Dr Yuanhao Yang

Honorary Research Fellow

Mater Research Institute-UQ
Faculty of Medicine

Overview

Dr. Yuanhao Yang is research fellow at Mater Research Institute, with high-level expertise in computational and statistical genetics and genomics. His research field focuses on understanding the genetic and genomic etiology of human complex traits and common diseases, such as multiple sclerosis, depression and autism, through large-scale genetic/genomic and multi-omics data, including 1) revealing the genetic architecture of complex traits and common diseases using advanced genome-wide association study (GWAS)-based quantitative genetics methods; and 2) identifying potential relationships between disease risk and cellular genotypes/pathways using single-cell RNA sequence/spatial transcriptomics data and technology.

Qualifications

  • Doctor of Philosophy, Qld. UT

Publications

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Supervision

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision

Publications

Journal Article

  • Gough, Madeline, Liu, Cheng, Srinivasan, Bhuvana, Wilkinson, Lisa, Dunk, Louisa, Yang, Yuanhao, Schreiber, Veronika, Tuffaha, Haitham, Kryza, Thomas, Hooper, John D., Lakhani, Sunil R. and Snell, Cameron E. (2023). Improved concordance of challenging human epidermal growth factor receptor 2 dual in-situ hybridisation cases with the use of a digital image analysis algorithm in breast cancer. Histopathology, 83 (4), 647-656. doi: 10.1111/his.15000

  • Lin, Xin, Yang, Yuanhao, Gresle, Melissa, Cuellar-Partida, Gabriel, Han, Xikun, Stankovich, Jim, Fuh-Ngwa, Valery, Charlesworth, Jac, Burdon, Kathryn P, Butzkueven, Helmut, Taylor, Bruce V, Zhou, Yuan and AusLong/Ausimmune Investigators Group Steve Simpson-Yap (2023). Novel plasma and brain proteins that are implicated in multiple sclerosis. Brain, 146 (6) awac420, 2464-2475. doi: 10.1093/brain/awac420

  • Yap, Chloe X., Henders, Anjali K., Alvares, Gail A., Giles, Corey, Huynh, Kevin, Nguyen, Anh, Wallace, Leanne, McLaren, Tiana, Yang, Yuanhao, Hernandez, Leanna M., Gandal, Michael J., Hansell, Narelle K., Cleary, Dominique, Grove, Rachel, Hafekost, Claire, Harun, Alexis, Holdsworth, Helen, Jellett, Rachel, Khan, Feroza, Lawson, Lauren P., Leslie, Jodie, Levis Frenk, Mira, Masi, Anne, Mathew, Nisha E., Muniandy, Melanie, Nothard, Michaela, Miller, Jessica L., Nunn, Lorelle, Strike, Lachlan T. ... The Busselton Health Study Investigators (2023). Interactions between the lipidome and genetic and environmental factors in autism. Nature Medicine, 29 (4), 936-949. doi: 10.1038/s41591-023-02271-1

  • Jiao, Bin, Li, Rihui, Zhou, Hui, Qing, Kunqiang, Liu, Hui, Pan, Hefu, Lei, Yanqin, Fu, Wenjin, Wang, Xiaoan, Xiao, Xuewen, Liu, Xixi, Yang, Qijie, Liao, Xinxin, Zhou, Yafang, Fang, Liangjuan, Dong, Yanbin, Yang, Yuanhao, Jiang, Haiyan, Huang, Sha and Shen, Lu (2023). Neural biomarker diagnosis and prediction to mild cognitive impairment and Alzheimer's disease using EEG technology. Alzheimer's Research and Therapy, 15 (1) 32, 32. doi: 10.1186/s13195-023-01181-1

  • Yang, Yuanhao, Zhou, Yuan, Nyholt, Dale R., Yap, Chloe X., Tannenberg, Rudolph K., Wang, Ying, Wu, Yang, Zhu, Zhihong, Taylor, Bruce V. and Gratten, Jacob (2023). The shared genetic landscape of blood cell traits and risk of neurological and psychiatric disorders. Cell Genomics, 3 (2) 100249, 100249. doi: 10.1016/j.xgen.2022.100249

  • Lin, Xin, Yang, Yuanhao, Fuh-Ngwa, Valery, Yin, Xianyong, Simpson-Yap, Steve, van der Mei, Ingrid, Broadley, Simon A, Ponsonby, Anne-Louise, Burdon, Kathryn P, Taylor, Bruce V, Zhou, Yuan and Ausimmune/ AusLong Investigators Group (2023). Genetically determined serum serine level has a novel causal effect on multiple sclerosis risk and predicts disability progression. Journal of Neurology, Neurosurgery and Psychiatry, 94 (7) jnnp-2022-330259, 1-6. doi: 10.1136/jnnp-2022-330259

  • Foo, Cheng Xiang, Bartlett, Stacey, Chew, Keng Yih, Ngo, Minh Dao, Bielefeldt-Ohmann, Helle, Jayakody Arachchige, Buddhika, Matthews, Benjamin, Reed, Sarah, Wang, Ran, Smith, Christian, Sweet, Matthew J., Burr, Lucy, Bisht, Kavita, Shatunova, Svetlana, Sinclair, Jane E., Parry, Rhys, Yang, Yuanhao, Lévesque, Jean-Pierre, Khromykh, Alexander, Rosenkilde, Mette Marie, Short, Kirsty R. and Ronacher, Katharina (2023). GPR183 antagonism reduces macrophage infiltration in influenza and SARS-CoV-2 infection. European Respiratory Journal, 61 (3) 2201306, 1-15. doi: 10.1183/13993003.01306-2022

  • Lu, Zhiya, Zhang, Haoyang, Yang, Yuanhao and Zhao, Huiying (2023). Sex differences of the shared genetic landscapes between type 2 diabetes and peripheral artery disease in East Asians and Europeans. Human Genetics, 142 (7), 965-980. doi: 10.1007/s00439-023-02573-x

  • Xiu, Xuehao, Zhang, Haoyang, Xue, Angli, Cooper, David N., Yan, Li, Yang, Yuedong, Yang, Yuanhao and Zhao, Huiying (2022). Genetic evidence for a causal relationship between type 2 diabetes and peripheral artery disease in both Europeans and East Asians. BMC Medicine, 20 (1) 300, 1-16. doi: 10.1186/s12916-022-02476-0

  • Lin, Xin, Yang, Yuanhao, Melton, Phillip E., Singh, Vikrant, Simpson-Yap, Steve, Burdon, Kathryn P., Taylor, Bruce V. and Zhou, Yuan (2022). Integrating Genetic Structural Variations and Whole-Genome Sequencing Into Clinical Neurology. Neurology: Genetics, 8 (4) e200005, 1-12. doi: 10.1212/NXG.0000000000200005

  • Sheng, Yong H., Davies, Julie M., Wang, Ran, Wong, Kuan Yau, Giri, Rabina, Yang, Yuanhao, Begun, Jakob, Florin, Timothy H., Hasnain, Sumaira Z. and McGuckin, Michael A. (2022). MUC1 mediated macrophage activation promotes colitis-associated colorectal cancer via activating the IL-6/STAT3 axis. Cellular and Molecular Gastroenterology and Hepatology, 14 (4), 789-811. doi: 10.1016/j.jcmgh.2022.06.010

  • Yang, Yuanhao, Musco, Hannah, Simpson-Yap, Steve, Zhu, Zhihong, Wang, Ying, Lin, Xin, Zhang, Jiawei, Taylor, Bruce, Gratten, Jacob and Zhou, Yuan (2021). Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases. Nature Communications, 12 (1) 5641, 5641. doi: 10.1038/s41467-021-25768-0

  • Zhang, Haoyang, Xiu, Xuehao, Xue, Angli, Yang, Yuedong, Yang, Yuanhao and Zhao, Huiying (2021). Mendelian randomization study reveals a population-specific putative causal effect of type 2 diabetes in risk of cataract. International Journal of Epidemiology, 50 (6), 2024-2037. doi: 10.1093/ije/dyab175

  • Yap, Chloe X., Alvares, Gail A., Henders, Anjali K., Lin, Tian, Wallace, Leanne, Farrelly, Alaina, McLaren, Tiana, Berry, Jolene, Vinkhuyzen, Anna A. E., Trzaskowski, Maciej, Zeng, Jian, Yang, Yuanhao, Cleary, Dominique, Grove, Rachel, Hafekost, Claire, Harun, Alexis, Holdsworth, Helen, Jellett, Rachel, Khan, Feroza, Lawson, Lauren, Leslie, Jodie, Levis Frenk, Mira, Masi, Anne, Mathew, Nisha E., Muniandy, Melanie, Nothard, Michaela, Visscher, Peter M., Dawson, Paul A., Dissanayake, Cheryl ... Gratten, Jacob (2021). Analysis of common genetic variation and rare CNVs in the Australian Autism Biobank. Molecular Autism, 12 (1) 12, 12. doi: 10.1186/s13229-020-00407-5

  • Yengo, Loic, Robinson, Matthew R., Keller, Matthew C., Kemper, Kathryn E., Yang, Yuanhao, Trzaskowski, Maciej, Gratten, Jacob, Turley, Patrick, Cesarini, David, Benjamin, Daniel J., Wray, Naomi R., Goddard, Michael E., Yang, Jian and Visscher, Peter M. (2018). Imprint of assortative mating on the human genome. Nature Human Behaviour, 2 (12), 948-954. doi: 10.1038/s41562-018-0476-3

  • Yang, Yuanhao, Zhao, Huiying, Boomsma, Dorret I., Ligthart, Lannie, Belin, Andrea C., Smith, George Davey, Esko, Tonu, Freilinger, Tobias M., Hansen, Thomas Folkmann, Ikram, M. Arfan, Kallela, Mikko, Kubisch, Christian, Paraskevi, Christofidou, Strachan, David P., Wessman, Maija, International Headache Genetics Consortium, van den Maagdenberg, Arn M. J. M., Terwindt, Gisela M. and Nyholt, Dale R. (2018). Molecular genetic overlap between migraine and major depressive disorder. European Journal of Human Genetics, 26 (8), 1202-1216. doi: 10.1038/s41431-018-0150-2

  • Zhao, Huiying, Nyholt, Dale R., Yang, Yuanhao, Wang, Jihua and Yang, Yuedong (2017). Improving the detection of pathways in genome-wide association studies by combined effects of SNPs from Linkage Disequilibrium blocks. Scientific Reports, 7 (1) 3512. doi: 10.1038/s41598-017-03826-2

  • Corfield, E. C., Yang, Y., Martin, N. G. and Nyholt, D. R. (2017). A continuum of genetic liability for minor and major depression. Translational Psychiatry, 7 (5) e1131, e1131-e1131. doi: 10.1038/tp.2017.99

  • Yang, Yuanhao, Zhao, Huiying, Heath, Andrew C., Madden, Pamela A. F., Martin, Nicholas G. and Nyholt, Dale R. (2016). Familial aggregation of migraine and depression: insights from a large Australian twin sample. Twin Research and Human Genetics, 19 (4), 312-321. doi: 10.1017/thg.2016.43

  • Yang, Yuanhao, Zhao, Huiying, Heath, Andrew C., Madden, Pamela A. F., Martin, Nicholas G. and Nyholt, Dale R. (2016). Shared genetic factors underlie migraine and depression. Twin Research and Human Genetics, 19 (4), 341-350. doi: 10.1017/thg.2016.46

  • Yang, Yuanhao, Ligthart, Lannie, Terwindt, Gisela M., Boomsma, Dorret I., Rodriguez-Acevedo, Astrid J. and Nyholt, Dale R. (2016). Genetic epidemiology of migraine and depression. Cephalalgia, 36 (7), 679-691. doi: 10.1177/0333102416638520

Conference Publication

PhD and MPhil Supervision

Current Supervision