Dr Karnaker Reddy Tupally

Honorary Lecturer

School of Pharmacy
Faculty of Health and Behavioural Sciences


Karnaker's research interests are natural products, peptide-based drug discovery and development, formulation chemistry and non-viral gene delivery system. Karnaker co-inventor and developed a novel, bioresponsive disulphide-linker technology, which has been used for non-viral vectors, peptide-therapeutics for pain and cancer treatment. Karnaker is also keen interest for topical, mucosal drug delivery using a range of dendrimer, nano and microbubbles, lipid and polymer-based nanoparticle systems in conjugation with both biological and physical stimuli-responsiveness.

Karnaker received a PhD in Pharmaceutical Chemistry from The University Queensland under the supervision of Dr Harendra Parekh and Dr Defang Ouyang. Prior to PhD, he completed a Master degree in Pharmaceutical Analysis and Quality assurance (India). Also worked as analytical research and development chemist for one year in a Pharma company. Since 2016, he his working with Dr Parekh team on a range of Industry-funded research projects and his role involves from ideation, research plan, execution, product delivery to industry partners on major platforms such as peptide-based therapeutics, gene therapy and sol-gel technology.

Research Interests

  • Non-viral gene delivery
    Bioresponsive peptide & Lipid-based nanoparticle for delivering gene-therapeutics

Research Impacts

Karnaker is co-inventor for several patents (PCT, provisional stage) from Dr Parekh and Team, licensed to industry partners which received million dollars in funding for further research and development


  • Doctor of Philosophy, The University of Queensland
  • Master of Pharmacy (Pharmaceutical Analysis & QA), Jawaharlal Nehru Technological University
  • Bachelor of Pharmacy, Kakatiya University


View all Publications


  • Doctor Philosophy

  • Doctor Philosophy

  • Doctor Philosophy

View all Supervision



  • Singh, Prachi, Kokil, Ganesh R., Tupally, Karnaker R., Poddar, Kingshuk, Tan, Aaron, Venkatesan, Venky, Parekh, Harendra S. and Pastorin, Giorgia (2016). Therapeutic perspectives in Type-1 Diabetes. Singapore: Springer. doi: 10.1007/978-981-10-0602-9

Book Chapter

  • Singh, Prachi, Kokil, Ganesh R., Tupally, Karnaker R., Poddar, Kingshuk, Tan, Aaron, Venkatesan, Venky, Parekh, Harendra S. and Pastorin, Giorgia (2016). Introduction to diabetes and type 1 diabetes. Therapeutic perspectives in type-1 diabetes. (pp. 1-6) edited by Prachi Singh, Ganesh R. Kokil, Karnaker R. Tupally, Kingshuk Poddar, Aaron Tan, Venky Venkatesan, Harendra S. Parekh and Giorgia Pastorin. Singapore, Singapore: Springer. doi: 10.1007/978-981-10-0602-9_1

  • Tupally, Karnaker R., Kokil, Ganesh K., Thakur, Sachin S., Singh, Prachi and Parekh, Harendra S. (2015). Dendrimers. Controlled release systems: advances in nanobottles and active nanoparticles. (pp. 259-286) edited by Alexander van Herk, Jacqueline Forcada and Giorgia Pastorin. Boca Raton, FL, United States: Taylor & Francis. doi: 10.1201/b19860-15

  • Seefeld, Anne, Kokil, Ganesh R., Tupally, Karnaker R., Parekh, Harendra S. and Herten, Dirk-Peter (2013). Fluorescent nucleic acid probes in living cells. DNA and RNA nanobiotechnologies in medicine: diagnosis and treatment of diseases. (pp. 291-328) edited by Volker A. Erdmann and Jan Barciszewski. Berlin, Germany: Springer. doi: 10.1007/978-3-642-36853-0_12

Journal Article

Conference Publication

PhD and MPhil Supervision

Current Supervision

Completed Supervision