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Profiling the pro- and anti-inflammatory functions of histone deacetylases in macrophages (2008–2009)

Abstract:
HDAC inhibitors are anti-cancer drugs that kill rapidly growing cells (like cancer cells). These drugs are also beneficial in inflammatory diseases such as Rheumatoid Arthritis and sepsis (infections of the blood). However, it is unknown how they reduce inflammation. In this project we aim to understand how HDAC inhibitors act as anti-inflammatory agents and to design new HDAC inhibitors with reduced side effects for the treatment of inflammatory diseases.
Grant type:
Cancer Council Queensland
Researchers:

  • Professor Matt Sweet

    NHMRC Leadership Fellow - GL
    Institute for Molecular Bioscience
    Affiliate NHMRC Leadership Fellow
    School of Chemistry and Molecular Biosciences
    Faculty of Science

  • Professor David Fairlie

    NHMRC Leadership Fellow and Group L
    Institute for Molecular Bioscience
    NHMRC Leadership Fellow and Group L
    Institute for Molecular Bioscience
    Affiliate of ARC COE for Innovation
    ARC Centre of Excellence for Innovations in Peptide and Protein Science
    Institute for Molecular Bioscience
    of Institute for Molecular Bioscien
    Institute for Molecular Bioscience

  • Professor David Hume

    Professor
    Mater Research Institute-UQ
    Faculty of Medicine

  • Professor Brandon Wainwright

    Professor
    Frazer Institute
    Faculty of Medicine
    Affiliate Professor of Institute fo
    Institute for Molecular Bioscience
Funded by:
Cancer Council Queensland