghan, Victoria S., Couvy-Duchesne, Baptiste, Strike, Lachlan T., McMahon, Katie L., Byrne, Enda M. and Wright, Margaret J. (2021). A meta-analysis of the relationship between subjective sleep and depressive symptoms in adolescence. Sleep Medicine, 79, 134-144. doi: 10.1016/j.sleep.2021.01.011

Schizophrenia polygenic risk scores in youth mental health: preliminary associations with diagnosis, clinical stage and functioning

Crouse, Jacob J., Carpenter, Joanne S., Iorfino, Frank, Lin, Tian, Ho, Nicholas, Byrne, Enda M., Henders, Anjali K., Wallace, Leanne, Hermens, Daniel F., Scott, Elizabeth M., Wray, Naomi R. and Hickie, Ian B. (2021). Schizophrenia polygenic risk scores in youth mental health: preliminary associations with diagnosis, clinical stage and functioning. BJPsych Open, 7 (2) e58, e58. doi: 10.1192/bjo.2021.14

Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders

Blokland, Gabriëlla A.M., Grove, Jakob, Chen, Chia-Yen, Cotsapas, Chris, Tobet, Stuart, Handa, Robert, Ripke, Stephan, Neale, Benjamin M., Corvin, Aiden, Walters, James T.R., Farh, Kai-How, Holmans, Peter A., Lee, Phil, Bulik-Sullivan, Brendan, Collier, David A., Huang, Hailiang, Pers, Tune H., Agartz, Ingrid, Agerbo, Esben, Albus, Margot, Alexander, Madeline, Amin, Farooq, Bacanu, Silviu A., Begemann, Martin, Belliveau, Richard A., Bene, Judit, Bergen, Sarah E., Bevilacqua, Elizabeth, Bigdeli, Tim B. ... iPSYCH (2021). Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders. Biological Psychiatry, 91 (1), 102-117. doi: 10.1016/j.biopsych.2021.02.972

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

Shen, Xueyi, Howard, David M., Adams, Mark J., Hill, W. David, Clarke, Toni-Kim, Adams, Mark J., Clarke, Toni-Kim, McIntosh, Andrew M., Deary, Ian J., Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Agerbo, Esben, Air, Tracy M., Andlauer, Till F. M., Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B., Binder, Elisabeth B., Bryois, Julien, Buttenschøn, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane Hvarregaard ... McIntosh, Andrew M. (2020). A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank. Nature Communications, 11 (1) 2301. doi: 10.1038/s41467-020-16022-0

Short communication: Self-reported sleep-wake disturbances preceding onset of full-threshold mood and/or psychotic syndromes in community residing adolescents and young adults

Scott, Jan, Byrne, Enda, Medland, Sarah and Hickie, Ian (2020). Short communication: Self-reported sleep-wake disturbances preceding onset of full-threshold mood and/or psychotic syndromes in community residing adolescents and young adults. Journal of Affective Disorders, 277, 592-595. doi: 10.1016/j.jad.2020.08.083

Refining attention-deficit/hyperactivity disorder and autism spectrum disorder genetic loci by integrating summary data from genome-wide association, gene expression and DNA methylation studies

Hammerschlag, Anke R., Byrne, Enda M., Bartels, Meike, Wray, Naomi R., Middeldorp, Christel M., eQTLGen Consortium, BIOS Consortium, Ahsan, Habibul, Alves, Isabel, Andiappan, Anand, Arindrarto, Wibowo, Awadalla, Philip, Battle, Alexis, Beutner, Frank, Bonder, Marc Jan, Boomsma, Dorret I., Christiansen, Mark, Claringbould, Annique, Deelen, Patrick, Esko, Tõnu, Favé, Marie-Julie, Franke, Lude, Frayling, Timothy, Gharib, Sina A., Gibson, Gregory, Heijmans, Bastiaan T., Hemani, Gibran, Jansen, Rick, Kähönen, Mika, Kalnapenkis, Anette ... Agbessi, Mawussé (2020). Refining attention-deficit/hyperactivity disorder and autism spectrum disorder genetic loci by integrating summary data from genome-wide association, gene expression and DNA methylation studies. Biological Psychiatry, 88 (6), 470-479. doi: 10.1016/j.biopsych.2020.05.002

Genetic control of temperament traits across species: association of autism spectrum disorder risk genes with cattle temperament

Costilla, Roy, Kemper, Kathryn E., Byrne, Enda M., Porto-Neto, Laercio R., Carvalheiro, Roberto, Purfield, Deirdre C., Doyle, Jennifer L., Berry, Donagh P., Moore, Stephen S., Wray, Naomi R. and Hayes, Ben J. (2020). Genetic control of temperament traits across species: association of autism spectrum disorder risk genes with cattle temperament. Genetics Selection Evolution, 52 (1) 51, 51. doi: 10.1186/s12711-020-00569-z

Cohort profile: the Australian genetics of depression study

Byrne, Enda M., Kirk, Katherine M., Medland, Sarah E., McGrath, John J., Colodro-Conde, Lucia, Parker, Richard, Cross, Simone, Sullivan, Lenore, Statham, Dixie J., Levinson, Douglas F., Licinio, Julio, Wray, Naomi R, Hickie, Ian B. and Martin, Nicholas G. (2020). Cohort profile: the Australian genetics of depression study. BMJ Open, 10 (5) e032580, e032580. doi: 10.1136/bmjopen-2019-032580

Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders

Byrne, Enda M., Zhu, Zhihong, Qi, Ting, Skene, Nathan G., Bryois, Julien, Pardinas, Antonio F., Stahl, Eli, Bipolar Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Rietschel, Marcella, Smoller, Jordan W., Owen, Michael J., Walters, James T. R., O’Donovan, Michael C., McGrath, John G., Hjerling-Leffler, Jens, Sullivan, Patrick F., Goddard, Michael E., Visscher, Peter M., Yang, Jian and Wray, Naomi R. (2020). Conditional GWAS analysis to identify disorder-specific SNPs for psychiatric disorders. Molecular Psychiatry, 26 (6), 2070-2081. doi: 10.1038/s41380-020-0705-9

Minimal phenotyping yields genome-wide association signals of low specificity for major depression

Cai, Na, Revez, Joana A., Adams, Mark J., Andlauer, Till F. M., Breen, Gerome, Byrne, Enda M., Clarke, Toni-Kim, Forstner, Andreas J., Grabe, Hans J., Hamilton, Steven P., Levinson, Douglas F., Lewis, Cathryn M., Lewis, Glyn, Martin, Nicholas G., Milaneschi, Yuri, Mors, Ole, Müller-Myhsok, Bertram, Penninx, Brenda W. J. H., Perlis, Roy H., Pistis, Giorgio, Potash, James B., Preisig, Martin, Shi, Jianxin, Smoller, Jordan W., Streit, Fabien, Tiemeier, Henning, Uher, Rudolf, Van der Auwera, Sandra, Viktorin, Alexander ... Flint, Jonathan (2020). Minimal phenotyping yields genome-wide association signals of low specificity for major depression. Nature Genetics, 52 (4), 437-447. doi: 10.1038/s41588-020-0594-5

Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

Amare, Azmeraw T., Schubert, Klaus Oliver, Hou, Liping, Clark, Scott R., Papiol, Sergi, Cearns, Micah, Heilbronner, Urs, Degenhardt, Franziska, Tekola-Ayele, Fasil, Hsu, Yi-Hsiang, Shekhtman, Tatyana, Adli, Mazda, Akula, Nirmala, Akiyama, Kazufumi, Ardau, Raffaella, Arias, Bárbara, Aubry, Jean-Michel, Backlund, Lena, Bhattacharjee, Abesh Kumar, Bellivier, Frank, Benabarre, Antonio, Bengesser, Susanne, Biernacka, Joanna M., Birner, Armin, Brichant-Petitjean, Clara, Cervantes, Pablo, Chen, Hsi-Chung, Chillotti, Caterina, Cichon, Sven ... Baune, Bernhard T. (2020). Association of polygenic score for major depression with response to lithium in patients with bipolar disorder. Molecular Psychiatry, 26 (6), 2457-2470. doi: 10.1038/s41380-020-0689-5

Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank

Campos, Adrián I., García-Marín, Luis M., Byrne, Enda M., Martin, Nicholas G., Cuéllar-Partida, Gabriel and Rentería, Miguel E. (2020). Insights into the aetiology of snoring from observational and genetic investigations in the UK Biobank. Nature Communications, 11 (1) 817, 817. doi: 10.1038/s41467-020-14625-1

Genome-wide association study of dietary intake in the UK biobank study and its associations with schizophrenia and other traits

Niarchou, Maria, Byrne, Enda M., Trzaskowski, Maciej, Sidorenko, Julia, Kemper, Kathryn E., McGrath, John J., O’ Donovan, Michael C., Owen, Michael J. and Wray, Naomi R. (2020). Genome-wide association study of dietary intake in the UK biobank study and its associations with schizophrenia and other traits. Translational Psychiatry, 10 (1) 51, 1-11. doi: 10.1038/s41398-020-0688-y

Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Coleman, Jonathan R. I., Peyrot, Wouter J., Purves, Kirstin L., Davis, Katrina A. S., Rayner, Christopher, Choi, Shing Wan, Hübel, Christopher, Gaspar, Héléna A., Kan, Carol, Van der Auwera, Sandra, Adams, Mark James, Lyall, Donald M., Choi, Karmel W., Dunn, Erin C., Vassos, Evangelos, Danese, Andrea, Maughan, Barbara, Grabe, Hans J., Lewis, Cathryn M., O’Reilly, Paul F., McIntosh, Andrew M., Smith, Daniel J., Wray, Naomi R., Hotopf, Matthew, Eley, Thalia C., Breen, Gerome, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Trzaskowski, Maciej, Byrne, Enda M. ... Middeldorp, Christel M. (2020). Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. Molecular Psychiatry, 25 (7), 1430-1446. doi: 10.1038/s41380-019-0546-6

Nick Martin and the genetics of depression: sample size, sample size, sample size

Byrne, Enda M., Henders, Anjali K., Hickie, Ian B., Middeldorp, Christel M. and Wray, Naomi R. (2020). Nick Martin and the genetics of depression: sample size, sample size, sample size. Twin Research and Human Genetics, 23 (2), 1-3. doi: 10.1017/thg.2020.13

Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders

Lee, Phil H., Anttila, Verneri, Won, Hyejung, Feng, Yen-Chen A., Rosenthal, Jacob, Zhu, Zhaozhong, Tucker-Drob, Elliot M., Nivard, Michel G., Grotzinger, Andrew D., Posthuma, Danielle, Wang, Meg M.-J., Yu, Dongmei, Stahl, Eli A., Walters, Raymond K., Anney, Richard J.L., Duncan, Laramie E., Ge, Tian, Adolfsson, Rolf, Banaschewski, Tobias, Belangero, Sintia, Cook, Edwin H., Coppola, Giovanni, Derks, Eske M., Hoekstra, Pieter J., Kaprio, Jaakko, Keski-Rahkonen, Anna, Kirov, George, Kranzler, Henry R., Luykx, Jurjen J. ... Smoller, Jordan W. (2019). Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders. Cell, 179 (7), 1469-1482.e11. doi: 10.1016/j.cell.2019.11.020

Shared and specific genetic risk factors for lifetime major depression, depressive symptoms and neuroticism in three population-based twin samples

Kendler, Kenneth S., Gardner, Charles O., Neale, Michael C., Aggen, Steve, Heath, Andrew, Colodro-Conde, Lucía, Couvyduchesne, Baptiste, Byrne, Enda M., Martin, Nicholas G. and Gillespie, Nathan A. (2019). Shared and specific genetic risk factors for lifetime major depression, depressive symptoms and neuroticism in three population-based twin samples. Psychological Medicine, 49 (16), 2745-2753. doi: 10.1017/S003329171800377X

Genetic risk scores for major psychiatric disorders and the risk of postpartum psychiatric disorders

Bauer, Anna E., Liu, Xiaoqin, Byrne, Enda M., Sullivan, Patrick F., Wray, Naomi R., Agerbo, Esben, Nyegaard, Mette, Grove, Jakob, Musliner, Katherine L., Ingstrup, Katja G., Johannsen, Benedicte M. W., Mægbæk, Merete L., Wang, Yunpeng, Nordentoft, Merete, Mors, Ole, Børglum, Anders D., Werge, Thomas, Hougaard, David M., Mortensen, Preben Bo, Munk-Olsen, Trine and Meltzer-Brody, Samantha (2019). Genetic risk scores for major psychiatric disorders and the risk of postpartum psychiatric disorders. Translational Psychiatry, 9 (1) 288, 288. doi: 10.1038/s41398-019-0629-9

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Andlauer, Till F. M., Guzman-Parra, Jose, Streit, Fabian, Strohmaier, Jana, González, Maria José, Gil Flores, Susana, Cabaleiro Fabeiro, Francisco J., del Río Noriega, Francisco, Perez, Fermin Perez, Haro González, Jesus, Orozco Diaz, Guillermo, de Diego-Otero, Yolanda, Moreno-Küstner, Berta, Auburger, Georg, Degenhardt, Franziska, Heilmann-Heimbach, Stefanie, Herms, Stefan, Hoffmann, Per, Frank, Josef, Foo, Jerome C., Treutlein, Jens, Witt, Stephanie H., Cichon, Sven, Kogevinas, Manolis, Stahl, Eli A, Breen, Gerome, Forstner, Andreas J, McQuillin, Andrew, Ripke, Stephan ... Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2019). Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders. Molecular Psychiatry, 26 (4), 1286-1298. doi: 10.1038/s41380-019-0558-2

The genetics of the mood disorder spectrum: Genome-wide association analyses of more than 185,000 cases and 439,000 controls

Coleman, Jonathan R.I., Gaspar, Héléna A., Bryois, Julien, Byrne, Enda M., Forstner, Andreas J., Holmans, Peter A., de Leeuw, Christiaan A., Mattheisen, Manuel, McQuillin, Andrew, Whitehead Pavlides, Jennifer M., Pers, Tune H., Ripke, Stephan, Stahl, Eli A., Steinberg, Stacy, Trubetskoy, Vassily, Trzaskowski, Maciej, Wang, Yunpeng, Abbott, Liam, Abdellaoui, Abdel, Adams, Mark J., Adolfsson, Annelie Nordin, Agerbo, Esben, Akil, Huda, Albani, Diego, Alliey-Rodriguez, Ney, Als, Thomas D., Andlauer, Till F.M., Anjorin, Adebayo, Antilla, Verneri ... Breen, Gerome (2019). The genetics of the mood disorder spectrum: Genome-wide association analyses of more than 185,000 cases and 439,000 controls. Biological Psychiatry, 88 (2), 169-184. doi: 10.1016/j.biopsych.2019.10.015

The relationship between insomnia and complex diseases-insights from genetic data

Byrne, Enda M. (2019). The relationship between insomnia and complex diseases-insights from genetic data. Genome Medicine, 11 (1) 57, 57. doi: 10.1186/s13073-019-0668-0

Classical human leukocyte antigen alleles and C4 haplotypes are not significantly associated With depression

Glanville, Kylie P., Coleman, Jonathan R. I., Hanscombe, Ken B., Euesden, Jack, Choi, Shing Wan, Purves, Kirstin L., Breen, Gerome, Air, Tracy M., Andlauer, Till F. M., Baune, Bernhard T., Binder, Elisabeth B., Blackwood, Douglas H. R., Boomsma, Dorret I., Buttenschøn, Henriette N., Colodro-Conde, Lucía, Dannlowski, Udo, Direk, Nese, Dunn, Erin C., Forstner, Andreas J., de Geus, Eco J. C., Grabe, Hans J., Hamilton, Steven P., Jones, Ian, Jones, Lisa A., Knowles, James A., Kutalik, Zoltán, Levinson, Douglas F., Lewis, Glyn, Lind, Penelope A. ... Børglum, Anders D. (2019). Classical human leukocyte antigen alleles and C4 haplotypes are not significantly associated With depression. Biological Psychiatry, 87 (5), 419-430. doi: 10.1016/j.biopsych.2019.06.031

GWAS of suicide attempt in psychiatric disorders and association with major depression polygenic risk scores

Mullins, Niamh, Bigdeli, Tim B., Børglum, Anders D., Coleman, Jonathan R.I., Demontis, Ditte, Mehta, Divya, Power, Robert A., Ripke, Stephan, Stahl, Eli A., Starnawska, Anna, Anjorin, Adebayo, Corvin, Aiden, Sanders, Alan R., Forstner, Andreas J., Reif, Andreas, Koller, Anna C., Tkowska, Beata Swia, Baune, Bernhard T., Müller-Myhsok, Bertram, Penninx, Brenda W.J.H., Pato, Carlos, Zai, Clement, Rujescu, Dan, Hougaard, David M., Quested, Digby, Levinson, Douglas F., Binder, Elisabeth B., Byrne, Enda M., Agerbo, Esben ... Lewis, Cathryn M. (2019). GWAS of suicide attempt in psychiatric disorders and association with major depression polygenic risk scores. American Journal of Psychiatry, 176 (8), 651-660. doi: 10.1176/appi.ajp.2019.18080957

Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

Pardiñas, Antonio F., Holmans, Peter, Pocklington, Andrew J., Escott-Price, Valentina, Ripke, Stephan, Carrera, Noa, Legge, Sophie E., Bishop, Sophie, Cameron, Darren, Hamshere, Marian L., Han, Jun, Hubbard, Leon, Lynham, Amy, Mantripragada, Kiran, Rees, Elliott, MacCabe, James H., McCarroll, Steven A., Baune, Bernhard T., Breen, Gerome, Byrne, Enda M., Dannlowski, Udo, Eley, Thalia C., Hayward, Caroline, Martin, Nicholas G., McIntosh, Andrew M., Plomin, Robert, Porteous, David J., Wray, Naomi R., Caballero, Armando ... Walters, James T. R. (2019). Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nature Genetics, 51 (7), 1193-1193. doi: 10.1038/s41588-019-0450-7

Genome-wide association study identifies 30 loci associated with bipolar disorder

Stahl, Eli A., Breen, Gerome, Forstner, Andreas J., McQuillin, Andrew, Ripke, Stephan, Trubetskoy, Vassily, Mattheisen, Manuel, Wang, Yunpeng, Coleman, Jonathan R. I., Gaspar, Héléna A., de Leeuw, Christiaan A., Steinberg, Stacy, Pavlides, Jennifer M. Whitehead, Trzaskowski, Maciej, Byrne, Enda M., Pers, Tune H., Holmans, Peter A., Richards, Alexander L., Abbott, Liam, Agerbo, Esben, Akil, Huda, Albani, Diego, Alliey-Rodriguez, Ney, Als, Thomas D., Anjorin, Adebayo, Antilla, Verneri, Awasthi, Swapnil, Badner, Judith A., Bækvad-Hansen, Marie ... Sklar, Pamela (2019). Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature Genetics, 51 (5), 793-803. doi: 10.1038/s41588-019-0397-8

Genome-wide association study of medication-use and associated disease in the UK Biobank

Wu, Yeda, Byrne, Enda M., Zheng, Zhili, Kemper, Kathryn E., Yengo, Loic, Mallett, Andrew J., Yang, Jian, Visscher, Peter M. and Wray, Naomi R. (2019). Genome-wide association study of medication-use and associated disease in the UK Biobank. Nature Communications, 10 (1) 1891, 1891. doi: 10.1038/s41467-019-09572-5

Assessment of bidirectional relationships between physical activity and depression among adults A 2-Sample mendelian randomization study

Choi, Karmel W., Chen, Chia-Yen, Stein, Murray B., Klimentidis, Yann C., Wang, Min-Jung, Koenen, Karestan C., Smoller, Jordan W., Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, TracyM., Andlauer, Till F. M., Bacanu, Silviu-Alin, Baekvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H. R., Bryois, Julien, Buttenschon, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Hvarregaard, Jane ... Sullivan, Patrick F. (2019). Assessment of bidirectional relationships between physical activity and depression among adults A 2-Sample mendelian randomization study. JAMA Psychiatry, 76 (4), 399-408. doi: 10.1001/jamapsychiatry.2018.4175

Identification of common genetic risk variants for autism spectrum disorder

Grove, Jakob, Ripke, Stephan, Als, Thomas D., Mattheisen, Manuel, Walters, Raymond K., Won, Hyejung, Pallesen, Jonatan, Agerbo, Esben, Andreassen, Ole A., Anney, Richard, Awashti, Swapnil, Belliveau, Rich, Bettella, Francesco, Buxbaum, Joseph D., Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Marie, Cerrato, Felecia, Chambert, Kimberly, Christensen, Jane H., Churchhouse, Claire, Dellenvall, Karin, Demontis, Ditte, De Rubeis, Silvia, Devlin, Bernie, Djurovic, Srdjan, Dumont, Ashley L., Goldstein, Jacqueline I., Hansen, Christine S., Hauberg, Mads Engel ... Børglum, Anders D. (2019). Identification of common genetic risk variants for autism spectrum disorder. Nature Genetics, 51 (3), 431-444. doi: 10.1038/s41588-019-0344-8

Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland

Arnau-Soler, Aleix, Macdonald-Dunlop, Erin, Adams, Mark J., Clarke, Toni-Kim, MacIntyre, Donald J., Milburn, Keith, Navrady, Lauren, Hayward, Caroline, McIntosh, Andrew M., Thomson, Pippa A., Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Agerbo, Esben, Air, Tracy M., Andlauer, Till F. M., Bacanu, Silviu-Alin, Baekvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H. R., Bryois, Julien, Buttenscon, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na ... Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2019). Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland. Translational Psychiatry, 9 (1) 14. doi: 10.1038/s41398-018-0360-y

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

Howard, David M., Adams, Mark J., Clarke, Toni-Kim, Hafferty, Jonathan D., Gibson, Jude, Shirali, Masoud, Coleman, Jonathan R. I., Hagenaars, Saskia P., Ward, Joey, Wigmore, Eleanor M., Alloza, Clara, Shen, Xueyi, Barbu, Miruna C., Xu, Eileen Y., Whalley, Heather C., Marioni, Riccardo E., Porteous, David J., Davies, Gail, Deary, Ian J., Hemani, Gibran, Berger, Klaus, Teismann, Henning, Rawal, Rajesh, Arolt, Volker, Baune, Bernhard T., Dannlowski, Udo, Domschke, Katharina, Tian, Chao, Hinds, David A. ... McIntosh, Andrew M. (2019). Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions. Nature Neuroscience, 22 (3), 343-352. doi: 10.1038/s41593-018-0326-7

Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms

Jones, Samuel E., Lane, Jacqueline M., Wood, Andrew R., van Hees, Vincent T., Tyrrell, Jessica, Beaumont, Robin N., Jeffries, Aaron R., Dashti, Hassan S., Hillsdon, Melvyn, Ruth, Katherine S., Tuke, Marcus A., Yaghootkar, Hanieh, Sharp, Seth A., Jie, Yingjie, Thompson, William D., Harrison, Jamie W., Dawes, Amy, Byrne, Enda M., Tiemeier, Henning, Allebrandt, Karla V., Bowden, Jack, Ray, David W., Freathy, Rachel M., Murray, Anna, Mazzotti, Diego R., Gehrman, Philip R., Lawlor, Debbie A., Frayling, Timothy M., Rutter, Martin K. ... Weedon, Michael N. (2019). Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms. Nature Communications, 10 (1) 343, 343. doi: 10.1038/s41467-018-08259-7

Evidence for increased genetic risk load for major depression in patients assigned to electroconvulsive therapy

Foo, Jerome C., Streit, Fabian, Frank, Josef, Witt, Stephanie H., Treutlein, Jens, Baune, Bernhard T., Moebus, Susanne, Joeckel, Karl-Heinz, Forstner, Andreas J., Noethen, Markus M., Rietschel, Marcella, Sartorius, Alexander, Kranaster, Laura, Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till F. M., Bacanu, Silviu-Alin, Baekvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H. R. ... Sullivan, Patrick F. (2019). Evidence for increased genetic risk load for major depression in patients assigned to electroconvulsive therapy. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 180 (1), 35-45. doi: 10.1002/ajmg.b.32700

Sleep disorders and risk of incident depression: a population case-control study

Byrne, Enda M., Timmerman, Allan, Wray, Naomi R. and Agerbo, Esben (2019). Sleep disorders and risk of incident depression: a population case-control study. Twin Research and Human Genetics, 22 (03), 140-146. doi: 10.1017/thg.2019.22

Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling

Elia, Josephine, Ungal, Grace, Kao, Charlly, Ambrosini, Alexander, De Jesus-Rosario, Nilsa, Larsen, Lene, Chiavacci, Rosetta, Wang, Tiancheng, Kurian, Christine, Titchen, Kanani, Sykes, Brian, Hwang, Sharon, Kumar, Bhumi, Potts, Jacqueline, Davis, Joshua, Malatack, Jeffrey, Slattery, Emma, Moorthy, Ganesh, Zuppa, Athena, Weller, Andrew, Byrne, Enda, Li, Yun R., Kraft, Walter K. and Hakonarson, Hakon (2018). Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling. Nature Communications, 9 (1) 4, 1-9. doi: 10.1038/s41467-017-02244-2

Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder

Arnau-Soler, Aleix, Adams, Mark J., Hayward, Caroline, Thomson, Pippa A., Porteous, David, Campbell, Archie, Smith, Blair H., Black, Corri, Padmanabhan, Sandosh, McIntosh, Andrew, Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Agerbo, Esben, Air, Tracy M., Andlauer, Till F.M., Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T.F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H.R., Bryois, Julien, Buttenschøn, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na ... Sullivan, Patrick F. (2018). Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder. PLoS ONE, 13 (12) e0209160, e0209160. doi: 10.1371/journal.pone.0209160

PPD ACT: an app-based genetic study of postpartum depression

Guintivano, Jerry, Krohn, Holly, Lewis, Carol, Byrne, Enda M., Henders, Anjali K., Ploner, Alexander, Kirk, Katherine, Martin, Nicholas G., Milgrom, Jeannette, Wray, Naomi R., Sullivan, Patrick F. and Meltzer-Brody, Samantha (2018). PPD ACT: an app-based genetic study of postpartum depression. Translational Psychiatry, 8 (1) 260, 260. doi: 10.1038/s41398-018-0305-5

Is schizophrenia a risk factor for breast cancer?—evidence from genetic data

Byrne, Enda M., Ferreira, Manuel A.R., Xue, Angli, Lindström, Sara, Jiang, Xia, Yang, Jian, Easton, Douglas F., Wray, Naomi R. and Chenevix-Trench, Georgia (2018). Is schizophrenia a risk factor for breast cancer?—evidence from genetic data. Schizophrenia Bulletin, 45 (6), 1251-1256. doi: 10.1093/schbul/sby162

Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

de Jong, Simone, Abdalla Diniz, Mateus Jose, Saloma, Andiara, Gadelha, Ary, Santoro, Marcos L., Ota, Vanessa K., Noto, Cristiano, Curtis, Charlesg, Newhouse, Stephen J., Patel, Hamel, Hall, Lynsey S., O'Reilly, Paul F., Belangero, Sintia, Bressan, Rodrigo A., Breen, Gerome, Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till F. M., Bacanu, Silviu-Alin, Baekvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B. ... Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium (2018). Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder. Communications Biology, 1 (163) 163. doi: 10.1038/s42003-018-0155-y

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till M. F., Bacanu, Silviu-Alin, Baekvad-Hansen, Marie, Beekman, Aartjan F. T., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas R. H., Bryois, Julien, Buttenschon, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane Hvarregaard, Clarke, Toni-Kim, Coleman, Jonathan I. R., Colodro-Conde, Lucia, Couvy-Duchesne, Baptiste, Craddock, Nick, Crawford, Gregory E., Crowley, Cheynna A. ... Sullivan, Patrick F. (2018). Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nature Genetics, 50 (5), 668-+. doi: 10.1038/s41588-018-0090-3

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection

Pardiñas, Antonio F, Holmans, Peter, Pocklington, Andrew J, Escott-Price, Valentina, Ripke, Stephan, Carrera, Noa, Legge, Sophie E, Bishop, Sophie, Cameron, Darren, Hamshere, Marian L, Han, Jun, Hubbard, Leon, Lynham, Amy, Mantripragada, Kiran, Rees, Elliott, MacCabe, James H, McCarroll, Steven A, Baune, Bernhard T, Breen, Gerome, Byrne, Enda M., Dannlowski, Udo, Eley, Thalia C, Hayward, Caroline, Martin, Nicholas G., McIntosh, Andrew M, Plomin, Robert, Porteous, David J, Wray, Naomi R, Caballero, Armando ... CRESTAR Consortium (2018). Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nature Genetics, 50 (3), 381-389. doi: 10.1038/s41588-018-0059-2

Association of whole-genome and NETRIN1 signaling pathway–derived polygenic risk scores for major depressive disorder and white matter microstructure in the UK Biobank

Barbu, Miruna C., Zeng, Yanni, Shen, Xueyi, Cox, Simon R., Clarke, Toni-Kim, Gibson, Jude, Adams, Mark J., Johnstone, Mandy, Haley, Chris S., Lawrie, Stephen M., Deary, Ian J., Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till F.M., Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T.F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H.R., Bryois, Julien ... Whalley, Heather C. (2018). Association of whole-genome and NETRIN1 signaling pathway–derived polygenic risk scores for major depressive disorder and white matter microstructure in the UK Biobank. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 4 (1), 91-100. doi: 10.1016/j.bpsc.2018.07.006

Genome-wide gene-environment interaction in depression: a systematic evaluation of candidate genes: the childhood trauma working-group of PGC-MDD

Van der Auwera, Sandra, Peyrot, Wouter J., Milaneschi, Yuri, Hertel, Johannes, Baune, Bernhard, Breen, Gerome, Byrne, Enda, Dunn, Erin C, Fisher, Helen, Homuth, Georg, Levinson, Douglas, Lewis, Cathryn, Mills, Natalie, Mullins, Niamh, Nauck, Matthias, Pistis, Giorgio, Preisig, Martin, Rietschel, Marcella, Ripke, Stephan, Sullivan, Patrick, Teumer, Alexander, Völzke, Henry, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Boomsma, Dorret I., Wray, Naomi R., Penninx, Brenda and Grabe, Hans (2018). Genome-wide gene-environment interaction in depression: a systematic evaluation of candidate genes: the childhood trauma working-group of PGC-MDD. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 177 (1), 40-49. doi: 10.1002/ajmg.b.32593

Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

Rietschel, Liz, Streit, Fabian, Zhu, Gu, McAloney, Kerrie, Frank, Josef, Couvy-Duchesne, Baptiste, Witt, Stephanie H., Binz, Tina M., Bolton, Jennifer L., Hayward, Caroline, Direk, Nese, Anderson, Anna, Huffman, Jennifer, Wilson, James F., Campbell, Harry, Rudan, Igor, Wright, Alan, Hastie, Nicholas, Wild, Sarah H., Velders, Fleur P., Hofman, Albert, Uitterlinden, Andre G., Lahti, Jari, Räikkönen, Katri, Kajantie, Eero, Widen, Elisabeth, Palotie, Aarno, Eriksson, Johan G., Kaakinen, Marika ... Rietschel, Marcella (2017). Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes. Scientific Reports, 7 (1) 15351, 15351. doi: 10.1038/s41598-017-11852-3

Inference in Psychiatry via 2-Sample Mendelian Randomization-From Association to Causal Pathway?

Byrne, Enda M, Yang, Jian and Wray, Naomi R (2017). Inference in Psychiatry via 2-Sample Mendelian Randomization-From Association to Causal Pathway?. JAMA psychiatry, 74 (12), 1191-1192. doi: 10.1001/jamapsychiatry.2017.3162

Investigating the relationship between iron and depression

Mills, Natalie T., Maier, Robert, Whitfield, John B., Wright, Margaret J., Colodro-Conde, Lucia, Byrne, Enda M., Scott, James G., Byrne, Gerard J., Hansell, Narelle K., Vinkhuyzen, Anna A. E., CouvyDuchesne, Baptiste, Montgomery, Grant W., Henders, Anjali K., Martin, Nicholas G., Wray, Naomi R. and Benyamin, Beben (2017). Investigating the relationship between iron and depression. Journal of Psychiatric Research, 94, 148-155. doi: 10.1016/j.jpsychires.2017.07.006

Does childhood trauma moderate polygenic risk for depression? A meta-analysis of 5,765 subjects from the Psychiatric Genomics Consortium

Peyrot, Wouter J., Van der Auwera, Sandra, Milaneschi, Yuri, Dolan, Conor V., Madden, Pamela A. F., Sullivan, Patrick F., Strohmaier, Jana, Ripke, Stephan, Rietschel, Marcella, Nivard, Michel G., Mullins, Niamh, Montgomery, Grant W., Henders, Anjali K., Heat, Andrew C., Fisher, Helen L., Dunn, Erin C., Byrne, Enda M., Air, Tracy A., Baune, Bernhard T., Breen, Gerome, Levinson, Douglas F., Lewis, Cathryn M., Martin, Nick G., Nelson, Elliot N., Boomsma, Dorret I., Grabe, Hans J., Wray, Naomi R. and Penninx, Brenda W. J. H. (2017). Does childhood trauma moderate polygenic risk for depression? A meta-analysis of 5,765 subjects from the Psychiatric Genomics Consortium. Biological Psychiatry, 84 (2), 138-147. doi: 10.1016/j.biopsych.2017.09.009

A direct test of the diathesis–stress model for depression

Colodro-Conde, L., Couvy-Duchesne, B., Zhu, G., Coventry, W. L., Byrne, E. M., Gordon, S., Wright, M. J., Montgomery, G. W., Madden, P. A. F., Ripke, S., Eaves, L. J., Heath, A. C., Wray, N. R., Medland, S. E. and Martin, N. G. (2017). A direct test of the diathesis–stress model for depression. Molecular Psychiatry, 23 (7), 1590-1596. doi: 10.1038/mp.2017.130

Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia.

Witt, S. H., Streit, F., Jungkunz, M., Frank, J., Awasthi, S., Reinbold, C. S., Treutlein, J., Degenhardt, F., Forstner, A. J., Heilmann-Heimbach, S., Dietl, L., Schwarze, C. E., Schendel, D., Strohmaier, J., Abdellaoui, A., Adolfsson, R., Air, T. M., Akil, H., Alda, M., Alliey-Rodriguez, N., Andreassen, O. A., Babadjanova, G., Bass, N. J., Bauer, M., Baune, B. T., Bellivier, F., Bergen, S., Bethell, A., Biernacka, J. M. ... Rietschel, M. (2017). Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia.. Translational psychiatry, 7 (6), e1155-e1155. doi: 10.1038/tp.2017.115

Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression

Culverhouse, R. C., Saccone, N. L., Horton, A. C., Ma, Y., Anstey, K. J., Banaschewski, T., Burmeister, M., Cohen-Woods, S., Etain, B., Fisher, H. L., Goldman, N., Guillaume, S., Horwood, J., Juhasz, G., Lester, K. J., Mandelli, L., Middeldorp, C. M., Olie, E., Villafuerte, S., Air, T. M., Araya, R., Bowes, L., Burns, R., Byrne, E. M., Coffey, C., Coventry, W. L., Gawronski, K. A. B., Glei, D., Hatzimanolis, A. ... Bierut, L. J. (2017). Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. Molecular Psychiatry, 23 (1), 133-142. doi: 10.1038/mp.2017.44

Genetic effects influencing risk for major depressive disorder in China and Europe

Bigdeli, T. B., Ripke, S., Peterson, R. E., Trzaskowski, M., Bacanu, S-A, Abdellaoui, A., Andlauer, T. F. M., Beekman, A. T. F., Berger, K., Blackwood, D. H. R., Boomsma, D. I., Breen, G., Buttenschon, H. N., Byrne, E. M., Cichon, S., Clarke, T-K, Couvy-Duchesne, B., Craddock, N., de Geus, E. J. C., Degenhardt, F., Dunn, E. C., Edwards, A. C., Fanous, A. H., Forstner, A. J., Frank, J., Gill, M., Gordon, S. D., Grabe, H. J., Hamilton, S. P. ... Kendler, K. S. (2017). Genetic effects influencing risk for major depressive disorder in China and Europe. Translational Psychiatry, 7 (3) e1074, e1074-e1074. doi: 10.1038/tp.2016.292

Genome-wide regional heritability mapping identifies a locus within the TOX2 gene associated with major depressive disorder

Zeng, Yanni, Navarro, Pau, Shirali, Masoud, Howard, David M., Adams, Mark J., Hall, Lynsey S., Clarke, Toni-Kim, Thomson, Pippa A., Smith, Blair H., Murray, Alison, Padmanabhan, Sandosh, Hayward, Caroline, Boutin, Thibaud, MacIntyre, Donald J., Lewis, Cathryn M., Wray, Naomi R., Mehta, Divya, Penninx, Brenda W. J. H., Milaneschi, Yuri, Baune, Bernhard T., Air, Tracy, Hottenga, Jouke-Jan, Mbarek, Hamdi, Castelao, Enrique, Pistis, Giorgio, Schulze, Thomas G., Streit, Fabian, Forstner, Andreas J., Byrne, Enda M. ... McIntosh, Andrew M. (2016). Genome-wide regional heritability mapping identifies a locus within the TOX2 gene associated with major depressive disorder. Biological Psychiatry, 82 (5), 312-321. doi: 10.1016/j.biopsych.2016.12.012

Association of the polygenic risk score for schizophrenia with mortality and suicidal behavior - a Danish population-based study

Laursen, Thomas M., Trabjerg, Betina B., Mors, Ole, Borglum, Anders D., Hougaard, David M., Mattheisen, Manuel, Meier, Sandra M., Byrne, Enda M., Mortensen, Preben B., Munk-Olsen, Trine and Agerbo, Esben (2016). Association of the polygenic risk score for schizophrenia with mortality and suicidal behavior - a Danish population-based study. Schizophrenia Research, 184, 122-127. doi: 10.1016/j.schres.2016.12.001

Erratum: Meta-analysis of genome-wide association studies of anxiety disorders (vol 21, pg 1391, 2016)

Otowa, T., Hek, K., Lee, M., Byrne, E. M., Mirza, S. S., Nivard, M. G., Bigdeli, T., Aggen, S. H., Adkins, D., Wolen, A., Fanous, A., Keller, M. C., Castelao, E., Kutalik, Z., Auwera, S. V. der, Homuth, G., Nauck, M., Teumer, A., Milaneschi, Y., Hottenga, J-J, Direk, N., Hofman, A., Uitterlinden, A., Mulder, C. L., Henders, A. K., Medland, S. E., Gordon, S., Heath, A. C., Madden, P. A. F. ... Hettema, J. M. (2016). Erratum: Meta-analysis of genome-wide association studies of anxiety disorders (vol 21, pg 1391, 2016). Molecular Psychiatry, 21 (10), 1485-1485. doi: 10.1038/mp.2016.11

Genetic correlation analysis suggests association between increased self-reported sleep duration in adults and schizophrenia and type 2 diabetes

Byrne, Enda M., Gehrman, Philip R., Trzaskowski, Maciej, Tiemeier, Henning and Pack, Allan I. (2016). Genetic correlation analysis suggests association between increased self-reported sleep duration in adults and schizophrenia and type 2 diabetes. Sleep, 39 (10), 1853-1857. doi: 10.5665/sleep.6168

Genetic variants in RBFOX3 are associated with sleep latency

Amin, Najaf, Allebrandt, Karla V., van der Spek, Ashley, Müller-Myhsok, Bertram, Hek, Karin, Teder-Laving, Maris, Hayward, Caroline, Esko, Tõnu, van Mill, Josine G., Mbarek, Hamdi, Watson, Nathaniel F., Melville, Scott A., Del Greco, Fabiola M., Byrne, Enda M., Oole, Edwin, Kolcic, Ivana, Chen, Ting-hsu, Evans, Daniel S., Coresh, Josef, Vogelzangs, Nicole, Karjalainen, Juha, Willemsen, Gonneke, Gharib, Sina A., Zgaga, Lina, Mihailov, Evelin, Stone, Katie L., Campbell, Harry, Brouwer, Rutger W. W., Demirkan, Ayse ... van Duijn, Cornelia M. (2016). Genetic variants in RBFOX3 are associated with sleep latency. European Journal of Human Genetics, 24 (10), 1488-1495. doi: 10.1038/ejhg.2016.31

Meta-analysis of genome-wide association studies of anxiety disorders

Otowa, T., Hek, K., Lee, M., Byrne, E. M., Mirza, S. S., Nivard, M. G., Bigdeli, T., Aggen, S. H., Adkins, D., Wolen, A., Fanous, A., Keller, M. C., Castelao, E., Kutalik, Z., Der Auwera, S. V., Homuth, G., Nauck, M., Teumer, A., Milaneschi, Y., Hottenga, J. -J., Direk, N., Hofman, A., Uitterlinden, A., Mulder, C. L., Henders, A. K., Medland, S. E., Gordon, S., Heath, A. C., Madden, P. A. F. ... Hettema, J. M. (2016). Meta-analysis of genome-wide association studies of anxiety disorders. Molecular Psychiatry, 21 (10), 1391-1399. doi: 10.1038/mp.2015.197

Genome-wide association analyses in 128,266 individuals identifies new morningness and sleep duration loci

Jones, Samuel E., Tyrrell, Jessica, Wood, Andrew R., Beaumont, Robin N., Ruth, Katherine S., Tuke, Marcus A., Yaghootkar, Hanieh, Hu, Youna, Teder-Laving, Maris, Hayward, Caroline, Roenneberg, Till, Wilson, James F., Del Greco, Fabiola, Hicks, Andrew A., Shin, Chol, Yun, Chang-Ho, Lee, Seung Ku, Metspalu, Andres, Byrne, Enda M., Gehrman, Philip R., Tiemeier, Henning, Allebrandt, Karla V., Freathy, Rachel M., Murray, Anna, Hinds, David A., Frayling, Timothy M. and Weedon, Michael N. (2016). Genome-wide association analyses in 128,266 individuals identifies new morningness and sleep duration loci. PLoS Genetics, 12 (8) e1006125, e1006125-e1006125. doi: 10.1371/journal.pgen.1006125

An analysis of two genome-wide association meta-analyses identifies a new locus for broad depression phenotype

Direk, Nese, Williams, Stephanie, Smith, Jennifer A., Ripke, Stephan, Air, Tracy, Amare, Azmeraw T., Amin, Najaf, Baune, Bernhard T., Bennett, David A., Blackwood, Douglas H. R., Boomsma, Dorret, Breen, Gerome, Buttenschon, Henriette N., Byrne, Enda M., Borglum, Anders D., Castelao, Enrique, Cichon, Sven, Clarke, Toni-Kim, Cornelis, Marilyn C., Dannlowski, Udo, De Jager, Philip L., Demirkan, Ayse, Domenici, Enrico, van Duijn, Cornelia M., Dunn, Erin C., Eriksson, Johan G., Esko, Tonu, Faul, Jessica D., Ferrucci, Luigi ... Sullivan, Patrick F. (2016). An analysis of two genome-wide association meta-analyses identifies a new locus for broad depression phenotype. Biological Psychiatry, 82 (5), 322-329. doi: 10.1016/j.biopsych.2016.11.013

Genome-wide association for major depression through age at onset stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium

Power, Robert A., Tansey, Katherine E., Buttenschøn, Henriette Nørmølle, Cohen-Woods, Sarah, Bigdeli, Tim, Hall, Lynsey S., Kutalik, Zoltán, Lee, S. Hong, Ripke, Stephan, Steinberg, Stacy, Teumer, Alexander, Viktorin, Alexander, Wray, Naomi R., Arolt, Volker, Baune, Bernard T., Boomsma, Dorret I., Børglum, Anders D., Byrne, Enda M., Castelao, Enrique, Craddock, Nick, Craig, Ian, Dannlowski, Udo, Deary, Ian J., Degenhardt, Franziska, Forstner, Andreas J., Gordon, Scott D., Grabe, Hans J., Grove, Jakob, Hamilton, Steven P. ... Lewis, Cathryn M. (2016). Genome-wide association for major depression through age at onset stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Biological Psychiatry, 81 (4), 325-335. doi: 10.1016/j.biopsych.2016.05.010

Genetics of sleep disorders

Gehrman, Philip R., Keenan, Brendan T., Byrne, Enda M. and Pack, Allan I. (2015). Genetics of sleep disorders. Psychiatric Clinics of North America, 38 (4), 667-681. doi: 10.1016/j.psc.2015.07.004

Design and implementation of the international genetics and translational research in transplantation network

Keating, Brendan J., van Setten, Jessica, Jacobson, Pamala A., Holmes, Michael V., Verma, Shefali S., Chandrupatla, Hareesh R., Nair, Nikhil, Gao, Hui, Li, Yun R., Chang, Bao-Li, Wong, Chanel, Phillips, Randy, Cole, Brian S., Mukhtar, Eyas, Zhang, Weijia, Cao, Hongzhi, Mohebnasab, Maede, Hou, Cuiping, Lee, Takesha, Steel, Laura, Shaked, Oren, Garifallou, James, Miller, Michael B., Karczewski, Konrad J., Akdere, Abdullah, Gonzalez, Ana, Lloyd, Kelsey M., McGinn, Daniel, Michaud, Zach ... The International Genetics & Translational Research in Transplantation Network (2015). Design and implementation of the international genetics and translational research in transplantation network. Transplantation, 99 (11), 2401-2412. doi: 10.1097/TP.0000000000000913

The association between lower educational attainment and depression owing to shared genetic effects? results in ∼25 000 subjects

Peyrot, W. J., Lee, S. H., Milaneschi, Y., Abdellaoui, A., Byrne, E. M., Esko, T., de Geus, E. J. C., Hemani, G., Hottenga, J. J., Kloiber, S., Levinson, D. F., Lucae, S., Martin, N. G., Medland, S. E., Metspalu, A., Milani, L., Noethen, M. M., Potash, J. B., Rietschel, M., Rietveld, C. A., Ripke, S., Shi, J., Willemsen, G., Zhu, Z., Boomsma, D. I., Wray, N. R., Penninx, B. W. J. H., Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium and Middeldorp, Christel (2015). The association between lower educational attainment and depression owing to shared genetic effects? results in ∼25 000 subjects. Molecular Psychiatry, 20 (6), 735-743. doi: 10.1038/mp.2015.50

Genetic studies of body mass index yield new insights for obesity biology

Locke, Adam E., Kahali, Bratati, Berndt, Sonja I., Justice, Anne E., Pers, Tune H., Day, Felix R., Powell, Corey, Vedantam, Sailaja, Buchkovich, Martin L., Yang, Jian, Croteau-Chonka, Damien C., Esko, Tonu, Fall, Tove, Ferreira, Teresa, Gustafsson, Stefan, Kutalik, Zoltán, Luan, Jian'an, Mägi, Reedik, Randall, Joshua C., Winkler, Thomas W., Wood, Andrew R., Workalemahu, Tsegaselassie, Faul, Jessica D., Smith, Jennifer A., Zhao, Jing Hua, Zhao, Wei, Chen, Jin, Fehrmann, Rudolf, Hedman, Asa K. ... Shah, Sonia (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature, 518 (7538), 197-206. doi: 10.1038/nature14177

Heritability of Transforming Growth Factor-β1 and Tumor Necrosis Factor-Receptor Type 1 Expression and Vitamin D Levels in Healthy Adolescent Twins

Mills, Natalie T., Wright, Margaret J., Henders, Anjali K., Eyles, Darryl W., Baune, Bernhard T., McGrath, John J., Byrne, Edna M., Hansell, Narelle K., Birosova, Eva, Scott, James G., Martin, Nicholas G., Montgomery, Grant W., Wray, Naomi R. and Vinkhuyzen, Anna A. E. (2015). Heritability of Transforming Growth Factor-β1 and Tumor Necrosis Factor-Receptor Type 1 Expression and Vitamin D Levels in Healthy Adolescent Twins. Twin Research and Human Genetics, 18 (1), 28-35. doi: 10.1017/thg.2014.70

Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder

Byrne, Enda M, Raheja, Uttam K, Stephens, Sarah H, Heath, Andrew C, Madden, Pamela A, Vaswani, Dipika, Nijjar, Gagan V, Ryan, Kathleen A, Youssufi, Hassaan, Gehrman, Philip R, Shuldiner, Alan R, Martin, Nicholas G, Montgomery, Grant W, Wray, Naomi R, Nelson, Elliot C, Mitchell, Braxton D, Postolache, Teodor T, Psychiatric Genetics Consortium Major Depressive Disorder Working Group and Middeldorp, Christel (2015). Seasonality shows evidence for polygenic architecture and genetic correlation with schizophrenia and bipolar disorder. Journal of Clinical Psychiatry, 76 (2), 128-134. doi: 10.4088/JCP.14m08981

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

O'Dushlaine, Colm, Rossin, Lizzy, Lee, Phil H., Duncan, Laramie, Parikshak, Neelroop N., Newhouse, Stephen, Ripke, Stephan, Neale, Benjamin M., Purcell, Shaun M., Posthuma, Danielle, Nurnberger, John I., Lee, S. Hong, Faraone, Stephen V., Perlis, Roy H., Mowry, Bryan J, Thapar, Anita, Goddard, Michael E., Witte, John S., Absher, Devin, Agartz, Ingrid, Akil, Huda, Amin, Farooq, Andreassen, Ole A., Anjorin, Adebayo, Anney, Richard, Anttila, Verneri, Arking, Dan E., Asherson, Philip, Azevedo, Maria H. ... Breen, Gerome (2015). Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nature Neuroscience, 18 (2), 199-209. doi: 10.1038/nn.3922

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis

Lee, S. Hong, Byrne, Enda M., Hultman, Christina M., Kahler, Anna, Vinkhuyzen, Anna A. E., Ripke, Stephan, Andreassen, Ole A., Frisell, Thomas, Gusev, Alexander, Hu, Xinli, Karlsson, Robert, Mantzioris, Vasilis X., McGrath, John J., Mehta, Divya, Stahl, Eli A., Zhao, Qiongyi, Kendler, Kenneth S., Sullivan, Patrick F., Price, Alkes L., O'Donovan, Michael, Okada, Yukinori, Mowry, Bryan J., Raychaudhuri, Soumya, Wray, Naomi R., Schizophrenia Working Group of the Psychiatric Genomics Consortium, Rheumatoid Arthritis Consortium International and Visscher, Peter M . (2015). New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis. International Journal of Epidemiology, 44 (5) dyv136, 1-16. doi: 10.1093/ije/dyv136

Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study

Gottlieb, D. J., Hek, K., Chen, T. H., Watson, N. F., Eiriksdottir, G., Byrne, E. M., Cornelis, M., Warby, S. C., Bandinelli, S., Cherkas, L., Evans, D. S., Grabe, H. J., Lahti, J., Li, M., Lehtimaki, T., Lumley, T., Marciante, K. D., Perusse, L., Psaty, B. M., Robbins, J., Tranah, G. J., Vink, J. M., Wilk, J. B., Stafford, J. M., Bellis, C., Biffar, R., Bouchard, C., Cade, B., Curhan, G. C. ... Tiemeier, H. (2014). Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study. Molecular Psychiatry, 20 (10), 1232-1239. doi: 10.1038/mp.2014.133

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

The Coffee and Caffeine Genetics Consortium, Cornelis, M. C., Byrne, E. M., Esko, T., Nalls, M. A., Ganna, A., Paynter, N., Monda, K. L., Amin, N., Fischer, K., Renstrom, F., Ngwa, J. S., Huikari, V., Cavadino, A., Nolte, I. M., Teumer, A., Yu, K., Marques-Vidal, P., Rawa, R., Manichaikul, A., Wojczynski, M. K., Vink, J.,M., Zhao, J. H., Burlutsky, G., Lahti, J., Mikkila, V., Lemaitre,R. N., Eriksson, J., Musani, S. K. ... UK Brain Expression Consortium (UKBEC) (2014). Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Molecular Psychiatry, 20 (5), 647-656. doi: 10.1038/mp.2014.107

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

Perry, John R. B., Day, Felix, Elks, Cathy E., Sulem, Patrick, Thompson, Deborah J., Ferreira, Teresa, He, Chunyan, Chasman, Daniel I., Esko, Toenu, Thorleifsson, Gudmar, Albrecht, Eva, Ang, Wei Q., Corre, Tanguy, Cousminer, Diana L., Feenstra, Bjarke, Franceschini, Nora, Ganna, Andrea, Johnson, Andrew D., Kjellqvist, Sanela, Lunetta, Kathryn L., McMahon, George, Nolte, Ilja M., Paternoster, Lavinia, Porcu, Eleonora, Smith, Albert V., Stolk, Lisette, Teumer, Alexander, Tsernikova, Natalia, Tikkanen, Emmi ... Middeldorp, Christel (2014). Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature, 514 (7520), 92-97. doi: 10.1038/nature13545

Applying polygenic risk scores to postpartum depression

Byrne, Edna M., Carrillo-Roa, Tania, Penninx, Brenda W. J. H., Sallis, Hannah M., Viktorin, Alexander, Chapman, Brett, Henders, Anjali K., Pergadia, Michele L., Heath, Andrew C., Madden, Pamela A. F., Sullivan, Patrick F., Boschloo, Lynn, van Grootheest, Gerard, McMahon, George, Lawlor, Debbie A., Landen, Mikael, Lichtenstein, Paul, Magnusson, Patrik K. E., Evans, David M., Montgomery, Grant W., Boomsma, Dorret I., Martin, Nicholas G., Meltzer-Brody, Samantha and Wray, Naomi R. (2014). Applying polygenic risk scores to postpartum depression. Archives of Women's Mental Health, 17 (6), 519-528. doi: 10.1007/s00737-014-0428-5

Hypermethylation in the ZBTB20 gene is associated with major depressive disorder

Davies, Matthew N., Krause, Lutz, Bell, Jordana T., Gao, Fei, Ward, Kirsten J., Wu, Honglong, Lu, Hanlin, Liu, Yuan, Tsai, Pei-Chein, Collier, David A., Murphy, Therese, Dempster, Emma, Mill, Jonathan, UK Brain Expression Consortium, Battle, Alexis, Mostafavi, Sara, Zhu, Xiaowei, Henders, Anjali, Byrne, Enda, Wray, Naomi R., Martin, Nicholas G., Spector, Tim D. and Wang, Jun (2014). Hypermethylation in the ZBTB20 gene is associated with major depressive disorder. Genome Biology, 15 (4) R56, R56.1-R56.12. doi: 10.1186/gb-2014-15-4-r56

Genetic risk score analysis indicates migraine with and without comorbid depression are genetically different disorders

Ligthart, Lannie, Hottenga, Jouke-Jan, Lewis, Cathryn M., Farmer, Anne E., Craig, Ian W., Breen, Gerome, Willemsen, Gonneke, Vink, Jacqueline M., Middeldorp, Christel M., Byrne, Enda M., Heath, Andrew C., Madden, Pamela A. F., Pergadia, Michele L., Montgomery, Grant W., Martin, Nicholas G., Penninx, Brenda W. J. H., McGuffin, Peter, Boomsma, Dorret I. and Nyholt, Dale R. (2014). Genetic risk score analysis indicates migraine with and without comorbid depression are genetically different disorders. Human Genetics, 133 (2), 173-186. doi: 10.1007/s00439-013-1370-8

Testing the role of circadian genes in conferring risk for psychiatric disorders

Byrne, Enda M., Heath, Andrew C., Madden, Pamela A. F., Pergadia, Michele L., Hickie, Ian B., Montgomery, Grant W., Martin, Nicholas G. and Wray, Naomi R. (2014). Testing the role of circadian genes in conferring risk for psychiatric disorders. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 165 (3), 254-260. doi: 10.1002/ajmg.b.32230

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

Lee, S. Hong, Ripke, Stephan, Neale, Benjamin M., Faraone, Stephen V., Purcell, Shaun M., Perlis, Roy H., Mowry, Bryan J., Thapar, Anita, Goddard, Michael E., Witte, John S., Absher, Devin, Agartz, Ingrid, Akil, Huda, Amin, Farooq, Andreassen, Ole A., Anjorin, Adebayo, Anney, Richard, Anttila, Verneri, Arking, Dan E., Asherson, Philip, Azevedo, Maria H., Backlund, Lena, Badner, Judith A., Bailey, Anthony J., Banaschewski, Tobias, Barchas, Jack D., Barnes, Michael R., Barrett, Thomas B., Bass, Nicholas ... Wray, Naomi R. (2013). Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics, 45 (9), 984-995. doi: 10.1038/ng.2711

The role of genes in the insomnia phenotype

Gehrman, Philip R., Pfeiffenberger, Cory and Byrne, Enda M. (2013). The role of genes in the insomnia phenotype. Sleep Medicine Clinics, 8 (3), 323-331. doi: 10.1016/j.jsmc.2013.04.005

Association of adiposity genetic variants with menarche timing in 92,105 women of European descent

Fernández-Rhodes, Lindsay, Demerath, Ellen W., Cousminer, Diana L., Tao, Ran, Dreyfus, Jill G., Esko, Tõnu, Smith, Albert V., Gudnason, Vilmundur, Harris, Tamara B., Launer, Lenore, McArdle, Patrick F., Yerges-Armstrong, Laura M., Elks, Cathy E., Strachan, David P., Kutalik, Zoltán, Vollenweider, Peter, Feenstra, Bjarke, Boyd, Heather A., Metspalu, Andres, Mihailov, Evelin, Broer, Linda, Zillikens, M. Carola, Oostra, Ben, van Duijn, Cornelia M., Lunetta, Kathryn L., Perry, John R. B., Murray, Anna, Koller, Daniel L., Lai, Dongbing ... Franceschini, Nora (2013). Association of adiposity genetic variants with menarche timing in 92,105 women of European descent. American Journal of Epidemiology, 178 (3), 451-460. doi: 10.1093/aje/kws473

Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity

Cousminer D.L., Berry D.J., Timpson N.J., Ang W., Thiering E., Byrne E.M., Rob Taal H., Huikari V., Bradfield J.P., Kerkhof M., Groen-Blokhuis M.M., Kreiner-Moller E., Marinelli M., Holst C., Leinonen J.T., Perry J.R.B., Surakka I., Pietilainen O., Kettunen J., Anttila V., Kaakinen M., Sovio U., Pouta A., Das S., Lagou V., Power C., Prokopenko I., Evans D.M., Kemp J.P. ... Middeldorp, Christel (2013). Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Human Molecular Genetics, 22 (13), 2735-2747. doi: 10.1093/hmg/ddt104

Monozygotic twins affected with major depressive disorder have greater variance in methylation than their unaffected co-twin

Byrne, E. M., Carrillo-Roa, T., Henders, A. K., Bowdler, L., McRae, A. F., Heath, A. C., Martin, N. G., Montgomery, G. W., Krause, L. and Wray, N. R. (2013). Monozygotic twins affected with major depressive disorder have greater variance in methylation than their unaffected co-twin. Translational Psychiatry, 3 (6) e269, e269.1-e269.6. doi: 10.1038/tp.2013.45

A genome-wide association study of sleep habits and insomnia

Byrne, Enda M., Gehrman, Philip R., Medland, Sarah E., Nyholt, Dale R., Heath, Andrew C., Madden, Pamela A. F., Hickie, Ian B., Van Duijn, Cornelia M., Henders, Anjali K., Montgomery, Grant W., Martin, Nicholas G., Wray, Naomi R. and The Chronogen Consortium (2013). A genome-wide association study of sleep habits and insomnia. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 162 (5), 439-451. doi: 10.1002/ajmg.b.32168

A mega-analysis of genome-wide association studies for major depressive disorder

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Wray, Naomi, Byrne, Enda M., Martin, Nicholas G., Gordon, Scott D., Henders, Anjali K., Montgomery, Grant M., Nyholt, Dale R. and Middeldorp, Christel M. (2013). A mega-analysis of genome-wide association studies for major depressive disorder. Molecular Psychiatry, 18 (4), 497-511. doi: 10.1038/mp.2012.21

Selected rapporteur summaries from the XX world congress of psychiatric genetics, Hamburg, Germany, October 14-18, 2012

Anderson-Schmidt, Heike, Beltcheva, Olga, Brandon, Mariko D., Byrne, Enda M., Diehl, Eric J., Duncan, Laramie, Gonzalez, Suzanne D., Hannon, Eilis, Kantojarvi, Katri, Karagiannidis, Iordanis, Kos, Mark Z., Kotyuk, Eszter, Laufer, Benjamin I., Mantha, Katarzyna, McGregor, Nathaniel W., Meier, Sandra, Nieratschker, Vanessa, Spiers, Helen, Squassina, Alessio, Thakur, Geeta A., Tiwari, Yash, Viswanath, Biju, Way, Michael J., Wong, Cybele C. P., O'Shea, Anne and DeLisi, Lynn E. (2013). Selected rapporteur summaries from the XX world congress of psychiatric genetics, Hamburg, Germany, October 14-18, 2012. American Journal of Medical Genetics Part B-Neuropsychiatric Genetics, 162 (2), 96-121. doi: 10.1002/ajmg.b.32132

Modeling the direction of causation between cross-sectional measures of disrupted sleep, anxiety and depression in a sample of male and female Australian twins

Gillespie, Nathan A., Gehrman, Philip, Byrne, Enda M., Kendler, Kenneth S., Heath, Andrew C. and Martin, Nicholas G. (2012). Modeling the direction of causation between cross-sectional measures of disrupted sleep, anxiety and depression in a sample of male and female Australian twins. Journal of Sleep Research, 21 (6), 675-683. doi: 10.1111/j.1365-2869.2012.01026.x

Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder

Lee, P. H., Perlis, R. H., Jung, J-Y, Byrne, E. M., Rueckert, E., Siburian, R., Haddad, S., Mayerfeld, C. E., Heath, A. C., Pergadia, M. L., Madden, P. A. F., Boomsma, D. I., Penninx, B. W., Sklar, P., Martin, N. G., Wray, N. R., Purcell, S. M. and Smoller, J. W. (2012). Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder. Translational Psychiatry, 2 (11) e184, e184.1-e184.9. doi: 10.1038/tp.2012.95

Unraveling the genetic etiology of adult antisocial behavior: a genome-wide association study

Tielbeek, Jorim J., Medland, Sarah E., Benyamin, Beben, Byrne, Enda M., Heath, Andrew C., Madden, Pamela A. F., Martin, Nicholas G., Wray, Naomi R. and Verweij, Karin J. H. (2012). Unraveling the genetic etiology of adult antisocial behavior: a genome-wide association study. PLoS One, 7 (10) e45086, e1005378-e1005378. doi: 10.1371/journal.pone.0045086

A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor

Byrne, Enda M., Johnson, Julie, McRae, Allan F., Nyholt, Dale R., Medland, Sarah E., Gehrman, Philip R., Heath, Andrew C., Madden, Pamela A. F., Montgomery, Grant W., Chenevix-Trench, Georgia and Martin, Nicholas G. (2012). A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor. Sleep, 35 (7), 967-975. doi: 10.5665/sleep.1962

Introduction: What is a 'gene' and why does it matter for political science?

Hatemi, Peter K., Byrne, Enda and McDermott, Rose (2012). Introduction: What is a 'gene' and why does it matter for political science?. Journal of Theoretical Politics, 24 (3), 305-327. doi: 10.1177/0951629812437752

Genome-wide association study of major depressive disorder: New results, meta-analysis, and lessons learned

Wray, N. R., Pergadia, M. L., Blackwood, D. H. R., Penninx, B. W. J. H., Gordon, S. D., Nyholt, D. R., Ripke, S., MacIntyre, D. J., McGhee, K. A., MacLean, A. W., Smit, J. H., Hottenga, J. J., Willemsen, G., Middeldorp, C. M., De Geus, E. J. C., Lewis, C. M., McGuffin, P., Hickie, I. B., Van Den Oord, E. J. C. G., Liu, J. Z., MacGregor, S., McEvoy, B. P., Byrne, E. M., Medland, S. E., Statham, D. J., Henders, A. K., Heath, A. C., Montgomery, G. W., Martin, N. G. ... Sullivan, P. F. (2012). Genome-wide association study of major depressive disorder: New results, meta-analysis, and lessons learned. Molecular Psychiatry, 17 (1), 36-48. doi: 10.1038/mp.2010.109

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

Stolk L., Perry J.R.B., Chasman D.I., He C., Mangino M., Sulem P., Barbalic M., Broer L., Byrne E.M., Ernst F., Esko T., Franceschini N., Gudbjartsson D.F., Hottenga J.-J., Kraft P., McArdle P.F., Porcu E., Shin S.-Y., Smith A.V., Van Wingerden S., Zhai G., Zhuang W.V., Albrecht E., Alizadeh B.Z., Aspelund T., Bandinelli S., Lauc L.B., Beckmann J.S., Boban M. ... Lunetta K.L. (2012). Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nature Genetics, 44 (3), 260-268. doi: 10.1038/ng.1051

Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM

Amin, N., Byrne, E., Johnson, J., Chenevix-Trench, G., Walter, S., Nolte, I. M., kConFab Investigators, Vink, J.M., Rawal, R., Mangino, M., Teumer, A., Keers, J. C., Verwoert, G., Baumeister, S., Biffar, R., Petersmann, A., Dahmen, N., Doering, A., Isaacs, A., Broer, L., Wray, N. R., Montgomery, G. W., Levy, D., Psaty, B. M., Gudnason, V., Chakravarti, A., Sulem, P., Gudbjartsson, D. F., Kiemeney, L. A. ... van Duijn, C. M. (2011). Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. Molecular Psychiatry, 17 (11), 1116-1129. doi: 10.1038/mp.2011.101

Genetics of insomnia

Gehrman, Philip R., Byrne, Enda, Gillespie, Nathan and Martin, Nicholas G. (2011). Genetics of insomnia. Sleep Medicine Clinics, 6 (2), 191-202. doi: 10.1016/j.jsmc.2011.03.003

A genome-wide analysis of liberal and conservative political attitudes

Hatemi, Peter K., Gillespie, Nathan A., Eaves, Lindon J., Maher, Brion S., Webb, Bradley T., Heath, Andrew C., Medland, Sarah E., Smyth, David C., Beeby, Harry N., Gordon, Scott D., Montgomery, Grant W., Zhu, Ghu, Byrne, Enda M. and Martin, Nicholas G. (2011). A genome-wide analysis of liberal and conservative political attitudes. Journal of Politics, 73 (1), 271-285. doi: 10.1017/S0022381610001015

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

Elks, C. E., Perry, J. R. B., Sulem, P., Chasman, D. I., Franceschini, N., He, C. Y., Lunetta, K. L., Visser, J. A., Byrne, E. M., Cousminer, D. L., Gudbjartsson, D. F., Esko, T., Feenstra, B., Hottenga, J. J., Koller, D. L., Kutalik, Z., Lin, P., Mangino, M., Marongiu, M., McArdle, P. F., Smith, A. V., Stolk, L., Van Wingerden, S. H., Zhao, J. H., Albrecht, E., Corre, T., Ingelsson, E., Hayward, C., Magnusson, P. K. E. ... GIANT Consortium (2010). Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nature Genetics, 42 (12), 1077-1085. doi: 10.1038/ng.714

Cross-Disorder Genomewide Analysis of Schizophrenia, Bipolar Disorder, and Depression

Huang, Jie, Perlis, Roy H., Lee, Phil H., Rush, A. John, Fava, Maurizio, Sachs, Gary S., Lieberman, Jeffrey, Hamilton, Steven P., Sullivan, Patrick, Sklar, Pamela, Purcell, Shaun and Smoller, Jordan W. (2010). Cross-Disorder Genomewide Analysis of Schizophrenia, Bipolar Disorder, and Depression. American Journal of Psychiatry, 167 (10), 1254-1263. doi: 10.1176/appi.ajp.2010.09091335

Family-based mitochondrial association study of traits related to type 2 diabetes and the metabolic syndrome in adolescents

E. M. Byrne, A. F. McRae, D. L. Duffy, Z. Z. Zhao, N. G. Martin, J. B. Whitfield, P. M. Visscher and G. W. Montgomery (2009). Family-based mitochondrial association study of traits related to type 2 diabetes and the metabolic syndrome in adolescents. Diabetologia, 52 (11), 2359-2368. doi: 10.1007/s00125-009-1510-9

Association Study of Common Mitochondrial Variants and Cognitive Ability

Byrne, EM, McRae, AF, Duffy, DL, Zhao, ZZ, Martin, NG, Wright, MJ, Montgomery, GW and Visscher, PM (2009). Association Study of Common Mitochondrial Variants and Cognitive Ability. BEHAVIOR GENETICS, 39 (5), 504-512. doi: 10.1007/s10519-009-9276-x

The use of common mitochondrial variants to detect and characterise population structure in the Australian population: Implications for genome-wide association studies

Byrne, Enda M., Mcrae, Allan F., Zhao, Zhen-Zhen, Martin, Nicholas G., Montgomery, Grant W. and Visscher, Peter M. (2008). The use of common mitochondrial variants to detect and characterise population structure in the Australian population: Implications for genome-wide association studies. European Journal of Human Genetics, 16 (11), 1396-1403. doi: 10.1038/ejhg.2008.117

Power and SNP tagging in whole mitochondrial genome association studies

McRae, Allan F., Byrne, Enda M., Zhao, Zhen Zhen, Montgomery, Grant W. and Visscher, Peter M. (2008). Power and SNP tagging in whole mitochondrial genome association studies. Genome Research, 18 (6), 911-917. doi: 10.1101/gr.074872.107

The influence of twin pair permutation on likelihood-based-estimates of genetic variance that require ordering of twin-pairs

Byrne, Enda, Stillitano, Maria, Williams, Christopher J. and Christian, Joe C. (2007). The influence of twin pair permutation on likelihood-based-estimates of genetic variance that require ordering of twin-pairs. Behavior Genetics, 37 (4), 617-620. doi: 10.1007/s10519-007-9154-3

Symptom-level genetic modelling identifies novel risk loci and unravels the shared genetic architecture of anxiety and depression

Thorp, Jackson G., Campos, Adrian I., Grotzinger, Andrew D., Gerring, Zachary, An, Jiyuan, Ong, Jue-Sheng, Wang, Wei, Shringarpure, Suyash, Byrne, Enda M., MacGregor, Stuart, Martin, Nicholas G., Medland, Sarah E., Middeldorp, Christel M. and Derks, Eske M. (2020). Symptom-level genetic modelling identifies novel risk loci and unravels the shared genetic architecture of anxiety and depression. 50th Annual Meeting of the Behavior-Genetics-Association (BGA), Electr Network, Jun 26, 2020. NEW YORK: SPRINGER.

The relationship between comorbid chronic pain and poorer self-reported antidepressant efficacy is partly mediated by genetics

Campos, Adrián I., Roughan, William H., García-Marin, Luis M., Cuéllar-Partida, Gabriel, Lupton, Michelle K., Hickie, Ian B., Medland, Sarah E., Wray, Naomi R., Byrne, Enda M., Ngo, Trung T., Martin, Nicholas G. and Rentería, Miguel E. (2020). The relationship between comorbid chronic pain and poorer self-reported antidepressant efficacy is partly mediated by genetics. Virtual 2020 World Congress of Psychiatric Genetics (WCPG), Online, 16–22 October 2020.

A direct test of the diathesis-stress model for depression

Conde, Lucia Colodro, Couvy-Duchesne, Baptiste, Zhu, Gu, Coventry, William, Byrne, Enda, Gordon, Scott, Wright, Margaret, Montgomery, Grant, Madden, Pamela, Ripke, Stephan, Eaves, Lindon, Heath, Andrew, Wray, Naomi, Medland, Sarah E. and Martin, Nick (2019). A direct test of the diathesis-stress model for depression. 25th World Congress of Psychiatric Genetics (WCPG), Orlando, FL United States, 13-17 October 2017. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2017.08.045

Assessing clinical, demographic and genetic risk factors for treatment attributed suicidality in > 20,000 Australian adults on antidepressants

Campos, Adrian, Renteria, Miguel E., Byrne, Enda, Medland, Sarah E., Wray, Naomi, Hickie, Ian B. and Martin, Nick (2019). Assessing clinical, demographic and genetic risk factors for treatment attributed suicidality in > 20,000 Australian adults on antidepressants. 27th World Congress of Psychiatric Genetics (WCPG), Los Angeles, United States, 26-31 October 2019. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2019.07.212

Comprehensive evaluation of enrichment for circadian clock gene sets in psychiatric traits: specific enrichment in clinical response to lithium

Papiol, Sergi, Heilbronner, Urs, Hou, Liping, McCarthy, Michael, Nievergelt, Caroline, Byrne, Enda, McMahon, Francis and Schulze, Thomas (2019). Comprehensive evaluation of enrichment for circadian clock gene sets in psychiatric traits: specific enrichment in clinical response to lithium. 25th World Congress of Psychiatric Genetics (WCPG), Orlando, FL, United States, 13-17 October 2017. Amsterdam, The Netherlands: Elsevier . doi: 10.1016/j.euroneuro.2017.08.270

Conditional genome-wide association analysis identifies genetic variants

Byrne, E. (2019). Conditional genome-wide association analysis identifies genetic variants. 21st Annual ISBD Conference: Global Advances in Bipolar Disorder and Depression, Sydney, Australia, 20-23 March 2019. Hoboken, NJ United States: Wiley-Blackwell Publishing.

Examining the shared genetics between educational attainment and depression: results from the Australian Genetics of Depression Study

Mitchell, Brittany, Renteria, Miguel E., Byrne, Enda, Conde, Lucia Colodro, Han, Xikun, Medland, Sarah E., Wray, Naomi and Martin, Nick (2019). Examining the shared genetics between educational attainment and depression: results from the Australian Genetics of Depression Study. 27th World Congress of Psychiatric Genetics, Los Angeles, United States, 26-31 October 2019. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2019.07.172

Exploring the heterogeneity of depression: stressful life events and depressive symptoms

Conde, Lucia Colodro, Couvy-Duchesne, Baptiste, Byrne, Enda, Campos, Adrian, Martin, Nick and Medland, Sarah (2019). Exploring the heterogeneity of depression: stressful life events and depressive symptoms. 27th World Congress of Psychiatric Genetics (WCPG), Los Angeles, CA, United States, 26-31 October 2019. Amsterdam, The Netherlands: Elsevier . doi: 10.1016/j.euroneuro.2019.08.109

Genetic risk for depression and treatment response in the Australian genetics of depression study

Byrne, Enda, Medland, Sarah E., Hickie, Ian, Martin, Nicholas G. and Wray, Naomi (2019). Genetic risk for depression and treatment response in the Australian genetics of depression study. 27th World Congress of Psychiatric Genetics (WCPG), Los Angeles, CA, United States, 26-31 October 2019. Amsterdam, The Netherlands: Elsevier . doi: 10.1016/j.euroneuro.2019.07.109

Genetic risk scores and postpartum psychiatric disorders

Bauer, Anna, Liu, Xiaoqin, Byrne, Enda, Sullivan, Patrick, Wray, Naomi, Agerbo, Esben, Nyegaard, Mette, Ingstrup, Katja, Johannsen, Benedicte, Maegbaek, Merete, Wang, Yunpeng, Nordentoft, Merete, Mortensen, Preben Bo, Munk-Olsen, Trine and Meltzer-Brody, Samantha (2019). Genetic risk scores and postpartum psychiatric disorders. 26th World Congress of Psychiatric Genetics (WCPG), Glasgow, Scotland, 11-15 October 2018. Amsterdam, The Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2018.08.048

Genomic structural equation models of major depression symptoms

Adams, Mark, Grotzinger, Andrew, Jermy, Bradley, Thorp, Jackson, Nivard, Michel, Byrne, Enda, Hickie, Ian, Martin, Nick, Medland, Sarah, Wray, Naomi, Tucker-Drob, Elliot, Lewis, Cathryn, Derks, Eske and McIntosh, Andrew (2019). Genomic structural equation models of major depression symptoms. 27th World Congress of Psychiatric Genetics (WCPG), Los Angeles, CA, United States, 26-31 October 2019. Amsterdam, The Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2019.08.042

INVESTIGATING CAUSAL RELATIONSHIPS BETWEEN MAJOR DEPRESSIVE DISORDER AND GENETICALLY CORRELATED TRAITS USING MENDELIAN RANDOMISATION

Byrne, Enda, Trzaskowski, Maciej and Wray, Naomi (2019). INVESTIGATING CAUSAL RELATIONSHIPS BETWEEN MAJOR DEPRESSIVE DISORDER AND GENETICALLY CORRELATED TRAITS USING MENDELIAN RANDOMISATION. 25th World Congress of Psychiatric Genetics (WCPG), Orlando Fl, Oct 13-17, 2017. AMSTERDAM: ELSEVIER SCIENCE BV. doi: 10.1016/j.euroneuro.2017.08.020

Identification of genetic risk factors for postpartum depression

Guintivano, Jerry, Byrne, Enda, Watson, Hunna, Wray, Naomi, Meltzer-Brody, Samantha and Sullivan, Patrick (2019). Identification of genetic risk factors for postpartum depression. 27th World Congress of Psychiatric Genetics, Los Angeles, United States, 26-31 October 2019. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2019.07.194

Integrative analysis of genome-wide association study results of attention-deficit/hyperactivity disorder (ADHD) and human fetal brain methylation data reveals novel genes associated with ADHD

Hammerschlag, Anke, Byrne, Enda, Bartels, Meike, Wray, Naomi and Middeldorp, Christel M. (2019). Integrative analysis of genome-wide association study results of attention-deficit/hyperactivity disorder (ADHD) and human fetal brain methylation data reveals novel genes associated with ADHD. 26th World Congress of Psychiatric Genetics (WCPG), Glasgow, Scotland, 11-15 October 2018. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2018.08.063

Sleep disorders and risk of incident depression: a population case-control study

Byrne, Enda, Wray, Naomi and Agerbo, Esben (2019). Sleep disorders and risk of incident depression: a population case-control study. 25th World Congress of Psychiatric Genetics (WCPG), Orlando, FL, United States, 13-17 October 2017. Amsterdam, The Netherlands: Elsevier . doi: 10.1016/j.euroneuro.2017.08.343

Validating GWA associations in psychiatric disorders with functional genomic data

Trzaskowski, Maciej, Byrne, Enda, Yang, Jian and Wray, Naomi (2019). Validating GWA associations in psychiatric disorders with functional genomic data. 25th World Congress of Psychiatric Genetics (WCPG), Orlando, FL, United States, 13-17 October 2017. Amsterdam, The Netherlands: Elsevier . doi: 10.1016/j.euroneuro.2017.08.019

PHENOTYPIC AND GENETIC ASSOCIATIONS BETWEEN SCHIZOPHRENIA AND RETINAL VESSEL DIAMETER

Meier, Madeline, Byrne, Enda, Martin, Nicholas, Wong, Tien and Sim, Xueling (2018). PHENOTYPIC AND GENETIC ASSOCIATIONS BETWEEN SCHIZOPHRENIA AND RETINAL VESSEL DIAMETER. 6th Biennial Conference of the Schizophrenia-International-Research-Society (SIRS), Florence Italy, Apr 04-08, 2018. OXFORD: OXFORD UNIV PRESS.

ENRICHMENT OF GENETIC VARIANTS ASSOCIATED WITH CLINICAL RESPONSE TO LITHIUM IN CIRCADIAN CLOCK SYSTEM GENE SETS

Heilbronner, Urs, Papiol, Sergi, McCarthy, Michael, Nievergelt, Caroline, Byrne, Enda and Schulze, Thomas G. (2017). ENRICHMENT OF GENETIC VARIANTS ASSOCIATED WITH CLINICAL RESPONSE TO LITHIUM IN CIRCADIAN CLOCK SYSTEM GENE SETS. 24th World Congress of Psychiatric Genetics (WCPG), Jerusalem Israel, Oct 30-Nov 04, 2016. AMSTERDAM: ELSEVIER SCIENCE BV. doi: 10.1016/j.euroneuro.2016.09.414

Shared genetic risk factors between schizophrenia and sleep quality in a population-based cohort of Australian twins

Byrne, E. and Martin, N. (2017). Shared genetic risk factors between schizophrenia and sleep quality in a population-based cohort of Australian twins. 23rd Annual World Congress of Psychiatric Genetics (WCPG), Toronto, Canada, 16-20 October 2017. Elsevier.

The genetics of sleep behaviour

Byrne, Enda and Byrne, Enda (2016). The genetics of sleep behaviour. 46th Annual Meeting of the Behavior-Genetics-Association, Brisbane Australia, Jun 20-23, 2016. NEW YORK: ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD.

Genetic correlation analysis suggests association between increased self-reported sleep duration in adults and schizophrenia and type-2 diabetes

Byrne, E., Gehrman, P. R., Tiemeier, H. and Pack, A. I. (2016). Genetic correlation analysis suggests association between increased self-reported sleep duration in adults and schizophrenia and type-2 diabetes. 28th ASM of Australasian Sleep Association and Australasian Sleep Technologists Association, Adelaide Convention Centre, 20-22 October 2016. HOBOKEN: Wiley. doi: 10.1111/jsr.12453

Sleep disorders and risk of incident depression: A population case-control study

Byrne, E. and Agerbo, E. (2016). Sleep disorders and risk of incident depression: A population case-control study. 28th ASM of Australasian Sleep Association and Australasian Sleep Technologists Association, Adelaide Convention Centre, 20-22 October 2016. HOBOKEN: Wiley. doi: 10.1111/jsr.12453

Early Career Psychiatrists Special Interest Group Symposium

Mills, N., Nelson, E., Scott, J., Whitfield, J., Martin, N., Wright, M., Wray, N., Byrne, E. and Martin, J. (2015). Early Career Psychiatrists Special Interest Group Symposium. The Royal Australian and New Zealand College of Psychiatrists 2015 Congress: Measurers and Thinkers: Psychiatry as Science and Art, Brisbane, QLD Australia, 3-15 May 2015. London, United Kingdom: Sage Publications. doi: 10.1177/0004867415578344

Investigating the Relationship Between C-Reactive Protein Genetic Profile Scores and Depression

Mills, N., Nelson, E., Scott, J., Whitfield, J., Martin, N., Wright, M., Wray, N. and Byrne, E. (2015). Investigating the Relationship Between C-Reactive Protein Genetic Profile Scores and Depression. The Royal Australian and New Zealand College of Psychiatrists 2015 Congress: Measurers and Thinkers: Psychiatry as Science and Art, Brisbane, QLD Australia, 3-15 May 2015. London, United Kingdom: Sage Publications. doi: 10.1177/0004867415578344

Using C-Reactive Protein Genetic Profile Scores to Predict Risk of Anxiety

Mills, N., Scott, J., Whitfield, J., Wright, M., Martin, N., Wray, N. and Byrne, E. (2015). Using C-Reactive Protein Genetic Profile Scores to Predict Risk of Anxiety. The Royal Australian and New Zealand College of Psychiatrists 2015 Congress: Measurers and Thinkers: Psychiatry as Science and Art, Brisbane, QLD Australia, 3-15 May 2015. London, United Kingdom: Sage Publications. doi: 10.1177/0004867415578344

New Data to Investigate an Old Epidemiological Puzzle: The Negative Association Between Schizophrenia and Rheumatoid Arthritis

Byrne, Enda (2014). New Data to Investigate an Old Epidemiological Puzzle: The Negative Association Between Schizophrenia and Rheumatoid Arthritis. 53rd Annual Meeting of the American-College-of-Neuropsychopharmacology (ACNP), Phoenix Az, Dec 07-11, 2014. LONDON: NATURE PUBLISHING GROUP.

Mitochondrial and Autosomal Genetic Analyses in the Australian Population

Enda Byrne (2010). Mitochondrial and Autosomal Genetic Analyses in the Australian Population. PhD Thesis, School of Medicine, The University of Queensland.