Journal Article: White matter microstructure is associated with the precision of visual working memory
Li, Xuqian, Rangelov, Dragan, Mattingley, Jason B., Oestreich, Lena, Lévy-Bencheton, Delphine and O'Sullivan, Michael J. (2023). White matter microstructure is associated with the precision of visual working memory. NeuroImage, 272 120069, 1-11. doi: 10.1016/j.neuroimage.2023.120069
Journal Article: Hyperconnectivity and altered interactions of a nucleus accumbens network in post-stroke depression
Oestreich, Lena K L, Wright, Paul and O’Sullivan, Michael J (2022). Hyperconnectivity and altered interactions of a nucleus accumbens network in post-stroke depression. Brain Communications, 4 (6) fcac281, 1-13. doi: 10.1093/braincomms/fcac281
Journal Article: Texture features of magnetic resonance images predict poststroke cognitive impairment: validation in a multicenter study
Betrouni, Nacim, Jiang, Jiyang, Duering, Marco, Georgakis, Marios K., Oestreich, Lena, Sachdev, Perminder S., O’Sullivan, Michael, Wright, Paul, Lo, Jessica W., Bordet, Régis and on behalf of the Stroke and Cognition (STROKOG) Collaboration (2022). Texture features of magnetic resonance images predict poststroke cognitive impairment: validation in a multicenter study. Stroke, 53 (11), 101161STROKEAHA122039732-3454. doi: 10.1161/strokeaha.122.039732
Post-stroke depression: vulnerability, mechanisms and novel treatment targets
(2022–2026) NHMRC Investigator Grants
(2022) The Cass Foundation Limited
International Brain Research Organization International Travel Grant
(2020–2021) IBRO International Travel Grant
Structure-function brain network dynamics in post-stroke depression
Doctor Philosophy
Structural and effective neural networks in schizotypy: in light of auditory prediction errors
(2018) Master Philosophy
Various projects using the UK biobank neuroimaging data
The UK Biobank is a large-scale biomedical database and research resource, containing in-depth neuroimaging, genetic and health information from half a million UK participants.
Multiple projects are available for students interested to work on large neuroimaging datasets. Methods used in our group include, but are not limited to, diffusion MRI, connectomics, resting-state fMRI, machine learning, structure-function coupling and sympotm-comorbidity mapping using graph theroetical approaches. Our main focus is inspired by the goal to develop a better understanding of brain-based mechanisms and associated risk factors that lead to the development and maintenance of mental disorders and neuropsychiatric consequence of brain injury or other neurological conditions. Students interested in healthy brain strucutre and function are also welcome to apply.
White matter microstructure is associated with the precision of visual working memory
Li, Xuqian, Rangelov, Dragan, Mattingley, Jason B., Oestreich, Lena, Lévy-Bencheton, Delphine and O'Sullivan, Michael J. (2023). White matter microstructure is associated with the precision of visual working memory. NeuroImage, 272 120069, 1-11. doi: 10.1016/j.neuroimage.2023.120069
Hyperconnectivity and altered interactions of a nucleus accumbens network in post-stroke depression
Oestreich, Lena K L, Wright, Paul and O’Sullivan, Michael J (2022). Hyperconnectivity and altered interactions of a nucleus accumbens network in post-stroke depression. Brain Communications, 4 (6) fcac281, 1-13. doi: 10.1093/braincomms/fcac281
Betrouni, Nacim, Jiang, Jiyang, Duering, Marco, Georgakis, Marios K., Oestreich, Lena, Sachdev, Perminder S., O’Sullivan, Michael, Wright, Paul, Lo, Jessica W., Bordet, Régis and on behalf of the Stroke and Cognition (STROKOG) Collaboration (2022). Texture features of magnetic resonance images predict poststroke cognitive impairment: validation in a multicenter study. Stroke, 53 (11), 101161STROKEAHA122039732-3454. doi: 10.1161/strokeaha.122.039732
Cholinergic and hippocampal systems facilitate cross-domain cognitive recovery after stroke
O’Sullivan, Michael J., Oestreich, Lena K. L., Wright, Paul and Clarkson, Andrew N. (2022). Cholinergic and hippocampal systems facilitate cross-domain cognitive recovery after stroke. Brain, 145 (5), 1698-1710. doi: 10.1093/brain/awac070
Ziaei, Maryam, Oestreich, Lena, Persson, Jonas, Reutens, David C. and Ebner, Natalie C. (2022). Neural correlates of affective empathy in aging: A multimodal imaging and multivariate approach: Abbreviated title: Multimodal and multivariate approach to empathy. Aging, Neuropsychology, and Cognition, 29 (3), 577-598. doi: 10.1080/13825585.2022.2036684
Transdiagnostic in vivo magnetic resonance imaging markers of neuroinflammation
Oestreich, Lena KL. and O’Sullivan, Michael J. (2022). Transdiagnostic in vivo magnetic resonance imaging markers of neuroinflammation. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 7 (7), 638-658. doi: 10.1016/j.bpsc.2022.01.003
Age-related differences in negative cognitive empathy but similarities in positive affective empathy
Ziaei, Maryam, Oestreich, Lena, Reutens, David C. and Ebner, Natalie C. (2021). Age-related differences in negative cognitive empathy but similarities in positive affective empathy. Brain Structure and Function, 226 (6), 1823-1840. doi: 10.1007/s00429-021-02291-y
Microstructural changes in the reward system are associated with post-stroke depression
Oestreich, Lena K. L., Wright, Paul and O'Sullivan, Michael J. (2020). Microstructural changes in the reward system are associated with post-stroke depression. NeuroImage: Clinical, 28 102360, 102360. doi: 10.1016/j.nicl.2020.102360
Dzafic, Ilvana, Oestreich, Lena, Martin, Andrew K., Mowry, Bryan and Burianová, Hana (2019). Cover image. Human Brain Mapping, 40 (18). doi: 10.1002/hbm.24301
Oestreich, L. K. L., Randeniya, R. and Garrido, M. I. (2019). Auditory prediction errors and auditory white matter microstructure associated with psychotic-like experiences in healthy individuals. Brain Structure and Function, 224 (9), 3277-3289. doi: 10.1007/s00429-019-01972-z
Dzafic, Ilvana, Oestreich, Lena, Martin, Andrew K., Mowry, Bryan and Burianová, Hana (2019). Stria terminalis, amygdala, and temporoparietal junction networks facilitate efficient emotion processing under expectations. Human Brain Mapping, 40 (18) hbm.24779, 5382-5396. doi: 10.1002/hbm.24779
Oestreich, Lena K. L., Randeniya, Roshini and Garrido, Marta I. (2019). Auditory white matter pathways are associated with effective connectivity of auditory prediction errors within a fronto-temporal network. NeuroImage, 195, 454-462. doi: 10.1016/j.neuroimage.2019.04.008
White matter connectivity reductions in the pre-clinical continuum of psychosis: a connectome study
Oestreich, Lena K. L., Randeniya, Roshini and Garrido, Marta I. (2019). White matter connectivity reductions in the pre-clinical continuum of psychosis: a connectome study. Human Brain Mapping, 40 (2), 529-537. doi: 10.1002/hbm.24392
Prediction of speech sounds is facilitated by a functional fronto-temporal network
Oestreich, Lena K. L., Whitford, Thomas J. and Garrido, Marta (2018). Prediction of speech sounds is facilitated by a functional fronto-temporal network. Frontiers in Neural Circuits, 12 43, 43. doi: 10.3389/fncir.2018.00043
Whitford, Thomas J., Oestreich, Lena K. L., Ford, Judith M., Roach, Brian J., Loewy, Rachel L., Stuart, Barbara K. and Mathalon, Daniel H. (2017). Deficits in cortical suppression during vocalization are associated with structural abnormalities in the arcuate fasciculus in early illness schizophrenia and clinical high risk for psychosis. Schizophrenia Bulletin, 44 (6), 1312-1322. doi: 10.1093/schbul/sbx144
Kelly, S., Jahanshad, N., Zalesky, A., Kochunov, P., Agartz, I., Alloza, C., Andreassen, O. A., Arango, C., Banaj, N., Bouix, S., Bousman, C. A., Brouwer, R. M., Bruggemann, J., Bustillo, J, Cahn, W., Calhoun, V., Cannon, D., Carr, V., Catts, S., Chen, J., Chen, J.-X., Chen, X., Chiapponi, C., Cho, K. l. K., Ciullo, V., Corvin, A. S., Crespo-Facorro, B., Cropley, V., De Rossi, P. ... Donohoe, G. (2017). Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group. Molecular Psychiatry, 23 (5), 1261-1269. doi: 10.1038/mp.2017.170
McCarthy-Jones, Simon, Oestreich, Lena K. L., Lyall, Amanda E., Kikinis, Zora, Newell, Dominik T., Savadjiev, Peter, Shenton, Martha E., Kubicki, Martha E., Pasternak, Ofer, Whitfordm Thomas J. and Australian Schizophrenia Research Bank (2017). Childhood adversity associated with white matter alteration in the corpus callosum, corona radiata, and uncinate fasciculus of psychiatrically healthy adults. Brain Imaging and Behavior, 12 (2), 1-10. doi: 10.1007/s11682-017-9703-1
Characterizing white matter changes in chronic schizophrenia: a free-water imaging multi-site study
Oestreich, Lena K. L., Lyall, Amanda E., Pasternak, Ofer, Kikinis, Zora, Newell, Dominick T. , Savadjiev, Peter, Bouix, Sylvain, Shenton, Martha E., Kubicki, Marek, Whitford, Thomas J. and McCarthy-Jones, Simon (2017). Characterizing white matter changes in chronic schizophrenia: a free-water imaging multi-site study. Schizophrenia Research, 189, 153-161. doi: 10.1016/j.schres.2017.02.006
Sensory prediction errors in the continuum of psychosis
Randeniya, R., Oestreich, L. K. L. and Garrido, M. I. (2017). Sensory prediction errors in the continuum of psychosis. Schizophrenia Research, 191, 109-122. doi: 10.1016/j.schres.2017.04.019
Oestreich, Lena K. L., Pasternak, Ofer, Shenton, Martha E., Kubicki, Marek, Gong, Xue, Australian Schizophrenia Research Bank, McCarthy-Jones, Simon and Whitford, Thomas J. (2016). Abnormal white matter microstructure and increased extracellular free-water in the cingulum bundle associated with delusions in chronic schizophrenia. NeuroImage: Clinical, 12, 405-414. doi: 10.1016/j.nicl.2016.08.004
Oestreich, Lena K. L., McCarthy-Jones, Simon and Whitford, Thomas J. (2016). Decreased integrity of the fronto-temporal fibers of the left inferior occipito-frontal fasciculus associated with auditory verbal hallucinations in schizophrenia. Brain Imaging and Behavior, 10 (2), 445-454. doi: 10.1007/s11682-015-9421-5
Mifsud, Nathan G., Oestreich, Lena K. L., Jack, Bradley N., Ford, Judith M., Roach, Brian J., Mathalon, Daniel H. and Whitford, Thomas J. (2016). Self-initiated actions result in suppressed auditory but amplified visual evoked components in healthy participants. Psychophysiology, 53 (5), 723-732. doi: 10.1111/psyp.12605
Cortical suppression to delayed self-initiated auditory stimuli in schizotypy
Oestreich, Lena K. L., Mifsud, Nathan G., Ford, Judith M., Roach, Brian J., Mathalon, Daniel H. and Whitford, Thomas J. (2016). Cortical suppression to delayed self-initiated auditory stimuli in schizotypy. Clinical EEG and Neuroscience, 47 (1), 3-10. doi: 10.1177/1550059415581708
Oestreich, Lena K. L., Mifsud, Nathan G., Ford, Judith M., Roach, Brian J., Mathalon, Daniel H. and Whitford, Thomas J. (2015). Subnormal sensory attenuation to self-generated speech in schizotypy: Electrophysiological evidence for a 'continuum of psychosis'. International Journal of Psychophysiology, 97 (2), 131-138. doi: 10.1016/j.ijpsycho.2015.05.014
McCarthy-Jones, Simon, Oestreich, Lena K. L. and Whitford, Thomas J. (2015). Reduced integrity of the left arcuate fasciculus is specifically associated with auditory verbal hallucinations in schizophrenia. Schizophrenia Research, 162 (1-3), 1-6. doi: 10.1016/j.schres.2014.12.041
Aberrant brain dynamics and structure associated with post-stroke depression
Oestreich, L. K. L., Wright, P. and O'Sullivan, M. J. (2021). Aberrant brain dynamics and structure associated with post-stroke depression. Stroke Society of Australasia Annual Scientific Meeting, Perth, WA Australia, 13–15 October 2021. London, United Kingdom: SAGE Publications.
Towards the development of neuroimaging biomarkers for post-stroke depression
Oestreich, Lena, Wright, Paul, Williams, Steven and O'Sullivan, Michael (2019). Towards the development of neuroimaging biomarkers for post-stroke depression. SSA 2019 Conference, Canberra, Australia, 10 – 13 September 2019. London, United Kingdom: Sage Publications. doi: 10.1177/1747493019862960
Oestreich, Lena, Mifsud, Nathan, Roach, Brian, Mathalon, Daniel, Ford, Judith and Whitford, Thomas (2015). Sensory attenuation to self-generated speech in highly schizotypal individuals: psychophysiological evidence for a 'continuum of psychosis'. 15th International Congress on Schizophrenia Research (ICOSR), Colorado Springs, CO United States, 28 March - 1 April 2015. Oxford, United Kingdom: Oxford University Press.
Post-stroke depression: vulnerability, mechanisms and novel treatment targets
(2022–2026) NHMRC Investigator Grants
(2022) The Cass Foundation Limited
International Brain Research Organization International Travel Grant
(2020–2021) IBRO International Travel Grant
Effective and structural brain networks underlying statistical learning.
(2017) Ian Potter Foundation
Structure-function brain network dynamics in post-stroke depression
Doctor Philosophy — Principal Advisor
Other advisors:
Structural and effective neural networks in schizotypy: in light of auditory prediction errors
(2018) Master Philosophy — Associate Advisor
Note for students: The possible research projects listed on this page may not be comprehensive or up to date. Always feel free to contact the staff for more information, and also with your own research ideas.
Various projects using the UK biobank neuroimaging data
The UK Biobank is a large-scale biomedical database and research resource, containing in-depth neuroimaging, genetic and health information from half a million UK participants.
Multiple projects are available for students interested to work on large neuroimaging datasets. Methods used in our group include, but are not limited to, diffusion MRI, connectomics, resting-state fMRI, machine learning, structure-function coupling and sympotm-comorbidity mapping using graph theroetical approaches. Our main focus is inspired by the goal to develop a better understanding of brain-based mechanisms and associated risk factors that lead to the development and maintenance of mental disorders and neuropsychiatric consequence of brain injury or other neurological conditions. Students interested in healthy brain strucutre and function are also welcome to apply.