The University of Queensland

Helix-constrained nociceptin peptides are potent agonists and antagonists of ORL-1 and nociception

Lohman, Rink-Jan, Harrison, Rosemary S., Ruiz-Gomez, Gloria, Hoang, Huy Ngoc, Shepherd, Nicholas E., Chow, Shiao, Hill, Timothy A., Madala, Praveen K. and Fairlie, David P. (2015). Helix-constrained nociceptin peptides are potent agonists and antagonists of ORL-1 and nociception. Nociceptin opioid. (pp. 1-55) edited by Gerald Litwack. Maryland Heights, MO, United States: Academic Press. doi: 10.1016/bs.vh.2014.10.001

Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesoderm

Wu, Zhixuan, Shen, Sophie, Mizikovsky, Dalia, Cao, Yuanzhao, Naval-Sanchez, Marina, Tan, Siew Zhuan, Alvarez, Yanina D., Sun, Yuliangzi, Chen, Xiaoli, Zhao, Qiongyi, Kim, Daniel, Yang, Pengyi, Hill, Timothy A., Jones, Alun, Fairlie, David P., Pébay, Alice, Hewitt, Alex W., Tam, Patrick P.L., White, Melanie D., Nefzger, Christian M. and Palpant, Nathan J. (2024). Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesoderm. Developmental Cell. doi: 10.1016/j.devcel.2024.01.019

Protease-activated receptor 2 attenuates doxorubicin-induced apoptosis in colon cancer cells

Shah, Himani, Hill, Timothy A., Lim, Junxian and Fairlie, David P. (2023). Protease-activated receptor 2 attenuates doxorubicin-induced apoptosis in colon cancer cells. Journal of Cell Communication and Signaling, 17 (4), 1-15. doi: 10.1007/s12079-023-00791-6

Wollamide cyclic hexapeptides synergize with established and new tuberculosis antibiotics in targeting Mycobacterium tuberculosis

Rollo, Rachel F., Mori, Giorgia, Hill, Timothy A., Hillemann, Doris, Niemann, Stefan, Homolka, Susanne, Fairlie, David P. and Blumenthal, Antje (2023). Wollamide cyclic hexapeptides synergize with established and new tuberculosis antibiotics in targeting Mycobacterium tuberculosis. Microbiology Spectrum, 11 (4). doi: 10.1128/spectrum.00465-23

Ras related protein Rab5a regulates complement C5a receptor trafficking, chemotaxis and chemokine secretion in human macrophages

Wu, Kai-Chen, Condon, Nicholas D., Hill, Timothy A., Reid, Robert C., Fairlie, David and Lim, Junxian (2023). Ras related protein Rab5a regulates complement C5a receptor trafficking, chemotaxis and chemokine secretion in human macrophages. Journal of Innate Immunity, 15 (1), 468-484. doi: 10.1159/000530012

Helical structure in cyclic peptides: effect of N-methyl amides versus esters

Wu, Chongyang, Hoang, Huy N., Hill, Timothy A., Lim, Junxian, Kok, W. Mei, Akondi, Kalyani, Liu, Ligong and Fairlie, David P. (2022). Helical structure in cyclic peptides: effect of N-methyl amides versus esters. Chemical Communications, 58 (89), 12475-12478. doi: 10.1039/d2cc05092g

Modifying a hydroxyl patch in glucagon-like peptide 1 produces biased agonists with unique signaling profiles

Wang, Peiqi, Hill, Timothy A., Mitchell, Justin, Fitzsimmons, Rebecca L., Xu, Weijun, Loh, Zhixuan, Suen, Jacky Y., Lim, Junxian, Iyer, Abishek and Fairlie, David P. (2022). Modifying a hydroxyl patch in glucagon-like peptide 1 produces biased agonists with unique signaling profiles. Journal of Medicinal Chemistry, 65 (17), 11759-11775. doi: 10.1021/acs.jmedchem.2c00653

De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex

Chen, Kai-En, Guo, Qian, Hill, Timothy A., Cui, Yi, Kendall, Amy K., Yang, Zhe, Hall, Ryan J., Healy, Michael D., Sacharz, Joanna, Norwood, Suzanne J., Fonseka, Sachini, Xie, Boyang, Reid, Robert C., Leneva, Natalya, Parton, Robert G., Ghai, Rajesh, Stroud, David A., Fairlie, David P, Suga, Hiroaki, Jackson, Lauren P., Teasdale, Rohan D., Passioura, Toby and Collins, Brett M. (2021). De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex. Science Advances, 7 (49) eabg4007, eabg4007. doi: 10.1126/sciadv.abg4007

Connecting hydrophobic surfaces in cyclic peptides increases membrane permeability

Hoang, Huy N., Hill, Timothy A. and Fairlie, David P. (2021). Connecting hydrophobic surfaces in cyclic peptides increases membrane permeability. Angewandte Chemie International Edition, 60 (15), 8385-8390. doi: 10.1002/anie.202012643

Systemic delivery of peptides by the oral route: formulation and medicinal chemistry approaches

Brayden, D. J., Hill, T. A., Fairlie, D. P., Maher, S. and Mrsny, R. J. (2020). Systemic delivery of peptides by the oral route: formulation and medicinal chemistry approaches. Advanced Drug Delivery Reviews, 157, 2-36. doi: 10.1016/j.addr.2020.05.007

Correction: Twists or turns: stabilising alpha vs. beta turns in tetrapeptides

Hoang, Huy N., Hill, Timothy A., Ruiz-Gómez, Gloria, Diness, Frederik, Mason, Jody M., Wu, Chongyang, Abbenante, Giovanni, Shepherd, Nicholas E. and Fairlie, David P. (2020). Correction: Twists or turns: stabilising alpha vs. beta turns in tetrapeptides. Chemical Science, 11 (28), 7511-7511. doi: 10.1039/d0sc90138e

High cell permeability does not predict oral bioavailability for analogues of cyclic heptapeptide sanguinamide A

Nielsen, Daniel S., Lohman, Rink-Jan, Hoang, Huy N., Fairlie, David P. and Hill, Timothy A. (2020). High cell permeability does not predict oral bioavailability for analogues of cyclic heptapeptide sanguinamide A. Australian Journal of Chemistry, 73 (4), 344-351. doi: 10.1071/ch19479

A novel long‐range n to π* interaction secures the smallest known α‐helix in water

Hoang, Huy N., Wu, Chongyang, Hill, Timothy A., Dantas de Araujo, Aline, Bernhardt, Paul V., Liu, Ligong and Fairlie, David P. (2019). A novel long‐range n to π* interaction secures the smallest known α‐helix in water. Angewandte Chemie, 131 (52), 19049-19053. doi: 10.1002/ange.201911277

A novel long-range n to π* interaction secures the smallest known α-helix in water

Hoang, Huy N., Wu, Chongyang, Hill, Timothy A., Dantas de Araujo, Aline, Bernhardt, Paul V., Liu, Ligong and Fairlie, David P. (2019). A novel long-range n to π* interaction secures the smallest known α-helix in water. Angewandte Chemie International Edition, 58 (52) ange.201911277, 18873-18877. doi: 10.1002/anie.201911277

Mirror image pairs of cyclic hexapeptides have different oral bioavailabilities and metabolic stabilities

Lohman, Rink-Jan, Nielsen, Daniel S., Kok, W. Mei, Hoang, Huy N., Hill, Timothy A. and Fairlie, David P. (2019). Mirror image pairs of cyclic hexapeptides have different oral bioavailabilities and metabolic stabilities. Chemical Communications, 55 (89), 13362-13365. doi: 10.1039/c9cc06234c

Crystal structures of protein-bound cyclic peptides

Malde, Alpeshkumar K., Hill, Timothy A., Iyer, Abishek and Fairlie, David P. (2019). Crystal structures of protein-bound cyclic peptides. Chemical Reviews, 119 (17) acs.chemrev.8b00807, 9861-9914. doi: 10.1021/acs.chemrev.8b00807

Structure-activity relationships of wollamide cyclic hexapeptides with activity against drug-resistant and intracellular

Khalil, Zeinab G., Hill, Timothy A., De Leon Rodriguez, Luis M., Lohman, Rink-Jan, Hoang, Huy N., Reiling, Norbert, Hillemann, Doris, Brimble, Margaret A., Fairlie, David, Blumenthal, Antje and Capon, Robert J. (2019). Structure-activity relationships of wollamide cyclic hexapeptides with activity against drug-resistant and intracellular. Antimicrobial Agents and Chemotherapy, 63 (3) e01773-18. doi: 10.1128/AAC.01773-18

Twists or turns: stabilising alpha vs. beta turns in tetrapeptides

Hoang, Huy N., Hill, Timothy A., Ruiz-Gómez, Gloria, Diness, Frederik, Mason, Jody M., Wu, Chongyang, Abbenante, Giovanni, Shepherd, Nicholas E. and Fairlie, David P. (2019). Twists or turns: stabilising alpha vs. beta turns in tetrapeptides. Chemical Science, 10 (45), 10595-10600. doi: 10.1039/c9sc04153b

Contiguous hydrophobic and charged surface patches in short helix-constrained peptides drive cell permeability

Perry, Samuel R, Hill, Timothy A, de Araujo, Aline D, Hoang, Huy N and Fairlie, David P (2018). Contiguous hydrophobic and charged surface patches in short helix-constrained peptides drive cell permeability. Organic & biomolecular chemistry, 16 (3), 367-371. doi: 10.1039/c7ob02952g

Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun

Baxter, Daniel, Perry, Samuel R., Hill, Timothy A., Kok, W. Mei, Zaccai, Nathan R., Brady, R. Leo, Fairlie, David P. and Mason, Jody M. (2017). Downsizing proto-oncogene cFos to short helix-constrained peptides that bind Jun. ACS Chemical Biology, 12 (8), 2051-2061. doi: 10.1021/acschembio.7b00303

Biased signaling by agonists of protease activated receptor 2

Jiang, Yuhong, Yau, Mei-Kwan, Kok, W. Mei, Lim, Junxian, Wu, Kai-Chen, Liu, Ligong, Hill, Timothy A., Suen, Jacky Y. and Fairlie, David P. (2017). Biased signaling by agonists of protease activated receptor 2. ACS Chemical Biology, 12 (5), 1217-1226. doi: 10.1021/acschembio.6b01088

Alpha helix nucleation by a simple cyclic tetrapeptide

Hoang, Huy N., Wu, Chongyang, Beyer, Renee L., Hill, Timothy A. and Fairlie, David P. (2017). Alpha helix nucleation by a simple cyclic tetrapeptide. Australian Journal of Chemistry, 70 (2), 213-219. doi: 10.1071/CH16591

Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling

Plisson, Fabien, Hill, Timothy A., Mitchell, Justin M., Hoang, Huy N., de Araujo, Aline D., Xu, Weijun, Cotterell, Adam, Edmonds, David J., Stanton, Robert V., Derksen, David R., Loria, Paula M., Griffith, David A., Price, David A., Liras, Spiros and Fairlie, David P. (2017). Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling. European Journal of Medicinal Chemistry, 127, 703-714. doi: 10.1016/j.ejmech.2016.10.044

Pyrimidine-Based Inhibitors of Dynamin I GTPase Activity: Competitive Inhibition at the Pleckstrin Homology Domain

Odell, Luke R., Abdel-Hamid, Mohammed K., Hill, Timothy A., Ngoc Chau, , Young, Kelly A., Deane, Fiona M., Sakoff, Jennette A., Andersson, Sofia, Daniel, James A., Robinson, Phillip J. and McCluskey, Adam (2017). Pyrimidine-Based Inhibitors of Dynamin I GTPase Activity: Competitive Inhibition at the Pleckstrin Homology Domain. Journal of Medicinal Chemistry, 60 (1), 349-361. doi: 10.1021/acs.jmedchem.6b01422

Helix nucleation by the smallest known α-helix in water

Hoang, Huy N., Driver, Russell W., Beyer, Renee L., Hill, Timothy A., de Araujo, Aline D., Plisson, Fabien, Harrison, Rosemary S., Goedecke, Lena, Shepherd, Nicholas E. and Fairlie, David P. (2016). Helix nucleation by the smallest known α-helix in water. Angewandte Chemie (International Edition), 55 (29), 8275-8279. doi: 10.1002/anie.201602079

Flexibility versus rigidity for orally bioavailable cyclic hexapeptides

Nielsen, Daniel S., Lohman, Rink-Jan, Hoang, Huy Ngoc, Hill, Timothy A., Jones, Alun, Lucke, Andrew J. and Fairlie, David P. (2015). Flexibility versus rigidity for orally bioavailable cyclic hexapeptides. Chembiochem, 16 (16), 2289-2293. doi: 10.1002/cbic.201500441

Short hydrophobic peptides with cyclic constraints are potent glucagon-like peptide-1 receptor (GLP-1R) agonists

Hoang, Huy N., Song, Kun, Hill, Timothy A., Derksen, David R., Edmonds, David J., Kok, W. Mei, Limberakis, Chris, Liras, Spiros, Loria, Paula M., Mascitti, Vincent, Mathiowetz, Alan M., Mitchell, Justin M., Piotrowski, David W., Price, David A., Stanton, Robert V., Suen, Jacky Y., Withka, Jane M., Griffith, David A. and Fairlie, David P. (2015). Short hydrophobic peptides with cyclic constraints are potent glucagon-like peptide-1 receptor (GLP-1R) agonists. Journal of Medicinal Chemistry, 58 (9), 4080-4085. doi: 10.1021/acs.jmedchem.5b00166

Improving on nature: making a cyclic heptapeptide orally bioavailable

Nielsen, Daniel S., Hoang, Huy N., Lohman, Rink-Jan, Hill, Timothy A., Lucke, Andrew J., Craik, David J., Edmonds, David J., Griffith, David A., Rotter, Charles J., Ruggeri, Roger B., Price, David A., Liras, Spiros and Fairlie, David P. (2014). Improving on nature: making a cyclic heptapeptide orally bioavailable. Angewandte Chemie - International Edition, 53 (45), 12059-12063. doi: 10.1002/anie.201405364

Helical cyclic pentapeptides constrain HIV-1 Rev peptide for enhanced RNA binding

Harrison, Rosemary S., Shepherd, Nicholas E., Hoang, Huy N., Beyer, Renee L., Ruiz-Gomez, Gloria, Kelso, Michael J., Mei Kok, W., Hill, Timothy A., Abbenante, Giovanni and Fairlie, David P. (2014). Helical cyclic pentapeptides constrain HIV-1 Rev peptide for enhanced RNA binding. Tetrahedron, 70 (42), 7645-7650. doi: 10.1016/j.tet.2014.07.096

Cyclic penta- and hexaleucine peptides without N-methylation are orally absorbed

Hill, Timothy A., Lohman, Rink-Jan, Hoang, Huy N., Nielsen, Daniel S., Scully, Conor C. G., Kok, W. Mei, Liu, Ligong, Lucke, Andrew J., Stoermer, Martin J., Schroeder, Christina I., Chaousis, Stephanie, Colless, Barbara, Bernhardt, Paul V., Edmonds, David J., Griffith, David A., Rotter, Charles J., Ruggeri, Roger B., Price, David A., Liras, Spiros, Craik, David J. and Fairlie, David P. (2014). Cyclic penta- and hexaleucine peptides without N-methylation are orally absorbed. ACS Medicinal Chemistry Letters, 5 (10), 1148-1151. doi: 10.1021/ml5002823

Constraining cyclic peptides to mimic protein structure motifs

Hill, Timothy A., Shepherd, Nicholas E., Diness, Frederik and Fairlie, David P. (2014). Constraining cyclic peptides to mimic protein structure motifs. Angewandte Chemie (International Edition), 53 (48), 13020-13041. doi: 10.1002/anie.201401058

Fixierung cyclischer Peptide: Mimetika von Proteinstrukturmotiven

Hill, Timothy A., Shepherd, Nicholas E., Diness, Frederik and Fairlie, David P. (2014). Fixierung cyclischer Peptide: Mimetika von Proteinstrukturmotiven. Angewandte Chemie, 126 (48), 13234-13257. doi: 10.1002/ange.201401058

Comparative α-Helicity of Cyclic Pentapeptides in Water

de Araujo, Aline D., Hoang, Huy N., Kok, W. Mei, Diness, Frederik, Gupta, Praveer, Hill, Timothy A., Driver, Russell W., Price, David A., Liras, Spiros and Fairlie, David P. (2014). Comparative α-Helicity of Cyclic Pentapeptides in Water. Angewandte Chemie International Edition, 53 (27), 6965-6969. doi: 10.1002/anie.201310245/abstract

A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells

Stehn, Justine R., Haass, Nikolas K., Bonello, Teresa, Desouza, Melissa, Kottyan, Gregg, Treutlein, Herbert, Zeng, Jun, Nascimento, Paula R. B. B., Sequeira, Vanessa B., Butler, Tanya L., Allanson, Munif, Fath, Thomas, Hill, Timothy A., McCluskey, Adam, Schevzov, Galina, Palmer, Stephen J., Hardeman, Edna C., Winlaw, David, Reeve, Vivienne E., Dixon, Ian, Weninger, Wolfgang, Cripe, Timothy P. and Gunning, Peter W. (2013). A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells. Cancer Research, 73 (16), 5169-5182. doi: 10.1158/0008-5472.CAN-12-4501

Pyrimidyn compounds: dual-action small molecule pyrimidine-based dynamin inhibitors

McGeachie, Andrew B., Odell, Luke R., Quan, Annie, Daniel, James A., Chau, Ngoc, Hill, Timothy A., Gorgani, Nick N., Keating, Damien J., Cousin, Michael A., van Dam, Ellen M., Mariana, Anna, Whiting, Ainslie, Perera, Swetha, Novelle, Aimee, Young, Kelly A., Deane, Fiona M., Gilbert, Jayne, Sakoff, Jennette A., Chircop, Megan, McCluskey, Adam and Robinson, Phillip J. (2013). Pyrimidyn compounds: dual-action small molecule pyrimidine-based dynamin inhibitors. ACS Chemical Biology, 8 (7), 1507-1518. doi: 10.1021/cb400137p

Truncated and Helix-Constrained Peptides with High Affinity and Specificity for the cFos Coiled-Coil of AP-1

Rao, Tara, Ruiz-Gomez, Gloria, Hill, Timothy A., Hoang, Huy N., Fairlie, David P. and Mason, Jody M. (2013). Truncated and Helix-Constrained Peptides with High Affinity and Specificity for the cFos Coiled-Coil of AP-1. PLoS One, 8 (3) e59415, e59415.1-e59415.12. doi: 10.1371/journal.pone.0059415

Folding pentapeptides into left and right handed alpha helices

Hoang, Huy N., Abbenante, Giovanni, Hill, Timothy A., Ruiz-Gomez, Gloria and Fairlie, David P. (2012). Folding pentapeptides into left and right handed alpha helices. Tetrahedron, 68 (23), 4513-4516. doi: 10.1016/j.tet.2011.10.108

An Ugi-intramolecular Diels-Alder route to highly substituted tetrahydroepoxyisoindole carboxamides

Gordon, Christopher P., Young, Kelly A., Robertson, Mark J., Hill, Timothy A. and McCluskey, Adam (2011). An Ugi-intramolecular Diels-Alder route to highly substituted tetrahydroepoxyisoindole carboxamides. Tetrahedron, 67 (2), 554-561. doi: 10.1016/j.tet.2010.10.042

Novel helix-constrained nociceptin derivatives are potent agonists and antagonists of ERK phosphorylation and thermal analgesia in mice

Harrison, Rosemary S., Ruiz-Gomez, Gloria, Hill, Timothy A., Chow, Shiao Y., Shepherd, Nicholas E., Lohman, Rink-Jan, Abbenante, Giovanni, Hoang, Huy N. and Fairlie, David P. (2010). Novel helix-constrained nociceptin derivatives are potent agonists and antagonists of ERK phosphorylation and thermal analgesia in mice. Journal of Medicinal Chemistry, 53 (23), 8400-8408. doi: 10.1021/jm101139f

The antiplasmodial activity of norcantharidin analogs

Bajsa, Joanna, McCluskey, Adam, Gordon, Christopher P., Stewart, Scott G., Hill, Timothy A., Sahu, Rajnish, Duke, Stephen O. and Tekwani, Babu L. (2010). The antiplasmodial activity of norcantharidin analogs. Bioorganic and Medicinal Chemistry Letters, 20 (22), 6688-6695. doi: 10.1016/j.bmcl.2010.09.004

Update 1 of: Beta-strand mimetics

Loughlin, Wendy A., Tyndall, Joel D. A., Glenn, Matthew P., Hill, Timothy A. and Fairlie, David P. (2010). Update 1 of: Beta-strand mimetics. Chemical Reviews, 110 (6), 1-38. doi: 10.1021/cr900395y

Update 1 of: beta-strand mimetics

Loughlin, Wendy A., Tyndall, Joel D. A., Glenn, Matthew P., Hill, Timothy A. and Fairlie, David P. (2010). Update 1 of: beta-strand mimetics. Chemical Reviews, 110 (6), PR32-PR69. doi: 10.1021/cr040648k

Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency

Harrison, Rosemary S., Shepherd, Nicholas E., Hoang, Huy N., Ruiz-Goméz, Gloria, Hill, Timothy A., Driver, Russell W., Desai, Vishal S., Young, Paul R., Abbenante, Giovanni and Fairlie, David P. (2010). Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency. Proceedings of the National Academy of Sciences of the United States of America, 107 (26), 11686-11691. doi: 10.1073/pnas.1002498107

Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis

Hill, Timothy A., Mariana, Anna, Gordon, Christopher P., Odell, Luke R., Robertson, Mark J., McGeachie, Andrew B., Chau, Ngoc, Daniel, James A., Gorgani, Nick N., Robinson, Phillip J. and McCluskey, Adam (2010). Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis. Journal of Medicinal Chemistry, 53 (10), 4094-4102. doi: 10.1021/jm100119c

Inhibition of dynamin mediated endocytosis by the Dynoles - synthesis and functional activity of a family of indoles

Hill, Timothy A., Gordon, Christopher P., McGeachie, Andrew B., Venn-Brown, Barbara, Odell, Luke R., Chau, Ngoc, Quan, Annie, Mariana, Anna, Sakoff, Jennette A., Chircop (nee Fabbro), Megan, Robinson, Phillip J. and McCluskey, Adam (2009). Inhibition of dynamin mediated endocytosis by the Dynoles - synthesis and functional activity of a family of indoles. Journal of Medicinal Chemistry, 52 (12), 3762-3773. doi: 10.1021/jm900036m

Norcantharidin analogues: Synthesis, anticancer activity and protein phosphatase 1 and 2A inhibition

Hill, Timothy A., Stewart, Scott G., Gordon, Christopher P., Ackland, Stephen P., Gilbert, Jayne, Sauer, Benjamin, Sakoff, Jennette A. and McCluskey, Adam (2008). Norcantharidin analogues: Synthesis, anticancer activity and protein phosphatase 1 and 2A inhibition. ChemMedChem, 3 (12), 1878-1892. doi: 10.1002/cmdc.200800192

Synthesis and biological evaluation of norcantharidin analogues: Towards PP1 selectivity

Stewart, Scott G., Hill, Timothy A., Gilbert, Jayne, Ackland, Stephen P., Sakoff, Jennette A. and McCluskey, Adam (2007). Synthesis and biological evaluation of norcantharidin analogues: Towards PP1 selectivity. Bioorganic & Medicinal Chemistry, 15 (23), 7301-7310. doi: 10.1016/j.bmc.2007.08.028

Norcantharimides, synthesis and anticancer activity: Synthesis of new norcantharidin analogues and their anticancer evaluation

Hill, Timothy A., Stewart, Scott G., Ackland, Stephen P., Gilbert, Jayne, Sauer, Benjamin, Sakoff, Jennette and McCluskey, Adam (2007). Norcantharimides, synthesis and anticancer activity: Synthesis of new norcantharidin analogues and their anticancer evaluation. Bioorganic & Medicinal Chemistry, 15 (18), 6126-6134. doi: 10.1016/j.bmc.2007.06.034

Heterocyclic substituted cantharidin and norcantharidin analogues—synthesis, protein phosphatase (1 and 2A) inhibition, and anti-cancer activity

Hill, Timothy A., Stewart, Scott G., Sauer, Benjamin, Gilbert, Jayne, Ackland, Stephen P., Sakoff, Jennette A. and McCluskey, Adam (2007). Heterocyclic substituted cantharidin and norcantharidin analogues—synthesis, protein phosphatase (1 and 2A) inhibition, and anti-cancer activity. Bioorganic & Medicinal Chemistry Letters, 17 (12), 3392-3397. doi: 10.1016/j.bmcl.2007.03.093

Small molecule inhibitors of dynamin I GTPase activity: Development of dimeric tyrphostins

Hill, Timothy, Odell, Luke R., Edwards, Jennifer K., Graham, Mark E., McGeachie, Andrew B., Rusak, Jenny, Quan, Annie, Abagyan, Ruben, Scott, Janet L., Robinson, Phillip J. and McCluskey, Adam (2005). Small molecule inhibitors of dynamin I GTPase activity: Development of dimeric tyrphostins. Journal of Medicinal Chemistry, 48 (24), 7781-7788. doi: 10.1021/jm040208l

BiCl3-mediated opening of epoxides, a facile route to chlorohydrins or amino alcohols: One reagent, two paths

McCluskey, Adam, Leitch, Sarah K., Garner, James, Caden, Christine E., Hill, Timothy A., Odell, Luke R. and Stewart, Scott G. (2005). BiCl3-mediated opening of epoxides, a facile route to chlorohydrins or amino alcohols: One reagent, two paths. Tetrahedron Letters, 46 (47), 8229-8232. doi: 10.1016/j.tetlet.2005.09.088

Parallel solution-phase synthesis of targeted tyrphostin libraries with anticancer activity

Hill, Timothy A., Sakoff, Jennette A., Robinson, Phillip J. and McCluskey, Adam (2005). Parallel solution-phase synthesis of targeted tyrphostin libraries with anticancer activity. Australian Journal of Chemistry, 58 (2), 94-103. doi: 10.1071/CH04143

Identification of aminopyrimidine regioisomers via line broadening effects in 1H and 13C NMR spectroscopy

Garner, James, Hill, Tim, Odell, Luke, Keller, Paul, Morgan, Jody and McCluskey, Adam (2004). Identification of aminopyrimidine regioisomers via line broadening effects in 1H and 13C NMR spectroscopy. Australian Journal of Chemistry, 57 (11), 1079-1083. doi: 10.1071/CH03316

Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity

Hill, Timothy A., Odell, Luke R., Quan, Annie, Abagyan, Ruben, Ferguson, Gemma, Robinson, Phillip J. and McCluskey, Adam (2004). Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity. Bioorganic & Medicinal Chemistry Letters, 14 (12), 3275-3278. doi: 10.1016/j.bmcl.2004.03.096

Green chemistry approaches to the Knoevenagel condensation: Comparison of ethanol, water and solvent free (dry grind) approaches

McCluskey, A, Robinson, PJ, Hill, T, Scott, JL and Edwards, JK (2002). Green chemistry approaches to the Knoevenagel condensation: Comparison of ethanol, water and solvent free (dry grind) approaches. Tetrahedron Letters, 43 (17), 3117-3120. doi: 10.1016/S0040-4039(02)00480-X

Cyclic penta- and hexa leucine peptides without N-methylation are orally absorbed

Kok, Woan Mei, Hill, Timothy A., Lohman, Rink-Jan, Hoang, Huy N., Nielsen, Daniel S., Scully, Conor G., Schroeder, Christina I., Colless, Barbara, Bernhardt, Paul V., Edmonds, David, Griffith, David, Rotter, Charles, Ruggeri, Roger, Price, David, Liras, Spiros, Craik, David and Fairlie, David (2015). Cyclic penta- and hexa leucine peptides without N-methylation are orally absorbed. American Chemical Society Meeting, x, 2015. Washington, DC United States: American Chemical Society.

Developing chemotherapeutics which selectively disable the actin cytoskeleton of tumor cells

Stehn, J. R., Haass, N. K., Bonello, T., Desouza, M., Kottyan, G., Treutlein, H., Zeng, J., Nascimento, P. R., Butler, T., Allanson, M., Fath, T., Hill, T. A., McCluskey, A., Schevzov, G., Palmer, S., Hardeman, E. C., Winlaw, D., Reeve, V. E., Dixon, I., Weninger, W., Cripe, T. P. and Gunning, P. (2012). Developing chemotherapeutics which selectively disable the actin cytoskeleton of tumor cells. 39th Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF), Marburg Germany, Mar 01-03, 2012. WILEY-BLACKWELL.