The University of Queensland

Scalable and efficient In planta biosynthesis of sunflower trypsin inhibitor-1 (SFTI) peptide therapeutics

Handley, Thomas N. G., Jackson, Mark A. and Craik, David J. (2022). Scalable and efficient In planta biosynthesis of sunflower trypsin inhibitor-1 (SFTI) peptide therapeutics. Peptide macrocycles: methods and protocols. (pp. 117-142) edited by Matthew B. Coppock and Alexander J. Winton. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-1689-5_7

Cyclotides in a biotechnological context: opportunities and challenges

Jackson, Mark A. and Gilding, Edward K. (2015). Cyclotides in a biotechnological context: opportunities and challenges. Plant cyclotides. (pp. 305-333) edited by David J. Craik. Amsterdam, Netherlands: Academic Press. doi: 10.1016/bs.abr.2015.09.010

Nematicidal activity of cyclotides: toxicity against​​​​​​​ Caenorhabditis elegans

Bajpai, Abhishek, Jackson, Mark A., Huang, Yen-Hua, Yap, Kuok, Du, Qingdan, Chau, Tevin Chui-Ying, Craik, David J. and Gilding, Edward K. (2023). Nematicidal activity of cyclotides: toxicity against​​​​​​​ Caenorhabditis elegans. Journal of Natural Products, 86 (5), 1222-1229. doi: 10.1021/acs.jnatprod.2c01124

Plant-based production of an orally active cyclotide for the treatment of multiple sclerosis

Jackson, Mark A., Xie, Jing, Nguyen, Linh T. T., Wang, Xiaohan, Yap, Kuok, Harvey, Peta J., Gilding, Edward K. and Craik, David J. (2023). Plant-based production of an orally active cyclotide for the treatment of multiple sclerosis. Transgenic Research, 32 (1-2), 121-133. doi: 10.1007/s11248-023-00341-1

Rational domestication of a plant-based recombinant expression system expands its biosynthetic range

Jackson, Mark A., Chan, Lai Yue , Harding, Maxim D., Craik, David J. and Gilding, Edward K. (2022). Rational domestication of a plant-based recombinant expression system expands its biosynthetic range. Journal of Experimental Botany, 73 (18), 6103-6114. doi: 10.1093/jxb/erac273

Comparative analysis of cyclotide-producing plant cell suspensions presents opportunities for cyclotide plant molecular farming

Doffek, Benjamin, Huang, Yvonne, Huang, Yen-Hua, Chan, Lai Yue, Gilding, Edward K., Jackson, Mark A. and Craik, David J. (2022). Comparative analysis of cyclotide-producing plant cell suspensions presents opportunities for cyclotide plant molecular farming. Phytochemistry, 195 113053, 113053. doi: 10.1016/j.phytochem.2021.113053

Make it or break it: plant AEPs on stage in biotechnology

Jackson, Mark A., Nguyen, Linh T. T., Gilding, Edward K., Durek, Thomas and Craik, David J. (2020). Make it or break it: plant AEPs on stage in biotechnology. Biotechnology Advances, 45 107651, 107651. doi: 10.1016/j.biotechadv.2020.107651

Production of a structurally validated cyclotide in rice suspension cells is enabled by a supporting biosynthetic enzyme

Qu, Haiou, Jackson, Mark A., Yap, Kuok, Harvey, Peta J., Gilding, Edward K. and Craik, David J. (2020). Production of a structurally validated cyclotide in rice suspension cells is enabled by a supporting biosynthetic enzyme. Planta, 252 (6) 97, 97. doi: 10.1007/s00425-020-03505-z

Insecticidal diversity of butterfly pea (Clitoria ternatea) accessions

Oguis, Georgianna K., Gilding, Edward K., Huang, Yen-Hua, Poth, Aaron G., Jackson, Mark A. and Craik, David J. (2020). Insecticidal diversity of butterfly pea (Clitoria ternatea) accessions. Industrial Crops and Products, 147 112214, 112214. doi: 10.1016/j.indcrop.2020.112214

Circular permutation of the native enzyme-mediated cyclization position in cyclotides

Smithies, Bronwyn J., Huang, Yen-Hua, Jackson, Mark A., Yap, Kuok, Gilding, Edward K., Harris, Karen S., Anderson, Marilyn A. and Craik, David J. (2020). Circular permutation of the native enzyme-mediated cyclization position in cyclotides. ACS Chemical Biology, 15 (4) acschembio.9b00996, 962-969. doi: 10.1021/acschembio.9b00996

A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein

Harris, Karen S., Guarino, Rosemary F., Dissanayake, Ravindu S., Quimbar, Pedro, McCorkelle, Owen C., Poon, Simon, Kaas, Quentin, Durek, Thomas, Gilding, Edward K., Jackson, Mark A., Craik, David J., van der Weerden, Nicole L., Anders, Robin F. and Anderson, Marilyn A. (2019). A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein. Scientific Reports, 9 (1) 10820, 10820. doi: 10.1038/s41598-019-47273-7

Butterfly pea (Clitoria ternatea), a cyclotide-bearing plant with applications in agriculture and medicine

Oguis, Georgianna K., Gilding, Edward K., Jackson, Mark A. and Craik, David J. (2019). Butterfly pea (Clitoria ternatea), a cyclotide-bearing plant with applications in agriculture and medicine. Frontiers in Plant Science, 10 645, 645. doi: 10.3389/fpls.2019.00645

Rapid and scalable plant-based production of a potent plasmin inhibitor peptide

Jackson, Mark A., Yap, Kuok, Poth, Aaron G., Gilding, Edward K., Swedberg, Joakim E., Poon, Simon, Qu, Haiou, Durek, Thomas, Harris, Karen, Anderson, Marilyn A. and Craik, David J. (2019). Rapid and scalable plant-based production of a potent plasmin inhibitor peptide. Frontiers in Plant Science, 10 602, 602. doi: 10.3389/fpls.2019.00602

Papain-like cysteine proteases prepare plant cyclic peptide precursors for cyclization

Rehm, Fabian B. H., Jackson, Mark A., De Geyter, Ewout, Yap, Kuok, Gilding, Edward K., Durek, Thomas and Craik, David J. (2019). Papain-like cysteine proteases prepare plant cyclic peptide precursors for cyclization. Proceedings of the National Academy of Sciences, 116 (16), 7831-7836. doi: 10.1073/pnas.1901807116

Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases

Jackson, M. A., Gilding, E. K., Shafee, T., Harris, K. S., Kaas, Q., Poon, S., Yap, K., Jia, H., Guarino, R., Chan, L. Y., Durek, T., Anderson, M. A. and Craik, D. J. (2018). Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases. Nature Communications, 9 (1) 2411, 2411. doi: 10.1038/s41467-018-04669-9

Co-expression of a cyclizing asparaginyl endopeptidase enables efficient production of cyclic peptides in planta

Poon, Simon, Harris, Karen S, Jackson, Mark A, McCorkelle, Owen C, Gilding, Edward K, Durek, Thomas, van der Weerden, Nicole L, Craik, David J and Anderson, Marilyn A (2017). Co-expression of a cyclizing asparaginyl endopeptidase enables efficient production of cyclic peptides in planta. Journal of experimental botany, 69 (3), 633-641. doi: 10.1093/jxb/erx422

Gene coevolution and regulation lock cyclic plant defence peptides to their targets

Gilding, Edward K., Jackson, Mark A., Poth, Aaron G., Henriques, Sonia Troeira, Prentis, Peter J., Mahatmanto, Tunjung and Craik, David J. (2015). Gene coevolution and regulation lock cyclic plant defence peptides to their targets. New Phytologist, 210 (2), 717-730. doi: 10.1111/nph.13789

Design rules for efficient transgene expression in plants

Jackson M.A., Sternes, Peter R., Mudge, Stephen R., Graham, Michael W. and Birch, Robert G. (2014). Design rules for efficient transgene expression in plants. Plant Biotechnology Journal, 12 (7), 925-933. doi: 10.1111/pbi.12197

Comparison of Agrobacterium and particle bombardment using whole plasmid or minimal cassette for production of high-expressing, low-copy transgenic plants

Jackson, Mark A., Anderson, David J. and Birch, Robert G. (2013). Comparison of Agrobacterium and particle bombardment using whole plasmid or minimal cassette for production of high-expressing, low-copy transgenic plants. Transgenic Research, 22 (1), 143-151. doi: 10.1007/s11248-012-9639-6

A soluble acid invertase is directed to the vacuole by a signal anchor mechanism

Rae, Anne L., Casu, Rosanne E., Perroux, Jai M., Jackson, Mark A. and Grof, Christopher P. L. (2011). A soluble acid invertase is directed to the vacuole by a signal anchor mechanism. Journal of Plant Physiology, 168 (9), 983-989. doi: 10.1016/j.jplph.2010.11.003

Comparative efficiency of subcellular targeting signals for expression of a toxic protein in sugarcane

Jackson, Mark A., Nutt, Kerry A., Hassall, Rachael and Rae, Anne L. (2010). Comparative efficiency of subcellular targeting signals for expression of a toxic protein in sugarcane. Functional Plant Biology, 37 (8), 785-793. doi: 10.1071/FP09243

Functional specialization of vacuoles in sugarcane leaf and stem

Rae, Anne, L., Jackson, Mark A., Nguyen, Chau H. and Bonnett, Graham D. (2009). Functional specialization of vacuoles in sugarcane leaf and stem. Tropical Plant Biology, 2 (1), 13-22. doi: 10.1007/s12042-008-9019-9

A bioinformatic approach to the identification of a conserved domain in a sugarcane legumain that directs GFP to the lytic vacuole

Jackson, M. A., Rae, A. L., Casu, R. E., Grof, C. P. L., Bonnett, G. D. and Maclean, D. J. (2007). A bioinformatic approach to the identification of a conserved domain in a sugarcane legumain that directs GFP to the lytic vacuole. Functional Plant Biology, 34 (7), 633-644. doi: 10.1071/FP07024

The identification and characterisation of alleles of sucrose phosphate synthase gene family III in sugarcane

McIntyre, C. L., Jackson, M., Cordeiro, G. M., Amouyal, O., Hermann, S., Aitken, K. S., Eliott, F., Henry, R. J., Casu, R. E. and Bonnett, G. D. (2006). The identification and characterisation of alleles of sucrose phosphate synthase gene family III in sugarcane. Molecular Breeding, 18 (1), 39-50. doi: 10.1007/s11032-006-9012-7

Design and plant-based production of therapeutic cyclic peptides

Craik, D., Oguis, G. K., Smithies, B., Qu, H., Gilding, E. K. and Jackson, M. A. (2016). Design and plant-based production of therapeutic cyclic peptides. 34th European Peptide Symposium, Leipzig, Germany, 4‐9 September 2016. Oxford, United Kingdom: John Wiley & Sons.

Identification and Functional Testing of Peptide Targeting Sequences for Vacuolar Compartmentation in Sugarcane

Jackson, Mark (2009). Identification and Functional Testing of Peptide Targeting Sequences for Vacuolar Compartmentation in Sugarcane. PhD Thesis, School of Biological Sciences, The University of Queensland.