Dr Abdullah Tarique

Postdoctoral Research Fellow

Institute for Molecular Bioscience

Overview

Research Interests

  • Innate Immune Responses of Macrophages in Cystic Fibrosis (CF)
    Understanding the impaired immune responses of CF macrophages at cellular and molecular level.

Qualifications

  • Doctor of Philosophy, The University of Queensland
  • Masters (Research), Erasmus University of Rotterdam
  • Masters (Research) of Science, University of Dhaka
  • Bachelor (Honours) of Science (Advanced), University of Dhaka

Publications

View all Publications

Available Projects

  • CF macrophages and monocytes (the precursor cells of macrophages) were functionally defective in CF in many aspects due to mutation(s) in CFTR gene. Inavailability of patient's specimen is scarce which creates a bar in CF macrophage research. This project aims to create a CFTR-KO human monocytic cell line using CRISPR-Cas9 technology. We anticipate that this CFTR-KO cell line will provide unlimited supply of CFTR-KO macrophages for research. The project will suit to honors students with strong interest in cell and molecular biology. Basic laboratory knowledge including cell culture, real-time PCR, western blot would be helpful.

  • Bacteria killing ability of CF macrophages are known to be defective to extracellular bacteria. There is limited knowledge that how CF macrophages fight against intracellular bacteria. M. abscessus (MABS), an intracellular organism, is increasingly found in the CF lungs. Using MABS as a model pathogen, we aim to investigate how CF macrophages are defective in killing and clearance of intracellular bacteria and whether MABS killing ability can be enhanced by treating CF macrophages with a range of potential therapeutic agents. Basic laboratory knowledge including cell culture, bacterial culture, real-time PCR, western blot would be helpful.

  • Mitochondria play crucial roles in killing and clearance of intracellular pathogens. Defective mitochondrial responses to respiratory bacteria had previously been observed in CFTR-KO zebrafish model and epithelial cells. This project aims to

    • understand how CFTR mutation(s) downregulate mitochondrial responses in macrophages obtained from CF patients,
    • test a number of potential therapeutic agents whether they could improve mitochondrial defence mechanism in CF macrophages.

View all Available Projects

Publications

Book Chapter

  • Elahi, C. M. F., Seraj, Z. I., Rasul, N. M., Tarique, A. A., Das, K. C., Biswas, K., Salam, M. A., Gomosta, A. R., Tumimbang, E., Adorada, D., Gregori, G. and Bennett, J. (2004). Breeding rice for salinity tolerance using the Pokkali allele: Finding a linked DNA marker. In vitro culture transformation and molecular markers for crop improvement. (pp. 157-170) edited by A. S. Islam. Boca Raton, FL, United States: CRC Press.

Journal Article

Conference Publication

  • Morshed, M., Tarique, A., Sly, P., Bell, S., Wainwright, C. and Fantino, E. (2019). Kinetic expression of genes and receptors during monocyte to macrophage differentiation in cystic fibrosis. TSANZSRS 2019 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting, Gold Coast, Australia, 29 March–2 April 2019. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.13492

  • Wainwright, C., Tarique, A., Sly, P., Bell, S. and Fantino, E. (2019). Modulation of macrophage polarization and function in patients with cystic fibrosis by mutation-independent immunomodulatory compounds. TSANZSRS 2019 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting, Gold Coast, Australia, 29 March–2 April 2019. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/resp.13492

  • Tarique, Abdullah A. (2018). Macrophages - the forgotten cells in cystic fibrosis. The 32nd Annual North American Cystic Fibrosis Conference, Denver, Colorado, United States, October 18–20, 2018. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/ppul.24151

  • Tarique, Abdullah, Sly, Peter, Holt, Patrick, Bosco, Anthony, Ware, Robert, Logan, Jayden, Bell, Scott, Wainwright, Claire and Fantino, Emmanuelle (2016). CFTR-dependent deficiency in alternatively-activated macrophages in cystic fibrosis. ERS Lung Science Conference 2016, Estoril, Portugal, 10 - 13 March 2016. Sheffield, United Kingdom: European Respiratory Society. doi: 10.1183/13993003.congress-2016.PA4856

Other Outputs

PhD and MPhil Supervision

Completed Supervision

Possible Research Projects

Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.

  • CF macrophages and monocytes (the precursor cells of macrophages) were functionally defective in CF in many aspects due to mutation(s) in CFTR gene. Inavailability of patient's specimen is scarce which creates a bar in CF macrophage research. This project aims to create a CFTR-KO human monocytic cell line using CRISPR-Cas9 technology. We anticipate that this CFTR-KO cell line will provide unlimited supply of CFTR-KO macrophages for research. The project will suit to honors students with strong interest in cell and molecular biology. Basic laboratory knowledge including cell culture, real-time PCR, western blot would be helpful.

  • Bacteria killing ability of CF macrophages are known to be defective to extracellular bacteria. There is limited knowledge that how CF macrophages fight against intracellular bacteria. M. abscessus (MABS), an intracellular organism, is increasingly found in the CF lungs. Using MABS as a model pathogen, we aim to investigate how CF macrophages are defective in killing and clearance of intracellular bacteria and whether MABS killing ability can be enhanced by treating CF macrophages with a range of potential therapeutic agents. Basic laboratory knowledge including cell culture, bacterial culture, real-time PCR, western blot would be helpful.

  • Mitochondria play crucial roles in killing and clearance of intracellular pathogens. Defective mitochondrial responses to respiratory bacteria had previously been observed in CFTR-KO zebrafish model and epithelial cells. This project aims to

    • understand how CFTR mutation(s) downregulate mitochondrial responses in macrophages obtained from CF patients,
    • test a number of potential therapeutic agents whether they could improve mitochondrial defence mechanism in CF macrophages.