Journal Article: Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction
Leinenga, Gerhard, To, Xuan Vinh, Bodea, Liviu-Gabriel, Yousef, Jumana, Richter-Stretton, Gina, Palliyaguru, Tishila, Chicoteau, Antony, Dagley, Laura, Nasrallah, Fatima and Götz, Jürgen (2024). Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction. Molecular Psychiatry, 1-16. doi: 10.1038/s41380-024-02509-5
Other Outputs: Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction
Leinenga, Gerhard, To, Xuan Vinh, Bodea, Liviu-Gabriel, Youse, Jumana, Richter-Stretton, Gina, Palliyaguru, Tishila, Chicoteau, Antony, Dagley, Laura, Nasrallah, Fatima and Götz, Jürgen (2023). Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction.
Journal Article: Transcriptional signature in microglia isolated from an Alzheimer's disease mouse model treated with scanning ultrasound
Leinenga, Gerhard, Bodea, Liviu‐Gabriel, Schröder, Jan, Sun, Giuzhi, Zhou, Yichen, Song, Jae, Grubman, Alexandra, Polo, Jose M. and Götz, Jürgen (2022). Transcriptional signature in microglia isolated from an Alzheimer's disease mouse model treated with scanning ultrasound. Bioengineering & Translational Medicine, 8 (1) e10329, e10329. doi: 10.1002/btm2.10329
In vitro microscopy studies into the organization and dynamics of key proteins that form the blood-brain barrier in physiological and pathological ageing and in response to therapeutic ultrasound
Doctor Philosophy
Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction
Leinenga, Gerhard, To, Xuan Vinh, Bodea, Liviu-Gabriel, Yousef, Jumana, Richter-Stretton, Gina, Palliyaguru, Tishila, Chicoteau, Antony, Dagley, Laura, Nasrallah, Fatima and Götz, Jürgen (2024). Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction. Molecular Psychiatry, 1-16. doi: 10.1038/s41380-024-02509-5
Leinenga, Gerhard, Bodea, Liviu‐Gabriel, Schröder, Jan, Sun, Giuzhi, Zhou, Yichen, Song, Jae, Grubman, Alexandra, Polo, Jose M. and Götz, Jürgen (2022). Transcriptional signature in microglia isolated from an Alzheimer's disease mouse model treated with scanning ultrasound. Bioengineering & Translational Medicine, 8 (1) e10329, e10329. doi: 10.1002/btm2.10329
Wasielewska, Joanna M., Chaves, Juliana C.S., Johnston, Rebecca L., Milton, Laura A., Hernández, Damián, Chen, Liyu, Song, Jae, Lee, Wendy, Leinenga, Gerhard, Nisbet, Rebecca M., Pébay, Alice, Götz, Jürgen, White, Anthony R. and Oikari, Lotta E. (2022). A sporadic Alzheimer’s blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies. Theranostics, 12 (16), 6826-6847. doi: 10.7150/thno.72685
Chen, Liyu, Sutharsan, Ratneswary, Lee, Jonathan LF, Cruz, Esteban, Asnicar, Blaise, Palliyaguru, Tishila, Wasielewska, Joanna M, Gaudin, Arnaud, Song, Jae, Leinenga, Gerhard and Götz, Jürgen (2022). Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model. Theranostics, 12 (5), 1952-1970. doi: 10.7150/thno.65539
Leinenga, Gerhard, Koh, Wee Kiat and Götz, Jürgen (2021). A comparative study of the effects of Aducanumab and scanning ultrasound on amyloid plaques and behavior in the APP23 mouse model of Alzheimer disease. Alzheimer's Research and Therapy, 13 (1) 76, 1-14. doi: 10.1186/s13195-021-00809-4
Delivery of antibodies into the brain using focused scanning ultrasound
Leinenga, Gerhard, Bodea, Liviu-Gabriel, Koh, Wee Kiat, Nisbet, Rebecca M. and Götz, Jürgen (2020). Delivery of antibodies into the brain using focused scanning ultrasound. Journal of Visualized Experiments, 2020 (161) e61372, 1-13. doi: 10.3791/61372
Leinenga, Gerhard, Koh, Wee Kiat and Götz, Jürgen (2019). Scanning ultrasound in the absence of blood-brain barrier opening is not sufficient to clear β-amyloid plaques in the APP23 mouse model of Alzheimer's disease. Brain Research Bulletin, 153, 8-14. doi: 10.1016/j.brainresbull.2019.08.002
Janowicz, Phillip W., Leinenga, Gerhard, Götz, Jürgen and Nisbet, Rebecca M. (2019). Ultrasound-mediated blood-brain barrier opening enhances delivery of therapeutically relevant formats of a tau-specific antibody. Scientific Reports, 9 (1) 9255, 9255. doi: 10.1038/s41598-019-45577-2
Pandit, Rucha, Leinenga, Gerhard and Gotz, Jurgen (2019). Repeated ultrasound treatment of tau transgenic mice clears neuronal tau by autophagy and improves behavioral functions. Theranostics, 9 (13), 3754-3767. doi: 10.7150/thno.34388
Modeling ultrasound propagation through material of increasing geometrical complexity
Odabaee, Maryam, Odabaee, Mostafa, Pelekanos, Matthew, Leinenga, Gerhard and Götz, Jürgen (2018). Modeling ultrasound propagation through material of increasing geometrical complexity. Ultrasonics, 90, 52-62. doi: 10.1016/j.ultras.2018.05.014
Safety and Efficacy of Scanning Ultrasound Treatment of Aged APP23 Mice
Leinenga, Gerhard and Gotz, Jurgen (2018). Safety and Efficacy of Scanning Ultrasound Treatment of Aged APP23 Mice. Frontiers in Neuroscience, 12 (FEB) 55, 1-10. doi: 10.3389/fnins.2018.00055
Pelekanos, Matthew, Leinenga, Gerhard, Odabaee, Mostafa, Odabaee, Maryam, Saifzadeh, Siamak, Steck, Roland and Götz, Jürgen (2018). Establishing sheep as an experimental species to validate ultrasound-mediated blood-brain barrier opening for potential therapeutic interventions. Theranostics, 8 (9), 2583-2602. doi: 10.7150/thno.22852
Ultrasound as a treatment modality for neurological diseases
Leinenga, Gerhard, Nisbet, Rebecca M. and Gotz, Jurgen (2017). Ultrasound as a treatment modality for neurological diseases. Medical Journal of Australia, 206 (11), 470-471. doi: 10.5694/mja16.01013
Nisbet, Rebecca M., Van der Jeugd, Ann, Leinenga, Gerhard, Evans, Harrison T., Janowicz, Phillip W. and Goetz, Juergen (2017). Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model. Brain, 140 (5), 1220-1230. doi: 10.1093/brain/awx052
Hatch, Robert John, Leinenga, Gerhard and Götz, Jürgen (2016). Scanning ultrasound (SUS) causes no changes to neuronal excitability and prevents age-related reductions in hippocampal CA1 dendritic structure in wild-type mice. PloS One, 11 (10) e0164278, e0164278. doi: 10.1371/journal.pone.0164278
Ultrasound treatment of neurological diseases — current and emerging applications
Leinenga, Gerhard, Langton, Christian, Nisbet, Rebecca and Gotz, Jurgen (2016). Ultrasound treatment of neurological diseases — current and emerging applications. Nature Reviews Neurology, 12 (3), 161-174. doi: 10.1038/nrneurol.2016.13
Scanning ultrasound removes amyloid-beta and restores memory in an Alzheimer's disease mouse model
Leinenga, Gerhard and Götz, Jürgen (2015). Scanning ultrasound removes amyloid-beta and restores memory in an Alzheimer's disease mouse model. Science Translational Medicine, 7 (278), 278ra33.1-278ra33.12. doi: 10.1126/scitranslmed.aaa2512
Goetz, Juergen, Xia, Di, Leinenga, Gerhard, Chew, Yee Lian and Nicholas, Hannah R. (2013). What renders TAU toxic. Frontiers in Neurology, 4 Article 72, 72.1-72.10. doi: 10.3389/fneur.2013.00072
Scanning Focused Ultrasound disruption of the blood-brain barrier as an Alzheimer’s disease therapy
Leinenga, Gerhard, Nisbet, Rebecca, Hatch, Robert, Van der Jeugd, Anneke, Evans, Harrison and Götz, Jürgen (2016). Scanning Focused Ultrasound disruption of the blood-brain barrier as an Alzheimer’s disease therapy. 5th International Symposium on Focused Ultrasound, Bethesda, MD United States, 28 August - 1 September 2016. London, United Kingdom: BioMed Central. doi: 10.1186/s40349-016-0076-5
Scanning ultrasound as a treatment tool of proteinopathies including Alzheimer’s disease
Götz, Jürgen, Nisbet, Rebecca, Van der Jeugd, Ann, Evans, Harrison and Leinenga, Gerhard (2016). Scanning ultrasound as a treatment tool of proteinopathies including Alzheimer’s disease. 5th International Symposium on Focused Ultrasound, Bethesda, MD, USA, 28 August - 1 September 2016. London, United Kingdom: BioMed Central. doi: 10.1186/s40349-016-0076-5
Effects of scanning focused ultrasound in an Alzheimer's mouse model
Leinenga, G. and Goetz, J. (2015). Effects of scanning focused ultrasound in an Alzheimer's mouse model. 25th Biennial Meeting of the International Society for Neurochemistry jointly with the 13th Meeting of the Asian‐Pacific Society for Neurochemistry in conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD, Australia, 23 - 27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing.
Novel strategies to target tau and Ab toxicity
Goetz, J., Nisbet, R., Leinenga, G. and Van der Jeugd, A. (2015). Novel strategies to target tau and Ab toxicity. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom Publisher: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13186
Van der Jeugd, A., Leinenga, G., Nisbet, R. and Goetz, J. (2015). Scanning ultrasound opens blood-brain barrier and improves pathologic abnormalities and behaviour in a mouse model of Alzheimer's. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, QLD, Australia, 23 - 27 August 2015. West Sussex, United Kingdom: Wiley-Blackwell Publishing.
Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction
Leinenga, Gerhard, To, Xuan Vinh, Bodea, Liviu-Gabriel, Youse, Jumana, Richter-Stretton, Gina, Palliyaguru, Tishila, Chicoteau, Antony, Dagley, Laura, Nasrallah, Fatima and Götz, Jürgen (2023). Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction.
Investigations of the effects of scanning focused ultrasound in mouse models of Alzheimer’s disease
Leinenga, Gerhard (2017). Investigations of the effects of scanning focused ultrasound in mouse models of Alzheimer’s disease. PhD Thesis, Queensland Brain Institute, The University of Queensland. doi: 10.14264/uql.2017.467
In vitro microscopy studies into the organization and dynamics of key proteins that form the blood-brain barrier in physiological and pathological ageing and in response to therapeutic ultrasound
Doctor Philosophy — Associate Advisor
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